WO2001034102A1 - Scalp and hair care compositions - Google Patents

Abstract

Scalp and hair care compositions containing: (a) one or more tyrosinase activity promoters; (b) one or more penetration promoters and/or blood flow promoters; (c) one or more hair folliculus activators; and (d) one or more 5α-reductase inhibitors. These compositions exert an excellent effect of preventing hair from graying as well as an effect of preventing hair removal and a hair nourishing effect. Furthermore, they are efficacious in preventing dandruff and itching of the scalp and softening the scalp, thereby totally ameliorating the scalp and hair conditions.

Description

 Description Composition for scalp hair

 The present invention relates to a composition for scalp hair which can be used as an anti-grey hair cosmetic or the like.

 Tyrosinase is a black pigment that plays a major role in absorbing excess light

An enzyme essential for the biosynthesis of "melanin" from tyrosine, and is deeply involved in the formation of spots and freckles caused by excessive exposure to sunlight and ultraviolet rays in areas such as the face and arms. Is known to be.

 In addition, tyrosinase is deeply involved in scalp darkening of the hair (blackening), and it has been shown that a decrease in tyrosinase activity in the scalp is one of the causes of hair graying. .

 Attempts have been made to promote the activity of tyrosinase to suppress the generation of gray hair or to improve it, and as a means for activating the production of melanin, Japanese Patent Application Laid-Open Nos. 5-78222 and 7-2 Japanese Patent Application Laid-Open No. H07-112129 describes the invention described in Japanese Patent Application Laid-Open Nos. 7-831 and 7-316020 and can exert both the effect of growing hair and the effect of preventing gray hair. The inventions described in JP-A-78-718 and JP-A-7-126129 are proposed. Due to the excellent tyrosinase activity promoting effect, blackening of gray hair can also be expected according to the invention capable of promoting the activity of tyrosinase. However, in the tyrosinase activity promoting effects of these inventions, in particular, there is a problem with persistence, for example, such an effect that the generation of gray hair can be visually suppressed or it can be clearly recognized that white hair has been improved. Has not yet been obtained.

Also, in the invention having both the hair-growth effect and the gray-hair preventing effect, the removal of gray hair makes it less noticeable, and only an effect comparable to that expected for blackening of the white hair is obtained. However, at the moment, it is not necessarily effective for improving gray hair It was a terrible thing.

 An object of the present invention is to provide a scalp / head hair composition which can exhibit an anti-grey-hair effect beyond the already proposed invention by combining a tyrosinase activity promoter as a key component and various elements. To provide. In addition, the composition for scalp and hair has an anti-greyness effect, a hair loss preventing effect and a hair nourishing effect on the scalp, and also a dandruff and power yumi prevention effect on the scalp and a softening effect, thereby improving the scalp and hair. The goal was to be able to comprehensively improve the condition. Disclosure of the invention

 The present inventor has set forth: (a) one or more tyrosinase activity promoters as essential components; (b) one or more of a penetration enhancer and Z or a blood flow enhancer; c) one or more hair follicle activators, or (d) one or more of five hair reductase inhibitors, in combination with each other or alone, containing the composition for scalp and hair. It has been found that the above problem can be solved by using the component. Hereinafter, such a composition for scalp hair of the present invention is also referred to as the present composition.

 In the present invention, a scalp hair composition is a composition capable of improving the condition of the scalp or hair in some way by externally applying the composition to the scalp or hair. means. Specifically, the improvement of the scalp and hair's proneness is, as described above, the effect of preventing scalp hair loss and hair growth, as well as the effect of preventing scalp dandruff and power blemishes and softening effect. It also means suppressing gray hair. An anti-grey-hair cosmetic having a main effect of inhibiting gray hair is one of the most suitably envisaged product embodiments in the present composition.

 A plant extract that may be contained in the present composition can be obtained from a desired plant material by an ordinary solvent extraction method.

 That is, a desired plant extract can be obtained by subjecting the plant material to freshness or, if necessary, drying and then subjecting it to solvent extraction as it is or after grinding. At this time, the solvent used can be selected from those generally used when extracting plant components from plants, and is not particularly limited.

For example, hot water or water; methanol, ethanol, isopropyl alcohol, n Lower alcohols such as butyl alcohol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrates of these alcohols; and hydrocarbon solvents such as n-hexane and toluene. However, it is preferable to use a lower alcohol such as methanol ethanol as an extraction solvent. When these lower alcohols are used as the extraction solvent, the resulting extract can be directly incorporated into the composition for scalp and hair of the present invention.However, the extraction solvent is once distilled off and dried if necessary. It is also possible to mix.

 In the present composition, a commercially available plant extract to be used can be used as a component. BEST MODE FOR CARRYING OUT THE INVENTION

 Hereinafter, embodiments of the present invention will be described.

 I. About the essential ingredients of this composition

 (a) Tyrosinase activity promoter

 The tyrosinase activity promoter is an essential component in all aspects of the present composition.

 The tyrosinase activity promoter that can be included in the present composition is a component that has an effect of promoting tyrosinase activity and is recognized as safe enough to be incorporated into an external composition. There is no particular limitation.

More specifically, for example, Sansho (scientific name: Zanthoxylum piperi tumCL.) DC). Power Yura ぺ (alias: no ヽ⁰ Lameria-Laeviga), Kayu rapet ヽ Scientific name: Parameria laev igata): Guaco misto (scientific name) : Mykania Glomerata), Pinguia (Pinguica 学 Scientific name: Arctostaphylos Pugens) ヽ Aritaso ゥ (Epazota ゝ Scientific name: Che Lord odium Arabrosioides), Sahote (Zapote, Scientific name: Poterium Zapote) or Axcopa que Extracts of such plants can be used as a tyrosinase activity promoter as a component of the present composition.

The salamander extract is an extract from salamander (Zanthoxylu m piperi tuma.) DC) belonging to the genus Citrus genus Citrus, and the fruit (peel), flowers, leaves, and trees of this plant Skin or the like can be used as a raw material for this extract. In particular, it is preferable to use a salmon extract using fruit (peel) as a raw material as a component of the present composition.

 Sansho extract is also commercially available. For example, Harvest's Sansho extract (Koei Kogyo), Huarco Rex Sansha (Ichimaru Fuarcos), Sansho II extract (Maruzen Pharmaceutical), etc. Can be contained.

 The power yurabe extract is an extract from a power plant of the Indonesian family belonging to the genus Parameria belonging to the genus Paramecia, which is an extract from the power plant Yurabe (also known as: Parameria 'Raebiga, Kayu rapet, scientific name: Parameria laevi gata). It is possible to use leaves, stems, flowers, bark, seeds or fruits of this plant, or even whole plants as raw materials.

 Guacomist extract is an extract from Guaco mist (Guanomist, scientific name: Mykania Glomerata), a Brazilian medicinal plant belonging to the genus Asteraceae, which belongs to the genus Asteraceae. The leaves, stems, flowers, bark, seeds or fruits, Furthermore, whole plants can be used as raw materials.

 The Pingui power extract is an extract from the medicinal plant Pinguica (Pinguica, scientific name: Arctostaphylos Pugens) belonging to the genus Urushi, belonging to the family Ledgeaceae. The leaves, stems, flowers, bark, seeds or fruits of this plant In addition, whole plants can be used as raw materials.

 The extract of Aritaso メ キ シ コ is an extract from the medicinal plant belonging to the genus Akaza, belonging to the genus Akaza (Epazota, scientific name: Chenopodi um Ambrosi oi des), and its leaves, stems, flowers, bark, seeds Alternatively, fruits, or even whole plants, can be used as raw materials.

Zapote extract is an extract from the medicinal plant belonging to the genus Poterium, Zapote (Za P0te, scientific name: Poterium Zapote). The leaves, stems, flowers, bark, seeds or fruits of this plant, and even plants Whole grass can be used as a raw material. Agguscopaque extract is an extract from Axcopaque (Gautheria Acuminata), a medicinal medicinal plant belonging to the genus Singulariaceae, which belongs to the genus Lingidae. The leaves, stems, flowers, bark, seeds or seeds of this plant are Fruits and even whole plants can be used as raw materials. The amount of the tyrosinase activity promoter as described above in the present composition should be appropriately selected according to the dosage form and product form of the present composition, and is not particularly limited. However, it is preferably 0.001 to 10.0% by weight, and particularly preferably 0.0005 to 5.0% by weight, based on the whole composition. If the amount of the tyrosinase activity promoter is less than 0.0001% by weight based on the whole composition, the desired effect of preventing gray hair is not sufficiently exhibited, and if it exceeds 10.0% by weight, Formulation problems may occur.

 In addition, the content of the plant extract (not limited to the tyrosinase activity promoter) in the present composition is expressed in terms of% by weight as a dried product or a liquid extract after removing the extraction solvent, unless otherwise specified.

 (b) penetration enhancer and Z or blood flow enhancer

 The penetration enhancer that can be included in the composition promotes penetration of other essential components of the composition, such as tyrosinase activity enhancer, into the skin, and as long as there is no safety problem as a component of the external preparation However, it should not be particularly limited, and its mechanism of action should not be questioned. In addition, the penetration enhancer can be used alone in the present composition, or can be used in combination of two or more.

 Specific examples of such a penetration enhancer include, for example, aminoxide, sodium dodecyl sulfate, and hydrogenated castor oil ethylene oxide (40 mol) adduct. Among these penetration enhancers, aminoxide is exemplified. It is preferred to select and incorporate into the composition.

 Aminoxide is not particularly limited, but may be, for example, a compound represented by the general formula (II)

R ¹ R ² R ³ NO (II) (wherein R ^ R ² and R ³ may be the same or different, and represent, for example, a linear or branched alkyl group having 1 to 25 carbon atoms. . ]

Examples thereof include, for example, dimethyllaurylamine oxide, stearyl dimethylamine oxide, and the like. It is particularly preferable that dimethylamine oxide represented by the following formula (I) be selected and contained in the present composition. . C¾ (CH ₂ ) CH ₃

CH ₃ (CH ₂ ) CHCH ₂ N → 0 (I)

CH, dimethylamoxide (hereinafter abbreviated as dimethylamoxide (I)) represented by the above formula (I) can be usually produced according to a known method for producing aminoxide. If one example is shown, it can be manufactured generally according to the following steps.

H-1 ₂ 0

 Dimethylamine oxide (I)

 Ethanol

The dimethylamine oxide (I) thus produced can be usually contained in the present composition through a purification step by a known purification method such as recrystallization, etc. The amount to be blended should be appropriately selected according to the specific dosage form and form of the present composition, and is not particularly limited. It is preferably 20.0% by weight, and particularly preferably 0.05 to 5.0% by weight. If the blending amount of the penetration enhancer is less than 0.001% by weight based on the whole composition, it is difficult to exert a sufficient penetration promoting effect of the tyrosinase activity enhancer and the like, and the amount is 20.0% by weight. Over the formulation Problems and skin irritation may occur.

