WO2001070980A9 - Isolated g-protein coupled receptors, nucleic acid molecules encoding gpcr proteins, and uses thereof as insecticidal targets - Google Patents

Abstract

The present invention provides amino acid sequences of proteins that are encoded by genes within the Drosophila melanogaster genome, the GPCR proteins of the present invention. The present invention specifically provides isolated protein and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR proteins and methods of identifying modulators of the GPCR proteins for use as insecticides.

Description

ISOLATED G-PROTEIN COUPLED RECEPTORS, NUCLEIC ACID MOLECULES ENCODING GPCR PROTEINS, AND USES THEREOF AS 1NSECTICIDAL TARGETS

RELATED APPLICATIONS The present application claims priority to U.S. Serial No. 60/191,638, filed March 23,

2000 (Atty. Docket CL000388) and U.S. Serial No. 09/618,893, filed July 18, 2000 (Atty. Docket CL000733).

FIELD OF THE INVENTION The present invention is in the field of G-Protein coupled receptors (GPCRs), recombinant DNA molecules and protein production. The present invention specifically provides novel GPCR proteins and nucleic acid molecules encoding such protein molecules, for use in the development of insecticide and insecticide targets and as a source for identifying human therapeutics and human therapeutic development.

BACKGROUND OF THE INVENTION

The Drosophila melanogaster genome is 165 Mb, with about 120 Mb of this being euchromatic. The genome is organized in 4 chromosome pairs and is estimated to contain 10 - 12,000 genes. Model organisms, such as Drosophila melanogaster, share many genes with humans whose sequences and functions have been conserved. In addition to myriad similarities in cellular structure and function, humans and Drosophila share pathways for intercellular signaling, developmental patterning, learning and behavior, as well as tumor formation and metastasis.

The genes involved in the development of Drosophila, with few exceptions, are the same as those involved in the development of higher organisms. Developmental biology studies the sequential activation and interaction of genes, in relation to developing morphology. Right now, Drosophila is the only organism for which one can begin with a list of genes active in the egg and follow the morphological changes and gene activations through to adulthood.

Drosophila studies have provided the widest knowledge base available for any single organism; accordingly, developmental biologists use the fly to ferret out the activity of genes with similar functions in higher organisms. Despite its small size, the fly is by no means a small developmental problem. If you know the genes involved in the development of the fly, you also know, to a reasonable approximation, the genes involved in the development of the worm, the fish, the mouse, and humans.

A major goal in drug/insecticide development is to understand and elucidate the molecular mechanisms that govern cell signaling and cell-cell interactions in higher eukaryotes. GPCRs form major links in cellular communication/response systems. A complete list of GPCR proteins from Drosophila would therefore be invaluable in developing human therapeutic targets. Not only will the proteins serve as models for human cellular signaling and response, such molecules will also serve as molecular keys in identifying therapeutically important human orthologs.

G-protein coupled receptors

G-protein coupled receptors (GPCRs) constitute a major class of proteins responsible for transducing a signal within a cell. GPCRs have three structural domains: an amino terminal extracellular domain, a transmembrane domain containing seven transmembrane segments, three extracellular loops, and three intracellular loops, and a carboxy terminal intracellular domain. Upon binding of a ligand to an extracellular portion of a GPCR, a signal is transduced within the cell that results in a change in a biological or physiological property of the cell. GPCRs, along with G- proteins and effectors (intracellular enzymes and channels modulated by G-proteins), are the components of a modular signaling system that connects the state of intracellular second messengers to extracellular inputs.

GPCR genes and gene-products are potential causative agents of disease (Spiegel et al, J. Clin. Invest. 92:1119-1125 (1993); McKusick et al., J. Med. Genet. 30: -26 (1993)). Specific defects in the rhodopsin gene and the V2 vasopressin receptor gene have been shown to cause various forms of retinitis pigmentosum (Nathans et al, Annu. Rev. Genet. 2(5:403-424(1992)), and nephrogenic diabetes insipidus (Holtzman et al, Hum. Mol. Genet. 2:1201-1204 (1993)). These receptors are of critical importance to both the central nervous system and peripheral physiological processes. Evolutionary analyses suggest that the ancestor of these proteins originally developed in concert with complex body plans and nervous systems.

The GPCR protein superfamily can be divided into five families: Family I, receptors typified by rhodopsin and the β2-adrenergic receptor and currently represented by over 200 unique members (Dohlman et al, Annu. Rev. Biochem. 60:653-688 (1991)); Family II, the parathyroid hormone/calcitonin secretin receptor family (Juppner et al, Science 254:1024-1026 (1991); Lin et al, Science 254:1022-1024 (1991)); Family III, the metabotropic glutamate receptor family (Nakanishi, Science 258 597:603 (1992)); Family IV, the cAMP receptor family, important in the chemotaxis and development of D discoideum (Klein et al, Science 241 A67-IA12 (1988)); and Family V, the fungal mating pheromone receptors such as STE2 (Kurjan, Annu. Rev. Biochem. 67:1097-1129 (1992)). There are also a small number of other proteins, which present seven putative hydrophobic segments and appear to be unrelated to GPCRs; they have not been shown to couple to G-proteins. Drosophila expresses a photoreceptor-specific protein, bride of sevenless (boss), a seven- transmembrane-segment protein, which has been extensively studied and does not show evidence of being a GPCR (Hart et al, Proc. Natl. Acad. Sci. USA 90:5047-5051 (1993)). The gene frizzled (fz) in Drosophila is also thought to be a protein with seven transmembrane segments. Like boss, fz has not been shown to couple to G-proteins (Vinson et al, Nature 338:263-26A (1989)).

G proteins represent a family of heterotrimeric proteins composed of α, β and γ subunits, that bind guanine nucleotides. These proteins are usually linked to cell surface receptors, e.g., receptors containing seven transmembrane segments. Following ligand binding to the GPCR, a conformational change is transmitted to the G protein, which causes the α-subunit to exchange a bound GDP molecule for a GTP molecule and to dissociate from the βγ-subunits. The GTP-bound form of the α-subunit typically functions as an effector-modulating moiety, leading to the production of second messengers, such as cAMP (e.g., by activation of adenyl cyclase), diacylglycerol or inositol phosphates. Greater than 20 different types of α-subunits are known in humans. These subunits associate with a smaller pool of β and γ subunits. Examples of mammalian G proteins include Gi, Go, Gq, Gs and Gt. G proteins are described extensively in Lodish et al, Molecular Cell Biology, (Scientific American Books Inc., New York, N.Y., 1995), the contents of which are incoφorated herein by reference. GPCRs, G proteins and G protein-linked effector and second messenger systems have been reviewed in The G-Protein Linked Receptor Fact Book, Watson et al, eds., Academic Press (1994).

Dopamine receptors

The understanding of the dopaminergic system relevance in brain function and disease developed several decades ago from three diverse observations following drug treatments. These were the observations that dopamine replacement therapy improved Parkinson's disease symptoms, depletion of dopamine and other catecholamines by reserpine caused depression and antipsychotic drugs blocked dopamine receptors. The finding that the dopamine receptor binding affinities of typical antipsychotic drugs correlate with their clinical potency led to the dopamine overactivity hypothesis of schizophrenia (Snyder, S.H., Am J Psychiatry 133, 197-202 (1976); Seeman, P. and Lee, T., Science 188, 1217-9 (1975)). Today, dopamine receptors are crucial targets in the pharmacological therapy of schizophrenia, Parkinson's disease, Tourette's syndrome, tardive dyskinesia and Huntington's disease. The dopaminergic system includes the nigrostriatal, mesocorticolimbic and tuberoinfundibular pathways. The nigrostriatal pathway is part of the striatal motor system and its degeneration leads to Parkinson's disease; the mesocorticolimbic pathway plays a key role in reinforcement and in emotional expression and is the desired site of action of antipsychotic drugs; the tuberoinfundibular pathways regulates prolactin secretion from the pituitary. Dopamine receptors are members of the G protein coupled receptor superfamily, a large group proteins that share a seven helical membrane-spanning structure and transduce signals through coupling to heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins). Dopamine receptors are classified into subfamilies: Dl-like (Dl and D5) and D2-like (D2, D3 and D4) based on their different ligand binding profiles, signal transduction properties, sequence homologies and genomic organizations (Civelli, O., Bunzow, J.R. and Grandy, D.K., Annu Rev Pharmacol Toxicol 33, 281-307 (1993)). The Dl-like receptors, Dl and D5, stimulate cAMP synthesis through coupling with Gs-like proteins and their genes do not contain introns within their protein coding regions. On the other hand, the D2-like receptors, D2, D3 and D4, inhibit cAMP synthesis through their interaction with Gi-like proteins and share a similar genomic organization which includes introns within their protein coding regions.

Serotonin receptors

Serotonin (5-Hydroxytryptamine; 5-HT) was first isolated from blood serum, where it was shown to promote vasoconstriction (Rapport, M.M., Green, A.A. and Page, I.H., JBiol Chem 176, 1243-1251 ( 1948). Interest on a possible relationship between 5-HT and psychiatric disease was spurred by the observations that hallucinogens such as LSD and psilocybin inhibit the actions of 5- HT on smooth muscle preparations (Gaddum, J.H. and Hameed, K.A., BrJ Pharmacol 9, 240-248 (1954)). This observation lead to the hypothesis that brain 5-HT activity might be altered in psychiatric disorders (Wooley, D.W. and Shaw, E., Proc Natl Acad Sci USA 40, 228-231 (1954); Gaddum, J.H. and Picarelli, Z.P., BrJ Pharmacol 12, 323-328 (1957)). This hypothesis was strengthened by the introduction of tricyclic antidepressants and monoamine oxidase inhibitors for the treatment of major depression and the observation that those drugs affected noradrenaline and 5- HT metabolism. Today, drugs acting on the serotoninergic system have been proved to be effective in the pharmaco herapy of psychiatric diseases such as depression, schizophrenia, obsessive- compulsive disorder, panic disorder, generalized anxiety disorder and social phobia as well as migraine, vomiting induced by cancer chemotherapy and gastric motility disorders.

Serotonin receptors represent a very large and diverse family of neurotransmitter receptors. To date thirteen 5-HT receptor proteins coupled to G proteins plus one ligand-gated ion channel receptor (5-HT3) have been described in mammals. This receptor diversity is thought to reflect serotonin's ancient origin as a neurotransmitter and a hormone as well as the many different roles of 5-HT in mammals. The 5-HT receptors have been classified into seven subfamilies or groups according to their different ligand-binding affinity profiles, molecular structure and intracellular transduction mechanisms (Hoyer, D. et al., Pharmacol Rev. 46, 157-203 (1994)).

GPCRs are a major target for drug/insecticide action and development. Accordingly, it is valuable to the field of pharmaceutical development to identify and characterize previously unknown GPCRs. The present invention advances the state of the art by providing a previously unidentified drosophila GPCRs.

Insecticides

About 10,000 species of the more than 1 million species of insects are crop-eating, and of these, approximately 700 species worldwide cause most of the insect damage to man's crops, in the field and in storage. A detailed study of novel proteins from Drosophila and invertebrate orthologs thereof, will serve as targets for identifying new members of the known classes of insecticides as well as aiding in the identification of new classes of compounds.

SUMMARY OF THE INVENTION The present invention is based in part on the identification of nucleic acid sequences that encode amino acid sequences of 66 GPCR proteins that are produced by Drosophila melanogaster and invertebrate, human and other mammalian orthologs thereof These unique protein sequences, and nucleic acid sequences that encode these proteins, can be used as models for the development of human therapeutic targets, aid in the identification of therapeutic proteins and serve as targets for the development of human therapeutic and insecticidal agents.

The proteins of the present inventions are GPCRs that participate in signaling pathways. As used herein, a "signaling pathway" refers to the modulation (e.g., stimulation or inhibition) of a cellular function/activity upon the binding of a ligand to the GPCR protein. Examples of such functions include mobilization of intracellular molecules that participate in a signal transduction pathway, e.g., phosphatidylinositol 4,5-bisphosphate (PIP₂), inositol 1 ,4,5-triphosphate (IP₃) and adenylate cyclase; polarization of the plasma membrane; production or secretion of molecules; alteration in the structure of a cellular component; cell proliferation, e.g., synthesis of DNA; cell migration; cell differentiation; and cell survival

The response mediated by the receptor protein depends on the type of cell. For example, in some cells, binding of a ligand to the receptor protein may stimulate an activity such as release of compounds, gating of a channel, cellular adhesion, migration, differentiation, etc., through phosphatidylinositol or cyclic AMP metabolism and turnover while in other cells, the binding of the ligand will produce a different result. Regardless of the cellular activity/response modulated by the receptor protein, it is universal that the protein is a GPCR and interacts with G proteins to produce one or more secondary signals, in a variety of intracellular signal transduction pathways, e.g., through phosphatidylinositol or cyclic AMP metabolism and turnover, in a cell.

As used herein, "phosphatidylinositol turnover and metabolism" refers to the molecules involved in the turnover and metabolism of phosphatidylinositol 4,5-bisphosphate (PIP₂) as well as to the activities of these molecules. PIP₂ is a phospholipid found in the cytosolic leaflet of the plasma membrane. Binding of ligand to the receptor activates, in some cells, the plasma-membrane enzyme phospholipase C that in turn can hydrolyze PIP to produce 1 ,2-diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP₃). Once formed IP₃ can diffuse to the endoplasmic reticulum surface where it can bind an IP₃ receptor, e.g., a calcium channel protein containing an IP binding site. IP₃ binding can induce opening of the channel, allowing calcium ions to be released into the cytoplasm. IP₃ can also be phosphorylated by a specific kinase to form inositol 1,3,4,5-tetraphosphate (IP₄), a molecule that can cause calcium entry into the cytoplasm from the extracellular medium. IP₃ and IP₄can subsequently be hydrolyzed very rapidly to the inactive products inositol 1 ,4-biphosphate (IP₂) and inositol 1,3,4-triphosphate, respectively. These inactive products can be recycled by the cell to synthesize PIP₂. The other second messenger produced by the hydrolysis of PIP , namely 1 ,2-diacylglycerol (DAG), remains in the cell membrane where it can serve to activate the enzyme protein kinase C. Protein kinase C is usually found soluble in the cytoplasm of the cell, but upon an increase in the intracellular calcium concentration, this enzyme can move to the plasma membrane where it can be activated by DAG. The activation of protein kinase C in different cells results in various cellular responses such as the phosphorylation of glycogen synthase, or the phosphorylation of various transcription factors, e.g., NF-kB. The language "phosphatidylinositol activity", as used herein, refers to an activity of PIP₂ or one of its metabolites. Another signaling pathway in which the receptor may participate is the cAMP turnover pathway. As used herein, "cyclic AMP turnover and metabolism" refers to the molecules involved in the turnover and metabolism of cyclic AMP (cAMP) as well as to the activities of these molecules. Cyclic AMP is a second messenger produced in response to ligand-induced stimulation of certain G protein coupled receptors. In the cAMP signaling pathway, binding of a ligand to a GPCR can lead to the activation of the enzyme adenyl cyclase, which catalyzes the synthesis of cAMP. The newly synthesized cAMP can in turn activate a cAMP-dependent protein kinase. This activated kinase can phosphorylate a voltage-gated potassium channel protein, or an associated protein, and lead to the inability of the potassium channel to open during an action potential. The inability of the potassium channel to open results in a decrease in the outward flow of potassium, which normally repolarizes the membrane of a neuron, leading to prolonged membrane depolarization.

By targeting an agent to modulate a GPCR, the signaling activity and biological process mediated by the receptor can be agonized or antagonized. Such agonism and antagonism serves as a basis for modulating a biological activity in a therapeutic context (mammalian therapy) or toxic context (anti-invertebrate/insecticidal agent).

DESCRIPTION OF THE FIGURE SHEETS

FIGURE SHEETS 1 -89 provides genomic nucleic acid sequences from Drosophila melanogaster, predicted transcript, amino acid coding regions, information relating to the subfamily of GPCR proteins to which the protein sequence belongs, e.g., BLAST hit homology, presence of hidden Markov model, etc. Also provided are 5' promoter sequences, transciption initiation sites and other structural features.

DETAILED DESCRIPTION OF THE INVENTION

General Description

The present invention is based on the sequencing of the Drosophila melanogaster genome. During the sequencing and assembly of the Drosophila melanogaster genome, analysis of the sequence information revealed previously unidentified nucleic acid molecules that encode proteins that share structural and/or sequence homology to protein/peptide/domains identified and characterized within the art as being a GPCR protein or part of a GPCR protein. Based on this analysis, the present invention provides amino acid sequences of 66 GPCR proteins that are produced by Drosophila melanogaster, nucleic acid sequences that encode these GPCR proteins, and the art known protein/peptide/domain that have structural or sequence homology to the Drosophila melanogaster protein.

In addition to being previously unknown, the proteins and nucleic acid molecules that are provided in the present invention are selected based on their ability to be used for the development of commercially important products and services. Specifically, the present proteins are selected based on homology and/or structural relatedness to known GPCR proteins of commercial importance and/or the presence of genetic signals that define the protein as a GPCR protein. Some of the more specific features of the proteins of the present invention, and the uses thereof, are described in detail below, and are known within the art for each category of GPCR.

Specific Embodiments

Peptide Molecules

In the Figure sheets, the present invention provides nucleic acid sequences that encode 66 protein molecules that have been identified as being within the Drosophila melanogaster genome (SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, encoded by nucleic acid molecules provided in SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191 , 194, 197 (transcript sequences)). These protein sequences will be referred herein as the GPCR proteins of the present invention, GPCR proteins, or the peptides or the proteins of the present invention. Table 1 provides a summary of the GPCRs of the present invention and the subfamily assignment of each one.

