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WO2001026550A1 - Dispositif permettant la mise sous pression, la recolte et le dosage d'echantillons liquides - Google Patents

Dispositif permettant la mise sous pression, la recolte et le dosage d'echantillons liquides Download PDF

Info

Publication number
WO2001026550A1
WO2001026550A1 PCT/PL2000/000066 PL0000066W WO0126550A1 WO 2001026550 A1 WO2001026550 A1 WO 2001026550A1 PL 0000066 W PL0000066 W PL 0000066W WO 0126550 A1 WO0126550 A1 WO 0126550A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
needle
holder
valve
syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/PL2000/000066
Other languages
English (en)
Inventor
Waldemar Pakszys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU75632/00A priority Critical patent/AU7563200A/en
Publication of WO2001026550A1 publication Critical patent/WO2001026550A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A61B5/1545—Devices using pre-evacuated means comprising means for indicating vein or arterial entry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A61B5/150519—Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150572—Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150633—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves
    • A61B5/150641—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves comprising means to impede repositioning of protection sleeve from covering to uncovering position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150732—Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube

Definitions

  • This invention relates to a device for underpressuring collection and dosage liquid samples, in particular for collection blood samples from a patient's vein for analytic tests or dosage remedy liquids into a blood vascular system or any body cavity.
  • the European patent No. 0191945 discloses a blood sampling device comprising a cylindrical sample tube and slidable therein a plunger and also comprising an end cap on which there is eccentrically disposed an axially directed cone.
  • the device comprises an adapter fitted on the cone and having two cannulae secured thereon, the outer cannula being free for introduction into a vein while the inner cannula is closed by a tyre valve.
  • the device comprises also a non-retum valve which is disposed in the end cap and which consists of an elastically deformable diaphragm having a central valve aperture and a cylindrical support ring for the diaphragm, said ring being inserted into the end cap, the diaphragm and the support ring being constructed as a one-piece diaphragm ring and the diaphragm being disposed in the support ring so as to be inwardly offset and being externally formed as a spherical segment such as to project somewhat beyond the edge of its support ring and a circular valve seat integrally formed concentrically on the inside of the end cap.
  • WO 95/16395 discloses a holding fixture for a blood sample collection tube of a blood-taking device which has a collecting container, with needle carrier, for a front end of the blood sample collection tube, which is closed off by a closure device.
  • a needle carrier mounted in the needle carrier is a syringe directed toward the opened end of the collecting container and projecting in its direction.
  • a connecting passage formed between the needle carrier and a front wall of the collecting container links a flow channel with a collecting needle of a needle arrangement that is excentric to a central longitudinal axis of the collecting chamber.
  • an openable valve arrangement is situated between the connecting passage and a collecting chamber. This valve arrangement is formed by a tube valve or flap valve disposed between the syringe and the collecting container and/or the connecting passage.
  • the syringe is preferably set concentric to the collecting container.
  • the flow channel feeds into the connecting passage between the syringe and an outer wall of the collecting container.
  • a device for underpressuring collection and dosage liquid samples comprises three parts i.e. a holder, a blood sample collection tube-syringe on the one side of the holder and a needle arrangement on the other side of the holder.
  • the holder comprises a set of two valves.
  • the first valve on the tube-syringe's side is a tyre valve and the second valve on the side of the needle is a membrane valve.
