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WO2001085956A3 - Lipid metabolism enzymes - Google Patents

Lipid metabolism enzymes Download PDF

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Publication number
WO2001085956A3
WO2001085956A3 PCT/US2001/015210 US0115210W WO0185956A3 WO 2001085956 A3 WO2001085956 A3 WO 2001085956A3 US 0115210 W US0115210 W US 0115210W WO 0185956 A3 WO0185956 A3 WO 0185956A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid metabolism
lme
metabolism enzymes
provides
polynucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/015210
Other languages
French (fr)
Other versions
WO2001085956A2 (en
Inventor
Debopriya Das
Roopa Reddy
Monique G Yao
Danniel B Nguyen
Yan Lu
Catherine M Tribouley
Henry Yue
Farrah A Khan
Ameena R Gandhi
Janice Au-Young
Preeti Lal
Liam Kearney
Vicki S Elliott
Li Ding
Michael Thornton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to US10/275,998 priority Critical patent/US20040023354A1/en
Priority to CA002407864A priority patent/CA2407864A1/en
Priority to JP2001582545A priority patent/JP2004513611A/en
Priority to EP01935320A priority patent/EP1280918A2/en
Priority to AU2001261424A priority patent/AU2001261424A1/en
Publication of WO2001085956A2 publication Critical patent/WO2001085956A2/en
Publication of WO2001085956A3 publication Critical patent/WO2001085956A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LME.
PCT/US2001/015210 2000-05-11 2001-05-11 Lipid metabolism enzymes Ceased WO2001085956A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/275,998 US20040023354A1 (en) 2001-05-11 2001-05-11 Lipid metabolism enzymes
CA002407864A CA2407864A1 (en) 2000-05-11 2001-05-11 Lipid metabolism enzymes
JP2001582545A JP2004513611A (en) 2000-05-11 2001-05-11 Lipid metabolizing enzymes
EP01935320A EP1280918A2 (en) 2000-05-11 2001-05-11 Lipid metabolism enzymes
AU2001261424A AU2001261424A1 (en) 2000-05-11 2001-05-11 Lipid metabolism enzymes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US20351100P 2000-05-11 2000-05-11
US60/203,511 2000-05-11
US20790300P 2000-05-25 2000-05-25
US60/207,903 2000-05-25
US21015000P 2000-06-07 2000-06-07
US60/210,150 2000-06-07
US21339200P 2000-06-23 2000-06-23
US60/213,392 2000-06-23

Publications (2)

Publication Number Publication Date
WO2001085956A2 WO2001085956A2 (en) 2001-11-15
WO2001085956A3 true WO2001085956A3 (en) 2002-09-19

Family

ID=27498501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015210 Ceased WO2001085956A2 (en) 2000-05-11 2001-05-11 Lipid metabolism enzymes

Country Status (5)

Country Link
EP (1) EP1280918A2 (en)
JP (1) JP2004513611A (en)
AU (1) AU2001261424A1 (en)
CA (1) CA2407864A1 (en)
WO (1) WO2001085956A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090323A2 (en) * 2000-05-19 2001-11-29 Millennium Pharmaceuticals, Inc. 46638, a putative family member of human lipoxygenase
US6812017B2 (en) 2000-10-11 2004-11-02 Centre National De La Recherche Scientique - Cnrs Mammalian secreted group IIF phospholipase A2
US6897056B2 (en) 2000-11-08 2005-05-24 Millennium Pharmaceuticals, Inc. 32544, a novel human phospholipase C and uses thereof
WO2003033689A1 (en) * 2001-10-12 2003-04-24 Centre National De La Recherche Scientifique -Cnrs- Cloning and recombinant expression of mammalian secreted group iif phopholipase a2

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0731164A1 (en) * 1993-09-24 1996-09-11 Shionogi & Co., Ltd. HUMAN PHOSPHOLIPASE C-$g(a) AND DNA SEQUENCE CODING FOR THE SAME
WO2001073027A2 (en) * 2000-03-24 2001-10-04 Corixa Corporation Compositions and methods for therapy and diagnosis of colon cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0731164A1 (en) * 1993-09-24 1996-09-11 Shionogi & Co., Ltd. HUMAN PHOSPHOLIPASE C-$g(a) AND DNA SEQUENCE CODING FOR THE SAME
WO2001073027A2 (en) * 2000-03-24 2001-10-04 Corixa Corporation Compositions and methods for therapy and diagnosis of colon cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALVAREZ RICHARD A ET AL: "CDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase C-beta-4 (PLCB4).", GENOMICS, vol. 29, no. 1, 1995, pages 53 - 61, XP001064391, ISSN: 0888-7543 *
DATABASE EMBL 12 June 1993 (1993-06-12), FERREIRA P A ET AL: "Bovine phospholipase C mRNA, 3' end of cds.", XP002193223 *
DATABASE EMBL 21 April 1995 (1995-04-21), ALVAREZ R A ET AL: "Homo sapiens phospholipase C beta 4 (PLCB4) mRNA, complete cds.", XP002193222 *
DATABASE EMBL 4 October 1993 (1993-10-04), LEE C W ET AL: "Rattus norvegicus phospholipase C beta4 mRNA, complete cds.", XP002193224 *
FERREIRA PAULO A ET AL: "Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 13, 1993, 1993, pages 6042 - 6046, XP002193221, ISSN: 0027-8424 *
LEE C-W ET AL: "PURIFICATION, MOLECULAR CLONING, AND SEQUENCING OF PHOSPHOLIPASE C-BETA4", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 268, no. 28, 5 October 1993 (1993-10-05), pages 21318 - 21327, XP002013539, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1280918A2 (en) 2003-02-05
WO2001085956A2 (en) 2001-11-15
AU2001261424A1 (en) 2001-11-20
JP2004513611A (en) 2004-05-13
CA2407864A1 (en) 2001-11-15

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