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WO2002042428A3 - Plant production of camptothecins and related compounds - Google Patents

Plant production of camptothecins and related compounds Download PDF

Info

Publication number
WO2002042428A3
WO2002042428A3 PCT/US2001/050941 US0150941W WO0242428A3 WO 2002042428 A3 WO2002042428 A3 WO 2002042428A3 US 0150941 W US0150941 W US 0150941W WO 0242428 A3 WO0242428 A3 WO 0242428A3
Authority
WO
WIPO (PCT)
Prior art keywords
camptothecins
related compounds
plant
glandular trichomes
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/050941
Other languages
French (fr)
Other versions
WO2002042428A2 (en
Inventor
Shiyou Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stephen F Austin State University
Original Assignee
Stephen F Austin State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stephen F Austin State University filed Critical Stephen F Austin State University
Priority to AU2002241753A priority Critical patent/AU2002241753A1/en
Publication of WO2002042428A2 publication Critical patent/WO2002042428A2/en
Publication of WO2002042428A3 publication Critical patent/WO2002042428A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/005—Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Botany (AREA)
  • Environmental Sciences (AREA)
  • Cultivation Of Plants (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention provides a system for increasing the production of indole and quinoline alkaloids, particularly camptothecins and related compounds, in plants, based upon management of plant hormones. This invention includes a system and a method for accelerating the growth of young tissues, inducing the production of camptothecins-bearing glandular trichomes, maximizing the harvest of glandular trichomes, and preserving and treating the glandular trichomes for maximum camptothecins yield. The present invention is useful for any plant matters containing alkaloids, regardless of the plant matters' genetic origin, natural or cultivated variety, and natural or cultivated growing conditions.
PCT/US2001/050941 2000-10-25 2001-10-23 Plant production of camptothecins and related compounds Ceased WO2002042428A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002241753A AU2002241753A1 (en) 2000-10-25 2001-10-23 Plant production of camptothecins and related compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69604200A 2000-10-25 2000-10-25
US09/696,042 2000-10-25

Publications (2)

Publication Number Publication Date
WO2002042428A2 WO2002042428A2 (en) 2002-05-30
WO2002042428A3 true WO2002042428A3 (en) 2003-04-17

Family

ID=24795468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050941 Ceased WO2002042428A2 (en) 2000-10-25 2001-10-23 Plant production of camptothecins and related compounds

Country Status (3)

Country Link
AU (1) AU2002241753A1 (en)
TW (1) TW500599B (en)
WO (1) WO2002042428A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103975668B (en) * 2014-03-30 2015-03-25 东北林业大学 Method for improving content of 10-methoxycamptothecine in Camptotheca acuminata seeds
WO2017083490A1 (en) 2015-11-11 2017-05-18 Stephen F. Austin State University Plant varieties by application of endocides
CN120584762A (en) * 2025-05-30 2025-09-05 云南昕科药业有限公司 A highly efficient in vitro accumulation method for camptothecin

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BALDWIN I.T.: "Phytochemical Induction by Herbivores", 1991, JOHN WILEY & SONS, INC, article "Damage induced alkaloids in wild Tobacco", pages: 47 - 70, XP002960043 *
BALDWIN I.T.: "The alkaloidal responses of wild Tobacco to real and simulated herbivory", OECOLOGIA, vol. 77, 1998, pages 378 - 381, XP002960042 *
BEDKER P.J. ET AL: "How to prune trees. NA-FR-01-95, forest service, USDA", FOREST SEVICE USDA, 1995, pages 1 - 17, XP002960077 *
BRYANT J.P. ET AL: "Carbon/nutrient balance of boreal plants in relation to vertebrate herbivory", OKIOS, vol. 40, 1983, pages 357 - 368, XP001051366 *
COOK A.D.: "Brooklyn Botanical Garden", 1991, NEW YORK, NY, article "Pruning techniques", XP002960041 *
GERSHENZON ET AL: "Biosynthetic methods for plant natural products: new procedures for the study of glandular trichome constitutients in modern phytochemical methods", 1991, pages 347 - 370, XP002960045 *
LI S.Y. ET AL: "A Henry M. Rockwell monograph", 1994, STEPHEN F. AUSTIN STATE UNIVERSITY, NACOGDOCHES TX, article "Camptotheca acuminata decaisne, XI shu, a promising anti-cancer and anti-viral tree for the 21st century", pages: 1 - 268 *
LIU Z. ET AL: "Variations in the secondary metabolite camptothecin in relation to tissue age and season in camptotheca acuminata", TREE PHYSIOLOGY, vol. 18, 1998, pages 265 - 270, XP002960040 *
LOPEZ-MYER M. ET AL.: "Sites of accumulation of the antitumor alkaloid camptothecin in camptotheca acuminata", PLANT MEDICA, vol. 60, 1994, pages 558 - 560, XP002946022 *
MEDIC K.: "Pruning - Rodale's successful organic gardening", 1995, RODALE PRESS, EMMAUS *
PERDUE R.E.: "Chinese tree yields cancer-inhibiting drug", May 1970 (1970-05-01) - June 1970 (1970-06-01), pages 1 - 3, XP002960078 *
VAN HENGEL ET AL: "Characterization of callus formation and camptothecin production by cell lines of camptotheca acuminata", PLANT CELL TISSUE AND ORGAN CULTURE, vol. 28, no. 1, January 1992 (1992-01-01), pages 11 - 18, XP002960044 *
VINCENT R.M. ET AL: "Sustained harvest of camptothecin from the leaves of camptotheca acuminata", JOURNAL OF NATURAL PRODUCTS, vol. 60, 1997, pages 618 - 619, XP002946018 *

Also Published As

Publication number Publication date
AU2002241753A1 (en) 2002-06-03
TW500599B (en) 2002-09-01
WO2002042428A2 (en) 2002-05-30

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