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WO2001088155A3 - 33428, a human metalloprotease family member and uses thereof - Google Patents

33428, a human metalloprotease family member and uses thereof Download PDF

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Publication number
WO2001088155A3
WO2001088155A3 PCT/US2001/015527 US0115527W WO0188155A3 WO 2001088155 A3 WO2001088155 A3 WO 2001088155A3 US 0115527 W US0115527 W US 0115527W WO 0188155 A3 WO0188155 A3 WO 0188155A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
metalloprotease family
expression vectors
family member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/015527
Other languages
French (fr)
Other versions
WO2001088155A2 (en
Inventor
Rosana Kapeller-Libermann
William James Cook
Inmaculada Silos-Santiago
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU2001261570A priority Critical patent/AU2001261570A1/en
Publication of WO2001088155A2 publication Critical patent/WO2001088155A2/en
Publication of WO2001088155A3 publication Critical patent/WO2001088155A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 33428 nucleic acid molecules, which encode novel metalloprotease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33428 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33428 gene has been introduced or disrupted. The invention still further provides isolated 33428 proteins, fusion proteins, antigenic peptides and anti-33428 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/015527 2000-05-15 2001-05-15 33428, a human metalloprotease family member and uses thereof Ceased WO2001088155A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001261570A AU2001261570A1 (en) 2000-05-15 2001-05-15 33428, a novel human metalloprotease family member and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20415900P 2000-05-15 2000-05-15
US20416000P 2000-05-15 2000-05-15
US60/204,160 2000-05-15
US60/204,159 2000-05-15

Publications (2)

Publication Number Publication Date
WO2001088155A2 WO2001088155A2 (en) 2001-11-22
WO2001088155A3 true WO2001088155A3 (en) 2002-04-04

Family

ID=26899237

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/015527 Ceased WO2001088155A2 (en) 2000-05-15 2001-05-15 33428, a human metalloprotease family member and uses thereof
PCT/US2001/015766 Ceased WO2001088156A2 (en) 2000-05-15 2001-05-15 33428, a human metalloprotease family member and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015766 Ceased WO2001088156A2 (en) 2000-05-15 2001-05-15 33428, a human metalloprotease family member and uses thereof

Country Status (3)

Country Link
EP (1) EP1290195A2 (en)
AU (2) AU2001261570A1 (en)
WO (2) WO2001088155A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055643A1 (en) * 1997-06-03 1998-12-10 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein
JP2001008687A (en) * 1999-06-25 2001-01-16 Yamanouchi Pharmaceut Co Ltd Novel metal protease and its gene
WO2001011074A2 (en) * 1999-08-06 2001-02-15 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
WO2001023561A2 (en) * 1999-09-27 2001-04-05 Curagen Corporation Novel polynucleotides encoding proteins containing thrombospondin type 1 repeats
DE10107360A1 (en) * 2000-02-18 2001-09-06 Hoffmann La Roche Novel metalloprotease containing a thrombospondin domain (MPTS protein) is useful to treat aggrecan associated disease including rheumatoid arthritis and osteoarthritis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055643A1 (en) * 1997-06-03 1998-12-10 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein
EP1004674A1 (en) * 1997-06-03 2000-05-31 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein
JP2001008687A (en) * 1999-06-25 2001-01-16 Yamanouchi Pharmaceut Co Ltd Novel metal protease and its gene
WO2001011074A2 (en) * 1999-08-06 2001-02-15 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
WO2001023561A2 (en) * 1999-09-27 2001-04-05 Curagen Corporation Novel polynucleotides encoding proteins containing thrombospondin type 1 repeats
DE10107360A1 (en) * 2000-02-18 2001-09-06 Hoffmann La Roche Novel metalloprotease containing a thrombospondin domain (MPTS protein) is useful to treat aggrecan associated disease including rheumatoid arthritis and osteoarthritis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST EMBL; 17 September 1999 (1999-09-17), NCI-CGAP: "wv74h06.x1 Soares_thymus_NHFTh Homo sapiens cDNA clone IMAGE:2535323 3' similar to TR:O60345 O60345 KIAA0605 PROTEIN. ;, mRNA sequence.", XP002186998 *
DATABASE EM_EST EMBL; 19 May 1999 (1999-05-19), NCI-CGAP: "we60a01.x1 Soares_thymus_NHFTh Homo sapiens cDNA clone IMAGE:2345448 3' similar to TR:O54768 O54768 A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS ;contains TAR1.t1 TAR1 repetitive element ;, mRNA sequence.", XP002187000 *
DATABASE EM_EST EMBL; 23 September 1998 (1998-09-23), NCI-CGAP: "qb82f12.x1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:1706639 3' similar to WP:F25H8.3 CE05729 THROMBOSPONDIN LIKE ;contains TAR1.t1 TAR1 repetitive element ;, mRNA sequence.", XP002186999 *
DATABASE WPI Section Ch Week 200130, Derwent World Patents Index; Class B04, AN 2001-285362, XP002187001 *
FRANCISCA VÁZQUEZ ET AL: "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23349 - 23357, XP002141414, ISSN: 0021-9258 *
HURSKAINEN TIINA L ET AL: "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: General features and genomic distribution of the Adam-TS family", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 36, 3 September 1999 (1999-09-03), pages 25555 - 25563, XP002158991, ISSN: 0021-9258 *
NAGASE TAKAHIRO ET AL: "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vivo", DNA RESEARCH, vol. 5, no. 1, 1998, pages 31 - 39, XP000878819, ISSN: 1340-2838 *
PROCKOP DARWIN J ET AL: "Procollagen N-proteinase and procollagen C-proteinase: Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling.", MATRIX BIOLOGY, vol. 16, no. 7, February 1998 (1998-02-01), pages 399 - 408, XP001042352, ISSN: 0945-053X *
TANG BOR L ET AL: "ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats", FEBS LETTERS, vol. 445, no. 2-3, 26 February 1999 (1999-02-26), pages 223 - 225, XP004259261, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
AU2001261570A1 (en) 2001-11-26
WO2001088155A2 (en) 2001-11-22
WO2001088156A3 (en) 2002-03-28
WO2001088156A2 (en) 2001-11-22
AU2001261651A1 (en) 2001-11-26
EP1290195A2 (en) 2003-03-12

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