[go: up one dir, main page]

WO2001089681A3 - Systeme de production chimique modulaire utilisant un microreacteur - Google Patents

Systeme de production chimique modulaire utilisant un microreacteur Download PDF

Info

Publication number
WO2001089681A3
WO2001089681A3 PCT/US2001/015738 US0115738W WO0189681A3 WO 2001089681 A3 WO2001089681 A3 WO 2001089681A3 US 0115738 W US0115738 W US 0115738W WO 0189681 A3 WO0189681 A3 WO 0189681A3
Authority
WO
WIPO (PCT)
Prior art keywords
product
modules
produce
microreactor
reactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/015738
Other languages
English (en)
Other versions
WO2001089681A2 (fr
Inventor
Thomas Schwalbe
Sebastian Oberbeck
Klaus Golbig
Michael Hohmann
Andreas Oberbeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellular Process Chemistry Inc
Original Assignee
Cellular Process Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/578,224 external-priority patent/US7056477B1/en
Application filed by Cellular Process Chemistry Inc filed Critical Cellular Process Chemistry Inc
Priority to EP01935559A priority Critical patent/EP1286761A2/fr
Priority to JP2001585914A priority patent/JP2004508919A/ja
Publication of WO2001089681A2 publication Critical patent/WO2001089681A2/fr
Anticipated expiration legal-status Critical
Publication of WO2001089681A3 publication Critical patent/WO2001089681A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00835—Comprising catalytically active material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00984—Residence time

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne un système de production chimique modulaire comprenant un microréacteur, destiné à la production d'un produit par mise en réaction d'au moins deux réactifs. La modularisation permet d'ajouter et d'enlever des composants, tels que des contrôleurs, des pompes, des soupapes, des microréacteurs, et des modules de traitement, selon les besoins, pour obtenir un produit désiré. Ce système comprend un module de commande et un module de réaction renfermant un volume de mélange et un volume de réaction. Plusieurs modules de pompage et de séjour peuvent également être inclus dans le système. Des raccords à engagement/dégagement rapide permettent un changement rapide des modules en cas de dysfonctionnement ou pour produire un produit ou une quantité différent. Une base de données comprend les paramètres optimaux pour une pluralité de réactions différentes permettant de produire différents produits chimiques. L'utilisateur sélectionne un produit et une quantité désirés, fournit les réactifs, les solvants et les agents caloporteurs, et le module de commande gère le système pour produire automatiquement le produit, jusqu'à obtention de la quantité désirée.
PCT/US2001/015738 2000-05-24 2001-05-15 Systeme de production chimique modulaire utilisant un microreacteur Ceased WO2001089681A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01935559A EP1286761A2 (fr) 2000-05-24 2001-05-15 Systeme de production chimique modulaire utilisant un microreacteur
JP2001585914A JP2004508919A (ja) 2000-05-24 2001-05-15 マイクロリアクタを組み入れたモジュラ式化学生産システム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/578,224 US7056477B1 (en) 2000-02-03 2000-05-24 Modular chemical production system incorporating a microreactor
US09/578,224 2000-05-24

Publications (2)

Publication Number Publication Date
WO2001089681A2 WO2001089681A2 (fr) 2001-11-29
WO2001089681A3 true WO2001089681A3 (fr) 2003-01-03

Family

ID=24311932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015738 Ceased WO2001089681A2 (fr) 2000-05-24 2001-05-15 Systeme de production chimique modulaire utilisant un microreacteur

Country Status (3)

