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WO2001089495A2 - Compositions antibiotiques destinees au traitement des yeux, oreilles et nez - Google Patents

Compositions antibiotiques destinees au traitement des yeux, oreilles et nez Download PDF

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Publication number
WO2001089495A2
WO2001089495A2 PCT/US2001/016107 US0116107W WO0189495A2 WO 2001089495 A2 WO2001089495 A2 WO 2001089495A2 US 0116107 W US0116107 W US 0116107W WO 0189495 A2 WO0189495 A2 WO 0189495A2
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WO
WIPO (PCT)
Prior art keywords
ophthalmic
otic
infections
microbacterium
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/016107
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English (en)
Other versions
WO2001089495A3 (fr
Inventor
Gerald Cagle
Robert L. Abshire
David W. Stroman
Celeste H. Mclean
Linda L. Clark
John M. Yanni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Priority to AU2001261748A priority Critical patent/AU2001261748A1/en
Publication of WO2001089495A2 publication Critical patent/WO2001089495A2/fr
Publication of WO2001089495A3 publication Critical patent/WO2001089495A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Definitions

  • the present invention is directed to the provision of topical antibiotic pharmaceutical compositions for the treatment of ophthalmic, otic and nasal infections, particularly bacterial infections, and to methods of treating ophthalmic, otic and nasal infections by applying those compositions to the affected tissues.
  • the compositions and methods of the invention are based on the use of a new class of antibiotics.
  • the compositions of the present invention may also contain one or more anti-inflammatory agents.
  • Quinolone antibiotics have been previously utilized to treat ophthalmic and otic infections.
  • a topical ophthalmic composition containing the quinolone ciprofloxacin is marketed by Alcon Laboratories, Inc. under the name CILOXANTM (Ciprofloxacin 0.3%) Ophthalmic Solution
  • a topical otic composition containing a combination of ciprofloxacin and hydrocortisone is marketed by Alcon Laboratories, Inc. under the name CIPROTM HC.
  • the following quinolones have also been utilized in ophthalmic antibiotic compositions:
  • quinolone antibiotic compositions are generally effective in treating ophthalmic infections, and have distinct advantages over prior ophthalmic antibiotic compositions, particularly those having relatively limited spectrums of antimicrobial activity, such as: neomycin, polymyxin B, gentamicin and tobramycin, which are primarily useful against gram negative pathogens; and bacitracin, gramicidin, and erythromycin, which are primarily active against gram positive pathogens.
  • Ophthalmic, otic and nasal infections are frequently accompanied by inflammation of the infected ophthalmic, otic and nasal tissues and perhaps even surrounding tissues.
  • ophthalmic, otic and nasal surgical procedures that create a risk of microbial infections frequently also cause inflammation of the affected tissues.
  • ophthalmic, otic and nasal pharmaceutical compositions that combine the anti- infective activity of one or more antibiotics with the anti- inflammatory activity of one or more steroid or non-steroid agents in a single composition.
  • the invention is based on the use of a potent new class of antibiotics to treat ophthalmic, otic and nasal infections, as well as the use of these antibiotics prior to surgery to sterilize the surgical field and prophylactically following surgery or other trauma to ophthalmic, otic or nasal tissues to minimize the risk of infection.
  • the compositions of the present invention may also be administered to the affected tissues during ophthalmic, otic or nasal surgical procedures to prevent or alleviate post-surgical infection.
  • the terms "treat”, “treating” and derivations thereof are intended to include both treatments of existing infections and treatments to prevent or reduce the risk of infections.
  • compositions preferably also contain one or more anti-inflammatory agents to treat inflammation associated with infections of ophthalmic, otic or nasal tissues.
