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WO2002045746A3 - Composiciones farmaceuticas para potenciar la inmunogenicidad de antigenos poco inmunogenicos - Google Patents

Composiciones farmaceuticas para potenciar la inmunogenicidad de antigenos poco inmunogenicos Download PDF

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Publication number
WO2002045746A3
WO2002045746A3 PCT/CU2001/000010 CU0100010W WO0245746A3 WO 2002045746 A3 WO2002045746 A3 WO 2002045746A3 CU 0100010 W CU0100010 W CU 0100010W WO 0245746 A3 WO0245746 A3 WO 0245746A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunogenicity
pharmaceutical compositions
compositions disclosed
poorly immunogenic
immunogenic antigens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CU2001/000010
Other languages
English (en)
French (fr)
Other versions
WO2002045746A2 (es
Inventor
Molina Luis Enrique Fernandez
Ramirez Belinda Sanchez
Pestana Eduardo Raul Suarez
La Barrera Aira Anabel De
Pardillo Circe Mesa
Leon Delgado Joel De
Rodriguez Yildian Diaz
Rodriguez Rolando Perez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro de Immunologia Molecular
Original Assignee
Centro de Immunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CU20000285A external-priority patent/CU23000A1/es
Priority claimed from CU20010167A external-priority patent/CU23009A1/es
Priority to AU2002221519A priority Critical patent/AU2002221519B2/en
Priority to KR1020037007634A priority patent/KR100850473B1/ko
Priority to BR0116013-3 priority patent/BRPI0116013B8/pt
Priority to JP2002547529A priority patent/JP4210519B2/ja
Priority to AU2151902A priority patent/AU2151902A/xx
Priority to CA2431188A priority patent/CA2431188C/en
Priority to EA200300640A priority patent/EA005138B1/ru
Priority to EP01999387A priority patent/EP1356822B1/en
Application filed by Centro de Immunologia Molecular filed Critical Centro de Immunologia Molecular
Priority to DE60143363T priority patent/DE60143363D1/de
Priority to HK04106497.1A priority patent/HK1063726B/xx
Priority to MXPA03005032A priority patent/MXPA03005032A/es
Priority to DK01999387.2T priority patent/DK1356822T3/da
Priority to AT01999387T priority patent/ATE485833T1/de
Publication of WO2002045746A2 publication Critical patent/WO2002045746A2/es
Publication of WO2002045746A3 publication Critical patent/WO2002045746A3/es
Priority to NZ526282A priority patent/NZ526282A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se relaciona con la Inmunología y más específicamente con composiciones inmunogénicas que contienen péptidos, polipéptidos, proteínas, sus correspondientes secuencias de ADN, células o sus lisados y proteoliposomas de muy pequeña talla (VSSP), formados estos últimos al unir el complejo de proteínas de la membrana externa (CPME) de Neisseria meningitidis con gangliósidos, mediante enlaces hidrófobos. En particular esta invención muestra como preparar composiciones inmunoestimuladoras capaces de generar respuestas inmunes antígeno-específicas inclusive en huéspedes inmunocomprometidos, como son los que padecen de cáncer e infecciones de origen viral o bacterianas crónicas. En estos pacientes, la administración de las composiciones vacunales descritas permite restaurar la funcionalidad de sectores de su sistema inmunitario. Las composiciones vacunales de esta invención pueden ser utilizadas para proteger de o tratar enfermedades infecciosas, malignas o autoinmunes.
PCT/CU2001/000010 2000-12-06 2001-12-06 Composiciones farmaceuticas para potenciar la inmunogenicidad de antigenos poco inmunogenicos Ceased WO2002045746A2 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DK01999387.2T DK1356822T3 (da) 2000-12-06 2001-12-06 Farmaceutiske sammensætninger, der forøger immunogeniteten af svagt immunogene antigener
AT01999387T ATE485833T1 (de) 2000-12-06 2001-12-06 Pharmazeutische zusammensetzungen, die die immunogenität von schwach immunogenen antigenen fördern
DE60143363T DE60143363D1 (de) 2000-12-06 2001-12-06 Pharmazeutische zusammensetzungen, die die immunogenität von schwach immunogenen antigenen fördern
BR0116013-3 BRPI0116013B8 (pt) 2000-12-06 2001-12-06 composição farmacêutica para potenciar a imunogenicidade de antígenos pouco imunogênicos, e, uso da composição farmacêutica
JP2002547529A JP4210519B2 (ja) 2000-12-06 2001-12-06 低免疫原性抗原の免疫原性を増強する医薬組成物
AU2151902A AU2151902A (en) 2000-12-06 2001-12-06 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens
CA2431188A CA2431188C (en) 2000-12-06 2001-12-06 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens
EA200300640A EA005138B1 (ru) 2000-12-06 2001-12-06 Фармацевтические композиции, усиливающие иммуногенность антигенов со слабой иммуногенностью
EP01999387A EP1356822B1 (en) 2000-12-06 2001-12-06 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens
AU2002221519A AU2002221519B2 (en) 2000-12-06 2001-12-06 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens
KR1020037007634A KR100850473B1 (ko) 2000-12-06 2001-12-06 면역원성이 불량한 항원의 면역원성을 향상시키는 약제조성물
HK04106497.1A HK1063726B (en) 2000-12-06 2001-12-06 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens
MXPA03005032A MXPA03005032A (es) 2000-12-06 2001-12-06 Composiciones farmaceuticas para potenciar inmunogenicidad de antigenos poco inmunogenicos.
NZ526282A NZ526282A (en) 2000-12-06 2003-06-04 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CU20000285A CU23000A1 (es) 2000-12-06 2000-12-06 Composiciones vacunales para la inmunoterapia activa específica del cáncer
CU285/2000 2000-12-06
CU167/2001 2001-07-12
CU20010167A CU23009A1 (es) 2001-07-12 2001-07-12 Preparaciones para potenciar la inmunogenicidad depreparaciones para potenciar la inmunogenicidad de antígenos poco inmunogénicos antígenos poco inmunogénicos