Country Link
EP (1) EP1286761A2 (fr)
JP (1) JP2004508919A (fr)
WO (1) WO2001089681A2 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969506B2 (en) 1999-08-17 2005-11-29 Battelle Memorial Institute Methods of conducting simultaneous exothermic and endothermic reactions
DE10032059A1 (de) * 2000-07-05 2002-01-17 Mir Chem Gmbh Vorrichtung zum Ausführen einer katalytischen Rohrreaktion
AU2001284733B2 (en) 2000-08-08 2006-11-02 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxyalkylamines as H3 receptor ligands
US7071191B2 (en) 2000-08-08 2006-07-04 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines
DE10143189A1 (de) * 2001-09-04 2003-03-20 Clariant Gmbh Verfahren und Vorrichtung zur prozeßbegleitenden Reinigung von Mikro-und Minireaktoren
DE20201753U1 (de) 2002-02-05 2002-04-11 Ehrfeld Mikrotechnik GmbH, 55234 Wendelsheim Modulares Mikroreaktorsystem
DE10209897A1 (de) * 2002-03-08 2003-09-25 Merck Patent Gmbh Mikrokomponenten-Anschlusssystem
WO2004011134A1 (fr) * 2002-07-26 2004-02-05 Avantium International B.V. Systeme permettant de mettre en oeuvre une reaction chimique dans une pluralite de microreacteurs differents
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
US20070077179A1 (en) * 2003-05-09 2007-04-05 Dirk Schmalz Component used in microprocess control
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
DE102005013915A1 (de) * 2005-03-24 2006-09-28 Siemens Ag Verfahrenstechnische, insbesondere mikroverfahrenstechnische Anlage
CN101175563B (zh) 2005-09-08 2011-08-24 卡西欧计算机株式会社 反应器和电子装置
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
TW200738328A (en) 2006-03-31 2007-10-16 Lonza Ag Micro-reactor system assembly
WO2008061165A2 (fr) 2006-11-14 2008-05-22 Handylab, Inc. Cartouche microfluidique et son procédé de fabrication
WO2009002152A1 (fr) * 2007-06-26 2008-12-31 Micronit Microfluidics B.V. Dispositif et procédé permettant le couplage fluidique de conduits fluidiques à une puce microfluidique et leur découplage
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
WO2009092392A1 (fr) * 2008-01-22 2009-07-30 Siemens Aktiengesellschaft Module de processus pour réaliser une fonction industrielle prédéterminée
DE102008041950A1 (de) * 2008-09-10 2010-03-11 Evonik Degussa Gmbh System zur Bereitstellung einer universellen Infrastruktur für chemische Prozesse
EP2223741A1 (fr) * 2009-02-13 2010-09-01 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Système micro fluidique, incluant un amas de modules de procédé et modules d'échange thermique
JP4904374B2 (ja) * 2009-03-30 2012-03-28 東レエンジニアリング株式会社 マイクロリアクタ
TW201114481A (en) 2009-05-11 2011-05-01 Corning Inc Modular reactor and system
DE202010000262U1 (de) * 2009-05-12 2010-05-20 Lonza Ag Strömungsreaktor mit Mikrokanalsystem
DE202009017416U1 (de) 2009-05-12 2010-04-15 Lonza Ag Reaktor und Satz aus Reaktoren
USRE47124E1 (en) 2009-06-09 2018-11-13 Ge Healthcare Bio-Science Ab Automated fluid handling system
ES2617599T3 (es) 2011-04-15 2017-06-19 Becton, Dickinson And Company Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración
EP2773892B1 (fr) 2011-11-04 2020-10-07 Handylab, Inc. Dispositif de préparation d'échantillons de polynucléotides
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
US10780410B2 (en) 2014-08-15 2020-09-22 Massachusetts Institute Of Technology Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients
US11185839B2 (en) 2016-05-02 2021-11-30 Massachusetts Institute Of Technology Reconfigurable multi-step chemical synthesis system and related components and methods
WO2018200236A1 (fr) 2017-04-26 2018-11-01 Massachusetts Institute Of Technology Systèmes et procédés de synthèse chimique reconfigurables

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
WO1998038487A2 (fr) * 1997-02-28 1998-09-03 Cepheid Ensemble pour reaction chimique avec echange thermique et interrogee optiquement
WO2000062919A1 (fr) * 1999-04-16 2000-10-26 Norbert Schwesinger Microsysteme chimique modulaire
WO2001041916A1 (fr) * 1999-12-08 2001-06-14 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Systeme de microreaction modulaire
WO2001068257A1 (fr) * 2000-03-10 2001-09-20 Bioprocessors Corporation Microreacteur