  • the anti-inflammatory component of the compositions is also useful in treating inflammation associated with physical trauma to ophthalmic, otic or nasal tissues, including inflammation resulting from surgical procedures.
  • the compositions of the present invention are therefore particularly useful in treating inflammation associated with trauma to ophthalmic, otic or nasal tissues wherein there is either an infection or a risk of an infection resulting from the trauma.
  • compositions of the present invention examples include conjunctivitis, keratitis, blepharitis, dacyrocystitis, hordeolum and corneal ulcers.
  • the compositions of the invention may also be used prophylactically in connection with various ophthalmic surgical procedures that create a risk of infection.
  • compositions of the present invention examples include otitis externa and otitis media.
  • otitis media With respect to the treatment of otitis media, the compositions of the present invention are primarily useful in cases where the tympanic membrane has ruptured or tympanostomy tubes have been implanted.
  • the compositions may also be used to treat infections associated with otic surgical procedures, such as tympanostomy, or to prevent such infections.
  • compositions and methods of the present invention are particularly useful in the treatment of acute infections of the external ear canal, which are commonly referred to as "acute otitis externa” or "AOE".
  • AOE acute otitis externa
  • the present invention is based in part on the isolation of two bacterial species that have not previously been identified as pathogens relative to acute otitis externa infections. These bacterial species, which have been named “Microbacterium otitidis” and “Microbacterium alconae", are described in greater detail below.
  • the present invention is also based in part on a finding that the antibiotics utilized in the present invention, particularly Moxifloxacin, have a very high level of antimicrobial activity against these newly discovered pathogens, and therefore are particularly useful in the treatment of acute otitis externa infections involving these pathogens.
  • the two bacterial species that have been identified as being associated with acute otitis externa infections have also been discovered to be associated with ophthalmic infections.
  • the antibiotics utilized in the present invention have a high level of antimicrobial activity against these newly discovered ophthalmic pathogens, and as a result, the compositions of the present invention are particularly useful in treating ophthalmic infections involving these species.
  • compositions of the present invention are specially formulated for topical application to ophthalmic, otic and nasal tissues.
  • the compositions are preferably sterile, and have physical properties (e.g., osmolality and pH) that are specially suited for application to ophthalmic, otic and nasal tissues, including tissues that have been compromised as the result of preexisting disease, trauma, surgery or other physical conditions.
  • physical properties e.g., osmolality and pH
  • the antibiotics used in the compositions and methods of the present invention have the following formula:
  • A is CH, CF, CC1, C-OCH 3 , orN;
  • X 1 is H, halogen, NH 2 , or CH 3 ;
  • R 1 is to C 3 alkyl, FCH 2 CH 2 , cyclopropyl or phenyl, optionally mono-, di- or tri- substituted by halogen, or A and R) together can form a bridge of formula C-O- CH 2 -CH(CH 3 );
  • R 2 is H, C] to C 3 alkyl (optionally substituted by OH, halogen or NH 2 ), or 5- methyl-2-oxo- 1 ,3-dioxol-4-yl-methyl;
  • B is a selected from the group consisting of:
  • Y is O or CH 2 ;
  • R is H or to C 3 alkyl
  • R' is H or Ci to C 3 alkyl
  • Moxifloxacin has the following structure:
  • the concentrations of the antibiotics of formula (I) in the compositions of the present invention will vary depending on the intended use of the compositions (e.g., treatment of existing infections or prevention of post-surgical infections), and the relative antimicrobial activity of the specific antibiotic selected.
  • the antimicrobial activity of antibiotics is generally expressed as the minimum concentration required to inhibit the growth of a specified pathogen. This concentration is also referred to as the “minimum inhibitory concentration” or "MIC”.