The present invention provides isolated peptide and protein molecules that consist of, consist essentially of or are comprised of the amino acid sequences of the GPCR proteins disclosed in the Figure sheets (SEQ ID NO: 3, 6, 9, 189, 192, 195, 198, encoded by nucleic acid molecules provided in SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)), as well as all obvious variants of these proteins that are within the art to make and use. Some of these variants are described in detail below.

As used herein, a protein is said to be "isolated" or "purified" when it is substantially free of cellular material or free of chemical precursors or other chemicals. The proteins of the present invention can be purified to homogeneity or other degrees of purity. The level of purification will be based on the intended use. The critical feature is that the preparation allows for the desired function of the protein, even if in the presence of considerable amounts of other components. In some uses, "substantially free of cellular material" includes preparations of the protein having less than about 30% (by dry weight) other proteins (i.e., contaminating protein), less than about 20% other proteins, less than about 10% other proteins, or less than about 5% other proteins. When the protein is recombinantly produced, it can also be substantially free of culture medium, i.e., culture medium represents less than about 20% of the volume of the protein preparation. The language "substantially free of chemical precursors or other chemicals" includes preparations of the protein in which it is separated from chemical precursors or other chemicals that are involved in its synthesis. In one embodiment, the language "substantially free of chemical precursors or other chemicals" includes preparations of the GPCR protein having less than about 30% (by dry weight) chemical precursors or other chemicals, less than about 20% chemical precursors or other chemicals, less than about 10% chemical precursors or other chemicals, or less than about 5% chemical precursors or other chemicals.

The isolated GPCR protein can be purified from cells that naturally express it, purified from cells that have been altered to express it (recombinant), or synthesized using known protein synthesis methods. For example, a nucleic acid molecule encoding the GPCR protein is cloned into an expression vector, the expression vector introduced into a host cell and the protein expressed in the host cell. The protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. Many of these techniques are described in detail below. Accordingly, the present invention provides proteins that consist of one of the amino acid sequences encoded by the nucleic acid sequences shown in the Figure sheets (SEQ ID NOs: 1 , 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)). The amino acid sequences of such proteins are provided in the Figure Sheets along with an explanation of the protein type/family. A protein consists of an amino acid sequence when the amino acid sequence is the final amino acid sequence of the protein.

The present invention further provides proteins that consist essentially of one of the amino acid sequences encoded by the nucleic acid sequences shown in the Figure sheets (SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)). A protein consists essentially of an amino acid sequence when such an amino acid sequence is present with only a few additional amino acid residues in the final protein. The present invention further provides proteins that are comprised of one of the amino acid sequences encoded by the nucleic acid sequences shown in the Figure sheets (SEQ ID NOs: 1 , 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)). A protein is comprised of an amino acid sequence when the amino acid sequence is at least part of the final amino acid sequence of the protein. In such a fashion, the protein can be only the protein or have additional amino acid molecules, such as amino acid residues (contiguous encoded sequence) that are naturally associated with it or heterologous amino acid residues/peptide sequences. Such a protein can have a few additional amino acid residues or can comprise several hundred or more additional amino acids. The preferred classes of proteins that are comprised of the GPCR proteins of the present invention are the naturally occurring mature proteins.

The GPCR proteins of the present invention can be attached to heterologous sequences to form chimeric or fusion proteins. Such chimeric and fusion proteins comprise a GPCR protein operatively linked to a heterologous protein having an amino acid sequence not substantially homologous to the GPCR protein. "Operatively linked" indicates that the GPCR protein and the heterologous protein are fused in-frame. The heterologous protein can be fused to the N-terminus or C-terminus of the GPCR protein.

In some uses, the fusion protein does not affect the activity of the GPCR protein er se. For example, the fusion protein can include, but is not limited to, enzymatic fusion proteins, for example beta-galactosidase fusions, yeast two-hybrid GAL fusions, poly-His fusions, MYC-tagged, HI- tagged and Ig fusions. Such fusion proteins, particularly poly-His fusions, can facilitate the purification of recombinant GPCR protein. In certain host cells (e.g., mammalian host cells), expression and or secretion of a protein can be increased by using a heterologous signal sequence. A chimeric or fusion protein can be produced by standard recombinant DNA techniques.

For example, DNA fragments coding for the different protein sequences are ligated together in- frame in accordance with conventional techniques. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and re-amplified to generate a chimeric gene sequence (see Ausubel et al, Current Protocols in Molecular Biology, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST protein). A GPCR protein-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in- frame to the GPCR protein.

As mentioned above, the present invention also provides and enables obvious variants of the amino acid sequence of the proteins of the present invention, such as naturally occurring mature forms of the protein, allelic/sequence variants of the proteins, non-naturally occurring recombinantly derived variants of the proteins, and orthologs and paralogs of the proteins. Such variants can readily be generated using art know techniques in the fields of recombinant nucleic acid technology and protein biochemistry. It is understood, however, that variants exclude any amino acid sequences disclosed prior to the invention. Such variants can readily be identified/made using molecular techniques and the sequence information disclosed herein. Further, such variants can readily be distinguished from other proteins based on sequence and/or structural homology to the GPCR proteins of the present invention. The degree of homology/identity present will be based primarily on whether the protein is a functional variant or non-functional variant, the amount of divergence present in the paralog family and the evolutionary distance between the orthologs.

To determine the percent identity of two amino acid sequences or two nucleic acid sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In a preferred embodiment, the length of a reference sequence aligned for comparison purposes is at least 30%, 40%, 50%, 60%, 70%, 80%, or 90% or more of the length of the reference sequence. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein amino acid or nucleic acid "identity" is equivalent to amino acid or nucleic acid "homology"). The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences. The comparison of sequences and determination of percent identity and similarity between two sequences can be accomplished using a mathematical algorithm. (Computational Molecular Biology, Lesk, A.M., ed., Oxford University Press, New York, 1988; Biocomputing: Informatics and Genome Projects, Smith, D.W., ed., Academic Press, New York, 1993; Computer Analysis of Sequence Data, Part 1, Griffin, A.M., and Griffin, H.G., eds., Humana Press, New Jersey, 1994; Sequence Analysis in Molecular Biology, von Heinje, G., Academic Press, 1987; and Sequence Analysis Primer, Gribskov, M. and Devereux, J., eds., M Stockton Press, New York, 1991). In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch (J. Mol. Biol. (48):444-453 (1970)) algorithm which has been incoφorated into the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blossom 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1 , 2, 3, 4, 5, or 6. In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package (Devereux, J., et al, Nucleic Acids Res. 12(1):387 (1984)) (available at http://www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, A, 5, or 6. In another embodiment, the percent identity between two amino acid or nucleotide sequences is determined using the algorithm of E. Meyers and W. Miller (CABIOS, 4:11-17 (1989)) which has been incoφorated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4.

The nucleic acid and protein sequences of the present invention can further be used as a "query sequence" to perform a search against sequence databases to, for example, identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (J. Mol. Biol 215:403-10 (1990)). BLAST nucleotide searches can be performed with the NBLAST program, score = 100, wordlength = 12 to obtain nucleotide sequences homologous to the nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score = 50, wordlength = 3 to obtain amino acid sequences homologous to the proteins of the invention. To obtain gapped alignments for comparison puφoses, Gapped BLAST can be utilized as described in Altschul et al. (Nucleic Acids Res. 25(17):3389-3402 (1997)). When utilizing BLAST and gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used. See http://www.ncbi.nlm.nih.gov.

Full-length pre-processed forms, as well as mature processed forms, of proteins that comprise one of the proteins of the present invention can readily be identified as having complete sequence identity to one of the GPCR proteins of the present invention as well as being encoded by the same genetic locus as the GPCR protein provided herein.

Allelic variants of a GPCR protein can readily be identified as having a high degree (significant) of sequence homology/identity to at least a portion of the GPCR protein as well as being encoded by the same genetic locus as the GPCR protein provided herein. As used herein, two proteins (or a region of the proteins) have significant homology when the amino acid sequences are typically at least about 70-75%, 80-85%, and more typically at least about 90-95% or more homologous. A significantly homologous amino acid sequence, according to the present invention, will be encoded by a nucleic acid sequence that will hybridize to a GPCR protein encoding nucleic acid molecule under stringent conditions as more fully described below.

Paralogs of a GPCR protein can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the GPCR protein, as being encoded by a gene from Drosophila, and as having similar activity or function. Two proteins will typically be considered paralogs when the amino acid sequences are typically at least about 70-75%, 80-85%, and more typically at least about 90-95% or more homologous through a given region or domain. Such paralogs will be encoded by a nucleic acid sequence that will hybridize to a GPCR protein encoding nucleic acid molecule under stringent conditions as more fully described below. Orthologs of a GPCR protein can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the GPCR protein as well as being encoded by a gene from another organism. Preferred orthologs will be isolated from mammals, preferably human, for the development of human therapeutic targets and agents, or other invertebrates, particularly insects of economical/agriculture importance, e.g. members of the Lepidopteran and Coleopteran orders, for the development of insecticides and insecticidal targets. Such orthologs will be encoded by a nucleic acid sequence that will hybridize to a GPCR protein encoding nucleic acid molecule under moderate to stringent conditions, as more fully described below, depending on the degree of relatedness of the two organisms yielding the proteins.

Non-naturally occurring variants of the GPCR proteins of the present invention can readily be generated using recombinant techniques. Such variants include, but are not limited to deletions, additions and substitutions in the amino acid sequence of the GPCR protein. For example, one class of substitutions are conserved amino acid substitution. Such substitutions are those that substitute a given amino acid in a GPCR protein by another amino acid of like characteristics. Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu, and He; interchange of the hydroxyl residues Ser and Thr, exchange of the acidic residues Asp and Glu, substitution between the amide residues Asn and Gin, exchange of the basic residues Lys and Arg and replacements among the aromatic residues Phe, Tyr. Guidance concerning which amino acid changes are likely to be phenotypically silent are found in Bowie et al, Science 247:1306-1310 (1990). Variant GPCR proteins can be fully functional or can lack function in one or more activities, e.g. ability to bind ligand, ability to bind G-protein, ability to mediate signaling, etc. Fully functional variants typically contain only conservative variation or variation in non-critical residues or in non-critical regions. Functional variants can also contain substitution of similar amino acids that result in no change or an insignificant change in function. Alternatively, such substitutions may positively or negatively affect function to some degree.

Non-functional variants typically contain one or more non-conservative amino acid substitutions, deletions, insertions, inversions, or truncation or a substitution, insertion, inversion, or deletion in a critical residue or critical region.

Amino acids that are essential for function can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis (Cunningham et al, Science 244:1081-1085 (1989)). The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity such as receptor binding or in assays such as an in vitro proliferative activity. Sites that are critical for ligand- receptor binding can also be determined by structural analysis such as crystallization, nuclear magnetic resonance or photoaffinity labeling (Smith et al, J. Mol. Biol. 224:899-904 (1992); de Vos et al. Science 255:306-312 (1992)).

Polypeptides often contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally-occurring amino acids. Further, many amino acids, including the terminal amino acids, may be modified by natural processes, such as processing and other post-translational modifications, or by chemical modification techniques well known in the art. Common modifications that occur naturally in polypeptides are described in basic texts, detailed monographs, and the research literature, and they are well known to those of skill in the art. Accordingly, the polypeptides also encompass derivatives or analogs in which a substituted amino acid residue is not one encoded by the genetic code, in which a substituent group is included, in which the mature polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (for example, polyethylene glycol), or in which the additional amino acids are fused to the mature polypeptide, such as a leader or secretory sequence or a sequence for purification of the mature polypeptide or a pro-protein sequence.

The present invention further provides fragments of the GPCR proteins, in addition to proteins and peptides that comprise and consist of such fragments. The fragments to which the invention pertains, however, are not to be construed as encompassing fragments that may be disclosed publicly prior to the present invention. As used herein, a fragment comprises at least 8 or more contiguous amino acid residues from a GPCR protein. Such fragments can be chosen based on the ability to retain one or more of the biological activities of the GPCR protein or could be chosen for the ability to perform a function, e.g. act as an immunogen. Particularly important fragments are biologically active fragments, peptides which are, for example, about 8 or more amino acids in length. Such fragments will typically comprise a domain or motif of the GPCR protein, e.g., active site, a G-protein binding site, a transmembrane domain or a ligand binding domain. Further, possible fragments include, but are not limited to, domain or motif containing fragments, soluble peptide fragments, and fragments containing immunogenic structures. Predicted domains and functional sites are readily identifiable by computer programs well-known and readily available to those of skill in the art (e.g., PROSITE analysis).

Polypeptides often contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally-occurring amino acids. Further, many amino acids, including the terminal amino acids, may be modified by natural processes, such as processing and other post-translational modifications, or by chemical modification techniques well known in the art. Common modifications that occur naturally in GPCR proteins are described in basic texts, detailed monographs, and the research literature, and they are well known to those of skill in the art.

Accordingly, the GPCR proteins of the present invention also encompass derivatives or analogs in which a substituted amino acid residue is not one encoded by the genetic code, in which a substituent group is included, in which the mature GPCR protein is fused with another compound, such as a compound to increase the half-life of the GPCR protein (for example, polyethylene glycol), or in which the additional amino acids are fused to the mature GPCR protein, such as a leader or secretory sequence or a sequence for purification of the mature GPCR protein or a pro- protein sequence.

Known modifications include, but are not limited to, acetylation, acylation, ADP- ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent crosslinks, formation of cystine, formation of pyroglutamate, formylation, gamma carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination. Such modifications are well-known to those of skill in the art and have been described in great detail in the scientific literature. Several particularly common modifications, glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation, for instance, are described in most basic texts, such as Proteins - Structure and Molecular Properties, 2nd Ed., T.E. Creighton, W. H. Freeman and Company, New York (1993). Many detailed reviews are available on this subject, such as by Wold, F., Posttranslational Covalent Modification of Proteins, B.C. Johnson, Ed., Academic Press, New York 1-12 (1983); Seifter et al. (Meth. Enzymol. 182: 626-646 (1990)) and Rattan et al. (Ann. NY. Acad. Sci. 663:48-62 (1992)).

Protein/Peptide Uses

The proteins of the present invention can be used in assays to identify modulators as potential insecticides, to determine the biological activity of the protein, including in a panel of multiple proteins for high-throughput screening; to raise antibodies or to elicit another immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the protein (or its binding partner or receptor) in biological fluids; and as markers for tissues in which the corresponding protein is preferentially expressed. Where the protein binds or potentially binds to another protein (such as, for example, in a receptor-ligand interaction), the protein can be used to identify the binding partner so as to develop a system to identify inhibitors of the binding interaction. Any or all of these research utilities are capable of being developed into reagent grade or kit format for commercialization as research products.

Methods for performing the uses listed above are well known to those skilled in the art. References disclosing such methods include "Molecular Cloning: A Laboratory Manual", 2d ed., Cold Spring Harbor Laboratory Press, Sambrook, J., E. F. Fritsch and T. Maniatis eds., 1989, and "Methods in Enzymology: Guide to Molecular Cloning Techniques", Academic Press,

Berger, S. L. and A. R. Kimmel eds., 1987 and can readily be determined using the information provided in Table 1.

The potential uses of the proteins of the present invention are based primarily on the source of the protein as well as the class/action of the protein. For example, GPCRs isolated from Drosophila and other invertebrates serve as a target for identifying anti-invertebrate compounds, e.g. insecticides. GPCRs isolated from Drosophila and their human/mammalian orthologs serve as targets for identifying agents for use in mammalian therapeutic applications, e.g. a human drug. Approximately 70% of all pharmaceutical agents modulate the activity of a GPCR. A combination of the invertebrate and mammalian ortholog can be used in selective screening methods to find agents specific for invertebrates. Table 1 provides specific context of use for each of the presently disclosed GPCRs. Particularly useful are GPCRs involved in neurotransmission for use as insecticide targets. The receptor polypeptides (including variants and fragments which may have been disclosed prior to the present invention) are useful for biological assays related to GPCRs. Such assays involve any of the known GPCR functions or activities or properties useful for diagnosis and treatment of GPCR-related conditions. The receptor polypeptides are also useful in drug/insecticide screening assays, in cell-based or cell-free systems. Cell-based systems can be native, i.e., cells that normally express the receptor protein, as a biopsy or expanded in cell culture. In one embodiment, however, cell-based assays involve recombinant host cells expressing the receptor protein.

The polypeptides can be used to identify compounds that modulate receptor activity. Both the GPCRs of the present invention and appropriate variants and fragments can be used in high- throughput screens to assay candidate compounds for the ability to bind to the receptor. These compounds can be further screened against a functional receptor to determine the effect of the compound on the receptor activity. Further, these compounds can be tested in animal or invertebrate systems to determine activity/effectiveness. Compounds can be identified that activate (agonist) or inactivate (antagonist) the receptor to a desired degree.

Further, the receptor polypeptides can be used to screen a compound for the ability to stimulate or inhibit interaction between the receptor protein and a target molecule that normally interacts with the receptor protein. The target can be ligand or a component of the signal pathway that the receptor protein normally interacts (for example, a G-protein or other interactor involved in cAMP or phosphatidylinositol turnover and/or adenylate cyclase, or phospholipase C activation). Such assays typically include the steps of combining the receptor protein with a candidate compound under conditions that allow the receptor protein, or fragment, to interact with the target molecule, and to detect the formation of a complex between the protein and the target or to detect the biochemical consequence of the interaction with the receptor protein and the target, such as any of the associated effects of signal transduction such as G-protein phosphorylation, cAMP or phosphatidylinositol turnover, and adenylate cyclase or phospholipase C activation.

Candidate compounds include, for example, 1) peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam et al, Nature 354:82-84 (1991); Houghten et al, Nature 354:84-86 (1991)) and combinatorial chemistry-derived molecular libraries made of D- and/or L- configuration amino acids; 2) phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang et al, Cell 72:161-118 (1993)); 3) antibodies (e.g., polyclonal, monoclonal, humanized, anti- idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab') , Fab expression library fragments, and epitope-binding fragments of antibodies); and 4) small organic and inorganic molecules (e.g., molecules obtained from combinatorial and natural product libraries).

One candidate compound is a soluble fragment of the receptor that competes for ligand binding. Other candidate compounds include mutant receptors or appropriate fragments containing mutations that affect receptor function and thus compete for ligand. Accordingly, a fragment that competes for ligand, for example with a higher affinity, or a fragment that binds ligand but does not allow release, is encompassed by the invention.

The invention further includes other end point assays to identify compounds that modulate (stimulate or inhibit) receptor activity. The assays typically involve an assay of events in the signal transduction pathway that indicate receptor activity. Thus, the expression of genes that are up- or down-regulated in response to the receptor protein dependent signal cascade can be assayed. In one embodiment, the regulatory region of such genes can be operably linked to a marker that is easily detectable, such as luciferase. Alternatively, phosphorylation of the receptor protein, or a receptor protein target, could also be measured. Any of the biological or biochemical functions mediated by the receptor can be used as an endpoint assay. These include all of the biochemical or biochemical/biological events described herein, in the references cited herein, incoφorated by reference for these endpoint assay targets, and other functions known to those of ordinary skill in the art.

Binding and/or activating compounds can also be screened by using chimeric receptor proteins in which the amino terminal extracellular domain, or parts thereof, the entire transmembrane domain or subregions, such as any of the seven transmembrane segments or any of the intracellular or extracellular loops and the carboxy terminal intracellular domain, or parts thereof, can be replaced by heterologous domains or subregions. For example, a G-protein-binding region can be used that interacts with a different G-protein then that which is recognized by the native receptor. Accordingly, a different set of signal transduction components is available as an end-point assay for activation. Alternatively, the entire transmembrane portion or subregions (such as transmembrane segments or intracellular or extracellular loops) can be replaced with the entire transmembrane portion or subregions specific to a host cell that is different from the host cell from which the amino terminal extracellular domain and/or the G-protein-binding region are derived. This allows for assays to be performed in other than the specific host cell from which the receptor is derived. Alternatively, the amino terminal extracellular domain (and/or other ligand-binding regions) could be replaced by a domain (and/or other binding region) binding a different ligand, thus, providing an assay for test compounds that interact with the heterologous amino terminal extracellular domain (or region) but still cause signal transduction. Finally, activation can be detected by a reporter gene containing an easily detectable coding region operably linked to a transcriptional regulatory sequence that is part of the native signal transduction pathway.

The receptor polypeptides are also useful in competition binding assays in methods designed to discover compounds that interact with the receptor. Thus, a compound is exposed to a receptor polypeptide under conditions that allow the compound to bind or to otherwise interact with the polypeptide. Soluble receptor polypeptide is also added to the mixture. If the test compound interacts with the soluble receptor polypeptide, it decreases the amount of complex formed or activity from the receptor target. This type of assay is particularly useful in cases in which compounds are sought that interact with specific regions of the receptor. Thus, the soluble polypeptide that competes with the target receptor region is designed to contain peptide sequences corresponding to the region of interest.

To perform cell free drug/insecticide screening assays, it is sometimes desirable to immobilize either the receptor protein, or fragment, or its target molecule to facilitate separation of complexes from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay.

Techniques for immobilizing proteins on matrices can be used in the drug/insecticide screening assays. In one embodiment, a fusion protein can be provided which adds a domain that allows the protein to be bound to a matrix. For example, glutathione-S-transferase/15625 fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, MO) or glutathione derivatized microtitre plates, which are then combined with the cell lysates (e.g., ³⁵S- labeled) and the candidate compound, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads are washed to remove any unbound label, and the matrix immobilized and radiolabel determined directly, or in the supernatant after the complexes are dissociated. Alternatively, the complexes can be dissociated from the matrix, separated by SDS-PAGE, and the level of receptor- binding protein found in the bead fraction quantitated from the gel using standard electrophoretic techniques. For example, either the polypeptide or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin using techniques well known in the art. Alternatively, antibodies reactive with the protein but which do not interfere with binding of the protein to its target molecule can be derivatized to the wells of the plate, and the protein trapped in the wells by antibody conjugation. Preparations of a receptor-binding protein and a candidate compound are incubated in the receptor protein-presenting wells and the amount of complex trapped in the well can be quantitated. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the receptor protein target molecule, or which are reactive with receptor protein and compete with the target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the target molecule.

Agents that modulate one of the GPCRs of the present invention can be identified using one or more of the above assays, alone or in combination. It is generally preferable to use a cell-based or cell free system first and then confirm activity in an animal/insect model system. Such model systems are well known in the art and can readily be employed in this context. Modulators of receptor protein activity identified according to these drug/insecticide screening assays can be used to treat a subject with a disorder mediated by the receptor pathway, by treating cells that express the GPCR. These methods of treatment include the steps of administering the modulators of protein activity in a pharmaceutical composition as described herein, to a subject in need of such treatment. In yet another aspect of the invention, the GPCR proteins can be used as "bait proteins" in a two-hybrid assay or three-hybrid assay (see, e.g., U.S. Patent No. 5,283,317; Zervos et al. (1993) Cell 72:223-232; Madura et al. (1993) J Biol. Chem. 268:12046-12054; Bartel et al. (1993) Biotechniques 14:920-924; Iwabuchi et al. (1993) Oncogene 8:1693-1696; and Brent WO94/ 10300), to identify other proteins, which bind to or interact with the GPCR and are involved in GPCR activity. Such GPCR-binding proteins are also likely to be involved in the propagation of signals by the GPCR proteins or GPCR targets as, for example, downstream elements of a GPCR-mediated signaling pathway, e.g., a signaling pathway. Alternatively, such GPCR-binding proteins are likely to be GPCR inhibitors.

The two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for a GPCR protein is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein ("prey" or "sample") is fused to a gene that codes for the activation domain of the known transcription factor. If the "bait" and the "prey" proteins are able to interact, in vivo, forming a GPCR-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) which is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene which encodes the protein which interacts with the GPCR protein.

This invention further pertains to novel agents identified by the above-described screening assays. Accordingly, it is within the scope of this invention to further use an agent identified as described herein in an appropriate animal model. For example, an agent identified as described herein (e.g., a GPCR modulating agent, an antisense GPCR nucleic acid molecule, a GPCR-specific antibody, or a GPCR-binding partner) can be used in an animal or insect model to determine the efficacy, toxicity, or side effects of treatment with such an agent. Alternatively, an agent identified as described herein can be used in an animal or insect model to determine the mechanism of action of such an agent. Furthermore, this invention pertains to uses of novel agents identified by the above-described screening assays for insecticidal activity as described herein.

Antibodies

The invention also provides antibodies that selectively bind to one of the proteins of the present invention, a protein comprising such a peptide, as well as variants and fragments thereof.

As used herein, an antibody selectively binds a target peptide when it binds the target peptide and does not significantly bind to unrelated proteins. An antibody is still considered to selectively bind a peptide even if it also binds to other proteins that are not substantially homologous with the target peptide so long as such proteins share homology with a fragment or domain of the peptide target of the antibody. In this case, it would be understood that antibody binding to the peptide is still selective despite some degree of cross-reactivity.

As used herein, an antibody is defined in terms consistent with that recognized within the art: they are multi-subunit proteins produced by a mammalian organism in response to an antigen challenge. The antibodies of the present invention include polyclonal antibodies and monoclonal antibodies, as well as fragments of such antibodies, including, but not limited to, Fab or F(ab')₂, and

Fv fragments.

Many methods are known for generating and/or identifying antibodies to a given target peptide. Several such methods are described by Harlow, Antibodies, Cold Spring Harbor Press,

(1989). In general, to generate antibodies, an isolated peptide is used as an immunogen and is administered to a mammalian organism, such as a rat, rabbit or mouse. Either the full-length protein, an antigenic peptide fragment or a fusion protein can be used.

Antibodies are preferably prepared from regions or discrete fragments of the GPCR proteins. Antibodies can be prepared from any region of the protein as described herein. However, preferred regions will include those involved in function/activity and/or receptor/binding partner interaction.

An antigenic fragment will typically comprise at least 10 contiguous amino acid residues. The antigenic peptide can comprise, however, at least 12, 14, 20 or more amino acid residues. Such fragments can be selected on a physical property, such as fragments correspond to regions that are located on the surface of the protein, e.g., hydrophilic regions or can be selected based on sequence uniqueness.

Detection on an antibody of the present invention can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include ¹²⁵I, ^l311, ³⁵S or ³H.

Antibody Uses The antibodies can be used to isolate one of the proteins of the present invention by standard techniques, such as affinity chromatography or immunoprecipitation. The antibodies can facilitate the purification of the natural protein from cells and recombinantly produced protein expressed in host cells. In addition, such antibodies are useful to detect the presence of one of the proteins of the present invention in cells or tissues to determine the pattern of expression of the protein among various tissues in an organism and over the course of normal development. Further, such antibodies can be used to detect protein in situ, in vitro, or in a cell lysate or supernatant in order to evaluate the abundance and pattern of expression. Also, such antibodies can be used to assess abnormal tissue distribution or abnormal expression during development. Antibody detection of circulating fragments of the full length protein can be used to identify turnover.

The antibodies can also be used to assess normal and aberrant subcellular localization of cells in the various tissues in an organism. The diagnostic uses can be applied, not only in genetic testing, but also in monitoring a treatment modality. Accordingly, where treatment is ultimately aimed at correcting expression level or the presence of aberrant sequence and aberrant tissue distribution or developmental expression, antibodies directed against the or relevant fragments can be used to monitor therapeutic efficacy.

The antibodies are also useful for inhibiting protein function, for example, blocking the binding of the GPCR protein to a binding partner such as a ligand. An antibody can be used, for example, to block binding, thus modulating (agonizing or antagonizing) the peptides activity. Antibodies can be prepared against specific fragments containing sites required for function or against intact protein that is associated with a cell or cell membrane.

The invention also encompasses kits for using antibodies to detect the presence of a protein in a biological sample. The kit can comprise antibodies such as a labeled or labelable antibody and a compound or agent for detecting protein in a biological sample; means for determining the amount of protein in the sample; means for comparing the amount of protein in the sample with a standard; and instructions for use.

Nucleic Acid Molecules

The present invention further provides isolated nucleic acid molecules that encode a GPCR protein or protein of the present invention (SEQ ID NO: 3, 6, 9, . . . , 192, 195, 198, encoded by nucleic acid molecules provided in SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)). Such nucleic acid molecules will consist of, consist essentially of, or comprise a nucleotide sequence that encodes one of the GPCR proteins of the present invention, an allelic variant thereof, or an ortholog or paralog thereof.

As used herein, an "isolated" nucleic acid molecule is one that is separated from other nucleic acid present in the natural source of the nucleic acid. Preferably, an "isolated" nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5' and 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. However, there can be some flanking nucleotide sequences, for example up to about 5KB, 4KB, 3KB, 2KB, or 1KB or less, particularly contiguous protein encoding sequences and protein encoding sequences within the same gene but separated by introns in the genomic sequence. The important point is that the nucleic acid is isolated from remote and unimportant flanking sequences such that it can be subjected to the specific manipulations described herein such as recombinant expression, preparation of probes and primers, and other uses specific to the nucleic acid sequences. Moreover, an "isolated" nucleic acid molecule, such as a cDNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. However, the nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered isolated. For example, recombinant DNA molecules contained in a vector are considered isolated.

Further examples of isolated DNA molecules include recombinant DNA molecules maintained in heterologous host cells or purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the isolated DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically.

Accordingly, the present invention provides nucleic acid molecules that consist of one of the nucleotide sequences shown in the Figure sheets (SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191 , 194, 197 (transcript sequences)). A nucleic acid molecule consists of a nucleotide sequence when the nucleotide sequence is the complete nucleotide sequence of the nucleic acid molecule.

The present invention further provides nucleic acid molecules that consist essentially of one of the nucleotide sequences shown in the Figure sheets (SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)). A nucleic acid molecule consists essentially of a nucleotide sequence when such a nucleotide sequence is present with only a few additional nucleic acid residues in the final nucleic acid molecule.

The present invention further provides nucleic acid molecules that are comprised of one of the nucleotide sequences shown in the Figure sheets (SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)). A nucleic acid molecule is comprised of a nucleotide sequence when the nucleotide sequence is at least part of the final nucleotide sequence of the nucleic acid molecule. In such a fashion, the nucleic acid molecule can be only the nucleotide sequence or have additional nucleic acid residues, such as nucleic acid residues that are naturally associated with it or heterologous nucleotide sequences. Such a nucleic acid molecule can have a few additional nucleotides or can comprises several hundred or more additional nucleotides. The preferred classes of nucleic acid molecules that are comprised of the nucleotide sequences of the present are the naturally occurring full-length cDNA molecules and genes and genomic clones since some of the nucleic acid molecules provided in the Figure sheets are fragments of the complete gene that exists in nature. A brief description of how various types of these nucleic acid molecules can be readily made/isolated is provided below.

In the Figures, both coding and non-coding sequences are provided for each protein encoding nucleic acid sequence. Because of the source of the present invention, Drosophila genomic sequences, the nucleic acid molecules in the figures will contain genomic intronic sequences, 5' and 3' non-coding sequences, gene regulatory regions and non-coding intergenic sequences. In general such sequence features are either noted or can readily be identified using computational tools known in the art. As discussed below, some of the non-coding regions, particularly gene regulatory elements such as promoters, are useful for a variety of puφoses, e.g. control of heterologous gene expression, target for identifying gene activity modulating compounds.

Full-length genes may be cloned from known sequence using any one of a number of methods known in the art. For example, a method which employs XL-PCR (Perkin-Elmer, Foster City, Calif.) to amplify long pieces of DNA may be used. Other methods for obtaining full-length sequences are well known in the art. The isolated nucleic acid molecules can encode the mature protein plus additional amino or carboxyl-terminal amino acids, or amino acids interior to the mature protein (when the mature form has more than one protein chain, for instance). Such sequences may play a role in processing of a protein from precursor to a mature form, facilitate protein trafficking, prolong or shorten protein half-life or facilitate manipulation of a protein for assay or production, among other things. As generally is the case in situ, the additional amino acids may be processed away from the mature protein by cellular enzymes.

As mentioned above, the isolated nucleic acid molecules include, but are not limited to, the sequence encoding the GPCR protein alone, the sequence encoding the mature protein and additional coding sequences, such as a leader or secretory sequence (e.g., a pre-pro or pro-protein sequence), the sequence encoding the mature protein, with or without the additional coding sequences, plus additional non-coding sequences, for example introns and non-coding 5' and 3' sequences such as transcribed but non-translated sequences that play a role in transcription, mRNA processing (including splicing and polyadenylation signals), ribosome binding and stability of mRNA. In addition, the nucleic acid molecule may be fused to a marker sequence encoding, for example, a protein that facilitates purification.

Isolated nucleic acid molecules can be in the form of RNA, such as mRNA, or in the form DNA, including cDNA and genomic DNA obtained by cloning or produced by chemical synthetic techniques or by a combination thereof. The nucleic acid, especially DNA, can be double-stranded or single-stranded. Single-stranded nucleic acid can be the coding strand (sense strand) or the non- coding strand (anti-sense strand).

The invention further provides nucleic acid molecules that encode fragments of the proteins of the present invention as well as nucleic acid molecules that encode obvious variants of the GPCR proteins of the present invention that are described above. Such nucleic acid molecules may be naturally occurring, such as allelic variants (same locus), paralogs (different locus), and orthologs (different organism), or may be constructed by recombinant DNA methods or by chemical synthesis. Such non-naturally occurring variants may be made by mutagenesis techniques, including those applied to nucleic acid molecules, cells, or organisms. Accordingly, as discussed above, the variants can contain nucleotide substitutions, deletions, inversions and insertions. Variation can occur in either or both the coding and non-coding regions. The variations can produce both conservative and non-conservative amino acid substitutions.

The present invention further provides non-coding fragments of the nucleic acid molecules provided in the Figures. Preferred non-coding fragments include, but are not limited to, promoter sequences, enhancer sequences, gene modulating sequences and gene termination sequences. Such fragments are useful in controlling heterologous gene expression and in developing screens to identify gene modulating agents. Particularly useful are fragments from about 100 to about 1,000 nucleotides taken 5' from the start ATG in the genomic sequences provided in the Figures (SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196, ). A fragment comprises a contiguous nucleotide sequence greater than 12 or more nucleotides. Further, a fragment could at least 30, 40, 50, 100, 250 or 500 nucleotides in length. The length of the fragment will be based on its intended use. For example, the fragment can encode epitope bearing regions of the protein, or can be useful as DNA probes and primers. Such fragments can be isolated using the known nucleotide sequence to synthesize an oligonucleotide probe. A labeled probe can then be used to screen a cDNA library, genomic DNA library, or mRNA to isolate nucleic acid corresponding to the coding region. Further, primers can be used in PCR reactions to clone specific regions of gene. A probe/primer typically comprises substantially a purified oligonucleotide or oligonucleotide pair. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, 20, 25, 40, 50 or more consecutive nucleotides. Orthologs, homologs, and allelic variants can be identified using methods well known in the art. As described in the protein Section, these variants comprise a nucleotide sequence encoding a protein that is typically 60-65%, 70-75%, 80-85%, and more typically at least about 90-95% or more homologous to the nucleotide sequence shown in the Figure sheets or a fragment of this sequence. Such nucleic acid molecules can readily be identified as being able to hybridize under moderate to stringent conditions, to the nucleotide sequence shown in the Figure sheets or a fragment of the sequence.

