[go: up one dir, main page]

WO2001029537A3 - Method and apparatus for monitoring solid phase chemical reactions - Google Patents

Method and apparatus for monitoring solid phase chemical reactions Download PDF

Info

Publication number
WO2001029537A3
WO2001029537A3 PCT/US2000/028218 US0028218W WO0129537A3 WO 2001029537 A3 WO2001029537 A3 WO 2001029537A3 US 0028218 W US0028218 W US 0028218W WO 0129537 A3 WO0129537 A3 WO 0129537A3
Authority
WO
WIPO (PCT)
Prior art keywords
monitoring
reaction
solid phase
phase chemical
chemical reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/028218
Other languages
French (fr)
Other versions
WO2001029537A2 (en
Inventor
Joanne Elizabeth Anderson
Frank Joseph Tarczynski
Dwight Sherod Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to AU80154/00A priority Critical patent/AU8015400A/en
Priority to EP00970831A priority patent/EP1221037A2/en
Priority to JP2001532079A priority patent/JP2003512615A/en
Publication of WO2001029537A2 publication Critical patent/WO2001029537A2/en
Publication of WO2001029537A3 publication Critical patent/WO2001029537A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00693—Means for quality control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A method for monitoring a solid phase chemical reaction comprises the steps of: (a) providing a reaction mixture comprising a solid support and a reaction medium, (b) contacting an attenuated total reflection element to said reaction mixture; and then (c) monitoring the chemical reaction on the solid support through the attenuated total reflection element. The monitoring step is carried out by attenuated total reflection spectroscopy. An advantage of the invention is that the chemical reaction on the solid support may be directly monitored, rather than indirectly monitoring that chemical reaction by monitoring reaction constituents in the reaction medium.
PCT/US2000/028218 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions Ceased WO2001029537A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU80154/00A AU8015400A (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions
EP00970831A EP1221037A2 (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions
JP2001532079A JP2003512615A (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15967399P 1999-10-15 1999-10-15
US60/159,673 1999-10-15

Publications (2)

Publication Number Publication Date
WO2001029537A2 WO2001029537A2 (en) 2001-04-26
WO2001029537A3 true WO2001029537A3 (en) 2001-11-29

Family

ID=22573502

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028218 Ceased WO2001029537A2 (en) 1999-10-15 2000-10-12 Method and apparatus for monitoring solid phase chemical reactions

Country Status (4)

Country Link
EP (1) EP1221037A2 (en)
JP (1) JP2003512615A (en)
AU (1) AU8015400A (en)
WO (1) WO2001029537A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7283245B2 (en) * 2004-01-20 2007-10-16 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
JP4765059B2 (en) * 2005-02-10 2011-09-07 国立大学法人北海道大学 Cognitive task response measurement system and cognitive task response measurement method
DE102005048807B3 (en) * 2005-10-10 2006-11-16 Johann Wolfgang Goethe-Universität Apparatus for quantitative or qualitative determination of infrared active contents of liquid based or non-liquid fluids
TW200944776A (en) * 2008-03-04 2009-11-01 Kurashiki Boseki Kk Total reflection attenuation type far-ultraviolet spectroscopy and concentration measurement device using the spectroscopy
JP5982663B2 (en) * 2011-12-13 2016-08-31 株式会社Ｕｂｅ科学分析センター Infrared spectrometer for measuring electrolyte of lithium ion secondary battery and measuring method thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US5313264A (en) * 1988-11-10 1994-05-17 Pharmacia Biosensor Ab Optical biosensor system
WO1994019694A1 (en) * 1993-02-19 1994-09-01 Arris Pharmaceutical Corporation Thin film hpmp matrix systems and methods for constructing and displaying ligands
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5780603A (en) * 1996-11-15 1998-07-14 Synsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5817751A (en) * 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
WO1999004228A2 (en) * 1997-07-16 1999-01-28 Ljl Biosystems, Inc. Light detection device
US5942387A (en) * 1996-08-26 1999-08-24 Eli Lilly And Company Combinatorial process for preparing substituted thiophene libraries
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US5313264A (en) * 1988-11-10 1994-05-17 Pharmacia Biosensor Ab Optical biosensor system
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO1994019694A1 (en) * 1993-02-19 1994-09-01 Arris Pharmaceutical Corporation Thin film hpmp matrix systems and methods for constructing and displaying ligands
US5817751A (en) * 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
US5942387A (en) * 1996-08-26 1999-08-24 Eli Lilly And Company Combinatorial process for preparing substituted thiophene libraries
US5780603A (en) * 1996-11-15 1998-07-14 Synsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
WO1999004228A2 (en) * 1997-07-16 1999-01-28 Ljl Biosystems, Inc. Light detection device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIRNBAUM S ET AL: "PEPTIDE SCREENING", CURRENT OPINION IN BIOTECHNOLOGY,GB,LONDON, vol. 3, 1992, pages 49 - 54, XP000651934, ISSN: 0958-1669 *

Also Published As

Publication number Publication date
AU8015400A (en) 2001-04-30
JP2003512615A (en) 2003-04-02
EP1221037A2 (en) 2002-07-10
WO2001029537A2 (en) 2001-04-26

Similar Documents

Publication Publication Date Title
AU5909499A (en) Sampling and analysis of reactions by trapping reaction components on a sorbent
IL133611A0 (en) A method for preparing a substrate for detecting at least one analyte
Na et al. Elimination of trace organic contaminants during enhanced wastewater treatment with horseradish peroxidase/hydrogen peroxide (HRP/H2O2) catalytic process
WO2004103939A8 (en) Assay method and apparatus
WO2003070666A3 (en) Process for making organic products from non-product streams using phase transfer catalysis
WO2002058536A3 (en) Predicting and detecting seizure onsets
WO2003016555A1 (en) Cell diagnosing method, and device and apparatus used for it
WO2003031970A3 (en) Method and apparatus for diagnosing hemostasis
EP1063010A4 (en) Catalyst for removing hydrocarbons in exhaust gas and method for clarification of exhaust gas
AU7441498A (en) Immunoassay apparatus for diagnosis
Kim et al. In situ characterization of the surface reaction between chemisorbed ammonia and oxygen on Pt {100}
AU5844396A (en) Catalytic reaction device, catalytic reaction method, and la minate used for catalytic reaction
WO2003034042A3 (en) Method of monitoring extent of cure of a coating
CA2428821A1 (en) Accessing a platform independent input method editor from an underlying operating system
WO2001029537A3 (en) Method and apparatus for monitoring solid phase chemical reactions
WO2001011360A3 (en) Relaxation of birefringence of magnetic nanoparticles during binding reactions
BR0012874A (en) Raman analysis system for olefin polymerization control
WO2003038436A3 (en) Microfluidic ser(r)s detection
CA2402175A1 (en) A method for performing positioning and an electronic device
WO2003010513A1 (en) Solution density measuring method, sample cell used for the method, and solution density measuring device
WO2002077636A3 (en) Volatile signature detector and associated methods
AU2002223169A1 (en) Method for detecting molecules or chemical reactions by determining variation ofconductance
WO2005007882A3 (en) Sample preparing unit
WO2005056836A3 (en) Method for generating a predetermined amount of nucleic acid
EP1033568A3 (en) Method and device for active substance search

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10070633

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2000970831

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2001 532079

Country of ref document: JP

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2000970831

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000970831

Country of ref document: EP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)