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WO2002047615A3 - Oral compositions and use thereof - Google Patents

Oral compositions and use thereof Download PDF

Info

Publication number
WO2002047615A3
WO2002047615A3 PCT/US2001/049032 US0149032W WO0247615A3 WO 2002047615 A3 WO2002047615 A3 WO 2002047615A3 US 0149032 W US0149032 W US 0149032W WO 0247615 A3 WO0247615 A3 WO 0247615A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibiting
oral
dental
terpenoid
candidiasis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/049032
Other languages
French (fr)
Other versions
WO2002047615A2 (en
Inventor
William H Bowen
Hyun Koo
Yong Kun Park
Jaime Aparecido Cury
Pedro Luiz Rosalen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Estadual de Campinas UNICAMP
University of Rochester
Original Assignee
Universidade Estadual de Campinas UNICAMP
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Estadual de Campinas UNICAMP, University of Rochester filed Critical Universidade Estadual de Campinas UNICAMP
Priority to AU2002231030A priority Critical patent/AU2002231030A1/en
Priority to CA002431044A priority patent/CA2431044A1/en
Priority to JP2002549191A priority patent/JP2004521880A/en
Priority to US10/450,231 priority patent/US20040057908A1/en
Priority to EP01991293A priority patent/EP1399119A2/en
Publication of WO2002047615A2 publication Critical patent/WO2002047615A2/en
Anticipated expiration legal-status Critical
Publication of WO2002047615A3 publication Critical patent/WO2002047615A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to an oral composition which includes an organoleptically suitable carrier and an amount of a terpenoid and a flavonoid, dispersed in the carrier, which is effective to prevent or treat dental caries, dental plaque formation, gingivitis, candidiasis, dental stomatitis, aphthous ulceration, or fungal infection. The invention also relates to various uses of oral compositions, containing a terpenoid, a flavonoid, or both, such uses include: inhibiting the activity of surface-bound glusosyltransferase; treating or inhibiting dental caries, gingivitis, candidiasis, denture stomatitis; inhibiting the accumulation of microorganisms on an oral surface; and/or treating or inhibiting aphthous ulcerations on an oral surface.
PCT/US2001/049032 2000-12-13 2001-12-13 Oral compositions and use thereof Ceased WO2002047615A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2002231030A AU2002231030A1 (en) 2000-12-13 2001-12-13 Oral compositions and use thereof
CA002431044A CA2431044A1 (en) 2000-12-13 2001-12-13 Oral compositions and use thereof
JP2002549191A JP2004521880A (en) 2000-12-13 2001-12-13 Oral composition and method of using the same
US10/450,231 US20040057908A1 (en) 2001-12-13 2001-12-13 Oral compositions and use thereof
EP01991293A EP1399119A2 (en) 2000-12-13 2001-12-13 Oral compositions and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25530400P 2000-12-13 2000-12-13
US60/255,304 2000-12-13

Publications (2)

Publication Number Publication Date
WO2002047615A2 WO2002047615A2 (en) 2002-06-20
WO2002047615A3 true WO2002047615A3 (en) 2003-12-31

Family

ID=22967716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/049032 Ceased WO2002047615A2 (en) 2000-12-13 2001-12-13 Oral compositions and use thereof

Country Status (5)

