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WO2001018169A3 - Agents et compositions et procedes utilisant lesdits agents et lesdites compositions pour le diagnostic et/ou le traitement ou la prevention des maladies formant des plaques. - Google Patents

Agents et compositions et procedes utilisant lesdits agents et lesdites compositions pour le diagnostic et/ou le traitement ou la prevention des maladies formant des plaques. Download PDF

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Publication number
WO2001018169A3
WO2001018169A3 PCT/IL2000/000518 IL0000518W WO0118169A3 WO 2001018169 A3 WO2001018169 A3 WO 2001018169A3 IL 0000518 W IL0000518 W IL 0000518W WO 0118169 A3 WO0118169 A3 WO 0118169A3
Authority
WO
WIPO (PCT)
Prior art keywords
plaque forming
agents
forming diseases
compositions
diagnostic
Prior art date
Application number
PCT/IL2000/000518
Other languages
English (en)
Other versions
WO2001018169A2 (fr
Inventor
Beka Solomon
Dan Frenkel
Eilat Hanan
Original Assignee
Univ Ramot
Beka Solomon
Dan Frenkel
Eilat Hanan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/473,653 external-priority patent/US6703015B1/en
Priority to HK02106123.5A priority Critical patent/HK1044564B/en
Priority to JP2001522381A priority patent/JP2003509020A/ja
Priority to US09/830,954 priority patent/US6919075B1/en
Priority to IL14294800A priority patent/IL142948A0/xx
Priority to DE60044057T priority patent/DE60044057D1/de
Application filed by Univ Ramot, Beka Solomon, Dan Frenkel, Eilat Hanan filed Critical Univ Ramot
Priority to CA002349434A priority patent/CA2349434A1/fr
Priority to AT00954883T priority patent/ATE461996T1/de
Priority to AU67232/00A priority patent/AU784568B2/en
Priority to EP00954883A priority patent/EP1180938B1/fr
Publication of WO2001018169A2 publication Critical patent/WO2001018169A2/fr
Priority to IL142948A priority patent/IL142948A/en
Publication of WO2001018169A3 publication Critical patent/WO2001018169A3/fr
Priority to US11/073,526 priority patent/US20050152878A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)

Abstract

La présente invention concerne un procédé d'immunisation contre les maladies formant des plaques, au moyen d'une technique d'affichage. Ce procédé consiste à utiliser de nouveaux agents, ou des compositions pharmaceutiques servant à la vaccination contre les maladies formant des plaques, et à présenter un antigène ou un épitope sur un support d'affichage. Ledit procédé consiste en outre à utiliser des agents, ou des compositions pharmaceutiques pour la vaccination contre les maladies formant des plaques, et à présenter un anticorps, ou une portion active de cet anticorps, sur un support d'affichage. Qu'il s'agisse d'antigènes ou d'anticorps, la désagrégation des plaques résulte de l'immunisation.
PCT/IL2000/000518 1999-09-03 2000-08-31 Agents et compositions et procedes utilisant lesdits agents et lesdites compositions pour le diagnostic et/ou le traitement ou la prevention des maladies formant des plaques. WO2001018169A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP00954883A EP1180938B1 (fr) 1999-09-03 2000-08-31 Agents, compositions et procedes utilisant lesdits agents et lesdites compositions pour le traitement ou la prevention de la maladie d'alzheimer
AT00954883T ATE461996T1 (de) 1999-09-03 2000-08-31 Verbindungen, zusammensetzungen und verfahren zur behandlung oder vorsorge von alzheimer erkrankung
US09/830,954 US6919075B1 (en) 1999-09-03 2000-08-31 Bacteriophage displaying aβ epitopes and method of use
IL14294800A IL142948A0 (en) 1999-09-03 2000-08-31 Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
DE60044057T DE60044057D1 (de) 1999-09-03 2000-08-31 Verbindungen, zusammensetzungen und verfahren zur behandlung oder vorsorge von alzheimer erkrankung
HK02106123.5A HK1044564B (en) 1999-09-03 2000-08-31 Agents, compositions and methods utilizing the same useful in treating or preventing alzheimer disease
CA002349434A CA2349434A1 (fr) 1999-09-03 2000-08-31 Agents et compositions et procedes utilisant lesdits agents et lesdites compositions pour le diagnostic et/ou le traitement ou la prevention des maladies formant des plaques.
JP2001522381A JP2003509020A (ja) 1999-09-03 2000-08-31 プラーク形成疾患の診断、治療、予防に有用な薬剤、組成物、その使用法
AU67232/00A AU784568B2 (en) 1999-09-03 2000-08-31 Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
IL142948A IL142948A (en) 1999-09-03 2001-05-03 Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
US11/073,526 US20050152878A1 (en) 1999-09-03 2005-03-08 Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15241799P 1999-09-03 1999-09-03
US60/152,417 1999-09-03
US09/473,653 1999-12-29
US09/473,653 US6703015B1 (en) 1999-09-03 1999-12-29 Filamentous bacteriophage displaying an β-amyloid epitope
US62997100A 2000-07-31 2000-07-31
US09/629,971 2000-07-31

