[go: up one dir, main page]

WO2002066012A3 - Liposomes amphoteres et leur utilisation - Google Patents

Liposomes amphoteres et leur utilisation Download PDF

Info

Publication number
WO2002066012A3
WO2002066012A3 PCT/EP2002/001880 EP0201880W WO02066012A3 WO 2002066012 A3 WO2002066012 A3 WO 2002066012A3 EP 0201880 W EP0201880 W EP 0201880W WO 02066012 A3 WO02066012 A3 WO 02066012A3
Authority
WO
WIPO (PCT)
Prior art keywords
amphoteric liposomes
liposomes
membrane
amphoteric
permanent
Prior art date
Application number
PCT/EP2002/001880
Other languages
German (de)
English (en)
Other versions
WO2002066012A2 (fr
Inventor
Steffen Panzner
Stefan Fankhaenel
Frank Essler
Cornelia Panzner
Original Assignee
Novosom Ag
Steffen Panzner
Stefan Fankhaenel
Frank Essler
Cornelia Panzner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novosom Ag, Steffen Panzner, Stefan Fankhaenel, Frank Essler, Cornelia Panzner filed Critical Novosom Ag
Priority to AU2002234643A priority Critical patent/AU2002234643B2/en
Priority to CA2438116A priority patent/CA2438116C/fr
Priority to DE50210271T priority patent/DE50210271D1/de
Priority to EP02701290A priority patent/EP1363601B1/fr
Priority to BRPI0207775A priority patent/BRPI0207775B1/pt
Priority to JP2002565572A priority patent/JP2004525898A/ja
Publication of WO2002066012A2 publication Critical patent/WO2002066012A2/fr
Publication of WO2002066012A3 publication Critical patent/WO2002066012A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des liposomes amphotères contenant des porteurs de charges positifs et négatifs membraneux ou formant une membrane. L'invention concerne également leur utilisation.
PCT/EP2002/001880 2001-02-21 2002-02-21 Liposomes amphoteres et leur utilisation WO2002066012A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2002234643A AU2002234643B2 (en) 2001-02-21 2002-02-21 Amphoteric liposomes and the use thereof
CA2438116A CA2438116C (fr) 2001-02-21 2002-02-21 Liposomes amphoteres et leur utilisation
DE50210271T DE50210271D1 (de) 2001-02-21 2002-02-21 Amphotere liposomen und verwendung dieser
EP02701290A EP1363601B1 (fr) 2001-02-21 2002-02-21 Liposomes amphoteres et leur utilisation
BRPI0207775A BRPI0207775B1 (pt) 2001-02-21 2002-02-21 lipossomos anfotéricos, método para carregamento dos mesmos com ingredientes ativos e sua utilização
JP2002565572A JP2004525898A (ja) 2001-02-21 2002-02-21 両性リポソーム及びその使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10109897.9 2001-02-21
DE10109897A DE10109897A1 (de) 2001-02-21 2001-02-21 Fakultativ kationische Liposomen und Verwendung dieser

Publications (2)

Publication Number Publication Date
WO2002066012A2 WO2002066012A2 (fr) 2002-08-29
WO2002066012A3 true WO2002066012A3 (fr) 2002-12-19

Family

ID=7675950

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001880 WO2002066012A2 (fr) 2001-02-21 2002-02-21 Liposomes amphoteres et leur utilisation

Country Status (11)

