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WO2001085027A3 - Procede et appareil destines a etre utilises avec une electrode active et un catheter d'administration de medicaments - Google Patents

Procede et appareil destines a etre utilises avec une electrode active et un catheter d'administration de medicaments Download PDF

Info

Publication number
WO2001085027A3
WO2001085027A3 PCT/US2001/014524 US0114524W WO0185027A3 WO 2001085027 A3 WO2001085027 A3 WO 2001085027A3 US 0114524 W US0114524 W US 0114524W WO 0185027 A3 WO0185027 A3 WO 0185027A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
drug
imaging
delivery
active electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/014524
Other languages
English (en)
Other versions
WO2001085027A2 (fr
Inventor
John Kucharczyk
Michael E Moseley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Image Guided Neurologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/566,798 external-priority patent/US7505807B1/en
Application filed by Image Guided Neurologics Inc filed Critical Image Guided Neurologics Inc
Priority to EP01931071A priority Critical patent/EP1280456A2/fr
Publication of WO2001085027A2 publication Critical patent/WO2001085027A2/fr
Publication of WO2001085027A3 publication Critical patent/WO2001085027A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M2025/0166—Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne un appareil et un procédé de traitement et d'administration ciblée de médicaments sur un patient vivant, notamment mais non exclusivement en utilisant l'imagerie par résonance magnétique. Cet appareil et ce procédé, qui conviennent pour l'administration de tous types de tissus vivants, font appel à l'imagerie par résonance magnétique afin de suivre les médicaments administrés et d'en estimer la vitesse. Un dispositif d'administration de médicaments visible par résonance magnétique positionné sur un site cible (par exemple, administration intracrânienne) administre au tissu (par exemple, le cerveau) une solution médicamenteuse diagnostique ou thérapeutique. La cinétique de distribution spatiale de l'agent médicamenteux injecté ou infusé est surveillée de manière quantitative et non invasive en utilisant l'imagerie par résonance magnétique à diffusion directionnelle protonique par l'eau afin de déterminer l'efficacité de l'administration de médicaments sur un point ciblé.
PCT/US2001/014524 2000-05-08 2001-05-04 Procede et appareil destines a etre utilises avec une electrode active et un catheter d'administration de medicaments Ceased WO2001085027A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP01931071A EP1280456A2 (fr) 2000-05-08 2001-05-04 Procede et appareil destines a etre utilises avec une electrode active et un catheter d'administration de medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/566,798 US7505807B1 (en) 1997-05-15 2000-05-08 Magnetic resonance apparatus for use with active electrode and drug deliver catheter
US09/566,798 2000-05-08

Publications (2)

Publication Number Publication Date
WO2001085027A2 WO2001085027A2 (fr) 2001-11-15
WO2001085027A3 true WO2001085027A3 (fr) 2002-04-25

Family

ID=24264414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014524 Ceased WO2001085027A2 (fr) 2000-05-08 2001-05-04 Procede et appareil destines a etre utilises avec une electrode active et un catheter d'administration de medicaments

Country Status (2)