 The blood flow enhancer that can be contained in the present composition is not particularly limited, as long as it is applied to the skin, blood flow is promoted, and there is no safety problem as a component of the external preparation. The mechanism of action should not be questioned. The blood flow enhancer can be used alone in the composition, but can also be used in combination of two or more.

 Specific examples of the blood flow promoting agent include nicotinic acid and its derivatives (in the present application, these are defined as nicotinic acids), minoxidil and its derivatives and analogs thereof (in the present application, these are referred to as nicotinic acid and derivatives thereof). Minoxidil), sempuri extract, cepharanthin, vitamin E and its derivatives (in the present application, these are defined as vitamin Es), 7-oryzanol, alkoxycarbonyl pyridine n-oxide, chloride chloride, acetylcholine And derivatives thereof (in the present application, these are defined as acetylcholines) and the like, which are blended as a blood flow promoter in general hair cosmetics such as hair restorer. Of these blood flow enhancers, it is preferable to select nicotinic acids, minoxidils, simplicity extract, bimin E and Z or a-oryzanol, and mix them in the present composition.

 Examples of the nicotinic acid derivative include benzyl nicotinate, tocopherol nicotinate, 5-butoxyshethyl nicotinate, amide nicotinate and the like.

 These nicotinic acids are currently commercially available and can be produced by a known production method.

 Minoxidil has a peripheral vasodilatory effect and has been used for the treatment of intractable hypertension, but since its hairy side effect was recognized as a side effect, it has been used as a topical topical agent. Yes (U.S. Pat. Nos. 4,139,619 and 4,596,812), whose chemical name is 6— (1-piperidyl) —2,4-pyrimidinediamine—3-oxide. is there.

Examples of the minoxidil derivative include a salt of minoxidil, and examples of the analog include an conjugate of minoxidil. These minoxidils are currently commercially available and can be produced by a known production method.

 The assembly extract is an extract containing the bitter glycoside of the gentian family (Swertia japoni ca akino) (the main component is swertiamarin. In the present invention, this extract is also included in the extract. It is a blood flow enhancer that is said to promote blood flow by expanding the capillaries of the skin.

 Sempuli extract is currently commercially available [Havex Sempuli Extract (Koei Kogyo), Sempuli Extract A (Alps Pharmaceutical), Sempuli Extract Liquid (Maruzen Pharmaceutical), etc.], and by known methods. Can be obtained by extraction.

 Examples of the biminamine E derivative include tocopherol acetate and tocopherol nicotinate.

 These vitamin Es are currently commercially available and can be produced by a known production method.

 ??? Oryzanol is contained in the seed coat of rice (Oryza sat iva L. (Gramineae)), and is mainly composed of a fureric acid ester of triterpene alcohol, and has an effect of promoting blood flow in capillaries. is there.

 7-Oryzanol is currently commercially available and can be obtained by known methods.

 The amount of the blood flow enhancer in the composition is preferably 0.01 to 5.0% by weight, and more preferably 0.01 to 2.0% by weight based on the total amount of the composition. Is particularly preferred. If the amount of the blood flow promoting agent is less than 0.01% by weight based on the total amount of the composition, it is difficult to exhibit a sufficient blood flow promoting effect and realize a synergistic gray hair preventing effect. If the content is more than 5.0% by weight, a problem may occur from the viewpoint of safety, such as skin irritation.

 Thus, by combining and combining the tyrosinase activity promoter with the penetration enhancer and / or the blood flow enhancer, the prevention or suppression of the generation of gray hair is superior to the case where the tyrosinase activity promoter is blended alone. The present composition having an effect is provided.

(c) Hair follicle activator The hair follicle activator that can be contained in the present composition exerts a hair nourishing effect (a hair loss suppressing effect, a hair growth promoting effect, an anti-dandruff / power-stain prevention effect, etc.) by activating the hair follicles of human hair. As long as there is no safety problem as a component of the external preparation, there is no particular limitation, and the mechanism of action should not be questioned. The hair follicle activator can be used alone in the composition, but can be used in combination of two or more.

The hair follicle activator, specifically, for example, nicotinic acid Ami de, vitamin B _e include, Piochin, pantothenic acid, cepharanthine, mononitroguayacol acids, 6-benzyl § amino purine, diisopropylamine di chloroacetic acid, Hinokichio And pentadecanoic acid monoglyceride.

 It is also conceivable that the hair follicle activator overlaps with the blood flow enhancer described above. In such a case, the agent of the present invention is used as an agent of any concept that can be contained in the present composition. (Of course, the present composition in such an embodiment is also an invention within the technical scope of the present invention).

 The content of the hair follicle activator of the present composition is preferably from 0.01 to 5.0% by weight, preferably from 0.01 to 2.0% by weight, based on the total amount of the composition. It is especially preferred. If the amount of the hair follicle activator is less than 0.001% by weight based on the total amount of the composition, the desired effect of preventing hair loss and hair growth, as well as the effect of preventing dandruff and scalp on the scalp, is synergistic. It is also difficult to achieve a typical gray hair prevention effect, and if it exceeds 5.0% by weight, it may be inconvenient in terms of formulation and the scalp tends to cause discomfort.

 In this way, by combining the tyrosinase activity promoter and the hair follicle activator into the present composition, more excellent gray hair generation can be obtained than when the tyrosinase activity promoter is contained alone. The present composition having a preventive or inhibitory effect of the present invention is provided. Further, the present composition is provided which has a hair-growth effect as well as a gray-hair suppression effect.

 (d) 5 Hi reductase inhibitors

The 5-hair reductase inhibitor that can be contained in the present composition exerts the effect of preventing hair loss by inhibiting the action of 5-reductase in human hair follicles, and is a safety problem as a component of an external preparation. As long as there is no particular limitation, no particular limitation is imposed on the mechanism of action. Also, 5—reductase inhibitors While it is possible for the composition to be used alone, it may also be used in combination of two or more.

Examples of the 5-reductase inhibitor include, for example, assenja extract, Achicolia (scientific name: Taraxacam of ficinales) extract, yervaluiza extract, yichii (Taxus cuspidata) extract, and inchinazu (Coronopus didymus). (Smith) extract, Clinch extract, Wolo (scientific name: Borassus fla vel l iffera) extract, Fennel (Foeniculum vulgare Mi Her (Umbel li ferae) extract, Usbenaoi (Malva sylvestrl s) L.) Extract, Age extract, Ortiganigura extract, Onji extract, Power extract, Kakochiya extract, Cuttlefish (Ageratum conyzoides L) extract, Kanokoso extract, Guarana extract, Power noredosan (Cardo santo, Scientific name: Argeraone mexicana) extract, Canso "ゥ extract, Catalpa ovata extract, Calendula power (Calendula) arvensis) extract, Calendula off icinal is extract, Oxmanthus fragr ans var. aurant icus extract, scallop (Schizonepeta tenui fol ia) extract, squirrel extract, geranium Siebold et Zuccarini (Geraniaceae) extract, Cuachalalate (scientific name: Juliana ana adtri ngens) extract, Kusanoo (Chel idonium majus subsp. Asiat icum) extract, Kumaseba extract (Swartzia polyphyl la) extract , Burdock extract, Korean oil, honey locust (Gledi tsia (Gledi tschia) japonica) extract, Psycho extract, Sanshishi extract, Peony extract, Shazenshi extract, Jang Kang, Scientific name: Stercul ia foetida) extract, Japanese fir (Dichroa febri fuga) extract, Sedro (Cedrela odorata L.) extract, Cedron extract, Senso ゥ(Rubia c ordifol ia var. Mimj ista) extract, Senso extract, Soybean extract, Daio extract, Downtrath (Daun traws, Scientific name: Liteseapdorifera Val) extract, Chanca pidra, Scientific name: Phyllanth Niruri L.) extract, clove extract, nigaki (Picrasma quassioides) extract, areca (Areca catechu L.) extract, Machiko (Matico, scientific name: Piper angusl ifolum) extract, Yakumo somaha extract bicolor Turcz.) extract, koninin extract, Regulo (Reglo, scientific name: Abelmoschus ffloschatus) extract, rosin, ivy extract, Altea (A lt aea off i cinal is L. (Malvaceae)) Extract, Yoti extract, Aloe extract, Lycium chinense extract, Artemisia extract, Rice (Oryza sat iva) extract, Mankeishi extract, Mannenrou (Rosmarinus off icinal is) extract, Kosaiho extract, Cystis scoparius extract, Gentian (Gent iana scabra var. Buergeri) extract, Tanjin extract, Hefia (Lufia cyl indrica M. Roeraen (Cue urbi taceae)) extract, Kikyoyo (Platycodon grandi florum) extract, pine extract, kujin extract, safflower extract, barberry extract, eucalyptus extract, mokku extract, gossip extract, cinnamon extract, hop extract Extract, chrysanthemum extract, senega extract, senki yu extract, katsuko extract, button (Paeonia suffruticosa Andrews (Poeonia montan Sims) (Paeoniaceae)) extract, Maikai power extract, saffron extract , Di O © extracts, Pepami Ntooiru, Kashuu extract, Japanese angelica root extract, a plant-derived component such as Gurichirure Chin acids;

 In addition, 5α-reductase inhibitors such as estrone, estradiol, oxendrone, finasteride and the like can be widely used.

 Here, each of the above-mentioned plant-derived components will be briefly described.

 Asenyaku (Asenyaku) extract is obtained by extracting water from the leaves and shoots of Uncaria gambir Roxburgh (Rubiaceae) with water, and then extracting it from the dried liquid (Asenyaku) with an ethanol solution or the like. Extract.

 Atticola is a plant belonging to the family Asteraceae and the genus Dandelion.

 It is known that the first leaf of yew contains al power-loid taxine and flavonoid sciadopi tysin.

 Butterfly is a young bud or fruit of the Japanese sagebrush (Artemisia capi l laris). A fennel extract is an extract obtained by extracting fennel fruit with water, ethanol and the like.

 Usenaiaoi is also known as Zeniaoi, and the extract can be obtained by extracting the flowers and or leaves thereof with water, ethanol, or the like.

Eiji (fruitful) extract is an extract obtained by extracting water, ethanol, or the like from the fruit of wild rose (Rosa mul tif lora Thungerg) or other closely related plants (Rosaceae). Onji (Enshi) is the root of human finfish (Polygala tenui fol ia), whisker (Polygal a japonica) and the like.

 Asagotica (summer hay) is the spike after the flower of the turtle (Prunel la vulgaris subsp. Asiatica).