Publications (2)

Publication Number Publication Date
WO2002045746A2 WO2002045746A2 (es) 2002-06-13
WO2002045746A3 true WO2002045746A3 (es) 2002-12-27

Family

ID=38812545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2001/000010 Ceased WO2002045746A2 (es) 2000-12-06 2001-12-06 Composiciones farmaceuticas para potenciar la inmunogenicidad de antigenos poco inmunogenicos

Country Status (19)

Country Link
US (1) US7776342B2 (es)
EP (1) EP1356822B1 (es)
JP (1) JP4210519B2 (es)
KR (1) KR100850473B1 (es)
CN (1) CN1291755C (es)
AR (1) AR031638A1 (es)
AT (1) ATE485833T1 (es)
AU (2) AU2002221519B2 (es)
BR (1) BRPI0116013B8 (es)
CA (1) CA2431188C (es)
DE (1) DE60143363D1 (es)
DK (1) DK1356822T3 (es)
EA (1) EA005138B1 (es)
MX (1) MXPA03005032A (es)
NZ (1) NZ526282A (es)
PE (1) PE20020572A1 (es)
UY (1) UY27059A1 (es)
WO (1) WO2002045746A2 (es)
ZA (1) ZA200304411B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1367395A1 (de) * 2002-05-02 2003-12-03 B.R.A.H.M.S Aktiengesellschaft Diagnose von Neoplasmen mit Hilfe von anti-Gangliosid-Antikörpern
EP1358910A1 (de) * 2002-05-02 2003-11-05 B.R.A.H.M.S Aktiengesellschaft Verfahren und Mittel zur Prävention, Hemmung und Therapie von Krebserkrankungen
CU23257A1 (es) * 2003-02-27 2008-01-24 Centro Inmunologia Molecular COMPOSICIONES VACUNALES A BASE DE GANGLIOSIDOS PARA LA ADMINISTRACION SUBCUTáNEA
AR045815A1 (es) * 2003-10-09 2005-11-16 Ct Ingenieria Genetica Biotech Composiciones farmaceuticas que contienen antigenos del virus de papiloma humano
WO2005111079A2 (en) * 2004-05-14 2005-11-24 The United States Of America As Represented By The Secretary Department Of Health And Human Services Hiv vaccine immunogens and immunization strategies to elicit broadly-neutralizing anti-hiv-1 antibodies against the membrane proximal domain of hiv gp41
WO2010003219A1 (en) * 2008-06-17 2010-01-14 Universite Laval Compositions comprising salmonella porins and uses thereof as adjuvants and vaccines
LT2654785T (lt) * 2010-12-22 2019-07-10 Bayer Intellectual Property Gmbh Sustiprintas galvijų imuninis atsakas
KR101323845B1 (ko) * 2011-01-21 2013-10-31 광주과학기술원 외막소포체를 유효성분으로 포함하는 항암용 약제학적 조성물
CU24070B1 (es) * 2011-12-27 2015-01-29 Ct De Inmunología Molecular Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3)
JP6873530B2 (ja) * 2013-03-15 2021-05-19 イン3バイオ・リミテッドIn3Bio Ltd. 自己組織化合成タンパク質（Ｓｅｌｆ−Ａｓｓｅｍｂｌｉｎｇ Ｓｙｎｔｈｅｔｉｃ Ｐｒｏｔｅｉｎｓ）
CU24299B1 (es) * 2013-08-02 2017-12-08 Centro De Inmunología Molecular Composiciones vacunales bivalentes basadas en los receptores de tipo 1 y 2 del factor de crecimiento epidérmico
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
