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WO2001074809A1 - Derives d'acylthiophene et leur utilisation en tant que medicaments - Google Patents

Derives d'acylthiophene et leur utilisation en tant que medicaments Download PDF

Info

Publication number
WO2001074809A1
WO2001074809A1 PCT/JP2001/002705 JP0102705W WO0174809A1 WO 2001074809 A1 WO2001074809 A1 WO 2001074809A1 JP 0102705 W JP0102705 W JP 0102705W WO 0174809 A1 WO0174809 A1 WO 0174809A1
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
acylthiophene
blood cells
drugs
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2001/002705
Other languages
English (en)
Japanese (ja)
Inventor
Yuji Sugawara
Hideki Kawai
Kiyoshi Okano
Yasumoto Adachi
Katsuyuki Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of WO2001074809A1 publication Critical patent/WO2001074809A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des dérivés d'acylthiophène comprenant, généralement, le composé de formule (I), ou des sels de ceux-ci, acceptables au plan pharmaceutique. L'invention porte également sur des médicaments contenant lesdits dérivés ou sels en tant que principe actif. Lesdits dérivés induisent la production de plaquettes, de leucocytes, d'érythrocytes ou similaire, et sont utiles dans la chimiothérapie du cancer, la radiothérapie, la thérapie par greffe de moelle osseuse ou la pharmacothérapie ainsi que dans la prévention ou le traitement de la cytopénie consécutive à des troubles immunitaires, à l'anémie ou similaire.
PCT/JP2001/002705 2000-03-30 2001-03-30 Derives d'acylthiophene et leur utilisation en tant que medicaments Ceased WO2001074809A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000093610 2000-03-30
JP2000-093610 2000-03-30

Publications (1)

Publication Number Publication Date
WO2001074809A1 true WO2001074809A1 (fr) 2001-10-11

Family

ID=18608772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/002705 Ceased WO2001074809A1 (fr) 2000-03-30 2001-03-30 Derives d'acylthiophene et leur utilisation en tant que medicaments

Country Status (1)

Country Link
WO (1) WO2001074809A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100348591C (zh) * 2004-07-15 2007-11-14 浙江海正集团有限公司 取代亚甲基吡喃酮类衍生物及其制备方法和用途
WO2011088152A1 (fr) 2010-01-12 2011-07-21 Portola Pharmaceuticals, Inc. Composition pharmaceutique et forme galénique de l'élinogrel et leurs méthodes d'application
CN1990478B (zh) * 2005-12-26 2011-08-31 浙江海正药业股份有限公司 6-芳基-3-取代亚甲基吡喃酮类化合物及其制备方法和用途
CN119798241A (zh) * 2025-03-17 2025-04-11 北京元延医药科技股份有限公司 简便制备高纯度洛替拉纳的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0841063A1 (fr) * 1996-03-27 1998-05-13 Toray Industries, Inc. Derives de cetone et usage medicinal
EP0962456A1 (fr) * 1997-09-26 1999-12-08 Toray Industries, Inc. Derive de cetone et son utilisation en medecine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0841063A1 (fr) * 1996-03-27 1998-05-13 Toray Industries, Inc. Derives de cetone et usage medicinal
EP0962456A1 (fr) * 1997-09-26 1999-12-08 Toray Industries, Inc. Derive de cetone et son utilisation en medecine

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100348591C (zh) * 2004-07-15 2007-11-14 浙江海正集团有限公司 取代亚甲基吡喃酮类衍生物及其制备方法和用途
CN1990478B (zh) * 2005-12-26 2011-08-31 浙江海正药业股份有限公司 6-芳基-3-取代亚甲基吡喃酮类化合物及其制备方法和用途
WO2011088152A1 (fr) 2010-01-12 2011-07-21 Portola Pharmaceuticals, Inc. Composition pharmaceutique et forme galénique de l'élinogrel et leurs méthodes d'application
CN119798241A (zh) * 2025-03-17 2025-04-11 北京元延医药科技股份有限公司 简便制备高纯度洛替拉纳的方法

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