 Katsuko Thistle is native to tropical America, has a peculiar aroma of whole plants, and is medicated as a private medicine in various places, and its extract is used for sublimation, diuresis, eye drops, and the like. Kanokoso extract is an extract obtained from the roots and rhizomes of Kanokoso (Valeriana fauriei Briquest) and Z or other closely related plants (Valerianaceae), usually by extraction with water.

 Guarana extract is an extract of Paul linia cupana Kunth seeds. Caldosanto is a plant belonging to the genus Poppyceae and the genus Azamigeshi.

 The extract of licorice can be produced by extracting the root of licorice (Glycyrrhiza uralensis Fisher, Glycyrrhiza g labra L.) and / or its congener (Leguminosae) with water and Z or ethanol.

 Catalpa extract can be obtained mainly by solvent extraction of catalpa fruit and or bark.

 Gay mussel extract is a solvent extract of the whole plant of Schi zonepeta tenuifol ia.

 Gengosi extract is a solvent extract of morning glory (Pharbi tis nil) seeds. Geno ginger extract is an extract obtained mainly by extracting an aerial part of geno ginger with an ethanol solution or the like.

 Kusanoo extract is usually a solvent extract of the whole plant.

 Burdock (burdock) extract is a solvent extract of burdock (Arctium lappa) fruit.

 Coriander oil is an essential oil obtained from the fruits of Coriander (Coriandrum sativum L.).

 The honey locust extract is mainly a solvent extract of honey locust fruit and Z or seed.

Psycho (Saiko) extract is a solvent for roots such as Mishima saiko (Bupleurum falcatum) It is an extract.

 Sanshin extract is a solvent extract of the fruits of gardenia (Gardenia jasminoides var. Grandi flora).

 Peony extract is an extract obtained by solvent extraction from roots of Paeonia (Paeonia lactif lora Pal las (Paeonia albi flora P; al las var. Trichocarpa Bunge)) or its closely related plant (Paeoniaceae) © It is.

 Shazenshi extract is a solvent extract of seeds such as planta asiatica.

 Daio extract is a solvent extract of roots such as Xining Daihuang (Rheum palmatum), Sichuan Daihuang (Rheum tanguticum), Yunnan Daihuang (Rheum off icinale).

 The extract of clover (clove) is a solvent extract obtained by drying buds of crab (Syzygium aromat icum Merri l l et Perr y (Eugenia caryophyl lata Thungerg) (Myrtaceae)), but using ethanol or the like.

 Areca extract is a solvent extract of areca fruit and Z or seeds (Acacia: areca).

 The extract of Yakmo-so (mother grass) is a solvent extract of the whole plant of swordfish (Leonurus sibiri cus).

 A yamahagi extract is a solvent extract of yamahagi leaves and grape or stem.

 The kuinin extract is an extract obtained by extracting the seed of the wheat (Coix lacryma-jobi L. var.ma-yuen Stapf (Gramineae)) from the seed coat with an extraction solvent such as water or ethanol. .

 Rosin is a solid resin obtained by removing the essential oil from the secretion of Pinus plants (eg, Pinus densif lora) and black pine (Pinus thiinbergii). The ivy extract is a solvent for the roots and stems of G. nanking, G. hirsutum, G. arboreum, and G. Herbaceum, for example, G. nanking. It is an extract.

Altea extract is derived from roots and leaves or leaves of the piloa mallow (Al thaea off icinal is L. (Malvaceae)), containing water, ethanol, propylene glycol and 1% urea. It is an extract obtained by extraction with an extraction solvent such as an ethanol-containing solution.

 Youti (Yotei) extract is a solvent extract of the roots of Rumex japonicus Hout t.

 Aloe extract: ① Aloe ferox Mi ler, or a hybrid of this with Aloe africana Mi ler or Aloe spicata Baker (Li liaceae), and some are Aloe barbadens is Mi ler (Aloe vera) or Extracts obtained by extracting leaves or leaf sap of Kidoe aloe (Aloe arborescens Miller) and also a variety of Kidachiaroe (Li 1 iaceae) with an extraction solvent such as water or ethanol; Aloe barbadens is Mil ler (Aloe vera L.) or Kidachi aloe (Aloe arborescens Mil ler), and the sap obtained from the leaves of the varieties of Kidachi aloe (Li Liaceae) is obtained after removing the aloin. It is an extract obtained by extracting or dissolving the obtained powder with water, ethanol or the like.

 Wolfberry extract is a solvent extract of the roots, fruits or leaves of wolfberry.

 The extract of Artemisia princeps Pampanini, Artemisia mongol ia Fischer or Artemisia montana Pampanini (Composi tae) is extracted from leaves of Artemisia montana Pampanini (Composi tae). It is.

 The mansilium extract is a solvent extract of the fruit of Egg (Vitex rotundifolia L. fil.).

 Mannenwax (Rosemari I) extract is extracted from leaves and / or flowers of Mannenwax with an extraction solvent such as water, ethanol or ethanol containing 1% urea. Extracts obtained by the extraction, or (3) powdered leaves of Mannenwax, (2) essential oil obtained by steam distillation of fresh leaves, stem tips, and flowers of Mannenwax.

 Kossaiho (bone crushing) extract can be obtained with a solvent extract of rhizomes, such as Hakamauraboshi (Drynaria fortunei), Drynaria sinica, and Ograsedonda (Agraomorpha coronans).

 Enishida extract is a solvent extract of the technical leaves of Enishida.

Gentian extract is a solvent extract of gentian rhizomes and roots (Ryutan). Tanjin extract is a solvent extract of the roots of Salvia mi lti orrhi za. The extract of luffa is: (1) an extract obtained by extracting the aerial part of luffa with an extraction solvent such as water and ethanol; and (2) after removing methanol eluate from the water-extracted extract of the whole plant of luffa. , A solution obtained by dissolving the extract extracted with bushnole in a mixture of ethanol and water, ⑧ a sample obtained by cutting off the stem of a hemp and collecting the water that has flowed out (hejima water), ④ a powder of the fruit of a hematoma And so on.

 Kikyoyou extract is a solvent extract of the root of Kikyo.

 The pine extract is an extract obtained by extracting the cone of Pinus sylvestris (Pinaceae) with an extraction solvent such as water, propylene glycol, and ethanol containing 1% urea.

 The extract of kujin (bitter ginseng) is obtained as a solvent extract of the root of Clara (Sophora angust ifol ia).

 The safflower extract is obtained by extracting the flower of safflower (Carthamus t inctorius L. (Composi tae)) as it is, or removing most of the yellow pigment, and pressing it into a plate to extract anhydrous ethanol, ethanol solution, etc. An extract obtained by extraction with a solvent, and (2) an extract obtained by extracting the whole plant of safflower with an extraction solvent such as an ethanol solution. Barberry extract is a plant belonging to the genus Berberis, such as barberry (B. thunbergi i), hebinoboraz (B. sieboldi i), and Hironohebinoboraz (B. amurensis var. Japonica) It is an extract obtained by extraction with an extraction solvent or the like such as a stem (including berberine).

 Eucalyptus extract is extracted from the leaves of Eucalyptus (Eucalyptus globulus L) or other closely related plants (Myrtaceae) using water, ethanol, or other extraction solvents, and ② The leaves of Eucalyptus or other closely related plants (Myrtaceae) O essential oil obtained by steam distillation

 The extract of mokudtsu (Kidori) is a solvent extraction of xylem such as Akebia quinata, A. trifol iata, A. quinata var. Polyphyl la, etc. 0

Gossip (cow knee) extract is a solvent extract of roots such as Achyranthes fauriei and A. bid entata. The tea extract is (1) an extract obtained by extracting from the leaves of the tree (Thea sinensis L (Theaceae)) (green tea) with an extraction solvent such as water and ethanol. (2) The defatted seeds of the tree ③ Extracts obtained by extracting with water from water, ③ Fatty oil obtained from the seeds of cypress, Thea sinens is L. (Theaceae).

 A hop extract is an extract obtained by extracting hop (Humulus lupulus (Moraceae)) female ears with an extraction solvent such as water or ethanol.

 The chrysanthemum extract is a plant belonging to the genus Chrysanthemum, for example, chrysanthemum (boaleale), oak (C. indicum). martschallii), etc., and is obtained by extraction with an extraction solvent for each part of the plant body.

 The Senega extract is an extract obtained by extracting a plant belonging to the genus Polygala, for example, roots of Senega (Polygala senega), Hirono senega (Polygala senega var. Latifolia), etc. with an extraction solvent.

 The extract of Senkiyu is obtained by extracting from the rhizome of (Cnidium officinale akino (Umbel lifer ae)) with an extraction solvent such as water and ethanol, and (2) extracting from the rhizome of Senkiyu with water. It is a liquid obtained by steam distillation from an extract.

 The katsukon extract is an extract obtained by extracting the pericut root of kudzu (Pueraria lobata Ohwi (Leg inosae)) with an extraction solvent such as anhydrous ethanol.

 The button extract is an extract obtained by extracting the rhizome of a button (Paeonia suffruticosa Andrews (Poeonia montan Sims) (Paeoniaceae)) with an extraction solvent such as an ethanol solution. Such button extracts include extracts of buttonpi (peony), the root bark of buttons.

 The Maikai strength extract is an extract obtained by extracting the herb of Maikai (Rosa maikai (R. rugosa var. Plena)) or button rose (Rosa odorata (Andr.) Sweet) with an extraction solvent. .

 The saffron extract is an extract obtained by extracting the stigma of saffron (Crocus sativus L. (Iridaceae)) with an extraction solvent such as water.

The dio extract was prepared from acadia (Rehmaimia glutinosa Libschitz var. PT / JP00 092 ea Makino). Or an extract obtained from roots of other congener plants (Scrophulariaceae) with an extraction solvent such as water or ethanol.

 Peppermint oil is an essential oil obtained from the stems and leaves of peppermint (Mentha piperita L.) in the Labiatae family.

 Kashui (Head of Bird) extract is an extract obtained by extracting root nodules of Polygonum multiflorum with an extraction solvent.

 The extract of Touki (Toki) is an extract obtained by extracting the root of Touki (Angelica acuti lobaCLigusticum acutilobu m) with an extraction solvent.

 The content of the 5-hydroxylase inhibitor in the present composition is preferably from 0.001 to 10.0% by weight based on the total amount of the composition, and from 0.01 to 5.0% by weight. Particularly preferred is 0% by weight. (5) If the amount of the hair reductase inhibitor is less than 0.01% by weight based on the total amount of the composition, the desired hair loss preventing effect is exhibited, and it is difficult to realize a synergistic white hair preventing effect. If it exceeds 10.0% by weight, it may be inconvenient for the preparation.