As used herein, the term "hybridizes under stringent conditions" is intended to describe conditions for hybridization and washing under which nucleotide sequences encoding a protein at least 50-55% homologous to each other typically remain hybridized to each other. The conditions can be such that sequences at least about 65%, at least about 70%, or at least about 75% or more homologous to each other typically remain hybridized to each other. Such stringent conditions are known to those skilled in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. One example of stringent hybridization conditions are hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45C, followed by one or more washes in 0.2 X SSC, 0.1% SDS at 50-65C.

Nucleic Acid Molecule Uses

The nucleic acid molecules of the present invention are useful for probes, primers, chemical intermediates, and in biological assays. The nucleic acid molecules are useful as a hybridization probe for cDNA and genomic DNA to isolate fiill-length cDNA and genomic clones encoding the protein described in the Figures and to isolate cDNA and genomic clones that correspond to variants (alleles, orthologs, etc.) producing the same or related proteins shown in the Figures.

The probe can correspond to any sequence along the entire length of the nucleic acid molecules provided in the Figures. Accordingly, it could be derived from 5' noncoding regions, the coding region, and 3' noncoding regions. However, as discussed, fragments are not to be construed as encompassing fragments disclosed prior to the present invention. The nucleic acid molecules are also useful as primers for PCR to amplify any given region of a nucleic acid molecule and are useful to synthesize antisense molecules of desired length and sequence.

The nucleic acid molecules are also useful for constructing recombinant vectors. Such vectors include expression vectors that express a portion of, or all of, the protein sequences. Vectors also include insertion vectors, used to integrate into another nucleic acid molecule sequence, such as into the cellular genome, to alter in situ expression of a gene and/or gene product. For example, an endogenous coding sequence can be replaced via homologous recombination with all or part of the coding region containing one or more specifically introduced mutations. The nucleic acid molecules are also useful for expressing antigenic portions of the proteins.

The nucleic acid molecules are also useful in making vectors containing the gene regulatory regions of the nucleic acid molecules of the present invention.

The nucleic acid molecules are also useful for designing ribozymes corresponding to all, or a part, of the mRNA produced from the nucleic acid molecules described herein. The nucleic acid molecules are also useful for constructing host cells expressing a part, or all, of the nucleic acid molecules and proteins.

The nucleic acid molecules are also useful for constructing transgenic animals expressing all, or a part, of the nucleic acid molecules and proteins.

The nucleic acid molecules are also useful for making vectors that express part, or all, of the proteins.

The nucleic acid molecules are also useful as hybridization probes for determining the presence, level, form and distribution of nucleic acid expression. Accordingly, the probes can be used to detect the presence of, or to determine levels of, a specific nucleic acid molecule in cells, tissues, and in organisms. The nucleic acid whose level is determined can be DNA or RNA. Accordingly, probes corresponding to the proteins described herein can be used to assess expression and/or gene copy number in a given cell, tissue, or organism. These uses are relevant for efficacy of insecticides involving an increase or decrease in GPCR protein expression relative to normal results.

In vitro techniques for detection of mRNA include Northern hybridizations and in situ hybridizations. In vitro techniques for detecting DNA includes Southern hybridizations and in situ hybridization.

Probes can be used as a part of a diagnostic test kit for identifying cells or tissues that express a GPCR protein, such as by measuring a level of a receptor-encoding nucleic acid in a sample of cells from a subject e.g., mRNA or genomic DNA, or determining if a receptor gene has been mutated.

Nucleic acid expression assays are useful for drug/insecticide screening to identify compounds that modulate GPCR nucleic acid expression. The invention thus provides a method for identifying a compound that can be used to treat a block the activity of the GPCR by modulating the expression of the GPCR gene. The method typically includes assaying the ability of the compound to modulate the expression of the GPCR nucleic acid and thus identifying a compound that can be used to kill insects by altering GPCR nucleic acid expression. The assays can be performed in cell-based and cell-free systems. Cell- based assays include cells naturally expressing the GPCR nucleic acid or recombinant cells genetically engineered to express specific nucleic acid sequences.

The assay for GPCR nucleic acid expression can involve direct assay of nucleic acid levels, such as mRNA levels, or on collateral compounds involved in the signal pathway. Further, the expression of genes that are up- or down-regulated in response to the GPCR protein signal pathway can also be assayed. In this embodiment the regulatory regions of these genes can be operably linked to a reporter gene such as luciferase.

Thus, modulators of GPCR gene expression can be identified in a method wherein a cell is contacted with a candidate compound and the expression of mRNA determined. The level of expression of GPCR mRNA in the presence of the candidate compound is compared to the level of expression of GPCR mRNA in the absence of the candidate compound. The candidate compound can then be identified as a modulator of nucleic acid expression based on this comparison and be used, for example to treat a disorder characterized by aberrant nucleic acid expression. When expression of mRNA is statistically significantly greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of nucleic acid expression. When nucleic acid expression is statistically significantly less in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of nucleic acid expression.

The nucleic acid molecules are also useful in diagnostic assays for qualitative changes in GPCR nucleic acid, and particularly in qualitative changes that lead to insecticidal activity/tolerance. The nucleic acid molecules can be used to detect mutations in GPCR genes and gene expression products such as mRNA.

The nucleic acid molecules are thus useful as antisense constructs to control GPCR gene expression in cells, tissues, and organisms. A DNA antisense nucleic acid molecule is designed to be complementary to a region of the gene involved in transcription, preventing transcription and hence production of GPCR protein. An antisense RNA or DNA nucleic acid molecule would hybridize to the mRNA and thus block translation of mRNA into GPCR protein.

The invention also encompasses kits for detecting the presence of a GPCR nucleic acid in a biological sample. For example, the kit can comprise reagents such as a labeled or labelable nucleic acid or agent capable of detecting GPCR nucleic acid in a biological sample; means for determining the amount of GPCR nucleic acid in the sample; and means for comparing the amount of GPCR nucleic acid in the sample with a standard. The compound or agent can be packaged in a suitable container. The kit can further comprise instructions for using the kit to detect GPCR protein mRNA or DNA.

Vectors/host cells

The invention also provides vectors containing the nucleic acid molecules described herein. The term "vector" refers to a vehicle, preferably a nucleic acid molecule, that can transport the nucleic acid molecules. When the vector is a nucleic acid molecule, the nucleic acid molecules are covalently linked to the vector nucleic acid. With this aspect of the invention, the vector includes a plasmid, single or double stranded phage, a single or double stranded RNA or DNA viral vector, or artificial chromosome, such as a BAC, PAC, YAC, OR MAC.

A vector can be maintained in the host cell as an extrachromosomal element where it replicates and produces additional copies of the nucleic acid molecules. Alternatively, the vector may integrate into the host cell genome and produce additional copies of the nucleic acid molecules when the host cell replicates.

The invention provides vectors for the maintenance (cloning vectors) or vectors for expression (expression vectors) of the nucleic acid molecules. The vectors can function in procaryotic or eukaryotic cells or in both (shuttle vectors).

Expression vectors contain cis-acting regulatory regions that are operably linked in the vector to the nucleic acid molecules such that transcription of the nucleic acid molecules is allowed in a host cell. The nucleic acid molecules can be introduced into the host cell with a separate nucleic acid molecule capable of affecting transcription. Thus, the second nucleic acid molecule may provide a trans-acting factor interacting with the cis-regulatory control region to allow transcription of the nucleic acid molecules from the vector. Alternatively, a trans-acting factor may be supplied by the host cell. Finally, a trans-acting factor can be produced from the vector itself. It is understood, however, that in some embodiments, transcription and/or translation of the nucleic acid molecules can occur in a cell-free system.

The regulatory sequence to which the nucleic acid molecules described herein can be operably linked include promoters for directing mRNA transcription. These include, but are not limited to, the left promoter from bacteriophage λ, the lac, TRP, and TAC promoters from E. coli, the early and late promoters from SV40, the CMV immediate early promoter, the adenovirus early and late promoters, and retrovirus long-terminal repeats.

In addition to control regions that promote transcription, expression vectors may also include regions that modulate transcription, such as repressor binding sites and enhancers. Examples include the SV40 enhancer, the cytomegalovirus immediate early enhancer, polyoma enhancer, adenovirus enhancers, and retrovirus LTR enhancers.

In addition to containing sites for transcription initiation and control, expression vectors can also contain sequences necessary for transcription termination and, in the transcribed region a ribosome binding site for translation. Other regulatory control elements for expression include initiation and termination codons as well as polyadenylation signals. The person of ordinary skill in the art would be aware of the numerous regulatory sequences that are useful in expression vectors. Such regulatory sequences are described, for example, in Sambrook et al, Molecular Cloning: A Laboratory Manual. 2nd. ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, (1989). A variety of expression vectors can be used to express a nucleic acid molecule. Such vectors include chromosomal, episomal, and virus-derived vectors, for example vectors derived from bacterial plasmids, from bacteriophage, from yeast episomes, from yeast chromosomal elements, including yeast artificial chromosomes, from viruses such as baculoviruses, papovaviruses such as SV40, Vaccinia viruses, adenoviruses, poxviruses, pseudorabies viruses, and retroviruses. Vectors may also be derived from combinations of these sources such as those derived from plasmid and bacteriophage genetic elements, e.g. cosmids and phagemids. Appropriate cloning and expression vectors for prokaryotic and eukaryotic hosts are described in Sambrook et al, Molecular Cloning: A Laboratory Manual. 2nd. ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, (1989). The regulatory sequence may provide constitutive expression in one or more host cells (i.e. tissue specific) or may provide for inducible expression in one or more cell types such as by temperature, nutrient additive, or exogenous factor such as a hormone or other ligand. A variety of vectors providing for constitutive and inducible expression in prokaryotic and eukaryotic hosts are well known to those of ordinary skill in the art.

The nucleic acid molecules can be inserted into the vector nucleic acid by well-known methodology. Generally, the DNA sequence that will ultimately be expressed is joined to an expression vector by cleaving the DNA sequence and the expression vector with one or more restriction enzymes and then ligating the fragments together. Procedures for restriction enzyme digestion and ligation are well known to those of ordinary skill in the art.

The vector containing the appropriate nucleic acid molecule can be introduced into an appropriate host cell for propagation or expression using well-known techniques. Bacterial cells include, but are not limited to, E. coli, Streptomyces, and Salmonella typhimurium. Eukaryotic cells include, but are not limited to, yeast, insect cells such as Drosophila, animal cells such as COS and CHO cells, and plant cells.

As described herein, it may be desirable to express the protein as a fusion protein. Accordingly, the invention provides fusion vectors that allow for the production of the proteins. Fusion vectors can increase the expression of a recombinant protein, increase the solubility of the recombinant protein, and aid in the purification of the protein by acting for example as a ligand for affinity purification. A proteolytic cleavage site may be introduced at the junction of the fusion moiety so that the desired peptide can ultimately be separated from the fusion moiety. Proteolytic enzymes include, but are not limited to, factor Xa, thrombin, and enterokinase. Typical fusion expression vectors include pGEX (Smith et al, Gene 67:31 -40 (1988)), pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which fuse glutathione S- transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al, Gene 69:301-315 (1988)) and pET 1 ld (Studier et al, Gene Expression Technology: Methods in Enzymology 185:60-89 (1990)).

Recombinant protein expression can be maximized in a host bacteria by providing a genetic background wherein the host cell has an impaired capacity to proteolytically cleave the recombinant protein. (Gottesman, S., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128). Alternatively, the sequence of the nucleic acid molecule of interest can be altered to provide preferential codon usage for a specific host cell, for example E. coli. (Wada et al, Nucleic Acids Res. 20:2 11-2118 (1992)).

The nucleic acid molecules can also be expressed by expression vectors that are operative in yeast. Examples of vectors for expression in yeast e.g., S. cerevisiae include pYepSecl (Baldari, et al, EMBO J. 6:229-234 (1987)), pMFa (Kurjan et al, Cell 30:933-943(1982)), pJRY88 (Schultz et al, Gene 54:1 13-123 (1987)), and pYES2 (Invitrogen Coφoration, San Diego, CA).

The nucleic acid molecules can also be expressed in insect cells using, for example, baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., Sf 9 cells) include the pAc series (Smith et al, Mol. Cell Biol. 3:2156-2165 (1983)) and the pVL series (Lucklow et al, Virology 170:31-39 (1989)).

In certain embodiments of the invention, the nucleic acid molecules described herein are expressed in mammalian cells using mammalian expression vectors. Examples of mammalian expression vectors include pCDM8 (Seed, B. Nature 329:840(1987)) and pMT2PC (Kaufman et al, EMBO J. 6:187-195 (1987)).

The expression vectors listed herein are provided by way of example only of the well- known vectors available to those of ordinary skill in the art that would be useful to express the nucleic acid molecules. The person of ordinary skill in the art would be aware of other vectors suitable for maintenance propagation or expression of the nucleic acid molecules described herein. These are found for example in Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.

The invention also encompasses vectors in which the nucleic acid sequences described herein are cloned into the vector in reverse orientation, but operably linked to a regulatory sequence that permits transcription of antisense RNA. Thus, an antisense transcript can be produced to all, or to a portion, of the nucleic acid molecule sequences described herein, including both coding and non-coding regions. Expression of this antisense RNA is subject to each of the parameters described above in relation to expression of the sense RNA (regulatory sequences, constitutive or inducible expression, tissue-specific expression). The invention also relates to recombinant host cells containing the vectors described herein.

Host cells therefore include prokaryotic cells, lower eukaryotic cells such as yeast, other eukaryotic cells such as insect cells, and higher eukaryotic cells such as mammalian cells.

The recombinant host cells are prepared by introducing the vector constructs described herein into the cells by techniques readily available to the person of ordinary skill in the art. These include, but are not limited to, calcium phosphate transfection, DEAE-dextran-mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection, lipofection, and other techniques such as those found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989).

Host cells can contain more than one vector. Thus, different nucleotide sequences can be introduced on different vectors of the same cell. Similarly, the nucleic acid molecules can be introduced either alone or with other nucleic acid molecules that are not related to the nucleic acid molecules such as those providing trans-acting factors for expression vectors. When more than one vector is introduced into a cell, the vectors can be introduced independently, co-introduced or joined to the nucleic acid molecule vector.

In the case of bacteriophage and viral vectors, these can be introduced into cells as packaged or encapsulated virus by standard procedures for infection and transduction. Viral vectors can be replication-competent or replication-defective. In the case in which viral replication is defective, replication will occur in host cells providing functions that complement the defects.

Vectors generally include selectable markers that enable the selection of the subpopulation of cells that contain the recombinant vector constructs. The marker can be contained in the same vector that contains the nucleic acid molecules described herein or may be on a separate vector. Markers include tetracycline or ampicillin-resistance genes for prokaryotic host cells and dihydrofolate reductase or neomycin resistance for eukaryotic host cells. However, any marker that provides selection for a phenotypic trait will be effective.

While the mature proteins can be produced in bacteria, yeast, mammalian cells, and other cells under the control of the appropriate regulatory sequences, cell- free transcription and translation systems can also be used to produce these proteins using RNA derived from the DNA constructs described herein.

Where secretion of the protein is desired, which is difficult to achieve with multi- transmembrane domain containing proteins such as GPCRs, appropriate secretion signals are incoφorated into the vector. The signal sequence can be endogenous to the proteins or heterologous to these proteins.

Where the protein is not secreted into the medium, which is typically the case with GPCRs, the protein can be isolated from the host cell by standard disruption procedures, including freeze thaw, sonication, mechanical disruption, use of lysing agents and the like. The protein can then be recovered and purified by well-known purification methods including ammonium sulfate precipitation, acid extraction, anion or cationic exchange chromatography, phosphocellulose chromatography, hydrophobic-interaction chromatography, affinity chromatography, hydroxylapatite chromatography, lectin chromatography, or high performance liquid chromatography.

It is also understood that depending upon the host cell in recombinant production of the proteins described herein, the proteins can have various glycosylation patterns, depending upon the cell, or maybe non-glycosylated as when produced in bacteria. In addition, the proteins may include an initial modified methionine in some cases as a result of a host-mediated process.

Nucleic Acid Arrays

The present invention further provides arrays or microarrays of nucleic acid molecules that are based on the sequence information provided in the Figure Sheets SEQ ID NOs: 1 , 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)).

As used herein "Arrays" or "Microarrays" refers to an array of distinct polynucleotides or oligonucleotides synthesized on a substrate, such as paper, nylon or other type of membrane, filter, chip, glass slide, or any other suitable solid support. In one embodiment, the microarray is prepared and used according to the methods described in US Patent 5,837,832, Chee et al., PCT application W095/11995 (Chee et al.), Lockhart, D. J. et al. (1996; Nat. Biotech. 14: 1675-1680) and Schena, M. et al. (1996; Proc. Natl. Acad. Sci. 93: 10614-10619), all of which are incoφorated herein in their entirety by reference. In other embodiments, such arrays are produced by the methods described by Brown et. al., US Patent No. 5,807,522.

