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WO2002059338A3 - Retroviral vectors for transduction into quiescent cells and packaging systems for them - Google Patents

Retroviral vectors for transduction into quiescent cells and packaging systems for them Download PDF

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Publication number
WO2002059338A3
WO2002059338A3 PCT/US2002/000378 US0200378W WO02059338A3 WO 2002059338 A3 WO2002059338 A3 WO 2002059338A3 US 0200378 W US0200378 W US 0200378W WO 02059338 A3 WO02059338 A3 WO 02059338A3
Authority
WO
WIPO (PCT)
Prior art keywords
quiescent cells
transduction
retroviral vectors
packaging systems
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/000378
Other languages
French (fr)
Other versions
WO2002059338A2 (en
Inventor
Candace Summerford
John T Gray
Jeng-Shin Lee
Richard C Mulligan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Harvard University
Original Assignee
Boston Childrens Hospital
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital, Harvard University filed Critical Boston Childrens Hospital
Priority to AU2002246958A priority Critical patent/AU2002246958B2/en
Priority to CA002433867A priority patent/CA2433867A1/en
Priority to EP02714708A priority patent/EP1358342A2/en
Publication of WO2002059338A2 publication Critical patent/WO2002059338A2/en
Anticipated expiration legal-status Critical
Publication of WO2002059338A3 publication Critical patent/WO2002059338A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13051—Methods of production or purification of viral material
    • C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Methods of producing retroviral vector particles capable of transducing therapeutic genes into quiescent cells and methods of gene transfer to quiescent cells comprising infection with a retroviral particle described herein.
PCT/US2002/000378 2001-01-06 2002-01-07 Retroviral vectors for transduction into quiescent cells and packaging systems for them Ceased WO2002059338A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002246958A AU2002246958B2 (en) 2001-01-06 2002-01-07 Vectors and packaging systems for transduction into quiescent cells
CA002433867A CA2433867A1 (en) 2001-01-06 2002-01-07 Retroviral vectors for transduction into quiescent cells and packaging systems for them
EP02714708A EP1358342A2 (en) 2001-01-06 2002-01-07 Retroviral vectors for transduction into quiescent cells and packaging systems for them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26019901P 2001-01-06 2001-01-06
US60/260,199 2001-01-06

Publications (2)

Publication Number Publication Date
WO2002059338A2 WO2002059338A2 (en) 2002-08-01
WO2002059338A3 true WO2002059338A3 (en) 2003-07-24

Family

ID=22988184

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000378 Ceased WO2002059338A2 (en) 2001-01-06 2002-01-07 Retroviral vectors for transduction into quiescent cells and packaging systems for them

Country Status (4)

Country Link
EP (1) EP1358342A2 (en)
AU (1) AU2002246958B2 (en)
CA (1) CA2433867A1 (en)
WO (1) WO2002059338A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124263A (en) * 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
WO2000046377A1 (en) * 1999-02-02 2000-08-10 Thomas Jefferson University Genetically engineered retroviral vector particles capable of infecting non-dividing cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124263A (en) * 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
WO2000046377A1 (en) * 1999-02-02 2000-08-10 Thomas Jefferson University Genetically engineered retroviral vector particles capable of infecting non-dividing cells

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1977, FRITSCH E F ET AL: "INHIBITION OF VIRAL DNA SYNTHESIS IN STATIONARY CHICKEN EMBRYO FIBROBLASTS INFECTED WITH AVIAN RETROVIRUSES", XP002237915, Database accession no. PREV197865024735 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1982, CHEN I S Y ET AL: "ESTABLISHMENT OF INFECTION BY SPLEEN NECROSIS VIRUS INHIBITION IN STATIONARY CELLS AND THE ROLE OF SECONDARY INFECTION", XP002237914, Database accession no. PREV198273069682 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1989, BAN J ET AL: "BOVINE LEUKEMIA VIRUS PACKAGING CELL LINE FOR RETROVIRUS-MEDIATED GENE TRANSFER", XP002237917, Database accession no. PREV198988107653 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1989, DOUGHERTY J P ET AL: "NEW RETROVIRUS HELPER CELLS WITH ALMOST NO NUCLEOTIDE SEQUENCE HOMOLOGY TO RETROVIRUS VECTORS", XP002237916, Database accession no. PREV198988049051 *
JIANG A ET AL: "A genetically engineered spleen necrosis virus-derived retroviral vector that displays the HIV type 1 glycoprotein 120 envelope peptide", HUMAN GENE THERAPY, XX, XX, vol. 10, no. 16, 1 November 1999 (1999-11-01), pages 2627 - 2636, XP002958279, ISSN: 1043-0342 *
JIANG AN ET AL: "Cell-type-specific gene transfer into human cells with retroviral vectors that display single-chain antibodies", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 72, no. 12, December 1998 (1998-12-01), pages 10148 - 10156, XP002190552, ISSN: 0022-538X *
JOURNAL OF GENERAL VIROLOGY, vol. 70, no. 8, 1989, pages 1987 - 1994, ISSN: 0022-1317 *
JOURNAL OF VIROLOGY, vol. 24, no. 2, 1977, EN, pages 461 - 469, ISSN: 0022-538X *
JOURNAL OF VIROLOGY, vol. 41, no. 1, 1982, pages 183 - 191, ISSN: 0022-538X *
JOURNAL OF VIROLOGY, vol. 63, no. 7, 1989, pages 3209 - 3212, ISSN: 0022-538X *
MIKAWA T ET AL: "IN VIVO ANALYSIS OF A NEW LACZ RETROVIRUS VECTOR SUITABLE FOR CELL LINEAGE MARKING IN AVIAN AND OTHER SPECIES", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 195, 1991, pages 516 - 523, XP002927996, ISSN: 0014-4827 *

Also Published As

Publication number Publication date
WO2002059338A2 (en) 2002-08-01
CA2433867A1 (en) 2002-08-01
EP1358342A2 (en) 2003-11-05
AU2002246958B2 (en) 2005-06-09

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