 Thus, by combining the tyrosinase activity promoter and the 5a-reductase inhibitor in the present composition, it is superior to the case where the tyrosinase activity promoter is contained alone. The present composition having an effect of preventing or inhibiting the development of gray hair is provided. In addition, the present composition is provided which has an effect of preventing hair loss as well as an effect of inhibiting gray hair.

 As described above, (a) one or two or more tyrosinase activity promoters are essential components, and (b) one or two or more penetration enhancers and Z or blood flow promoters, (C) one or more hair follicle activators, or (d) one or more 5-heale reductase inhibitors, in combination with each other or alone, as components of the composition for scalp hair. By doing so, it is possible to provide a scalp hair composition (the present composition) capable of synergistically exhibiting an excellent white hair preventing effect and also exhibiting various hair restoring effects.

E. Specific form of the composition

This composition contains general base ingredients and medicinal ingredients that can be blended with ordinary external compositions (including hair compositions) according to the formulation type and form of the specific composition. Type and It can be blended as long as the desired effect is not impaired in the form. Specifically, diluents, surfactants, higher alcohols, oils, humectants, thickeners, solvents, usability improvers, preservatives, antioxidants, sequestering agents, ultraviolet protection agents, powder components, Various drugs, coloring agents, fragrances, and the like can be appropriately selected and blended according to the desired dosage form and form.

 Examples of the diluent include water, ethanol, isopropyl alcohol, and glycols.

 Among the surfactants, examples of the anionic surfactant include alkyl benzene sulfonate, polyoxyalkylene alkyl sulfate, alkyl sulfate ester, olefin sulfonate, alkyl phosphate, and polyoxyalkylene alkyl ether phosphorus. Acid salts, dialkyl sulfosuccinates, fatty acid salts and the like.

 Examples of nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyglycerin fatty acid ester, and polyoxyethylene cured. Castor oil derivatives, fatty acid diethanolamide and the like.

 Examples of the cationic surfactant include a tertiary aliphatic amine salt, an alkyltrimethylammonium halide, a dialkyldimethylammonium halide, and the like.

 Examples of the amphoteric surfactant include amidbetaine type, imidazolinium betaine type, and sulfobetaine type amphoteric surfactants.

 Examples of higher alcohols include cetyl alcohol, stearyl alcohol, behenyl alcohol and the like.

 Examples of the oil component include higher fatty acids, solid paraffin, liquid paraffin, silicone oil, polymeric silicone and its derivatives, squalane, petrolatum, and ester oil.

Examples of the humectant include glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol and the like. You.

 Examples of the thickener include methylcellulose, hydroxyshethylcellulose, carrageenan, carboxymethylcellulose, and cationized cellulose.

 Examples of the solvent include water, ethanol, isopropyl alcohol, benzyl alcohol and the like.

 Usability improvers include, for example, methylpolysiloxane, methylaminopropylsiloxane and the like.

 Examples of the preservative include benzoic acid, dehydroacetic acid, para-hydroxybenzoic acid ester (methyl para-oxybenzoate, butyl para-oxybenzoate, etc.), phenoxy ethanol and the like.

 Examples of the antioxidant include ascorbic acid and BHA.

 Examples of the sequestering agent include ethylenediaminetetraacetic acid (edetic acid), tripolyphosphate and the like.

 Examples of the ultraviolet ray protective agent include oxybenzone and butyl methoxy benzoyl methyl.

 Examples of the powder component include powder resins such as silica, nylon powder, and polyethylene powder.

 As the various drugs, drugs other than vitamins and plant extracts that can be used as essential components in the present invention can be used.

 Further, for example, anti-inflammatory agents, antibacterial agents, organic acids, and the like can also be incorporated in the present composition (these various agents can be used in combination as needed). Of course).

The dosage form of the composition may be any liquid, emulsion, ointment, or any other form that can be applied to the skin or scalp.Generally, lotions, creams, oils, gels, hair tonics, hair liquids, It can take the form of treatments, aerosol mousses, aerosol sprays and the like. In addition, the composition is applicable in various fields such as pharmaceuticals, quasi-drugs, and cosmetics. The present composition is, as described above, an anti-grey-hair cosmetic having a main effect of inhibiting gray hair is one of the most suitable product embodiments of the present composition.

 This composition is generally used by transdermal administration such as directly applying or spraying on the skin. The amount of the composition to be used should be appropriately determined according to individual differences such as age and degree of gray hair, and the dosage form and form. Example

 Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be interpreted in a limited manner. In addition, the blending amount in these examples and the like is% by weight based on the entire system in which the component is blended, unless otherwise specified.

Preparation of various plant extracts

 (Preparation of salamander extract)

 50 Og of the perilla skin was soaked in ethanol at room temperature for one week, and ethanol in this extract was distilled off to obtain 9.7 g of a perilla extract.

 In the test examples and formulation examples described below, this extract was used as “Sasan Extract J”.

 (Preparation of power yurabe extract)

 50 Og of the whole plant of Kurajube was immersed in ethanol at room temperature for 1 week, and the ethanol in this extract was distilled off to obtain 10.3 g of Kurayube extract.

 In the test examples and formulation examples described below, this extract was used as “Rikiyurabe extract”.

 (Preparation of guacomist extract)

 50 Og of whole guacomist plant was immersed in ethanol for 1 week at room temperature, and ethanol in this extract was distilled off to obtain 10.1 g of guacomist extract.

 In the test examples and formulation examples described below, this extract was used as “guacomist extract”.

 (Preparation of Pingui force extract)

The whole plant of Pingui's strength was immersed in 50 Og of ethanol at room temperature for 1 week. Ethanol was distilled off to obtain 9.3 g of Pingui power extract.

 In the test examples and formulation examples described below, this extract was used as “Pingy force extract”.

 [Preparation of Aritaso ゥ extract]

 A total of 50 Og of Arita soybean was immersed in ethanol at room temperature for 1 week, and ethanol in this extract was distilled off to obtain 9.3 g of Arisa soybean extract.

 In the test examples and formulation examples described below, this extract was used as “aritaso ゥ extract”.

 (Preparation of Zapote extract)

 50 Og of the whole plant of Zapote was immersed in ethanol for 1 week at room temperature, and ethanol in this extract was distilled off to obtain 9.3 g of Zapote extract.

 In the test examples and formulation examples described below, this extract was used as “Zapote extract”.

 (Preparation of Axcopaque extract)

 A total of 500 g of Axcopaque was immersed in ethanol at room temperature for one week, and ethanol in the extract was distilled off to obtain 9.3 g of an Axcopaque extract.

 In the test examples and formulation examples described below, this extract was used as “Axcopaque extract”.

 The other plant extracts used in this example, specifically, peanut extract, cashew extract, kanzo extract, quayaralarte extract, cilantro extract, janyank extract, toukiki extract, peony extract The extract, the peony extract, the jinxin extract, etc. were produced according to a conventional method for producing the extract.

Evaluation test method

 1. Investigation of the preventive or inhibitory effect of human hair growth on cumulative application (white hair prevention test)

 Test method>

As subjects, a total of 40 men and women between the ages of 40 and 60 with gray hair in each lotion were given twice a day (morning and night) for 4 consecutive months, on the left and right crowns using the half-head method. The hair on the right and left parietal parts is applied before and 4 months after the start of application. The number of white hairs per 100,000 hairs was counted, and the effect of preventing or suppressing the generation of white hairs was examined.

 The results were determined using the following criteria.

 <Judgment criteria>

 The number of gray hairs after application is less than the number of gray hairs before application

(Very effective) Less than 70% of subjects are 50% or more.

 + +: The number of gray hairs after application is smaller than the number of gray hairs before application

(Remarkable effect) 50% or more of the subjects were 70% or more and less than 80%.

 +: The number of gray hairs after application is compared to the number of gray hairs before application

(Effective) 80% or more and less than 90% of subjects are 50% or more.

 Sat: The number of white hairs after application is compared to the number of white hairs before application is started

(Somewhat effective) 50% or more of subjects are 90% or more and less than 100%.

 The number of gray hairs after application is less than the number of gray hairs before application

(Invalid) Less than 50% of subjects are 90% or more and less than 100%.

 2. Hair restoration effect test

 Test method>

 A tricogram test was also performed to examine the hair growth effect of the test article. The subject was a male, and in each of the comparative examples and examples, there were no subjects. The test period was 4 months, and during the sample application period, the samples were applied to the scalp twice a day, 2 to 4 mL each time. Immediately before the start of application and after the end of application for 4 months, 50 hairs were randomly removed from the crown of each subject, and the roots of the removed hairs were observed under a microscope. The follicle resting rate () was calculated. The percentage of increase / decrease in the rate of rest period before and after sample application was determined based on the following criteria.

 Judgment criteria>

 Remarkable effect Hair root telogen rate decreased by more than 30%

 Effective Hair root telogen rate decreased by more than 20%

 Weak effect Hair telogen rate decreased by more than 10%

No effect Reduction of hair root telogen rate is less than 10% or hair root telogen rate is increased.Evaluation of the hair restoration effect is effective when the number of subjects with “effective” or higher exceeds 50%. Others were invalidated.

 3. Hair loss prevention effect test

 <Test method>

 The change in the number of hair removal due to hair washing before and after use of the sample was used as an index. The subjects were male, and each group consisted of 10 persons in each of the comparative example and the example. The test period was six months, the first two months were the period of no sample application, and the last four months were the sample application period. During the test period, the hair was washed every other day to collect the hair loss, and one week was counted and the number of the end hairs was counted. The number of hair loss was evaluated using the number of hair loss per hair wash during the sample application period as an index, and the average value in the last week of the first semester and the average value of the last week in the second semester were compared. The results were judged according to the following criteria. The results were evaluated as valid when the percentage of subjects with a score of + or more was 50% or more, and invalid with respect to the others.

 <Judgment criteria>

 + +: The number of hair loss decreased by 70 or more, and a remarkable effect was recognized.

 +: The number of hair loss was reduced by 40 or more, and a considerable effect was recognized.

 Soil: The number of hair loss decreased by 10 or more, and a slight effect was recognized.

 1: The number of hair loss decreased by 9 or less or the number of hair loss increased, and no effect was observed.

 4. Dandruff and force Yumi prevention effect test

 Test method>

 In particular, men who complained of dandruff and force Yumi were examined, and in each of the comparative examples and examples, 10 dandruff and force Yumi after the test were investigated for each group, and the amount of protein in dandruff and the degree of force Yumi were determined. It was evaluated as an index. The application period of the sample was three months, during which time the hair was washed once a day with a shampoo containing no drug, and the sample was applied to the scalp twice a day, twice a day.

 At the end of the test, before washing the hair from the subject, dandruff was collected from the head using a suction device, and the amount of protein in the dandruff was measured. In addition, each subject was examined for scalp force Yumi, and the degree was evaluated according to the following criteria.

