[go: up one dir, main page]

WO2001025407A3 - Tyrosine-adn- phosphodiesterases (tdp) et polypeptides, acides nucleiques, vecteurs, cellules hotes produisant du tdp, anticorps apparentes et procedes d'utilisation - Google Patents

Tyrosine-adn- phosphodiesterases (tdp) et polypeptides, acides nucleiques, vecteurs, cellules hotes produisant du tdp, anticorps apparentes et procedes d'utilisation Download PDF

Info

Publication number
WO2001025407A3
WO2001025407A3 PCT/US2000/027400 US0027400W WO0125407A3 WO 2001025407 A3 WO2001025407 A3 WO 2001025407A3 US 0027400 W US0027400 W US 0027400W WO 0125407 A3 WO0125407 A3 WO 0125407A3
Authority
WO
WIPO (PCT)
Prior art keywords
tdp
tyrosine
antibodies
vectors
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/027400
Other languages
English (en)
Other versions
WO2001025407A2 (fr
Inventor
Jeffrey Pouliot
Howard A Nash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Priority to AU10732/01A priority Critical patent/AU1073201A/en
Priority to US10/110,176 priority patent/US7087736B1/en
Publication of WO2001025407A2 publication Critical patent/WO2001025407A2/fr
Publication of WO2001025407A3 publication Critical patent/WO2001025407A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne une molécule d'acide nucléique codant pour une tyrosine-ADN phosphodiestérase (TDP), et un vecteur, une cellule hôte, un polypeptide, un anticorps, une molécule d'acide nucléique antisens, et un ribozyme apparentés. L'invention concerne également un procédé de modification du niveau de TDP dans une cellule, un tissu, un organe ou organisme, ainsi que la cellule, le tissu, l'organe ou l'organisme non-humain obtenus, et un procédé d'identification d'un composé résistant au TDP, un procédé d'évaluation de l'activité de TDP1 chez un animal. Et un procédé d'évaluation de l'efficacité d'un inhibiteur de la topoisomérase I.
PCT/US2000/027400 1999-10-05 2000-10-05 Tyrosine-adn- phosphodiesterases (tdp) et polypeptides, acides nucleiques, vecteurs, cellules hotes produisant du tdp, anticorps apparentes et procedes d'utilisation Ceased WO2001025407A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU10732/01A AU1073201A (en) 1999-10-05 2000-10-05 Tyrosine-dna phosphodiesterases (tdp) and related polypeptides, nucleic acids, vectors, tdp-producing host cells, antibodies and methods of use
US10/110,176 US7087736B1 (en) 1999-10-05 2000-10-05 Tyrosine DNA phosphodiesterases (TDP) and related polypeptides nucleic acids vectors TDP producing host cells antibodies and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15769099P 1999-10-05 1999-10-05
US60/157,690 1999-10-05

Publications (2)

Publication Number Publication Date
WO2001025407A2 WO2001025407A2 (fr) 2001-04-12
WO2001025407A3 true WO2001025407A3 (fr) 2001-11-29

Family

ID=22564851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/027400 Ceased WO2001025407A2 (fr) 1999-10-05 2000-10-05 Tyrosine-adn- phosphodiesterases (tdp) et polypeptides, acides nucleiques, vecteurs, cellules hotes produisant du tdp, anticorps apparentes et procedes d'utilisation

Country Status (2)

Country Link
AU (1) AU1073201A (fr)
WO (1) WO2001025407A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105053A1 (en) * 2001-08-08 2003-06-05 Burgin Alex B. Therapeutic compositions and screening methods relating to 3' -tyrosyl-DNA-phosphodiesterase
WO2003031579A2 (fr) * 2001-10-05 2003-04-17 Keck Graduate Institute Of Applied Life Sciences Polypeptides de variant de phosphodiesterase d'adn de tyrosine humaine et techniques d'utilisation de ceux-ci

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018541A1 (fr) * 1991-04-19 1992-10-29 The Board Of Regents Of The University Of Washington Adn codant des phosphodiesterases chez les mammiferes
WO1997015676A2 (fr) * 1995-10-27 1997-05-01 Abbott Laboratories Gene de la topoisomerase i de candida

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018541A1 (fr) * 1991-04-19 1992-10-29 The Board Of Regents Of The University Of Washington Adn codant des phosphodiesterases chez les mammiferes
WO1997015676A2 (fr) * 1995-10-27 1997-05-01 Abbott Laboratories Gene de la topoisomerase i de candida

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ABOUSSEKHRA A ET AL: "A NOVEL ROLE FOR THE BUDDING YEAST RAD9 CHECKPOINT GENE IN DNA DAMAGE-DEPENDENT TRANSCRIPTION", EMBO JOURNAL,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 15, no. 15, 1996, pages 3912 - 3922, XP000942139, ISSN: 0261-4189 *
DATABASE EMBL 13 September 1999 (1999-09-13), STRAUSBERB ROBERT, XP002161091 *
DATABASE EMBL 6 September 1994 (1994-09-06), DUBOIS E.: "S.cerevisiae chromosome II reading frame ORF YBR223c", XP002161092 *
DATABASE SWALL SWALL:Q19973; 1 November 1996 (1996-11-01), WILSON R.: "Caenorhabditis elegans", XP002161093 *
FELDMANN H ET AL: "COMPLETE DNA SEQUENCE OF YEAST CHROMOSOME II", EMBO JOURNAL,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 13, no. 24, 15 December 1994 (1994-12-15), pages 5795 - 5809, XP000942152, ISSN: 0261-4189 *
KNAB A M ET AL: "MECHANISMS OF CAMPTOTHECIN RESISTANCE IN YEAST DNA TOPOISOMERASE I MUTANTS*", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 268, no. 30, 25 October 1993 (1993-10-25), pages 22322 - 22330, XP000567890, ISSN: 0021-9258 *
MEGONIGAL M D ET AL: "ALTERATIONS IN THE CATALYTIC ACTIVITY OF YEAST DNA TOPOISOMERASE I RESULT IN CELL CYCLE ARREST AND CELL DEATH", JOURNAL OF BIOLOGICAL CHEMISTRY,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD,US, vol. 272, no. 19, 9 May 1997 (1997-05-09), pages 12801 - 12808, XP000942084, ISSN: 0021-9258 *
POULIOT J J ET AL: "YEAST GENE FOR A TYR-DNA PHOSPHODIESTERASE THAT REPAIRS TOPOISOMERASE I COMPLEXES", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 552 - 555, XP000941785, ISSN: 0028-0836 *
WANG JAMES C: "DNA topoisomerases.", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 65, 1996, 1996 Annual Reviews Inc. P.O. Box 10139, 4139 El Camino Way, Palo Alto, California 94306, USA, pages 635 - 692, XP002161090, ISBN: 0-8243-0865-4 *
WILSON R ET AL: "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 368, 3 March 1994 (1994-03-03), pages 32 - 38, XP002119914, ISSN: 0028-0836 *
YANG SHU-WEI ET AL: "A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 93, no. 21, 1996, 1996, pages 11534 - 11539, XP000942086, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2001025407A2 (fr) 2001-04-12
AU1073201A (en) 2001-05-10

Similar Documents

Publication Publication Date Title
WO2002077011A3 (fr) Variants proteiques vert fluorescent, sensibles a l'oxydoreduction
WO2002031134A3 (fr) Nouveaux genes de serine protease apparentes a la dppiv
WO2001079463A3 (fr) Acides nucleiques codant pour des polypeptides ayant une activite haloperoxydase
WO2003089598A3 (fr) Polypeptides a activite xyloglucanase, et acides nucleiques codant ceux-ci
BR9813608B1 (pt) célula hospedeira de bacillus transgênica, e, processo para produzir um polipeptìdeo tendo atividade aminopeptidase.
CA2403817A1 (fr) Procede modulant la croissance du cheveu
WO2001079462A3 (fr) Acides nucleiques codant pour des polypeptides presentant une activite haloperoxydase
WO2000060060A3 (fr) Polypeptides presentant une activite alcaline alpha-amylase et acides nucleiques les codant
DK1131444T3 (da) Polypeptider med lysophospholipase aktivitet og nucleinsyre som koder for disse
WO2000012726A3 (fr) Heparinases a conception rationnelle derivees de l'heparinase i et ii
WO1999043808A8 (fr) Compositions de c-maf humaine et leurs methodes d'utilisation
WO2003050260A3 (fr) Fusions de genes exprimees par la streptavidine et leurs procedes d'utilisation
ATE331791T1 (de) Phosphodiesterase 10
WO2001083702A3 (fr) Nouveaux membres de la famille des lysyl-oxydases des applications se rapporatnt aux amine-oxydases
WO2004009788A3 (fr) Proteines fluorescentes, acides nucleiques les codant, et procedes de fabrication et d'utilisation correspondants
WO2000077239A3 (fr) Nouveaux genes codant pour des proteines a des fins de diagnostic, de prevention, de therapie et autres
WO2001098469A3 (fr) Polypeptides presentant une activite de la peroxydase et acides nucleiques codant pour ces polypeptides
WO2005012482A3 (fr) Essai d'identification de composes bioactifs qui interagissent avec la proteine du stress 90
WO2000028043A3 (fr) Polypeptides presentant une activite lactonohydrolase et acides nucleiques codant ces polypeptides
WO2001025407A3 (fr) Tyrosine-adn- phosphodiesterases (tdp) et polypeptides, acides nucleiques, vecteurs, cellules hotes produisant du tdp, anticorps apparentes et procedes d'utilisation
CA2366523A1 (fr) Procede d'analyse de la quantite de tissu adipeux intra-abdominal
ATE345382T1 (de) 2,6-beta-d-fruktanhydrolase enzym und verfahren zu dessen verwendung
WO2000041509A3 (fr) Polypeptides possedant une activite de phosphatase acide et acides nucleiques codant pour ceux-ci
WO2004039990A3 (fr) Analyse de gene rapporteur, kit, et cellules permettant de determiner la presence et/ou le niveau d'une molecule qui active l'activite de transduction du signal d'une proteine de surface cellulaire
WO2001042285A3 (fr) Matrice extracellulaire et molecules d'adherence cellulaire

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10110176

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP