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WO2001015738A3 - Materiaux hydrogels produisant du monoxyde d'azote - Google Patents

Materiaux hydrogels produisant du monoxyde d'azote Download PDF

Info

Publication number
WO2001015738A3
WO2001015738A3 PCT/US2000/024058 US0024058W WO0115738A3 WO 2001015738 A3 WO2001015738 A3 WO 2001015738A3 US 0024058 W US0024058 W US 0024058W WO 0115738 A3 WO0115738 A3 WO 0115738A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogels
macromers
released
treatment
releasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/024058
Other languages
English (en)
Other versions
WO2001015738A2 (fr
Inventor
Jennifer L Hill-West
Kristyn Simcha Bohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Priority to EP00959750A priority Critical patent/EP1194171A2/fr
Priority to IL14330500A priority patent/IL143305A0/xx
Priority to AU71016/00A priority patent/AU7101600A/en
Priority to MXPA01005338A priority patent/MXPA01005338A/es
Priority to CA002353531A priority patent/CA2353531A1/fr
Publication of WO2001015738A2 publication Critical patent/WO2001015738A2/fr
Publication of WO2001015738A3 publication Critical patent/WO2001015738A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)

Abstract

L'invention concerne des hydrogels produisant du monoxyde d'azote (NO), de préférence photopolymérisables et biodégradables, pouvant libérer des quantités physiologiques de NO sur une durée prolongée, que l'on applique sur des sites ou à un patient nécessitant l'application de ce type de matériau pour le traitement de troubles comme la resténose, la thrombose, l'asthme, la cicatrisation, l'arthrite, la dysérection ou autres, dans lesquels le NO joue un rôle important. En règle générale, les hydrogels sont constitués de macromères, qui comprennent de préférence des zones biodégradables, et des groupes liés aux macromères sont libérés in situ, élevant ou modulant les niveaux de NO là où le traitement est requis. Les macromères peuvent former une homo ou hétéro-dispersion ou solution, polymérisée de manière à donner un matériau hydrogel qui, dans le dernier cas, peut être un réseau à semi-interpénétration ou à interpénétration. Les composés destinés à être libérés peuvent être physiquement emprisonnés, liés de façon covalente ou ionique au macromère, ou faire partie intégrante du matériau polymère. L'hydrogel peut être formé par réticulation ionique et/ou covalente. D'autres agents actifs (par exemple, thérapeutiques, prophylactiques ou diagnostiques) peuvent également être incorporés au matériau polymère.
PCT/US2000/024058 1999-09-02 2000-09-01 Materiaux hydrogels produisant du monoxyde d'azote Ceased WO2001015738A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP00959750A EP1194171A2 (fr) 1999-09-02 2000-09-01 Materiaux hydrogels produisant du monoxyde d'azote
IL14330500A IL143305A0 (en) 1999-09-02 2000-09-01 Nitric oxide-producing hydrogel materials
AU71016/00A AU7101600A (en) 1999-09-02 2000-09-01 Nitric oxide-producing hydrogel materials
MXPA01005338A MXPA01005338A (es) 1999-09-02 2000-09-01 Materiales de hidrogel para la produccion de oxido nitrico.
CA002353531A CA2353531A1 (fr) 1999-09-02 2000-09-01 Materiaux hydrogels produisant du monoxyde d'azote

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15205499P 1999-09-02 1999-09-02
US60/152,054 1999-09-02

Publications (2)

Publication Number Publication Date
WO2001015738A2 WO2001015738A2 (fr) 2001-03-08
WO2001015738A3 true WO2001015738A3 (fr) 2002-01-31

Family

ID=22541347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024058 Ceased WO2001015738A2 (fr) 1999-09-02 2000-09-01 Materiaux hydrogels produisant du monoxyde d'azote

Country Status (7)