Country Link
US (4) US7371404B2 (fr)
EP (1) EP1363601B1 (fr)
JP (5) JP2004525898A (fr)
CN (1) CN1241549C (fr)
AT (1) ATE363893T1 (fr)
AU (1) AU2002234643B2 (fr)
BR (1) BRPI0207775B1 (fr)
CA (1) CA2438116C (fr)
DE (2) DE10109897A1 (fr)
ES (1) ES2289079T3 (fr)
WO (1) WO2002066012A2 (fr)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10109897A1 (de) * 2001-02-21 2002-11-07 Novosom Ag Fakultativ kationische Liposomen und Verwendung dieser
DE10207177A1 (de) * 2002-02-19 2003-09-04 Novosom Ag Fakultativ kationische Lipide
US7858117B2 (en) * 2002-02-21 2010-12-28 Novosom Ag Amphoteric liposomes and their use
CA2487274A1 (fr) * 2002-05-06 2003-11-13 Nucleonics Inc. Procede et dispositif pour parcourir une liste de balayage dans un systeme de communication
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
DE10255106A1 (de) * 2002-11-24 2004-06-09 Novosom Ag Liposomale Glucocorticoide
EP1547580A1 (fr) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Chargement des nanoparticules colloidales avec un principe actif de camptothécine
DE102004054730A1 (de) * 2004-03-28 2006-05-11 Novosom Ag Serumstabile amphotere Liposomen
US8815599B2 (en) 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
US20060216343A1 (en) * 2004-11-05 2006-09-28 Steffen Panzner Pharmaceutical compositions comprising an oligonucleotide as an active agent
EP1764090A1 (fr) * 2005-09-15 2007-03-21 Novosom AG Liposomes amphotères pour l'application locale de médicaments
WO2006053646A2 (fr) * 2004-11-19 2006-05-26 Novosom Ag Ameliorations apportees ou se rapportant a des compositions pharmaceutiques destinees a une administration locale
EP1676569A1 (fr) * 2004-12-30 2006-07-05 Pevion Biotech Ltd. Lyophilisation de virosomes
EP1764089A1 (fr) * 2005-09-15 2007-03-21 Novosom AG Liposomes stables dans le sérum comprenant des mélanges lipidiques amphotériques II
WO2007031333A2 (fr) * 2005-09-15 2007-03-22 Novosom Ag Ameliorations apportees a des liposomes amphoteres
US20080088046A1 (en) * 2006-10-13 2008-04-17 Steffen Panzner Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
US20120021042A1 (en) * 2005-09-15 2012-01-26 Steffen Panzner Efficient Method For Loading Amphoteric Liposomes With Nucleic Acid Active Substances
EP1911443A1 (fr) * 2006-10-13 2008-04-16 Novosom AG Liposomes amphotériques, méthode de formulation de liposomes amphotériques et méthode de charge de liposomes amphotériques
EP1934348B1 (fr) * 2005-10-11 2018-05-02 Ben-Gurion University Of The Negev Research And Development Authority Compositions permettant d'effectuer un silençage de l'expression de vdac1 et des utilisations de celles-ci
JP5623016B2 (ja) 2005-12-01 2014-11-12 プロネイ・セラピューティクス・インコーポレイテッドＰｒｏｎａｉｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 癌治療法およびそれに用いる医薬組成物
CA2631677C (fr) * 2005-12-01 2014-08-12 Pronai Therapeutics, Inc. Formulation de liposomes amphoteres
EP1962805B1 (fr) 2005-12-08 2016-07-06 Insmed Incorporated Compositions à base de lipide d'anti-infectieux pour traiter des infections pulmonaires
JP5600432B2 (ja) * 2006-04-06 2014-10-01 インスメッド， インコーポレイテッド コアセルベート化誘導リポソーム被包法及びその調合物
US20080089932A1 (en) * 2006-10-13 2008-04-17 Steffen Panzner Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
US20140178462A1 (en) * 2006-10-13 2014-06-26 Marina Biotech, Inc. Amphoteric liposomes comprising neutral lipids
US8193246B2 (en) * 2006-12-19 2012-06-05 Marina Biotech, Inc. Lipids and lipid assemblies comprising transfection enhancer elements
SI2308514T1 (sl) 2007-03-23 2013-09-30 To-Bbb Holding B.V. Konjugati za prenos zdravila preko krvno-moĹľganske pregrade
US20080260895A1 (en) * 2007-04-17 2008-10-23 Vermeire Drew A Milk replacer composition and product and method for producing the same
DK2494993T3 (en) * 2007-05-04 2018-11-12 Marina Biotech Inc Amino acid lipids and uses thereof
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
DE102007029471A1 (de) 2007-06-20 2008-12-24 Novosom Ag Neue fakultativ kationische Sterole
EP2170932A4 (fr) 2007-06-20 2012-10-10 Phylogica Ltd Compositions et leurs utilisations dans le traitement du syndrome de détresse respiratoire aigu (ards) et de troubles cliniques associés à celui-ci
WO2009031896A2 (fr) * 2007-09-07 2009-03-12 Synvolux Ip B.V. Liposomes améliorés et leurs utilisations
EP2211840B1 (fr) * 2007-10-12 2019-12-04 Novosom Verwaltungs GmbH Liposomes amphotères comprenant des lipides neutres
CN102112110A (zh) * 2008-06-06 2011-06-29 米尔纳医疗股份有限公司 用于RNAi试剂体内递送的新型组合物
CN104382853A (zh) 2008-10-16 2015-03-04 玛瑞纳生物技术有限公司 基因沉默治疗剂的脂质体有效递送方法和组合物
JP5392707B2 (ja) * 2009-03-31 2014-01-22 株式会社Ｎｔｔドコモ 膜小胞分裂システム
WO2010113172A1 (fr) * 2009-03-31 2010-10-07 Council Of Scientific & Industrial Research Compositions liposomales amphotères pour l'administration cellulaire de petites molécules d'arn destinées à être utilisées dans l'arn interférence
WO2010135714A2 (fr) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Méthodes de modulation de l'expression des adipocytes utilisant des compositions de micro-arn
EP2823810B9 (fr) 2009-07-09 2019-10-30 Novosom Verwaltungs GmbH Émulation de structures de lipoprotéine