The microarray is preferably composed of a large number of unique, single-stranded nucleic acid sequences, usually either synthetic antisense oligonucleotides or fragments of cDNAs, fixed to a solid support. The oligonucleotides are preferably about 6-60 nucleotides in length, more preferably 15-30 nucleotides in length, and most preferably about 20-25 nucleotides in length. For a certain type of microarray, it may be preferable to use oligonucleotides that are only 7-20 nucleotides in length. The microarray may contain oligonucleotides that cover the known 5', or 3', sequence, sequential oligonucleotides which cover the full length sequence; or unique oligonucleotides selected from particular areas along the length of the sequence. Polynucleotides used in the microarray may be oligonucleotides that are specific to a gene or genes of interest.

In order to produce oligonucleotides to a known sequence for a microarray, the gene(s) of interest (or an ORF identified from the contigs of the present invention) is typically examined using a computer algorithm which starts at the 5' or at the 3' end of the nucleotide sequence. Typical algorithms will then identify oligomers of defined length that are unique to the gene, have a GC content within a range suitable for hybridization, and lack predicted secondary structure that may interfere with hybridization. In certain situations it may be appropriate to use pairs of oligonucleotides on a microarray. The "pairs" will be identical, except for one nucleotide that preferably is located in the center of the sequence. The second oligonucleotide in the pair (mismatched by one) serves as a control. The number of oligonucleotide pairs may range from two to one million. The oligomers are synthesized at designated areas on a substrate using a light-directed chemical process. The substrate may be paper, nylon or other type of membrane, filter, chip, glass slide or any other suitable solid support. In another aspect, an oligonucleotide may be synthesized on the surface of the substrate by using a chemical coupling procedure and an ink jet application apparatus, as described in PCT application W095/251116 (Baldeschweiler et al.) which is incoφorated herein in its entirety by reference. In another aspect, a "gridded" array analogous to a dot (or slot) blot may be used to arrange and link cDNA fragments or oligonucleotides to the surface of a substrate using a vacuum system, thermal, UV, mechanical or chemical bonding procedures. An array, such as those described above, may be produced by hand or by using available devices (slot blot or dot blot apparatus), materials (any suitable solid support), and machines (including robotic instruments), and may contain 8, 24, 96, 384, 1536, 6144 or more oligonucleotides, or any other number between two and one million which lends itself to the efficient use of commercially available instrumentation.

In order to conduct sample analysis using a microarray, the RNA or DNA from a biological sample is made into hybridization probes. The mRNA is isolated, and cDNA is produced and used as a template to make antisense RNA (aRNA). The aRNA is amplified in the presence of fluorescent nucleotides, and labeled probes are incubated with the microarray so that the probe sequences hybridize to complementary oligonucleotides of the microarray. Incubation conditions are adjusted so that hybridization occurs with precise complementary matches or with various degrees of less complementarity. After removal of nonhybridized probes, a scanner is used to determine the levels and patterns of fluorescence. The scanned images are examined to determine degree of complementarity and the relative abundance of each oligonucleotide sequence on the microarray. The biological samples may be obtained from any bodily fluids (such as blood, urine, saliva, phlegm, gastric juices, etc.), cultured cells, biopsies, or other tissue preparations. A detection system may be used to measure the absence, presence, and amount of hybridization for all of the distinct sequences simultaneously. This data may be used for large scale correlation studies on the sequences, expression patterns, mutations, variants, or polymoφhisms among samples.

Using such arrays, the present invention provides methods to identify the expression of one or more of the proteins/peptides of the present invention. In detail, such methods comprise incubating a test sample with one or more nucleic acid molecules and assaying for binding of the nucleic acid molecule with components within the test sample. Such assays will typically involve arrays comprising many genes, at least one of which is a gene of the present invention. Conditions for incubating a nucleic acid molecule with a test sample vary. Incubation conditions depend on the format employed in the assay, the detection methods employed, and the type and nature of the nucleic acid molecule used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification or array assay formats can readily be adapted to employ the novel fragments of the Drosophila genome disclosed herein. Examples of such assays can be found in Chard, T, An Introduction to Radioimmunoassay and Related Techniques, Elsevier Science Publishers, Amsterdam, The Netherlands (1986); Bullock, G. R. et al, Techniques in Immunocytochemistry, Academic Press, Orlando, FL Vol. 1 (1 982), Vol. 2 (1983), Vol. 3 (1985); Tijssen, P., Practice and Theory of Enzyme Immunoassays: Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier Science Publishers, Amsterdam, The Netherlands (1985).

The test samples of the present invention include cells, protein or membrane extracts of cells. The test sample used in the above-described method will vary based on the assay format, nature of the detection method and the tissues, cells or extracts used as the sample to be assayed. Methods for preparing nucleic acid extracts or of cells are well known in the art and can be readily be adapted in order to obtain a sample that is compatible with the system utilized.

In another embodiment of the present invention, kits are provided which contain the necessary reagents to carry out the assays of the present invention.

Specifically, the invention provides a compartmentalized kit to receive, in close confinement, one or more containers which comprises: (a) a first container comprising one of the nucleic acid molecules that can bind to a fragment of the Drosophila genome disclosed herein; and (b) one or more other containers comprising one or more of the following: wash reagents, reagents capable of detecting presence of a bound nucleic acid. Preferred kits will include chips that are capable of detecting the expression of 10 or more, or 50 or more, or all of the GPCR genes expressed in Drosophila. In detail, a compartmentalized kit includes any kit in which reagents are contained in separate containers. Such containers include small glass containers, plastic containers, strips of plastic, glass or paper, or arraying material such as silica. Such containers allows one to efficiently transfer reagents from one compartment to another compartment such that the samples and reagents are not cross-contaminated, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another. Such containers will include a container which will accept the test sample, a container which contains the nucleic acid probe, containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and containers which contain the reagents used to detect the bound probe. One skilled in the art will readily recognize that the previously unidentified GPCR genes of the present invention can be routinely identified using the sequence information disclosed herein can be readily incoφorated into one of the established kit formats which are well known in the art, particularly expression arrays.

Uses of vectors and host cells

The recombinant host cells expressing the proteins described herein have a variety of uses. First, the cells are useful for producing a GPCR protein or protein that can be further purified to produce desired amounts of GPCR protein or fragments. Thus, host cells containing expression vectors are useful for protein production. Host cells are also useful for conducting cell-based assays involving the GPCR protein or

GPCR protein fragments, such as those described above as well as other formats known in the art. Thus, a recombinant host cell expressing a native GPCR protein is useful for assaying compounds that stimulate or inhibit GPCR protein function.

Host cells are also useful for identifying GPCR protein mutants in which these functions are affected. If the mutants naturally occur and give rise to a pathology, host cells containing the mutations are useful to assay compounds that have a desired effect on the mutant GPCR protein (for example, stimulating or inhibiting function) which may not be indicated by their effect on the native GPCR protein.

Genetically engineered host cells can be further used to produce non-human transgenic animals. A transgenic animal is preferably a mammal, for example a rodent, such as a rat or mouse, in which one or more of the cells of the animal include a transgene. A transgene is exogenous DNA which is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal in one or more cell types or tissues of the transgenic animal. These animals are useful for studying the function of a GPCR protein and identifying and evaluating modulators of GPCR protein activity. Other examples of transgenic animals include non-human primates, sheep, dogs, cows, goats, chickens, and amphibians.

A transgenic animal can be produced by introducing nucleic acid into the male pronuclei of a fertilized oocyte, e.g., by microinj ection, retroviral infection, and allowing the oocyte to develop in a pseudopregnant female foster animal. Any of the GPCR protein nucleotide sequences can be introduced as a transgene into the genome of a non-human animal, such as a mouse.

Any of the regulatory or other sequences useful in expression vectors can form part of the transgenic sequence. This includes intronic sequences and polyadenylation signals, if not already included. A tissue-specific regulatory sequence(s) can be operably linked to the transgene to direct expression of the GPCR protein to particular cells.

Methods for generating transgenic animals via embryo manipulation and microinj ection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Patent Nos. 4,736,866 and 4,870,009, both by Leder et al, U.S. Patent No. 4,873,191 by Wagner et al and in Hogan, B., Manipulating the Mouse Embryo, (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1986). Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the transgene in its genome and or expression of transgenic mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene can further be bred to other transgenic animals carrying other transgenes. A transgenic animal also includes animals in which the entire animal or tissues in the animal have been produced using the homologously recombinant host cells described herein.

In another embodiment, transgenic non-human animals can be produced which contain selected systems which allow for regulated expression of the transgene. One example of such a system is the cre/loxP recombinase system of bacteriophage PI . For a description of the cre/loxP recombinase system, see, e.g., Lakso et al. PNAS 89:6232-6236 (1992). Another example of a recombinase system is the FLP recombinase system of S. cerevisiae (O'Gorman et al. Science 257:1351-1355 (1991). If a cre/loxP recombinase system is used to regulate expression of the transgene, animals containing transgenes encoding both the Cre recombinase and a selected protein is required. Such animals can be provided through the construction of "double" transgenic animals, e.g., by mating two transgenic animals, one containing a transgene encoding a selected protein and the other containing a transgene encoding a recombinase. Clones of the non-human transgenic animals described herein can also be produced according to the methods described in Wilmut, I. et al. Nature 355:810-813 (1997) and PCT International Publication Nos. WO 97/07668 and WO 97/07669. In brief, a cell, e.g., a somatic cell, from the transgenic animal can be isolated and induced to exit the growth cycle and enter G₀ phase. The quiescent cell can then be fused, e.g., through the use of electrical pulses, to an enucleated oocyte from an animal of the same species from which the quiescent cell is isolated. The reconstructed oocyte is then cultured such that it develops to morula or blastocyst and then transferred to pseudopregnant female foster animal. The offspring born of this female foster animal will be a clone of the animal from which the cell, e.g., the somatic cell, is isolated. Transgenic animals containing recombinant cells that express the proteins described herein are useful to conduct the assays described herein in an in vivo context. Accordingly, the various physiological factors that are present in vivo and that could effect ligand binding, GPCR protein activation, and signal transduction, may not be evident from in vitro cell-free or cell-based assays. Accordingly, it is useful to provide non-human transgenic animals to assay in vivo GPCR protein function, including ligand interaction, the effect of specific mutant GPCR proteins on GPCR protein function and ligand interaction, and the effect of chimeric GPCR proteins. It is also possible to assess the effect of null mutations, that is mutations that substantially or completely eliminate one or more GPCR protein functions.

All publications and patents mentioned in the above specification are herein incoφorated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific prefened embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above- described modes for carrying out the invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims.

Table 1

Gene Transcript F W V Gene Transcript F W V

Similar to E Value Similar to E Value

A. Rhodopsin-like receptor family Orphan receptors Opsin-like Related to C elegan orphan receptors

CG5638 Cl 17820 Rh3 e-57 e-14 e-44 CG2 I I 4 CT2366 >e-10 e-27 e- 10

CG3171 C l 10621 EG 22C5 10 e-50 e-16 e-26

Receptors for biogenic amines and related compounds CG5936 CT18637 >e-10 e-18 >e-10 5-HT receptor-like CG8985 CT25824 CG 13803 e-162 e-31 >e-10

CG8007 CT24060 5-1 IT2 e-21 e-35 e-27 CG13803 C T33298 CG8985 e-162 e-36 >e-IO

CG 13229 CT32473 CG I 3803 e-58 e-35 e-10

Muscarinic Acetylcholine receptor-like

CG7918 CT23924 mAcR-60C e-32 e-49 e-41 Other orphan receptors

CG9569 CT17758 >e-10 >e-10 >e-I0

Unclassifiable biogenic amine receptor- like CG 12290 CT 19320 >e-10 >e-10 >e-10

CG 17004 CT37739 5-HT7 e-18 e-20 e-28 CG6986 CT21642 CG 16726 e-10 >e-10 >e-I O

CG7431 CT22855 CGI 6766 e-70 e-45 e-37 CG 13579 CT32961 >e-IO e-18 >e-I O

CGI 6766 CT37292 CG7431 e-53 e-31 e-22 CGI 3995 CT33551 >e-10 e-13 e-l I

CGI 2796 CT38338 CG6919 e-23 e-20 e-30 CG7497 CT23019 >e-10 >e-10 >e-10

CG6919 CT21432 CG6989 e-82 e-46 e-57

CG6989 CT21650 CG6919 e-82 e-39 e-46

CG7078 CT2 I 843 CG6919 e-73 e-46 e-38 Calcitoniπ receptor-like

CG 18314 CT4I 076 CG6919 e-21 e-48 e-25 CG4395 CT4 I 2 I CG I 7415 e-46 e-16 e-41

CG7994 CT24036 >e-10 >e-10 e-10 CG17415 CT38445 CG4395 e-42 e-20 e-61

CGI 3758 CT33238 CG8422 e-40# e-65 e-66

Purine receptors

Adenosine receptor-like B. S« Diuretic hormone receptor-like

CG9753 CT27563 CG6989 e-19 e-29 e-42 CG8422 CT24513 CG 12370 e-122 e-25 e-65

CGI 2370 CT24959 CG8422 e-122 e-30 e-101

Peptide receptors

Allatostatin receptor-like HE6 receptor-like

CG I 0001 CT28187 EG 121 E7 2 e-62 e-35 e-34 CG1 1318 CT31591 CGI 5556 e-l 04 e-l l e-20

CGI 5556 CT35672 CG I I 318 e-l 03 >e-l l e-6

FSH/TSH/ H receptor-like

CG4187 CT 13764 CG5042 e-48 e-23 e-24 Latrophilin-Iike

CG5042 CT16185 CG4187 e-44 e-25 e-23 CG8639 CT8755 >e-10 e-47 e-45

Gastrin/CCK receptor-like Methuselah-like

CG6857 C I 21 155 CG6881 e-96 e-33 e-19 CG4521 CT14539 CG6965 e-30 e-13

CG6881 CT21314 CG6857 e-96 e-23 e-33 CGI 7795 CT 16507 mth e-l 32 >e-10 >e-10

CG6530 CT20339 CG6536 e-l 04 >e-IO >e-10

Conadotropin releasing hormone receptor-like CG6536 CT2035I CG6530 e-l 15 >e-IO

CG 10698 CT29989 GRHR e-43 e-34 e-39 CG6965 CT2 I 585 CG I 7795 e-12 >e-IO e-10

CG7476 CT22963 mth e-66 >e-10 >e-10

Growth hormone secretagoge receptor-like CGI 3406 CT32762 CG I 7084 e-47 >e-10 >e-10

CG8784 CT25324 CG8795 e-165 e-38 e-35 CGI 7084 CT33414 CG I 3406 e-47 >e-IO >e-10

CG8795 CT25350 CG8784 e-165 e-40 e-37 CGI 7061 CT33415 mth e-80 >e-IO >e-10

CG9918 CT27924 CG8795 e-83 e-53 e-33 CGI 6992 CT377I 5 mth e-32 >e-IO >e-10

Tachykiπin receptor-like C. Metabotropic glutamate receptor family

CGI 147 CT1960 NepYr e-31 e-43 e-40 GABA-B receptor-like

CG I 0626 CT29768 Takr99D e-53 e-41 e-44 CG3022 CT9836 CG6706 e-96 e-56 e-85

CG6706 CT20836 CG3022 e-120 e-61 e-169

Somatostatin receptor-like CG15274 CT35221 CG3022 e-49 e-156 e-129

CG7285 CT22465 CGI 3702 e-96 e-24 e-51

CG I 3702 CT33159 CG7285 e-96 e-26 e-46 Metabotropic glutamate receptor-like

CG8692 CT5032 Glu-RA e-152 e-l 15 e-157

Vasopressin receptor-like

CG61 1 1 CT19191 GRHR e-36 e-26 e-45 Other

CG7I 55 CT221 I7 >e-I O >e-IO >e-10

Unclassifiable peptide receptors CGI 1923 CT35779 CG 17215 e-17 >e-10 e-17

CG I 3575 CT32957 CGI 0626 e-08 e-08 e-8#

CG 14003 CT33559 Takr99D e-14 e-12 e-14# '. Atypical 7 TM proteins

CG591 1 CT 18539 Takr86C e-18 e-19 e-26# Frizzled-like

CG10823 CT18916 CG6857 e-10 e-10 e-12 CG4626 C I^"9057 fz e-36 e-54 e-76

Claims

ClaimsThat which is claimed is:

1. An isolated protein consisting of an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198;

(b) the amino acid sequence of an allelic variant of the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said allelic variant is encoded by a nucleic acid molecule that hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1, 4, 7, . . . , 795, 798, 801 (genomic sequences); SEQ ID NOs: 2, 5, 8, . . . , 796, 799, 802 (transcript sequences), under stringent conditions;

(c) the amino acid sequence of an orfholog of an amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said ortholog is encoded by a nucleic acid molecule that hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1, 4, 7, . . . , 795, 798, 801 (genomic sequences); SEQ ID NOs: 2, 5, 8, . . . , 796, 799, 802 (transcript sequences), under stringent condition;

(d) a fragment of the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein the fragment comprises at least 10 contiguous amino acids.

2. An isolated protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198;

(b) the amino acid sequence of an allelic variant of the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said allelic variant is encoded by a nucleic acid molecule that hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1, 4, 7, . . . , 795, 798, 801 (genomic sequences); SEQ ID NOs: 2, 5, 8, . . . , 796, 799, 802 (transcript sequences), under stringent conditions;

(c) the amino acid sequence of an ortholog of an amino acid sequence shown in the SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said ortholog is encoded by a nucleic acid molecule that hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1 , 4, 7, . . . , 795, 798, 801 (genomic sequences); SEQ ID NOs: 2, 5, 8, . . . , 796, 799, 802 (transcript sequences), under stringent condition; (d) a fragment of the amino acid sequence shown in the SEQ ID NOs: 3, 6, 9, . . . , 192. 195, 198, wherein the fragment comprises at least 10 contiguous amino acids.

