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WO2001079426A3 - Nouveau polypeptide, proteine humaine atm 20 de l'ataxie cinetique-telangiectasie, et polynucleotide codant pour ce polypeptide - Google Patents

Nouveau polypeptide, proteine humaine atm 20 de l'ataxie cinetique-telangiectasie, et polynucleotide codant pour ce polypeptide Download PDF

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Publication number
WO2001079426A3
WO2001079426A3 PCT/CN2001/000370 CN0100370W WO0179426A3 WO 2001079426 A3 WO2001079426 A3 WO 2001079426A3 CN 0100370 W CN0100370 W CN 0100370W WO 0179426 A3 WO0179426 A3 WO 0179426A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide encoding
present
atm protein
polypeptide
telangiectasis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2001/000370
Other languages
English (en)
Chinese (zh)
Other versions
WO2001079426A2 (fr
Inventor
Yumin Mao
Yi Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Biowindow Gene Development Inc
Original Assignee
Shanghai Biowindow Gene Development Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Biowindow Gene Development Inc filed Critical Shanghai Biowindow Gene Development Inc
Priority to AU56052/01A priority Critical patent/AU5605201A/en
Publication of WO2001079426A2 publication Critical patent/WO2001079426A2/fr
Publication of WO2001079426A3 publication Critical patent/WO2001079426A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un nouveau polypeptide, une protéine humaine ATM 20 de l'ataxie cinétique-télangiectasie, et un polynucléotide codant pour ce polypeptide ainsi qu'un procédé d'obtention de ce polypeptide par des techniques recombinantes d'ADN. L'invention concerne en outre les applications de ce polypeptide dans le traitement de maladies, notamment de l'ataxie-télangiectasie, du cancer du sein, des leucémies, des lymphomes, d'autres tumeurs, des maladies immunitaires, des troubles du développement, des inflammations, de l'hémopathie et de l'infection par VIH. L'invention concerne aussi l'antagoniste agissant contre le polypeptide et son action thérapeutique ainsi que les applications de ce polynucléotide codant pour la protéine humaine ATM 20 de l'ataxie cinétique-télangiectasie.
PCT/CN2001/000370 2000-03-22 2001-03-19 Nouveau polypeptide, proteine humaine atm 20 de l'ataxie cinetique-telangiectasie, et polynucleotide codant pour ce polypeptide Ceased WO2001079426A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56052/01A AU5605201A (en) 2000-03-22 2001-03-19 A novel polypeptide, a human kinetic ataxia telangiectasia protein atm20 and thepolynucleotide encoding the polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN00115022.7 2000-03-22
CN00115022A CN1314381A (zh) 2000-03-22 2000-03-22 一种新的多肽——人运动性共济失调－毛细管扩张atm蛋白20和编码这种多肽的多核苷税

Publications (2)

Publication Number Publication Date
WO2001079426A2 WO2001079426A2 (fr) 2001-10-25
WO2001079426A3 true WO2001079426A3 (fr) 2002-02-07

Family

ID=4584493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2001/000370 Ceased WO2001079426A2 (fr) 2000-03-22 2001-03-19 Nouveau polypeptide, proteine humaine atm 20 de l'ataxie cinetique-telangiectasie, et polynucleotide codant pour ce polypeptide

Country Status (3)

Country Link
CN (1) CN1314381A (fr)
AU (1) AU5605201A (fr)
WO (1) WO2001079426A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104178487B (zh) * 2013-05-20 2017-09-19 中南大学湘雅医院 Atm基因突变体及其应用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLACK G.C. ET AL.: "Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis", HUM. MOL. GENET., vol. 8, no. 11, 1999, pages 2031 - 2035 *
CLAVERIE J.M. AND MAKALOWSKI W.: "Alu alert", NATURE, vol. 371, no. 6500, 1994, pages 752 *
DATABASE GENBANK [online] 19 October 1999 (1999-10-19), "Homo sapiens chromosome 14 BAC 98L12", Database accession no. AC008015 *
FUCHS S. ET AL.: "A missense point mutation (Leu13Arg) of the Norrie disease gene in a large Cuban kindred with Norrie disease", HUM. MOL. GENET., vol. 3, no. 4, 1994, pages 655 - 656 *
MATSUMURA M. ET AL.: "Stabilization of phage T4 lysozyme by engineered disulfide bonds", PROC. NATL. ACAD. SCI. USA, vol. 86, no. 17, 1989, pages 6562 - 6566 *

Also Published As

Publication number Publication date
AU5605201A (en) 2001-10-30
CN1314381A (zh) 2001-09-26
WO2001079426A2 (fr) 2001-10-25

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