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WO2001030407A1 - Procede de preparation d'hydrogels destines au traitement de brulures et de blessures - Google Patents

Procede de preparation d'hydrogels destines au traitement de brulures et de blessures Download PDF

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Publication number
WO2001030407A1
WO2001030407A1 PCT/IN1999/000068 IN9900068W WO0130407A1 WO 2001030407 A1 WO2001030407 A1 WO 2001030407A1 IN 9900068 W IN9900068 W IN 9900068W WO 0130407 A1 WO0130407 A1 WO 0130407A1
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WO
WIPO (PCT)
Prior art keywords
manufacture
burn
agar
treatment
hydrogel dressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN1999/000068
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English (en)
Inventor
Lalit Varshney
Advait Ajit Kumar Majmudar
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India Atomic Energy Department of
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India Atomic Energy Department of
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Filing date
Publication date
Application filed by India Atomic Energy Department of filed Critical India Atomic Energy Department of
Priority to AU21277/00A priority Critical patent/AU2127700A/en
Publication of WO2001030407A1 publication Critical patent/WO2001030407A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents

Definitions

  • This invention relates to process for manufacturing hydrogel dressings useful as dressing for burn and injuries.
  • This invention particularly relates to a process for manufacturing hydrogel dressings based on polyvinyl alcohol. 5
  • Hydrogeis have three dimensional network structure of polymer chains holding significant amount of water.
  • the water holding capacity of a hydrogel depends upon the basic polymer network structure, other ingredients and the 10 production process. In spite of their very high water content, these solid hydrogeis are not soluble in water.
  • Synthetic and natural polymers along with other chemical ingredients have been used for making hydrogeis. Synthetic polymers, however, form the main base 15 material in all these hydrogeis.
  • Polymers employed in manufacturing hydrogeis useful as burn dressings are mainly polyvinyl pyrrolidone, vinyl pyrrolidone, acrylamide, poly vinyl alcohol, polyethylene oxide, gelatin and agar-agar. Along with these polymers use of a 20 plasticizer such as silicone oil and polyethylene glycol have been reported in US Pat. 4871490 (1989). Viscosity modifiers or adhesion improvers like cyclodextrin have also been used [J P Appln.
  • hydrogel dressings such as thawing, freezing using different solvent systems as in US Pat 4663358; use of cross-linking agents such as formaldehyde, glutaraldehyde, methylene bis acrylamide, oxidising agents [Hirai T. et. al., J.Appli Polym. Sci, 46,1449,1992 & US Patent 5076265, 1991 ] and irradiation as in US Patent 4871490(1989) have been used as appropriate to the raw materials.
  • Some of the processes for making hydrogel dressings are multi stage like gel formation, cleaning, post dosing and sterilizing.
  • irradiation is a clean process and does not require toxic chemicals like cross-linkers, initiators etc. for forming hydrogel, thereby reducing the chances of undue toxicity in the final product.
  • Gamma radiation and electron beam are used for cross linking polymers in solid as well as in solution form and the technique is also used for sterilizing medical products.
  • some of the water molecules undergoes radiolytic decomposition forming free radicals like OH. H and e- aqueous.
  • These radicals mainly OH abstract hydrogen atom present on the PVA molecule to form reactive radical site on it. Two of such radical sites combine to form a cross-link.
  • cross-linked molecules form a three-dimensional network to form hydrogel.
  • Nature of the polymer, Cross-link density and network structure determines the hydrogel qualities.
  • the hydrogeis formed with different cross-linking density and network structure would have different characteristics with respect to its water absorption, tensile strength, elongation, distribution of pore sizes etc.
  • Presence of natural polymers like polysaccharides and proteins like gelatin could modify these characteristics of the network structure, changes in internal volume etc., over and above imparting strength to the hydrogel.
  • the presence of ionic groups on some of them, could significantly change the water absorption characteristics.
  • the level of acetyl groups in PVA also modifies characteristics of the hydrogel in terms of its transparency and strength which is related to basic network structure.
  • Hydrogel dressings are gaining widespread acceptance in recent times for burns and injury treatment. Different types of gels are either available in market abroad or under clinical trials. These Hydrogeis are based on different formulations and production processes.