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
WO1998038487A2 (fr) * 1997-02-28 1998-09-03 Cepheid Ensemble pour reaction chimique avec echange thermique et interrogee optiquement
WO2000062919A1 (fr) * 1999-04-16 2000-10-26 Norbert Schwesinger Microsysteme chimique modulaire
WO2001041916A1 (fr) * 1999-12-08 2001-06-14 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Systeme de microreaction modulaire
WO2001068257A1 (fr) * 2000-03-10 2001-09-20 Bioprocessors Corporation Microreacteur

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BERG VAN DEN A ET AL: "MODULAR CONCEPT FOR MINIATURE CHEMICAL SYSTEMS", DECHEMA MONOGRAPHIEN, VERLAG CHEMIE, WEINHEIM,, DE, vol. 132, 1995, pages 109 - 123, XP000925640, ISSN: 0070-315X *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9528142B2 (en) 2001-02-14 2016-12-27 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9480983B2 (en) 2011-09-30 2016-11-01 Becton, Dickinson And Company Unitized reagent strip
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder

Also Published As

Publication number Publication date
WO2001089681A2 (fr) 2001-11-29
EP1286761A2 (fr) 2003-03-05
JP2004508919A (ja) 2004-03-25

Similar Documents

Publication Publication Date Title
WO2001089681A3 (fr) Systeme de production chimique modulaire utilisant un microreacteur
Rogers et al. Continuous manufacturing–the Green Chemistry promise?
Chapman et al. Simple and versatile laboratory scale CSTR for multiphasic continuous-flow chemistry and long residence times
AU708281B2 (en) Integrated chemical synthesizers
Roberge et al. Microreactor technology: a revolution for the fine chemical and pharmaceutical industries?
Baraldi et al. Micro reactor and flow chemistry for industrial applications in drug discovery and development.
Schenk et al. Numbering-up of micro devices: a first liquid-flow splitting unit
ATE479645T1 (de) Durch metall-ligandkomplexe katalysierte herstellungsverfahren
Müller et al. Fluidic bus system for chemical process engineering in the laboratory and for small-scale production
EP1127611A3 (fr) Microsystèmes de traitement chimique avec d' analyse intégrée basée sur la séparation des produits de réaction
WO2005037709A3 (fr) Synthese regulee d'ecoulement d'aerosol chimique a base de particules nanometriques et autres produits namometriques
TW200624162A (en) Improved process for chemical reactions involving cyanohydrins
Knapkiewicz et al. Nitration under continuous flow conditions: convenient synthesis of 2-isopropoxy-5-nitrobenzaldehyde, an important building block in the preparation of nitro-substituted Hoveyda–Grubbs metathesis catalyst
Diab et al. Technoeconomic optimization of continuous crystallization for three active pharmaceutical ingredients: cyclosporine, paracetamol, and aliskiren
EP1720643B1 (fr) Melangeur a reseau et procede de melange associe
US8935847B2 (en) Modular reactive distillation emulation elements integrated with instrumentation, control, and simulation algorithms
Pedersen et al. Full-scale continuous mini-reactor setup for heterogeneous Grignard alkylation of a pharmaceutical intermediate
WO2002028941A3 (fr) Procedes de polymerisation continue en une seule phase ou en plusieurs phases
Guo et al. Continuous-flow synthesis of the nucleobase unit of remdesivir
EP2138500A1 (fr) Réactions du type grignard effectuées à des micro-réacteurs
WO2008012515A3 (fr) Appareil de réfrigération/chauffage
CN114432980B (zh) 一种微通道反应装置及其应用
KR20210040648A (ko) 의약품 생산증대를 위한 모듈 조립형 넘버링업 금속 마이크로반응기
Pieters et al. The impact of microtechnologies on chemical and pharmaceutical production processes
Lier et al. Modular process engineering: Development of apparatuses for transformable production systems

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001935559

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001935559

Country of ref document: EP