3. An isolated antibody that selectively binds to a protein of claim 1.

4. An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:

(a) a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198;

(b) a nucleotide sequence that encodes of an allelic variant of the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said nucleic acid molecule hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)), under stringent conditions;

(c) a nucleotide sequence that encodes an ortholog of an amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said nucleic acid molecule hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)), under stringent condition;

(d) a nucleotide sequence that encodes a fragment of the amino acid sequence shown in the SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said the fragment comprises at least 10 contiguous amino acids; and

(e) A nucleic acid molecule that is the complement of a nucleic acid molecule of(a)-(d).

5. An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

(a) a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198;

(b) a nucleotide sequence that encodes of an allelic variant of the amino acid sequence shown in SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said nucleic acid molecule hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1, 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)), under stringent conditions;

(c) a nucleotide sequence that encodes an ortholog of an amino acid sequence shown in the SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said nucleic acid molecule hybridizes to the nucleic acid molecule shown in SEQ ID NOs: 1 , 4, 7, . . . , 190, 193, 196 (genomic sequences) or SEQ ID NOs: 2, 5, 8, . . . , 191, 194, 197 (transcript sequences)), under stringent condition;

(d) a nucleotide sequence that encodes a fragment of the amino acid sequence shown in the SEQ ID NOs: 3, 6, 9, . . . , 192, 195, 198, wherein said the fragment comprises at least 10 contiguous amino acids; and

(f) A nucleic acid molecule that is the complement of a nucleic acid molecule of (a)-(d)_.

6. A nucleic acid vector comprising the nucleic acid sequences of claim 4.

7. A nucleic acid vector comprising the nucleic acid sequences of claim 5.

8. A host cell containing the vector of claim 6.

9. A host cell containing the vector of claim 7.

10. A method for producing any of the proteins of claim 1 comprising introducing a nucleotide sequence encoding any of the protein sequences in (a)-(d) into a host cell, and culturing the host cell under conditions in which the proteins are expressed from the nucleic acid.

11. A method for producing any of the proteins of claim 2 comprising introducing a nucleotide sequence encoding any of the protein sequences in (a)-(d) into a host cell, and culturing the host cell under conditions in which the proteins are expressed from the nucleic acid.

12. A method for detecting the presence of any of the proteins of claim 1 in a sample, said method comprising contacting said sample with an agent that specifically allows detection of the presence of the protein in the sample and then detecting the presence of the protein.

13. A method for detecting the presence of any of the proteins of claim 2 in a sample, said method comprising contacting said sample with an agent that specifically allows detection of the presence of the protein in the sample and then detecting the presence of the protein.

14. A kit comprising reagents used for the method of claim 12, wherein the reagents comprise an agent that specifically binds to said protein.

15. A method for detecting the presence of a nucleic acid sequence of claim 4 in a sample, the method comprising contacting the sample with an oligonucleotide that hybridizes to the nucleic acid sequences under stringent conditions and determining whether the oligonucleotide binds to the nucleic acid sequence in the sample.

16. A method for detecting the presence of a nucleic acid sequence of claim 5 in a sample, the method comprising contacting the sample with an oligonucleotide that hybridizes to the nucleic acid sequences under stringent conditions and determining whether the oligonucleotide binds to the nucleic acid sequence in the sample.

17. A kit comprising reagents used for the method of claim 15, wherein the reagents comprise a compound that hybridizes under stringent conditions to any of the nucleic acid molecules.

18. A kit comprising reagents used for the method of claim 16, wherein the reagents comprise a compound that hybridizes under stringent conditions to any of the nucleic acid molecules.

19. A method for identifying an agent that binds to any of the proteins of claim 1 , said method comprising contacting the protein with an agent and assaying the contacted mixture to determine whether a complex is formed with the agent bound to the protein.

20. A method for identifying an agent that binds to any of the proteins of claim 2, said method comprising contacting the protein with an agent and assaying the contacted mixture to determine whether a complex is formed with the agent bound to the protein. SEQUENCE LISTING

<110> CravσmyE÷. Anibal

<120> ISOLATED G-PROTEIN COUPLED RECEPTORS,

NUCLEIC ACID MOLECULES ENCODING GPCR PROTEINS, AND USES THEREOF AS INSECTICIDAL TARGETS

<130> CL000733PCT

<150> 60/191,638 <151> 2000-03-23

<160> 198

<170> FastSEQ for Windows Version 4 . 0

<210> 1

<211> 5236

<212> DNA

<213> Drosophila

<400> 1 caaaaactaa aacaacaaaa agccggcaag caatggtata caaaataaat aaaaaaaaat 60 atgacaagag aaaatccaca aaaaaatgaa ataaaattga atgaaaaatt taccaaaaac 120 caagttgttt ttattccaag tgtatgtagt tggcaatcaa acgattcaac tgcagttaac 180 atgatttatt cgctacgtaa gtgtgcttgg ctaagttgaa taaatatcat taatatctgt 240 cagctacatt aaaggttcaa acattacata tatatatatc tatatattta tcttaacatt 300 attaaatgtt taagggctta aaaaaaaata tccttaggta cacgggtacg tatgtattat 360 tctgcgtctc tttctatatc ctctcaggat ttgaatatat tttgtattat aaaatattac 420 gcataaaatc atcgggggga acctgttaat tcttggcatt tgattcccgc attttctctg 480 gatatggcat agatattttt ctagggttag ctgtgtgaaa cctaaatatt tttaagttaa 540 atttaaacaa cgatttatac ggctgacaca ttttaaattt ttctgggttc aagcttagat 600 tttgtttaca tgtttttttc ttaatgctta acactatgct ttatatactt tttcaaaata 660 tattttaaaa cttgttcagt aaaaagtttt aaagtgataa ttcttaacag agttttttta 720 gaaacttttt ttttagaaag atcaagcata caattatttg tttttatcaa taattcatat 780 gactagaacc tttcttttct aaatgcattt cgggcatagt atcccaggat aaaaaatata 840 acaggaacat tttaaataat tgaaatcagt atgcatttta acaaaattaa gttataaaaa 900 aaaatatttt gctatcatga aataagtgtg ccggactggt cttcaaaatc tttgctcggc 960 gatgcggtca atgttacgat cgaccctcgc gcggtacgcc ttaaacgccc aactctcggc 1020 tgggcgtggt cgtggccatc tgtccagtat tactcccggc cggcggcggg gtcactaaac 1080 tgggcagcaa cttgttcagc agcgtgcgaa tggcaaaggt gacatcgtga ttggcgaagc 1140 agaacaggaa ggagaccaca aagccctgca ggctgaccaa caccaccgat agcatctgat 1200 agaagtggtc cagctgggtg ccggcatccg gacggtaggg cagcaggaag tgttgcagtc 1260 cgaacagcgg taccagaata atggtggccc gaaccgcctt ccggatggcc aacggtgccg 1320 gctgggcgga ctggggatgt aactttcgca cgatcactcg cagtacgttg atcagaaaaa 1380 ctgttgggta aaatgcatat agctgagcaa tattgtactt ttaaagaaaa ttatgcatat 1440 tactaaagct ggccagcagc gaaagagtta tgggcaccga gaagatccac aagtagagac 1500 tgtcagttat ccagcagctg caataatgtg aaaagaaatg ttaccatgga tatagcgtag 1560 aatgtaatct cttaataaat gcaatgcaaa aaccaaatca atcaggatta tgtcttgtgt 1620 aaaattgtga aaataactta ctgcttattg tccggactac tgaaatgcct ggccagaccg 1680 tagacgatgg ctatgggtat gggtgaaaac cagctgatga caataaacca gcgcatcaca 1740 atcgtgtcct tgacaaagac ctggcgaatg gaaagaagaa ggggcgtcag gatctgaacg 1800 gacattcctg acatctcaac ttgacgcaga cgtaaagcag ttggccaacg ttgcgatttg 1860 ctctcagaca aattgctggg ggtgaaccat tgccatgtca gcggctgcag gaaatcacat 1920 ctgccatgca cagaagtcgc ccataaagaa tgcagacttg tgcaggcaat tgccagattg 1980 ccagacgagt aaggataact caccacaacg agcaccaggt gcaggtgcag gccctcgcaa 2040 aacatccaga aatagttgac caacataaag tagtgcacca ccagatgcag cccaatgcac 2100 cacagctgaa agttagttat gtttatggtt ttgtataatt gcctagctac ttgtagggct 2160 atgttatttt catagttact tttctcagtg catcttaccg gattttcggc tatggtttcg 2220 gaacgctcca ccaccagacg ataccataat atccaggcca cacaggtgca ggccagcgag 2280 gcgaacagat gtacatggat gcggatgcgg gtgcagcgca gggatctgca aacggaatgg 2340 aacggaacgg aaagaaacga aaagggatat ccggccgtca gttaccggag ggaaaggaac 2400 cgtgtgggtc gtagacaaac acttacttga agcccaagaa aataataatc gatatgagca 2460 gggccagcag ggagagggca taacccttca cgtacagctc gttgatgaac tggcgaaact 2520 gcagtggcaa ctttcttgat taatgcccat gtaccacccg cttgatgccg ccgaagcact 2580 tacctccagg tcctcatagt ccacgcagtt ggtgtaattg gaccaggtct gattgctaac 2640 cggatgacgg taccaggagc cgttctccag gcagctatga atgcgaaatg cttacgataa 2700 ttgtgactgg ctaagtgcgg actgatgggt aaagggggta tttctaacaa agcgcctgac 2760 aatgcacaag ttacccaact ttaccaggag ccagctgagc tcagttggcg tgtaaagtga 2820 gatgaacgct atccattaaa ttggagatac atacatgtag tgcaagtttt agagtgctgc 2880 tacagtacac ttagggagat tatctctgca agagttgaag aaggttttat ttttctttca 2940 ttttccatca tctttttctg agatatgctg cgagtttatg taatagacac gaatgtaaac 3000 tctataggat tttccctgtt tgtagcgcac tcatacataa acattgtatt ttatgacaca 3060 cagaacacat taaagcaaat gccgaatatg gcaagatatt ttcgaattta tgctcaaacg 3120 aatattacat attgcagagc ttatttgacc atgcgaaatc ctgaacggaa tgaaaatcta 3180 tcctattcgt ggtggcgtaa tatacaggca tattgggcat ttaactcacg tcttgtgggc 3240 cagaaatttt ctgttgaatc cttcgacgaa atcgggacaa tattgactca gcacagtgcc 3300 ggccggagtc cttggccagc agagatatcc gtcaaagttc agggggcaaa agagtcggtt 3360 ctccttctga tttgtggcca tcgtggcact gacgacggtg gccatcagct cctccttctc 3420 cgccagctcc tcgtccacgt ttcgcatgtc aataacgccc tcgttcatcg cggcattctc 3480 cagatatcgc ggcactgggc taaagttctc cggcaaatcg gaatcgtagt ctgtgcacgg 3540 cgacaagtgc cattaaaatg ggtttacttt ttaatgtata aaaatatagc atttttaata 3600 atagtatcta tgggctgcat aactgaaagt gatgtaattc agttttcaag ttcaattcaa 3660 ttgcatgctt gctttacata tgtaaaataa agtggtattt caaatgtaca taacttgctt 3720 aagatagtta atagatcatc gttctttata gcagggtata attcataaat tctggttgaa 3780 aatatatgta catttggtaa aggtgttgag tgctatttaa atttataaat ttgtcctgag 3840 atgccaatga tttgcattga aacgaaaacc catgtttaaa tttgcatccc caagaagtaa 3900 gtcaatgatt ttgtatatat ttaaatacat tactttgaaa tgcattaaat gaaatcagat 3960 gggctgtaat ttaatttaat tctcttctct ttcttatctg tcttatgcct ctgctatttt 4020 ttcgcggcaa atcacgtata cgcctgttgg ccgccactca cctgttgctg ggccaagtga 4080 aaatgatggg tcgtccgtat cgtatgtgac attctggtat cggaacacgc actccgcata 4140 caaatgcttt aaaaatatgc gcagattatc ctgcgtttgg gcctgcgatg ccacatccac 4200 attttgcgac tccgaatctg aagaggttgt cgccattgtg ggttattcaa cgtgactaac 4260 tcttgtcaac ggctaatgca ctaaaaaaaa atataataat ataaatataa ttcaaagaat 4320 tacgggataa ataggataat caactgcaat aatttatcag aggcaatttg aaaggtttta 4380 aacaagtgtt gcttacccat agaaacttgt atgagctagt ttttaaaatt tattctgatt 4440 taaatatatt ttcttatatt taacattagt tctcactgta tttcgccata gcgaagcgaa 4500 cttgagtccc ttgtggccgt ccattcgtgt gtgcatttct aatttggtta ggcttcaaag 4560 agttgcctga gttgggttga tatttgttgt ggggtcctgt ctgcggggaa atggtgccaa 4620 aggaaatgga atatccacac ggggcacaca cacacactca aaatatcgaa gcacctgagt 4680 gtcgtgtgag ccgagtcacc tactcgtctc tcatatgttg taaatcagtt tattgtctaa 4740 ttaatggcgg tgcttaactg tgtcgctatt tctgctaccg tggttgggcg aacttaattg 4800 catttcgtcg cacagagaga caaagcaaat gccacgggtt aaaaactcaa atgaaatgca 4860 ctttgatcgt gggggcacac aaacacacaa acacataaac acactcacac acccgcaccg 4920 aacacgtggc ccaaaaggcg ggatgagctg caaagttctt gcctaacttg gttatatttt 4980 taatcaaaac tcatttcact tgattgagtt tcgacagaag cctgcaccag gcactggaaa 5040 atctagcatg cacgatacat acaaagtaag atgattttcc cgctcccaag ctaaacttta 5100 atttgcggca ttaatttatt acaccgaact gggacagttt cccatgatgg atatgacgcc 5160 tggctaaaca ttcttgcatg ttatatatat ttttgcaagt gtctcggcca ggcaattagc 5220 cgcaggtaag cggagc 5236

<210> 2

<211> 1686

<212> DNA

<213> Drosophila <400> 2 atggcgacaa cctcttcaga ttcggagtcg caaaatgtgg atgtggcatc gcaggcccaa 60 acgcaggata atctgcgcat atttttaaag catttgtatg cggagtgcgt gttccgatac 120 cagaatgtca catacgatac ggacgaccca tcattttcac ttggcccagc aacagactac 180 gattccgatt tgccggagaa ctttagccca gtgccgcgat atctggagaa tgccgcgatg 240 aacgagggcg ttattgacat gcgaaacgtg gacgaggagc tggcggagaa ggaggagctg 300 atggccaccg tcgtcagtgc cacgatggcc acaaatcaga aggagaaccg actcttttgc 360 cccctgaact ttgacggata tctctgctgg ccaaggactc cggccggcac tgtgctgagt 420 caatattgtc ccgatttcgt cgaaggattc aacagaaaat ttctggccca caagacctgc 480 ctggagaacg gctcctggta ccgtcatccg gttagcaatc agacctggtc caattacacc 540 aactgcgtgg actatgagga cctggagttt cgccagttca tcaacgagct gtacgtgaag 600 ggttatgccc tctccctgct ggccctgctc atatcgatta ttattttctt gggcttcaaa 660 tccctgcgct gcacccgcat ccgcatccat gtacatctgt tcgcctcgct ggcctgcacc 720 tgtgtggcct ggatattatg gtatcgtctg gtggtggagc gttccgaaac catagccgaa 780 aatccggtaa gatgcactga gaaaagtaac tatgaaaata acatagccct acaagtagct 840 aggcaattat acaaaaccat aaacataact aactttcagc tgtggtgcat tgggctgcat 900 ctggtggtgc actactttat gttggtcaac tatttctgga tgttttgcga gggcctgcac 960 ctgcacctgg tgctcgttgt ggtgagttat ccttactcgt ctggcaatct ggcaattgcc 1020 tgcacaagtc tgcattcttt atgggcgact tctgtgcatg gcagatgtga tttcctgcag 1080 ccgctgacat ggcaatggtt cacccccagc aatttgtctg agagcaaatc gcaacgttgg 1140 ccaactgctt tacgtctgcg tcaagttgag atgtcaggaa tgtccgttca gatcctgacg 1200 ccccttcttc tttccattcg ccaggtcttt gtcaaggaca cgattgtgat gcgctggttt 1260 attgtcatca gctggttttc acccataccc atagccatcg tctacgtttt tctgatcaac 1320 gtactgcgag tgatcgtgcg aaagttacat ccccagtccg cccagccggc accgttggcc 1380 atccggaagg cggttcgggc caccattatt ctggtaccgc tgttcggact gcaacacttc 1440 ctgctgccct accgtccgga tgccggcacc cagctggacc acttctatca gatgctatcg 1500 gtggtgttgg tcagcctgca gggctttgtg gtctccttcc tgttctgctt cgccaatcac 1560 gatgtcacct ttgccattcg cacgctgctg aacaagttgc tgcccagttt agtgaccccg 1620 ccgccggccg ggagtaatac tggacagatg gccacgacca cgcccagccg agagttgggc 1680 gtttaa 1686

