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WO2001000234A3 - Procedes et compositions pour la mise au point de vaccins attenues - Google Patents

Procedes et compositions pour la mise au point de vaccins attenues Download PDF

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Publication number
WO2001000234A3
WO2001000234A3 PCT/US2000/016984 US0016984W WO0100234A3 WO 2001000234 A3 WO2001000234 A3 WO 2001000234A3 US 0016984 W US0016984 W US 0016984W WO 0100234 A3 WO0100234 A3 WO 0100234A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
organisms
attenuated vaccines
vaccines
engineering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/016984
Other languages
English (en)
Other versions
WO2001000234A2 (fr
Inventor
Juha Punnonen
Russell Howard
Willem P C Stemmer
Stephen Delcardayre
Doris Apt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxygen Inc
Original Assignee
Maxygen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/344,655 external-priority patent/US6121736A/en
Application filed by Maxygen Inc filed Critical Maxygen Inc
Priority to EP00944760A priority Critical patent/EP1196552A2/fr
Priority to AU58809/00A priority patent/AU5880900A/en
Priority to JP2001505941A priority patent/JP2003503039A/ja
Priority to CA002377084A priority patent/CA2377084A1/fr
Publication of WO2001000234A2 publication Critical patent/WO2001000234A2/fr
Publication of WO2001000234A3 publication Critical patent/WO2001000234A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/255—Marek's disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/265—Infectious rhinotracheitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2720/12011—Reoviridae
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/12011—Astroviridae
    • C12N2770/12034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
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    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/24011—Flaviviridae
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    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention porte sur des vaccins atténués et sur des procédés visant à obtenir ces vaccins. Les vaccins de cette invention comprennent des parasites bactériens et viraux de recombinaison et autres organismes qui sont mis au point de façon à être fortement atténués sans que le vaccin perde son efficacité. Ces procédés consistent à créer des bibliothèques d'acides nucléiques de recombinaison (à savoir, des génomes entiers ou partiels, ou en particulier des acides nucléiques) qui sont introduits dans les virus ou autres organismes composant le vaccin, puis à rechercher systématiquement et/ou sélectionner ces virus ou organismes qui ont été atténués.
PCT/US2000/016984 1999-06-25 2000-06-20 Procedes et compositions pour la mise au point de vaccins attenues Ceased WO2001000234A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00944760A EP1196552A2 (fr) 1999-06-25 2000-06-20 Procedes et compositions pour la mise au point de vaccins attenues
AU58809/00A AU5880900A (en) 1999-06-25 2000-06-20 Methods and compositions for engineering of attenuated vaccines
JP2001505941A JP2003503039A (ja) 1999-06-25 2000-06-20 弱毒化したワクチンの操作のための方法および組成物
CA002377084A CA2377084A1 (fr) 1999-06-25 2000-06-20 Procedes et compositions pour la mise au point de vaccins attenues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/344,655 US6121736A (en) 1998-07-10 1999-06-25 Control apparatus for motor, and motor unit having the control apparatus
US09/344,655 1999-06-25

Publications (2)

Publication Number Publication Date
WO2001000234A2 WO2001000234A2 (fr) 2001-01-04
WO2001000234A3 true WO2001000234A3 (fr) 2001-08-02

Family

ID=23351426

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016984 Ceased WO2001000234A2 (fr) 1999-06-25 2000-06-20 Procedes et compositions pour la mise au point de vaccins attenues

Country Status (5)

Country Link
EP (1) EP1196552A2 (fr)
JP (1) JP2003503039A (fr)
AU (1) AU5880900A (fr)
CA (1) CA2377084A1 (fr)
WO (1) WO2001000234A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153655B2 (en) 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
US7262012B2 (en) 2002-05-17 2007-08-28 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function using varied exonuclease digestion in two polynucleotide populations
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
US7563578B2 (en) 2000-12-12 2009-07-21 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
CN108641993A (zh) * 2018-05-17 2018-10-12 新疆农垦科学院 一种食品级表达牛病毒性腹泻病毒e2蛋白的重组乳酸菌口服疫苗株

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6764835B2 (en) 1995-12-07 2004-07-20 Diversa Corporation Saturation mutageneis in directed evolution
WO2007060725A1 (fr) * 2005-11-24 2007-05-31 The Research Foundation For Microbial Diseases Of Osaka University Vaccin polyvalent recombiné
NZ592249A (en) * 2008-09-26 2013-03-28 Ambrx Inc Non-natural amino acid replication-dependent microorganisms and vaccines
WO2011153351A2 (fr) * 2010-06-02 2011-12-08 Virginia Tech Intellectual Properties, Inc. Vaccins vivants atténués inédits et vaccins sous-unitaires créés par recombinaison aléatoire de l'adn (« dna shuffling ») contre le virus du syndrome reproducteur et respiratoire porcin (vsrrp)
CA2892221A1 (fr) * 2012-12-19 2014-06-26 Intervet International B.V. Isolats de parvovirus canin de type 2c et procedes d'utilisation
JP2014236748A (ja) * 2014-08-26 2014-12-18 一般財団法人阪大微生物病研究会 組換え多価ワクチン
CN109312351B9 (zh) * 2016-04-26 2020-10-23 伦敦卫生及热带医学学院 呼肠孤病毒科疫苗
US10174295B1 (en) * 2017-08-01 2019-01-08 The Charles Stark Draper Laboratory, Inc. Composition of matter: engineering of Escherichia coli phage K1E
US11224649B2 (en) * 2018-10-31 2022-01-18 Boehringer Ingelheim Vetmedica Gmbh 4/91 IBV vaccine with heterologous spike protein
CN110184242B (zh) * 2019-06-11 2021-08-20 武汉生物制品研究所有限责任公司 柯萨奇病毒a组6型(cva6)的小鼠强毒力攻毒株及其应用
GB202009701D0 (en) * 2020-06-25 2020-08-12 Theolytics Ltd Generation of diverse viral libraries
CN113061581A (zh) * 2021-03-22 2021-07-02 华中农业大学 一种山羊源牛疱疹病毒1型毒株及其应用
CN116036253B (zh) * 2022-11-24 2023-12-26 畜科生物工程有限公司 一种猪繁殖与呼吸综合征活疫苗及其制备方法
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020078A1 (fr) * 1995-11-30 1997-06-05 Maxygen, Inc. Procede d'elaboration de polynucleotides presentant des caracteristiques desirees par selection iterative et recombinaison
WO1999023107A1 (fr) * 1997-10-31 1999-05-14 Maxygen, Incorporated Modification du tropisme viral et de la diversite d'especes hote par recombinaison du genome viral

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020078A1 (fr) * 1995-11-30 1997-06-05 Maxygen, Inc. Procede d'elaboration de polynucleotides presentant des caracteristiques desirees par selection iterative et recombinaison
WO1999023107A1 (fr) * 1997-10-31 1999-05-14 Maxygen, Incorporated Modification du tropisme viral et de la diversite d'especes hote par recombinaison du genome viral

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A. CRAMERI ET AL.: "DNA shuffling of a family of genes from diverse species accelerates directed evolution", NATURE, vol. 391, 1998, pages 288 - 291, XP002159048 *
P. PATTEN ET AL.: "Applicationsof DNA shuffling to phamaceuticals and vaccines", CURRNT OPINION IN BIOTECHNOLOGY, vol. 8, 1997, pages 724 - 733, XP002916609 *
W. STEMMER AT AL.: "DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution", PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 10747 - 10751, XP002087463 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
US7153655B2 (en) 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
US7563578B2 (en) 2000-12-12 2009-07-21 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
US7262012B2 (en) 2002-05-17 2007-08-28 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function using varied exonuclease digestion in two polynucleotide populations
CN108641993A (zh) * 2018-05-17 2018-10-12 新疆农垦科学院 一种食品级表达牛病毒性腹泻病毒e2蛋白的重组乳酸菌口服疫苗株

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