[go: up one dir, main page]

WO2001073077A3 - Regulation de serine racemase humaine - Google Patents

Regulation de serine racemase humaine Download PDF

Info

Publication number
WO2001073077A3
WO2001073077A3 PCT/EP2001/003668 EP0103668W WO0173077A3 WO 2001073077 A3 WO2001073077 A3 WO 2001073077A3 EP 0103668 W EP0103668 W EP 0103668W WO 0173077 A3 WO0173077 A3 WO 0173077A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulation
decrease
racemase enzyme
serine
human serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/003668
Other languages
English (en)
Other versions
WO2001073077A2 (fr
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001250408A priority Critical patent/AU2001250408A1/en
Priority to EP01923705A priority patent/EP1272646A2/fr
Publication of WO2001073077A2 publication Critical patent/WO2001073077A2/fr
Anticipated expiration legal-status Critical
Publication of WO2001073077A3 publication Critical patent/WO2001073077A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/01—Racemaces and epimerases (5.1) acting on amino acids and derivatives (5.1.1)
    • C12Y501/01018—Serine racemase (5.1.1.18)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne la régulation de sérine racémase humaine, afin de favoriser ou d'inhiber la formation de D-sérine, ce qui résulte en une augmentation ou une diminution de l'activation des récepteurs NMDA. L'inhibition de formation de D-sérine peut aider à prévenir des dommages neuronaux résultant d'un événement ischémique, tel qu'un accident vasculaire cérébral. La régulation de formation de D-sérine peut également aider à traiter d'autres états neurodégénératifs induits par la sur-activation ou la sous-activation du récepteur NMDA de glutamate.
PCT/EP2001/003668 2000-03-31 2001-03-30 Regulation de serine racemase humaine Ceased WO2001073077A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001250408A AU2001250408A1 (en) 2000-03-31 2001-03-30 Regulation of human serine racemase enzyme
EP01923705A EP1272646A2 (fr) 2000-03-31 2001-03-30 Regulation de serine racemase humaine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19374800P 2000-03-31 2000-03-31
US60/193,748 2000-03-31
US19424900P 2000-04-03 2000-04-03
US60/194,249 2000-04-03

Publications (2)

Publication Number Publication Date
WO2001073077A2 WO2001073077A2 (fr) 2001-10-04
WO2001073077A3 true WO2001073077A3 (fr) 2002-10-03

Family

ID=26889313

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003668 Ceased WO2001073077A2 (fr) 2000-03-31 2001-03-30 Regulation de serine racemase humaine

Country Status (3)

Country Link
EP (1) EP1272646A2 (fr)
AU (1) AU2001250408A1 (fr)
WO (1) WO2001073077A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109251923B (zh) * 2018-10-22 2021-06-15 天津博瑞威生物医药科技有限公司 丝氨酸消旋酶突变体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043526A1 (fr) * 1999-01-19 2000-07-27 The Johns Hopkins University Serine racemase de mammifere
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
CN1300824A (zh) * 1999-12-21 2001-06-27 复旦大学 一种新的多肽－丝氨酸/苏氨酸脱水酶37和编码这种多肽的多核苷酸
WO2001060987A1 (fr) * 2000-02-17 2001-08-23 Millennium Pharmaceuticals, Inc. Membre de la famille des enzymes humaines dependant du pyridoxal phosphate et utilisation relative
WO2001075144A1 (fr) * 2000-04-04 2001-10-11 Merck & Co., Inc. Serine racemase humaine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043526A1 (fr) * 1999-01-19 2000-07-27 The Johns Hopkins University Serine racemase de mammifere
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
CN1300824A (zh) * 1999-12-21 2001-06-27 复旦大学 一种新的多肽－丝氨酸/苏氨酸脱水酶37和编码这种多肽的多核苷酸
WO2001060987A1 (fr) * 2000-02-17 2001-08-23 Millennium Pharmaceuticals, Inc. Membre de la famille des enzymes humaines dependant du pyridoxal phosphate et utilisation relative
WO2001075144A1 (fr) * 2000-04-04 2001-10-11 Merck & Co., Inc. Serine racemase humaine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 27 May 1997 (1997-05-27), HILLIER L. ET AL.: "zw89f02.s1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE:784155 3' similar to SW:YKV8_YEAST P36007 HYPOTHETICAL 34.9 KD PROTEIN IN FRE2-JEN1 INTERGENIC REGION. ;, mRNA sequence.", XP002204937, Database accession no. AA432108 *
DATABASE EMBL [online] 5 June 1997 (1997-06-05), HILLIER, L. ET AL.: "zw89f02.r1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE:784155 5' similar to SW:YKV8_YEAST P36007 HYPOTHETICAL 34.9 KD PROTEIN IN FRE2-JEN1 INTERGENIC REGION. ;, mRNA sequence.", XP002204938, Database accession no. AA446793 *
DATABASE GENESEQ 27 November 2001 (2001-11-27), "Serine/threonine dehydrase 37; cancer; HIV infection; anti-HIV; cytostatic; ss.", XP002204939 *
DATABASE WPI Section Ch Week 200159, Derwent World Patents Index; Class B04, AN 2001-530468, XP002204940 *
DE MIRANDA J ET AL: "Human serine racemase: molecular cloning, genomic organization and functional analysis", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 256, no. 1-2, 3 October 2000 (2000-10-03), pages 183 - 188, XP004238403, ISSN: 0378-1119 *
HERMAN WOLOSKER ET AL: "Serine racemase: a glial enzyme synthesizing D-Serine to regulate glutamate-N-methyl-D-aspartate neurotransmission", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 23, 9 November 1999 (1999-11-09), pages 13409 - 13414, XP002135967, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1272646A2 (fr) 2003-01-08
WO2001073077A2 (fr) 2001-10-04
AU2001250408A1 (en) 2001-10-08

