[go: up one dir, main page]

WO2002055071A8 - Compositions et methodes de regulation du taux de lipoproteines et de l'hypercholesterolemie au moyen de limonoides, de flavonoides et de tocotrienols - Google Patents

Compositions et methodes de regulation du taux de lipoproteines et de l'hypercholesterolemie au moyen de limonoides, de flavonoides et de tocotrienols

Info

Publication number
WO2002055071A8
WO2002055071A8 PCT/IB2001/000256 IB0100256W WO02055071A8 WO 2002055071 A8 WO2002055071 A8 WO 2002055071A8 IB 0100256 W IB0100256 W IB 0100256W WO 02055071 A8 WO02055071 A8 WO 02055071A8
Authority
WO
WIPO (PCT)
Prior art keywords
hypercholesterolmia
limonoids
tocotrienols
methods
lipoproteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/000256
Other languages
English (en)
Other versions
WO2002055071A1 (fr
Inventor
Najla Guthrie
Elzbieta Maria Kurowska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KGK Synergize Inc
Original Assignee
KGK Synergize Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KGK Synergize Inc filed Critical KGK Synergize Inc
Priority to PCT/IB2001/000256 priority Critical patent/WO2002055071A1/fr
Priority to AU2001232182A priority patent/AU2001232182A1/en
Publication of WO2002055071A1 publication Critical patent/WO2002055071A1/fr
Publication of WO2002055071A8 publication Critical patent/WO2002055071A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Cette invention concerne une composition et des méthodes permettant de prévenir et de traiter l'hypercholestérolémie, l'hyperlipidémie et l'athérosclérose. Des individus présentant un risque élevé de développer ou de contracter l'hypercholestérolémie et l'athérosclérose, et suivant des thérapies classiques, peuvent être traités à l'aide d'une dose efficace de dérivés triperpènes contenus dans des composés de limonoïdes, de flavonoïdes polyphénoliques, dans des tocotriénols ou dans une combinaison de ces agents.
PCT/IB2001/000256 2001-01-15 2001-01-15 Compositions et methodes de regulation du taux de lipoproteines et de l'hypercholesterolemie au moyen de limonoides, de flavonoides et de tocotrienols Ceased WO2002055071A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IB2001/000256 WO2002055071A1 (fr) 2001-01-15 2001-01-15 Compositions et methodes de regulation du taux de lipoproteines et de l'hypercholesterolemie au moyen de limonoides, de flavonoides et de tocotrienols
AU2001232182A AU2001232182A1 (en) 2001-01-15 2001-01-15 Compositions and methods for regulating lipoproteins and hypercholesterolmia with limonoids flavonoids and tocotrienols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2001/000256 WO2002055071A1 (fr) 2001-01-15 2001-01-15 Compositions et methodes de regulation du taux de lipoproteines et de l'hypercholesterolemie au moyen de limonoides, de flavonoides et de tocotrienols

Publications (2)

Publication Number Publication Date
WO2002055071A1 WO2002055071A1 (fr) 2002-07-18
WO2002055071A8 true WO2002055071A8 (fr) 2002-08-15

Family

ID=11004047

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/000256 Ceased WO2002055071A1 (fr) 2001-01-15 2001-01-15 Compositions et methodes de regulation du taux de lipoproteines et de l'hypercholesterolemie au moyen de limonoides, de flavonoides et de tocotrienols

Country Status (2)

Country Link
AU (1) AU2001232182A1 (fr)
WO (1) WO2002055071A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987125B1 (en) 1998-10-06 2006-01-17 The United States Of America As Represented By The Secretary Of Agriculture Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones
NZ529243A (en) * 2001-05-02 2007-11-30 Kgk Synergize Inc Use of polymethoxylated flavones for treating insulin resistance
CA2567969A1 (fr) * 2004-05-26 2005-12-08 Kgk Synergize Inc. Compositions contenant des flavonoides et des tocotrienols et methodes associees
EP1748773A4 (fr) * 2004-05-26 2008-11-12 Kgk Synergize Inc Aliments fonctionnels comprenant des flavonoides et des tocotrienols et procedes associes
JP5473191B2 (ja) 2004-11-08 2014-04-16 アークレイ株式会社 ペルオキシソーム増殖剤応答性受容体（ｐｐａｒ）活性化剤、ならびにそれを用いた医薬、サプリメント、機能性食品および食品添加物
WO2007093853A2 (fr) * 2005-11-10 2007-08-23 Kgk Synergize Inc Compositions et méthodes de traitement et prévention du syndrome métabolique et des troubles par des combinaison de limonoïdes, flavonoïdes et tocotriénols
ATE510538T1 (de) 2006-08-11 2011-06-15 Univ Johns Hopkins Zusammensetzungen und verfahren für nervenschutz

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603142A (en) * 1984-06-01 1986-07-29 Wisconsin Alumni Research Foundation Cholesterol lowering method of use
US5217992A (en) * 1989-10-04 1993-06-08 Bristol-Myers Squibb Company Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
KR100213895B1 (ko) * 1996-10-14 1999-08-02 박원훈 감귤류 과피 추출물, 이로부터 분리 정제된 헤스페리딘 또는 나린진을 포함하는 심혈관 질환 예방및 치료제 조성물
US6251400B1 (en) * 1997-09-26 2001-06-26 Kgk Synergize Inc Compositions and methods of treatment of neoplastic diseases and hypercholesterolemia with citrus limonoids and flavonoids and tocotrienols
CA2307553C (fr) * 1997-10-28 2003-06-17 Korea Institute Of Science And Technology Extrait d'ecorce d'agrumes en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophage-lipide sur les parois arterielles et agent de prevention ou de traitement des maladies hepatiques
ID28460A (id) * 1998-07-08 2001-05-24 Lipogenics Inc Komposisi dan metoda untuk perlakuan dan pencegahan penyakit tulang dengan menggunakan tocotrienol

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose

Also Published As

Publication number Publication date
WO2002055071A1 (fr) 2002-07-18
AU2001232182A1 (en) 2002-07-24

Similar Documents

Publication Publication Date Title
WO2001051043A3 (fr) Compositions et methodes de traitement de maladies neoplasiques au moyen de combinaisons de limonoides, de flavonoides et de tocotrienols
WO1999015167A3 (fr) Utilisation de limonoides et de flavonoides d'agrumes et de tocotrienols pour le traitement du cancer
WO2002072031A3 (fr) Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
IL138476A0 (en) Method for treating pharmaceutical compositions by special use of anti-oxidant
BR0206639A (pt) Combinações de inibidor(es) da absorção do esterol com modificador(es) do sangue para o tratamento de condições vasculares
WO1999063977A3 (fr) Composition pharmaceutique destinee a traiter ou prevenir les troubles du sommeil
IL125735A (en) Pharmaceutical compositions for the treatment of glaucoma comprising an inhibitor of serine-threonine kinase, tyrosine kinase or protein tyrosine phosphatase or an actin-disrupting compound
EP1128832A4 (fr) Composes, compositions et procedes pour traiter des infections virales et les maladies qui y sont liees
NO20024610L (no) Synergistiske metoder og blandinger for behandling av kreft
DK1369039T3 (da) Synergistiske herbicide fremgangsmåder
WO2003026643A3 (fr) Methodes et combinaisons therapeutiques utiles pour le traitement du xanthome effectue avec des inhibiteurs d'absorption du sterol
WO2001030333A3 (fr) Antagonistes de facteur tissulaire et leurs procedes d'utilisation
WO2002039994A3 (fr) Methodes de traitement et de prevention des calculs urinaires
AU2001284413A1 (en) Medicinal compositions for preventing or treating heart failure
WO2004043456A8 (fr) Inhibiteurs d'absorption du cholesterol pour le traitement de la demyelination
WO2002055530A3 (fr) Conjugues de fixation au recepteur de transcobalamine utiles pour le traitement d'une proliferation cellulaire anormale
WO1998036730A3 (fr) Compositions de traitement de l'acne rosacee
WO2002055071A8 (fr) Compositions et methodes de regulation du taux de lipoproteines et de l'hypercholesterolemie au moyen de limonoides, de flavonoides et de tocotrienols
ZA200003768B (en) Methods and compositions for treating diseases and conditions of the eye.
WO2005096704A3 (fr) Composition hypocholesterolemiante
PT796618E (pt) Tratamento e profilaxia da pancreatite
WO2002041831A3 (fr) Derives d'inositol augmentant la secretion de chrolure et freinant l'inflammation
ZA200309642B (en) Benzo (G) quinoline derivatives for treating glaucoma and myopia.
FI961380A7 (fi) Koostumuksia virusten aiheuttamien kasvainten ehkäisemiseksi ja hoitam iseksi
AU2002320352A1 (en) Methods for treating or preventing sclerotic disorders using cd2-binding agents

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 29/2002 UNDER (51) AFTER "A61K 31/365" REPLACE "A61K 31/353, A61K 31/353" BY "A61K 31/353, A61K 31/355"

Free format text: PAT. BUL. 29/2002 UNDER (51) AFTER "A61K 31/365" REPLACE "A61K 31/353, A61K 31/353" BY "A61K 31/353, A61K 31/355"

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase in:

Ref country code: JP