 <Judgment criteria>

3: Strong power Yumi is recognized. 2: Power Yumi is recognized.

 1: Some power Yumi is recognized.

 0: Power Yumi is not recognized.

Test example

 Hereinafter, the embodiments of the present composition are roughly classified into the following three types.For each embodiment, test articles corresponding to Examples and Comparative Examples are prepared, and an appropriate one of the above test methods is selected. The present invention was evaluated. In addition, prescription examples of each embodiment are listed as g in Examples.

 Embodiment A: An embodiment in which (a) a tyrosinase activity enhancer is combined with (b) a penetration enhancer and / or a blood flow enhancer.

 Embodiment B: Embodiment in which (a) tyrosinase activity promoter and (c) hair follicle activator are combined and combined

 Embodiment C: An embodiment in which (a) a tyrosinase activity promoter is combined with (d) a 5-reductase inhibitor

 I. Test Example of Aspect A

 As the lotion related to the present composition of embodiment A, the lotion having the formulation shown in Table A1 was prepared and subjected to the above-mentioned whitening prevention test.

 Each lotion was manufactured according to the following manufacturing method.

 <Production method>

 Dimethylamine oxide (I), nicotinic acid, polyvinylpyrrolidone Z-vinyl acetate copolymer, preservative and fragrance were added to ethanol and uniformly dissolved. To this, the previously dissolved aqueous phase (salmon extract, purified water, silicone derivative and glycerin) was added and dissolved.

The results of the gray hair prevention test are shown in Table A1 together with the above criteria. Table A1 Numbers in the table are in% by weight

第 A 1表の結果より、 チロシナ一ゼ活性促進剤として用いたサンショウ抽出物 のみ配合した比較ローション Aは、 白髪の発生の予防または抑制効果を有するも のの、 サンショウ抽出物および浸透促進剤のジメチルアミンォキシド （ I ) を組 み合わせて配合した本発明ローション A、 サンシさゥ抽出物、 ジメチルアミ ンォ キシド （ I ) および血流促進剤のニコチン酸を組み合わせて配合した本発明口一 シヨン B、 または、 サンショウ抽出物およびニコチン酸を組み合わせて配合した 本発明口一ション Cの方が、 比較口一ション Aよりも優れた白髪の発生の予防ま たは抑制効果を有することが明らかになった。 また、 サンショウ抽出物を配合せ ず、 ジメチルアミンォキシド （ I ) およびニコチン酸のみを組み合わせて配合し ても、 白髪の発生の予防または抑制効果が認められないことも明らかになった (比較ローション B) 。

From the results in Table A1, Comparative Lotion A containing only the ginger extract used as a tyrosinase activity enhancer has the effect of preventing or inhibiting the development of gray hair, but the ginger extract and the permeation enhancement A of the present invention comprising a combination of the lotion A of the present invention, a combination of the extract of Sanshisa, dimethylamine oxide (I), and nicotinic acid, a blood flow promoter, which are combined with the dimethylamine oxide (I) of the present invention. Preparation C of the present invention, which is a combination of Shillon B or a combination of salmon extract and nicotinic acid, is superior to Comparative Preparation A in preventing gray hair development. It has also been found to have an inhibitory effect. In addition, it was also found that even if dimethylamine oxide (I) and nicotinic acid alone were used in combination without using the salmon extract, no preventive or inhibitory effect on the generation of gray hair was observed (comparison) Lotion B).

 That is, in the lotions A, B, and C of the present invention, in which a permeation enhancer and / or a blood flow enhancer are combined with a salmon extract, which is a tyrosinase activity enhancer, the synergistic prevention or suppression of gray hair development It was clear that the effect was noticeable. This indicates that the desired effect can be obtained only by using a small amount of salamander extract and a penetration enhancer and Z or a blood flow enhancer.

 Hereinafter, other formulation examples of the composition of the embodiment A will be described as examples.

 In addition, the present composition of embodiment A of these examples was also examined for the effect of preventing or inhibiting the development of human gray hair, and the results of "effective" to "extremely effective" were found in all examples. was gotten.

 [Example A l] Hair tonic

 (Blend components) Blend amount (Weight

(1) Polyoxyethylene hydrogenated castor oil (40 E.O.) 2.0

 (2) Salmon extract 1 0

 (3) 95% ethanol 0 0

 (4) Tocopherol nicotinate 0 1

 (5) Dimethylamoxide (I) 80

 (6) Fragrance suitable

 (7) Remaining purified water

 <Manufacturing method>

 After (1), (4), (5) and (6) were added to (3) and dissolved by stirring, (2) was added to (7) and the resulting solution was stirred and dissolved to obtain a hair tonic.

 [Example A2] Hair tonic

 (Blend components) Blend amount (Weight

(1) Glycerin 2.0 (2) L—Menthol 0.1

 (3) Salmon extract 0.1

 (4) 95% ethanol 60, 0

 (5) Dimethylaminooxide (I) 4.0

 (6) Minoxidil 1.0

 (7) Appropriate amount of fragrance

 (8) Remaining purified water

 <Production method>

 Add (1), (2), (5), (6), and (7) to (4), stir and dissolve, then add (3) to (8) and stir and dissolve to add hair tonic. Obtained.

 [Example A3] Hair tonic

 (Blend components) Blend amount (Weight

(1) Polyethylene glycol 200 2.0

 (2) L-menthol 0.2

 (3) Salmon extract 0.0 1

(4) 95% ethanol 50.0

 (5) Dimethylaminooxide (I) 10.0

 (6) Benzyl nicotinate 0.05

(7) Appropriate amount of fragrance

 (8) Remaining purified water

 Production method>

 Add (1), (2), (5), (6), and (7) to (4), stir and dissolve, then add (3) to (8) and stir and dissolve to add hair tonic. Obtained.

 [Example A4] Hair liquid

 (Ingredients) Amount (wt%)

(1) Polyoxypropyl butyl ether (40 P.O.) 15.0

 (2) Polyoxypropyl butyl ether phosphoric acid (40 P.O.) 15.0

 (3) Salmon extract 0.001

(4) 1,3-butylene glycol 5.0 (5) 95% ethanol 50.0

 (6) Dimethylamine oxide (I) 10.0

 (7) Tocoprol acetate 0.1

 (8) Suitable amount of fragrance

 (9) Dye appropriate amount

 (10) Appropriate amount of edetic acid

 (11) Residual amount of purified water

 <Production method>

 Add (1) (2) (4) (6) (7) (8) to (5) and dissolve with stirring, then add (3) (9) (10) to (11) and dissolve with stirring The obtained hair liquid was obtained.

 [Example A5] Skull treatment

 (Ingredients) Amount (wt%)

(1) 1,3-propylene glycol 0.5

 (2) Tetra-2-ethylhexanoate pentaerythritol 1.2

 (3) 95% ethanol 60.0

 (4) Salmon extract 1.0

 (5) Sempuli extract 1.0

 (6) Dimethylamine oxide (I) 0.5

 (7) Appropriate amount of fragrance

 (8) Dimethyl ether ZLPG (95-5) Residual amount

 Production method>

 (1), (2), (4), (5), (6), and (7) were added to (3), and the mixture was stirred and dissolved to prepare a stock solution. The can was filled with the stock solution, and after mounting the valve, (8) was filled to obtain a scalp treatment.

 [Example A6] Hair cream

 (Ingredients) Amount (wt%) <A phase>

(1) Liquid paraffin 5.0 (2) Cetostearyl alcohol 5.5

 (3) Vaseline 5.5

 (4) Glyceryl monostearate 3.0

 (5) Polyoxyethylene (20 mole addition)

 — 2-octyldodecyl ether 3.0

 (6) Dimethylaminooxide (I) 0.01 (7) Tocoprol acetate 0.05 (8) Propylparaben 0.3

 (9) Fragrance 0.05 <8 phase>

 (10) Salmon extract 0.5

 (11) Glycerin 7.0

 (12) Dipropylene glycol 20.0

 (13) Polyethylene glycol 4 0 0 0 5.0

 (14) Hexamenoic acid phosphate reader 0.0 5

(15) Remaining purified water

 <Production method>

 (1) to (9) were mixed and dissolved by heating to prepare phase A. Separately, (10) to (15) were mixed and dissolved by heating to prepare phase B. Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.

 [Example A7] Haziel

 (Ingredients) Amount (wt%)

(1) Carboxyvinyl polymer 0.7

 (2) Polyvinylpyrrolidone 2.0

 (3) Glycerin 4.0

 (4) Salmon extract 0.0 1

(5) Sodium hydroxide

 (6) Ethanol 20.0

(7) Polyoxyethylene octyl dodecyl ether (8) Dimethylaminooxide (I) 2.0

 (9) 7—Oryzanol 2.0

 (10) Appropriate amount of fragrance

 (11) Edetoic acid

 (12) Remaining purified water

 Manufacturing method>

 (1) was dispersed in (3) and a part of purified water. The other components were dissolved in the remaining purified water, and this was added to the above-mentioned dispersion while stirring, to obtain Haziel.

 [Example A8] Haziel

 (Ingredients) Amount (wt%)

(1) Carboxyvinyl polymer 0, 5

 (2) Glycerin 50.0

 (3) Amount of sodium hydroxide

 (4) Ethanol 10.0

 (5) Salmon extract 0.001

(6) Polyoxyethylene octyl dodecyl ether

 (7) Dimethylammonoxide (I) 1.0

 (8) Nicotinic acid 2.0

 (9) Fragrance suitable

 (10) Edetate Suitable M.

 (11) Residual amount of purified water

 <Manufacturing method>

 (1) was dispersed in (2) and a part of purified water. The other components were dissolved in the remaining purified water, and this was added to the above-mentioned dispersion while stirring, to obtain Haziel.

 [Example A 9] Hair spray

 (Stock solution formulation) Amount (weight)

(1) Acryl resin alkanolamine salt (507.0

 (2) Cetyl alcohol 0.1

(3) Silicone oil (methylphenylpolysiloxane) 0.3 (4) Ethanol 90.0

 (5) Salmon extract 0.1

 (6) Appropriate amount of fragrance

 (7) Nicotinic acid / 3-butoxystil 0.5

 (8) Dimethylamine oxide (I) 1.0

 (Filling prescription)

 (9) Stock solution 50.0

 (10) Dimethyl ether 45.0

 (11) LPG 5.0

 <Production method>

 (1), (2) and (3) were uniformly emulsified with a homomixer. This was added to (4), (5) to (8), and added to the stirred and dissolved solution to prepare a stock solution (9). The undiluted solution (9) was filled in a can, and after fitting the valve, (10) and (11) were filled to obtain a hair spray.

 E. Test Example of Aspect B

 1. Gray hair prevention test

Table B1 (Example) and Table B2 (Comparative Example) show the results of the above-described white hair prevention test for the present composition of Embodiment B, together with the formulation of the test article used.

