WO2001091747A1

WO2001091747A1 - Use of ace inhibitors for treatment of patients suffering from behavioral disorders

Info

Publication number: WO2001091747A1
Application number: PCT/US2001/017451
Authority: WO
Inventors: Robert C. Kevorkian
Original assignee: Individual
Current assignee: Individual
Priority date: 2000-06-01
Filing date: 2001-05-30
Publication date: 2001-12-06
Anticipated expiration: 2002-12-01
Also published as: CA2411261A1; AU2001265185A1

Abstract

A method for the treatment of a patient suffering from a behavioral disorder, comprising administering to the patient a therapeutic quantity of at least one ACE inhibitor. Disorders such as attention deficit disorder (ADD), obsessive-compulsive disorder (OCD), oppositional explosive defiant disorder (OEDD), anxiety and panic disorders (APD) and temper, rage and outburst behavior disorder (TROBD) are ameliorated by a regimen of ACE inhibitor.

Description

USE OF ACE INHIBITORS FOR TREATMENT OF PATIENTS SUFFERING FROM BEHAVIORAL DISORDERS

CROSS REFERENCE TO RELATED APPLICATION [0001] This application claims the benefit of U.S. provisional application number 60/208,637 filed June 1, 2000.

BACKGROUND OF THE INVENTION Field of the Invention [0002] Angiotensin converting enzyme inhibitors (ACE inhibitors) are known to be useful for treatment of a variety of cardiovascular ailments such as hypertension, heart failure, myo- cardial infarction, left ventricular dysfunction and diabetic nephropathy. ACE inhibitors are believed to inhibit the action of angiotensin-converting enzyme (ACE) in the body in its conversion of angiotensin I, a relatively inactive peptide, to angiotensin II, a powerful vasocon- strictor and stimulant of the adrenal cortex for the secretion of aldosterone, which is normally associated with fluid retention. Angiotensin I is the product of the action of renin, which is produced by the kidneys, on angiotensinogen (a globulin of plasma). The action of an ACE inhibitor, by reducing conversion of angiotensin I, relieves vasoconstriction and reduces aldosterone secretion. It also provides negative feedback on renin release, which is also believed to de- crease aldosterone secretion. ACE inhibitors also include angiotensin II antagonists.

[0003] Another possible basis for the effectiveness for ACE inhibitors is that ACE is identical to bradykininase (kininase II), which acts on bradykinin. Bradykinin stimulates prostaglan- din biosynthesis and it is believed that ACE inhibitors also inhibit bradykininase and thereby increase bradykinin levels. ACE inhibitors thus stimulate the biosynthesis of prostaglandin, which is a vasodilator and which may contribute to the pharmaceutical effects of ACE inhibitors.

[0004] The physiological effects associated with ACE inhibitors include increases in serum potassium and sodium and fluid loss, a reduction of peripheral arterial resistance in hypertensive patients and an increase in cardio output with little or no change in heart rate. There is also an increase in renal blood flow, reduction in blood pressure and an improvement in maximal exercise tolerance in patients with heart failure.

[0005] ACE inhibitors are characterized as peptides that fall into three groups: sulfhydryl- containing (e.g., captopril), dicarbocyl-containing (e.g., enalapril, lisinopril, benazepril, quina- pril, moexipril, trandolapril, and ramipril), and phosporous-containing (e.g., fosinopril). Other known ACE inhibitors are enalaprilat, irbesartan, losartan potassium and valsartan. The pharmaceutical dosages and administration of the various ACE inhibitors are known to those of ordinary skill in the art. Typically, the compositions are administered orally.

Related Art

[0006] In Drug Facts and Comparisons, January 2000, published by Facts and Comparisons, St. Louis, Missouri, certain "adverse reactions" of various ACE inhibitors are shown, including reactions pertaining to the central nervous system. Some of these include confusion, depression, malaise, nervousness and anxiety. When the incidence of these reactions were given, they almost all were reported in less than one percent of the persons treated. In addition, the following reactions were reported at incidences of less than one percent of the persons treated: dream abnormality (in connection with enalapril); memory disturbance, mood change and behavior change (in connection with fosinopril); irritability (in connection with lisinopril) and mood changes (in connection with moexipril).

SUMMARY OF THE INVENTION [0007] Generally, the present invention provides a method for the treatment of patients suffering from a behavioral disorder by administering to the patient a therapeutic quantity of at least one ACE inhibitor, such as a dicarbocyl-containing ACE inhibitor, e.g., lisinopril. [0008] Specifically, in accordance with the present invention there is provided a method for the treatment of a patient who suffers from a behavioral disorder, comprising administering to the patient at least one ACE inhibitor at a frequency and dosage sufficient to ameliorate at least some aspects of the disorder. [0009] The behavioral disorder may be one which is associated with the elevation of blood pressure. For example, the behavioral disorder may be one selected from the group consisting of attention deficit disorder (ADD), obsessive-compulsive disorder (OCD), oppositional explosive defiant disorder (OEDD), anxiety and panic disorders (APD) and temper, rage and outburst behavior disorder (TROBD). [0010] In accordance with one aspect of the present invention, the method comprises ad- ministering a dicarbocyl-containing ACE inhibitor, e.g., lisinopril.

[0011] In another aspect of the present invention, the at least one ACE inhibitor is administered to the patient by oral ingestion, e.g., by oral ingestion of at least one orally-ingestable, pre-measured unit dosage. [0012] A particular aspect of the present invention provides a method for the treatment of a patient who suffers from temper, rage and outburst behavior disorder (TROBD), the method comprising administering to the patient at least one ACE inhibitor as described above, e.g., administering a dicarbocyl-containing ACE inhibitor, e.g., lisinopril.

