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WO2001035989A3 - Verwendung von anti-idiotypische antikörpern als impfstoffe gegenkrebs - Google Patents

Verwendung von anti-idiotypische antikörpern als impfstoffe gegenkrebs Download PDF

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Publication number
WO2001035989A3
WO2001035989A3 PCT/EP2000/011306 EP0011306W WO0135989A3 WO 2001035989 A3 WO2001035989 A3 WO 2001035989A3 EP 0011306 W EP0011306 W EP 0011306W WO 0135989 A3 WO0135989 A3 WO 0135989A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
immuno
affinity purification
against cancer
vaccines against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/011306
Other languages
English (en)
French (fr)
Other versions
WO2001035989A2 (de
Inventor
Hans Loibner
Helmut Eckert
Gottfried Himmler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Igeneon Krebs-Immuntherapie Forschungs- und Entwicklungs-GmbH
Original Assignee
Igeneon Krebs-Immuntherapie Forschungs- und Entwicklungs-GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0015597-7A priority Critical patent/BR0015597A/pt
Priority to MXPA02004942A priority patent/MXPA02004942A/es
Priority to NZ518669A priority patent/NZ518669A/en
Priority to JP2001537979A priority patent/JP2003514028A/ja
Priority to AU23572/01A priority patent/AU780853B2/en
Priority to EEP200200252A priority patent/EE200200252A/xx
Priority to IL14961400A priority patent/IL149614A0/xx
Priority to SI200030390T priority patent/SI1229936T1/xx
Priority to EP00987250A priority patent/EP1229936B1/de
Priority to AT00987250T priority patent/ATE267020T1/de
Priority to HU0204216A priority patent/HUP0204216A2/hu
Application filed by Igeneon Krebs-Immuntherapie Forschungs- und Entwicklungs-GmbH filed Critical Igeneon Krebs-Immuntherapie Forschungs- und Entwicklungs-GmbH
Priority to CA002391927A priority patent/CA2391927A1/en
Priority to DE50006526T priority patent/DE50006526D1/de
Priority to PL00356770A priority patent/PL356770A1/xx
Priority to KR1020027006126A priority patent/KR20020060968A/ko
Priority to SK654-2002A priority patent/SK6542002A3/sk
Publication of WO2001035989A2 publication Critical patent/WO2001035989A2/de
Publication of WO2001035989A3 publication Critical patent/WO2001035989A3/de
Priority to IS6381A priority patent/IS6381A/is
Priority to NO20022333A priority patent/NO20022333L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Beschrieben wird die Verwendung von Antikörpern, die an Antikörper gegen Tumorassoziierte Antigene binden und die aus individuellen Körperflüssigkeiten durch Immunaffinitätsreinigung an spezifischen Liganden gewonnen werden, zur Herstellung einer Zusammensetzung zur individuellen, autologen prophylaktischen oder therapeutischen Vakzinierung gegen Krebserkrankungen. Die Liganden der Immunaffinitätsreinigung sind Antikörper oder deren Derivate, die gegen Tumorassoziierte Antigene gerichtet sind. Ferner betrifft die Erfindung pharmazeutische Zusammensetzungen, die die durch Immunaffinitätsreinigung erhaltenen Antikörper enthalten oder mit diesen in-vitro gepulste dendritische Zellen.
PCT/EP2000/011306 1999-11-16 2000-11-15 Verwendung von anti-idiotypische antikörpern als impfstoffe gegenkrebs Ceased WO2001035989A2 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
HU0204216A HUP0204216A2 (en) 1999-11-16 2000-11-15 A new use of antibodies as vaccines
NZ518669A NZ518669A (en) 1999-11-16 2000-11-15 Therapeutic or prophylactic vaccination against cancer using antibodies recovered from serum by immunoaffinity purification
JP2001537979A JP2003514028A (ja) 1999-11-16 2000-11-15 ワクチンとしての抗体の新たな使用
AU23572/01A AU780853B2 (en) 1999-11-16 2000-11-15 Use of anti-idiotypical antibodies as vaccines against cancer
EEP200200252A EE200200252A (et) 1999-11-16 2000-11-15 Antikehade kasutamine vaktsiinidena, antikehi sisaldavad farmatseutilised kompositsioonid, meetod antikehapreparaadi valmistamiseks ja meetod farmatseutilise kompositsiooni valmistamiseks
IL14961400A IL149614A0 (en) 1999-11-16 2000-11-15 Novel use of antibodies as vaccines
CA002391927A CA2391927A1 (en) 1999-11-16 2000-11-15 Novel use of antibodies as vaccines
MXPA02004942A MXPA02004942A (es) 1999-11-16 2000-11-15 Nuevo uso de anticuerpos como vacunas.
AT00987250T ATE267020T1 (de) 1999-11-16 2000-11-15 Verwendung von anti-idiotypischen antikörpern als impfstoffe gegen krebs
BR0015597-7A BR0015597A (pt) 1999-11-16 2000-11-15 Uso de anticorpos como vacinas
EP00987250A EP1229936B1 (de) 1999-11-16 2000-11-15 Verwendung von anti-idiotypischen antikörpern als impfstoffe gegen krebs
SI200030390T SI1229936T1 (en) 1999-11-16 2000-11-15 Use of anti-idiotypical antibodies as vaccines against cancer
DE50006526T DE50006526D1 (de) 1999-11-16 2000-11-15 Verwendung von anti-idiotypischen antikörpern als impfstoffe gegen krebs
PL00356770A PL356770A1 (en) 1999-11-16 2000-11-15 Use of anti-idiotypical antibodies as vaccines against cancer
KR1020027006126A KR20020060968A (ko) 1999-11-16 2000-11-15 백신으로서의 항체의 용도
SK654-2002A SK6542002A3 (en) 1999-11-16 2000-11-15 The use of antibodies for the production of pharmaceutical composition useful as vaccines
IS6381A IS6381A (is) 1999-11-16 2002-05-14 Nýjung við notkun mótefna í bóluefni
NO20022333A NO20022333L (no) 1999-11-16 2002-05-15 Ny anvendelse av antistoffer som vaksiner