<210> 3 <211> 561 <212> PRT <213> Drosophila

<400> 3

Met Ala Thr Thr Ser Ser Asp Ser Glu Ser Gin Asn Val Asp Val Ala

1 5 10 15

Ser Gin Ala Gin Thr Gin Asp Asn Leu Arg lie Phe Leu Lys His Leu

20 25 30

Tyr Ala Glu Cys Val Phe Arg Tyr Gin Asn Val Thr Tyr Asp Thr Asp

35 40 45

Asp Pro Ser Phe Ser Leu Gly Pro Ala Thr Asp Tyr Asp Ser Asp Leu

50 55 60

Pro Glu Asn Phe Ser Pro Val Pro Arg Tyr Leu Glu Asn Ala Ala Met 65 70 75 80

Asn Glu Gly Val lie Asp Met Arg Asn Val Asp Glu Glu Leu Ala Glu

85 90 95

Lys Glu Glu Leu Met Ala Thr Val Val Ser Ala Thr Met Ala Thr Asn

100 105 110

Gin Lys Glu Asn Arg Leu Phe Cys Pro Leu Asn Phe Asp Gly Tyr Leu

115 120 125

Cys Trp Pro Arg Thr Pro Ala Gly Thr Val Leu Ser Gin Tyr Cys Pro

130 135 140

Asp Phe Val Glu Gly Phe Asn Arg Lys Phe Leu Ala His Lys Thr Cys 145 150 155 160

Leu Glu Asn Gly Ser Trp Tyr Arg His Pro Val Ser Asn Gin Thr Trp

165 170 175

Ser Asn Tyr Thr Asn Cys Val Asp Tyr Glu Asp Leu Glu Phe Arg Gin 180 185 190

Phe lie Asn Glu Leu Tyr Val Lys Gly Tyr Ala Leu Ser Leu Leu Ala

195 200 205

Leu Leu lie Ser lie lie lie Phe Leu Gly Phe Lys Ser Leu Arg Cys

210 215 220

Thr Arg lie Arg He His Val His Leu Phe Ala Ser Leu Ala Cys Thr 225 230 235 240

Cys Val Ala Trp He Leu Trp Tyr Arg Leu Val Val Glu Arg Ser Glu

245 250 255

Thr He Ala Glu Asn Pro Val Arg Cys Thr Glu Lys Ser Asn Tyr Glu

260 265 270

Asn Asn He Ala Leu Gin Val Ala Arg Gin Leu Tyr Lys Thr He Asn

275 280 285

He Thr Asn Phe Gin Leu Trp Cys He Gly Leu His Leu Val Val His

290 295 300

Tyr Phe Met Leu Val Asn Tyr Phe Trp Met Phe Cys Glu Gly Leu His 305 310 315 320

Leu His Leu Val Leu Val Val Val Ser Tyr Pro Tyr Ser Ser Gly Asn

325 330 335

Leu Ala He Ala Cys Thr Ser Leu His Ser Leu Trp Ala Thr Ser Val

340 345 350

His Gly Arg Cys Asp Phe Leu Gin Pro Leu Thr Trp Gin Trp Phe Thr

355 360 365

Pro Ser Asn Leu Ser Glu Ser Lys Ser Gin Arg Trp Pro Thr Ala Leu

370 375 380

Arg Leu Arg Gin Val Glu Met Ser Gly Met Ser Val Gin He Leu Thr 385 390 395 400

Pro Leu Leu Leu Ser He Arg Gin Val Phe Val Lys Asp Thr He Val

405 410 415

Met Arg Trp Phe He Val He Ser Trp Phe Ser Pro He Pro He Ala

420 425 430

He Val Tyr Val Phe Leu He Asn Val Leu Arg Val He Val Arg Lys

435 440 445

Leu His Pro Gin Ser Ala Gin Pro Ala Pro Leu Ala He Arg Lys Ala

450 455 460

Val Arg Ala Thr He He Leu Val Pro Leu Phe Gly Leu Gin His Phe 465 470 475 480

Leu Leu Pro Tyr Arg Pro Asp Ala Gly Thr Gin Leu Asp His Phe Tyr

485 490 495

Gin Met Leu Ser Val Val Leu Val Ser Leu Gin Gly Phe Val Val Ser

500 505 510

Phe Leu Phe Cys Phe Ala Asn His Asp Val Thr Phe Ala He Arg Thr

515 520 525

Leu Leu Asn Lys Leu Leu Pro Ser Leu Val Thr Pro Pro Pro Ala Gly

530 535 540

Ser Asn Thr Gly Gin Met Ala Thr Thr Thr Pro Ser Arg Glu Leu Gly 545 550 555 560

Val

<210> 4 <211> 15572 <212> DNA <213> Drosophila

<400> 4 gccgtaaact atggcgatgc cccactgtgc ccgcacacaa attccgccac ctcgctccga 60 aatcgtgtgt atttggttaa taataatcta gttgggcatc gattgttcgg ccaaaatgaa 120 gccactatcc gtggcggagt gttaattaat ttgcacttaa gcgcagctgc tggaagcact 180 tgatagaagt gggcatgccg gttctcttgg gaagttggct tactatagtt tagcgttaag 240 gcgttaactt gtggccttta aagttcttag agaagacttt ctgcagctgc tcaggctgtt 300 cattgcggca tctagcataa aatttagagt ttgaaagtaa gtttctatga aaaaaaaata 360 cacgtatata taagtataac aagaaaagga ccaaatcaaa gtttatatac cattgctgta 420 cttatatatt tgaatattaa atatacacaa ataaatatat accgaataag aacactttat 480 gattaaaagc aacaattatt gattaatcta cttctaccta aactggtgtt gaaactggta 540 taatgaaaaa caactaaggt acatttactt ccatttaatt ttctattggc agctatataa 600 taaacagttc cgatccaacg tgaaccgacc tatcaccatt tttgataaag ttttacgcag 660 aaacgtaaaa atatctaaaa gcatgctatt ttgtatttgt atttttgtat tttgtagaga 720 aaagttgtag atctatattt aattttgcac acatgagcat tttaatcagt tttgtataca 780 ttatttcgaa ctcttcacca acagaataaa atgaaattaa aatggtccga tgtcgggggc 840 caaacaaaat aaaggcgtat tgagttgtgc catgtttcag gtggaaaaac cagctgcaat 900 ataattgctt ttgaataatg cgaatttcgg ggggaagttt cttttaccag cacaatataa 960 acaaaactgc tcaactattt ctcgatattt acattttcag ggtccatcag caacatagat 1020 gacgcggagt atcactgcaa taagacgcag gtgcgcaagg tcatctcggg ggtggtgggt 1080 gccgcctcct cggtcacatc catacaagtt gccaatttat tgcggttatt ccgaattccc 1140 caggtgagtt tccattgtgt gatcactaac tgttcgactc agtgcgtgcg aagtccaaag 1200 gtcatggcat aaaagggcag tcctttttgt ttttagttca gattttgctt tatgctcgca 1260 actacatgta tatgtgctag tttggccaac aaaagtttct cctatttcgt aattaaaatt 1320 tccaggagcc acatggtaac tgttgcaatg gcttgcaggt ctttcggttg gctttgccga 1380 ttcctaagtg tctgcacgtg ccactaaatt agtcgagtcc cgcaggccaa ctagaggaac 1440 atagtgctgc agttgccaag aagtgtacag tagggactct cagcaatcat aacaattaat 1500 gtaattattt tactatatgt tcaatttatc tttaatatac aattccaaaa tgatgattct 1560 tagctgctaa agaactgact tacatattaa tttcctacca aaaccaataa caaactggac 1620 agatcgcttc agttgagtac ttcgactatc agatacccgt cacttgcatt accgcttaaa 1680 aagcttgtat ctagcattgc tcgtatttca actgcaaacg acattgcagt tttttgggtg 1740 ttcctcatgt agtgactaga gcgtgaaaaa cgccacaaac taatatccat ttctgattca 1800 ggaaggaata taacattttc cgagtgccgg catgaatcac gtgcaggaag ttgaaggaga 1860 ttgagtgccc ggttcggctg ctccagctac gtgagctgga gccaaaagtc aacaacgcga 1920 caataactaa gtagccaact gccagatccc ttctcgatat atatatatag tatgtactca 1980 ctactacttg gatgccatta aacgcacacg aagtgccagt cgaaggagca gcagccgttc 2040 catgcaggcc cagctatcgt cccgaaagga cctcataaat cagcaataaa catttgattg 2100 catttggttt gcacgcgtgg attctgcgct ggcttcgcat aaacagcact ttcgagcaaa 2160 ttttgtgtgt tctgcaattc aaatttctgg tcgatagcga cttagtgagt ttcgtttagg 2220 cttagcggaa attggctgca atgcaaaatg ttcgcaagga cacaattcaa atgacaatgc 2280 agttaaaaat tccgtaaatg caatatttta tggcttatcg tatttggata acaatgtttt 2340 aaatgcttga acaaagcatt gctgtctttt ttgtttaaag taaaattttt gccgtcagaa 2400 gtttgtgcat tgaattaaat ggttattcaa acattacatt ttatttatct tgaaaaaagt 2460 acaaaaatat gtattaaact cgtagtatta tatataaatt aaatatattt tattattttt 2520 tgtttttatg gactgagtaa tagcacttga attttccaac tagtttttca caatttttcg 2580 tactttaata aaagtaaata tttgcatctc tagtgtcaat tatcaaaagt caacaaagcc 2640 aaagctacac aataattttg ctataactcg acgctttaaa cgctcatgaa aatcaaaagt 2700 aattctgatt aaataaaagt gagaatgcca taaaccatag gtaaattaga ctcagaaata 2760 aggtctggta tgagttgcaa tgcctgtctt gccatgagca tttgacaagt aatcaagcac 2820 ttacgcagaa gctgttgact aatggtaatg acacttaatt agaagccaag tagttcatta 2880 aacacttgca gttgacttgc cacgccatcg acgatttgcc ccaggatgca cctacttcct 2940 gccccaagtg tttgtgggcg gatccttctc taaccaaacg gtttatgtgt gcgtgaaatt 3000 ggtttcccgg cttgggccag gtcaccacag ttggcctttt gctgcagttg ccacagcttt 3060 gggtttcgca aggtaatgcc agctgatgtt ttcttcgaca gcagcattgt ttgtggtttt 3120 tggaaaacag cttaagcgag aaaatatgag cgaaaaactg ggaaggagct tacgaaaggt 3180 tctgcagaag cgatagccca gaacgagtgc gaaaaaatat gaaaattaaa tggcgacctt 3240 aaagtgaaag gggttcttac ataaaatatt gtagcacact tgccactttg tgccacccaa 3300 gcaatagcgt ttccaactaa aatgttatcc catcatattg taacccgcct caccacattt 3360 tttccatcca ggtgtcgtac ttctccacca gccccgagct gagcaacaaa cagcgattcg 3420 agtacttctc ccgcactatt ccctcggatc actaccaggt gaaggccatg gtggagatag 3480 tgaagcggat gggatggagc tacgtgtcga ttatctacga ggagagcaat tacggaatca 3540 aggtgagtgt ttatgtatgg aactttgatt aaaatggaag aaaggagtgc atctatggct 3600 gagaaatgga gttaaagaat gagaagctct atgttttaaa agagcttgtt aaaattcaaa 3660 tttaatgtat gttgcttcat tttactttgg atacttcttg gataaaatct attttggata 3720 accattaaac attgaaaagt caataataag taagttcaat aagtttcagc cacttaaatt 3780 tcctcttttt caaaggacta cataaatttc acctaatagg gcaaatcatt taactagtaa 3840 tccttaaacg gtggaacttt aaaataatgc caagtgccgt ttaaaagcgt tagcagcact 3900 ccattatcat atgtttatat ccttagccgc ttgcagtgta aacgatatac attttaagtg 3960 aacgccttgt atcctatcca acttgtacct gtgtaaacat tttacccatc ccaccacatg 4020 cgtttttatt gctcacccac actgcacttg ttttcaggct ttcgaggaac tggaggagct 4080 cctcgcacgc cataacattt gtattgccat caaggagaag ctggtgaagg attcgggagt 4140 ggccgaggac atcgcctacg acaatatagt gcagaagctg ctgacgaagc cgcgggctcg 4200 aggtatgtaa ctggagagtg ggaagttggg attgcagaga gggatcggag gcgatgtggc 4260 ggaggaaaag tgcatttcca accggaacag cgactgcagt ctgccagtca aaatgcaatt 4320 taaaatgaaa atgtcaaagc gaaggcgcag tgcaaatgcg aaaggaaagc ccttcgcaac 4380 gcccgcacaa tgaatgcgat ccggagtcga gaactatgct aggatttttg gctgggcgac 4440 ggaaattgcg taaattaaat gaaaatattt aaaaactccc tcgccagcgc gccgttgtgc 4500 catctgtgcc agcgggaaat taaaaagttc acgacaaaac aaacggaaaa agttatttgc 4560 aaataaattg agagatagtc gcccagaagt gggcaaactg atacgtccaa tactgtagtt 4620 gtgcaaaaaa gtgtgtattt gttatggcca aaaatgaagg tcctgtctat tgtccgtgga 4680 caaaaagcca ggagtacttg gcgtccctga ggtctgatga atgacaccac ctattcgaca 4740 tggcaagcaa ttaaaaattc cagtcagggt tggccaagtt caaatttatc ggaacgattt 4800 ttcatcctaa atgaaaacga tttttccaca tggcattgcc ccaatctgcg ccaatcatgc 4860 gattcagcag cgagataaac aaaaaataaa tgtcaatcaa tttgactttt cacattttgt 4920 gttcccctgt cgaatatcag ctgccattcg cagacgccga aaagaaatat aaattaaaaa 4980 taattaccgc ccacagcttt gcgcatatca ttagtcagtg cctcgaaagg gtgaagaata 5040 tcagggtcgt gcccgccaat aaaaagcaca cgggtcgacc aataacaatt gacttttgtc 5100 tggcaaacaa tttttgattt acataaatgc gccatcagga gtcgtaaagc agtcggtcgc 5160 ccaagaaaag ggttcctccg ccaccattat ttattgtgat ttgtgatttg acgccgctta 5220 cagggcgcta gccgcctcgc aacgattaat caatttgaca aagtattttc cctggcatca 5280 gttgtttaat tttgcatatc gagggttctt tcactgctcc tggtcctggt cgtggttctg 5340 gtgggggctc cagttgggtc cctgaaaaat gatgcccttc cggatccgta actgcggctg 5400 gtaactgccg ccaggggtga actttacgct tgttcggatc cccacacatg tcactccgga 5460 gctaaatgga atgtgggcgg ggggccgaca tgtttttcct ttttatcgcc aatgtggcaa 5520 gctgatgcga tttcagccag gacatgaccg gcccccaccc gctttagatc actttctggc 5580 ccggctttaa agtttccccc taatctgcat aaatatcctg ccgagtgggc tcttaaatta 5640 aattttatat ccctgctaag aataaccgtg gttctcgact ggtataaaca ggctactgtg 5700 tacgagaaag ccgctcaagt gcatgtctaa ggcaaagtga aaatccaagg aaaatatcct 5760 taacttcaca aaagtatcga caagttttcc cgttgtcgcc gccgcttcct ttgaataaga 5820 ttccctcctc ttacttcgag tggcggagcg gcagtggcaa atcgataccg ggacatgttg 5880 aaggggcaaa aaattatggc taagacaaag gacctcttgg gcggaccgtt aagaagtgac 5940 aactgcagct cacgtatccc atacaagttt gtccagagcg aaacaataag ggctgaaagc 6000 gttggaaaat ttggtaagca cctaaccaaa ggatagtttt agaagctcct gatttccatc 6060 cgtagaacac aagcgactta ggtgtcggct ttaccaattg gccattggga acgttgtttg 6120 cttggagttt ctaatgatat cttcacactt tttgtggact ttctgttcgc ttcttgggac 6180 caattaaaat attgttttcc ttgcaaattg aagaacaata ccttggcaga aaatctaaat 6240 atagtaaaga tacgtcgcca aatggcgaac atctgaaaaa gtggttgcat tacatcaata 6300 tatacccttc gtcatgtgta ccccttgtac cccccatacc cttgttttat agacttgttt 6360 tacgcctaac ggctatagta atccaactta atttatatag catttgcgta attaatattc 6420 aaagcgaaat aatgggctgt catttaatac tataaaaaca ctttaatccg ccctcggaaa 6480 ggagaacaca agagcagttg gcagctgcag attgttttct tttgcgcaca aaagccgctc 6540 attcactatt gattgcaatt aaaattaaat tctttcttcc tcctttcgca tccttttaat 6600 acgccgctgc ccaggggcca ttatcttcgg ttcggatcaa gaggtgcgcc aagtgatgcg 6660 ggcggtgcgc cgggcgaatg caactggttc cttctcctgg atcggatccg atggctggag 6720 tgcccggaat ttggtgtccg acgactacga gccggaggta ggtgaactat tccgtcagac 6780 cggatgacgg gccagttacc gtcagccgga aattatgagc ctaaatgggc ggaacaactc 6840 ggtttgatta atgactcgga tttcggtcac atactcacgc acgcacatac gagggcccaa 6900 ccccattaca tgataaccaa aaaattataa atgatggcgg ccgaaagaac actttcacac 6960 gccctttccc atgatgaatt atggttcaat ttggattaat cgtgcctttg tctgtgcgtg 7020 gctaattaat ttgtctaagc ccttcaagcc cagaaatggt cctcctctct gatcaagctc 7080 attaagtata cgccgcgtgt gtcttggtgt catcaacagg tggaaggcac gctgtctgtg 7140 cagccgcagg cgaatccggt gcgcgggttc gaggagtact tcctcagtct gacggtggag 7200 aacaatcaac gcaatccctg gtttgtgggt aagtgaatta ccgattaaaa ttaagctggt 7260 gttcattaat gctctgatat aagtagtcct ttattagtat cccctttcgc taaatggtta 7320 tcttgatttc agaattctgg