Country Link
EP (1) EP1399119A2 (en)
JP (1) JP2004521880A (en)
AU (1) AU2002231030A1 (en)
CA (1) CA2431044A1 (en)
WO (1) WO2002047615A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945518B2 (en) 2002-04-30 2015-02-03 Unigen, Inc. Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1604741A (en) * 2001-12-18 2005-04-06 汉高两合股份公司 Adhesion inhibition of moulds
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
CN100544715C (en) 2002-04-30 2009-09-30 尤尼根制药公司 Compositions comprising a mixture of free-B-ring flavonoids and flavans as therapeutic agents
WO2004089392A1 (en) 2003-04-04 2004-10-21 Unigen Pharmaceuticals, Inc. Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care
KR20060022279A (en) 2003-06-17 2006-03-09 헨켈 코만디트게젤샤프트 아우프 악티엔 Inhibition of fungal asexual reproduction by eugenol and / or derivatives thereof
ES2921427T3 (en) 2004-01-23 2022-08-25 Eden Research Plc Nematode elimination methods that comprise the application of an encapsulated terpene component
ES2434415T3 (en) 2004-05-20 2013-12-16 Eden Research Plc Compositions containing a hollow glucan particle or a cell wall particle encapsulating a terpene component, methods for its manufacture and use.
TW200630102A (en) * 2004-10-19 2006-09-01 Unigen Pharmaceuticals Inc Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions
US7258878B2 (en) * 2004-12-20 2007-08-21 Kimberly-Clark Worldwide, Inc. Anti-microbial composition and methods of use thereof
AR052840A1 (en) * 2004-12-22 2007-04-04 Colgate Palmolive Co COMPOSITIONS FOR ORAL CARE CONTAINING FLAVONOIDS AND FLAVANS
US20060140881A1 (en) * 2004-12-22 2006-06-29 Guofeng Xu Oral care compositions containing flavonoids and flavans
US20060134015A1 (en) 2004-12-22 2006-06-22 Trivedi Harsh M Methods for use of oral care compositions containing free-B-ring flavonoid anti-oxidants
GB0514943D0 (en) * 2005-07-20 2005-08-24 Botan Ltd Oral care compositions
EP2368442B1 (en) 2005-07-27 2014-12-17 Symrise AG Use of hesperetin for enhancing the sweet taste
JP2007091706A (en) * 2005-08-30 2007-04-12 Kao Corp Biofilm inhibitor
US20070140990A1 (en) * 2005-12-21 2007-06-21 Nataly Fetissova Oral Compositions Comprising Propolis
EP1994928A4 (en) * 2006-03-10 2010-08-11 Yuuzou Tsuchida Antimicrobial agent and antimicrobial composition
FI121468B (en) * 2006-06-07 2010-11-30 Valtion Teknillinen Compounds derived from betulin as antimicrobial agents
GB0614353D0 (en) 2006-07-20 2006-08-30 Oraldent Ltd Oral compositions, their preparation and use
KR100761248B1 (en) 2006-10-12 2007-10-04 주식회사 유니젠 Composition for the treatment of atopic dermatitis containing bamboo and golden extract as active ingredients
CA2688570A1 (en) * 2007-05-31 2008-12-04 F.P.L. Pharma Inc. Compositions for prevention or treatment of anorexia-cachexia syndrome and uses thereof
KR101409266B1 (en) * 2011-11-24 2014-06-24 영남대학교 산학협력단 Inhibitors of Biofilm and Methods therefor
KR101685671B1 (en) * 2012-09-27 2016-12-12 한국 한의학 연구원 Pharmaceutical composition for preventing or treating peridontal disease comprising extract of Lignum Acronychiae containing nerolidol
CN105163728B (en) * 2013-04-05 2018-10-02 蜜纽康新西兰有限公司 Therapeutic compositions comprising propolis extracts and uses thereof
CN104721066B (en) 2013-12-19 2018-08-07 高露洁-棕榄公司 Make the method for rutin solubilising with multi-hydroxy alkyl alcohol
KR101597645B1 (en) * 2014-02-12 2016-02-25 재단법인 진안홍삼연구소 A pharmaceutical composition containing acacetin as a active ingredient for the treatment of dental caries and peridontal disease
CL2014000767A1 (en) * 2014-03-28 2014-06-20 Univ Concepcion Tissue conditioning kit comprising terpenic anti fungal with activity against oral candidiasis present in subprotesis stomatitis
TW201609113A (en) * 2014-07-18 2016-03-16 歐文 約翰 蓋奇波 Therapeutic composition and use thereof
CA2961376A1 (en) * 2014-09-15 2016-03-24 Vizuri Health Sciences Llc Polyphenol/flavonoid compositions and methods of formulating oral hygienic products
WO2017048617A1 (en) * 2015-09-15 2017-03-23 Vizuri Health Sciences Llc Polyphenol/flavonoid compositions and methods of formulating oral hygienic products
RU2688231C1 (en) * 2019-02-19 2019-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации Method of treating leptopothia in the oral cavity
JP7620483B2 (en) * 2020-06-25 2025-01-23 大木製▲薬▼株式会社 Oral flora improver
GR1010909B (en) * 2023-11-13 2025-03-17 Frezyderm A.B.E.E. Καλλυντικα - Φαρμακα - Ειδη Διατροφης, Compositions of hygiene orally-administrated luteolin-containing formulation for the treatment of inflammatory periodontal diseases - production method of the same