  • Some known commercial hydrogeis dressings use multi layer/laminates (US Pat appln. 824564, 1997), foams dipped in gel like substance (Burn Free, USA), hydrogel (Geliperm, Switzerland), porous hydrogel and sheets (US Pat. 4663358, 1987), US Pat. 5076,265/19, 1991) gauze based hydrogel would dressing (US Pat. 5076,265, 1995) etc.
  • Some gels have antibiotics in the dressing (US pat. 4646730/19 1987).
  • Therapeutic Gell Dressing which is a clear, semi firm, cross-linked PVP/water gel, supported by an internal non-woven web and a polyethylene backing, whose active surface is protected by a removable polyethylene release film. It is packaged in a shallow tray inside a foil peel-open pouch, (see US Pat. 4646730(1987)].
  • Polish Patent Specification No. 128,392 describes a method for manufacturing dressings including drugs, involving applying a layer of a hydrophilic gel obtained by the radiation polymerization of synthetic polymers, such as polyacrylamide, polyvinylpyrolidone, polyvinyl alcohol, polyethylene oxide, their monomers or their mixtures on the mechanical base of a dressing after or before impregnating it with a drug, thereafter the dressing is dried and sterilized.
  • synthetic polymers such as polyacrylamide, polyvinylpyrolidone, polyvinyl alcohol, polyethylene oxide, their monomers or their mixtures
  • PV hydrogel which comprises being obtained by irradiating a polyvinyl alcohol aqueous solution containing a polymer selected from the group consisting of polyvinyl pyrrolidone, a methyl vinyl ether-maleic anhydride copolymer and an isobutylene-maleic anhydride copolymer, with ionizing radiations, a process for preparing the PVA hydrogel, a hydrogel laminate using the PVA hydrogel, a process for preparing the hydrogel laminate, and a hydrogel wound-dressing material using the PVA hydrogel.
  • the main object of the present invention is to develop a process for manufacturing hydrogel dressings for burn or other skin injuries, satisfying the above functional requirements.
  • Another object of the invention is to obtain a hydrogel having stable, mechanically strong, physical structure, so that it can be used directly as a dressing for burn healing.
  • Another object of the invention is to develop one step irradiation process for formation of hydrogel and sterilization with a view to make it into simple, cheap burn dressing.
  • the production process should eliminate post irradiation treatment, like washing, annealing, use of secondary support, sterilization etc.
  • the process should fit into the normal commercial irradiation plant operation cycle give more that 95% yield and should be adaptable for automated large scale production of hydrogeis. To make the hydrogel dressing economical, the process should be simple and use minimum and locally available ingredients.
  • Our approach is to develop a one stage irradiation process based on the excellent biocompatible synthetic polymer -PVA, supplementing it, if necessary, with different natural polymers, avoiding other extraneous chemicals, or mechanical supports to obtain preferably 3-5 mm thick plain hydrogel dressing satisfying all functional requirements.
  • step (iii) subjecting the said aqueous solution in the sealed trays obtained at the end of step (ii), to irradiation at room temperature to form the sterile ready to use hydrogel dressing.
  • polyvinyl alcohol used has average molecular wt. in the range 27,000 - 1 ,25,000 and its acetate content is less than 18% by wt. but preferably it is 6 - 12%.
  • the components of the aqueous solution is generally :
  • polyvinyl alcohol 5-15% by wt.
  • agar-agar and other natural polymers and their derivatives 0.5-5% by wt. of which the said other natural polymer and/or its derivative form 0 - 4.5% by wt. of the aqueous solution.
  • Polyvinyl alcohol 5-15% (w/w) Average Molecular weight : 25000 - 125000
  • Acetate contents 0-12%, desirable 6-12%
  • Natural polymers 0.4 to 5% (w/w), from gelatin, agar-agar, carageenan, sodium alginate, sodium carboxymethyl cellulose, gum acacia etc. of high purity or pharmaceutical grade.
  • Containers Disposable trays made up of PET (polyethylene terephthalate, HDPE (high density polyethylene) and PVC (polyvinyl chloride) of medical or food grade quality.
  • PET polyethylene terephthalate
  • HDPE high density polyethylene
  • PVC polyvinyl chloride
  • Irradiation Gamma or electron beam irradiation can be carried out for gel production.
