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WO2001002048A1 - Dispositif de manipulation de matiere radioactive - Google Patents

Dispositif de manipulation de matiere radioactive Download PDF

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Publication number
WO2001002048A1
WO2001002048A1 PCT/JP2000/004369 JP0004369W WO0102048A1 WO 2001002048 A1 WO2001002048 A1 WO 2001002048A1 JP 0004369 W JP0004369 W JP 0004369W WO 0102048 A1 WO0102048 A1 WO 0102048A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
outer cylinder
hollow needle
stopper
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2000/004369
Other languages
English (en)
Japanese (ja)
Inventor
Akiyo Shigematsu
Akiko Hatori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Whole Body Metabolism
Original Assignee
Institute of Whole Body Metabolism
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Whole Body Metabolism filed Critical Institute of Whole Body Metabolism
Publication of WO2001002048A1 publication Critical patent/WO2001002048A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F5/00—Transportable or portable shielded containers
    • G21F5/015—Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body

Definitions

  • the present invention relates to a device for preparing a medical solution of a radioactive substance to be used for missile therapy for patients with metastatic malignant tumor immediately before medical treatment.
  • An object of the present invention is to provide a handling device that can be operated easily and reliably without any radiation leakage to the outside when handling dangerous substances including radioactive substances.
  • Another object of the present invention is to safely, easily and surely prepare a drug solution containing radiation used for missile therapy of a malignant tumor without substantially leaking the radiation to the outside. It is to provide a device for administration to a patient. Disclosure of the invention
  • the radioactive substance handling device of the present invention is configured such that an opening is sealed with an outer cylinder and a first stopper through which a hollow needle can easily penetrate, and the opening is downwardly slidable into the outer cylinder.
  • a first container inserted, a needle member provided with a hollow needle with both ends sharpened to move axially inside the outer cylinder, and an opening sealed with a second plug through which the hollow needle can easily penetrate upward.
  • the inside of the outer cylinder which is inserted into and fixed to the lower end of the outer cylinder, has a second container whose pressure is lower than that of the first container.
  • the first stopper penetrates the upper end of the hollow needle and the second stopper penetrates the lower end of the hollow needle, so that the inside of the first container and the second container communicate with each other, and the contents in the first container. Can be safely and reliably moved into the second container without substantial radiation leakage to the outside It is characterized by having been done.
  • substantially means that there is no problem in terms of leakage from the viewpoint of radiation handling standards.
  • the material of the first container and the second container must be impermeable to the contained fluid and must be chemically inert to the internal fluid. Both containers are preferably transparent or translucent.
  • the material of the outer cylinder is preferably transparent or translucent.
  • the fluid to be handled is a radioactive substance that emits a relatively high-energy solid ray
  • the fluid is a radioactive substance that emits gamma rays or X-rays
  • the first and second stoppers are made of a soft material that can be penetrated by a hollow needle, for example, natural or synthetic rubber. None of the stoppers shall be permeable to the contained fluid unless penetrated.
  • the needle member having the hollow needle penetrating through the columnar member be slidable in the axial direction of the outer cylinder along the inner surface of the outer cylinder.
  • the hollow needle can always move the outer cylinder.
  • the material of the hollow needle is preferably chemically inert to at least the passing fluid.
  • the substance handling apparatus of the present invention can be used for both liquid and gas, but is particularly suitable for handling liquid. Initially, the fluid containing radioactive material does not come into contact with the inside of the first container in which the fluid is stored, the inner surface of the hollow needle, and the second container in which the fluid is moved. No local contamination occurs. If radiation shielding material is used for the outer cylinder, radiation exposure of workers can be prevented. The downward movement of the first container may be performed directly by mechanical means, or may be performed indirectly from outside the outer cylinder.
  • a slidable magnetic member is inserted into the outer cylinder, a magnet movable along the outer cylinder is provided outside the outer cylinder, and the magnet is moved along the outer cylinder, so that the magnetic member becomes While pressing the first container and moving in the outer cylinder, before the upper end of the hollow needle penetrates the stopper of the first container so that the first container moves in the outer cylinder, the lower end of the hollow needle is
  • a restricting member for temporarily restricting the lower end of the hollow needle may be provided between the needle member and the second container so as not to penetrate the second stopper.
  • a member such as paper which can be broken if necessary, is inserted and fixed at a position where the lower end of the hollow needle in the outer cylinder is to be temporarily stopped. Further, the needle member may be stopped.
  • the outer cylinder is divided into a first container storage part and a second container storage part, and the upper part of the second container can be opened by rotating or moving the first container storage part or the second container storage part. can do.
  • the mutual movement or rotation of the divided outer cylinders can be performed by rotating or moving the second container housing by an electric mechanism or the like while fixing the first container housing or by fixing the second container housing to the second container housing.
  • One container storage section can be rotated or moved by an electric mechanism.
  • a hollow tube is inserted into the second container so as to reach near the inner bottom.
  • the inserted hollow tube plays a role of taking out the contents in the second container out of the container.
  • a hollow tube is connected to the end of the hollow tube, and the end of the tube is connected to a catheter.
  • a radiopharmaceutical solution is prepared.