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA-1927/99 1999-11-16
AT0192799A AT409086B (de) 1999-11-16 1999-11-16 Neue verwendung von antikörpern als impfstoffe

Publications (2)

Publication Number Publication Date
WO2001035989A2 WO2001035989A2 (de) 2001-05-25
WO2001035989A3 true WO2001035989A3 (de) 2001-10-04

Family

ID=3524036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/011306 Ceased WO2001035989A2 (de) 1999-11-16 2000-11-15 Verwendung von anti-idiotypische antikörpern als impfstoffe gegenkrebs

Country Status (24)

Country Link
EP (1) EP1229936B1 (de)
JP (1) JP2003514028A (de)
KR (1) KR20020060968A (de)
CN (1) CN1390138A (de)
AT (1) AT409086B (de)
AU (1) AU780853B2 (de)
BR (1) BR0015597A (de)
CA (1) CA2391927A1 (de)
CZ (1) CZ20021707A3 (de)
DE (1) DE50006526D1 (de)
DK (1) DK1229936T3 (de)
EE (1) EE200200252A (de)
ES (1) ES2218272T3 (de)
HU (1) HUP0204216A2 (de)
IL (1) IL149614A0 (de)
IS (1) IS6381A (de)
MX (1) MXPA02004942A (de)
NO (1) NO20022333L (de)
NZ (1) NZ518669A (de)
PL (1) PL356770A1 (de)
PT (1) PT1229936E (de)
SK (1) SK6542002A3 (de)
TR (1) TR200401267T4 (de)
WO (1) WO2001035989A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11583582B2 (en) 2007-10-05 2023-02-21 Immutep Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017108A (en) * 1975-04-17 1977-04-12 Archibald Kenrick And Sons Limited Window stay
US6294171B2 (en) * 1999-09-14 2001-09-25 Milkhaus Laboratory, Inc. Methods for treating disease states comprising administration of low levels of antibodies
AT410172B (de) * 2000-03-21 2003-02-25 Igeneon Gmbh Verfahren zur herstellung einer vakzineformulierung
AT410637B (de) * 2001-06-01 2003-06-25 Igeneon Krebs Immuntherapie Verwendung von polyklonalen immunglobulinen
AT502293B1 (de) * 2002-05-15 2008-03-15 Igeneon Krebs Immuntherapie Immunogener, monoklonaler antikörper
AT500648B1 (de) * 2002-08-12 2010-03-15 Igeneon Krebs Immuntherapie Set zur behandlung von krebspatienten
KR100522526B1 (ko) * 2002-11-28 2005-10-19 주식회사 바이넥스 면역 치료용 수지상 세포의 제조방법
AT500650B1 (de) 2003-04-17 2009-11-15 Altropus Gmbh Immunogener rekombinanter antikörper
WO2007024825A2 (en) * 2005-08-26 2007-03-01 Genway Biotech, Inc. Immunoaffinity separation and analysis compositions and methods
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
US20180008702A1 (en) * 2014-12-05 2018-01-11 Celltrion Inc. Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002848A1 (en) * 1983-01-28 1984-08-02 Centocor Inc Anti-idiotypic antibodies to t cell antigen receptors
WO1989011296A1 (en) * 1988-05-17 1989-11-30 Raychaudhuri, Syamal Anti-idiotype antibodies to anti-human high molecular weight-melanoma associated antigen
WO1991013632A1 (en) * 1990-03-14 1991-09-19 The Immune Response Corporation Idiotypic vaccination against b cell lymphoma