  • the hydrogel manufacturing process of the present invention is as follows :
  • PVA and natural polymers are dissolved in a suitable glass container.
  • the solution is poured in plastic trays and cooled to room temperature for setting.
  • the trays are sealed in polyethylene or laminate pouches made of PET/aluminium/PE. Number of such sealed trays are placed in card board carton and are irradiated by either gamma irradiation or electron beam at 25-60 kGy dose. Due to inherent production parameters the filled and sealed trays need not be irradiated immediately and this factor helps to accommodate delays (about one week) between production and irradiation. This factor is important to enable manufactures who use contract radiation sterilization services.
  • Polyvinyl alcohol chosen has any average molecular wt. covering the entire range 35,000 - 146,000 ; OR in the range 80,000 - 125,000 OR 90,000 - 100,000, OR 30,000 - 45,000, preferably 80,000 - 125,000.
  • the polyvinyl alcohol chosen of different molecular wt. has acetate content up to 18% by wt. OR 6 - 12% by wt. OR 8 -12% by wt. OR 0 - 1 % by wt.
  • the radiation dose applied to the said aqueous solution to form the hydrogel is 25 - 60 kGy OR 35 - 50 kGy OR 25 - 30 kGy OR 30 kGy.
  • Hydrogeis of this process of invention made with components such as in following quantities are found to have good water absorption and gel qualities. a) Polyvinyl alcohol 14% by wt., agar-agar 3% by wt. of the aqueous solution and no other natural polymers and/or their derivatives are used.
  • Hydrogeis of any desired thickness or shape are made by this process of invention but those in the 3-5 mm thickness are preferred.
  • Appropriate plastic mould can be selected for required gel dimensions.
  • Polyvinyl alcohol solution in water, containing natural polymers can be cross-linked using radiation to form mechanically handlable, flexible, transparent, self adhesive and water absorbing hydrogeis of desirable thickness and shape.
  • the gel formation and sterilization occurs simultaneously which has economic advantage as well as the product has very high degree of sterility assurance level.
  • the gel so produced is in final, ready to use pack and does not require further treatment like washing, annealing etc. These gels have tendency to adhere to healthy skin only and not to wet surface like that of a burn wound. This property allows gel dressing to be peeled off painlessly from the wound. Due to transparency, healing of the wound can be observed without removing the gel.
  • the water absorption characteristics of the gel dressing can be controlled by varying concentrations of PVA and natural polymers in the basic formulation.
  • These gels include efficient treatment of burn and injuries due to their excellent cooling effect, biocompatibility, oxygen permeability, absorption, sterility and humid environment which accelerate healing process of the wound. Scar formation is also reduced.
  • These gels can also be used for treatment of trophic ulcers, bed sores, skin contractures, use on donor areas in plastic surgery eczema etc.
  • the hydrogel formed was elastic, mechanically handlable, kin adherent and showed water-absorbing capacity as 125% w/w when measured by method given at the end of the Examples.
  • Example II
  • the PVA and Agar solution was made as in Example I, using 60 gm of PVA of 90,000 molecular weight, acetate content, 0-1 % and 10 gm of agar. The solution was irradiated in the trays at 30 kGy.
  • the hydrogeis produced were like those obtained in Example I, but their water-absorbing capacity in different batches was found 20-30% w/w only.
  • Example III The solution was made as in Example I, using 80 gm of PVA of
  • the hydrogeis produced were similar to those of Example I, but their water-absorbing capacity in different batches was found to be in the range 60-70% w/w only.
  • the hydrogel solution was made as in Example III, using 80 gm of PVA of 1 ,25,000 molecular weight, 12% acetate content, 10 gm of agar, 5 gm of sodium alginate, 10 gm of gum acacia and irradiated at 27 kGy.
  • the hydrogeis produced were similar to those of Example I, but their water-absorbing capacity in different batches was found to be in the range 125-150% w/w only.
  • hydrogeis obtained in these examples are 3-5 mm thick, contain above 80% water and have following characteristics :-
  • the water absorption capacity is determined by removing the hydrogel from its packing and putting into distilled water. The increase in weight is recorded at definite interval of time. The % increase in weight is given by (((Wt - Wo)/Wo)x100) where Wt is the weight of the hydrogel at time t and Wo the weight of the gel before putting it into water. This water absorption is over and above the water originally present in the hydrogel. The absorption values given in the examples are after 12 hours.

