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WO2001006250A3 - Thermo-chemical sensors and uses thereof - Google Patents

Thermo-chemical sensors and uses thereof Download PDF

Info

Publication number
WO2001006250A3
WO2001006250A3 PCT/US2000/019383 US0019383W WO0106250A3 WO 2001006250 A3 WO2001006250 A3 WO 2001006250A3 US 0019383 W US0019383 W US 0019383W WO 0106250 A3 WO0106250 A3 WO 0106250A3
Authority
WO
WIPO (PCT)
Prior art keywords
thermo
chemical sensors
target
methods
link
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/019383
Other languages
French (fr)
Other versions
WO2001006250A2 (en
Inventor
Patrick R Connelly
Janid Asghar Ali
Frank Joseph Bruzzese
Carlos H Faerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trine Pharmaceuticals Inc
Original Assignee
Althexis Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Althexis Co Inc filed Critical Althexis Co Inc
Priority to JP2001510836A priority Critical patent/JP2003504641A/en
Priority to EP00947428A priority patent/EP1194767A2/en
Priority to AU61038/00A priority patent/AU6103800A/en
Priority to CA002380283A priority patent/CA2380283A1/en
Publication of WO2001006250A2 publication Critical patent/WO2001006250A2/en
Publication of WO2001006250A3 publication Critical patent/WO2001006250A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample

Landscapes

  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Methods described herein link the binding event of a test ligand, or a substrate, to a target (e.g., a target protein) to the generation of a heat output. Methods of the present application can be used to screen for pharmaceutical agents.
PCT/US2000/019383 1999-07-19 2000-07-18 Thermo-chemical sensors and uses thereof Ceased WO2001006250A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001510836A JP2003504641A (en) 1999-07-19 2000-07-18 Thermochemical sensors and uses thereof
EP00947428A EP1194767A2 (en) 1999-07-19 2000-07-18 Thermo-chemical sensors and uses thereof
AU61038/00A AU6103800A (en) 1999-07-19 2000-07-18 Thermo-chemical sensors and uses thereof
CA002380283A CA2380283A1 (en) 1999-07-19 2000-07-18 Thermo-chemical sensors and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14457999P 1999-07-19 1999-07-19
US60/144,579 1999-07-19
US45312299A 1999-12-02 1999-12-02
US09/453,122 1999-12-02

Publications (2)

Publication Number Publication Date
WO2001006250A2 WO2001006250A2 (en) 2001-01-25
WO2001006250A3 true WO2001006250A3 (en) 2001-04-12

Family

ID=26842132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019383 Ceased WO2001006250A2 (en) 1999-07-19 2000-07-18 Thermo-chemical sensors and uses thereof

Country Status (5)

Country Link
EP (1) EP1194767A2 (en)
JP (1) JP2003504641A (en)
AU (1) AU6103800A (en)
CA (1) CA2380283A1 (en)
WO (1) WO2001006250A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002021125A2 (en) * 2000-09-05 2002-03-14 The Althexis Company, Inc. Drug discover employing calorimetric target triage
JP2005502861A (en) * 2001-08-10 2005-01-27 サイミックス テクノロジーズ， インコーポレイテッド Apparatus and method for making and testing pre-formulations and system therefor
JP2005529158A (en) * 2002-05-28 2005-09-29 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア Method, system and computer program product for computer analysis and design of amphiphilic polymers
US7745161B2 (en) * 2003-12-19 2010-06-29 Palo Alto Research Center Incorporated Amplification of enzymatic reactions for use with an enthalpy array

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3789662A (en) * 1971-10-26 1974-02-05 Instrumentation Labor Inc Calorimetry
US4021307A (en) * 1974-06-07 1977-05-03 Lkb-Produkter Ab Method and apparatus for measuring temperature changes generated by enzyme activity
WO1990000203A1 (en) * 1988-06-27 1990-01-11 Boehringer Mannheim Corporation Improved biosensor and the method of its use
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5255976A (en) * 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
US5813763A (en) * 1996-10-11 1998-09-29 Microcal Incorporated Ultrasensitive differential microcalorimeter
WO1999034206A1 (en) * 1997-12-23 1999-07-08 Studiengesellschaft Kohle Mbh Method for combinatorial material development using differential thermal images

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3789662A (en) * 1971-10-26 1974-02-05 Instrumentation Labor Inc Calorimetry
US4021307A (en) * 1974-06-07 1977-05-03 Lkb-Produkter Ab Method and apparatus for measuring temperature changes generated by enzyme activity
WO1990000203A1 (en) * 1988-06-27 1990-01-11 Boehringer Mannheim Corporation Improved biosensor and the method of its use
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5255976A (en) * 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
US5813763A (en) * 1996-10-11 1998-09-29 Microcal Incorporated Ultrasensitive differential microcalorimeter
WO1999034206A1 (en) * 1997-12-23 1999-07-08 Studiengesellschaft Kohle Mbh Method for combinatorial material development using differential thermal images

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
G. LOWE: "combinatorial chemistry", CHEMICAL SOCIETY REVIEWS, 1995, pages 309 - 317, XP000974445 *
P. R. CONNELLY: "acquisition and use of calorimetric data for prediction of the thermodynamics of ligand-binding and folding reactions of proteins", CURRENT OPINION IN BIOTECHNOLOGY, vol. 5, 1994, pages 381 - 388, XP000974959 *

Also Published As

Publication number Publication date
EP1194767A2 (en) 2002-04-10
WO2001006250A2 (en) 2001-01-25
AU6103800A (en) 2001-02-05
JP2003504641A (en) 2003-02-04
CA2380283A1 (en) 2001-01-25

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