  • These parts of the device according to the invention are shown in figures 1, 2 and 3.
  • the device comprises also an opening needle head.
  • the holder of the device with the needle arrangement comprises a guide bar (1) which is open on the one side and on the other side has a conic head (2) with an inner channel (3) for mounting the needle (4).
  • a seating (5) which has on its frontal surface, from the side of the conic heat (2), the membrane valve.
  • the membrane valve comprises a membrane (6) and an under-support (7) placed in a recess on the frontal surface of the seating (5) where the under-support (7) has a form of the sleeve with side-inlets (8) and it has also a under-membrane chamber (9) in the seating (5) under the membrane (6).
  • the under-support (7) is formed by a number of separate supports (10) which are distributed in the same distance from the axis of the membrane (6). Moreover, the thickness of the membrane (6) on its periphery is considerably smaller than in the central part or the thickness of the membrane (6) is smaller outside the under-support (7).
  • the seating (5), the membrane (6) and the under-support (7) with side-inlets (8) or separate supports (10) form a counter-reversible membrane valve.
  • On the other side of the seating (5) there is placed a tyre valve comprising an inner needle (11 ) covered by a tyre (12) where the axis of the inner needle (11 ) is in principle in line with the axis of the membrane (6).
  • the conic head (2) has, on the seating's side, a top- support (13) of the membrane (6) whose position is in line with the position of the under-support (7).
  • the holder of the device has further a shield (14) which is placed on the guide bar (1) of the holder and has an opening for the conic head (2) in its top part.
  • the shield (14) is joined with the guide bar (1) by upper latches (15) and lower latches (16).
  • the shield (14) has in its upper part an observation window (17) for observation of the liquid collected from blood vascular system or any body cavity which is collected in an initial collection liquid chamber (18) between the conic head (2) and the seating (5).
  • the shield (14) and the guide bar (1) have in their lower part an opening (19) for observation of a liquid material in the tube-syringe inserted in the holder.
  • the guide bar (1) has in its lower part a stabilising flange (20).
  • a blood sample collection tube-syringe of the device is presented in fig.3.
  • the blood sample collection tube-syringe comprises a transparent sleeve (21) wherein a piston (22) with a piston rod (23) is placed.
  • the piston (22) is ended by a tie (24) outside the sleeve (21).
  • the piston rod (23) has a blocking (25) which is in a cut-out (26) of the bottom of the sleeve (21) in an extreme position of the piston rod (23).
  • the piston rod (23) has a reduction (27) close behind the blocking (25).
  • the second, opened end of the transparent sleeve (21) is coated by a rubber plug (28) having an inner cleaning chamber (29).
  • a complete device which is shown in figures 6 and 7 comprises the holder with the blood sample collection tube-syringe and the needle arrangement.
  • the tyre (12) and the rubber plug (28) are perforated by the inner needle (11) and the inside of the sleeve (21) of the blood sample collection tube-syringe is connected with the counter-reversible membrane valve.
  • Figure 8 shows the holder with the shield (14) which is joined with the guide bar (1) by upper latches (15), said shield being a security container (30) for the needle (4).
  • the needle (4) is mounted on the conic head (2) and introduced into blood vascular system or any body cavity with liquid content.
  • a liquid sample of the blood or organism liquids collected by the needle (4) flows into the initial collection liquid chamber (18) between the top- support (13) and the membrane (6) by a culvert recess in this top-support (13).
  • the liquid sample in the chamber (18) is observed by the observation window (17).
  • the blood sample collection tube-syringe is introduced into the holder by the opening (19) of the shield (14) and the guide bar (1).
  • the negative pressure created in the sleeve (21) of the blood sample collection tube-syringe by the piston (22), the piston rod (23) and the tie (24) causes that the edges of the membrane (6) are deviated downwards, as it is shown in figure 6, and the liquid content is sucked into the sleeve (21) of the blood sample collection tube-syringe.