  • MIC 90 refers to the minimum concentration of antibiotic required to inhibit the growth of ninety percent (90%) of the strains of a species.
  • the concentration of an antibiotic required to totally kill a specified bacteria is referred to as the "minimum bactericidal concentration" or "MBC”.
  • MBC minimum inhibitory concentration of Moxifloxacin for several bacteria commonly associated with ophthalmic, otic and nasal infections are provided in the following table:
  • the present invention is based in part on the identification of two bacterial species that are believed to act as pathogens in acute otitis externa infections, Microbacterium otitidis and Microbacterium alconae. These bacteria belong to the class known as "coryneforms" or “diphtheroids". Bacteria belonging to this class have been previously identified as being present both in healthy ears and in ears afflicted with acute otitis externa infections. However, prior to the present invention, there had been no species-level identification of the coryneform bacteria present either in healthy ears or infected ears, nor had there been any attempt to eradicate the pathogenic species present in acute otitis externa infections with antibiotic therapy keyed to those species.
  • the present inventors have now identified two species of coryneform bacteria as being present in acute otitis externa infections, and have determined that the compounds of formula (I), particularly Moxifloxacin, are very effective in eradicating these species.
  • Microbacterium otitidis and Microbacterium alconae have also been discovered to be pathogens in infections of ophthalmic tissues, such as conjunctivitis and blepharitis.
  • the compositions of the present invention are therefore particularly useful in treating ophthalmic infections involving one or both of these species.
  • the bacterial species referred to above were identified as a result of research conducted on specimens obtained from 2,122 ears afflicted with acute otitis externa infections and 82 healthy ears. Coryneform bacteria of some type were isolated from 10 to 30% of these ears overall; the incidence of finding this class of bacteria present varied depending on the season when the specimen was taken. Although coryneform bacteria have been identified previously in both healthy and infected ears, the present inventors have discovered that the coryneform bacteria present in healthy ears and in acute otitis externa ears are different. In the acute otitis externa ears, 80% of the coryneform bacteria identified belong to the genus Microbacterium, while in the healthy ears, 90% of the coryneform bacteria identified belong to the genus Turicella.
  • coryneform bacteria found in acute otitis externa patients include two species that have not previously been identified. These species are now identified as Microbacterium sp. nov. otitidis and Microbacterium sp. nov. alconae. These names for the species have been assigned by the inventors, but have not yet been officially published. The names utilized for these species below are ''Microbacterium otitidis” (sometimes abbreviated as "M otitidis”) and " Microbacterium alconae” (sometimes abbreviated as "M alconae”), respectively.
  • M. otitidis and M. alconae isolates were identified as being present, these species were the only type of bacteria recovered. Moreover, these species were not recovered from healthy ears.
  • M. otitidis and M. alconae are pathogens in acute otitis externa. That is, these species were either largely or totally responsible for the acute otitis externa infections in the ears from which they were isolated.
  • the above-cited findings are believed to represent the first frequent association of the genus Microbacterium with a human infectious disease, namely, acute otitis externa.
  • the two new Microbacterium species that have been discovered to be pathogens in acute otitis externa are described in greater detail below.
  • M. otitidis is most closely related to M. hominis
  • M. alconae is most closely related to M. maritypicum and M. liquefaciens.
  • the two new Microbacterium species have been characterized for taxomonic purposes using DNA methods as well as phenotypic methods.