DETAILED DESCRIPTION OF THE INVENTION AND PREFERRED EMBODIMENTS THEREOF [0013] The present invention is based on the observation that beneficial behavioral modification effects are produced by ACE inhibitors, making ACE inhibitors useful for certain pa- tients for whom they might not otherwise be prescribed. These beneficial effects may be manifested as behavioral improvements in people, children and adults, who suffer from Attention Deficit Disorder (ADD), Obsessive Compulsive Disorder (OCD), Oppositional Explosive Defiant Disorder (OED), Anxiety and Panic Disorders (APD), and behaviors such as impulsive temper, rage and outburst behavior Disorder TROBD). Accordingly, the present invention pro- vides a new method for the treatment of persons with such disorders, comprising the administration of one or more ACE inhibitors in a therapeutic regimen that may parallel a regimen that would be used in those patients for the treatment of cardiovascular disease in which the ACE inhibitor would be indicated. Without wishing to be bound by any particular theory, it is believed that certain physiological conditions which are controllable through the use of ACE in- hibitors are related to certain behavioral problems. For example, the production of angiotensin II and its associated elevation of blood pressure appear to be correlated with outbursts of rage, anger and even violence. In two patients who volunteered to be studied, it was found that significantly elevated blood pressure accompanied temper outbursts. It is therefore believed that controlling these phenomena can help the patient control the undesired behavior. [0014] This invention is also expected to be useful for non-human patients whose cardiovascular systems are known to be affected by ACE inhibitors in a manner analogous to the reactions of humans to ACE inhibitors.

Example 1 [0015] A twelve-year old human male with an eight-year history of uncontrollable temper, rage and violent outburst behavior, i.e., a patient suffering from TROBD, was placed on a regimen of the dicarbocyl-containing ACE inhibitor lisinopril, 10 mg per day, oral administration. Prior to medication, the patient displayed two to four episodes of fit or rage and/or violent behavior per week, each lasting approximately twenty minutes per episode. When confined to his room, the patient would act out with banging and stomping. Episodes were accompanied by physiological changes including dilation of pupils, expressionless face and a rise in blood pressure. Prior treatments with methylphenidate (e.g., Ritalin), dextroamphetamine (e.g., Dexe- drine) and counseling were ineffective to provide adequate relief. [001 ] With lisinopril medication as noted above over a period of about four weeks, definite changes in behavior were evident. Episodes were reduced in duration and frequency to episodes of approximately five to ten minutes with a frequency of approximately one per week, without violent outburst. At home, he retreated from a situation triggering the event to his room, where he remained quiet. [0017] The patient exhibited improved behavior throughout a therapeutic regimen extending for a period of approximately two and one-half months. Under treatment, there was no noticeable dilation of pupils and blood pressure did not go over 128/64 during the three most marked temper-related episodes in that period. Each of the three episodes occurred at school. In one episode, the patient was working on a computer and refused to give up his work station when his allotted time had been used up. The teacher reported that the patient was verbally resistive and spilled his milk, but did not act out violently and, when so instructed, walked to the principal's office without being physically coerced. A second episode was triggered when the patient was asked to make up a class he had missed. He refused to go to the class but voluntarily moved himself to a "cooling room" to allow his temper to subside. He again, when so in- structed, walked to the school office without being physically coerced. In a third episode, the patient was asked to leave the classroom because he would not stop talking during a quiet time. In this case, there was a limited degree of acting out in that, while sitting in a chair, he kicked a desk which was knocked over. He then allowed himself to be escorted by police officers to the school office without being physically coerced. In the office, he kicked another desk and was taken by ambulance to a children's hospital for evaluation. The degree of violence in all of these episodes, including the third episode, was significantly reduced compared to the patient's behavior prior to treatment with the ACE inhibitor.

Example 2 [0018] The grandfather of the subject of Example 1 also had a long history of temper, rage and outburst behavior disorder (TROBD). After receiving an ACE inhibitor for treatment of his high blood pressure, his outbursts were markedly reduced.

Claims

THE CLAIMSWhat is claimed is:

1. A method for the treatment of a patient who suffers from a behavioral disorder, comprising administering to the patient at least one ACE inhibitor at a frequency and dosage sufficient to ameliorate at least some aspects of the disorder.

2. The method of claim 1 wherein the behavioral disorder is one associated with the elevation of blood pressure.

3. The method of claim 1 wherein the behavioral disorder is selected from the group consisting of attention deficit disorder (ADD), obsessive-compulsive disorder (OCD), oppositional explosive defiant disorder (OEDD), anxiety and panic disorders (APD) and temper, rage and outburst behavior disorder (TROB).

4. A method for the treatment of a patient who suffers from temper, rage and outburst behavior disorder (TROBD), the method comprising administering to the patient at least one ACE inhibitor at a dosage and frequency sufficient to ameliorate at least some aspects of the disorder.

5. The method of any one of claims 1 through 4, comprising administering a dicarbocyl-containing ACE inhibitor.

6. The method of any one of claims 1 through 4, comprising administering lisinopril.

7. The method of any one of claims 1-5 wherein the at least one ACE inhibitor is administered to the patient by oral ingestion of at least one orally-ingestable, pre-measured unit dosage. AMENDED CLAIMS

[received by the International Bureau on 27 September 2001 (27.09.01); original claim 7 amended; remaining claims unchanged (1 page)]

7. The method of any one of claims 1 through 4 wherein the at least one ACE inhibitor is administered to the patient by oral ingestion of at least one orally-ingestable, pre-measured unit dosage. STATEMENT UNDER ARTICLE 19 (1)

The amendment to claim 7 places it into conformance with the second and third sentences of Rule 6.4(a) by deleting reference to claim 5 which, like claim 7, is a multiple dependent claim.