  • the liquid content in the blood sample collection tube-syringe is observed in the holder through the opening (19) of the shield (14) and the guide bar (1 ).
  • the blood sample collection tube-syringe with the liquid content is further removed from the holder of the device and delivered for analytic tests.
  • a device according to the invention may also be used for dosage liquid samples, in particular any remedy liquids.
  • the remedy liquid is sucked into the blood sample collection tube-syringe.
  • the tube-syringe with the remedy liquid is placed in the holder and an opening needle heat with new needle is placed on the conic head (2) of the holder. Therefore, this device with the opening needle head placed between the conic head (2) and the needle (4) is adapted to the dosage the remedy liquid.
  • the opening needle head as shown in figure 9, comprises a conic sleeve (31 ) with a head part (32) which is formed as the conic head (2) of the holder and a lower part (33) which is placed on the conic head (2) of the holder, an opening needle (34) being placed inside of the conic sleeve (31 ), in its lower part.
  • the axis of the opening needle (34) passes through the membrane (6) and is in principle in line with the axis of the inner needle (11).
  • the opening needle (34) perforates membrane (6) and connect the inner needle (11) with a new needle (4) by the under-membrane chamber (9).
  • the tube-syringe with the remedy liquid is placed in such a modified device and after perforation of the tyre (12) and opening the passage between the inside of the sleeve (21) with the remedy liquid and the new needle (4), the content of the tube-syringe is dosed by a dislodging movement of the piston (22) into blood vascular system or any body cavity.
  • Fig.l shows a holder of a device for underpressuring collection and dosage liquid samples with a needle arrangement
  • Fig.2 shows the holder in section A-A in fig.1 ;
  • Fig.3 shows a blood sample collection tube-syringe of the device
  • Fig.4 shows a seating of the valve with a inner needle
  • Fig.5 shows the seating of the valve in top view
  • Fig.6 shows the holder with the blood sample collection tube-syringe and the needle arrangement
  • Fig.7 shows the holder in section B-B in fig.6;
  • Fig.8 shows the holder with a shield
  • Fig.9 shows an opening needle head
  • Fig.10 shows the holder with the opening needle head.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Manufacturing & Machinery (AREA)
  • Vascular Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif permettant la mise sous pression, la récolte et le dosage d'échantillons liquides, destiné notamment à des tests analytiques. Le dispositif comporte d'un côté un support doté d'une seringue (4) de récolte d'échantillon sanguin et de l'autre, un agencement d'aiguille (11, 12). Le support comporte un ensemble de deux clapets, le premier clapet sur la seringue étant un clapet pneumatique et le second clapet sur le côté de l'aiguille étant un clapet à membrane (6, 7, 8) doté d'une membrane (6) placée sur un support inférieur (7) ayant des entrées latérales (8). L'avantage de la présente invention est le fait qu'après inspection de l'injection correctement réalisée dans le système vasculaire ou dans toute cavité du corps, par la fenêtre d'observation, la matière liquide s'écoule dans la seringue de collecte d'échantillon sanguin librement, sans retour possible. Le blindage du support est, en outre, un récipient de sécurité pour les aiguilles usagées. Le présent dispositif peut s'utiliser pour le dosage de liquides thérapeutiques au moyen d'une tête d'aiguille d'ouverture additionnelle.
PCT/PL2000/000066 1999-10-11 2000-10-06 Dispositif permettant la mise sous pression, la recolte et le dosage d'echantillons liquides Ceased WO2001026550A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU75632/00A AU7563200A (en) 1999-10-11 2000-10-06 A device for underpressuring and collection and dosage liquid samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PLP.335924 1999-10-11
PL99335924A PL185997B1 (pl) 1999-10-11 1999-10-11 Zestaw do podciśnieniowego pobierania i dozowaniapróbek płynnych, zwłaszcza krwi, do badań analitycznych