EP2277508B1 (fr) * 2009-07-09 2012-04-25 Marina Biotech, Inc. Émulation de structures de lipoprotéine
HUE038039T2 (hu) * 2009-12-01 2018-09-28 Translate Bio Inc mRNS bejuttatása fehérjék és enzimek kiegészítésére humán genetikai betegségekben
WO2011120023A1 (fr) 2010-03-26 2011-09-29 Marina Biotech, Inc. Composés d'acide nucléique pour inhiber l'expression de gène de survivine et utilisations de ceux-ci
WO2011133584A2 (fr) 2010-04-19 2011-10-27 Marina Biotech, Inc. Composés de type acide nucléique pour inhiber l'expression du gène hras et leurs utilisations
WO2011139842A2 (fr) 2010-04-28 2011-11-10 Marina Biotech, Inc. Composés d'acide nucléique destinés à inhiber l'expression du gène fgfr3 et utilisations associées
CA2807552A1 (fr) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Acides nucleiques modifies et leurs procedes d'utilisation
PL4108671T3 (pl) 2010-10-01 2025-02-24 Modernatx, Inc. Zmodyfikowane nukleozydy, nukleotydy i kwasy nukleinowe oraz ich zastosowania
WO2012075040A2 (fr) 2010-11-30 2012-06-07 Shire Human Genetic Therapies, Inc. Arnm pour l'utilisation dans le traitement de maladies génétiques humaines
WO2012109495A1 (fr) 2011-02-09 2012-08-16 Metabolic Solutions Development Company, Llc Cibles cellulaires de thiazolidinediones
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US9880151B2 (en) 2011-05-23 2018-01-30 Phylogica Limited Method of determining, identifying or isolating cell-penetrating peptides
PL2717893T3 (pl) 2011-06-08 2019-12-31 Translate Bio, Inc. Kompozycje nanocząstek lipidowych i sposoby do dostarczania mRNA
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
KR102014061B1 (ko) 2011-10-03 2019-08-28 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도
CA3018046A1 (fr) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Nucleoside, nucleotide, et compositions d'acide nucleique modifies
CN102532259A (zh) * 2012-03-09 2012-07-04 中国药科大学 基于寡肽的阳离子脂质衍生物及在药剂制剂中的应用
CN102603866B (zh) * 2012-03-15 2014-01-15 中国药科大学 基于寡肽的pH敏感型两性离子及其在药剂中的应用
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
HK1206636A1 (zh) 2012-04-02 2016-01-15 Modernatx, Inc. 用於制备肿瘤相关蛋白和多肽的修饰的多核苷酸
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
MX369828B (es) 2012-05-21 2019-11-22 Insmed Inc Sistemas para tratar infecciones pulmonares.
WO2013185067A1 (fr) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Polynucléotides résistant à la nucléase et leurs utilisations
US9763881B2 (en) * 2012-06-11 2017-09-19 Council Of Scientific And Industrial Research Rice bran-lipids based formulation and process for preparation thereof for selective delivery of genes to cancer cells
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
WO2014068408A2 (fr) 2012-10-23 2014-05-08 Caris Life Sciences Switzerland Holdings, S.A.R.L. Aptamères et leurs utilisations
BR112015010220A2 (pt) 2012-11-05 2017-12-05 Pronai Therapeutics Inc métodos de utilização de biomarcadores para tratamento de câncer
SMT202200337T1 (it) 2012-11-26 2022-09-14 Modernatx Inc Rna modificato al livello del terminale
EP3581186A1 (fr) 2012-11-29 2019-12-18 Insmed Incorporated Formulations de vancomycine stabilisées
CA2895847C (fr) 2012-12-19 2019-01-08 Caris Science, Inc. Compositions et procedes pour le criblage d'aptameres
AU2014236396A1 (en) 2013-03-14 2015-08-13 Shire Human Genetic Therapies, Inc. Methods for purification of messenger RNA
IL290953B2 (en) 2013-03-14 2024-01-01 Ethris Gmbh CFTR mRNA Assemblies and Related Methods and Uses
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CA2903882A1 (fr) 2013-03-15 2014-09-18 Mirna Therapeutics, Inc. Traitements combines du cancer a l'aide de micro-arn et d'inhibiteurs d'egfr-tki
EP3013975A1 (fr) 2013-06-24 2016-05-04 Mirna Therapeutics, Inc. Biomarqueurs de l'activité de mir-34
JP5914418B2 (ja) 2013-06-26 2016-05-11 富士フイルム株式会社 脂質粒子、核酸送達キャリア、核酸送達キャリア製造用組成物、脂質粒子の製造方法及び遺伝子導入方法
EP3052106A4 (fr) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucléotides codant des polypeptides de modulation immunitaire
BR112016007255A2 (pt) 2013-10-03 2017-09-12 Moderna Therapeutics Inc polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
CN106413811A (zh) 2013-10-22 2017-02-15 夏尔人类遗传性治疗公司 精氨基琥珀酸合成酶缺乏症的mrna疗法
EA201992208A1 (ru) 2013-10-22 2020-07-31 Транслейт Био, Инк. ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
US20160136181A1 (en) 2014-04-01 2016-05-19 Mirna Therapeutics, Inc Microrna dosing regimens
LT3981437T (lt) 2014-04-23 2025-01-10 Modernatx, Inc. Nuleorūgšties vakcinos
SG11201608725YA (en) 2014-04-25 2016-11-29 Shire Human Genetic Therapies Methods for purification of messenger rna
ME03536B (fr) 2014-05-15 2020-04-20 Insmed Inc Méthodes de traitement d'infections pulmonaires mycobactériennes non-tuberculeuses
JP6240570B2 (ja) 2014-07-17 2017-11-29 富士フイルム株式会社 脂質粒子および核酸送達キャリア
US10722599B2 (en) 2015-02-04 2020-07-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipid assemblies and uses thereof and some pH and electrostatic modulating lipids to be used in said assemblies
WO2017031232A1 (fr) 2015-08-17 2017-02-23 Modernatx, Inc. Procédés de préparation de particules et compositions associées
