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WO2002057476A3 - Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa) - Google Patents

Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa) Download PDF

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Publication number
WO2002057476A3
WO2002057476A3 PCT/US2002/001887 US0201887W WO02057476A3 WO 2002057476 A3 WO2002057476 A3 WO 2002057476A3 US 0201887 W US0201887 W US 0201887W WO 02057476 A3 WO02057476 A3 WO 02057476A3
Authority
WO
WIPO (PCT)
Prior art keywords
hmbpa
microorganisms
butyrylamino
hydroxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/001887
Other languages
English (en)
Other versions
WO2002057476A2 (fr
WO2002057476A9 (fr
Inventor
Theron Hermann
Thomas A Patterson
Janice G Pero
Rogers Yocum R
Kai-Uwe Baldenius
Christine Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to KR20037009570A priority Critical patent/KR20040004495A/ko
Priority to US10/466,642 priority patent/US20040048343A1/en
Priority to CA002434518A priority patent/CA2434518A1/fr
Priority to JP2002558528A priority patent/JP2005503758A/ja
Priority to AU2002241944A priority patent/AU2002241944A1/en
Priority to EP02707543A priority patent/EP1377662A2/fr
Publication of WO2002057476A2 publication Critical patent/WO2002057476A2/fr
Publication of WO2002057476A9 publication Critical patent/WO2002057476A9/fr
Anticipated expiration legal-status Critical
Publication of WO2002057476A3 publication Critical patent/WO2002057476A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés de production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique ('HMBPA') et d'α-hydroxyisovalérate ('α-HIV') en utilisant des micro-organismes agissant comme des enzymes biosynthétiques modifiés de pantothénate. L'invention concerne également des micro-organismes de recombinaison et des états permettant leur culture. L'invention concerne enfin des compositions incluant le HMBPA ainsi que des compositions incluant le α-HIV.
PCT/US2002/001887 2001-01-19 2002-01-19 Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa) Ceased WO2002057476A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR20037009570A KR20040004495A (ko) 2001-01-19 2002-01-19 3-(2-히드록시-3-메틸-부티릴아미노)-프로피온산(ｈｍｂｐａ)의 제조 방법 및 이를 위한 미생물
US10/466,642 US20040048343A1 (en) 2002-01-19 2002-01-19 Method and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
CA002434518A CA2434518A1 (fr) 2001-01-19 2002-01-19 Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-methyl-butyrylamino)-propionique (hmbpa)
JP2002558528A JP2005503758A (ja) 2001-01-19 2002-01-19 ３−（２−ヒドロキシ−３−メチル−ブチリルアミノ）−プロピオン酸（ｈｍｂｐａ）の製造方法及び微生物
AU2002241944A AU2002241944A1 (en) 2001-01-19 2002-01-19 Methods and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
EP02707543A EP1377662A2 (fr) 2001-01-19 2002-01-19 Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-m thyl-butyrylamino)-propionique (hmbpa)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26305301P 2001-01-19 2001-01-19
US60/263,053 2001-01-19

Publications (3)

Publication Number Publication Date
WO2002057476A2 WO2002057476A2 (fr) 2002-07-25
WO2002057476A9 WO2002057476A9 (fr) 2003-04-10
WO2002057476A3 true WO2002057476A3 (fr) 2003-10-30

Family

ID=23000176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/001887 Ceased WO2002057476A2 (fr) 2001-01-19 2002-01-19 Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa)

Country Status (7)

Country Link
EP (1) EP1377662A2 (fr)
JP (1) JP2005503758A (fr)
KR (1) KR20040004495A (fr)
CN (1) CN1496400A (fr)
AU (1) AU2002241944A1 (fr)
CA (1) CA2434518A1 (fr)
WO (1) WO2002057476A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006504408A (ja) 2002-07-03 2006-02-09 ビーエーエスエフ アクチェンゲゼルシャフト パントテン酸の高生産のための微生物及び方法
DE112007001179T5 (de) 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
TW202122075A (zh) * 2019-12-11 2021-06-16 大江生醫股份有限公司 乳酸菌的代謝產物及其用於製備血管保健組合物之用途
CN112126666B (zh) * 2020-09-22 2022-04-08 廊坊梅花生物技术开发有限公司 核苷高产菌及其构建方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907567A1 (de) * 1999-02-22 2000-08-24 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von L-Valin
WO2002057474A2 (fr) * 2001-01-19 2002-07-25 Basf Aktiengesellschaft Production amelioree de pantothenate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907567A1 (de) * 1999-02-22 2000-08-24 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von L-Valin
WO2002057474A2 (fr) * 2001-01-19 2002-07-25 Basf Aktiengesellschaft Production amelioree de pantothenate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GORDON E M ET AL: "SYNTHESIS OF SUBSTRATED-BASED INHIBITORS OF HMG COA REDUCTASE (II)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 1, no. 3, 1991, pages 161 - 164, XP000940927, ISSN: 0960-894X *
SCHUMMER A ET AL: "POLYFUNCTIONAL (R)-2-HYDROXYCARBOXYLIC ACIDS BY REDUCTION OF 2-OXO ACIDS WITH HYDROGEN GAS OR FORMATE AND RESTING CELLS OF PROTEUS VULGARIS", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 47, no. 43, 1991, pages 9019 - 9034, XP000196414, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
EP1377662A2 (fr) 2004-01-07
JP2005503758A (ja) 2005-02-10
WO2002057476A2 (fr) 2002-07-25
CA2434518A1 (fr) 2002-07-25
CN1496400A (zh) 2004-05-12
KR20040004495A (ko) 2004-01-13
WO2002057476A9 (fr) 2003-04-10
AU2002241944A1 (en) 2002-07-30

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