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WO2002060948A1 - Novel g protein-coupled receptor protein and dna thereof - Google Patents

Novel g protein-coupled receptor protein and dna thereof Download PDF

Info

Publication number
WO2002060948A1
WO2002060948A1 PCT/JP2002/000707 JP0200707W WO02060948A1 WO 2002060948 A1 WO2002060948 A1 WO 2002060948A1 JP 0200707 W JP0200707 W JP 0200707W WO 02060948 A1 WO02060948 A1 WO 02060948A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
ligand
screening
novel
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/000707
Other languages
French (fr)
Japanese (ja)
Inventor
Takeo Moriya
Takashi Ito
Yasushi Shintani
Nobuyuki Miyajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of WO2002060948A1 publication Critical patent/WO2002060948A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

It is intended to provide a novel protein useful in screening an agonist/an antagonist. A human-origin protein or its salt; a DNA encoding this protein; a method of determining a ligand to the protein; a screening method/a screening kit for a compound capable of altering the binding properties of the ligand to the protein; compounds obtained by the screening method or salts thereof, etc. The above-described human-origin protein or the DNA encoding the same are usable in: (1) determining a ligand to the protein; (2) preventives and/or remedies for diseases in association with the hypofunction of the above protein; (3) screening a compound (an agonist, an antagonist or the like) capable of altering the binding properties of the protein of the invention to the ligand; etc.
PCT/JP2002/000707 2001-01-31 2002-01-30 Novel g protein-coupled receptor protein and dna thereof Ceased WO2002060948A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001024193 2001-01-31
JP2001-24193 2001-01-31
JP2001065292 2001-03-08
JP2001-65292 2001-03-08

Publications (1)

Publication Number Publication Date
WO2002060948A1 true WO2002060948A1 (en) 2002-08-08

Family

ID=26608674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/000707 Ceased WO2002060948A1 (en) 2001-01-31 2002-01-30 Novel g protein-coupled receptor protein and dna thereof

Country Status (1)

Country Link
WO (1) WO2002060948A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077330A2 (en) * 2000-04-06 2001-10-18 Pharmacia & Upjohn Company G protein-coupled receptors
DE10019120A1 (en) * 2000-04-18 2001-10-25 Michael Brues New human platelet-activating factor (PAF) receptor-2 gene, useful for diagnosis and treatment of PAF-related diseases
WO2001098351A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. G-protein coupled receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077330A2 (en) * 2000-04-06 2001-10-18 Pharmacia & Upjohn Company G protein-coupled receptors
DE10019120A1 (en) * 2000-04-18 2001-10-25 Michael Brues New human platelet-activating factor (PAF) receptor-2 gene, useful for diagnosis and treatment of PAF-related diseases
WO2001098351A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. G-protein coupled receptors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUNZ, D. ET AL.: "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression and construction of a novel epitope-bearing analog", J. BIOL. CHEM., vol. 267, no. 13, 1992, pages 9101 - 9106, XP002951003 *

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