LT3350157T (lt) 2015-09-17 2022-02-25 Modernatx, Inc. Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu
CA3007955A1 (fr) 2015-12-10 2017-06-15 Modernatx, Inc. Nanoparticules de lipide pour l'administration d'agents therapeutiques
HRP20220268T1 (hr) 2015-12-22 2022-05-13 Modernatx, Inc. Spojevi i pripravci za unutarstaničnu isporuku sredstava
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
WO2018157154A2 (fr) 2017-02-27 2018-08-30 Translate Bio, Inc. Nouvel arnm cftr à codons optimisés
CA3055653A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Formulation de nanoparticules lipidiques
JP7167049B2 (ja) 2017-03-15 2022-11-08 モデルナティエックス インコーポレイテッド 治療剤の細胞内送達のための化合物及び組成物
WO2018170322A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Formes cristallines d'aminolipides
US11173190B2 (en) 2017-05-16 2021-11-16 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR
EP3638678A1 (fr) 2017-06-14 2020-04-22 Modernatx, Inc. Composés et compositions pour l'administration intracellulaire d'agents
US11786607B2 (en) 2017-06-15 2023-10-17 Modernatx, Inc. RNA formulations
US11744801B2 (en) 2017-08-31 2023-09-05 Modernatx, Inc. Methods of making lipid nanoparticles
KR20200050982A (ko) * 2017-09-04 2020-05-12 이치마루 화루코스 가부시키가이샤 pH 감수성 리포솜 및 그 제조 방법
WO2019048645A1 (fr) 2017-09-08 2019-03-14 Mina Therapeutics Limited Compositions stabilisées de petits arn activateurs (parna) de cebpa et procédés d'utilisation
BR112020007470A2 (pt) 2017-10-20 2020-10-27 Biontech Rna Pharmaceuticals Gmbh métodos para produzir um colóide de lipossoma, para preparar partículas, para a fabricação de fluxo contínuo, para preparar uma composição congelada e para preparar uma composição aquosa, colóide de lipossoma, composições, composição congelada e composição aquosa
TW201936201A (zh) 2017-12-14 2019-09-16 美商堅固生物科技公司 基因之非病毒生產及遞送
EP3773505A4 (fr) 2018-03-30 2021-12-22 Insmed Incorporated Procédés pour la fabrication continue de produits médicamenteux liposomaux
EP3775211B1 (fr) 2018-04-12 2023-04-05 MiNA Therapeutics Limited Compositions
US20190381034A1 (en) * 2018-06-14 2019-12-19 Ming Fang Pharmaceutical composition and method for acute on chronic liver failure and related liver diseases
EP3841208A1 (fr) 2018-08-24 2021-06-30 Translate Bio, Inc. Procédés de purification d'arn messager
WO2020047229A1 (fr) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition de protéines kinases pour traiter la maladie de friedreich
CA3113436A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Composes et compositions pour l'administration intracellulaire d'agents therapeutiques
AU2019345067A1 (en) 2018-09-19 2021-04-08 Modernatx, Inc. High-purity peg lipids and uses thereof
CA3113025A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg et leurs utilisations
EP3852728B1 (fr) 2018-09-20 2024-09-18 ModernaTX, Inc. Préparation de nanoparticules lipidiques et leurs méthodes d'administration
WO2020106946A1 (fr) 2018-11-21 2020-05-28 Translate Bio, Inc. Traitement de la fibrose kystique par administration d'arnm nébulisé codant pour la cftr
US20220211740A1 (en) 2019-04-12 2022-07-07 Mina Therapeutics Limited Sirt1-sarna compositions and methods of use
WO2021055833A1 (fr) 2019-09-19 2021-03-25 Modernatx, Inc. Composés lipidiques de queue ramifiés et compositions pour l'administration intracellulaire d'agents thérapeutiques
IL297193A (en) 2020-04-09 2022-12-01 Verve Therapeutics Inc Basic editing of pcks9 and methods of using it to treat diseases
WO2021255262A1 (fr) 2020-06-19 2021-12-23 Sylentis Sau Arnsi et compositions pour le traitement prophylactique et thérapeutique des maladies virales
EP4213882A4 (fr) 2020-09-15 2025-02-26 Verve Therapeutics, Inc. Nucléases effectrices tal pour l'édition de gènes
GB2603454A (en) 2020-12-09 2022-08-10 Ucl Business Ltd Novel therapeutics for the treatment of neurodegenerative disorders
EP4015634A1 (fr) 2020-12-15 2022-06-22 Sylentis, S.A.U. Arnsi et compositions pour le traitement prophylactique et thérapeutique des maladies virales
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
JP2024511092A (ja) 2021-03-26 2024-03-12 ミナ セラピューティクス リミテッド ＴＭＥＭ１７３ｓａＲＮＡ組成物及び使用方法
WO2023099884A1 (fr) 2021-12-01 2023-06-08 Mina Therapeutics Limited Compositions d'arnsa de pax6 et procédés d'utilisation
GB202117758D0 (en) 2021-12-09 2022-01-26 Ucl Business Ltd Therapeutics for the treatment of neurodegenerative disorders
WO2023170435A1 (fr) 2022-03-07 2023-09-14 Mina Therapeutics Limited Compositions de petits arn activateurs d'il10 et procédés d'utilisation
WO2024125597A1 (fr) 2022-12-14 2024-06-20 Providence Therapeutics Holdings Inc. Compositions et procédés pour des maladies infectieuses
WO2024134199A1 (fr) 2022-12-22 2024-06-27 Mina Therapeutics Limited Compositions d'arnsa chimiquement modifiées et procédés d'utilisation
IL321425A (en) 2022-12-23 2025-08-01 Biontech Delivery Tech Gmbh compound
WO2025046121A1 (fr) 2023-09-01 2025-03-06 Novoarc Gmbh Nanoparticule lipidique avec charge d'acide nucléique et lipide ionisable
WO2025136963A1 (fr) * 2023-12-22 2025-06-26 Coty Inc. Micro-vésicules cationiques et vecteurs fonctionnalisés de type exosome pour administration d'agent fonctionnel sur la peau

