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WO2001039819A3 - Method and apparatus for closed recirculation of synthetic cerebrospinal fluid - Google Patents

Method and apparatus for closed recirculation of synthetic cerebrospinal fluid Download PDF

Info

Publication number
WO2001039819A3
WO2001039819A3 PCT/US2000/042473 US0042473W WO0139819A3 WO 2001039819 A3 WO2001039819 A3 WO 2001039819A3 US 0042473 W US0042473 W US 0042473W WO 0139819 A3 WO0139819 A3 WO 0139819A3
Authority
WO
WIPO (PCT)
Prior art keywords
cerebrospinal fluid
closed recirculation
csf
equipment
cassette
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/042473
Other languages
French (fr)
Other versions
WO2001039819A2 (en
Inventor
Glenn Frazer
Timothy J Pelura
Bruce Shook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuron Therapeutics Inc
Original Assignee
Neuron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuron Therapeutics Inc filed Critical Neuron Therapeutics Inc
Priority to KR1020027007066A priority Critical patent/KR20020077351A/en
Priority to EP00992584A priority patent/EP1235602A2/en
Priority to CA002393221A priority patent/CA2393221A1/en
Priority to AU45127/01A priority patent/AU4512701A/en
Priority to JP2001541549A priority patent/JP2003515394A/en
Publication of WO2001039819A2 publication Critical patent/WO2001039819A2/en
Publication of WO2001039819A3 publication Critical patent/WO2001039819A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0229—Devices operating in a closed circuit, i.e. recycling the irrigating fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0204—Physical characteristics of the irrigation fluid, e.g. conductivity or turbidity
    • A61M3/0216—Pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M2027/004—Implant devices for drainage of body fluids from one part of the body to another with at least a part of the circuit outside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/0476—Oxygenated solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3344—Measuring or controlling pressure at the body treatment site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0201—Cassettes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
    • A61M3/0258—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped by means of electric pumps

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Sustainable Development (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • External Artificial Organs (AREA)

Abstract

This generally relates to methods and apparatus for accomplishing the closed recirculation of cerebrospinal fluid (CSF), typically synthetic in nature, through the cerebral and spinal regions of the body and the replenishment and revitalization equipment. A preferred cassette variation includes a modular disposable package of equipment preferably packaged in such a way that it is readily and quickly employed in an emergency. The cassette preferably contains all or most of the components forming the fluid path which accomplishes the conditioning of the recirculated therapeutic CSF from and to the patient.
PCT/US2000/042473 1999-12-03 2000-12-01 Method and apparatus for closed recirculation of synthetic cerebrospinal fluid Ceased WO2001039819A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020027007066A KR20020077351A (en) 1999-12-03 2000-12-01 Method and apparatus for closed recirculation of synthetic cerebrospinal fluid
EP00992584A EP1235602A2 (en) 1999-12-03 2000-12-01 Method and apparatus for closed recirculation of synthetic cerebrospinal fluid
CA002393221A CA2393221A1 (en) 1999-12-03 2000-12-01 Method and apparatus for closed recirculation of synthetic cerebrospinal fluid
AU45127/01A AU4512701A (en) 1999-12-03 2000-12-01 Method and apparatus for closed recirculation of synthetic cerebrospinal fluid
JP2001541549A JP2003515394A (en) 1999-12-03 2000-12-01 Closed system recirculation method and apparatus for synthetic cerebrospinal fluid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45489399A 1999-12-03 1999-12-03
US09/454,893 1999-12-03

Publications (2)

Publication Number Publication Date
WO2001039819A2 WO2001039819A2 (en) 2001-06-07
WO2001039819A3 true WO2001039819A3 (en) 2002-03-14

Family

ID=23806494

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042473 Ceased WO2001039819A2 (en) 1999-12-03 2000-12-01 Method and apparatus for closed recirculation of synthetic cerebrospinal fluid

Country Status (7)

Country Link
EP (1) EP1235602A2 (en)
JP (1) JP2003515394A (en)
KR (1) KR20020077351A (en)
CN (1) CN1433328A (en)
AU (1) AU4512701A (en)
CA (1) CA2393221A1 (en)
WO (1) WO2001039819A2 (en)

