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WO2002070674A3 - A human member of the phospholipase d superfamily and methods for regulating its activity - Google Patents

A human member of the phospholipase d superfamily and methods for regulating its activity Download PDF

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Publication number
WO2002070674A3
WO2002070674A3 PCT/EP2002/001102 EP0201102W WO02070674A3 WO 2002070674 A3 WO2002070674 A3 WO 2002070674A3 EP 0201102 W EP0201102 W EP 0201102W WO 02070674 A3 WO02070674 A3 WO 02070674A3
Authority
WO
WIPO (PCT)
Prior art keywords
phospholipase
superfamily
regulating
activity
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/001102
Other languages
French (fr)
Other versions
WO2002070674A2 (en
Inventor
Rainer H Koehler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002247679A priority Critical patent/AU2002247679A1/en
Publication of WO2002070674A2 publication Critical patent/WO2002070674A2/en
Publication of WO2002070674A3 publication Critical patent/WO2002070674A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents that regulate human lipase-like enzyme and reagents which bind to human lipase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, COPD, and CNS disorders.
PCT/EP2002/001102 2001-02-05 2002-02-04 A human member of the phospholipase d superfamily and methods for regulating its activity Ceased WO2002070674A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002247679A AU2002247679A1 (en) 2001-02-05 2002-02-04 A human member of the phospholipase d superfamily and methods for regulating its activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26589201P 2001-02-05 2001-02-05
US60/265,892 2001-02-05
US27649401P 2001-03-19 2001-03-19
US60/276,494 2001-03-19

Publications (2)

Publication Number Publication Date
WO2002070674A2 WO2002070674A2 (en) 2002-09-12
WO2002070674A3 true WO2002070674A3 (en) 2002-10-24

Family

ID=26951482

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001102 Ceased WO2002070674A2 (en) 2001-02-05 2002-02-04 A human member of the phospholipase d superfamily and methods for regulating its activity

Country Status (2)

Country Link
AU (1) AU2002247679A1 (en)
WO (1) WO2002070674A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024905A2 (en) * 1996-12-06 1998-06-11 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024905A2 (en) * 1996-12-06 1998-06-11 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAO JINGXIN ET AL: "A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.", VIRUS RESEARCH, vol. 48, no. 1, U60644, 1997, pages 11 - 18, XP002209546, ISSN: 0168-1702, Retrieved from the Internet <URL:EMBL> *
DATABASE EMBL [online] 9 March 2001 (2001-03-09), STRAUBERG R: "Homo sapiens, similar to vaccinia virus HindIII K4L ORF, clone MGC:870", XP002209296, retrieved from EMBL Database accession no. BC000553 *
DATABASE EMBL 13 November 1998 (1998-11-13), PEDERSEN K M: "Mus musculus schwannoma-associated protein (SAM9) mRNA, complete cds", XP002209548, retrieved from EMBL Database accession no. AF026124 *
DATABASE EMBL 4 October 1996 (1996-10-04), UPTON C ET AL: "Human HU-K4, complete cds", XP002209547, retrieved from EMBL Database accession no. U60644 *
PEDERSEN K M ET AL: "EXPRESSION OF A NOVEL MURINE PHOSPHOLIPASE D HOMOLOG COINCIDES WITHLATE NEURONAL DEVELOPMENT IN THE FOREBRAIN-", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 47, AF026124, 20 November 1998 (1998-11-20), pages 31494 - 31504, XP002926191, ISSN: 0021-9258, Retrieved from the Internet <URL:EMBL> *
PONTING C P ET AL: "A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues.", PROTEIN SCIENCE, vol. 5, no. 5, 1996, pages 914 - 922, XP001098616, ISSN: 0961-8368 *

Also Published As

Publication number Publication date
WO2002070674A2 (en) 2002-09-12
AU2002247679A1 (en) 2002-09-19

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