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WO2001070997A3 - Regulation of human leucine aminopeptidase-like enzyme - Google Patents

Regulation of human leucine aminopeptidase-like enzyme Download PDF

Info

Publication number
WO2001070997A3
WO2001070997A3 PCT/EP2001/003331 EP0103331W WO0170997A3 WO 2001070997 A3 WO2001070997 A3 WO 2001070997A3 EP 0103331 W EP0103331 W EP 0103331W WO 0170997 A3 WO0170997 A3 WO 0170997A3
Authority
WO
WIPO (PCT)
Prior art keywords
leucine aminopeptidase
regulation
enzyme
human leucine
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/003331
Other languages
French (fr)
Other versions
WO2001070997A2 (en
Inventor
Shyam Ramakrishnan
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to EP01915412A priority Critical patent/EP1268814A2/en
Priority to AU2001242512A priority patent/AU2001242512A1/en
Publication of WO2001070997A2 publication Critical patent/WO2001070997A2/en
Publication of WO2001070997A3 publication Critical patent/WO2001070997A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human leucine aminopeptidase-like enzyme activity and reagents which bind to human leucine aminopeptidase-like enzyme gene products can be used to regulate cellular and extracellular polypeptide degradation. Such regulation is particularly useful for treating cancer, HIV, autoimmune disease, and high blood pressure.
PCT/EP2001/003331 2000-03-24 2001-03-23 Regulation of human leucine aminopeptidase-like enzyme Ceased WO2001070997A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01915412A EP1268814A2 (en) 2000-03-24 2001-03-23 Regulation of human leucine aminopeptidase-like enzyme
AU2001242512A AU2001242512A1 (en) 2000-03-24 2001-03-23 Regulation of human leucine aminopeptidase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19171600P 2000-03-24 2000-03-24
US60/191,716 2000-03-24

Publications (2)

Publication Number Publication Date
WO2001070997A2 WO2001070997A2 (en) 2001-09-27
WO2001070997A3 true WO2001070997A3 (en) 2002-02-28

Family

ID=22706648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003331 Ceased WO2001070997A2 (en) 2000-03-24 2001-03-23 Regulation of human leucine aminopeptidase-like enzyme

Country Status (3)

Country Link
EP (1) EP1268814A2 (en)
AU (1) AU2001242512A1 (en)
WO (1) WO2001070997A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535241A1 (en) * 1991-04-08 1993-04-07 Suntory Limited Novel leucine aminopeptidase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535241A1 (en) * 1991-04-08 1993-04-07 Suntory Limited Novel leucine aminopeptidase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL SEQUENCE LIBRARY 12 April 1997 (1997-04-12), NCI-CGAP: ""National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index http://www.ncbi.nlm.nih.gov/ncicgap";", XP002182943 *
DATABASE EMBL SEQUENCE LIBRARY 13 June 1997 (1997-06-13), HILLIER, L., ET AL.: "WashU-Merck EST project 1997", XP002182942 *
DATABASE EMBL SEQUENCE LIBRARY 14 March 1995 (1995-03-14), NONE: ""Genome sequence of the nematode C. elegans: a platform for investigating biology. The C. elegans Sequencing Consortium" - Caenorhabditis elegans cosmid B0495, complete sequence", XP002182941 *
DATABASE SWALL-DATABASE 1 November 1997 (1997-11-01), KIRSTEN, J.: "HYPOTHETICAL 98.3 KDA PROTEIN B0495.7 IN CHROMOSOME II. - Caenorhabditis elegans.", XP002182940 *
HATTORI AKIRA ET AL: "Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 125, no. 5, May 1999 (1999-05-01), pages 931 - 938, XP002155174, ISSN: 0021-924X *

Also Published As

Publication number Publication date
EP1268814A2 (en) 2003-01-02
AU2001242512A1 (en) 2001-10-03
WO2001070997A2 (en) 2001-09-27

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