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WO2002046466A3 - Complexes of brca and stat polypeptides and methods of use in the detection and treatment of cancer - Google Patents

Complexes of brca and stat polypeptides and methods of use in the detection and treatment of cancer Download PDF

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Publication number
WO2002046466A3
WO2002046466A3 PCT/IB2001/002797 IB0102797W WO0246466A3 WO 2002046466 A3 WO2002046466 A3 WO 2002046466A3 IB 0102797 W IB0102797 W IB 0102797W WO 0246466 A3 WO0246466 A3 WO 0246466A3
Authority
WO
WIPO (PCT)
Prior art keywords
brca
amount
stat
activity
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/002797
Other languages
French (fr)
Other versions
WO2002046466A2 (en
Inventor
Sigridur Valgeirsdottir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICELAND GENOMICS Corp
Original Assignee
ICELAND GENOMICS Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICELAND GENOMICS Corp filed Critical ICELAND GENOMICS Corp
Priority to AU2002233572A priority Critical patent/AU2002233572A1/en
Publication of WO2002046466A2 publication Critical patent/WO2002046466A2/en
Publication of WO2002046466A3 publication Critical patent/WO2002046466A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a method of inhibiting cellular proliferation mediated by a BRCA/STAT complex. The method consists of contacting a BRCA/STAT- containing cell with an effective amount of a BRCA/STAT complex modulating compound sufficient to modulate the amount or activity of a BRCA/STAT complex in the cell. The invention also provides a method of reducing the severity of cancer. The method consists of administering to an individual an effective amount of a BRCA/STAT complex modulating compound sufficient to modulate the amount or activity of a BRCA/STAT complex in cancer cells in the individual. Also provided are methods of detecting the risk of breast cancer in an individual. In one embodiment, the method consists of detecting an amount or activity of a BRCA/STAT complex in a sample obtained from an individual suspected of having breast cancer and comparing the amount or activity of the BRCA/STAT complex from the sample to an amount or activity form a reference sample, a difference in the amount or activity between the sample and the reference sample indicating the presence or susceptibility of breast cancer. The invention also provides methods of prognosing the severity or progression of breast cancer.
PCT/IB2001/002797 2000-12-04 2001-12-04 Complexes of brca and stat polypeptides and methods of use in the detection and treatment of cancer Ceased WO2002046466A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002233572A AU2002233572A1 (en) 2000-12-04 2001-12-04 Complexes of brca and stat polypeptides and methods of use in the detection and treatment of cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25148400P 2000-12-04 2000-12-04
US60/251,484 2000-12-04

Publications (2)

Publication Number Publication Date
WO2002046466A2 WO2002046466A2 (en) 2002-06-13
WO2002046466A3 true WO2002046466A3 (en) 2003-02-13

Family

ID=22952160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/002797 Ceased WO2002046466A2 (en) 2000-12-04 2001-12-04 Complexes of brca and stat polypeptides and methods of use in the detection and treatment of cancer

Country Status (2)

Country Link
AU (1) AU2002233572A1 (en)
WO (1) WO2002046466A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176303B2 (en) 2003-11-06 2007-02-13 Isis Pharmaceuticals, Inc. Modulation of STAT5 expression
JP2009502913A (en) * 2005-07-27 2009-01-29 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Regulator
WO2010037224A1 (en) 2008-10-03 2010-04-08 St. Michael's Hospital Method for preventing and treating cardiovascular diseases with brca1

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIN GAO ET AL: "Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 488, no. 3, 5 January 2001 (2001-01-05), pages 179 - 184, XP004337942, ISSN: 0014-5793 *
HORVATH C M: "STAT proteins and transcriptional responses to extracellular signals", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 25, no. 10, 1 October 2000 (2000-10-01), pages 496 - 502, XP004224290, ISSN: 0968-0004 *
JACQUELINE BROMBERG: "SIgnal transducers and activators of transcription as regulators of growth, apoptosis and breast development.", BREAST CANCER RES., vol. 2, 2000, pages 86 - 90, XP002902723 *
ROBYN CATLETT-FALCONE ET AL: "STAT proteins as novel targets for cancer therapy", CURRENT OPINION IN ONCOLOGY, vol. 11, 1999, pages 490 - 496, XP002902722, ISSN: 1040-8746 *
TORU OUCHI ET AL: "Collaboration of signal transducer and activator of transcription 1(STAT1) and BRCA1 in differential regulation of IFN- gamma target genes.", PROC. NATL ACAD. SCI., vol. 97, no. 10, 9 May 2000 (2000-05-09), USA, pages 5208 - 5213, XP002902721 *

Also Published As

Publication number Publication date
WO2002046466A2 (en) 2002-06-13
AU2002233572A1 (en) 2002-06-18

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