  • the prepared drug solution is It is administered to the human body through a catheter via a hollow tube inserted in the second container.
  • a chemical supply pump and a filter are provided between the hollow tube and the catheter.
  • a column using an ion exchange resin and activated carbon as a filler and a Millipore filter are used.
  • yttrium 90 for example, in a chemical solution is used, simple yttrium and zirconium are removed with an ion exchange resin, unreacted protein antibodies are removed with activated carbon, and activated carbon and other fine particles are removed using a millipore filter. To remove.
  • FIG. 1 is a view showing an apparatus for handling radioactive substances and the like according to the present invention.
  • FIG. 2 shows a jig used for the apparatus shown in FIG.
  • FIG. 3 is a view showing another handling device for a radioactive substance or the like according to the present invention.
  • FIG. 4 is a view showing a state in which the first container storage section is rotationally moved to open the second container storage section.
  • FIG. 5 is a diagram showing a state in which the first container storage section and the second container storage section are mutually moved.
  • FIG. 6 is a diagram showing a state of an upper part of the second container storage part.
  • FIG. 7 is a diagram showing a state in which a drug solution is administered to a patient using the device of the present invention.
  • FIG. 1 shows an example of the apparatus of the present invention.
  • the main body of the device is the outer cylinder 1, the first container to be inserted upside down into the outer cylinder 1. It comprises a vessel 2, an isolation membrane 5a provided at an intermediate portion of the outer casing 1, a needle member 4 vertically penetrated by a hollow needle 3, and a second container 6 inserted into a lower end lb of the outer casing 1.
  • the first container 2 containing a liquid such as a radioactive substance is inserted into the outer cylinder 1 with the opening sealed with a rubber stopper 2a which can be easily penetrated by the hollow needle 3 facing downward, facing downward.
  • the first container 2 is placed at a position where the bottom 2b is located a little further behind the upper end la of the outer cylinder 1.
  • An iron core 7 is inserted between the bottom 2b of the first container 2 and the upper end la of the outer cylinder 1. Lead is enclosed as a weight inside the iron core 7.
  • the filter paper 11 is bonded to the opening at the upper end la of the outer cylinder 1, and the upper end of the iron core 7 is further bonded to the filter paper 11 (however, the iron core 7 is separated from the filter paper 11 later).
  • a permanent magnet 8 is provided near the upper end la of the outer cylinder 1 so that the magnetic pole sandwiches the outer cylinder 1, and is temporarily fixed at this position at first.
  • An electromagnet 9 and a braking member 10 that can be moved up and down as necessary are provided in an intermediate portion of the outer cylinder 1.
  • a pair of slits 5 are provided at opposing positions on the wall of the outer cylinder 1 at a position substantially lower than the distance from the electromagnet 9 to the length of the first container 2 plus the length of the hollow needle 3. .
  • an isolation membrane 5 a made of filter paper or the like having an appropriate thickness and easily penetrated by the hollow needle 3 is inserted from the outside of the outer cylinder 1.
  • a needle member 4 formed by vertically penetrating a hollow needle 3 having both sharpened ends so that the hollow needle 3 is parallel to the axial direction of the outer cylinder 1 in the outer cylinder 1 immediately above the separator 5a. It is placed upright.
  • the needle member 4 is movable in the axial direction of the outer cylinder 1 in an upright state, and initially, the lower end 3b of the needle is in contact with the separation membrane 5a and is stationary.
  • the stopper 6a of the second container 6 is inserted into the opening of the lower end lb of the outer cylinder 1, so that both are airtightly adhered.
  • a stopper 13 is provided inside the outer cylinder 1 so that the stopper 6a is located at a predetermined distance from the electromagnet 9 when the stopper 6a is inserted into the outer cylinder 1. You. This predetermined distance will be described later in the description of the operation.
  • the lower end lb of the outer cylinder 1 is also sealed with the filter paper 12 (indicated by the dotted line) to protect the inside of the cylinder, like the upper end la.
  • the second container 6 may be provided with a sleeve 14 to protect it during transportation, and when the second container 6 is inserted into the lower end lb of the outer cylinder 1, the upper part of the sleeve 14 also becomes Is inserted outside the lower end of the lb.
  • the bottom of the second container 6 is in close contact with the vibrating part of the shaker 15 that provides mechanical vibration.
  • the whole device is fixed by a support 16.
  • FIG. 3 shows another embodiment of the present invention.
  • the main body of the device is an outer cylinder 31 whose upper part is divided into a first container storage part 51 and a lower part is divided into a second container storage part 50, and the first part which is inverted and inserted into the first container storage part 51.
  • a hollow needle 33 is formed by a needle member 34 formed by vertically penetrating a columnar member.
  • the first container 32 containing the liquid of the radioactive substance is inverted and inserted into the first container storage part 51 with the opening sealed with a rubber stopper 32a that can be easily penetrated by a needle facing downward.
  • the first container 32 is initially placed at a position where the bottom 32b is slightly deeper than the upper end 3 la of the outer cylinder 31.
  • An iron core 37 is inserted between the bottom 32b of the first container 32 and the upper end 31a of the outer cylinder 31. Lead is enclosed as a weight inside the iron core 37.
  • a filter paper 41 is adhered to the opening of the upper end 31a of the outer cylinder 31, and an upper end of the iron core 37 is further adhered to the filter paper 41.
  • a permanent magnet 38 is provided so that the magnetic pole sandwiches the outer cylinder 31, and is initially temporarily fixed at this position.
  • An electromagnet 39 and a control that can be moved up and down as necessary A moving member 40 is provided.
  • an isolation membrane 35a such as filter paper that can be easily penetrated with a needle having an appropriate thickness is inserted.
  • a needle member 34 having a hollow needle 33 having both sharp ends penetrating the columnar member upward and downward is placed upright in the outer cylinder 31 immediately above the separator 35a.