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039019A1 (fr) * 1996-04-12 1997-10-23 University Of Pittsburgh Nouveaux derives de cholesteryle cationiques contenant des groupes polaires cycliques
WO2000028972A2 (fr) * 1998-11-17 2000-05-25 Novosom Gmbh Nanocapsules et leur procede de production
WO2000059474A1 (fr) * 1999-04-06 2000-10-12 Isis Pharmaceuticals, Inc. Lipides et vesicules fusiogenes

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4891208A (en) * 1985-04-10 1990-01-02 The Liposome Company, Inc. Steroidal liposomes
US5283122A (en) * 1984-04-19 1994-02-01 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
DE3572491D1 (en) 1984-07-25 1989-09-28 Ciba Geigy Ag Phosphatidyl compounds, process for their preparation and their use
US5077211A (en) * 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
US5290563A (en) * 1989-07-27 1994-03-01 Laboratoire Des Stallergenes Method for combining a mixture of heterogeneous substances with liposomes
US5165994A (en) * 1990-06-05 1992-11-24 University Of Delaware Spontaneous equilbrium surfactant vesicles
US5302389A (en) * 1992-08-17 1994-04-12 Board Of Regents, The University Of Texas System Method for treating UV-induced suppression of contact hypersensitivity by administration of T4 endonuclease
JP2950520B2 (ja) * 1993-04-02 1999-09-20 アンティキャンサー インコーポレーテド 毛胞に有益な配合物を送達する方法
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US5981501A (en) 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
US6258792B1 (en) * 1996-04-12 2001-07-10 University Of Pittsburgh Cationic cholesteryl derivatives containing cyclic polar groups
KR100507660B1 (ko) * 1996-09-13 2005-08-10 리폭센 테크놀로지즈 리미티드 리포좀
US7384923B2 (en) * 1999-05-14 2008-06-10 Lipoxen Technologies Limited Liposomes
US5962015A (en) * 1997-05-02 1999-10-05 Kobo Products S.A.R.L. Stabilized liposomes
EP1027033B1 (fr) * 1997-05-14 2009-07-22 The University Of British Columbia Encapsulation hautement éfficace d'acides nucléiques dans des vésicules lipidiques
US20030035829A1 (en) * 1997-07-24 2003-02-20 Townsend And Townsend And Crew Liposomal compositions for the delivery of nucleic acid catalysts
FR2766706B1 (fr) * 1997-07-30 2001-05-25 Biovector Therapeutics Sa Complexes particulaires stables de charge globale neutre ou negative de structure multilamellaire composes par au moins une substance biologiquement active globalement anionique et un constituant cationique, leur preparation et utilisation
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
JPH11302199A (ja) * 1998-04-16 1999-11-02 Sankyo Co Ltd 薬物運搬体を構成するグラフト共重合体
JP2000198731A (ja) * 1998-10-29 2000-07-18 Sankyo Co Ltd 毒性の低減されたリポソ―ム
DE10010264A1 (de) 2000-03-02 2001-09-13 Novosom Gmbh Stabilisierte Liposomen und Hüllstrukturen
DE10109897A1 (de) * 2001-02-21 2002-11-07 Novosom Ag Fakultativ kationische Liposomen und Verwendung dieser
US7858117B2 (en) 2002-02-21 2010-12-28 Novosom Ag Amphoteric liposomes and their use
WO2007031333A2 (fr) * 2005-09-15 2007-03-22 Novosom Ag Ameliorations apportees a des liposomes amphoteres

