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WO2001024851A1 - Catheter pour la delivrance de medicaments - Google Patents

Catheter pour la delivrance de medicaments Download PDF

Info

Publication number
WO2001024851A1
WO2001024851A1 PCT/US1999/022676 US9922676W WO0124851A1 WO 2001024851 A1 WO2001024851 A1 WO 2001024851A1 US 9922676 W US9922676 W US 9922676W WO 0124851 A1 WO0124851 A1 WO 0124851A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
patient
drug delivery
delivery device
medical system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/022676
Other languages
English (en)
Inventor
Russell W. Bowden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cormedica Corp
Original Assignee
Cormedica Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cormedica Corp filed Critical Cormedica Corp
Priority to PCT/US1999/022676 priority Critical patent/WO2001024851A1/fr
Priority to AU65033/99A priority patent/AU6503399A/en
Publication of WO2001024851A1 publication Critical patent/WO2001024851A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • A61B5/062—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using magnetic field
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585—Needle inserters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1588—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body having means for monitoring, controlling or visual inspection, e.g. for patency check, avoiding extravasation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0089—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M2025/0166—Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0662—Guide tubes
    • A61M2025/0681—Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A61M2210/125—Heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0133—Tip steering devices
    • A61M25/0144—Tip steering devices having flexible regions as a result of inner reinforcement means, e.g. struts or rods

Definitions

  • the present invention relates to a catheter for treatment of a patient and a related process. More specifically, the catheter is used to supply angiogenic substances to revascularize ischemic areas of a patients' heart.
  • Various techniques are used to deliver substances such as medical drugs to a patient.
  • a common technique is for the patient to orally ingest the medicinal substance.
  • medicine is supplied to the patient intravenously by having a needle injecting medicine into the patient's bloodstream.
  • Oral ingestion or supplying medicine into the patient's bloodstream work well for various kinds of medication and various kinds of ailments.
  • other situations require that medication be targeted to a particular body location (i.e., organ, part of organ, etc. of the patient) . This may be necessary or advisable if the medicinal effect is dissipated by general dispersal of the medicine throughout the patient.
  • Medicinal drugs may require concentrating doses in particular parts of the body for maximum medicinal effects. Some drugs require targeting or concentrating doses at desired locations because the drug is so expensive that it is not practical to apply it to regions of the body except those that need it. Drugs may require targeting particular parts of the body to reduce side effects or effects on portions of the body not in need of the medication.
  • the targeting of drugs to specific locations may be accomplished in various ways. Sometimes medicines are supplied to the patient by indirect targeting so that they are concentrated in the targeted part of the body. Such concentration at a desired site may arise from natural properties of the medicine or from chemical agents added to the medicine for the purpose of directing concentration towards a particular location. Other times the medicine is directly applied to the targeted part of the body.
  • An example of such direct targeting is where a medication for a sore muscle may be injected directly into a muscle of the patient using a needle.
  • direct targeting shall mean application of drugs physically at the target site, instead of using indirect targeting which uses insertion of the drugs at one or more body locations and bodily processes such as blood flow to carry the drugs to a desired location different from the sites of application of the drugs.
  • a medical treatment requires application of a drug to a given small surface area of an internal organ and the drug applicator can localize the drug application to a surface area of the required size, there may still be a problem- if the applicator applies the drug with an offset from the specific small surface area that is the target.
  • Such an offset is common if the technique used for locating and positioning the applicator is imprecise. If the applicator can be located reliably within 20 mm, but a given situation calls for drug application in a radius of 10 mm about a point, the applicator may apply all of the drug outside the target area.
  • a more specific object of the present invention is to provide a catheter with highly localized direct targeting of a drug.
  • a further object of the present invention is to provide a catheter allowing quite precise direct targeting of a drug.
  • Yet another object of the present invention is to provide a catheter allowing precise and localized delivery of angiogenic substances to within a patient's heart.
  • a further object of the present invention is to provide a drug applying catheter providing a high level of stability when set in a position.
  • Yet another object of the present invention is to provide a drug applying catheter which is easy to position and to move between desired positions.
  • the drug delivery device is preferably a catheter.
  • the catheter includes a housing and a needle at least partly within the housing.
  • the needle is slidable relative to the housing such that it is movable between a retracted position completely within the housing and an extended position at least partly out of the housing.
  • An outer catheter is optionally used with the inner or drug delivery catheter slidable within the outer catheter.
  • the outer catheter includes a spring for steering the outer catheter position in a patient's heart.
  • the invention may alternately be described as a medical system for treating a patient including: a drug delivery device for percutaneous application of drug by direct targeting injection into interior tissue of a patient by at least part of the drug delivery device extending into the tissue, the drug delivery device having a proximal end and a distal end; and a spring disposable within a patient for steering the position of the drug delivery device inside of a patient.
  • a tracking system is operable to track the location of the distal end within the patient and has one or more device transducers at the distal end of the drug delivery device and one or more external transducers.
  • the invention may alternately be described as a method of applying angiogenic drugs percutaneously to heart wall tissue of a patient, the steps including: percutaneously inserting a drug delivery device into the patient, the drug delivery device having distal and proximal ends; positioning the distal end within the heart of a patient and at a target location as determined by using a tracking system to track the location of the distal end within the patient, the tracking system having one or more device transducers at the distal end of the drug delivery device and one or more external transducers, the location of the distal end being sensed by electromagnetic interactions of the device transducer(s) and the external transducer(s) ; and injecting by direct targeting injection an angiogenic drug into heart tissue of a patient by having at least part of the drug delivery device extending into the heart tissue.
  • the drug delivery device is a catheter, the catheter has a needle and the injecting step is performed by moving the needle from a retracted position within a housing of the catheter and an extended position with at least part of the needle extending into heart tissue.
  • the catheter is within an outer catheter and the positioning step includes sliding the catheter relative to the outer catheter.
  • the positioning step includes use of a spring within the patient in order to steer the catheter such that a distal tip of the catheter is in a proper position (i.e., proper site for injection) relative to the heart wall prior to injection.
  • FIG. 2 is a side cross section view of the distal end of the catheter of FIG. 1 with a needle extended and combined with a pressure source;
  • FIG. 3 is a side view wherein the catheter of FIG. 1 is an inner catheter within an outer catheter;
  • FIG. 4 is a side view of the catheter as used to insert a stent.
  • FIG. 5 is a simplified side view of an alternate embodiment where an insertable member is a stent or plug having a needle built into it by virtue of the shape of the stent or plug.
  • a drug applicator 10 which is more specifically a catheter, includes a tubular outer housing 12 of flexible material as commonly used for catheters and a tubular inner housing 14 of the same material. As shown, the inner housing 14 does not extend as far in the distal (rightmost in the FIG.) distance as the outer housing 12.
  • a tip electrode 16 is disposed at the distal tip and may be made of platinum or gold.
  • a sensor coil 18 is disposed in the outer housing 12.
  • the electrode wires and sensor wires are not shown for ease of illustration, but such wires would extend to a proximal end (not shown) of the catheter.
  • the catheter 10 will have the anchoring arrangement disclosed in Abela, Bowden et al. U. S. Patent 5,782,824 issued July 21, 1998. That patent, which is incorporated by reference, discloses a laser catheter having a spring in an outer catheter and an inner catheter which is movable relative to the outer catheter.
  • the spring in the outer catheter is used for anchoring the outer catheter in a stable position and for steering the outer catheter(the inner catheter being steered in turn by the steering of the outer catheter) , but the catheter provides for sliding movement of the inner catheter relative to the outer catheter and a windshield wiper movement back and forth as an anchoring point of the outer catheter remains stable.
  • the construction of the present catheter is like that of the '824 patent except where noted.
  • One difference is that the present invention does not need the windshield wiper type movement.
  • spring as used in the present invention provides the steering functions of the spring of the '824 patent, but usually would not need provide the anchoring and biasing (i.e., pressing the distal tip of the catheter into the wall) functions of the spring in that patent.
  • the catheter 10 is the inner catheter in such a construction, whereas an outer catheter 20 having spring 22 for steering is used like the outer catheter of the '824 patent.
  • the inner catheter 10 also referred to as a drug delivery catheter
  • the inner catheter 10 has a needle, instead of the optical fiber arrangement of the '824 patent.
  • the spring 22 could alternately be directly in the drug delivery catheter 10 without the use of any outer catheter like 20.
  • the catheter 10 cooperates with an external transducer system 24 which may have one or more coils or other transducers (not shown) .
  • the external transducer system 24 and the catheter sensing coil 18 are part of a navigation system (not shown) allowing one to use interaction between transducers such as coil 18 on the catheter and external transducers to precisely calculate the position of the catheter 10.
  • a navigation system is that disclosed in U.S. Patent application serial no. 08/996,125 filed December 22, 1997 in the name of Mark Schneider and assigned to the present assignee.
  • a broader discussion of an earlier version of the navigation system in also disclosed in U.S. Patent 5,769,843 issued June 23, 1998 in the names of Abela and Bowden and assigned to the present assignee. That application and the '843 patent are hereby incorporated by reference.
  • the present invention would use the navigation or position sensing arrangement of the Schneider application such that details need not be discussed.
  • the catheter 10 has a needle 26 and a tube 28 extending to the proximal end.
  • the tube 28 is connected to a needle control 30 which is simply a grip or holder allowing one to slide the tube 28 within the catheter 10.
  • the details of the needle control 30 are not shown, but may be like the control used for translating an inner catheter relative to an outer catheter in the '824 patent.
  • the tube 28 is connected to a pressure or medicine source 30 such that drugs are supplied to the needle 26 via tube 28.
  • angiogenic drugs to the endocardium, via catheter, will require the same precise positioning of the catheter tip as in percutaneous laser revascularization techniques of the '843 patent and the Schneider application.
  • the present invention uses an angiogenic drug, instead of a channel creating laser, for revascularization.
  • angiogenic drug instead of a channel creating laser, for revascularization.
  • the application of a drug may mean its spreading through a area significantly larger than the needle induced hole in the heart wall, the ability to locate the catheter tip becomes more critical than in the laser situation of the Schneider application and the '843 patent.
  • the combination of drug delivery catheter used with the tracking system will allow the precise targeting of ischemic areas.
  • Drug delivery can take several forms. The most straightforward is the catheter 10 with needle 26.
  • the needle 26 projects either from the end of the catheter or is sheathed in some manner to prevent accidental drug delivery.
  • the catheter tip would be placed against the heart wall (using the positioning and position-sensing or tracking techniques of the incorporated by reference application and patents) .
  • Needle control 30 slides tube 28 and, in turn, moves the needle 26 from its FIG. 1 position to its extended FIG. 2 position.
  • the catheter tip would then be moved to the next location, using the tracking system (i.e., position sensing) for precise positioning, and the process repeated.
  • the drug delivery lumen within tube 28 of the catheter is preferable very small as the cost of any angiogenic drug is likely to be very high. This would reduce the amount of drug needed to fill the lumen prior to injection.
  • FIG. 4 An alternative technique to simple injection of the drug is shown schematically in FIG. 4.
  • a metallic raicro- stent device 34 coated with a drug or drugs could be implanted.
  • the drugs could be antithrombic (something like heparin that is known to aid in endotheliazation and antipoliferation) and an angiogenic drug. This would have the advantage of creating a channel that would stay open due to the antithrombic drug and would spur local vessel growth due to the angiogenic drug.
  • Approximately ten or so of these micro-stents (only 3 shown in FIG. 4, with one already mostly out of needle 26) could be preloaded in the lumen of the catheter.
  • the catheter tip would be placed against the heart wall, a needle or the like would cause a cut in the endocardium and the micro- stent would be ejected into the tissue by pushing on the proximal end of a pusher wire 36. It would expand to form a channel.
  • the expanded dimensions may be on the order of 1.5mm OD, 1mm ID and 4mm length.
  • FIG. 5 yet another alternative uses the catheter 10 and pusher wire 36 to insert implants 42 into a patient's heart wall 40.
  • the implants 42 may be stents 34 or biodegradable plugs as discussed above with an additional feature.
  • the implants have a sharp end such that they have a needle built into them.
  • the catheter for the above applications would have the same operating characteristics as the catheter of the '843 patent. It must be able to reach target areas of the left ventricle. Therefore it would have a deflectable tip (steerable) and may have the tip extension feature of that patent.
  • the catheter tip would contain the tracking system coil so that the tip could be precisely tracked and positioned. It may also contain a electrode on the tip to insure that firm contact is being made with the wall of the ventricle.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne un système médical et un procédé correspondant, pour la délivrance de médicaments angiogéniques dans le coeur d'un patient. Le système comporte un cathéter interne pour la délivrance de médicaments (14) et une aiguille (26) à positions rétractée et déployée. Le cathéter comporte une extrémité distale mise en place à l'aide d'un système de transducteurs de localisation (16, 18) dans le cathéter, et de transducteurs (24) externes au patient. Un ressort (22) dans un cathéter externe (12) stabilise le cathéter interne (10) dans le coeur du patient, et le cathéter interne (10) peut coulisser par rapport au cathéter externe (12). L'aiguille (26) est déployée hors du boîtier pour cibler avec précision la délivrance des médicaments angiogéniques sur les tissus ischémiques.
PCT/US1999/022676 1999-09-30 1999-09-30 Catheter pour la delivrance de medicaments Ceased WO2001024851A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/US1999/022676 WO2001024851A1 (fr) 1999-09-30 1999-09-30 Catheter pour la delivrance de medicaments
AU65033/99A AU6503399A (en) 1999-09-30 1999-09-30 Drug delivery catheter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1999/022676 WO2001024851A1 (fr) 1999-09-30 1999-09-30 Catheter pour la delivrance de medicaments

Publications (1)

Publication Number Publication Date
WO2001024851A1 true WO2001024851A1 (fr) 2001-04-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022676 Ceased WO2001024851A1 (fr) 1999-09-30 1999-09-30 Catheter pour la delivrance de medicaments

Country Status (2)

Country Link
AU (1) AU6503399A (fr)
WO (1) WO2001024851A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6595979B1 (en) 2001-07-10 2003-07-22 Myocardial Therapeutics, Inc. Methods for sterile aspiration/reinjection of bodily fluid
US6796957B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Sterile aspiration/reinjection systems
US6796963B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Flexible tissue injection catheters with controlled depth penetration
US6835193B2 (en) 2001-07-10 2004-12-28 Myocardial Therapeutics, Inc. Methods for controlled depth injections into interior body cavities
US9008761B2 (en) 2010-02-01 2015-04-14 Proteus Digital Health, Inc. Two-wrist data gathering system
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5458584A (en) * 1992-11-13 1995-10-17 Cardiovascular Imaging Systems, Inc. Intravascular catheter having an enclosed proximal end and a reduced profile distal region
US5484416A (en) * 1993-08-05 1996-01-16 Advanced Cardiovascular Systems, Inc. Coaxial cable vascular access system for use in various needles
US5558635A (en) * 1994-12-06 1996-09-24 Medtronic, Inc. Exchangeable guide system
US5562608A (en) * 1989-08-28 1996-10-08 Biopulmonics, Inc. Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5769843A (en) * 1996-02-20 1998-06-23 Cormedica Percutaneous endomyocardial revascularization
US5782824A (en) * 1993-09-20 1998-07-21 Abela Laser Systems, Inc. Cardiac catheter anchoring
US5916192A (en) * 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5562608A (en) * 1989-08-28 1996-10-08 Biopulmonics, Inc. Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5916192A (en) * 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use
US5458584A (en) * 1992-11-13 1995-10-17 Cardiovascular Imaging Systems, Inc. Intravascular catheter having an enclosed proximal end and a reduced profile distal region
US5484416A (en) * 1993-08-05 1996-01-16 Advanced Cardiovascular Systems, Inc. Coaxial cable vascular access system for use in various needles
US5782824A (en) * 1993-09-20 1998-07-21 Abela Laser Systems, Inc. Cardiac catheter anchoring
US5558635A (en) * 1994-12-06 1996-09-24 Medtronic, Inc. Exchangeable guide system
US5769843A (en) * 1996-02-20 1998-06-23 Cormedica Percutaneous endomyocardial revascularization

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6595979B1 (en) 2001-07-10 2003-07-22 Myocardial Therapeutics, Inc. Methods for sterile aspiration/reinjection of bodily fluid
US6796957B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Sterile aspiration/reinjection systems
US6796963B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Flexible tissue injection catheters with controlled depth penetration
US6835193B2 (en) 2001-07-10 2004-12-28 Myocardial Therapeutics, Inc. Methods for controlled depth injections into interior body cavities
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US9008761B2 (en) 2010-02-01 2015-04-14 Proteus Digital Health, Inc. Two-wrist data gathering system
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system
US10376218B2 (en) 2010-02-01 2019-08-13 Proteus Digital Health, Inc. Data gathering system

Also Published As

Publication number Publication date
AU6503399A (en) 2001-05-10

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