WO2002056849A1 - Hair growth stimulants - Google Patents

Abstract

Hair growth stimulants comprising an oil-in-water type emulsion wherein particles comprising oily hair growth stimulating components effective in hair growth (ethynylestradiol, hinokitiol, etc.) and fat components such as squalane and dl-α-tocopherol acetate are suspended in a state of having an average particle diameter of 100 nm or less. These hair growth stimulants can easily penetrate into the scalp and effectively stimulate hair growth without damaging the scalp or hair.

Description

Hair restorer technical field

 The present invention relates to a hair restorer. Background art

 Originally, the scalp is an extension of the skin of the face, and the fact that the hair itself is composed of keratin proteins similar to skin improves the scalp that is the soil of the hair. Growing and becoming dandruff and falling off) is an important element of hair growth. In other words, it is important for hair growth to improve the rhythm of the scalp cycle (which we call the scalp rhythm) and restore it to the normal cycle just like the hair cycle.

 Conventionally, hair growth and hair growth have been theoretically developed by focusing on the hair matrix, hair follicles, sebaceous glands, etc., where hair is generated. Development has been carried out. Therefore, products are generally produced in a state where active ingredients effective for hair growth are dissolved in a solvent such as water or alcohol.

 While applying this type of hair restorer to the scalp, it is conceivable that a very small amount would penetrate through the pores, but would not penetrate the scalp, and most would remain on the scalp, Only the solvent such as water or alcohol evaporates, resulting in crystals containing the active ingredient remaining, which cannot improve the rhythm of the scalp.

For those who are prone to thinning hair and baldness, which require a hair restorer, the sebaceous gland activity is activated and the scalp is often greasy. In other words, sebum is originally a butter-like fat, and is usually emulsified in the sebum film by appropriate control. However, if sebum is abnormally formed, the milky dung effect does not catch up, and sebum Is a peracidi There is a problem that it becomes lunar, worsens the environment of the scalp, closes the pores, and makes it more difficult for the hair restorer to penetrate through the pores.

 Therefore, before applying the hair restorer to the scalp, first carefully wash the hair with a special shampoo etc. that removes sebum in the pores, or put the scalp with a brush etc. before applying the hair restorer to the scalp Although a method to make the hair restorer easily penetrate has been proposed, it is time-consuming to carefully shampoo and putt before applying the hair restorer. In addition, even if a special shampoo is used, the sebum inside the pores cannot be sufficiently removed, so that it is not very effective, and if the hair is carefully washed, the hair and the scalp may be damaged and the effect may be adversely affected. . On the other hand, in the case of putting, the capillaries feeding the hair root are very thin, so if you put the scalp too strongly with a brush or the like, the capillaries will be crushed instead, and nourish the hair. There is a problem that can not be sent.

 In view of such circumstances, an object of the present invention is to provide a hair restorer that can easily penetrate into the scalp and efficiently grow hair without damaging the scalp or hair. Disclosure of the invention

 In order to achieve such an object, the hair restorer according to the present invention has an oily hair restorer component and a fat component effective for hair restorer having an average of 300 nm or less (more preferably 100 nm or less). The composition contains an emulsified product emulsified to a particle size of

 In the hair restorer of the present invention, it is preferable that the emulsion is diluted with an aqueous solution in which a water-soluble hair restorer is dissolved, as described in claim 2.

 The emulsion is not particularly limited. For example, the emulsion can be produced by using a known micro-mouth emulsifier such as a high-pressure homogenizer.

The oily hair restoring ingredient is not particularly limited, and cephalatin, nicotinic acid amide, benzyl nicotinate, salicylic acid, and aceti, which have been conventionally used as a hair restorative, are used. Known compounds such as lupantoturyl ether, Photosensitizer No. 301 and the like can be used. However, as described in Claim 3, the compound should contain at least one of ethurestradiol and hinokitiol. Is preferred. The fat component is not particularly limited, and known components such as jojoba oil and glyceryl tri-2-ethylhexanoate, which have been conventionally used as a hair restorer, can be used. It is preferable to include at least one of squalane d 1 -heat towel as shown in FIG.

 The water-soluble hair-growing component is not particularly limited, and includes dipotassium glycyrrhizinate, pantoturethyl ether, sodium salt of d1-pyrrolidonecarboxylic acid, trimethylglycine, sorbit solution, glycine and the like, which have been conventionally used as a hair-growth agent. Such known ones can be used, but as described in claim 5, at least one selected from the group consisting of alanine, proline, serine, threonine, anoreginin, lysine, and glutamic acid. Is preferred.

 Further, other additives such as surfactants, stabilizers, fragrances, coloring agents, preservatives, humectants, and fresheners are added to the hair restorer of the present invention to the extent that the hair restorer effect is not impaired. You can.

 The surface active agent is not particularly limited, but includes, for example, polyoxyethylene hardened castor oil, N-stearoyl mono-L-monosodium glutamate, polyoxyethylene sorbitan monooleate, and polyoxetylene cholestanol ether. Is mentioned. BEST MODE FOR CARRYING OUT THE INVENTION

 Hereinafter, embodiments of the present invention will be described in detail.