Table B 1

 Example

 Ingredients

 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Salmon extract 0.001 10.0 0.01 7.0 0.05 2.0 0.1 3.0 0.2 0.5 0.0001 0.3

Potato extract 丄 .0 Guacomist extract 0.2 Nicotinic acid amide 0.3 ― ― I ― ― ― ― ― ― ― 0.2 0.2 Vitamin B ₆ 0.1

Pyotin 0.2

Pantotenylethyl

 1.0 0.2

 X Tell

Seven Phalantin 0.003

 Nonitroguaiacol----0.5-------------------------------------------------------------------------------------------------------------------

 6 Benzylaminopurine ― ― ― ― ― ― ― 2.0 ― ― ― 1 ― Disopropylamine 1 1 1 1 1 1 1 ―

Chloroacetic acid 5.0 1 1 1 1 1 Hinokitiol 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1-Monoglyceride

Jib mouth pyrene glycol 1.0 1.0 1.0 1.0 1.0 1.0 1. 1. U 1. U 1. 8 U 丄. 丄. Υ 丄. U 丄. U Hardened castor oil ethylene

 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Oxide (40 mol) adduct

Succinic acid apt right apt IL apt apt apt apt apt right apt apt apt q M fragrance and dye apt apt apt apt apt apt apt apt apt apt

95% ethanol 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 Purified water Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining White hair prevention effect + + + + + + + + + + + + + + + + + + + + + + + + + + +

Table B 2

 Comparative example

 Ingredients

 10 11 12 13 14 Salmon extract 1.0

Power Yurabe extract.

Guacomist Extract 1.0

Nicotinic acid amide 1.0

Vitamin B '0.5

Piotin 0.5

Pantotenylethyl

Ether 1.0

Cepharanthin 0.01

Mononitroguaiacol 0.5

Mononitroguaiacol

 1.0

Sodium

 6-Benzylaminopurine 1.0

Gysoprovirmin

Dichloroacetic acid 1.0

Hinokitiol 0.5 pentadecanoic acid

 4.0 Monoglycerides

Dipropylene glycol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Hydrogenated castor oil ethylene

 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Oxide (40 mol) adduct

 3 Citric acid suitable suitable suitable amount suitable amount suitable amount suitable amount suitable amount appropriate amount suitable suitable amount appropriate amount suitable summer suitable amount suitable amount appropriate amount appropriate summer suitable amount appropriate amount appropriate appropriate amount S Yoshiri

95% ethanol 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 Purified water Remaining Remaining — Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Reducing effect of white hair + + +

From the results shown in Tables B1 and B2, Comparative Examples B1 to B3 containing only the respective tyrosinase activity promoters exhibited the effect of preventing or inhibiting the development of gray hair, but the activation of hair follicles It was revealed that Examples B1 to B11 in which the agent was blended exhibited a more excellent effect of preventing or suppressing gray hair than Comparative Example B1. In addition, it was revealed that even if the hair follicle activator alone was added without the tyrosinase activity promoter, the effect of preventing or preventing the generation of gray hair was not observed (Comparative Examples B4 to B14). ) o

 That is, in the lotion (Examples B1 to B14) of the present composition in which a hair follicle activator is combined with a tyrosinase activity promoter, a synergistic effect of the generation or prevention of gray hair is remarkably recognized. It became clear. This indicates that the use of a small amount of a tyrosinase activity promoter and a hair follicle activator can exert a sufficient gray hair development or preventive effect.

 2. Hair restoration effect test and hair loss prevention effect test

The results of the hair growth effect test and the hair loss prevention effect test described above for the present composition of Embodiment B (Examples B 1 to B 14 ■ Comparative Examples B 1 to B 14) are shown in Table B3 (hair growth Effect test) and Table B4 (hair loss prevention effect test).

Table B 3

 Reduced hair root telogen rate (¾) Hair restoration effect group

Notable effect Effective effect Weak effect No effect Evaluation Example 1 20 40 20 20 Effective Example 2 30 30 30 10 Effective Example 3 30 30 30 10 Effective Example 4 40 40 20 0 Effective Example 5 10 60 10 20 Effective Example 6 30 50 20 0 Valid Example 7 20 40 20 20 Valid Example 8 20 50 0 30 Valid Example 9 10 40 40 10 Valid Example 10 20 50 20 10 Valid Example 11 10 40 40 10 Valid Example 12 20 40 30 10 Valid Example 13 10 60 10 20 Valid Example 14 30 30 30 10 Valid Comparative Example 1 10 20 30 40 Invalid Comparative Example 2 0 0 20 80 Invalid Comparative Example 3 0 0 40 60 Invalid Comparative Example 4 0 0 10 90 Invalid Comparative example 5 0 0 30 70 Invalid Comparative example 6 0 30 10 60 Invalid Comparative example 7 10 10 20 60 Invalid Comparative example 8 0 0 20 80 Invalid Comparative example 9 0 20 20 60 Invalid Comparative example 10 0 0 10 90 Invalid Comparative example 11 0 20 0 80 Invalid Comparative example 12 0 10 10 80 Invalid Comparative example 13 0 0 30 70 Invalid Comparative example 14 0 0 40 60 Invalid Table B 4

 Reduced number of hair loss (¾) Group '1 Hair loss prevention effect

 + + + Evaluation of soil-Example 1 20 50 10 20 Effective Example 2 10 50 20 20 Effective Example 3 20 50 o 30 Effective Example 4 40 40 20 0 Effective

5Example 5 10 60 in 20 Effective Lonely Example 6 20 60 10 10 Effective Example 7 30 10 10 Effective Example 8 10 30 10 Effective Example 9 10 40 40 10 Effective Lonely Example 10 10 30 10 Effective Example 11 30 30 20 20 Effective Example 12 30 40 20 10 Effective Lonely Example 13 10 60 10 20 Effective Example 14 10 50 30 10 Effective Comparative Example 1 10 30 10 50 Invalid Comparative Example 2 0 10 30 60 Invalid Comparative Example 3 0 0 30 70 Invalid Comparative example 4 0 0 10 90 Invalid Comparative example 5 '0 10 30 60 Invalid Comparative example 6 0 30 0 70 Invalid Comparative example 7 0 10 20 70 Invalid Comparative example 8 0 0 20 80 Invalid Comparative example 9 10 0 30 60 Invalid Comparative example 10 0 0 10 90 Invalid Comparative example 11 0 20 10 70 Invalid Comparative example 12 0 10 10 80 Invalid Comparative example 13 0 0 30 70 Invalid Comparative example 14 0 0 30 70 Invalid

According to the results shown in Tables B3 and B4, the lotion (Example B1B14) of the present composition, in which a hair follicle activator was combined with a tyrosinase activity promoter, showed excellent hair growth. It was clear that the effect and the effect of preventing hair loss were recognized.

 3. Dandruff and force Yumi prevention effect test

 Table B5 shows the results of the above-mentioned dandruff / force wrinkle prevention effect test on the composition of Embodiment B (Example B1B14 / Comparative Example B1B14). Table B5

 God

 Group average dandruff (mg) (average score)

 ¾Example 1 g 2 0.6

 ¾Example 2 5.6 0.5

 荬 Example 3 6 73 0.6

 Example 4 6.0 0.8

 Lonely example 5 6.99 0.5

 Lonely example 6 8.11 0.8

 Example 7 7.59 0.7

 Example 8 7.55 0.7

 Example 9 7.89 0.9

 Example 10 6.18 0.5

 Example U 7.3 0.5

 Example 12 6.42 0.5

 Example 13 6.5 0.5

 Example 14 6.83 0.6

 Comparative Example 1 17.33 1.4

 Comparative Example 2 19.91 1.7

 Comparative Example 3 18.25 1.6

 Comparative Example 4 18.06 1.7

 Comparative Example 5 18.47 1.4

 Comparative Example 6 22.08 1.7

 Comparative Example 7 20.11 2.0

 Comparative Example 8 19.54 1.8

 Comparative Example 9 18.83 1.9

 Comparative Example 10 16.99 1.6

 Comparative Example 11 17.87 1.6

 Comparative Example 12 19.89 1.7

 Comparative Example 13 18.03 1.9

 Comparative Example 14 19.11 1.7

Based on the results shown in Table B5, the combination of tyrosinase activity promoter and hair follicle activator It was clear that the lotion of the composition (Examples B1 to B14), which had been blended together, exhibited an excellent dandruff / semi-prevention effect.

 Hereinafter, other formulation examples of the composition of the embodiment B will be described as examples.

 In addition, the present composition of embodiment B of these examples was also examined for the effect of preventing or suppressing the occurrence of gray hair in humans. The result was obtained.

 [Example B15] Hair lotion

 (Blend components) Blend amount (Weight

(1) 95% ethanol 550

 (2) Salmon extract 5 0

 (3) Nicotinic acid amide 0 5

 (4) Hinokitiol 0 2

 (5) 1,3-butylene glycol 1 5

 (6) Polyoxyethylene hydrogenated castor oil (60 E.O.) 10

 (7) Succinic acid

 (8) Appropriate amount of fragrance

 (9) Dye appropriate amount

 (10) Residual purified water

 Manufacturing method>

 (2) was dissolved in (1), and then (3), (4), (5), (6), and (8) were added and dissolved therein. Further, a solution obtained by dissolving (7) and (9) in (10) was added to the above-mentioned dissolved material, followed by stirring to obtain a transparent liquid lotion.

 [Example B16] Hair lotion

 (Blend components) Blend amount (Weight

 (1) 95% ethanol 75.0

 (2) Salmon extract 0 0 3

(3) Pantothenyl ethyl ether 50

 (4) Cepharanthin 0 0 5

(5) Dipropylene glycol 10 (6) P〇E (24 mol) · Ρ〇Ρ (13 mol)

 Decyl tetradecyl ether 0.5

 (7) Lactic acid

 (8) Sodium lactate appropriate amount

 (9) Appropriate amount of fragrance

 (10) Dye appropriate amount

 (11) Remaining purified water

 <Production method>

 (2) was dissolved in (1), and then (3) to (6) and (9) were added and dissolved therein. Further, a solution obtained by dissolving (7), (8) and (10) in (11) was added to the above-mentioned dissolved material, followed by stirring to obtain a transparent liquid lotion.

