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WO2002059367A3 - Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis - Google Patents

Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis Download PDF

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Publication number
WO2002059367A3
WO2002059367A3 PCT/US2001/045096 US0145096W WO02059367A3 WO 2002059367 A3 WO2002059367 A3 WO 2002059367A3 US 0145096 W US0145096 W US 0145096W WO 02059367 A3 WO02059367 A3 WO 02059367A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
crohn
ulcerative colitis
patients
ibd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/045096
Other languages
French (fr)
Other versions
WO2002059367A2 (en
Inventor
Elizabeth E Mannick
Zhiyun Liu
Maria-Stella Serrano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Louisiana State University
Original Assignee
Louisiana State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Louisiana State University filed Critical Louisiana State University
Priority to US10/432,785 priority Critical patent/US20040077020A1/en
Publication of WO2002059367A2 publication Critical patent/WO2002059367A2/en
Anticipated expiration legal-status Critical
Publication of WO2002059367A3 publication Critical patent/WO2002059367A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Using RNA samples from mononuclear blood cells, gene sequences were identified that can be used to identify patients with IBD, and then distinguish patients with Crohn's disease from those with ulcerative colitis. Sequences were identified whose overexpression was distinct to patients with IBD, Crohn's disease, and ulcerative colitis when compared to patients with non-IBD intestinal disorders. Additionally, cluster analysis was used to identify twenty-five sequences that are IBD-related, and whose transcription pattern can be used in a microarray analysis to identify patients with IBD with a sensitivity of 84 % and a specificity of 100 %. Cluster analysis also identified thirty-six genes that could be used to distinguish patients with Crohn's disease from those with ulcerative colitis with a sensitivity of 89 % and a specificity of 80 %.
PCT/US2001/045096 2000-11-30 2001-11-30 Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis Ceased WO2002059367A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/432,785 US20040077020A1 (en) 2001-11-30 2001-11-30 Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25030300P 2000-11-30 2000-11-30
US60/250,303 2000-11-30
US26490901P 2001-01-19 2001-01-19
US60/264,909 2001-01-19
US28660201P 2001-04-26 2001-04-26
US60/286,602 2001-04-26

Publications (2)

Publication Number Publication Date
WO2002059367A2 WO2002059367A2 (en) 2002-08-01
WO2002059367A3 true WO2002059367A3 (en) 2003-09-18

Family

ID=27400303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045096 Ceased WO2002059367A2 (en) 2000-11-30 2001-11-30 Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis

Country Status (1)

Country Link
WO (1) WO2002059367A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7384736B2 (en) * 2001-09-06 2008-06-10 Decode Genetics Ehf. Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
US6893828B2 (en) 2001-09-06 2005-05-17 Decode Genetics Ehf. Methods for producing ex vivo models for inflammatory disease and uses thereof
WO2003027276A2 (en) * 2001-09-24 2003-04-03 University Of Aarhus Novel compositions and methods for diagnosis and treatment of lymphoma and leukemia
EP1462527A1 (en) * 2003-03-26 2004-09-29 CONARIS research institute AG Novel markers for inflammatory bowel disease
GB0412301D0 (en) 2004-06-02 2004-07-07 Diagenic As Product and method
WO2006010516A1 (en) * 2004-07-29 2006-02-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with methionine aminopeptidase 2 like protein (metap2-like)
US8080373B2 (en) * 2004-08-03 2011-12-20 Bauer Jr A Robert Method for the early detection of pancreatic cancer and other gastrointestinal disease conditions
US7820382B2 (en) 2004-08-03 2010-10-26 Bauer A Robert Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
EP1844158A4 (en) * 2004-12-06 2010-09-08 Univ Johns Hopkins BIOMARKERS FOR INFLAMMATORY INTESTINAL DISEASE
BRPI0611239A2 (en) * 2005-06-06 2016-11-16 Wyeth Corp methods of diagnosing a disease and distinguishing between a diagnosis of ulcerative colitis and a diagnosis of crohn's disease in a patient
JP5503942B2 (en) * 2009-10-30 2014-05-28 シスメックス株式会社 Determination method of disease onset
US8396872B2 (en) 2010-05-14 2013-03-12 National Research Council Of Canada Order-preserving clustering data analysis system and method
WO2016179469A1 (en) * 2015-05-07 2016-11-10 Abbvie Inc. Methods and compositions for diagnosing and treating inflammatory bowel disease
FI131584B1 (en) 2022-02-18 2025-07-18 Aabo Akademi Method for detecting and subtyping inflammatory intestinal diseases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] "acidic calponin", XP002226217, Database accession no. S80562 *
GRAHAM M F ET AL: "Phenotypic differentiation of human intestinal smooth muscle cells induced by chronic inflammation: Increased expression of smooth muscle-specific proteins in vitro.", MOLECULAR BIOLOGY OF THE CELL, vol. 7, no. SUPPL., 1996, Annual Meeting of the 6th International Congress on Cell Biology and the 36th American Society for Cell Biology;San Francisco, California, USA; December 7-11, 1996, pages 539A, XP008011952, ISSN: 1059-1524 *
HELLER R A ET AL: "Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 18 MAR 1997, vol. 94, no. 6, 18 March 1997 (1997-03-18), pages 2150 - 2155, XP002171597, ISSN: 0027-8424 *
SERRANO MARIA-STELLA ET AL: "Application of microarray analysis to Crohn's disease.", JPGN, vol. 31, no. Supplement 2, 2000, World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition;Boston, Massachusetts, USA; August 05-09, 2000, pages S83, XP008011953 *

Also Published As

Publication number Publication date
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