  • the needle member 34 is movable in the axial direction of the outer cylinder 31 while being in an upright state. Initially, the lower end 33b of the hollow needle 33 is in contact with the separator 35a and is stationary.
  • the stopper 36a of the second container 36 is inserted into an opening of 3 lb at the lower end of the lower second container housing portion 50 of the outer cylinder 31, and both are airtightly adhered.
  • a stopper 43 is provided inside the outer cylinder 31 so that the stopper 36a is located at a predetermined distance from the electromagnet 39 when the stopper 36a is inserted into the second container storage part 50.
  • the lower end 31b of the second container storage section 50 is also sealed with a filter paper 42 (indicated by a dotted line) to protect the inside of the cylinder, similarly to the upper end 3la.
  • the second container 36 may be provided with a sleeve 44 for protecting it during transportation, and when the second container 36 is inserted into the lower end 31b of the second container storage 50, the sleeve 44 The upper part is also inserted outside the lower end 31b of the second container storage part 50.
  • the bottom of the second container 36 is in close contact with the vibrating part of the shaker 45 to provide mechanical stirring.
  • a stirrer such as a magnetic stirrer can be used instead of the shaker.
  • the whole device is fixed by a column 46.
  • This embodiment is different from the embodiment of FIG. 1 described above in that the outer cylinder 31 is basically divided into a first container storage 51 and a second container storage 50. Different. Other portions have a structure substantially similar to that of the embodiment of FIG. 1 described above. By dividing the outer cylinder 31 into two parts, the outer cylinder 31 is divided into a part in which the first container 32 is stored and a part in which the second container 36 is stored. The operation of administering the radiopharmaceutical liquid prepared in the second container 36 to the human body is significantly improved.
  • the first container storage section 51 is held on a support column 46 with a rotary support 49, and the second container storage section 50 is supported on a support column 48 with a support column 48.
  • the first container storage part 51 is rotated around the column 46 by the rotation support 49.
  • the first container storage 51 is rotated, for example, 90 degrees, the upper part of the second container 36 inserted in the second container storage 50 is opened.
  • the storage portion 51 of the first container is rotated around the column 46, but the second container storage portion 50 may be rotated. Further, either the first container storage section 51 or the second container storage section 50 may be moved right and left. It is only necessary that the upper part of the second container storage part is opened from the inside of the cylinder.
  • the first container storage section 51 and the second container storage section 50 can be connected by a hinge 66 so that they can rotate with each other. In this case, rotation is performed by one shaft (shaft) provided on hinge 66.
  • the yttrium 90 contained in the first container 32 is transferred via the hollow needle 33 into the second container 36, where it reacts with the monoclonal antibody.
  • the drug solution thus prepared in the second container 36 is administered to a human body.
  • a hollow tube 61 is inserted into the second container 36 to the bottom of the container 36.
  • the tube 62 is connected to the hollow tube 61.
  • the tube 62 is connected to a Helister pump 65 via a column 63 filled with ion exchange resin and activated carbon and a Millipore filter 64, and finally to a human body. Is administered. This situation is shown in FIG. [Operation (Part 1)]
  • the isolation membrane 5a is inserted into the slit 5 of the outer cylinder 1, and the needle member 4, the braking member 10, the first container 2, and the iron core 7 are inserted into the outer cylinder 1 in this order.
  • the needle member 4 descends and stops until the lower end 3b of the hollow needle 3 contacts the separator 5a.
  • the first container 2 moves in the outer cylinder 1 with the lower end in contact with the braking member 10 and the upper end (bottom 2b) in contact with the iron core 7, and the upper end of the iron core 7 Stops when it matches the upper end la of the outer cylinder 1.
  • the filter paper 11 is adhered to both of them, and the upper end la of the outer cylinder 1 is sealed.
  • the lower end lb of the outer cylinder 1 is also sealed with the filter paper 12.
  • the filter paper 12 sealing the lower end lb of the outer cylinder 1 is removed, and the upper part of the stopper 6 a of the second container 6 is inserted into the opening of the lower end lb to the stopper 13.
  • An electric current is passed through the electromagnet 9 to activate the electromagnet.
  • a jig 21 (FIG. 2) composed of a bar having a knob 22 and a collar 23, the filter paper 11 at the upper end la of the outer cylinder 1 is broken, and the iron core 7 is pushed down slightly.
  • the permanent magnet 8 is moved downward from the vicinity of the upper end la of the outer cylinder 1 along the outside of the outer cylinder 1, the iron core 7 in the outer cylinder 1 moves downward while pressing the first container 2.
  • the damping member 10 moves while being pushed by the lower end 2b, and does not hinder the movement of the first container 2.
  • the iron core 7 approaches the electromagnet 9, it is attracted to the electromagnet 9 and stops.
  • the lower end 3b of the hollow needle 3 penetrating the needle member 4 breaks through the separation membrane 5a, Further, the upper end 3a of the hollow needle 3 pierces and penetrates the rubber stopper 2a by piercing and penetrating the stopper 6a at the upper end of the second container 6.
  • the hollow needle 3 passes through the rubber 2a to the first container 2 containing the fluid and the stopper 6a to the second container 6 that is depressurized.
  • the fluid in the second container 6 is transferred by the pressure difference with the second container 6.
  • the position of the stopper 13 provided near the lower end lb of the outer cylinder 1 is such that when the iron core 7 is attracted to the electromagnet 9 and stops, the lower end 3b of the hollow needle 3 passes through the stopper 6a at the upper end of the second container 6. Position.
  • the fluid transferred to the second container 6 is stirred and homogenized by the vibration of the shaker 15.
  • the second container 6 that has received the fluid is detached from the stopper 6a and separated from the lower end lb of the outer cylinder 1.
  • the first container 32 enclosing yttrium chloride is inserted into the upper end of the radiation shielding outer cylinder 31 of the radiopharmaceutical handling device, and is fixed by the permanent magnet 38.
