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WO2002056941A3 - Method for the treatment of peripheral vascular disease - Google Patents

Method for the treatment of peripheral vascular disease Download PDF

Info

Publication number
WO2002056941A3
WO2002056941A3 PCT/US2002/003852 US0203852W WO02056941A3 WO 2002056941 A3 WO2002056941 A3 WO 2002056941A3 US 0203852 W US0203852 W US 0203852W WO 02056941 A3 WO02056941 A3 WO 02056941A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
vascular disease
peripheral vascular
mammal
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/003852
Other languages
French (fr)
Other versions
WO2002056941A2 (en
Inventor
Theodore M Danoff
Jeffrey Granett
Diane K Jorkasky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to AU2002250044A priority Critical patent/AU2002250044A1/en
Publication of WO2002056941A2 publication Critical patent/WO2002056941A2/en
Publication of WO2002056941A3 publication Critical patent/WO2002056941A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention provides a method for the prevention or reduction of vascular access dysfunction in association with the insertion or repair of an indwelling shunt, fistula or catheter into a vein, in a mammal, preferably a human, or in the treatment of peripheral vascular disease in a mammal, particularly a human, in need thereof, which comprises administering to the subject N-(3',4'-dimethoxycinnamoyl)anthranilic acid or a pharmaceutically acceptable salt thereof in a dose of from about 0.1 mg to about 2,400 mg.
PCT/US2002/003852 2001-01-19 2002-01-17 Method for the treatment of peripheral vascular disease Ceased WO2002056941A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002250044A AU2002250044A1 (en) 2001-01-19 2002-01-17 Method for the treatment of peripheral vascular disease

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US26286101P 2001-01-19 2001-01-19
US60/262,861 2001-01-19
US26829301P 2001-02-13 2001-02-13
US60/268,293 2001-02-13
US26898601P 2001-02-15 2001-02-15
US60/268,986 2001-02-15

Publications (2)

Publication Number Publication Date
WO2002056941A2 WO2002056941A2 (en) 2002-07-25
WO2002056941A3 true WO2002056941A3 (en) 2003-03-27

Family

ID=27401546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003852 Ceased WO2002056941A2 (en) 2001-01-19 2002-01-17 Method for the treatment of peripheral vascular disease

Country Status (2)

Country Link
AU (1) AU2002250044A1 (en)
WO (1) WO2002056941A2 (en)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ATHEROSCLEROSIS, vol. 118, no. 2, December 1995 (1995-12-01), pages 213 - 221 *
CIRCULATION, vol. 99, no. 7, 23 February 1999 (1999-02-23), pages 919 - 924 *
DATABASE MEDLINE [online] (COLUMBUS, OH, USA); CAPPER, E.A. ET AL.: "Modulation of human monocyte activities by tranilast, ST 252218, a compound demonstrating efficacy in restenosis", XP002953930, accession no. STN Database accession no. 2001056667 *
DATABASE MEDLINE [online] (COLUMBUS, OH, USA); MATSUMURA, T. ET AL.: "Suppression of atherosclerotic development in watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast", XP002953929, accession no. STN Database accession no. 1999152078 *
DATABASE MEDLINE [online] (COLUMBUS, OH, USA); MIYAZAWA, K. ET AL.: "Inhibition of PDGF- and TGF-beta 1-induced collagen synthesis, migration and proliferation by tranilast in vascular smooth muscle cells from spontaneously hypertensive rats", XP002953931, accession no. STN Database accession no. 96366138 *
J. PHARMACOL. EXPER. THER., vol. 295, no. 3, December 2000 (2000-12-01), pages 1061 - 1069 *

Also Published As

Publication number Publication date
AU2002250044A1 (en) 2002-07-30
WO2002056941A2 (en) 2002-07-25

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