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382886A (en) * 1981-04-13 1983-05-10 Sosnowski Zenon M Method for extracting propolis and water soluble dry propolis powder
US4748022A (en) * 1985-03-25 1988-05-31 Busciglio John A Topical composition
US5116602A (en) * 1989-09-27 1992-05-26 Colgate-Palmolive Company Antiplaque oral compositions
US5472684A (en) * 1993-06-02 1995-12-05 Colgate Palmolive Company Oral compositions for plaque and gingivitis
US5529779A (en) * 1991-08-27 1996-06-25 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Purified propolis-extract, and its preparation and uses
US5561116A (en) * 1991-04-11 1996-10-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Solid product containing propolis components, and preparation and uses thereof
US5922324A (en) * 1995-01-31 1999-07-13 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Propolis extract with improved water-solubility
US6027716A (en) * 1997-04-02 2000-02-22 Farmo-Nat Ltd. Synergistic herbal extracts
US6153227A (en) * 1998-07-31 2000-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Propolis extract
US6159450A (en) * 1996-10-25 2000-12-12 Societe De Conseils De Recherches Et D'applications Scientifiques S.C.R.A.S. Use of Ginkgo biloba flavonoidic extract substantially devoid of terpenes for oral hygiene and composition containing such extract

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382886A (en) * 1981-04-13 1983-05-10 Sosnowski Zenon M Method for extracting propolis and water soluble dry propolis powder
US4748022A (en) * 1985-03-25 1988-05-31 Busciglio John A Topical composition
US5116602A (en) * 1989-09-27 1992-05-26 Colgate-Palmolive Company Antiplaque oral compositions
US5561116A (en) * 1991-04-11 1996-10-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Solid product containing propolis components, and preparation and uses thereof
US5529779A (en) * 1991-08-27 1996-06-25 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Purified propolis-extract, and its preparation and uses
US5472684A (en) * 1993-06-02 1995-12-05 Colgate Palmolive Company Oral compositions for plaque and gingivitis
US5922324A (en) * 1995-01-31 1999-07-13 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Propolis extract with improved water-solubility
US6159450A (en) * 1996-10-25 2000-12-12 Societe De Conseils De Recherches Et D'applications Scientifiques S.C.R.A.S. Use of Ginkgo biloba flavonoidic extract substantially devoid of terpenes for oral hygiene and composition containing such extract
US6027716A (en) * 1997-04-02 2000-02-22 Farmo-Nat Ltd. Synergistic herbal extracts
US6153227A (en) * 1998-07-31 2000-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Propolis extract
US6153228A (en) * 1998-07-31 2000-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Propolis extract

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945518B2 (en) 2002-04-30 2015-02-03 Unigen, Inc. Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions

Also Published As

Publication number Publication date
WO2002047615A2 (en) 2002-06-20
AU2002231030A1 (en) 2002-06-24
JP2004521880A (en) 2004-07-22
CA2431044A1 (en) 2002-06-20
EP1399119A2 (en) 2004-03-24

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