The hair restorer according to the present invention has an average particle size of not more than 300 nm (more preferably, not more than 300 nm, which is composed of ethurest radioisole and hinokitiol as oily hair restorer effective for hair restorer, and squalane and d1-α-tocopherol acetate as fat component). Emulsion containing 100 nm or less suspended particles (alanine, proline, serine ', threonine) It is dispersed in an aqueous solution containing water-soluble active ingredients such as arginine, arginine, lysine, and glutamic acid to form a tonic.

 As described above, this hair restorer has an average particle size of 300 nm or less (more preferably, 100 nm or less) in suspended particles composed of an oily hair growth component and a fat component effective for hair growth. However, the active ingredient penetrates into the inside of the skin by sewing the gaps in the lamella structure of the scalp, which did not penetrate with the conventional hair restorer.

 Therefore, disturbance of the rhythm of the scalp can be improved, and hair can be efficiently grown.

 What's more, shampooing etc. only needs to be done lightly, so that shampooing will not damage your hair.

 Also, putting with a brush is not required, and the problem of crushing capillaries and no longer feeding nutrition to hair is eliminated. Example

 Hereinafter, examples of the present invention will be described in more detail.

 (Example 1)

 The following ingredients were mixed using a high-pressure homogenizer (-210C-E / H, manufactured by Microfluidics) as an emulsifier at 30 ° C and a pressure of 20500 PSI (1435 kg m2), and the whole amount was passed once. Thus, a 0 / W emulsion was obtained.

 (Ingredients of emulsion)

 · Oil-based hair growth ingredient

 Etchininorestaradionore 0.0 2 parts by weight

• Fat component

Scotran 6.0 direct parts Acetic acid dl-ct-tocofue 2.5 parts by weight Glyceryl tri-2-ethylhexanoate 1.0 parts by weight Methinolepolysiloxane 10.0 parts by weight • Surfactant

 N-stearoyl L-sodium glutamate 0.40 parts by weight Polyoxyethylene cholestanol ether 2.50 parts by weight

• Other moisturizing ingredients 25.0 parts by weight

(Glycerin, 1,3-butylene glycol, sorbite solution, alcohol) • Purified water 50.5 8 parts by weight The average particle size of the suspended particles of the emulsion obtained as described above was determined by Otsuka Electronics Co., Ltd. It was 100 nm on average when measured using the laser particle size analysis system PAR-IIIs.

 Then, the obtained emulsion and an aqueous solution of a water-soluble active ingredient having the following composition were mixed with a stirrer (Satake Co., Ltd.) so that the ratio of 2.0 parts by weight of the noodles and 98.0 parts by weight of the aqueous solution was obtained. The mixture was stirred with a Portable Mixer Model A 520V) to obtain a tonic hair restorer.

 (Aqueous solution)

 0.4% by weight of alanine

 • Proline 0.1 parts by weight

 • Serine 1.5 parts by weight

 • 0.2% by weight of thread

 • Arginine 0.35 parts by weight

 • 0.7 parts by weight of lysine

 • 0.75 parts by weight daldamic acid

 • 38.38.5 parts by weight of purified water

(Example 2)

The same blending components as in Example 1 were mixed using a high-pressure homogenizer (-210 CE / H, manufactured by Microfluidics) at 30 ° C. and a pressure of 20500 PSI (1435 kg / cra2). A tonic hair restorer was obtained in the same manner as in Example 1 except that a / W emulsion was obtained. The particle size of the suspended particles of the obtained emulsion was measured in the same manner as in Example 1 and found to be 80 nm on average.

 (Comparative Example 1)

 Using a TK homomixer (arkll manufactured by Tokushu Kika Kogyo Co., Ltd.) as an emulsifying device, the same ingredients as in Example 1 were stirred at 30 ° C. and 7,000 rpm for 3 minutes to form a 0 / W type. Except that the emulsion was obtained, the same as in Example 1 except that the mixture was mixed at a pressure of R. PM20500PSI (1435 kg / cm2) and the whole amount was passed twice to obtain a 0 / W milky-drink. Thus, a tonic hair restorer was obtained.

 The average particle diameter of the suspended particles of the obtained emulsion was 500 nm when measured in the same manner as in Example 1. Industrial applicability

 Since the hair restorer according to the present invention is constituted as described above, it not only acts on the root of the hair, but also penetrates into the scalp without damaging the scalp, and exhibits a large hair restorer effect. The scalp does not require elaborate cleaning of the scalp with shampoo or scalp putting with a brush before application to the scalp.

Claims

The scope of the claims 1. A hair restorer containing an oil-in-water emulsion having an average particle diameter of 300 nm or less of suspended particles comprising an oily hair restorer and a fat component effective for hair restorer.  2. The hair restorer according to claim 1, wherein the emulsion is diluted with an aqueous solution in which a water-soluble hair restorer is dissolved.  3. The hair restorer according to claim 1 or 2, wherein the oily hair restorer comprises at least one or more of ethelestradiol and hinokitiol.  4. The hair restorer according to any one of claims 1 to 3, wherein the fat component contains at least one of squalane and acetic acid d1_α-tocopherol, or any one of them. 5. The method according to any one of claims 2 to 4, wherein the water-soluble hair growth component contains at least one selected from the group consisting of alanine, proline, serine, threonine, arginine, lysine, and glutamic acid. Hair restorer.