[go: up one dir, main page]

WO2001094306A3 - (bis)sulfonamide derivatives - Google Patents

(bis)sulfonamide derivatives Download PDF

Info

Publication number
WO2001094306A3
WO2001094306A3 PCT/US2001/010829 US0110829W WO0194306A3 WO 2001094306 A3 WO2001094306 A3 WO 2001094306A3 US 0110829 W US0110829 W US 0110829W WO 0194306 A3 WO0194306 A3 WO 0194306A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
represent hydrogen
independently represent
derivatives
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/010829
Other languages
French (fr)
Other versions
WO2001094306A2 (en
Inventor
James Allen Knobelsdorf
Hamideh Zarrinmayeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to US10/275,335 priority Critical patent/US20040054009A1/en
Priority to AU2001262932A priority patent/AU2001262932A1/en
Priority to EP01937169A priority patent/EP1292571A2/en
Publication of WO2001094306A2 publication Critical patent/WO2001094306A2/en
Publication of WO2001094306A3 publication Critical patent/WO2001094306A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides bissulphonamide derivatives of formula (I), in which R1 represents C¿1-6?-alkyl, C2-6-alkenyl, or NR?7R8,R2 and R3¿ each independently represent hydrogen, C¿1-4?.alkyl, F, aryl, or C1-6.alkylaryl; R?4 and R5¿ each represent hydrogen; R6 represents C¿1-6?-alkyl; n is an integer from 7 to 14; and R?7 and R8¿ each independently represent hydrogen or C¿1-4?-alkyl; or a pharmaceutically acceptable salt thereof. Bissulphonamide derivatives of formula (I), in which R?1¿ represents C¿1-6?-alkyl, C2-6-alkenyl, or NR?7R8, R2, R2, R4, and R5¿ each represent hydrogen; R6 represents C¿1-6?-alkyl; n is an integer from 6 to 14; and R?7 and R8¿ each independently represent hydrogen or C¿1-4?-alkyl; or a pharmaceutically acceptable salt thereof; are useful for potentiating glutamate receptor function in a mammal and, therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
PCT/US2001/010829 2000-06-06 2001-05-23 (bis)sulfonamide derivatives Ceased WO2001094306A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/275,335 US20040054009A1 (en) 2001-05-23 2001-05-23 (BIS)sulfonamide derivatives
AU2001262932A AU2001262932A1 (en) 2000-06-06 2001-05-23 (bis)sulfonamide derivatives
EP01937169A EP1292571A2 (en) 2000-06-06 2001-05-23 (bis)sulfonamide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20967500P 2000-06-06 2000-06-06
US60/209,675 2000-06-06

Publications (2)

Publication Number Publication Date
WO2001094306A2 WO2001094306A2 (en) 2001-12-13
WO2001094306A3 true WO2001094306A3 (en) 2002-05-23

Family

ID=22779775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010829 Ceased WO2001094306A2 (en) 2000-06-06 2001-05-23 (bis)sulfonamide derivatives

Country Status (3)

Country Link
EP (1) EP1292571A2 (en)
AU (1) AU2001262932A1 (en)
WO (1) WO2001094306A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2915405A1 (en) 2013-06-13 2014-12-18 Veroscience Llc Compositions and methods for treating metabolic disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033496A1 (en) * 1997-02-04 1998-08-06 Eli Lilly And Company Sulphonamide derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033496A1 (en) * 1997-02-04 1998-08-06 Eli Lilly And Company Sulphonamide derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. VANDI, ET AL.: "Some amonolysis and deamonation reactions of dialkylsulphanyl chlorides and sulphamide with polyamines", JOURNAL OF ORGANIC CHEMISTRY, vol. 26, no. 9, 12 September 1961 (1961-09-12), American Chemical Society, Washington, DC, US, pages 3478 - 3480, XP002187582, ISSN: 0022-3263 *
G. WEISS, ET AL.: "Herstellung und Reaktionen von N-Monoalkylamidosulfonylchloriden", LIEBIGS ANNALEN DER CHEMIE, vol. 729, December 1969 (1969-12-01), Verlag Chemie, Weinheim, DE, pages 40 - 51, XP002187581, ISSN: 0170-2041 *
H.A. OFFE: "Über die Electrolyse von Aminosäure-Derivaten", ZEITSCHRIFT FUER NATURFORSCHUNG., vol. 2b, 1947, Dietrich'sche Verlagsbuchhandlung, Wiesbaden, DE, pages 182 - 184, XP001052935 *
M. COHEN: "New epoxide resins by reaction of epichlorohydrin with sulphonamides", INDUSTRIAL AND ENGINEERING CHEMISTRY., vol. 47, no. 10, October 1955 (1955-10-01), American Chemical Society, Washington, DC, US, pages 2095 - 2101, XP001042164 *

Also Published As

Publication number Publication date
AU2001262932A1 (en) 2001-12-17
EP1292571A2 (en) 2003-03-19
WO2001094306A2 (en) 2001-12-13

Similar Documents

Publication Publication Date Title
CY1117132T1 (en) THEAZOLI PRODUCTION
EP0860428A3 (en) Sulphonamide derivatives
ATE255564T1 (en) IMIDAZOLE DERIVATIVE
BG103964A (en) SUBSTITUTED PYRAZOLS AS p38 KINASE INHIBITORS
WO2002057252A3 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
EA199800348A1 (en) SUBSTITUTED TETRACYCLIC DERIVATIVES OF TETRAHYDROFURANE
DE60104697D1 (en) SULFONAMIDE DERIVATIVES
MY138826A (en) 2,7-substituted indoles
WO2000066546A3 (en) Monofluoroalkyl derivatives
CY1108837T1 (en) New aminopyridine derivatives as mGluR5 antagonists
WO2002014275A3 (en) Heterocyclic sulfonamide derivatives and their use for potentiating glutamate receptor function
WO2002014294A3 (en) Heterocyclic sulfonamide derivatives and their use for potentiating glutamate receptor function
WO2001094306A3 (en) (bis)sulfonamide derivatives
FI956151A0 (en) Benzene derivatives useful in ischemic diseases
ATE168686T1 (en) N,N'-DISUBSTITUTED AMIDE DERIVATIVES
AP2002002595A0 (en) Heterocyclic amide derivatives.
BG105247A (en) N-substituted azabicycloheptane derivatives, production and use thereof
WO1997017334A1 (en) Sydnone imine derivatives
AU7332996A (en) Therapeutics for thrombocytopenia
PT1214312E (en) INDOLES 5-AMINOALQUIL AND SUBSTITUTED 5-AMINOCARBONYL
WO2002040465A3 (en) Aryloxy piperidinyl indoles for treating depression

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10275335

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2001937169

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001937169

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2001937169

Country of ref document: EP