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  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un procédé de préparation d'un pansement d'hydrogel par réticulation d'une solution aqueuse de polymère synthétique, à savoir d'un alcool polyvinylique (PVAL) et d'un polymère naturel agar-agar et d'au moins un autre polymère naturel à partir de carraghénane, d'algine et de carboxyméthylcellulose, de gomme acacia ou de polysaccharides analogues ou d'une protéine telle que la gélatine, etc. par rayonnement à faisceaux d'électrons et par rayonnement gamma. Dans ce procédé, les ingrédients sont dissous dans de l'eau distillée et déionisée à des températures élevées. La solution chaude est versée dans un moule en plastique jetable, fermé hermétiquement et soumis à une dose de rayonnement comprise entre 25 et 60 kGy pour donner un pansement, prêt à l'emploi, à teneur en eau élevée, transparent, souple, sous forme de gel auto-adhésif. La solution de gel préalablement irradiée contient 5 à 15 % en poids de PVAL, 0,5 à 5 % en poids de polymères naturels et non moins de 80 % en poids d'eau distillée.
PCT/IN1999/000068 1999-10-27 1999-11-30 Procede de preparation d'hydrogels destines au traitement de brulures et de blessures Ceased WO2001030407A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21277/00A AU2127700A (en) 1999-10-27 1999-11-30 A process for manufacture of hydrogels for burn and injury treatment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN731BO1999 1999-10-27
IN731/BOM/99 1999-10-27

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Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007911A1 (fr) * 2001-07-19 2003-01-30 Veritas Ag Procede de production d'articles en matieres polymeres a effet depot medicamenteux
WO2008059058A1 (fr) * 2006-11-17 2008-05-22 Biomatlante Hydrogel et ses applications biomédicales
WO2008064475A1 (fr) * 2006-11-28 2008-06-05 Ats Biotech Inc. Bandage pour brûlures
CN100423786C (zh) * 2006-11-30 2008-10-08 华南理工大学 阿昔洛韦高分子水凝胶敷料及其制备方法
EP1772483A4 (fr) * 2004-07-23 2008-12-24 San Ei Gen Ffi Inc Composition contenant un composant hydrogel dérivé de gomme arabique
CN100488572C (zh) * 2006-11-30 2009-05-20 华南理工大学 磺胺嘧啶盐高分子水凝胶敷料及其制备方法
WO2009090624A2 (fr) 2008-01-18 2009-07-23 Gynopharm S.A. Gel de chitosane pour applications dermatologiques, procédé d'obtention et d'utilisation de celui-ci
WO2010067378A2 (fr) 2008-12-08 2010-06-17 Reliance Life Sciences Pvt. Ltd. Composition d'hydrogel
DE102010048407A1 (de) 2010-10-15 2012-04-19 Carl Freudenberg Kg Hydrogelierende Fasern sowie Fasergebilde
US8268345B2 (en) * 2008-09-03 2012-09-18 Transdermal Innovations Inc. Multipurpose hydrogel compositions and products
DE102011007528A1 (de) * 2011-04-15 2012-10-18 Aesculap Aktiengesellschaft Thixotrope Zusammensetzung, insbesondere zur postchirurgischen Adhäsionsprophylaxe
CN103071181A (zh) * 2013-02-01 2013-05-01 刘昌桂 一种水凝胶及其制备方法和用途
EP2650413A1 (fr) 2012-04-13 2013-10-16 Carl Freudenberg KG Fibres formant un hydrogel et formation fibreuse
DE102013019888A1 (de) 2013-11-28 2015-05-28 Carl Freudenberg Kg Hydrogelierende Fasern sowie Fasergebilde
CN105496566A (zh) * 2015-12-14 2016-04-20 清华大学 一种医用多层复合防粘连膜及其制备方法
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
IT201600105584A1 (it) * 2016-10-20 2018-04-20 Univ Degli Studi Dellaquila Procedimento di produzione di un bendaggio idrogel confezionato.