  • the outer cylinder 31 is composed of a triple pipe consisting of a vinyl chloride pipe (thickness 10 mm), a stainless steel pipe (thickness lmm), and a lead pipe (thickness 10 mm).
  • the radiation dose of yttrium 90 enclosed in the first container 32 was able to enter the worker at a remote distance of lm from the outer cylinder 31 and work for 7 hours and Z days was possible without any problem.
  • Second container 3 6 contains a monoclonal antibody protein activity against tumors of the blood system; equivalent to 10 to 20 mg. Due to its physicochemical properties, IDEC's Y2B8 or the like, in which thioprea is bound to the structural end of the CD20 mouse antibody and DTPA (diethylenetriaminepentaacetic acid) is further bound, is suitable as this antibody.
  • IDEC's Y2B8 or the like in which thioprea is bound to the structural end of the CD20 mouse antibody and DTPA (diethylenetriaminepentaacetic acid) is further bound, is suitable as this antibody.
  • DTPA diethylenetriaminepentaacetic acid
  • the radiation shielding outer cylinder 31 is divided into a first container storage part 51 and a second container storage part 50.
  • the upper part of the second container 36 is opened by the mutual rotation or movement of the first container storage part 51 and the second container storage part 50.
  • the first container storage unit 51 and the second container storage unit 50 are continuous.
  • An isolation membrane 35a synthetic fiber such as filter paper, millibore, etc.
  • the needle members of the hollow needles at both ends are placed near the center of the separator.
  • the upper and lower ends of the outer cylinder 3 are designed so as to maintain sterility by closely attaching a similar thin filter film.
  • the outer cylinder 31 is turned over and loaded and fixed in an outer box (an outer case of a violin). Then, the entire outer box is shipped to the place of use.
  • the leakage dose outside the box in this case was specified below 0.01 microsievert and was within the provisions for general type A transport.
  • Yttrium 90 anti-mouse CD20 antibody is considered appropriate for non-Hodgkin's disease patients who require cancer missile therapy.
  • 3 Radiation dose for internal treatment typically 0.4 mCi (l. 48 GBg ) / Kg body weight) is administered.
  • a set of instruments including a container loaded with therapeutic yttrium 90 is taken out of the outer box and fixed to the column 46. Work during this time The external exposure of workers by the industry is 0.05 microsievert Z. The time required for the work is less than 5 minutes. After the instrument is secured, the electrical connections required for remote operation are made (electrical connections are not shown).
  • An electric current is passed through the electromagnet 39 to activate the electromagnet.
  • the permanent magnet 38 is moved downward from the vicinity of the upper end 31a of the outer cylinder 31 along the outside of the outer cylinder 31, the iron core 37 in the outer cylinder 31 moves downward while pressing the first container 32.
  • the braking member 40 moves while being pushed by the lower end 32b.
  • the iron core 37 approaches the electromagnet 39, it is attracted to the electromagnetic stone 39 and stops.
  • the lower end 33b of the hollow needle 33 that has penetrated the needle member 34 breaks through the separator 35a, pierces the stopper 36a at the upper end of the second container 36, penetrates it, and at the same time, the upper end of the hollow needle 33 33a penetrates through rubber stopper 32a.
  • the hollow needle 33 passes through the rubber stopper 32a to the first container 32 filled with yttrium 90, and passes through the stopper 36a to the depressurized second container 36, respectively.
  • the yttrium chloride 90 initially in the first container 32 is transferred to the second container 36 by a pressure difference. After the yttrium chloride 90 alone has completely moved into the second container 36, the magnetic stirrer 45 is activated.
  • a yttrium 90 chemical is stirred together with a sleeve 44 filled with cooling water (the center of the bottom is shaped so that it can be in close contact with the bottom of the second container).
  • the chemical is initially suspended, but becomes transparent over time. After sufficient reaction (approximately 20-30 minutes), stop mixing.
  • the switch After the formation of the yttrium 90-Y2B8 chelate, the switch is energized to rotate the first container compartment 90 degrees. By this operation the second container 3 The upper part of 6 appears.
  • FIG. 6 shows a state where the upper part of the second container 36 is exposed.
  • the hollow needle 33b below the needle member penetrates a stopper 36a provided at the opening of the second container 36.
  • a radiological technician connects a hollow tube 61 to the tip of an extension tube 62 (tube) for injection filled with physiological saline through lead glass.
  • the hollow tube 61 is connected to yttrium 90-chelating antibody. It pierces the stopper of the second container 36 containing the product liquid and passes it to the bottom.
  • the radiation exposure to human hands during this time is less than 0.5 microsievert Z hours and the working time is less than 1 minute.
  • Injection tube 62 is passed through a column and a millibore filter to remove unreacted material, including zirconium 90, and is injected into the patient's brachial vein through a helicopter pump.
  • the internal packing material of the column is a cation adsorption resin maintained at pH 7.5 and activated carbon.
  • the radioactive substance brazing apparatus of the present invention contacts only the inside of each of the first containers 2 and 32, the hollow needles 3 and 33, and the second containers 6 and 36. It does not contaminate the outside of the container and the hollow needle for transfer.
  • the present invention is used for transferring a radioactive liquid or the like from a first container to a second container, and reacting a radioactive liquid or the like in the first container with another substance in the second container. It is also useful for the purpose. For example, it is also useful for mixing a solution containing a high concentration of a beta- or gamma-ray radioisotope with a highly radiation-sensitive protein reagent immediately before use for medical or other purposes.
  • the device of the present invention enables the preparation of a drug solution containing radiation, and is effectively applied for the purpose of reacting a radioactive liquid or the like in the first container with another substance in the second container. be able to. It is useful for research on the transfer, reaction, and preparation of radioactive materials, research and development of pharmaceuticals, and medical purposes.