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039019A1 (fr) * 1996-04-12 1997-10-23 University Of Pittsburgh Nouveaux derives de cholesteryle cationiques contenant des groupes polaires cycliques
WO2000028972A2 (fr) * 1998-11-17 2000-05-25 Novosom Gmbh Nanocapsules et leur procede de production
WO2000059474A1 (fr) * 1999-04-06 2000-10-12 Isis Pharmaceuticals, Inc. Lipides et vesicules fusiogenes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOPHYSICAL JOURNAL (2000), 79(3), 1438-1446, 2000 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HAFEZ, ISMAIL M. ET AL: "Tunable pH- sensitive liposomes composed of mixtures of cationic and anionic lipids", XP002204268, retrieved from STN Database accession no. 133:355087 CA *
HITOYUKI FUKUDA ET AL: "BILAYER-FORMING ION-PAIR AMPHIPHILES FROM SINGLE-CHAIN SURFACTANTS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 112, no. 4, 14 February 1990 (1990-02-14), pages 1635 - 1637, XP000100893, ISSN: 0002-7863 *
R. LEVENTIS ET AL.: "pH-dependent stability and fusion of liposomes combining protonatable double-chain amphiphiles with phosphatidylethanolamine", BIOCHEMISTRY, vol. 26, no. 12, 1987, Easton (US), pages 3267 - 3276, XP002025621 *
ZI CHEN LI ET AL: "SYNTHESIS OF CHOLESTEROL DERIVATIVES WITH AMINO ACID AS HYDROPHILIC GROUP AND THE VESICLES PREPARED THEREFROM", CHINESE CHEMICAL LETTERS, XX, XX, vol. 12, no. 10, 1999, pages 1007 - 1010, XP008005314, ISSN: 1001-8417 *

