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WO2001036980A3 - Procede d'identification du site actif dans une cible biologique - Google Patents

Procede d'identification du site actif dans une cible biologique Download PDF

Info

Publication number
WO2001036980A3
WO2001036980A3 PCT/GB2000/004420 GB0004420W WO0136980A3 WO 2001036980 A3 WO2001036980 A3 WO 2001036980A3 GB 0004420 W GB0004420 W GB 0004420W WO 0136980 A3 WO0136980 A3 WO 0136980A3
Authority
WO
WIPO (PCT)
Prior art keywords
identifying
type
active site
biological target
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/004420
Other languages
English (en)
Other versions
WO2001036980A2 (fr
Inventor
Torbjoern Lundstedt
Per Andersson
Jarl Wikberg
Ruta Muceniece
Peteris Prusis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melacure Therapeutics AB
Original Assignee
Melacure Therapeutics AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melacure Therapeutics AB filed Critical Melacure Therapeutics AB
Priority to EP00977666A priority Critical patent/EP1232466A2/fr
Priority to NZ518980A priority patent/NZ518980A/en
Priority to AU15305/01A priority patent/AU1530501A/en
Priority to HK03101309.1A priority patent/HK1049218A1/zh
Priority to CA002392086A priority patent/CA2392086A1/fr
Publication of WO2001036980A2 publication Critical patent/WO2001036980A2/fr
Publication of WO2001036980A3 publication Critical patent/WO2001036980A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des procédés de caractérisation de sites d'interaction entre un ligand Y et une cible X. Ces procédés comprennent les étapes consistant à (1) entrer des informations sur les propriétés chimiques/physiques d'au moins deux cibles du type X; (2) entrer des informations sur les propriétés chimiques/physiques d'au moins deux ligands du type Y; (3) entrer des informations sur l'interaction entre au moins des cibles du type X avec au moins deux ligands du type Y; et mettre ensuite en corrélation les informations recueillies au cours des étapes 1, 2 et 3 au moyen d'une ou de plusieurs procédés multicritères de façon à créer un modèle d'interaction entre le ligand Y et la cible X, les sites d'interaction pouvant être identifiés et/ou caractérisés à partir de ce modèle.
PCT/GB2000/004420 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique Ceased WO2001036980A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP00977666A EP1232466A2 (fr) 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique
NZ518980A NZ518980A (en) 1999-11-18 2000-11-20 A process for identifying the active site in a biological target by producing a model of the interaction between a ligand and a target
AU15305/01A AU1530501A (en) 1999-11-18 2000-11-20 A process for identifying the active site in a biological target
HK03101309.1A HK1049218A1 (zh) 1999-11-18 2000-11-20 在生物主體內區別活性部位的方法
CA002392086A CA2392086A1 (fr) 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9927346.8A GB9927346D0 (en) 1999-11-18 1999-11-18 Method for analysis and design of entities of a chemical or biochemical nature
GB9927346.8 1999-11-18

Publications (2)

Publication Number Publication Date
WO2001036980A2 WO2001036980A2 (fr) 2001-05-25
WO2001036980A3 true WO2001036980A3 (fr) 2002-03-14

Family

ID=10864777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004420 Ceased WO2001036980A2 (fr) 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique

Country Status (8)

Country Link
EP (1) EP1232466A2 (fr)
AU (1) AU1530501A (fr)
CA (1) CA2392086A1 (fr)
GB (1) GB9927346D0 (fr)
HK (1) HK1049218A1 (fr)
NZ (1) NZ518980A (fr)
WO (1) WO2001036980A2 (fr)
ZA (1) ZA200203963B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4394279B2 (ja) 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体
SE9801571D0 (sv) 1998-05-05 1998-05-05 Wapharm Ab Melanokortin-1-receptorselektiva föreningar
AU2002231706A1 (en) * 2000-11-28 2002-06-11 Clairbio Capital Management Apparatus and method for determining affinity data between a target and a ligand
EP1209610A1 (fr) * 2000-11-28 2002-05-29 Valentin Capital Management Dispositif et procédé de détermination de données d'affinité entre une cible et un ligand
US20030158671A1 (en) * 2001-07-18 2003-08-21 Structural Genomix, Inc. Systems and methods for predicting active site residues in a protein
AU2002357683A1 (en) * 2001-11-02 2003-05-19 Arqule, Inc. Cyp2c9 binding models
DE10241793A1 (de) * 2002-09-06 2004-06-17 Roos, Gudrun, Dr. Vorrichtung zur Ermittlung der Wirksamkeit von Pflanzenextrakten
EP1919947B1 (fr) 2005-08-26 2013-02-27 AbbVie Inc. Analogues alpha-msh therapeutiquement actifs
WO2013163348A1 (fr) * 2012-04-24 2013-10-31 Laboratory Corporation Of America Holdings Procédés et systèmes d'identification d'un site de liaison protéique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587293A (en) * 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
WO1999006839A1 (fr) * 1997-08-01 1999-02-11 Novalon Pharmaceutical Corporation Procede d'identification et de developpement de chefs de file de medicaments
WO1999031267A1 (fr) * 1997-12-18 1999-06-24 Sepracor Inc. Techniques d'identification simultanee de nouvelles cibles biologiques et structures conductrices pour mise au point d'un medicament

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587293A (en) * 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
US5798275A (en) * 1994-01-06 1998-08-25 Terrapin Technologies, Inc. Profiling reference panel enriched by non-IG proteins
WO1999006839A1 (fr) * 1997-08-01 1999-02-11 Novalon Pharmaceutical Corporation Procede d'identification et de developpement de chefs de file de medicaments
WO1999031267A1 (fr) * 1997-12-18 1999-06-24 Sepracor Inc. Techniques d'identification simultanee de nouvelles cibles biologiques et structures conductrices pour mise au point d'un medicament

Also Published As

Publication number Publication date
EP1232466A2 (fr) 2002-08-21
ZA200203963B (en) 2003-05-19
CA2392086A1 (fr) 2001-05-25
WO2001036980A2 (fr) 2001-05-25
GB9927346D0 (en) 2000-01-12
AU1530501A (en) 2001-05-30
NZ518980A (en) 2005-05-27
HK1049218A1 (zh) 2003-05-02

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