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  • Physics & Mathematics (AREA)
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  • High Energy & Nuclear Physics (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif de manipulation de matière radioactive, qui permet d'effectuer divers types de manipulations (tels que le transvasement de la matière radioactive d'un récipient à l'autre), ainsi que le mélange, la réaction et le contrôle de la matière par de simples opérations, sans laisser échapper des substances dangereuses, telle qu'une matière radioactive, vers l'extérieur. Le dispositif de manipulation comprend un tube extérieur, un premier récipient muni d'une ouverture fermée par un premier bouchon à travers lequel une aiguille peut passer facilement pour s'insérer par glissement dans le tube extérieur avec l'ouverture tournée vers le bas. Le dispositif comprend également une aiguille creuse aux deux extrémités effilées, qui peut être déplacée parallèlement à l'axe du tube extérieur. Le dispositif comprend en outre un second récipient muni d'une ouverture fermée par un second bouchon à travers lequel l'aiguille creuse peut passer facilement pour s'insérer solidement dans l'extrémité inférieure du tube extérieur. La pression dans le second récipient est réduite par rapport à celle qui s'exerce dans le premier récipient. Le premier récipient est glissé à l'intérieur du tube extérieur pour permettre à l'extrémité supérieure de l'aiguille creuse de traverser de part en part le second bouchon pour faire communiquer le premier récipient avec le second récipient aux fins de transvaser la matière du premier récipient vers le second récipient sans laisser échapper cette matière vers l'extérieur.
PCT/JP2000/004369 1999-07-06 2000-06-30 Dispositif de manipulation de matiere radioactive Ceased WO2001002048A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11/226781 1999-07-06
JP22678199 1999-07-06