US10105306B2 (en) * 2013-09-17 2018-10-23 Bestop Group Holdings Limited Method of preparing a growth factor concentrate
EP3116893B1 (en) * 2014-03-11 2019-08-28 Jacques Fantini A chimeric peptide that interacts with cell membrane gangliosides
US12019073B2 (en) * 2017-03-15 2024-06-25 Centro De Inmunologia Molecular Method for the treatment of patients with carcinomas
AU2018234783B2 (en) 2017-03-15 2024-10-24 Centro De Inmunologia Molecular Method for the treatment of patients with carcinomas
EP3688026A4 (en) * 2017-09-27 2021-11-10 L2 Diagnostics, LLC PHARMACEUTICAL AND VACCINAL COMPOSITIONS BASED ON PEPTIDE ERBB AND THEIR THERAPEUTIC USES FOR THE TREATMENT OF CANCER
CU24534B1 (es) * 2017-11-06 2021-07-02 Ct Inmunologia Molecular Adyuvantes nano-particulados que contienen variantes sintéticas del gangliósido gm3
CU20170173A7 (es) * 2017-12-27 2019-11-04 Ct Inmunologia Molecular Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras
CN109865137A (zh) * 2019-01-23 2019-06-11 天德悦（北京）生物科技有限责任公司 经碘代乙酰基活化的琼脂糖微球在提高多肽或蛋白类免疫原免疫原性中的应用

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EP0283443A2 (en) * 1987-02-18 1988-09-21 Istituto Farmacoterapico Italiano S.P.A. Process for extracting membrane antigens having immunogenic properties from human neoplastic cells and products thereby obtained
EP0657471A1 (en) * 1993-12-09 1995-06-14 Centro de Inmunologia Molecular Anti ganglioside monoclonal antibodies and their use in the specific active immunotherapy of malignant tumours
WO1999036085A1 (en) * 1998-01-16 1999-07-22 Biomira Usa Inc. Patient-specific white blood cell malignancy vaccine from membrane-proteoliposomes

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Also Published As

Publication number Publication date
AU2151902A (en) 2002-06-18
NZ526282A (en) 2005-01-28
JP2004523494A (ja) 2004-08-05
HK1063726A1 (en) 2005-01-14
EA200300640A1 (ru) 2003-12-25
ATE485833T1 (de) 2010-11-15
DE60143363D1 (de) 2010-12-09
EA005138B1 (ru) 2004-12-30
AR031638A1 (es) 2003-09-24
DK1356822T3 (da) 2011-02-07
US7776342B2 (en) 2010-08-17
US20020136735A1 (en) 2002-09-26
AU2002221519B2 (en) 2006-11-23
UY27059A1 (es) 2002-04-26
KR20030061838A (ko) 2003-07-22
CN1291755C (zh) 2006-12-27
BRPI0116013B1 (pt) 2018-07-24
ZA200304411B (en) 2004-07-29
JP4210519B2 (ja) 2009-01-21
EP1356822B1 (en) 2010-10-27
CA2431188C (en) 2010-09-07
BR0116013A (pt) 2004-01-06
MXPA03005032A (es) 2004-09-10
EP1356822A2 (en) 2003-10-29
WO2002045746A2 (es) 2002-06-13
BRPI0116013B8 (pt) 2021-05-25
KR100850473B1 (ko) 2008-08-07
CN1484532A (zh) 2004-03-24
PE20020572A1 (es) 2002-07-31
CA2431188A1 (en) 2002-06-13

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