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WO2001082916A3 - Compositions therapeutiques combinees et leurs methodes d'utilisation - Google Patents

Compositions therapeutiques combinees et leurs methodes d'utilisation Download PDF

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Publication number
WO2001082916A3
WO2001082916A3 PCT/US2001/014393 US0114393W WO0182916A3 WO 2001082916 A3 WO2001082916 A3 WO 2001082916A3 US 0114393 W US0114393 W US 0114393W WO 0182916 A3 WO0182916 A3 WO 0182916A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
antidiabetic agent
methods
delivered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/014393
Other languages
English (en)
Other versions
WO2001082916A2 (fr
Inventor
Juan C Jaen
Jin-Long Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tularik Inc
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Priority to AU6118001A priority Critical patent/AU6118001A/xx
Publication of WO2001082916A2 publication Critical patent/WO2001082916A2/fr
Publication of WO2001082916A3 publication Critical patent/WO2001082916A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des compositions pharmaceutiques et des méthodes destinées au traitement du diabète sucré à l'aide d'une polythérapie. Ces compositions correspondent à un composé de formule (I) et à un agent antidiabétique tel que des sulfonylurées, des biguanides, des glitazones, des inhibiteurs d'alpha-glucosidase, des antagonistes du canal potassique, des inhibiteurs d'aldose réductase, des antagonistes de glucagon, des activateurs de RXR, un agent d'insulinothérapie ou un autre agent anti-obésité. Ces méthodes comprennent l'administration du composé de formule (I) combiné avec un agent antidiabétique, ces deux composés étant administrés de manière simultanée, le composé de formule (I) pouvant être administré en premier avant l'agent antidiabétique, lequel peut également être administré en premier avant ledit composé de formule (I).
PCT/US2001/014393 2000-05-03 2001-05-02 Compositions therapeutiques combinees et leurs methodes d'utilisation Ceased WO2001082916A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU6118001A AU6118001A (en) 2000-05-03 2001-05-02 Combination therapeutic compositions and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20161300P 2000-05-03 2000-05-03
US60/201,613 2000-05-03

Publications (2)

Publication Number Publication Date
WO2001082916A2 WO2001082916A2 (fr) 2001-11-08
WO2001082916A3 true WO2001082916A3 (fr) 2002-07-04

Family

ID=22746541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014393 Ceased WO2001082916A2 (fr) 2000-05-03 2001-05-02 Compositions therapeutiques combinees et leurs methodes d'utilisation

Country Status (3)

Country Link
US (3) US6653332B2 (fr)
AU (1) AU6118001A (fr)
WO (1) WO2001082916A2 (fr)

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US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
US7626033B2 (en) 1999-06-30 2009-12-01 Amgen Inc. Compounds for the modulation of PPARγ activity

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US6653332B2 (en) 2003-11-25
US7939551B2 (en) 2011-05-10
US20020037928A1 (en) 2002-03-28
AU6118001A (en) 2001-11-12
US20040259918A1 (en) 2004-12-23

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