Country Link
EP (1) EP1280456A2 (fr)
WO (1) WO2001085027A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9008761B2 (en) 2010-02-01 2015-04-14 Proteus Digital Health, Inc. Two-wrist data gathering system
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1788498A1 (fr) * 2005-11-21 2007-05-23 BrainLAB AG Appareil pour l'infusion de substances
EP2037999B1 (fr) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Système d'administration parentérale intelligent
AU2008304622B2 (en) * 2007-09-24 2013-03-14 Boston Scientific Limited MRI phase visualization of interventional devices
US9731122B2 (en) 2013-04-29 2017-08-15 Rainbow Medical Ltd. Electroosmotic tissue treatment
US9616221B2 (en) 2015-07-08 2017-04-11 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease
US9724515B2 (en) 2015-10-29 2017-08-08 Rainbow Medical Ltd. Electrical substance clearance from the brain for treatment of Alzheimer's disease
US10898716B2 (en) 2015-10-29 2021-01-26 Rainbow Medical Ltd. Electrical substance clearance from the brain
US9950156B2 (en) 2016-09-13 2018-04-24 Rainbow Medical Ltd. Disc therapy
US9770591B2 (en) 2015-12-29 2017-09-26 Rainbow Medical Ltd. Disc therapy
US10518085B2 (en) 2015-12-29 2019-12-31 Rainbow Medical Ltd. Disc therapy
US11484706B2 (en) 2015-12-29 2022-11-01 Discure Technologies Ltd Disc therapy
US10569086B2 (en) 2017-01-11 2020-02-25 Rainbow Medical Ltd. Electrical microglial cell activation
US10758722B2 (en) 2017-05-03 2020-09-01 Rainbow Medical Ltd. Electrical treatment of Parkinson's disease
US11202905B2 (en) 2018-03-14 2021-12-21 Rainbow Medical Ltd. Electrical substance clearance from the brain
WO2020252750A1 (fr) * 2019-06-20 2020-12-24 Shanghai United Imaging Healthcare Co., Ltd. Système et procédé de radiothérapie
US11123197B2 (en) 2019-09-03 2021-09-21 Rainbow Medical Ltd. Hydropneumatic artificial intervertebral disc
US10881858B1 (en) 2019-09-18 2021-01-05 Rainbow Medical Ltd. Electrical substance clearance from the brain
US11298530B1 (en) 2021-05-03 2022-04-12 Discure Technologies Ltd. Synergistic therapies for intervertebral disc degeneration
US11344721B1 (en) 2021-08-16 2022-05-31 Rainbow Medical Ltd. Cartilage treatment
US11413455B1 (en) 2022-02-08 2022-08-16 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease
US12208267B1 (en) 2024-04-19 2025-01-28 Yossi Gross Blood flow enhancement therapy system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468636A1 (fr) * 1990-06-18 1992-01-29 Boaz Avitall Système implantable de débit iontophorétique
US5647361A (en) * 1992-09-28 1997-07-15 Fonar Corporation Magnetic resonance imaging method and apparatus for guiding invasive therapy
US5893881A (en) * 1995-09-08 1999-04-13 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain by delivering a bolus of analgesic
US5925066A (en) * 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5964705A (en) * 1997-08-22 1999-10-12 Image-Guided Drug Delivery System, Inc. MR-compatible medical devices

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403138D0 (en) 1984-02-07 1984-03-14 Graham N B Sustained release of active ingredient
US4824436A (en) 1985-04-09 1989-04-25 Harvey Wolinsky Method for the prevention of restenosis
US5017566A (en) 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5226902A (en) 1991-07-30 1993-07-13 University Of Utah Pulsatile drug delivery device using stimuli sensitive hydrogel
US5344402A (en) 1993-06-30 1994-09-06 Cardiovascular Dynamics, Inc. Low profile perfusion catheter
US5514092A (en) 1994-08-08 1996-05-07 Schneider (Usa) Inc. Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468636A1 (fr) * 1990-06-18 1992-01-29 Boaz Avitall Système implantable de débit iontophorétique
US5647361A (en) * 1992-09-28 1997-07-15 Fonar Corporation Magnetic resonance imaging method and apparatus for guiding invasive therapy
US5893881A (en) * 1995-09-08 1999-04-13 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain by delivering a bolus of analgesic
US5925066A (en) * 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5964705A (en) * 1997-08-22 1999-10-12 Image-Guided Drug Delivery System, Inc. MR-compatible medical devices

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US9008761B2 (en) 2010-02-01 2015-04-14 Proteus Digital Health, Inc. Two-wrist data gathering system
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system

Also Published As

Publication number Publication date
EP1280456A2 (fr) 2003-02-05
WO2001085027A2 (fr) 2001-11-15

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