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WO2001004145A3 - Glutx polypeptide family and nucleic acids encoding same - Google Patents

Glutx polypeptide family and nucleic acids encoding same Download PDF

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Publication number
WO2001004145A3
WO2001004145A3 PCT/IB2000/001042 IB0001042W WO0104145A3 WO 2001004145 A3 WO2001004145 A3 WO 2001004145A3 IB 0001042 W IB0001042 W IB 0001042W WO 0104145 A3 WO0104145 A3 WO 0104145A3
Authority
WO
WIPO (PCT)
Prior art keywords
glutx
family
nucleic acids
acids encoding
glutx3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2000/001042
Other languages
French (fr)
Other versions
WO2001004145A2 (en
Inventor
Bernard Thorens
Mark Ibberson
Marc Uldry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Lausanne
Original Assignee
Universite de Lausanne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Lausanne filed Critical Universite de Lausanne
Priority to AU58403/00A priority Critical patent/AU5840300A/en
Publication of WO2001004145A2 publication Critical patent/WO2001004145A2/en
Publication of WO2001004145A3 publication Critical patent/WO2001004145A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides GLUTX1, GLUTX2 and GLUTX3, a family of novel isolated polypeptides, as well as a polynucleotides encoding GLUTX1, GLUTX2 and GLUTX3, and antibodies that immunospecifically bind to GLUTX1, GLUTX2 and GLUTX3, or any derivative, variant, mutant, or fragment of any one of the GLUTX family of polypeptides, polynucleotides or antibodies. The invention additionally provides methods in which the GLUTX family of polypeptides, polynucleotides and antibodies are used in detection and treatment of a broad range of pathological states, such as aberrant hexose transport, as well as to other uses.
PCT/IB2000/001042 1999-07-14 2000-07-14 Glutx polypeptide family and nucleic acids encoding same Ceased WO2001004145A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58403/00A AU5840300A (en) 1999-07-14 2000-07-14 Glutx polypeptide family and nucleic acids encoding same

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US14390799P 1999-07-14 1999-07-14
US60/143,907 1999-07-14
US15114099P 1999-08-27 1999-08-27
US60/151,140 1999-08-27
US18428500P 2000-02-23 2000-02-23
US60/184,285 2000-02-23
US61613200A 2000-07-13 2000-07-13
US09/616,132 2000-07-13

Publications (2)

Publication Number Publication Date
WO2001004145A2 WO2001004145A2 (en) 2001-01-18
WO2001004145A3 true WO2001004145A3 (en) 2001-10-18

Family

ID=27495594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001042 Ceased WO2001004145A2 (en) 1999-07-14 2000-07-14 Glutx polypeptide family and nucleic acids encoding same

Country Status (2)

Country Link
AU (1) AU5840300A (en)
WO (1) WO2001004145A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7001735B2 (en) 2000-03-01 2006-02-21 Albert Einstein College Of Medicine Of Yeshiva University Glucose transporter/sensor protein and uses thereof
ATE483976T1 (en) * 2001-06-05 2010-10-15 Exelixis Inc GFATS AS P53 PATHWAY MODIFIERS AND METHODS OF USE
DE10305212A1 (en) * 2003-02-07 2004-08-19 Florian Prof. Dr.med. Lang Use of the sgk gene family for the diagnosis and therapy of cataracts and glaucoma
WO2006066408A1 (en) 2004-12-21 2006-06-29 Viventia Biotech Inc. Cancer specific antibody and cell surface proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942398A (en) * 1998-02-26 1999-08-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glutx and uses thereof
WO1999059559A1 (en) * 1998-05-15 1999-11-25 Joslin Diabetes Center Independent regulation of basal and insulin-stimulated glucose transport

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942398A (en) * 1998-02-26 1999-08-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glutx and uses thereof
WO1999059559A1 (en) * 1998-05-15 1999-11-25 Joslin Diabetes Center Independent regulation of basal and insulin-stimulated glucose transport

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
CARAYANNOPOULOS MARY O ET AL: "GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 13, 30 June 2000 (2000-06-30), June 30, 2000, pages 7313 - 7318, XP002157941, ISSN: 0027-8424 *
DOEGE HOLGER ET AL: "GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 21, 26 May 2000 (2000-05-26), pages 16275 - 16280, XP002157940, ISSN: 0021-9258 *
EMBL nucleotide and protein sequences. 01-08-91. AC = P22732. GLUCOSE TRANSPORTER TYPE 5, SMALL INTESTINE (FRUCTOSE TRANSPORTER); SLC2A5 OR GLUT5. Homo sapiens (Human). Kayano et al., 1990 *
EMBL nucleotide and protein sequences. 02-07-95. AC = H18721. Soares infant brain 1NIB Homo sapiens cDNA clone IMAGE:51047 5' similar to SP:GTR4_MOUSE P14142 GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE ;, mRNA sequence. EST *
EMBL Nucleotide and Protein sequences. Heidelberg,Germany 25-04-2000 AC= AB033418. Rattus norvegicus glut8 mRNA for glucose transporter 8, complete cds. "Molecular cloning of a new putative glucose transporter" Ishibashi K. et al., unpublished. *
EMBL nucleotide and protein. 01-10-94 AC = Q07647. GLUCOSE TRANSPORTER TYPE 3, BRAIN.SLC2A3 OR GLUT3 OR GLUT-3. Rattus norvegicus (Rat). Krishnan et al., 1995 *
EMBL, nucleotide and protein sequence. 02-07-95 AC = H09414. Soares infant brain 1NIB Homo sapiens cDNA clone IMAGE:46121 5' similar to SP:GTR5_HUMAN P22732 GLUCOSE TRANSPORTER TYPE 5, SMALL ;, mRNA sequence. EST. *
EMBL, nucleotide and protein sequences. 01-01-90 AC = P14142. GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE (GT2). SLC2A4 OR GLUT4 OR GLUT-4. Mus musculus (Mouse). Kaestner et al., 1989 *
EMBL, nucleotide and protein sequences. 14-08-96 AC = AA025081. Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:365292 5' similar to SW:GTR3_RAT Q07647 GLUCOSE TRANSPORTER TYPE 3, BRAIN. [1] ;, mRNA sequence. EST. *
EMBL, nucleotide and protein sequences. 21-04-95 AC = R11726. Soares infant brain 1NIB Homo sapiens cDNA clone IMAGE:25511 5' similar to SP:GTR4_MOUSE P14142 GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE ;, mRNA sequence. EST *
IBBERSON MARK ET AL: "GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 7, 18 February 2000 (2000-02-18), pages 4607 - 4612, XP002157939, ISSN: 0021-9258 *
KAESTNER K H ET AL: "SEQUENCE TISSUE DISTRIBUTION AND DIFFERENTIAL EXPRESSION OF MESSENGER RNA FOR A PUTATIVE INSULIN-RESPONSIVE GLUCOSE TRANSPORTER IN MOUSE 3T3-L1 ADIPOCYTES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 86, no. 9, 1989, 1989, pages 3150 - 3154, XP000978911, ISSN: 0027-8424 *
KAYANO T ET AL: "HUMAN FACILITATIVE GLUCOSE TRANSPORTERS ISOLATION FUNCTIONAL CHARACTERIZATION AND GENE LOCALIZATION OF COMPLEMENTARY DNA ENCODING AN ISOFORM GLUT5 EXPRESSED IN SMALL INTESTINE KIDNEY MUSCLE AND ADIPOSE TISSUE AND AN UNUSUAL GLUCOSE TRANSPORTER PSEUDOGENE-LIKE SEQUENCE GLUT6", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 22, 1990, pages 13276 - 13282, XP000978912, ISSN: 0021-9258 *
KRISHNAN S N ET AL: "CLONING OF GLUCOSE TRANSPORTER-3 (GLUT3) CDNA FROM RAT BRAIN", LIFE SCIENCES,GB,PERGAMON PRESS, OXFORD, vol. 56, no. 14, 24 February 1995 (1995-02-24), pages 1193 - 1199, XP002920075, ISSN: 0024-3205 *
MUECKLER M ET AL: "A MUTATION IN THE GLUT2 GLUCOSE TRANSPORTER GENE OF A DIABETIC PATIENT ABOLISHES TRANSPORT ACTIVITY", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 269, no. 27, 8 July 1994 (1994-07-08), pages 17765 - 17767, XP002032036, ISSN: 0021-9258 *
SHIMADA F: "IDENTIFICATION OF TWO NOVEL AMINO ACID POLYMORPHISMS IN BETA-CELL/ LIVER (GLUT2) GLUCOSE TRANSPORTER IN JAPANESE SUBJECTS", DIABETOLOGIA,DE,BERLIN, vol. 38, no. 2, 1995, pages 211 - 215, XP000674360, ISSN: 0012-186X *
T KITAGAWA ET AL: "A tumor-associated glycosylation change in the glucose transporter GLUT1 controlled by tumor suppressor function in human cell hybrids", JOURNAL OF CELL SCIENCE,GB,ESSEX, vol. pT 12, no. 108, 1 December 1995 (1995-12-01), pages 3735 - 3743, XP002076012 *

Also Published As

Publication number Publication date
AU5840300A (en) 2001-01-30
WO2001004145A2 (en) 2001-01-18

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