  • the sequencing of the 16S rRNA gene showed that both sets of strains belonged to the genus Microbacterium, although the sequence differences from established Microbacterium species were significant enough to suggest novel species.
  • Automated ribotyping patterns further clarified the relationships (similarities and differences) with known Microbacterium species. These relationships are shown in Figure 1.
  • the above-cited analyses support the categorization of these bacteria as new species.
  • Both species of Microbacterium grow optimally at 28 - 30°C.
  • the M. otitidis isolates grow up to 37 ° C, while the M. alconae isolates grow up to 35°C.
  • the optimal growth temperature at 28 - 30°C is typical for bacteria that are normally found in water and soil.
  • M. otitidis isolates are most easily distinguished from M. hominis by their inability to metabolize: 1) N-acetyl-D-glucosamine, 2) 3-methyl glucose, 3) alaninamide, or 4) L-serine.
  • the isolates of M alconae can be distinguished from M. liquefaciens by their ability to metabolize: 1) amygdalin, 2) D-mannitol, 3) D- melezitose, 4) palatinose, 5) D-psicose, 6) salicin, 7) D-sorbitol, 8) D-xylose, or 9) p- hydoxyphenyl acetic acid.
  • M. liquefaciens by their ability to metabolize: 1) amygdalin, 2) D-mannitol, 3) D- melezitose, 4) palatinose, 5) D-psicose, 6) salicin, 7) D-sorbitol
  • alconae can be distinguished from M. maritypicum by their ability to metabolize: 1) amygdalin or 2) D-xylose, and can be distinguished from M. maritypicum by their inability to metabolize: 1) L-fucose.
  • Analysis of cellular fatty acids for the M. otitidis isolates showed the three major fatty acids to be: 1) 17:0 anteiso - 60%, 2) 15:0 anteiso - 26%, and 3) 16:0 iso - 11%.
  • Analysis of the M. alconae isolates showed the three major fatty acids to be: 1) 15:0 anteiso - 55%, 2) 17:0 anteiso - 23%, and 3) 16:0 iso - 11%.
  • the appropriate antibiotic concentration for ophthalmic compositions will generally be an amount of one or more antibiotics of formula (I) sufficient to provide a concentration in the aqueous humor and lacrimal fluid of the eye equal to or greater than the MIC 90 level for the selected antibiotic(s), relative to gram-negative and gram-positive organisms commonly associated with ophthalmic infections.
  • the appropriate concentration for otic and nasal compositions will generally be an amount of one or more antibiotics of formula (I) sufficient to provide a concentration in the infected tissues equal to or greater than the MIC 90 level for the selected antibiotic(s), relative to gram- negative and gram-positive organisms commonly associated with otic or nasal infections. Such amounts are referred to herein as "an antimicrobial effective amount”.
  • the compositions of the present invention will typically contain one or more compounds of formula (I) in a concentration of from about 0.1 to about 1.0 percent by weight (“wt. %”) of the compositions.
  • compositions of the present invention may also contain one or more anti- inflammatory agents.
  • the anti-inflammatory agents utilized in the present invention are broadly classified as steroidal or non-steroidal.
  • the preferred steroidal anti-inflammatory agents are glucocorticoids.
  • the preferred glucocorticoids for ophthalmic and otic use include dexamethasone, loteprednol, rimexolone, prednisolone, fluorometholone, and hydrocortisone.
  • the preferred glucocorticoids for nasal use include mometasone, fluticasone, beclomethasone, flunisolide, triamcinolone and budesonide.
  • dexamethasone derivatives described in U.S. Patent No. 5,223,493 are also preferred steroidal anti-inflammatory agents, particularly with respect to compositions for treating ophthalmic inflammation.
  • the following compounds are especially preferred:
  • 21 -ether derivatives of dexamethasone are referred to herein as "21 -ether derivatives of dexamethasone".
  • the 21-benzyl ether derivative i.e., compound AL-2512 is particularly preferred.
  • the preferred non-steroidal anti-inflammatory agents are: prostaglandin H synthetase inhibitors (Cox I or Cox II), also referred to as cyclooxygenase type I and type