 [Example Β 17] Hair lotion

 (Ingredients) Amount (wt%)

(1) 95% ethanol 60.0

 (2) Pingui force extract 1 0.0

 (3) Sodium mononitroguaycol 1.0

(4) Vitamin Β ₆ 0.5

 (5) 6-aminobenzirpurine 0.5

 (6) diisopropylamine dichloroacetic acid 0.05

 (7) Polyethylene glycol 400 0 0.5

 (8) Polyoxyethylene hydrogenated castor oil (20 Ε.Ο.) 1.0

 (9) Phosphoric acid

 (10) Appropriate amount of fragrance

 (11) Dye appropriate amount

 (12) Remaining purified water

 Manufacturing method>

(2) was dissolved in (1), and then (3) to (8) and (10) were added and dissolved therein. Further, a solution obtained by dissolving (9) and (11) in (12) was added to the above-mentioned dissolved material, followed by stirring to obtain a transparent liquid lotion. [Example B18] Hair lotion

 (Blend components) Blend amount (Weight

(1) 95% ethanol 550

 (2) Salmon extract 20

 (3) Axcopaque extract 10

 (4) Nicotinamide 0 5

 (5) Hinokitiol 0 2

 (6) 1, 3—butylene glycol 1 5

 (7) Polyoxyethylene hydrogenated castor oil (60 E.O.) 10

 (8) Succinic acid

 (9) Appropriate amount of fragrance

 (10) Dye appropriate amount

 (11) Remaining purified water

 Manufacturing method>

 (2) and (3) were dissolved in (1), and then (4) to (7) were added and dissolved therein. Further, a solution obtained by dissolving (8) and (10) in (11) was added to the above-mentioned dissolved material, followed by stirring to obtain a transparent liquid lotion.

 [Example B 19] Hair liquid

 (Ingredients) Ingredients: (wt%)

(1) Polyoxypropyl butyl ether (40 P.O.) 200

 (2) Polyoxypropyl butyl ether phosphoric acid (40 P.O.) 50

 (3) Potato extract 0 0 0 1

(4) Glycerin 10

 (5) 95% ethanol 55 0

 (6) Piotin 0 5

 (7) Fragrance

 (8) Dye appropriate amount

 (9) Lactic acid

(10) Residual purified water <Production method>

 Add (1) (2) (4) (6) (7) to (5) and dissolve with stirring, then add (3) (8) (9) to (10) and dissolve with stirring. In addition, I got a hair liquid.

 [Example B20] Scalp treatment

 (Ingredients) Amount (weight

(1) 1,3-propylene glycol 1 5

 (2) Erythritol 1 0

 (3) 95% ethanol 600

 (4) Zapote extract 1 0

 (5) Penyu decanoic acid monoglyceride 0 6

 (6) Appropriate amount of fragrance

 (7) Remaining purified water

 (8) Dimethyl ether qs

 <Production method>

 (1), (2), (4), (5), and (6) were added to (3), and the mixture was stirred and dissolved. Then, (7) was added thereto to prepare a stock solution. The can was filled with the stock solution, the valve was attached, and then (8) was filled to obtain a scalp treatment.

 [Example B21] Hair cream

 (Ingredients) Amount (wt%) <A phase>

 (1) Liquid paraffin 8.0

 (2) Cetostearyl alcohol 5.5

 (3) Vaseline 5.5

 (4) Glyceryl monostearate 3.0

 (5) Sorbitan monooleate 3.0

 (6) Hinokitiol 0.5

 (7) Tocoprole acetate 1.0

(8) Butylparaben 0.2 (9) Fragrance 0.3

 <Phase B>

 (10) Pingui force extract 1.0

 (11) Glycerin 5.0

 (12) Dipropylene glycol 20.0

 (13) Polyethylene glycol 150 0 0 5.0

 (14) Hexamedium sodium phosphate 0.05

(15) Remaining purified water

 <Production method>

 (1) to (9) were mixed and dissolved by heating to prepare phase A. Separately, (10) to (15) were mixed and dissolved by heating to prepare phase B. Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.

 [Example B 22] Haziel

 (Ingredients) Amount (wt%)

(1) Carboxyvinyl polymer 0.45

(2) Xanthan gum 0 2

 (3) Polyvinyl pyrrolidone 30

 () Sorbitol 20

 (5) Axcopaque extract 0 0 0 1

(6) Sodium hydroxide suitable M

 (7) Ethanol 15.0

 (8) POE octyldodecyl ether

(9) vitamin B ₆ 2. 0

 (10) Perfume Nao

 (11) Edetic acid

 (12) Purified water

 Manufacturing method>

(1) to (5) (11) were dissolved in (12). Further, (8) to (10) are dissolved in (7), and this dissolved substance is added to the above parts while stirring, and then (6) Was added to the mixture to increase the viscosity, and a hair oil was obtained.

 [Example B23] Hair spray

 (Ingredients) Amount (wt%) (stock solution formulation)

 (1) Acryl resin Alminol amine salt 10.0

 (2) SEUNO NORD 0.1

 (3) Dodecamethylpolysiloxane 0.5

 (4) Ethanol stock solution residue

(5) Salmon extract 0.0 1

(6) Fragrance suitable M

 (7) Pantothenyl ethyl ether 0.01

 (Filling prescription)

 (8) Stock solution 6 0.0

 (9) Dimethyl ether 35.0

 (10) LPG 5.0

 Manufacturing method>

 (1) to (3) and (5) to (7) were dissolved in (4) to prepare a stock solution. The undiluted solution (8) was filled in a can, and after mounting the valve, (9) and (10) were filled to obtain a hair spray.

m. Test example of mode c

 Lotions related to the present composition of embodiment C were prepared as shown in Tables C1 and C2 and subjected to the above-mentioned gray hair prevention test.

 Each lotion was manufactured according to the following manufacturing method.

 Production method>

 The aqueous extract was prepared by adding the plant extract and succinic acid to the purified water and uniformly dissolving the same. The other raw materials were dissolved in ethanol, and this was added to the aqueous extract and further dissolved. .

The results of the gray hair prevention test are shown in Tables C1 and C2, using the above criteria. Table C1

 Comparative example

 Ingredients

 10 11 12 13 14 15 Salmon extract 0.001

Power Yurabe extract 0.0001

Guacomist extract 0.5

Peanut extract 0.2

Power Extract 0.5

Kanzo extract 0.1

Quaylarara extract 0.1

Koreanda extract 0.3

Jancan extract 1.0

Touki extract 0.2

Peony extract 0.1

Kuddin extract 0.01

 /? — Glycyrrhetinic acid 2.0

Jib mouth pyrene glycol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 hydrogenated castor oil ethylene

 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Oxide (40 mol) adduct

Succinic acid S

95% 夕 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 Purified water Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Preventing whitening

Suppression effect + +

* Means that the hair has been actively removed

Table C 2

 Example

 Ingredients

 1 2 3 4 5 6 7 8 9 10 11 12 Sansho extract 1.0-0.1--0.05--0.01--Force jube extract-0.001--0.01--0.3--0.5 0.5 Guacomist extract--0.5 ― 1 0.001 1 1 1 0.002 ― ― 0.02 Peanut extract 1 0.5 ― ― 1 1 1 ― 1 ― 1 1 Cashew extract ― 1 2.0 ― 1 1 ― 1 1 1 ― 1 Cannabis extract 1 1 1 1 1 1 ― ― ― Quantitative extract '0.5 0.3 Coriander extract ― ― ― 2.0 ― ―― ― ― ―

Jyankang extract ― 11 ― ― ― 0.1 ― ― 11 ― Touki extract 11 ― 11 ― 0.3 ― ― ― 0.2 Peony extract ― ― ― ― 1 ― ― 1 0.01 11 ― Whale extract 4.0 ― ― 1--1 1-1-0.0005-1-Glycyrrhetinic acid 3.0

Jib mouth pyrene glycol 1.0 _; 1.0 1-0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 hydrogenated castor oil ethylene

 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 刁 Kinoto (4 υMoslepa sword D

Konodic acid liquor Optimum amount Optimum Optimistic ri¾i ¾ ¾ ί¾ ¾ ¾ ¾ ¾¾ ¾¾ ¾¾ ¾¾ 適

95% ethanol 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 55.0 Purified water Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining Preventing or generating white hair

Suppression effect + + + + + + + + + + + + + + + + + +

Based on the results shown in Tables C1 and C2, Comparative Examples C1 to C3 containing only the respective tyrosinase activity promoters exhibited the effect of preventing or inhibiting the development of gray hair, but showed that 5a-reductase was used. It became clear that Examples C1 to C12 in which the inhibitor was blended exhibited more excellent gray hair prevention or suppression effects than Comparative Examples C1 to C3. In addition, it was also found that the prevention or prevention of the generation of gray hair was not observed when only the 5-hi reductase inhibitor was used without using the tyrosinase activity promoter (Comparative Example C4). ~ (15).

 That is, a lotion of the present composition comprising a combination of a tyrosinase activity promoter and a 5α-reductase inhibitor (Examples C1 to (: 12) shows a synergistic effect of white hair development or prevention). This indicates that the use of a small amount of a tyrosinase activity promoter and a 5-hi reductase inhibitor can exert a sufficient gray hair development or prevention effect. It shows.

 Hereinafter, other formulation examples of the composition of the embodiment C will be described as examples.

 In addition, the effect of preventing or suppressing the generation of gray hair in humans was also examined for the present composition of embodiment C of these examples. The result was obtained.

 [Example C13] Hair tonic

 (Blend components) Blend amount (Weight

(1) Polyoxyethylene hydrogenated castor oil (40Ε.0) 2.0

 (2) Salmon extract 0.1

 (3) 95% ethanol 70.0

 (4) Peanut extract 0.1

 (5) Appropriate amount of fragrance

 (6) Remaining purified water

 Manufacturing method>

 (1) (4) (5) was added to (3), and the mixture was stirred and dissolved. Then, (2) was added to (6), and the mixture was stirred and dissolved. The mixture was added to the ethanol phase, and further stirred. Got a tonic.

(Example C14) Hair tonic (Ingredient) Ingredient (weight

 (1) Glycerin 2.0

 (2) L—Menthol 0.1

 (3) Salmon extract 0.0 1

 (4) 95% ethanol 60.0

 (5) Kanzo extract 0.1

 (6) Appropriate amount of fragrance

 (7) Remaining purified water

 <Production method>

 After adding (1), (2), (5) and (6) to (4) and dissolving with stirring, add (3) to (7) and dissolve with stirring, and then add to the ethanol phase and further stir. And got a hair tonic.

 [Example C15] Hair tonic

 (Ingredients) Amount (wt%)

(1) Polyethylene glycol 2.0

 (2) L—Menthol 0.2

 (3) Salmon extract 0.0 1

 (4) 95% ethanol 50.0

 (5) Quayalarate extract 0.1

 (6) Appropriate amount of fragrance

 (7) Remaining purified water

 Production method>

 After adding (1), (2), (5) and (6) to (4) and dissolving with stirring, add (3) to (7) and dissolve with stirring, and then add to the ethanol phase and further stir. And got a hair tonic.

