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WO2002040029A3 - Adduits de corticosteroides comprenant des polymeres polysaccharidiques naturels - Google Patents

Adduits de corticosteroides comprenant des polymeres polysaccharidiques naturels Download PDF

Info

Publication number
WO2002040029A3
WO2002040029A3 PCT/IB2001/002170 IB0102170W WO0240029A3 WO 2002040029 A3 WO2002040029 A3 WO 2002040029A3 IB 0102170 W IB0102170 W IB 0102170W WO 0240029 A3 WO0240029 A3 WO 0240029A3
Authority
WO
WIPO (PCT)
Prior art keywords
adducts
corticosteroids
natural polysaccharide
polysaccharide polymers
possess
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/002170
Other languages
English (en)
Other versions
WO2002040029A2 (fr
Inventor
Piergiorgio Anzaghi
Rosanna Stefli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMA BIOTECH Ltd
Original Assignee
PHARMA BIOTECH Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHARMA BIOTECH Ltd filed Critical PHARMA BIOTECH Ltd
Priority to AU2002212630A priority Critical patent/AU2002212630A1/en
Publication of WO2002040029A2 publication Critical patent/WO2002040029A2/fr
Publication of WO2002040029A3 publication Critical patent/WO2002040029A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

L'invention concerne des adduits de polysaccharides naturels comprenant des médicaments corticostéroïdes sous forme de solutions aqueuses ou à l'état solide, sous forme de poudre. Ces adduits présentent une efficacité thérapeutique identique à celle de l'ingrédient actif seul utilisé dans les mêmes quantités. Ceux-ci présentent donc une toxicité inférieure pour une activé anti-inflammatoire égale. Ces nouveaux adduits sont obtenus par un processus de réalisation simple qui permet de réduire leur coût.
PCT/IB2001/002170 2000-11-17 2001-11-16 Adduits de corticosteroides comprenant des polymeres polysaccharidiques naturels Ceased WO2002040029A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002212630A AU2002212630A1 (en) 2000-11-17 2001-11-16 Corticosteroids adducts with natural polysaccharide polymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2000A002477 2000-11-17
IT2000MI002477A IT1319665B1 (it) 2000-11-17 2000-11-17 Addotti di corticosteroidi con polimeri polisaccaridici naturali.

Publications (2)

Publication Number Publication Date
WO2002040029A2 WO2002040029A2 (fr) 2002-05-23
WO2002040029A3 true WO2002040029A3 (fr) 2002-10-31

Family

ID=11446118

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/002170 Ceased WO2002040029A2 (fr) 2000-11-17 2001-11-16 Adduits de corticosteroides comprenant des polymeres polysaccharidiques naturels

Country Status (3)

Country Link
AU (1) AU2002212630A1 (fr)
IT (1) IT1319665B1 (fr)
WO (1) WO2002040029A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032054A1 (it) 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
CN103705470B (zh) * 2014-01-06 2015-06-17 南通大学 一种负载甲强龙的纳米微球及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009592A1 (fr) * 1989-12-21 1991-07-11 Kabi Pharmacia Ab Systeme transdermique
WO1992011037A2 (fr) * 1990-12-19 1992-07-09 Advanced Magnetics Inc. Ciblage d'agents therapeutiques au moyen de polysaccharides
EP0780129A2 (fr) * 1995-12-11 1997-06-25 CAC Corporation Composition thérapeutique à usage externe contenant des corticostéroides adrénals pour le traitement des dermatites

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009592A1 (fr) * 1989-12-21 1991-07-11 Kabi Pharmacia Ab Systeme transdermique
WO1992011037A2 (fr) * 1990-12-19 1992-07-09 Advanced Magnetics Inc. Ciblage d'agents therapeutiques au moyen de polysaccharides
EP0780129A2 (fr) * 1995-12-11 1997-06-25 CAC Corporation Composition thérapeutique à usage externe contenant des corticostéroides adrénals pour le traitement des dermatites

Also Published As

Publication number Publication date
WO2002040029A2 (fr) 2002-05-23
AU2002212630A1 (en) 2002-05-27
IT1319665B1 (it) 2003-10-23
ITMI20002477A1 (it) 2002-05-17

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