[go: up one dir, main page]

WO2001006226A3 - Methods for determining the proliferation activity of cells - Google Patents

Methods for determining the proliferation activity of cells Download PDF

Info

Publication number
WO2001006226A3
WO2001006226A3 PCT/EP2000/006656 EP0006656W WO0106226A3 WO 2001006226 A3 WO2001006226 A3 WO 2001006226A3 EP 0006656 W EP0006656 W EP 0006656W WO 0106226 A3 WO0106226 A3 WO 0106226A3
Authority
WO
WIPO (PCT)
Prior art keywords
determining
methods
cells
proliferation activity
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/006656
Other languages
German (de)
French (fr)
Other versions
WO2001006226A2 (en
Inventor
Oliver Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority to AU68230/00A priority Critical patent/AU6823000A/en
Publication of WO2001006226A2 publication Critical patent/WO2001006226A2/en
Publication of WO2001006226A3 publication Critical patent/WO2001006226A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to methods for determining the proliferation activity of cells by analyzing the concentration and/or the sub-cellular localization of the APC protein in samples and optionally, also determining the functionality of the APC protein. The invention also relates to antibodies, nucleic acids and kits for carrying out the inventive methods.
PCT/EP2000/006656 1999-07-15 2000-07-12 Methods for determining the proliferation activity of cells Ceased WO2001006226A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68230/00A AU6823000A (en) 1999-07-15 2000-07-12 Methods for determining the proliferation activity of cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19933237.1 1999-07-15
DE1999133237 DE19933237A1 (en) 1999-07-15 1999-07-15 Method for determining the proliferation activity of cells

Publications (2)

Publication Number Publication Date
WO2001006226A2 WO2001006226A2 (en) 2001-01-25
WO2001006226A3 true WO2001006226A3 (en) 2001-08-02

Family

ID=7914922

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006656 Ceased WO2001006226A2 (en) 1999-07-15 2000-07-12 Methods for determining the proliferation activity of cells

Country Status (3)

Country Link
AU (1) AU6823000A (en)
DE (1) DE19933237A1 (en)
WO (1) WO2001006226A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211195B4 (en) * 2002-03-11 2009-01-02 Ipc Process Center Gmbh Dietary supplements

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013103A1 (en) * 1991-01-16 1992-08-06 The Johns Hopkins University Inherited and somatic mutations of apc gene in colorectal cancer of humans
WO1994021814A1 (en) * 1993-03-19 1994-09-29 The Johns Hopkins University Antibodies and assays for determining mutations in the apc gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013103A1 (en) * 1991-01-16 1992-08-06 The Johns Hopkins University Inherited and somatic mutations of apc gene in colorectal cancer of humans
WO1994021814A1 (en) * 1993-03-19 1994-09-29 The Johns Hopkins University Antibodies and assays for determining mutations in the apc gene

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DEKA J ET AL: "THE APC PROTEIN BINDS TO A/T RICH DNA SEQUENCES", ONCOGENE,GB,BASINGSTOKE, HANTS, vol. 18, no. 41, 7 October 1999 (1999-10-07), pages 5654 - 5661, XP000901010, ISSN: 0950-9232 *
DOBASHI YOH ET AL: "Upregulation of the APC gene product during neuronal differentiation of rat pheochromocytoma PC12 cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 224, no. 2, 1996, pages 479 - 483, XP000979217, ISSN: 0006-291X *
NEUFELD KRISTI L ET AL: "Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 94, no. 7, 1997, 1997, pages 3034 - 3039, XP000981747, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU6823000A (en) 2001-02-05
WO2001006226A2 (en) 2001-01-25
DE19933237A1 (en) 2001-01-18

Similar Documents

Publication Publication Date Title
WO2003022028A3 (en) Methods, reagents, kits and apparatus for protein function analysis
AU2002311773A1 (en) Labeled cells for use as an internal functional control in rare cell detection assays
WO2000001845A3 (en) Method for early diagnosis of carcinomas
WO2002084250A3 (en) Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
WO2001027624A3 (en) Compositions and methods for detecting protein modification and enzymatic activity
AU2003224674A1 (en) Compounds and methods for analyzing the proteome
CA2285918A1 (en) Methods for concentrating ligands using magnetic particles
AU6834700A (en) Device and method for determining multiple analytes
WO1998009170A3 (en) Methods and compositions for the detection of cervical cancer
WO2001036470A3 (en) Methods and compositions for detection and treatment of breast cancer, based on breast cancer-associated polypeptides
WO2004011607A3 (en) Reagent and method for determination of a substance using an immunoaggregator
WO2002024862A3 (en) Sample positioning and analysis system
WO2002048403A3 (en) Multiplexed protein expression and activity assay
WO2001044809A3 (en) Evaluation of biological agents in living target cells
EP1652918A3 (en) Methods for detecting protein interactions using conformationally constrained peptides
DE69902796D1 (en) METHOD FOR PURIFYING BIOMOLECULE OR PROTEIN COMPLEXES
WO2001069247A3 (en) Methods of making and using microarrays of anti-ligands for the analysis of protein expression in cells
WO2002090989A3 (en) Method for detecting blood cell antigens and the antibodies in response to the same
HK1040420A1 (en) Metabolic selection methods
WO2002026929A3 (en) Kini-3 motor protein and methods for its use
WO2001006226A3 (en) Methods for determining the proliferation activity of cells
AU4908799A (en) Determination of the hydrophobic pulmonary surfactant protein sp-c
WO2002077285A3 (en) Methods of determining the presence of polynucleotides employing amplification
WO1998029726A3 (en) Method of detecting and determining the concentration of total troponin i in a biological sample
WO2004094989A3 (en) Methods of host cell protein analysis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP