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WO2001096548A3 - Human n-acetyltransferase family member and uses thereof - Google Patents

Human n-acetyltransferase family member and uses thereof Download PDF

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Publication number
WO2001096548A3
WO2001096548A3 PCT/US2001/041043 US0141043W WO0196548A3 WO 2001096548 A3 WO2001096548 A3 WO 2001096548A3 US 0141043 W US0141043 W US 0141043W WO 0196548 A3 WO0196548 A3 WO 0196548A3
Authority
WO
WIPO (PCT)
Prior art keywords
conat
nucleic acid
acid molecules
expression vectors
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/041043
Other languages
French (fr)
Other versions
WO2001096548A2 (en
Inventor
Rosana Kapeller-Libermann
Mark Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU2002213598A priority Critical patent/AU2002213598A1/en
Priority to EP01984016A priority patent/EP1313842A2/en
Publication of WO2001096548A2 publication Critical patent/WO2001096548A2/en
Anticipated expiration legal-status Critical
Publication of WO2001096548A3 publication Critical patent/WO2001096548A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides isolated nucleic acid molecules, designated CONAT-1 nucleic acid molecules, which encode novel acetyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CONAT-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CONAT-1 gene has been introduced or disrupted. The invention still further provides isolated CONAT-1 proteins, fusion proteins, antigenic peptides and anti-CONAT-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/041043 2000-06-16 2001-06-18 Human n-acetyltransferase family member and uses thereof Ceased WO2001096548A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002213598A AU2002213598A1 (en) 2000-06-16 2001-06-18 Human n-acetyltransferase family member and uses thereof
EP01984016A EP1313842A2 (en) 2000-06-16 2001-06-18 Human n-acetyltransferase family member and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21243900P 2000-06-16 2000-06-16
US60/212,439 2000-06-16
US64492900A 2000-08-23 2000-08-23
US09/644,929 2000-08-23

Publications (2)

Publication Number Publication Date
WO2001096548A2 WO2001096548A2 (en) 2001-12-20
WO2001096548A3 true WO2001096548A3 (en) 2003-02-06

Family

ID=26907145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/041043 Ceased WO2001096548A2 (en) 2000-06-16 2001-06-18 Human n-acetyltransferase family member and uses thereof

Country Status (3)

Country Link
EP (1) EP1313842A2 (en)
AU (1) AU2002213598A1 (en)
WO (1) WO2001096548A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004612A2 (en) * 2000-07-07 2002-01-17 Incyte Genomics, Inc. Drug metabolizing enzymes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004612A2 (en) * 2000-07-07 2002-01-17 Incyte Genomics, Inc. Drug metabolizing enzymes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 4 December 1998 (1998-12-04), "Homo sapiens cDNA similar to N-acetyltransferase", XP002210479, retrieved from EBI Database accession no. AI298002 *
DATABASE EMBL [online] XP002210478, retrieved from EBI *
DATABASE INTERPRO [online] EMBL; "GCN5-related N-acetyltransferase", XP002210480, retrieved from EBI Database accession no. IPR000182 *
DYDA F ET AL: "GCN5-related N-acetyltransferases: a structural overview.", ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE. UNITED STATES 2000, vol. 29, 2000, pages 81 - 103, XP002210477, ISSN: 1056-8700 *
NEUWALD A F ET AL: "GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 22, no. 5, 1 May 1997 (1997-05-01), pages 154 - 155, XP004061752, ISSN: 0968-0004 *

Also Published As

Publication number Publication date
AU2002213598A1 (en) 2001-12-24
EP1313842A2 (en) 2003-05-28
WO2001096548A2 (en) 2001-12-20

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