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WO2001005821A3 - Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis - Google Patents

Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis Download PDF

Info

Publication number
WO2001005821A3
WO2001005821A3 PCT/EP2000/006558 EP0006558W WO0105821A3 WO 2001005821 A3 WO2001005821 A3 WO 2001005821A3 EP 0006558 W EP0006558 W EP 0006558W WO 0105821 A3 WO0105821 A3 WO 0105821A3
Authority
WO
WIPO (PCT)
Prior art keywords
viral
metastasis
angiogenesis
tumorigenesis
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/006558
Other languages
French (fr)
Other versions
WO2001005821A2 (en
Inventor
Maria Teresa Bejarano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU58270/00A priority Critical patent/AU5827000A/en
Publication of WO2001005821A2 publication Critical patent/WO2001005821A2/en
Publication of WO2001005821A3 publication Critical patent/WO2001005821A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Various methods of use of viral IL-10s are provided. In particular, the method makes use of fact that viral IL-10 is capable of inhibiting angiogenesis, tumorigenicity, and metastasis.
PCT/EP2000/006558 1999-07-16 2000-07-11 Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis Ceased WO2001005821A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58270/00A AU5827000A (en) 1999-07-16 2000-07-11 Viral il-10 uses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35483399A 1999-07-16 1999-07-16
US09/354,833 1999-07-16
US16362799P 1999-11-04 1999-11-04
US60/163,627 1999-11-04

Publications (2)

Publication Number Publication Date
WO2001005821A2 WO2001005821A2 (en) 2001-01-25
WO2001005821A3 true WO2001005821A3 (en) 2001-07-19

Family

ID=26859813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006558 Ceased WO2001005821A2 (en) 1999-07-16 2000-07-11 Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis

Country Status (2)

Country Link
AU (1) AU5827000A (en)
WO (1) WO2001005821A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1324779B1 (en) 2000-09-29 2011-07-20 Schering Corporation Pegylated interleukin-10
JPWO2002066069A1 (en) * 2001-02-20 2004-09-24 関西ティー・エル・オー株式会社 Inflammatory / neoplastic disease treatment
EP2468293B1 (en) * 2006-09-28 2014-10-22 Merck Sharp & Dohme Corp. Use of pegylated il-10 to prevent metastasis of a cancer or tumor to the lung
CN103601800B (en) 2008-12-17 2015-10-21 默沙东公司 The production of single and double PEG IL10 and purposes
CN105209054A (en) 2013-04-18 2015-12-30 阿尔莫生物科技股份有限公司 Methods of treating diseases and conditions using interleukin-10
EP3434277A1 (en) 2013-06-17 2019-01-30 Armo Biosciences, Inc. Method for assessing protein identity and stability
JP6509867B2 (en) 2013-08-30 2019-05-08 アルモ・バイオサイエンシーズ・インコーポレイテッド Methods of using interleukin-10 to treat diseases and disorders
EP3068425B1 (en) 2013-11-11 2021-01-27 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
US10293043B2 (en) 2014-06-02 2019-05-21 Armo Biosciences, Inc. Methods of lowering serum cholesterol
JP2017536098A (en) 2014-10-14 2017-12-07 アルモ・バイオサイエンシーズ・インコーポレイテッド Interleukin-15 composition and use thereof
EP3209320B1 (en) 2014-10-22 2023-03-08 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
WO2016126615A1 (en) 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
HK1246201A1 (en) 2015-05-28 2018-09-07 Armo Biosciences, Inc. Pegylated interleukin-10 for use in treating cancer
US10398761B2 (en) 2015-08-25 2019-09-03 Armo Biosciences, Inc. Methods of using combinations of PEG-IL-10 and IL-15 for treating cancers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012725A1 (en) * 1991-01-16 1992-08-06 Schering Corporation Treatment of neoplastic disease with interleukin-10
US5770190A (en) * 1995-07-14 1998-06-23 Schering Corporation Method of treatment of acute leukemia with inteleukin-10

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012725A1 (en) * 1991-01-16 1992-08-06 Schering Corporation Treatment of neoplastic disease with interleukin-10
US5770190A (en) * 1995-07-14 1998-06-23 Schering Corporation Method of treatment of acute leukemia with inteleukin-10

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BENJAMIN DAVID: "Interleukin-10 (IL-10)", CANCER TREATMENT RESEARCH, vol. 80, 1995, pages 305 - 319, XP000979179 *
BERMAN ROBERT M ET AL: "Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice.", JOURNAL OF IMMUNOLOGY, vol. 157, no. 1, 1996, pages 231 - 238, XP002158947, ISSN: 0022-1767 *
CERVENAK LASZLO ET AL: "Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10.", BLOOD, vol. 96, no. 7, 1 October 2000 (2000-10-01), pages 2568 - 2573, XP002159072, ISSN: 0006-4971 *
DE WAAL MALEFYT R ET AL: "THE BIOLOGY OF HUMAN AND VIRAL IL-10", CYTOKINE, vol. 3, no. 5, 1991, pages 500, XP002158949, ISSN: 1043-4666 *
HUANG SUYUN ET AL: "Interleukin 10 Suppresses Tumor Growth and Metastasis of Human Melanoma Cells : Potential Inhibition of Angiogenesis", CLINICAL CANCER RESEARCH, vol. 2, no. 12, December 1996 (1996-12-01), pages 1969 - 1979, XP000979204 *
KUNDU NAMITA ET AL: "Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer.", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 88, no. 8, 1996, pages 536 - 541, XP000979212, ISSN: 0027-8874 *
RICHTER GUENTHER ET AL: "Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.", CANCER RESEARCH, vol. 53, no. 18, 1993, pages 4134 - 4137, XP002158948, ISSN: 0008-5472 *
STEARNS M E ET AL: "IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice: IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression.", INVASION & METASTASIS, vol. 17, no. 2, March 1997 (1997-03-01), pages 62 - 74, XP000979206, ISSN: 0251-1789 *
STEARNS MARK ET AL: "Interleukin 10 (IL-10) Inhibition of Primary Human Prostate Cell-induced Angiogenesis : IL-10 Stimulation of Tissue Inhibitor of Metalloproteinase-1 and Inhibition of Matrix Metalloproteinase (MMP)-2/MMP-9 Secretion", CLINICAL CANCER RESEARCH, vol. 5, January 1999 (1999-01-01), pages 189 - 196, XP000979198 *

Also Published As

Publication number Publication date
WO2001005821A2 (en) 2001-01-25
AU5827000A (en) 2001-02-05

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