CN107987309A (zh) * 2017-11-03 2018-05-04 广州润虹医药科技股份有限公司 一种医用海绵及其制备方法
WO2019195271A1 (fr) * 2018-04-02 2019-10-10 Green Polymers Ltd. Solution polymère liquide pour le traitement de bandes non tissées
CN110387068A (zh) * 2019-08-01 2019-10-29 温州大学 一种石斛多糖纳米纤维素水凝胶
CN111068103A (zh) * 2020-02-06 2020-04-28 牡丹江医学院 一种手术伤口用长效抑菌凝胶敷料及其制备方法
CN111234266A (zh) * 2020-03-11 2020-06-05 河南省科学院同位素研究所有限责任公司 一种壳聚糖/聚乙烯醇水凝胶敷料的制备方法
CN115634304A (zh) * 2022-09-27 2023-01-24 长春吉原生物科技有限公司 一种医用水凝胶产品及其制备方法
CN115785598A (zh) * 2022-12-09 2023-03-14 河北工业大学 一种Janus海绵状水凝胶及其制备方法和应用
CN116440319A (zh) * 2023-05-15 2023-07-18 湖南美媛本草生物工程有限公司 一种医用修复水凝胶的制备方法与应用
CN118267517A (zh) * 2024-06-03 2024-07-02 山东永聚医药科技股份有限公司 阻菌水凝胶伤口敷料及其制备方法
US12129419B2 (en) 2018-11-13 2024-10-29 Polygreen Ltd Polymeric composition for use as soil conditioner with improved water absorbency during watering of the agricultural crops
WO2025129961A1 (fr) * 2023-12-19 2025-06-26 成都大学 Procédé de préparation d'un pansement composite à base d'hydrogel de silicate inorganique bioactif

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Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007911A1 (fr) * 2001-07-19 2003-01-30 Veritas Ag Procede de production d'articles en matieres polymeres a effet depot medicamenteux
US8187513B2 (en) 2001-07-19 2012-05-29 Veritas Ag Method for producing articles consisting of polymer materials having a medicamentous depot effect
EP1772483A4 (fr) * 2004-07-23 2008-12-24 San Ei Gen Ffi Inc Composition contenant un composant hydrogel dérivé de gomme arabique
US20100021544A1 (en) * 2006-11-17 2010-01-28 Biomatlante Hydrogel and biomedical applications thereof
WO2008059058A1 (fr) * 2006-11-17 2008-05-22 Biomatlante Hydrogel et ses applications biomédicales
FR2908775A1 (fr) * 2006-11-17 2008-05-23 Biomatlante Sarl Hydrogel et ses applications biomedicales
US9050392B2 (en) * 2006-11-17 2015-06-09 Biomatlante Hydrogel and biomedical applications thereof
WO2008064475A1 (fr) * 2006-11-28 2008-06-05 Ats Biotech Inc. Bandage pour brûlures
CN100488572C (zh) * 2006-11-30 2009-05-20 华南理工大学 磺胺嘧啶盐高分子水凝胶敷料及其制备方法
CN100423786C (zh) * 2006-11-30 2008-10-08 华南理工大学 阿昔洛韦高分子水凝胶敷料及其制备方法
WO2009090624A2 (fr) 2008-01-18 2009-07-23 Gynopharm S.A. Gel de chitosane pour applications dermatologiques, procédé d'obtention et d'utilisation de celui-ci
US8268345B2 (en) * 2008-09-03 2012-09-18 Transdermal Innovations Inc. Multipurpose hydrogel compositions and products
WO2010067378A2 (fr) 2008-12-08 2010-06-17 Reliance Life Sciences Pvt. Ltd. Composition d'hydrogel
US10092673B2 (en) 2010-10-15 2018-10-09 Carl Freudenberg Kg Hydrogel fibers and fibrous structures
DE102010048407A1 (de) 2010-10-15 2012-04-19 Carl Freudenberg Kg Hydrogelierende Fasern sowie Fasergebilde
WO2012048768A1 (fr) 2010-10-15 2012-04-19 Carl Freudenberg Kg Fibres hydrogélifiantes ainsi que structure fibreuse hydrogélifiante
DE102011007528A1 (de) * 2011-04-15 2012-10-18 Aesculap Aktiengesellschaft Thixotrope Zusammensetzung, insbesondere zur postchirurgischen Adhäsionsprophylaxe
EP2650413A1 (fr) 2012-04-13 2013-10-16 Carl Freudenberg KG Fibres formant un hydrogel et formation fibreuse
DE102012007307A1 (de) 2012-04-13 2013-10-17 Carl Freudenberg Kg Hydrogelierende Fasern sowie Fasergebilde
US9259506B2 (en) 2012-04-13 2016-02-16 Carl Freudenberg Kg Hydrogelling fibers and fibrous structures
CN103071181A (zh) * 2013-02-01 2013-05-01 刘昌桂 一种水凝胶及其制备方法和用途
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
WO2015078538A1 (fr) 2013-11-28 2015-06-04 Carl Freudenberg Kg Fibres hydrogélifiantes et produit à base de fibres hydrogélifiant
DE102013019888A1 (de) 2013-11-28 2015-05-28 Carl Freudenberg Kg Hydrogelierende Fasern sowie Fasergebilde
CN105496566A (zh) * 2015-12-14 2016-04-20 清华大学 一种医用多层复合防粘连膜及其制备方法
IT201600105584A1 (it) * 2016-10-20 2018-04-20 Univ Degli Studi Dellaquila Procedimento di produzione di un bendaggio idrogel confezionato.
EP3311853A1 (fr) * 2016-10-20 2018-04-25 Universita' Degli Studi Dell'Aquila Procédé de production d'un pansement hydrogel emballé
CN107987309A (zh) * 2017-11-03 2018-05-04 广州润虹医药科技股份有限公司 一种医用海绵及其制备方法
CN107987309B (zh) * 2017-11-03 2020-10-16 广州润虹医药科技股份有限公司 一种医用海绵及其制备方法
WO2019195271A1 (fr) * 2018-04-02 2019-10-10 Green Polymers Ltd. Solution polymère liquide pour le traitement de bandes non tissées
CN112512470B (zh) * 2018-04-02 2023-05-05 聚合物绿色有限责任公司 用于处理非织造网的液体聚合物溶液
CN112512470A (zh) * 2018-04-02 2021-03-16 聚合物绿色有限责任公司 用于处理非织造网的液体聚合物溶液
US12129419B2 (en) 2018-11-13 2024-10-29 Polygreen Ltd Polymeric composition for use as soil conditioner with improved water absorbency during watering of the agricultural crops
CN110387068B (zh) * 2019-08-01 2021-06-25 温州大学 一种石斛多糖纳米纤维素水凝胶
CN110387068A (zh) * 2019-08-01 2019-10-29 温州大学 一种石斛多糖纳米纤维素水凝胶
CN111068103A (zh) * 2020-02-06 2020-04-28 牡丹江医学院 一种手术伤口用长效抑菌凝胶敷料及其制备方法
CN111068103B (zh) * 2020-02-06 2020-12-18 牡丹江医学院 一种手术伤口用长效抑菌凝胶敷料及其制备方法
CN111234266A (zh) * 2020-03-11 2020-06-05 河南省科学院同位素研究所有限责任公司 一种壳聚糖/聚乙烯醇水凝胶敷料的制备方法
CN115634304A (zh) * 2022-09-27 2023-01-24 长春吉原生物科技有限公司 一种医用水凝胶产品及其制备方法
CN115634304B (zh) * 2022-09-27 2024-02-13 长春吉原生物科技有限公司 一种医用水凝胶产品及其制备方法
CN115785598A (zh) * 2022-12-09 2023-03-14 河北工业大学 一种Janus海绵状水凝胶及其制备方法和应用
CN115785598B (zh) * 2022-12-09 2024-02-13 河北工业大学 一种Janus海绵状水凝胶及其制备方法和应用
CN116440319A (zh) * 2023-05-15 2023-07-18 湖南美媛本草生物工程有限公司 一种医用修复水凝胶的制备方法与应用
WO2025129961A1 (fr) * 2023-12-19 2025-06-26 成都大学 Procédé de préparation d'un pansement composite à base d'hydrogel de silicate inorganique bioactif
CN118267517A (zh) * 2024-06-03 2024-07-02 山东永聚医药科技股份有限公司 阻菌水凝胶伤口敷料及其制备方法

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