  • inhibitors such as diclofenac, flurbiprofen, ketorolac, suprofen, nepafenac, amfenac, indomethacin, naproxen, ibuprofen, bromfenac, ketoprofen, meclofenamate, piroxicam, sulindac, mefanamic acid, diflusinal, oxaprozin, tolmetin, fenoprofen, benoxaprofen, nabumetome, etodolac, phenylbutazone, aspirin, oxyphenbutazone, NCX-4016, HCT-1026, NCX-284, NCX-456, tenoxicam and carprofen; cyclooxygenase type II selective inhibitors, such as NS-398, vioxx, celecoxib, P54, etodolac, L-804600 and S-
  • PAF antagonists such as SR-27417, A-137491, ABT-299, apafant, bepafant, minopafant, E-6123, BN-50727, nupafant and modipafant
  • PDE IV inhibitors such as ariflo, torbafylline, rolipram, filaminast, piclamilast, cipamfylline, CG-1088, V-11294A, CT-2820, PD-168787, CP-293121, DWP-205297, CP-220629, SH-636, BAY-19-8004, and roflumilast
  • inhibitors of cytokine production such as inhibitors of the NFkB transcription factor
  • other anti-inflammatory agents known to those skilled in the art.
  • compositions of the present invention will vary based on the agent or agents selected and the type of inflammation being treated. The concentrations will be sufficient to reduce inflammation in the targeted ophthalmic, otic or nasal tissues following topical application of the compositions to those tissues. Such an amount is referred to herein as "an anti- inflammatory effective amount”.
  • the compositions of the present invention will typically contain one or more anti-inflammatory agents in an amount of from about 0.01 to about 1.0 wt.%.
  • compositions are typically administered to the affected ophthalmic, otic or nasal tissues by topically applying one to four drops of a sterile solution or suspension, or a comparable amount of an ointment, gel or other solid or semisolid composition, one to four times per day.
  • the compositions may also be formulated as irrigating solutions that are applied to the affected ophthalmic, otic or nasal tissues during surgical procedures.
  • the ophthalmic, otic and nasal compositions of the present invention will contain one or more compounds of formula (I) and preferably one or more anti-inflammatory agents, in pharmaceutically acceptable vehicles.
  • the compositions will typically have a pH in the range of 4.5 to 8.0.
  • the ophthalmic compositions must also be formulated to have osmotic values that are compatible with the aqueous humor of the eye and ophthalmic tissues. Such osmotic values will generally be in the range of from about 200 to about 400 milliosmoles per kilogram of water (“mOsm/kg”), but will preferably be about 300 mOsm/kg.
  • Ophthalmic, otic and nasal pharmaceutical products are typically packaged in multidose form.
  • Preservatives are thus required to prevent microbial contamination during use.
  • Suitable preservatives include: polyquaternium-1, benzalkonium chloride, thimerosal, chlorobutanol, methyl paraben, propyl paraben, phenylethyl alcohol, edetate disodium, sorbic acid, or other agents known to those skilled in the art.
  • the use of polyquaternium-1 as the antimicrobial preservative is preferred.
  • such preservatives are employed at a level of from 0.001% to 1.0% by weight.
  • the solubility of the components of the present compositions may be enhanced by a surfactant or other appropriate co-solvent in the composition.
  • co-solvents include polysorbate 20, 60, and 80, polyoxyethylene/polyoxypropylene surfactants (e.g., Pluronic F-68, F-84 and P-103), cyclodextrin, or other agents known to those skilled in the art.
  • co-solvents are employed at a level of from 0.01% to 2% by weight.
  • viscosity enhancing agents to provide the compositions of the invention with viscosities greater than the viscosity of simple aqueous solutions may be desirable to increase ocular absorption of the active compounds by the target tissues or increase the retention time in the eye, ear or nose.
  • viscosity building agents include, for example, polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, hydroxy propyl methylcellulose, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxy propyl cellulose or other agents know to those skilled in the art. Such agents are typically employed at a level of from 0.01% to 2% by weight.
  • MCC Merobiology Culture Collection