Publications (1)

Publication Number Publication Date
WO2001026550A1 true WO2001026550A1 (fr) 2001-04-19

Family

ID=20075246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2000/000066 Ceased WO2001026550A1 (fr) 1999-10-11 2000-10-06 Dispositif permettant la mise sous pression, la recolte et le dosage d'echantillons liquides

Country Status (5)

Country Link
US (1) US6579245B1 (fr)
AU (1) AU7563200A (fr)
DE (1) DE10048126B4 (fr)
PL (1) PL185997B1 (fr)
WO (1) WO2001026550A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7456024B2 (en) 2001-08-29 2008-11-25 Hexal Pharma Gmbh Method and device for preparing a sample of biological origin in order to determine at least one constituent contained therein
CN101327350B (zh) * 2003-02-13 2010-10-13 许明正 具有注射及抽血功能的安全器械

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6814707B2 (en) * 2001-06-20 2004-11-09 Margie M. Collins Blood collection safety device
WO2005076733A2 (fr) * 2004-02-17 2005-08-25 Uri Carmi Dispositif de prelevement sanguin a deux modes
WO2006007305A2 (fr) * 2004-06-07 2006-01-19 Edwards Lifesciences Corporation Procedes et dispositifs pour effectuer une ablation ciblee de tissu
ITRM20040397A1 (it) * 2004-08-04 2004-11-04 Univ Roma Dispositivo monouso per una o piu' introduzioni, trattamento e prelievi di materiale biologico da almeno una delle fasi di separazione, presenti all'interno del dispositivo, in condizioni di sterilita' e a pressione costante.
US20080108954A1 (en) * 2006-11-02 2008-05-08 Jean-Marie Mathias Flow Controllers
US20090218535A1 (en) * 2008-02-27 2009-09-03 Andres Pasko Flow controllers for fluid circuits
EP2315824A4 (fr) * 2008-08-26 2012-08-22 Wako Pure Chem Ind Ltd Appareil jetable pour la préparation automatisée d un échantillon biologique
ES2593042B1 (es) * 2015-06-03 2017-10-03 Biotechnology Institute, I Mas D, S.L. Dispositivo de recolección de sangre o de un compuesto sanguíneo
CN107582075A (zh) * 2017-10-28 2018-01-16 刘贞宽 一次性使用笔杆式安全防逆流型静脉采血针
CN114364783A (zh) 2019-08-06 2022-04-15 Bd科斯特公司 用于给密封容器通风并且从其中取样的一次性装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212308A (en) * 1977-12-27 1980-07-15 Becton, Dickinson And Company Parallel-flow one-way blood sampling device
US4295477A (en) * 1979-08-15 1981-10-20 Becton, Dickinson And Company Multiple sampling device having molded valve and hub
EP0191945A2 (fr) 1985-02-20 1986-08-27 KABE Labortechnik Gesellschaft mit beschränkter Haftung Dispositif pour le prélèvement d'échantillons sanguins
WO1995016395A1 (fr) 1993-12-16 1995-06-22 C.A. Greiner & Söhne Gesellschaft M.B.H. Systeme de fixation pour tube de prelevement sanguin d'un dispositif pour prise de sang
DE19520883A1 (de) * 1995-06-08 1996-12-12 Szibor Reinhard Prof Dr Vorrichtung zur Blutentnahme mit einem zweikammrigen System

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154229A (en) * 1977-08-10 1979-05-15 Becton, Dickinson And Company Blood collection system with venipuncture indicator
US4207870A (en) * 1978-06-15 1980-06-17 Becton, Dickinson And Company Blood sampling assembly having porous vent means vein entry indicator
US4307731A (en) 1978-06-15 1981-12-29 Becton, Dickinson And Company Multiple sampling needle having one-way valve
US4421123A (en) 1981-11-30 1983-12-20 Becton Dickinson And Company Multiple sample needle valve
US4998920A (en) * 1989-10-11 1991-03-12 Delores Johnson Protective assembly for hypodermic syringe devices
US5356392A (en) * 1990-05-09 1994-10-18 Safety Syringes, Inc. Shielded blood collection tube holder
US6004278A (en) * 1996-12-05 1999-12-21 Mdc Investment Holdings, Inc. Fluid collection device with retractable needle

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212308A (en) * 1977-12-27 1980-07-15 Becton, Dickinson And Company Parallel-flow one-way blood sampling device
US4295477A (en) * 1979-08-15 1981-10-20 Becton, Dickinson And Company Multiple sampling device having molded valve and hub
EP0191945A2 (fr) 1985-02-20 1986-08-27 KABE Labortechnik Gesellschaft mit beschränkter Haftung Dispositif pour le prélèvement d'échantillons sanguins
WO1995016395A1 (fr) 1993-12-16 1995-06-22 C.A. Greiner & Söhne Gesellschaft M.B.H. Systeme de fixation pour tube de prelevement sanguin d'un dispositif pour prise de sang
DE19520883A1 (de) * 1995-06-08 1996-12-12 Szibor Reinhard Prof Dr Vorrichtung zur Blutentnahme mit einem zweikammrigen System

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7456024B2 (en) 2001-08-29 2008-11-25 Hexal Pharma Gmbh Method and device for preparing a sample of biological origin in order to determine at least one constituent contained therein
CN101327350B (zh) * 2003-02-13 2010-10-13 许明正 具有注射及抽血功能的安全器械

Also Published As

Publication number Publication date
PL335924A1 (en) 2001-04-23
DE10048126A1 (de) 2001-04-12
AU7563200A (en) 2001-04-23
PL185997B1 (pl) 2003-09-30
DE10048126B4 (de) 2010-04-22
US6579245B1 (en) 2003-06-17

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