Also Published As

Publication number Publication date
JP2004525898A (ja) 2004-08-26
ATE363893T1 (de) 2007-06-15
ES2289079T3 (es) 2008-02-01
JP2014218520A (ja) 2014-11-20
US20030099697A1 (en) 2003-05-29
BRPI0207775B1 (pt) 2015-10-20
JP2014031383A (ja) 2014-02-20
US20070269504A1 (en) 2007-11-22
CA2438116C (fr) 2011-10-11
JP2011021026A (ja) 2011-02-03
EP1363601B1 (fr) 2007-06-06
JP2016104786A (ja) 2016-06-09
US7780983B2 (en) 2010-08-24
DE50210271D1 (de) 2007-07-19
US20070252295A1 (en) 2007-11-01
EP1363601A2 (fr) 2003-11-26
AU2002234643B2 (en) 2007-06-21
CA2438116A1 (fr) 2002-08-29
US20110293695A1 (en) 2011-12-01
CN1492756A (zh) 2004-04-28
BR0207775A (pt) 2004-03-30
WO2002066012A2 (fr) 2002-08-29
JP5480764B2 (ja) 2014-04-23
US7371404B2 (en) 2008-05-13
DE10109897A1 (de) 2002-11-07
CN1241549C (zh) 2006-02-15

Similar Documents

Publication Publication Date Title
WO2002066012A3 (fr) Liposomes amphoteres et leur utilisation
AU2002234643A1 (en) Amphoteric liposomes and the use thereof
AU2002315389A1 (en) Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
WO2002097130A3 (fr) Microstructures et leur utilisation pour l'evolution orientee de biomolecules
AU2001282449A1 (en) Applications of the biofeedback technique
IL162266A (en) Substituted 2-thio-3,5-dicyano-4- phenyl-6-aminopyridines and the use of the same
CA98892S (en) Lobby dust pan
AU144678S (en) Bottle
AU2002359512A1 (en) Belts and methods of use thereof
AU2002315388A1 (en) Novel phenylamino-pyrimidines and uses thereof
AU2003275159A1 (en) Electrically-coupled micro-electro-mechanical filter systems and methods
ZA200303760B (en) Use of polymers as filtering aids and/or stabilizers.
AU2001295620A1 (en) Use of polymers as filtering aids and/or stabilizers
AU2001269704A1 (en) Oxazinoquinolones useful for the treatment of viral infections
AU2003245134A1 (en) Oxytocin as cardiomyogenesis inducer and uses thereof
PL370031A1 (en) Novel amylases and uses thereof
AU2001233588A1 (en) New toralactone and its derivation and the use of decreasing blood-fat and losing weight
AU2002330245A1 (en) Isolated polypeptides and compositions from the venom of p. transvaalicus and methods of use
AU2001272721A1 (en) The filtration of car exhaustes gases
AU2002366793A1 (en) Improved lilly of the valley aromachemicals
AU2002241162A1 (en) Intimins in the prevention or treatment of infections:ii
AU2001275487A1 (en) Regulation of the p21 gene and uses thereof
KR100522448B1 (ko) Hiv 유사입자 및 그 용도
AU2003255866A8 (en) Gp41 epitope and uses thereof for the treatment of hiv infections
AU2002251271A1 (en) Stimulation of the immune system

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 028052137

Country of ref document: CN

Ref document number: 2002565572

Country of ref document: JP

Ref document number: 2438116

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002234643

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2002701290

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002701290

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2002701290

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 2002234643

Country of ref document: AU