Similar Documents

Publication Publication Date Title
WO2001075315A3 (fr) Systeme de vis a ajustement automatique
WO2003063794A3 (fr) Composes 2,4-pyrimidinediamine et leurs utilisations
WO2003070735A3 (fr) Elements permettant la preparation de liposomes amphoteres
WO2001079460A3 (fr) Polypeptides a activite haloperoxydase
WO2001060778A3 (fr) Mediateurs lipidiques actives par l'aspirine
NZ503963A (en) 1-substituted-1-aminomethyl-cycloalkane derivatives, or gabapentin analogues, preparation and use in the treatment of neurological disorders
EP1149911A3 (fr) Souches d'Escherichia produisant des acides aminés et procédé de production d'acide aminé
AU2003289264A1 (en) Mutant d-aminotransferase and process for producing optically active glutamic acid derivative using the same
AU2003299791A1 (en) Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
ZA200407817B (en) 2-(2,6-Dichlorophenyl)-diarylimidazoles.
WO2004009034A3 (fr) Analogues de thiomolybdate et leurs utilisations
EP1645761A3 (fr) Elément de palier
MY129372A (en) Process to prepare oxazolidinones
WO2004043918A3 (fr) Nouvelles formes cristallines d'atorvastatine hemi-calcium et leurs procedes de preparation ainsi que de nouveaux procedes de preparation d'autres formes
DK1341749T3 (da) Fremgangsmåde til fremstilling af gabapentin
AU2003298913A1 (en) Treatment of inflammatory disorders with 2,3-benzodiazepines
WO2006006108A3 (fr) Procede et systeme de communication entre utilisateur et systeme
WO2003063576A3 (fr) Composes arylsulfonamidobenzyliques
WO2003079962A3 (fr) Unite de liaison de systemes therapeutiques transdermiques separables individuellement
WO2001073077A3 (fr) Regulation de serine racemase humaine
CA2286296A1 (fr) Inhibiteurs pour le recepteur de l'urokinase
ITMI20021884A1 (it) Buratto piano per la separazione dei prodotti derivanti dalla macinazione di cereali.
WO2002070499A3 (fr) Derives de promedicaments a base d'acide ascorbique pouvant traverser la barriere hematoencephalique
AU2002257597A1 (en) Immunomodulating agents from parasitic worms and method for isolation thereof
AU2001294494A1 (en) Structure that counteracts bio-fouling in aquatic environments

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001923705

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWP Wipo information: published in national office

Ref document number: 2001923705

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10240466

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP

WWR Wipo information: refused in national office

Ref document number: 2001923705

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001923705

Country of ref document: EP