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WO2001076743A3 - Appareil et procede destines a l'analyse d'un analyte fluidique - Google Patents

Appareil et procede destines a l'analyse d'un analyte fluidique Download PDF

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Publication number
WO2001076743A3
WO2001076743A3 PCT/GB2001/001650 GB0101650W WO0176743A3 WO 2001076743 A3 WO2001076743 A3 WO 2001076743A3 GB 0101650 W GB0101650 W GB 0101650W WO 0176743 A3 WO0176743 A3 WO 0176743A3
Authority
WO
WIPO (PCT)
Prior art keywords
flow rate
chamber
fluid sample
detection based
analyte detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/001650
Other languages
English (en)
Other versions
WO2001076743A2 (fr
Inventor
Elizabeth Anne Howlett Hall
Ian Stuart Harding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge University Technical Services Ltd CUTS
Original Assignee
Cambridge University Technical Services Ltd CUTS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge University Technical Services Ltd CUTS filed Critical Cambridge University Technical Services Ltd CUTS
Priority to AU2001248542A priority Critical patent/AU2001248542A1/en
Publication of WO2001076743A2 publication Critical patent/WO2001076743A2/fr
Anticipated expiration legal-status Critical
Publication of WO2001076743A3 publication Critical patent/WO2001076743A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
    • G01F1/708—Measuring the time taken to traverse a fixed distance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un capteur destiné à quantifier le débit ou la viscosité d'un échantillon fluidique, ou la concentration d'un analyte dans cet échantillon fluidique. Ce capteur comprend une chambre destinée à loger un échantillon fluidique et à le guider à travers un canal contenant un dispositif de détection. Cette chambre comprend au moins une et de préférence deux variations de diamètre entraînant des changements détectables dans l'écoulement de l'échantillon dans la chambre et dans les mesures du dispositif de détection. Les dimensions de la chambre étant connues, on peut calculer le débit et la viscosité de l'échantillon fluidique. Ces résultats peuvent alors être utilisés pour calculer la concentration d'un analyte, directement ou indirectement, en dépit de toute dépendance de débit du dispositif de détection.
PCT/GB2001/001650 2000-04-12 2001-04-12 Appareil et procede destines a l'analyse d'un analyte fluidique Ceased WO2001076743A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001248542A AU2001248542A1 (en) 2000-04-12 2001-04-12 Fluid analyte detection based on flow rate or viscosity measurement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0008950.8 2000-04-12
GB0008950A GB0008950D0 (en) 2000-04-12 2000-04-12 Apparatus and method for assay of a fluid analyte

Publications (2)

Publication Number Publication Date
WO2001076743A2 WO2001076743A2 (fr) 2001-10-18
WO2001076743A3 true WO2001076743A3 (fr) 2004-02-26

Family

ID=9889722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001650 Ceased WO2001076743A2 (fr) 2000-04-12 2001-04-12 Appareil et procede destines a l'analyse d'un analyte fluidique

Country Status (3)

Country Link
AU (1) AU2001248542A1 (fr)
GB (1) GB0008950D0 (fr)
WO (1) WO2001076743A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5311801B2 (ja) * 2007-11-09 2013-10-09 キヤノン株式会社 浸透圧ポンプを用いた送液駆動機構および該送液駆動機構を有するマイクロチップ
CN103439260B (zh) * 2013-09-17 2015-07-29 国核电站运行服务技术有限公司 分光光度计固体样品支架
CN107389911A (zh) * 2017-07-12 2017-11-24 柳州康云互联科技有限公司 用于移动端的快速分离检测传感器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3138514A1 (de) * 1981-09-28 1983-04-14 Klaus Dipl.-Ing. 5100 Aachen Mussler Verfahren und vorrichtung zur bestimmung des fliessverhaltens biologischer fluessigkeiten
US4793174A (en) * 1987-10-05 1988-12-27 E. I. Du Pont De Nemours And Company Differential pressure capillary viscometer
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
WO1999009388A2 (fr) * 1997-08-18 1999-02-25 Metasensors, Inc. Procede et appareil pour l'analyse de gaz en temps reel
WO2001024297A1 (fr) * 1999-09-24 2001-04-05 Siemens Aktiengesellschaft Determination de la concentration d'alcool dans l'electrolyte de piles a combustible

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3138514A1 (de) * 1981-09-28 1983-04-14 Klaus Dipl.-Ing. 5100 Aachen Mussler Verfahren und vorrichtung zur bestimmung des fliessverhaltens biologischer fluessigkeiten
US4793174A (en) * 1987-10-05 1988-12-27 E. I. Du Pont De Nemours And Company Differential pressure capillary viscometer
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
WO1999009388A2 (fr) * 1997-08-18 1999-02-25 Metasensors, Inc. Procede et appareil pour l'analyse de gaz en temps reel
WO2001024297A1 (fr) * 1999-09-24 2001-04-05 Siemens Aktiengesellschaft Determination de la concentration d'alcool dans l'electrolyte de piles a combustible
DE19945931A1 (de) * 1999-09-24 2001-05-03 Siemens Ag Bestimmung der Alkoholkonzentration im Elektrolyt von Brennstoffzellen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GOODING J J ET AL: "A FILL-AND-FLOW BIOSENSOR", ANALYTICAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. COLUMBUS, vol. 70, no. 15, 1 August 1998 (1998-08-01), pages 3131 - 3136, XP000776674, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
AU2001248542A1 (en) 2001-10-23
WO2001076743A2 (fr) 2001-10-18
GB0008950D0 (en) 2000-05-31

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