 [Example C16] Hair liquid

 (Ingredients) Amount (weight)

(1) Polyoxypropyl butyl ether (40 P.O.) 15.0

(2) Polyoxypropyl butyl ether phosphoric acid (40 PO) 15.0 (3) Salmon extract 0.0 0 0 1 (4) 1,3-butylene glycol 5.0

 (5) 95% ethanol 50.0

 (6) Coriander extract 0.1

 (7) Appropriate amount of fragrance

 (8) Dye appropriate amount

 (9) edetic acid

 (10) Residual purified water

 Manufacturing method>

 Add (1), (2), (4), (6), and (7) to (5) and dissolve with stirring. Add (3), (8), and (9) to (10), and dissolve with stirring. In addition, I got a hair liquid.

 [Example C17] Skull treatment

 (Ingredients) Amount (wt%)

(1) 1,3-propylene glycol 0.5

 (2) Pentyl-2-ethyl hexanoate erythrit 1.2

 (3) 95% ethanol 60.0

 (4) Salmon extract 0.00 0 5

(5) Jancan extract 0.1

 (6) Appropriate amount of fragrance

 (7) Dimethyl ether ZLPG (95/5)

 Manufacturing method>

 (1), (2), (4), (5), and (6) were added to (3), and the mixture was stirred and dissolved to prepare a stock solution. The can was filled with the stock solution, the valve was fitted, and then (7) was filled to obtain a scalp treatment.

 [Example C18] Hair cream

 (Ingredients) Incorporation amount (weight kuhachi>

(1) Liquid paraffin 5.0 (2) Cetostearyl alcohol 55

 (3) Vaseline 5 5

 (4) Glyceryl monostearate 30

 (5) POE (20 mole addition) 1-year-old octyldodecyl ether 30

 (6) Chicken extract 0 0 1

(7) Tocoprol acetate 0 0 5

(8) Propylparaben 0 3

 (9) Fragrance 0 0 5

 <Phase B>

 (10) Salmon extract 0 0 0 2

(11) Glycerin 7 0

 (12) Dipropylene glycol 200

 (13) Polyethylene glycol 4 0 0 0 5 0

 (14) Hexametaphosphate Houda 0 0 0 5

(15) Purified water

 Manufacturing method>

(1) (9) were mixed, dissolved by heating, apart from the Re _t prepared Phase A was prepared mixed, heated and dissolved to B phase (10) (15). Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.

 [Example C19] Haziel

 (Ingredients) Amount (wt%)

(1) Ryboxoxyvinyl polymer 0.7

 (2) Polyvinyl pyrrolidone 2.0

 (3) Glycerin 4.0

 (4) Salmon extract 0 0 1

(5) Sodium hydroxide Μ summer

 (6) Ethanol 20.0

 (7) POE Octildo de Cilletel Mm

(9) Sanshin extract 2.0 (10) Appropriate amount of fragrance

 (11) Edetoic acid

 (12) Remaining purified water

 Manufacturing method>

 (1) and (3) were dispersed in a part of purified water. The other components were dissolved in the remaining purified water, and added to the above-mentioned dispersion with stirring to obtain Haziel.

 [Example C20] Haziel

 (Ingredients) Amount (wt%)

(1) Carboxyvinyl polymer 07

 (2) Glycerin 500

 (3) Suitable for sodium hydroxide

 (4) Ethanol 200

 (5) Salmon extract 0 00 1

(6) POE Octyldodecyl ether qs

 (7) Cuttlefish extract 2.0

 (8) Suitable amount of fragrance

 (10) Appropriate amount of edetic acid

 (11) Remaining purified water

 Manufacturing method>

 (1) and (2) were dispersed in a part of purified water. The other components were dissolved in the remaining purified water, and added to the above-mentioned dispersion with stirring to obtain Haziel.

 [Example C 21] Hair spray

 (Ingredients) Amount (wt%) (stock solution formulation)

 (1) Acrylic resin alkanolamine salt 7.0

 (2) Cetanol 0, 1

 (3) Silicone oil (methylphenylpolysiloxane) 0.3

 (4) Ethanol 90.0

(5) Salmon extract 0.0 1 (6) Appropriate amount of fragrance

 (7) Peony extract 0.0 1

 (Filling prescription)

 (8) Stock solution 50.0

 (9) Dimethyl ether 45.0

 (10) LPG 5.0

 Manufacturing method>

 (1), (2) and (3) were uniformly emulsified with a homomixer. This emulsion was added to the solution obtained by adding (5) to (7) to (4) and stirred and dissolved to prepare a stock solution (8). The can was filled with the stock solution (8), and after fitting the valve, (9) and (10) were filled to obtain a hair spray. Industrial applicability

 INDUSTRIAL APPLICABILITY As described above, the present invention provides a scalp hair composition that is extremely useful for preventing and preventing the occurrence of gray hair and that has excellent safety.

Claims

The scope of the claims 1. A scalp / hair composition containing a tyrosinase activity promoter. 2. The tyrosinase promoter is Sansho (scientific name: Zanthoxylum piperitum (L.) DC), Yurabe (alias: Parameria laevigata, Kayu rapet, scientific name: Parameria la evigata): Guaco misto (scientific name: Mykania Glomerata), Bing squid (Pinguica, scientific name: Arctostaphylos Pugens)> Aritasou (Epazota, academic name:. Che Sir odium Arabrosioides to), Zapote (Zapote, scientific name: Poterium Zapote) and Akusukonoヽ⁰ Beautique (Axcopaque, scientific name: Gaut eria Acuminata) The composition for scalp and hair according to claim 1, which is an extract of one or more plants selected from the group consisting of phylla.  3. The composition for scalp hair according to claim 1 or 2, wherein the content of the tyrosinase activity promoter is 0.0001 to 10.0% by weight based on the whole composition. . 4. The scalp hair composition according to any one of claims 1 to 3, comprising a penetration enhancer and Z or a blood flow enhancer.  5. The composition for scalp hair according to claim 4, wherein the penetration enhancer is an amine oxide.  6. Aminoxide has the formula (I) C (CH ₂ ) C¾ CH ₃ (CH ₂ ) _n CHCH ₂ N → 0 (1) The scalp hair composition according to claim 5, which is dimethylamine oxide represented by CH ,. 7. Blood flow enhancers include nicotinic acids, minoxidil, sempuri extract, cephalanthine, vitamin Es, 7-oryzanol, alkoxycarboryl pyridine N- The scalp hair according to any one of claims 4 to 6, which is one or two or more blood flow enhancers selected from the group consisting of oxides, chlorides, and acetylcholines. Composition.  8. The scalp hair composition according to any one of claims 1 to 7, comprising a hair follicle activator. 9. Hair follicle activating agent, nicotinic acid Ami de, vitamin B ₆ such, Piochin, pantothenic acid, cepharanthine, mononitroguayacol acids, 6-benzyl § amino purine, Jie isopropyl § Min-ji chloroacetic acid, hinokitiol and pen evening decane 9. The scalp hair composition according to claim 8, which is one or more hair follicle activators selected from the group consisting of acid monoglycerides.  10. The composition for scalp hair according to claim 8 or 9, wherein the content of the hair follicle activator is from 0.001 to 5.0% by weight based on the whole composition.  11. The scalp hair composition according to any one of claims 1 to 10, comprising a 11.5 α-reductase inhibitor. 12.5 α-reductase inhibitor is selected from the group consisting of estrone, estradiol, glycyrrhetinic acids, oxendrone, finasteride, asenyaku extract, achicoria (Acicolia. Scientific name: Taraxacam off icinales) extract, yervaliza extract, Yew (Taxus cuspidata) extract, Inchi nana (Coronopus didymus (L.) Smith) extract, Polo (Wolo, Scientific name: Borassus f lavel l iffera) extract, Squid (Foeniculum vulgare Mir ler (Umbel 1 if era) )) Extracts, Malva sylvestrls L.) extracts, Age extract, Ortiganigra extract, Onji extract, Power extract, Kakochiya extract, Katsukozami (Ageratura conyzoides) extract, Kanokoso Extract, Guarana extract, Cardo santo (scientific name: Argemone mexicana) extract, Kanzo extract, Catalpa (Catalpa ovata) extract, calendula arvensis extract, cinnamon (Osmanthus fragrans var. Auranticus extract, sycamore (Schizonepeta tenuifol ia) extract, kengoshi extract, genoceraberg (Geraini b (G eraniaceae) extract, Cuachalalate (scientific name: Juliana ana adstri ngens) extract, Kusanoo (Chel idonium majus subsp. Asiaticunu extract, bear Seva (Swartzia polyphyl la) extract, Gobishi extract, Burdock extract, Korean oil, honey bee (Gledi tsia (Gledi tsc ia) japonica) extract, Psycho extract, Sanshishi extract, Peony extract, Shazenshi extract Extract, Jang Kang (scientific name: Stercul ia foetida) extract, diojan (Dichroa febrifuga) extract, sedro (Cedrela odorata) extract, senso (RuMa cordifol ia var. M unj ista) extract, soybean Extract, Daio extract, Downtrath (Daun traws, Scientific name: LUseapdorifera Val) extract, Chang force pidra (Chanca pidra, Scientific name: Phyl lanthus Niruri L.) extract, Chile extract, Picrasma quassiides Extract, areca (Areca catechu L.) extract, Machiko (Matico, scientific name: Piper angusl if olum) extract, Yakumoso (Leonurus sibiricus) extract, Jamaha (Lespedeza bicolor Turcz.) Extract, okuinin extract, Reglo (scientific name: Abelmoschus moschatus) extract, rosin, ivy extract, Altea (Al thaea off icinal is L (Malvaceae)) extract, Youti extract , Aloe extract, wolfberry (Lycium chinense) extract, mugwort extract, rice (Oryza sativa) extract, mangeshishi extract, mannenrou (Rosmarinus off icinal is) extract, kossaiho extract, and bonito (Cytisus scoparius) ) Extract, Gentian (Gent iana scabra var. Buerge ri) extract, Tanjin extract, Luffa cyl indrica. Roemen (Cucurbi ta ceae) extract, Kikyo (Platycodon grandif lorum) extract, Pine extract , Kudin extract, safflower extract, barberry extract, eucalyptus extract, mokku extract, gossip extract, cherries extract, hop extract, chrysanthemum extract, senega extract, Cucumber extract, katsukon extract, Button (Paeonia suffrut icosa Andrews (Poeonia montane Sims) (Paeoniaceae)) extract, Maikai power extract, Saffron extract, Geo extract, Peppermint oil, Cashew extract and 12. The scalp hair composition according to claim 11, wherein the composition is one or more components selected from the group consisting of a corn extract.  13. The scalp hair composition according to any one of claims 1 to 12, which is used as an anti-grey-hair cosmetic.