Publications (1)

Publication Number Publication Date
WO2001002048A1 true WO2001002048A1 (fr) 2001-01-11

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Application Number Title Priority Date Filing Date
PCT/JP2000/004369 Ceased WO2001002048A1 (fr) 1999-07-06 2000-06-30 Dispositif de manipulation de matiere radioactive

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Country Link
WO (1) WO2001002048A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1632268A1 (fr) * 2004-09-03 2006-03-08 Mallinckrodt Inc. Conteneur pour matières radioactives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5238069Y2 (fr) * 1972-10-17 1977-08-30
JPH04329956A (ja) * 1991-04-30 1992-11-18 Takeda Chem Ind Ltd 個別密封容器に収容した薬剤の無菌保持混合装置
WO1994025101A1 (fr) * 1993-04-26 1994-11-10 Science Incorporated Systeme d'apport medicamenteux ferme
WO1996026702A1 (fr) * 1995-03-02 1996-09-06 Novo Nordisk A/S Kit permettant de stocker et de melanger des agents dont un, au moins, est liquide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5238069Y2 (fr) * 1972-10-17 1977-08-30
JPH04329956A (ja) * 1991-04-30 1992-11-18 Takeda Chem Ind Ltd 個別密封容器に収容した薬剤の無菌保持混合装置
WO1994025101A1 (fr) * 1993-04-26 1994-11-10 Science Incorporated Systeme d'apport medicamenteux ferme
WO1996026702A1 (fr) * 1995-03-02 1996-09-06 Novo Nordisk A/S Kit permettant de stocker et de melanger des agents dont un, au moins, est liquide

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1632268A1 (fr) * 2004-09-03 2006-03-08 Mallinckrodt Inc. Conteneur pour matières radioactives
WO2006135412A1 (fr) * 2004-09-03 2006-12-21 Mallinckrodt Inc. Conteneur pour matériau radioactif
US7753835B2 (en) 2004-09-03 2010-07-13 Mallinckrodt Inc. Radiation-shielding container assemblies, radioactive material administration devices, and methods of using the same

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