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US09/473,653 Continuation-In-Part US6703015B1 (en) 1997-10-17 1999-12-29 Filamentous bacteriophage displaying an β-amyloid epitope
US62997100A Continuation 1997-10-17 2000-07-31

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09/830,954 A-371-Of-International US6919075B1 (en) 1999-09-03 2000-08-31 Bacteriophage displaying aβ epitopes and method of use
US10/384,788 Continuation-In-Part US20040013647A1 (en) 1999-09-03 2003-03-11 Methods and compositions for treating a plaque-forming disease
US11/073,526 Continuation US20050152878A1 (en) 1999-09-03 2005-03-08 Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases

Publications (2)

Publication Number Publication Date
WO2001018169A2 WO2001018169A2 (fr) 2001-03-15
WO2001018169A3 true WO2001018169A3 (fr) 2001-11-22

Family

ID=27387248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2000/000518 WO2001018169A2 (fr) 1999-09-03 2000-08-31 Agents et compositions et procedes utilisant lesdits agents et lesdites compositions pour le diagnostic et/ou le traitement ou la prevention des maladies formant des plaques.

Country Status (11)

Country Link
US (4) US6919075B1 (fr)
EP (1) EP1180938B1 (fr)
JP (1) JP2003509020A (fr)
AT (1) ATE461996T1 (fr)
AU (1) AU784568B2 (fr)
CA (1) CA2349434A1 (fr)
DE (1) DE60044057D1 (fr)
ES (1) ES2344189T3 (fr)
HK (1) HK1044564B (fr)
IL (1) IL142948A0 (fr)
WO (1) WO2001018169A2 (fr)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US6946135B2 (en) 1997-12-02 2005-09-20 Neuralab Limited Prevention and treatment of amyloidogenic disease
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US7189819B2 (en) 2000-12-06 2007-03-13 Wyeth Humanized antibodies that recognize beta amyloid peptide
US7256273B2 (en) 2002-03-12 2007-08-14 Elan Pharma International Limited Humanized antibodies that recognize beta amyloid peptide
US7575880B1 (en) 2000-05-26 2009-08-18 Elan Pharma International Limited Method of screening an antibody for activity in clearing an amyloid deposit
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7625560B2 (en) 2004-12-15 2009-12-01 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7871615B2 (en) 2003-05-30 2011-01-18 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7893214B2 (en) 1997-12-02 2011-02-22 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
US8613920B2 (en) 2007-07-27 2013-12-24 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8916165B2 (en) 2004-12-15 2014-12-23 Janssen Alzheimer Immunotherapy Humanized Aβ antibodies for use in improving cognition
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
US9580493B2 (en) 2011-06-23 2017-02-28 Biogen International Neuroscience Gmbh Anti-α synuclein binding molecules
US9644025B2 (en) 2007-10-17 2017-05-09 Wyeth Llc Immunotherapy regimes dependent on ApoE status

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787523B1 (en) * 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US20050059802A1 (en) * 1998-04-07 2005-03-17 Neuralab Ltd Prevention and treatment of amyloidogenic disease
US20020052311A1 (en) * 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
WO2001062801A2 (fr) 2000-02-24 2001-08-30 Washington University Anticorps humanises sequestrant un peptide a$g(b)
JP2003516929A (ja) * 2000-06-01 2003-05-20 ニユーララブ・リミテツド アミロイド形成性疾患の予防および治療
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
ES2437875T3 (es) 2001-04-30 2014-01-14 Eli Lilly And Company Anticuerpos humanizados que reconocen el péptido beta-amiloide
WO2002088307A2 (fr) 2001-04-30 2002-11-07 Eli Lilly And Company Anticorps humanises
US6906169B2 (en) 2001-05-25 2005-06-14 United Biomedical, Inc. Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide
PT1944040E (pt) 2001-08-17 2012-10-31 Univ Washington Método de avaliação para a doença de alzheimer
AU2003225636A1 (en) * 2002-03-05 2003-09-22 Ramot At Tel-Aviv University Ltd. Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein
MXPA05000819A (es) 2002-07-19 2005-08-29 Cytos Biotechnology Ag Composiciones de vacunas que contienen arreglos de antigeno amiloide beta 1-6.
AT413945B (de) * 2003-01-14 2006-07-15 Mattner Frank Dr Impfstoff für die alzheimer-krankheit
AU2004209981B2 (en) * 2003-02-01 2009-02-26 Janssen Sciences Ireland Uc Active immunization to generate antibodies to soluble A-beta
EP1596809B1 (fr) 2003-02-10 2010-05-26 Applied Molecular Evolution, Inc. Molecules de liaison au peptide abeta
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US7807171B2 (en) 2003-07-25 2010-10-05 Ac Immune Sa Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
US20050225165A1 (en) * 2004-04-13 2005-10-13 Naik Sanjeev M Brake by-wire control system
WO2006004749A2 (fr) * 2004-06-25 2006-01-12 Id Biomedical Corporation Of Quebec Compositions et procedes de traitement de troubles neurologiques
AT413946B (de) 2004-07-13 2006-07-15 Mattner Frank Dr Impfstoff gegen die alzheimer-krankheit
AU2005272396A1 (en) * 2004-08-11 2006-02-16 Mitsubishi Chemical Corporation Antibody and utilization of the same
EP1792911A4 (fr) * 2004-09-15 2008-09-17 Univ Yokohama City Sequence d'acides amines essentielle pour l'expression de genes neurospecifiques
WO2006047670A2 (fr) * 2004-10-26 2006-05-04 Wyeth Procedes permettant d'evaluer les anticorps diriges contre des antigenes associes aux maladies neurodegeneratives
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
PT1853285E (pt) * 2005-02-01 2011-06-06 Univ Ramot Método para tratamento de inflamação associada a depósitos de amilóide e inflamação cerebral envolvendo microglia activada
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
BRPI0619748B8 (pt) * 2005-12-12 2021-05-25 Ac Immune Sa anticorpo monoclonal, polinucleotídeo, composição, mistura, uso de um anticorpo monoclonal ou uma parte funcional do mesmo, método para preparar uma composição farmacêutica, linhagem celular de hibridoma isolado, método de diagnóstico de uma doença ou condição associada a amilóide em um paciente, método para diagnosticar uma predisposição para uma doença ou condição, método para monitorar doença residual mínima, método para prever a responsividade de um paciente e kits de teste
EP1991259B1 (fr) * 2006-02-15 2012-10-10 Ramot at Tel-Aviv University Ltd. Véhicules d'affichage de virus pour traiter la sclérose en plaques
WO2008011348A2 (fr) 2006-07-14 2008-01-24 Ac Immune S.A. Anticorps humanisé
ATE541038T1 (de) * 2006-07-21 2012-01-15 Univ Ramot Verwendung eines phagen mit anzeige eines peptids eines adhäsionsproteins zur behandlung einer erkrankung im zusammenhang mit intrazellulärer bildung von fibrillären proteineinschlüssen oder aggregraten
US20100129354A1 (en) * 2006-10-27 2010-05-27 Ablynx N.V. Intranasal delivery of polypeptides and proteins
LT2436696T (lt) 2007-01-05 2017-08-25 University Of Zurich Anti-beta-amiloido antikūnas ir jo panaudojimas
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
KR101160385B1 (ko) 2007-01-18 2012-07-10 일라이 릴리 앤드 캄파니 페길화된 Ａβ ＦＡＢ
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
ME01026B (fr) * 2007-11-16 2012-10-20 Univ Rockefeller Anticorps spécifiques de la forme de protofibrille de protéine bêta-amyloïde
ITNA20080006A1 (it) * 2008-01-28 2009-07-29 Consiglio Nazionale Ricerche Proteine chimeriche capaci di formare particelle virus-like, che contengono sequenze peptidiche del beta-amiloide e la componente e2 della alfachetoacido deidrogenasi di "geobacillus stearothermophilus", utili per l'induzione di una risposta anticorp
CA2730073A1 (fr) * 2008-07-09 2010-01-14 University Of Zurich Procede d'activation de la neurogenese
CN102223887B (zh) * 2008-11-24 2013-11-06 台拉维夫大学拉莫特 使用丝状噬菌体治疗帕金森病的方法
DK2949666T3 (en) 2008-12-19 2019-03-25 Biogen Int Neuroscience Gmbh HUMAN ANTI-ALPHA SYNUCLEIN ANTIBODIES
JP5905457B2 (ja) * 2010-07-02 2016-04-20 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 尿路感染症（ｕｔｉ）ワクチン
EP2603233A1 (fr) 2010-08-12 2013-06-19 AC Immune S.A. Vaccin obtenu par génie génétique
EP3533803B1 (fr) 2010-08-14 2021-10-27 AbbVie Inc. Anticorps anti-bêta-amyloïde
KR101854943B1 (ko) 2010-10-26 2018-05-04 에이씨 이뮨 에스.에이. 소수성 부분을 통해 변형된 펩티드를 포함하는 리포솜 기반 구조체
US8877446B2 (en) * 2011-08-26 2014-11-04 Korea Research Institute Of Bioscience And Biotechnology Method for detecting protein-protein interactions in cells
JP2012102131A (ja) * 2012-01-05 2012-05-31 Elan Pharma Internatl Ltd アミロイド形成性疾患の予防および治療
JP6077570B2 (ja) * 2012-12-27 2017-02-08 Ｓｐｉｂｅｒ株式会社 親水性組換えタンパク質の粗精製方法
CN104884463B (zh) * 2012-12-27 2018-09-18 丝芭博株式会社 亲水性重组蛋白的提取方法
CA2907234A1 (fr) 2013-03-15 2014-09-25 Altria Client Services Llc Bacteriophage et ses procedes de fabrication et d'utilisation
US9102752B2 (en) 2013-03-15 2015-08-11 United Biomedical, Inc. Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type
EP2990062B1 (fr) 2013-04-25 2021-11-10 Spiber Inc. Hydrogel de polypeptide et son procédé de production
US10065997B2 (en) 2013-04-25 2018-09-04 Spiber Inc. Polypeptide porous body and method for producing same
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
WO2016123425A1 (fr) 2015-01-29 2016-08-04 Altria Client Services Llc Endolysine issue des bactériophages dirigés contre geobacillus et procédés d'utilisation associés
WO2016123427A1 (fr) 2015-01-29 2016-08-04 Altria Client Services Llc Bactériophages et procédés d'utilisation correspondants
US12227567B2 (en) 2017-07-25 2025-02-18 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
IL272773B2 (en) 2017-08-22 2024-06-01 Biogen Ma Inc Pharmaceutical compositions containing anti-beta amyloid antibodies
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811093A (en) * 1994-04-05 1998-09-22 Exponential Biotherapies, Inc. Bacteriophage genotypically modified to delay inactivations by the host defense system

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022190D0 (en) 1990-10-12 1990-11-28 Perham Richard N Immunogenic material
US5688651A (en) * 1994-12-16 1997-11-18 Ramot University Authority For Applied Research And Development Ltd. Prevention of protein aggregation
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
US5846533A (en) * 1995-09-14 1998-12-08 The Regents Of The University Of California Antibodies specific for native PrPSc
GB9626675D0 (en) * 1996-12-23 1997-02-12 Procter & Gamble Hair coloring compositions
US6703015B1 (en) * 1999-09-03 2004-03-09 Ramot At Tel-Aviv University Ltd. Filamentous bacteriophage displaying an β-amyloid epitope
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US6743427B1 (en) * 1997-12-02 2004-06-01 Neuralab Limited Prevention and treatment of amyloidogenic disease
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
US20020140675A1 (en) * 1999-01-25 2002-10-03 Ali Ammar Al System and method for altering a display mode based on a gravity-responsive sensor
AU6722300A (en) * 1999-08-31 2001-03-26 Ramot University Authority For Applied Research And Industrial Development Ltd. Peptides and substances, methods and devices using same for diagnosing and treating neurodegenerative disorders
US20020052311A1 (en) * 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
US20040013647A1 (en) * 1999-09-03 2004-01-22 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating a plaque-forming disease
US6597384B1 (en) * 1999-12-22 2003-07-22 Intel Corporation Automatic reorienting of screen orientation using touch sensitive system
US6621508B1 (en) * 2000-01-18 2003-09-16 Seiko Epson Corporation Information processing system
US20030148404A1 (en) * 2000-07-27 2003-08-07 Ramot University Authority For Applied Research & Industrial Development Ltd. Peptides and substances, methods and devices using same for diagnosing and treating neurodegenerative disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811093A (en) * 1994-04-05 1998-09-22 Exponential Biotherapies, Inc. Bacteriophage genotypically modified to delay inactivations by the host defense system

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DELMASTRO P. ET AL.: "Immunogenicity of Filamentous Phage Displaying Peptide Mimotopes after oral administration", VACCINE, vol. 15, no. 11, 1997, pages 1276 - 1285, XP002942846 *
FRENKEL D. ET AL.: "N-terminal EFRH sequence of Alzheimer's beta-amyloid peptide represents the epitope of its anti-aggregating antibodies", JOURNAL OF NEUROIMMUNOLOGY, vol. 88, 1998, pages 85 - 90, XP002942851 *
HANAN E. ET AL.: "Inhibitory Effect of Monoclonla Antibodies on Alzheimer's beta-Amyloid Petide Aggregation", AMYLOID: INT. J. EXP. CLIN. INVEST., vol. 3, 1996, pages 131 - 132, XP002942848 *
MOTTI C.: "Recognition by Human Sera and Immunogenicity of HBsAg Minitopes Selected from an M13 Phage Display Library", GENE, vol. 146, 1994, pages 191 - 198, XP002942847 *
SCHENK D. ET AL.: "Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPP mouse", NATURE, vol. 8, July 1999 (1999-07-01), pages 173 - 177, XP002942852 *
SOLOMON B. ET AL.: "Disaggregation of Alzheimer beta-Amyloid by Site-Directed mAb", PROC. NATL. ACAD. SCI. USA, vol. 94, April 1997 (1997-04-01), pages 4109 - 4112, XP002942849 *
SOLOMON B. ET AL.: "Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide", PROC. NATL. ACAD. SCI. USA, vol. 93, January 1996 (1996-01-01), pages 452 - 455, XP002942850 *
SOMERVILLE R. A. ET AL.: "Immunodetection of PrPsc in spleens of some scrapie-infected sheep bot BSE-infected cows", JOURNAL OF GENERAL VIROLOGY, vol. 78, 1997, pages 2389 - 2396, XP002942853 *

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US9051363B2 (en) 1997-12-02 2015-06-09 Janssen Sciences Ireland Uc Humanized antibodies that recognize beta amyloid peptide
US6946135B2 (en) 1997-12-02 2005-09-20 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6972127B2 (en) 1997-12-02 2005-12-06 Neuralab Limited Prevention and treatment of amyloidogenic disease
US8034339B2 (en) 1997-12-02 2011-10-11 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US8535673B2 (en) 1997-12-02 2013-09-17 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US8642044B2 (en) 1997-12-02 2014-02-04 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US7893214B2 (en) 1997-12-02 2011-02-22 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US8034348B2 (en) 1997-12-02 2011-10-11 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7582733B2 (en) 1998-11-30 2009-09-01 Elan Pharma International Limited Humanized antibodies that recognize beta amyloid peptide
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7575880B1 (en) 2000-05-26 2009-08-18 Elan Pharma International Limited Method of screening an antibody for activity in clearing an amyloid deposit
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US7189819B2 (en) 2000-12-06 2007-03-13 Wyeth Humanized antibodies that recognize beta amyloid peptide
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US7256273B2 (en) 2002-03-12 2007-08-14 Elan Pharma International Limited Humanized antibodies that recognize beta amyloid peptide
US8128928B2 (en) 2002-03-12 2012-03-06 Wyeth Llc Humanized antibodies that recognize beta amyloid peptide
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US7871615B2 (en) 2003-05-30 2011-01-18 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7625560B2 (en) 2004-12-15 2009-12-01 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US8916165B2 (en) 2004-12-15 2014-12-23 Janssen Alzheimer Immunotherapy Humanized Aβ antibodies for use in improving cognition
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US8613920B2 (en) 2007-07-27 2013-12-24 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
US9644025B2 (en) 2007-10-17 2017-05-09 Wyeth Llc Immunotherapy regimes dependent on ApoE status
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
US9580493B2 (en) 2011-06-23 2017-02-28 Biogen International Neuroscience Gmbh Anti-α synuclein binding molecules

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US20050152878A1 (en) 2005-07-14
ATE461996T1 (de) 2010-04-15
US20050089510A1 (en) 2005-04-28
AU784568B2 (en) 2006-05-04
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US20030077252A1 (en) 2003-04-24
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EP1180938B1 (fr) 2010-03-24
IL142948A0 (en) 2002-04-21
US6919075B1 (en) 2005-07-19
HK1044564A1 (en) 2002-10-25
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JP2003509020A (ja) 2003-03-11
EP1180938A2 (fr) 2002-02-27
CA2349434A1 (fr) 2001-03-15

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