Country Link
EP (1) EP1194171A2 (fr)
AU (1) AU7101600A (fr)
CA (1) CA2353531A1 (fr)
CZ (1) CZ20011899A3 (fr)
IL (1) IL143305A0 (fr)
MX (1) MXPA01005338A (fr)
WO (1) WO2001015738A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US9919072B2 (en) 2009-08-21 2018-03-20 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7052711B2 (en) 1999-09-02 2006-05-30 Rice University Nitric oxide-producing hydrogel materials
US7279176B1 (en) 1999-09-02 2007-10-09 Rice University Nitric oxide-producing hydrogel materials
AU2001263281A1 (en) * 2000-05-18 2001-11-26 Genetix Pharmaceuticals, Inc. Polyethylene glycol (peg) polymers for the promotion of angiogenesis
JP4841066B2 (ja) * 2000-09-01 2011-12-21 ライスユニバーシティ 酸化窒素生成ヒドロゲル物質
US7040313B2 (en) 2001-09-05 2006-05-09 Cyterra Corporation Method and apparatus for nitric oxide generation
EP1503768B1 (fr) 2002-04-29 2015-10-28 NormOxys, Inc. Inositol pyrophosphates et utilisation desdits composés
CA2487720A1 (fr) * 2002-06-03 2003-12-11 Alnis Biosciences, Inc. Agent therapeutique contenant des nanoarticles polymeriques
US7618594B2 (en) 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
US7560076B2 (en) 2004-08-18 2009-07-14 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
CA2681308C (fr) 2007-03-23 2015-11-24 Geno Llc Conversion du dioxyde d'azote (no<sb>2</sb>) en oxyde nitrique (no)
AU2009209181B2 (en) 2008-01-28 2014-01-16 VERO Biotech LLC. Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
US8607785B2 (en) 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
EP2445508B1 (fr) 2009-06-22 2018-11-14 VERO Biotech LLC Thérapies par oxyde nitrique
WO2011063335A1 (fr) 2009-11-20 2011-05-26 Geno Llc Système de distribution d'oxyde nitrique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032136A1 (fr) * 1995-04-10 1996-10-17 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Produits d'addition bioxyde d'azote-nucleophiles lies a des polysaccharides
US5910316A (en) * 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
HUP9801673A1 (hu) * 1998-07-24 2000-08-28 CYCLOLAB, Ciklodextrin Kutató-Fejlesztő Kft. Helyi vérbőséget fokozó gyógyszerkészítmények előállítása és alkalmazása

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5797887A (en) * 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910316A (en) * 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
WO1996032136A1 (fr) * 1995-04-10 1996-10-17 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Produits d'addition bioxyde d'azote-nucleophiles lies a des polysaccharides
HUP9801673A1 (hu) * 1998-07-24 2000-08-28 CYCLOLAB, Ciklodextrin Kutató-Fejlesztő Kft. Helyi vérbőséget fokozó gyógyszerkészítmények előállítása és alkalmazása

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOHL, K. ET AL: "Nitric oxide producing materials: a potential therapy for thrombosis and restenosis", PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER. (1999), 26TH, 56-57, XP001009872 *
BOHL, K. S. ET AL: "Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation", BIOMATERIALS (2000), 21(22), 2273-2278, XP004210284 *
BOHL, K. S. ET AL: "Nitric oxide-releasing materials for the prevention of thrombosis and restenosis", PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER. (2000), 27TH, 143-144, XP001009803 *
D.J. SMITH ET AL.: "Nitric Oxide-Releasing Polymers Containing the [N(O)NO]- Group", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1996, WASHINGTON US, pages 1148 - 1156, XP002172759 *
DATABASE WPI Section Ch Week 200061, Derwent World Patents Index; Class B05, AN 2000-630208, XP002172760 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9403852B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8956658B2 (en) 2005-05-27 2015-02-17 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8962029B2 (en) 2005-05-27 2015-02-24 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US11691995B2 (en) 2005-05-27 2023-07-04 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9403851B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9919072B2 (en) 2009-08-21 2018-03-20 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
US11583608B2 (en) 2009-08-21 2023-02-21 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
US9737561B2 (en) 2009-08-21 2017-08-22 Novan, Inc. Topical gels and methods of using the same
US10376538B2 (en) 2009-08-21 2019-08-13 Novan, Inc. Topical gels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US9713652B2 (en) 2011-02-28 2017-07-25 The University Of North Carolina At Chapel Hill Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same

Also Published As

Publication number Publication date
EP1194171A2 (fr) 2002-04-10
CZ20011899A3 (cs) 2001-11-14
MXPA01005338A (es) 2003-07-14
WO2001015738A2 (fr) 2001-03-08
AU7101600A (en) 2001-03-26
IL143305A0 (en) 2002-04-21
CA2353531A1 (fr) 2001-03-08

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