US5679356A (en) * 1992-07-08 1997-10-21 Schering Corporation Use of GM-CSF as a vaccine adjuvant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254315B (it) * 1992-03-27 1995-09-14 Mini Ricerca Scient Tecnolog Anticorpi monoclonali anti-idiotipici diretti contro anticorpi anti-tnf.
WO1996020219A2 (en) * 1994-12-28 1996-07-04 University Of Kentucky Murine monoclonal anti-idiotype antibody 3h1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002848A1 (en) * 1983-01-28 1984-08-02 Centocor Inc Anti-idiotypic antibodies to t cell antigen receptors
WO1989011296A1 (en) * 1988-05-17 1989-11-30 Raychaudhuri, Syamal Anti-idiotype antibodies to anti-human high molecular weight-melanoma associated antigen
WO1991013632A1 (en) * 1990-03-14 1991-09-19 The Immune Response Corporation Idiotypic vaccination against b cell lymphoma
US5679356A (en) * 1992-07-08 1997-10-21 Schering Corporation Use of GM-CSF as a vaccine adjuvant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FAGERBERG J ET AL: "HUMAN ANTI-IDIOTYPIC ANTIBODIES INDUCED A HUMORAL AND CELLULAR IMMUNE RESPONSE AGAINST A COLORECTAL CARCINOMA-ASSOCIATED ANTIGEN IN PATIENTS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 92, no. 11, 23 May 1995 (1995-05-23), pages 4773 - 4777, XP000566332, ISSN: 0027-8424 *
LOSMAN M J ET AL: "Human response against NP-4, a mouse antibody to carcinoembryonic antigen: human anti-idiotype antibodies mimic an epitope on the tumor antigen", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 88, no. 8, 15 April 1991 (1991-04-15), pages 3421 - 3425, XP002147167, ISSN: 0027-8424 *
M SALEH ET AL: "Generation of a human anti-idiotypic antibody that mimics the GD2 antigen", JOURNAL OF IMMUNOLOGY,US,THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 151, no. 6, 15 September 1993 (1993-09-15), pages 3390 - 3398, XP002091381, ISSN: 0022-1767 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11583582B2 (en) 2007-10-05 2023-02-21 Immutep Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response

Also Published As

Publication number Publication date
EP1229936B1 (de) 2004-05-19
PT1229936E (pt) 2004-09-30
BR0015597A (pt) 2002-07-23
AT409086B (de) 2002-05-27
EP1229936A2 (de) 2002-08-14
ES2218272T3 (es) 2004-11-16
CA2391927A1 (en) 2001-05-25
NO20022333L (no) 2002-06-03
TR200401267T4 (tr) 2004-07-21
NO20022333D0 (no) 2002-05-15
AU780853B2 (en) 2005-04-21
AU2357201A (en) 2001-05-30
CZ20021707A3 (cs) 2002-10-16
MXPA02004942A (es) 2003-10-14
DK1229936T3 (da) 2004-08-30
NZ518669A (en) 2003-08-29
PL356770A1 (en) 2004-07-12
ATA192799A (de) 2001-10-15
KR20020060968A (ko) 2002-07-19
WO2001035989A2 (de) 2001-05-25
IL149614A0 (en) 2002-11-10
JP2003514028A (ja) 2003-04-15
IS6381A (is) 2002-05-14
EE200200252A (et) 2003-06-16
CN1390138A (zh) 2003-01-08
HUP0204216A2 (en) 2003-04-28
SK6542002A3 (en) 2002-11-06
DE50006526D1 (de) 2004-06-24

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