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WO2001085131A3 - Compositions d'excipient a base de lipides pour retention medicamenteuse amelioree - Google Patents

Compositions d'excipient a base de lipides pour retention medicamenteuse amelioree Download PDF

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Publication number
WO2001085131A3
WO2001085131A3 PCT/CA2001/000655 CA0100655W WO0185131A3 WO 2001085131 A3 WO2001085131 A3 WO 2001085131A3 CA 0100655 W CA0100655 W CA 0100655W WO 0185131 A3 WO0185131 A3 WO 0185131A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved drug
mol
drug retention
retention
liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2001/000655
Other languages
English (en)
Other versions
WO2001085131A2 (fr
Inventor
Lawrence D Mayer
Dos Nancy Santos
Marcel B Bally
Murray Webb
Paul Tardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CELATOR TECHNOLOGIES Inc
Original Assignee
CELATOR TECHNOLOGIES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CELATOR TECHNOLOGIES Inc filed Critical CELATOR TECHNOLOGIES Inc
Priority to AU2001258106A priority Critical patent/AU2001258106A1/en
Publication of WO2001085131A2 publication Critical patent/WO2001085131A2/fr
Publication of WO2001085131A3 publication Critical patent/WO2001085131A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des liposomes sensiblement exempts de cholestérol présentant une rétention médicamenteuse in vivo améliorée. Ces liposomes comprennent: (a) au moins 60 moles % d'un phospholipide comprenant deux acides gras saturés, la chaîne acyl de chacun étant identique ou différente, au moins une des deux chaînes acyl présentant plus de 18 atomes de carbone; (b) des lipides conjugués à des polymères hydrophiles représentant entre environ 2 et environ 15 moles %; et (c) jusqu'à 38 moles % d'au moins un lipide formant une vésicule. Des modes de réalisation spécifiques de la présente invention concerne des liposomes encapsulant de l'idarubicine ou du topotécan et présentant une rétention médicamenteuse améliorée. L'invention concerne également un procédé permettant de déterminer si une rétention d'un médicament particulier peut être améliorée par la présente invention.
PCT/CA2001/000655 2000-05-11 2001-05-11 Compositions d'excipient a base de lipides pour retention medicamenteuse amelioree Ceased WO2001085131A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001258106A AU2001258106A1 (en) 2000-05-11 2001-05-11 Lipid carrier compositions for improved drug retention

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20339900P 2000-05-11 2000-05-11
US60/203,399 2000-05-11

Publications (2)

Publication Number Publication Date
WO2001085131A2 WO2001085131A2 (fr) 2001-11-15
WO2001085131A3 true WO2001085131A3 (fr) 2002-04-25

Family

ID=22753830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000655 Ceased WO2001085131A2 (fr) 2000-05-11 2001-05-11 Compositions d'excipient a base de lipides pour retention medicamenteuse amelioree

Country Status (2)

Country Link
AU (1) AU2001258106A1 (fr)
WO (1) WO2001085131A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002331481B2 (en) 2001-10-03 2008-04-24 Celator Pharmaceuticals, Inc. Liposome loading with metal ions
US20060193902A1 (en) * 2003-04-02 2006-08-31 Celator Pharmaceuticals, Inc. Pharmaceutical compositions containing active agents having a lactone group and transition metal ions
EP1796729A4 (fr) * 2004-10-06 2010-12-08 Bc Cancer Agency Liposomes permettant une meilleure retention du medicament, destines au traitement du cancer
AU2005304914B2 (en) 2004-11-05 2012-02-16 Tekmira Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations
EA201070296A1 (ru) * 2007-08-21 2010-08-30 Алза Корпорейшн Липосомные композиции для введения in vivo соединений бороновой кислоты
US10980798B2 (en) 2011-11-03 2021-04-20 Taiwan Liposome Company, Ltd. Pharmaceutical compositions of hydrophobic camptothecin derivatives
US10391056B2 (en) 2011-11-03 2019-08-27 Taiwan Lipsome Company, LTD. Pharmaceutical compositions of hydrophobic camptothecin derivatives
WO2014054026A1 (fr) * 2012-10-04 2014-04-10 University Of The Witwatersrand, Johannesburg Système d'administration de médicament liposomal

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5213804A (en) * 1989-10-20 1993-05-25 Liposome Technology, Inc. Solid tumor treatment method and composition
WO1993019738A1 (fr) * 1992-03-27 1993-10-14 Liposome Technology, Inc. Methode de traitement de tissus infectes
WO1998034597A1 (fr) * 1997-02-06 1998-08-13 Duke University Liposomes renfermant des agents actifs
WO2000023052A1 (fr) * 1998-09-16 2000-04-27 Alza Corporation Inhibiteurs de topoisomerase pieges dans des liposomes
US6171613B1 (en) * 1996-10-01 2001-01-09 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5213804A (en) * 1989-10-20 1993-05-25 Liposome Technology, Inc. Solid tumor treatment method and composition
WO1993019738A1 (fr) * 1992-03-27 1993-10-14 Liposome Technology, Inc. Methode de traitement de tissus infectes
US6171613B1 (en) * 1996-10-01 2001-01-09 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
WO1998034597A1 (fr) * 1997-02-06 1998-08-13 Duke University Liposomes renfermant des agents actifs
WO2000023052A1 (fr) * 1998-09-16 2000-04-27 Alza Corporation Inhibiteurs de topoisomerase pieges dans des liposomes

Also Published As

Publication number Publication date
AU2001258106A1 (en) 2001-11-20
WO2001085131A2 (fr) 2001-11-15

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