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Abstract

L'invention concerne des compositions ophtalmiques, otiques et nasales renfermant une nouvelle classe d'antibiotiques (par exemple, la moxifloxacine). Les compositions renferment également, de préférence, un ou plusieurs agents anti-inflammatoires et peuvent être utilisées pour traiter des affections ophtalmiques, otiques et nasales par l'application topique de celles-ci sur les tissus affectés. Les compositions et procédés selon l'invention sont particulièrement utiles dans le traitement d'infections liées à une otite externe aiguë et d'infections ophtalmiques pouvant être attribuées à une des deux espèces de Microbacterium récemment identifiées,Microbacterium otitidis et Microbacterium alconae. ou à ces deux espèces.
PCT/US2001/016107 2000-05-19 2001-05-17 Compositions antibiotiques destinees au traitement des yeux, oreilles et nez Ceased WO2001089495A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001261748A AU2001261748A1 (en) 2000-05-19 2001-05-17 Antibiotic compositions for treatment of the eye, ear and nose

Applications Claiming Priority (2)

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US57726200A 2000-05-19 2000-05-19
US09/577,262 2000-05-19

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WO2001089495A2 true WO2001089495A2 (fr) 2001-11-29
WO2001089495A3 WO2001089495A3 (fr) 2002-05-30

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001089496A3 (fr) * 2000-05-19 2002-04-25 Alcon Lab Inc Compositions antibiotiques destinees au traitement des yeux, oreilles et nez
US6740664B2 (en) 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
WO2008137444A1 (fr) * 2007-05-01 2008-11-13 Alcon Research, Ltd. Formulations d'acides aminés n-halogénés avec des composés anti-inflammatoires
WO2009070530A1 (fr) * 2007-11-27 2009-06-04 Alcon Research, Ltd. Formulations de solutions topiques ophtalmiques ou otiques contenant du chlorhydrate de moxifloxacine et du phosphate de dexaméthasone
WO2009061607A3 (fr) * 2007-11-05 2009-07-02 Bausch & Lomb Matières non miscibles à l'eau en tant que véhicules pour l'administration d'un médicament
US7671070B2 (en) 1998-09-30 2010-03-02 Alcon, Inc. Method of treating ophthalmic infections with moxifloxacin compositions
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US8084445B2 (en) 2004-08-13 2011-12-27 Schering-Plough Animal Health Corporation Pharmaceutical formulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234078A1 (de) * 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
AR020661A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6740664B2 (en) 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
US8993636B2 (en) 1998-09-30 2015-03-31 Alcon Pharamceuticals, Ltd. Compositions containing moxifloxacin for treating otic infections
US8673902B2 (en) 1998-09-30 2014-03-18 Alcon Pharmaceuticals, Ltd. Method of treating otic infections with moxifloxacin compositions
US7671070B2 (en) 1998-09-30 2010-03-02 Alcon, Inc. Method of treating ophthalmic infections with moxifloxacin compositions
WO2001089496A3 (fr) * 2000-05-19 2002-04-25 Alcon Lab Inc Compositions antibiotiques destinees au traitement des yeux, oreilles et nez
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US8084445B2 (en) 2004-08-13 2011-12-27 Schering-Plough Animal Health Corporation Pharmaceutical formulation
WO2008137444A1 (fr) * 2007-05-01 2008-11-13 Alcon Research, Ltd. Formulations d'acides aminés n-halogénés avec des composés anti-inflammatoires
JP2011502990A (ja) * 2007-11-05 2011-01-27 ボーシュ アンド ローム インコーポレイティド 薬物送達用ビヒクルとしての水非混和性物質
WO2009061607A3 (fr) * 2007-11-05 2009-07-02 Bausch & Lomb Matières non miscibles à l'eau en tant que véhicules pour l'administration d'un médicament
US7888370B2 (en) 2007-11-27 2011-02-15 Alcon Research, Ltd. Topical ophthalmic or otic solution formulations containing moxifloxacin hydrochloride and dexamethasone phosphate
US8173671B2 (en) 2007-11-27 2012-05-08 Alcon Research, Ltd. Topical ophthalmic or otic solution formulations containing moxifloxacin hydrochloride and dexamethasone phosphate
WO2009070530A1 (fr) * 2007-11-27 2009-06-04 Alcon Research, Ltd. Formulations de solutions topiques ophtalmiques ou otiques contenant du chlorhydrate de moxifloxacine et du phosphate de dexaméthasone

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AU2001261748A1 (en) 2001-12-03
WO2001089495A3 (fr) 2002-05-30

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