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* Cited by examiner, † Cited by third party
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US6689756B2 (en) * 2001-03-02 2004-02-10 Integra Lifesciences Corporation Treatment of neurological disease
CA2411569A1 (en) * 2002-11-12 2004-05-12 Ross E. Mantle Medical device for the extravascular recirculation of fluid in body cavities at controlled temperature and pressure
US7004961B2 (en) * 2003-01-09 2006-02-28 Edward Wong Medical device and method for temperature control and treatment of the brain and spinal cord
EP1904140A1 (en) 2005-07-21 2008-04-02 The Cleveland Clinic Foundation Medical oscillating compliance devices and uses thereo
US7699799B2 (en) 2005-08-26 2010-04-20 Ceeben Systems, Inc. Ultrasonic material removal system for cardiopulmonary bypass and other applications
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US20180311071A1 (en) * 2005-10-21 2018-11-01 Daniel R. BURNETT Method and apparatus for peritoneal oxygenation
US8435204B2 (en) * 2006-10-09 2013-05-07 Neurofluidics, Inc. Cerebrospinal fluid purification system
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
US10695545B2 (en) 2006-10-09 2020-06-30 Minnetronix, Inc. Systems and methods for the conditioning of cerebrospinal fluid
US10569064B2 (en) 2013-03-13 2020-02-25 Minnetronix, Inc. Devices and methods for providing focal cooling to the brain and spinal cord
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
EP2155300A1 (en) 2007-04-05 2010-02-24 Velomedix, Inc Automated therapy system and method
US8123714B2 (en) * 2007-06-29 2012-02-28 Codman & Shurtleff, Inc. Programmable shunt with electromechanical valve actuator
CA2693774A1 (en) 2007-07-09 2009-01-15 Velomedix, Inc. Hypothermia devices and methods
WO2009058353A1 (en) 2007-11-02 2009-05-07 The Cleveland Clinic Foundation Device for increasing cerebral blood flow
WO2011114260A1 (en) * 2010-03-19 2011-09-22 Pfizer Inc. Cerebrospinal fluid purification system
US9622670B2 (en) 2010-07-09 2017-04-18 Potrero Medical, Inc. Method and apparatus for pressure measurement
CN103706025A (en) * 2013-12-23 2014-04-09 李桂亮 Embedded type subarachnoid space microscale slow-release syringe
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
EP3331586B1 (en) * 2015-08-05 2020-04-29 Minnetronix Inc. Tangential flow filter system for the filtration of materials from biologic fluids
AU2016333997B2 (en) * 2015-10-06 2019-06-06 Pharaoh Neuro, Inc. Devices and methods for providing focal cooling to the brain and spinal cord
CA3006975C (en) * 2015-12-04 2022-02-22 Minnetronix, Inc. Systems and methods for the conditioning of cerebrospinal fluid
EP3691730B1 (en) * 2017-10-05 2025-06-18 Minnetronix Inc. Systems for treating along the central nervous system
CN107993546B (en) * 2018-01-16 2019-09-06 西安市红会医院 An in vitro model of cerebrospinal fluid circulation and an in vitro simulation method for hydrocephalus
KR20220011123A (en) 2019-04-11 2022-01-27 엔클리어 테라피스, 인크. Cerebrospinal fluid improvement method and device and system therefor
US12337140B2 (en) 2020-09-29 2025-06-24 Enclear Therapies, Inc. Subarachnoid fluid management method and system with varying rates
CN110575573B (en) * 2019-09-24 2020-12-22 福建医科大学附属第一医院 A disposable pipeline installation system for continuous purification treatment of artificial cerebrospinal fluid
US11559626B2 (en) * 2020-04-08 2023-01-24 Medtronic, Inc. Means to treat Alzheimer's disease via flushing of brain parenchyma
WO2021231311A1 (en) 2020-05-11 2021-11-18 Minnetronix Neuro, Inc. Filtering cassettes and filtering systems
JPWO2022181126A1 (en) * 2021-02-26 2022-09-01
AU2022315184A1 (en) * 2021-07-19 2024-03-07 Enclear Therapies, Inc. Csf diagnostics platform
GR1010335B (en) * 2022-02-11 2022-11-09 Αναστασιος Γεωργιου Τσογκας Pneumocephalus prevention device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
WO1988008728A1 (en) * 1987-05-15 1988-11-17 The Dis Corporation Device and method for perfusing an animal head
WO1997032621A1 (en) * 1996-03-08 1997-09-12 Life Resuscitation Technologies, Inc. Liquid ventilation method and apparatus
US5716318A (en) * 1995-04-14 1998-02-10 The University Of North Carolina At Chapel Hill Method of treating cardiac arrest and apparatus for same

Family Cites Families (5)

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US4981691A (en) 1980-04-14 1991-01-01 Thomas Jefferson University Oxygenated fluorocarbon nutrient solution
US4378797A (en) 1980-04-14 1983-04-05 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US5772607A (en) 1995-06-06 1998-06-30 The Nemours Foundation Body fluid collection apparatus
US5823987A (en) 1996-01-11 1998-10-20 Medtronic, Inc. Compact membrane-type blood oxygenator with concentric heat exchanger
JP3803421B2 (en) 1996-04-26 2006-08-02 富士システムズ株式会社 Gas exchange device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
WO1988008728A1 (en) * 1987-05-15 1988-11-17 The Dis Corporation Device and method for perfusing an animal head
US5716318A (en) * 1995-04-14 1998-02-10 The University Of North Carolina At Chapel Hill Method of treating cardiac arrest and apparatus for same
WO1997032621A1 (en) * 1996-03-08 1997-09-12 Life Resuscitation Technologies, Inc. Liquid ventilation method and apparatus

Also Published As

Publication number Publication date
JP2003515394A (en) 2003-05-07
CN1433328A (en) 2003-07-30
CA2393221A1 (en) 2001-06-07
KR20020077351A (en) 2002-10-11
AU4512701A (en) 2001-06-12
EP1235602A2 (en) 2002-09-04
WO2001039819A2 (en) 2001-06-07

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