gaggatcact ttcagtgccg atatcccggc agtacgagca 7380 ctccgtacaa taactacacc aaacagtgca ccacaaagga gcgactttca cgccagaaca 7440 ctgacttcga ggaccagttg cagtttgtca gcgatgcggt gatggcattt gcatacgccc 7500 taaggtacga ttaagcttat tttggaagca acccactatc attttaaacg tattaagaaa 7560 ataatagttc ttttgatcaa cccttttagt ttttatcaac ctatggagta gcaataaata 7620 aaatgtaatg tgatttcctc tccttaggga tatgcaccgc gacctgtgcg gcggaggtcc 7680 ttcgctctgc gaggccatga agccaacgaa gggtgcagac ttgctgaaat atttgcgaaa 7740 agtggagttt gagggtgagt gagtaataga agccgtgtat ccacttttgc cggataaaag 7800 caagttaaat taacggagta actattcccg ggaattttca aaacaggatg tccgactgac 7860 tcagatccct ttgctctcgc ttagttcctt cagtcggcaa gtgatgcgca catagcttaa 7920 gtggaaattt cctgccaacc cgtccttgca gttgggccaa aagccccgca cacacactta 7980 cacacacaat ggcatatctc agcctgcgag agtcctacaa ggcgcattgg ccatgctttc 8040 gagtggaaaa ttgacttgct tgtcatcgtc attgaactcg attgaaattc aataaattac 8100 acagacagac ggacgggaag gagccaaagg ccctgactga ctagcgcaga ttgtcaattt 8160 tctgataggg cgagcgggca agcggcaaag tcggcgaagt cgtctctggc aggcgtgaaa 8220 ccataaaccc atttaactcc tattcgatca atccctccgc aggcctcagc ggcgacgagt 8280 tccgcttcga cgggaacggc gacggtcccg cccggtacaa catcatccac ttcaagcagt 8340 cccaggcggg acagtaccac tgggtcaagg tgggcgagta caccgagggc gagctgcggc 8400 ttaatatgac gggtaagata aagcccccag taggaaatac ttaaaagtat aataccagga 8460 acccttcaac attaagttta cctgactgaa ttcgtgcatc cttagtctcc tgtaacctaa 8520 tgtattcgtg ctcactgctc ctcatcaata ctaattttga tctcattatc ccgctaaccc 8580 agaggtgaag tttaagcggc tgagtcccaa gccgccggag tctgtctgca gcctgccatg 8640 tcttgtgggt caggccaaga agtacgtgga aggcgagagc tgctgttggc actgcttcaa 8700 ttgcacaacc tatcaagtaa gtgaagccca tctgaggcca gtaatttatt tgttggccct 8760 tcgaatagat tgaaatgtag cgccaagtga attattccgg aactaacgcg ttgacgggag 8820 atgggaaaaa tggggcaaaa acaattaagc catcaggcct gaaaggggct gcaagtgaat 8880 ggcaaacatg ccgcctttgt gctcgcccca tccatttatc aagtgttcct ttgtgcggtg 8940 cgtccattgc agatccgcca cccggatgac gagacccatt gcaagctgtg caagctgggc 9000 actcttcccg acgcccacaa gcagtactgc cgccccatcc cggagatata tttgcgtccg 9060 gagtccgctt gggccatcgg tgctatggcg ttcagtgcga ccgggatctt agtaacgctc 9120 ttcgtaatgg gcgtatttgt caggtgagca gcgcatacac cgtgataaaa acgggtatag 9180 gaaattactt ttaataatat ttaatagtta ttaatggctt ttataaaacc atttgaaaca 9240 attcagtctt aagatcgaac atttaacaat gaaatttgct ttctaaatcc aaaaacccat 9300 caggatgtta tattcctttt ctattaagac catttttaat aatacatagt ccaatattat 9360 cataaaacct tgttaatgta tatattttct caacttcaaa taatttagac aatatataat 9420 actttaacaa taattaaata atttgaagat aaggtaacgg gtatattata gtcaatgcat 9480 tcgttcttgt gtttataagt atagttattg ttatactagt gacaagctaa aggatctaga 9540 tcaagctgat ctgagtgcca aatatttcat gagggcctgt tttctagcta tgtttttctc 9600 tgactgtatt tattggcaca caattgtccg cttgcatgga tatggaaagc aattaaaaag 9660 tttcaccctt tccgggcaaa cttcgccaca aagttaaccg gcagacacat aaaaatgatg 9720 cattaattgg cgcaagaaaa cgtcgtcgca agtttgaaac tgaagtaacg cctttccctc 9780 cttcaccttc cacccaacag gcacaacgac acgcccatag tgcgtgcctc tggtcgggag 9840 ctgagctaca tcctgctggc ggggattttc atgtgctacg gtgtcacctt tgccctggtc 9900 ctgaagccga ccaacatagt gtgtgccatt cagcggtgag tgtgcaaatt gccgagatga 9960 tgcgtgtgaa ttttcctccg aaactccctc ttttccgctt ttccgcttcc acacaggttt 10020 ggtgtcggct tctgcttcac ggtcgtttat gcagcactgt tgaccaaaac gaatcgcatt 10080 gcacggatct tcaaagcggg caaacaatcc gccaagaggc cctccttcat tagtcccaag 10140 tcccagctgg taatctgtgc gtgcctggtt agtgtgcagg tgagtgtgtg gagtggtctg 10200 gtggcgctcc tggcggtgac cgacggggcg gatgtggaat cgagatgccc tgcgatgact 10260 ccgtgtcatt ctttccattc actccattcg cagatactca tcaacggcgt ttggatggta 10320 attgcgccat cacatgccat gcaccattat cccacacgcg aggataatct gctcgtctgc 10380 gactcgtaca tcgacgcctc ctacatgatt gcgttctcct acccaatctt cctgattgtt 10440 atttgcacgg tctacgcggt gctcacgcga aagattccgg aggctttcaa cgaatcgaag 10500 catattggtg agtaattgag ctttttattt ccagaagagc tataattcgg cgtaattggc 10560 attgtattgg aagggtctgt acaaaaagcc atgcatgggt ttgcattgtc tataacctgg 10620 ttcattatag cagcaatgct attaactggt ttatttagtg cataaaatag cacaacatgt 10680 atgaatgaac tccttataat ttagttatgt gttttgtatt tgggtaattt ggttatttcg 10740 aaacaataca cgcatgaaat atttataagt ctatatttta tgcattgcaa cctcagagtt 10800 ctagtgcaga aatgttttat aattatgaag ccataatgcc cataattggc cactttgatt 10860 gattacttaa ccctattgtt acaggattca ccatgtacac gacttgtgtg atttggctgg 10920 cttttgtacc gctctacttc ggaaccgcca accacgttcc gctgcgcatc accagcatgt 10980 cggtgaccat cagcttatcc gccagcgtga ccatcgcctg tctcttttcg cccaaggtga 11040 gtgagtccgg atagctggga gtgggttggg cttcggcttg gggggattca tatccacacg 11100 ggtcctctgt aaattgattg gtaattgcgt tatgcattaa ttattgcgca tttatctggc 11160 gaccgttgaa tgatttttgg tgccacagta tgcagaagcc atcggcgatt ttattccatt 11220 tcattccgtt tattcaggac gcgtggacga gtgtttcatt aaaatgcaat aagacggaag 11280 atgaggacag gcggaagcca agggtttggc aattcaacaa ccggctgcat cgattgcgat 11340 gtgttgcttc caaccatatt gtttttaatg cctacccttc ctcttggtcc atattccttg 11400 gtccttgccc atttcatgat gtttccccga gatgaagctt aaatgtcaac aagccatgtt 11460 ctcccacgga gctgaactgg tcatgatctc ctcccaaagg cgcgcgtcct ttatgttggc 11520 atactcggtc cccatgccaa catatttttt aatacgccct gctattagct attaagatgc 11580 aagtaaactg ccagacaagc caaatatagc cagccagttg agttcatgga ctagatgatg 11640 cagcatggca aagaagctgt ttaccccgat attaaacgtc aaggaggaag cttacattta 11700 agcactgata tcttcattac acggaaacac gacctttgac agcaatgtgc aatgtgaaac 11760 gcaggaaagg aattttataa gaaaatgtcg aatagcttgt ttgattattt tttttgtata 11820 agtattccaa gcatgaaagt tagatcagaa aatccaagtt atattggcaa ataatgaaag 11880 tctcttaatt gtatggctat taaaggggaa acacttttct agttagtttc caaaggcttc 11940 catataacac ttaaagatgc cagaaaggac cttcgccagt gtctatgcca ttgaagagca 12000 aggaggtaga aatagtaaat cagccagaaa cttgattagc aacggagcgg agctcccaca 12060 accgcacacg tcatagttct tggtcccgga gcggagcaag ctacagttta tggtctgtct 12120 gcatattccg ggtgcaaagt agaacaaaac ccggggaggc gaagggccgt aaacactcag 12180 caaaaggcta ttattaaatg tcggagtgga gcatacttct tggcccagtg gctgctaacc 12240 gggccaactg tacgctatca gatgtcacct aatgcacggt tggtttgcga cgaggaagga 12300 acactgtact gcgcacacgg caaatacagt gtgcacaagc acacgaaccg caccgtacac 12360 cttgagccat aaaaatgcaa tttacaactg gttgtgtctg gcaaaaggaa aacaataaaa 12420 ggctgccatg aatgcggcat gccacacaac aactggggat caccggacca agaggcaaca 12480 aactaaggcc ctggcgcaaa ggtgccggca gccacgcctc cttccgcagg acaaaggctg 12540 gcaaccgagg tggcaagcca ttccgacttc cgactgccac gcgccctttc tgctgtccgt 12600 ccggctctgc cgcagtttgt tttcgaactt gccgcgtttg tttgcggtga aaacaataac 12660 aaggggcgtc caaatggcag ccaaacaatg tcaaagcaaa gcggaaatga cccaccgtgc 12720 aggctacgta acagtacgca gcgtatcgca agttgaaacc tggagcactg ctcgcaattt 12780 gcgctaaatt ttcactaagc gttttataga tggtgccatt ctagtaagga gtatgtgtgc 12840 tctgaaccag gaactcgctc acgtggccaa aaacaaattc gatttggctt taaatatata 12900 ttagaaagtc aagacacctc aagaaattgg tgggaaagtg ttttcatgta ttgaatagta 12960 atcttattag cggtattttt tacacctcac tagtagagtg aaagggtaga ctagtttcgt 13020 tgaaaagtat gtaacaggta aaaacaagca tttaaagtat aaagattatt gattggaatc 13080 aatagcagat acgatctgac catgtccgtc cattcgtatt aacgtcgaaa ctaataagtt 13140 gagataaagc atactgattc cagagacgta gacgcagcac aagtttccgt attcaatatc 13200 cgttccggca gatctttcta tagtcgggga actcgactat agcgttccct aaattatatt 13260 taaattaatc aaacaaaaat gaacgaatgc gtgaacgtgt tatgatttaa tccgtctatt 13320 acattgttca ttgttatatt attcttaaag tgtaagtatg gtaatatggg gctcaggcgt 13380 gcacttctgc tccctgtaag tggcccaagt cgttggcctt tgctttgacc acattactgc 13440 tggccgtaga agcaggaaat ggctaatgac acttgaattt ggattaggaa tgggacttgg 13500 tggtgggcgt ggcaggtcac gcactgactt ctaatcaaag ccgtaagata agccatcttg 13560 gggaacaacg aaattggata tcgcctccaa atagctatta cacacaatgg gtcgttcgat 13620 taatgcctcg aacgggaaat taacctaatt ggaaagacgc actgcttttc tgactcgacc 13680 ctacgcttgt gtccttgcag ctgtacataa tactcatacg ccccgagcgc aacgtgcgcc 13740 agagtatgat gccgcctcgc tacggcaaca tgcaccgcac cgctggcaca ggaccctcgt 13800 ccatgatggc cgccgccgtg gtgaccgccg ccacctgtgc ccaggaggag aagatccaga 13860 agcatatcac tcccacaaac acaggtcagt aattaaggga tatcggttaa cgagtcccgg 13920 gtcagtaagc gtagcgctca aaatacacac acttcgtgtc gggcaaatgt attattgaca 13980 tatgtaattt gctgttgaat agtgcaatta agaggtataa cagttgcttg cctcgttaat 14040 cattatcgat caattaatca aattattgaa agtgagtcga ttttatctcc tgacaatgta 14100 ttaatcgtat tttgcaatga atttatatca attaaattat attactttat taacccattg 14160 caccagctgt acctatctct cgtattcatt tttaattttt gtggaaatgc ttcaattaat 14220 tgagaaaagt ttatcataaa ttgggtaata tagcaagtct taaaataact caagctgtaa 14280 aagctgaaca gttttatcaa agtaatagtt aggctgacaa tcaaaaggta tatccttctt 14340 aatttaattg attttaaaat gactaggata aagaataaaa ctgaattttt tccattcact 14400 acccataact tgcagaaaac tcgctaaaga cgaagaaatt gtgcgaaatg gccactcaga 14460 caatttccag tataatcacg tcgctggaca tcaatgcgta caatcaaata ccatatgccg 14520 atcaatatgt gccaaacaat gccacaacgg ccacgaccac gcccacagat aagggcagtg 14580 gcaacggcaa cagcaacagc aatagcaata cgaatggtag tagcaatagc aacagcaaca 14640 gcaatggcga tggcgatgtg gcaacagagc aagtcgtggc caacaataat aaaatcaatc 14700 agcgacaaca tggccagccg gccgtggcat ttgccatcac atcgactaac aatcacataa 14760 gcggcccagc agcaaccata acaacaacag cggcaactgg cgaaacaaca actgaggcgc 14820 tggtggctac aataacaact ccattggcaa cggtggatgg cagcgaaacc atgtccgtgg 14880 ctcccaacaa tgggcatgga aacaacggga gccaacgtcc gccggtcctg caaacaaact 14940 tatagctaaa cgcgcaacaa ttgcagcaac agctgctgaa ggagcagcag cgacaacaag 15000 ccgagctgca aacgcaacat ccgcagcagc aacatggaac acaaagctct tccagcgaca 15060 ccgccagcac gggcagcggc agtgcggcga agaagcgggc cgcaattccc gtttagctgc 15120 ccccggagat tcgagattct cgcaaccata cgtaagtaga ggaaagtgtc tgttgaccca 15180 agcgattccc ggcatcagtc tagggatgcg gaaaagcaga caagaggagg gcaggaggtc 15240 gtgctaggac gggactaaat tgggagcagc tgggccacag aaatatcttc agatcttaga 15300 aggcgaaata attcatttac cacttttgtt cgcttattaa tttgagtgaa ttctggttat 15360 accttacccc catagacaca aattatctta acgttctttt atataagttt atcgatagct 15420 gtacaacaat gtatctcaat aatgaagata ttcctgtggc acttaaggct ttcttcagat 15480 tttaacatgc acgcaagagt cataagtaag taagagtcgg ctgatcaaaa accttcgcaa 15540 ctcttcccaa aaacaaatgt gtttctccat tt 15572

<210> 5 <211> 2456 <212> DNA <213> Drosophila

<400> 5 ggtccatcag caacatagat gacgcggagt atcactgcaa taagacgcag gtgcgcaagg 60 tcatctcggg ggtggtgggt gccgcctcct cggtcacatc catacaagtt gccaatttat 120 tgcggttatt ccgaattccc caggtgtcgt acttctccac cagccccgag ctgagcaaca 180 aacagcgatt cgagtacttc tcccgcacta ttccctcgga tcactaccag gtgaaggcca 240 tggtggagat agtgaagcgg atgggatgga gctacgtgtc gattatctac gaggagagca 300 attacggaat caaggctttc gaggaactgg aggagctcct cgcacgccat aacatttgta 360 ttgccatcaa ggagaagctg gtgaaggatt cgggagtggc cgaggacatc gcctacgaca 420 atatagtgca gaagctgctg acgaagccgc gggctcgagg ggccattatc ttcggttcgg 480 atcaagaggt gcgccaagtg atgcgggcgg tgcgccgggc gaatgcaact ggttccttct 540 cctggatcgg atccgatggc tggagtgccc ggaatttggt gtccgacgac tacgagccgg 600 aggtggaagg cacgctgtct gtgcagccgc aggcgaatcc ggtgcgcggg ttcgaggagt 660 acttcctcag tctgacggtg gagaacaatc aacgcaatcc ctggtttgtg gaattctggg 720 aggatcactt tcagtgccga tatcccggca gtacgagcac tccgtacaat aactacacca 780 aacagtgcac cacaaaggag cgactttcac gccagaacac tgacttcgag gaccagttgc 840 agtttgtcag cgatgcggtg atggcatttg catacgccct aagggatatg caccgcgacc 900 tgtgcggcgg aggtccttcg ctctgcgagg ccatgaagcc aacgaagggt gcagacttgc 960 tgaaatattt gcgaaaagtg gagtttgagg gcctcagcgg cgacgagttc cgcttcgacg 1020 ggaacggcga cggtcccgcc cggtacaaca tcatccactt caagcagtcc caggcgggac 1080 agtaccactg ggtcaaggtg ggcgagtaca ccgagggcga gctgcggctt aatatgacgg 1140 aggtgaagtt taagcggctg agtcccaagc cgccggagtc tgtctgcagc ctgccatgtc 1200 ttgtgggtca ggccaagaag tacgtggaag gcgagagctg ctgttggcac tgcttcaatt 1260 gcacaaccta tcaaatccgc cacccggatg acgagaccca ttgcaagctg tgcaagctgg 1320 gcactcttcc cgacgcccac aagcagtact gccgccccat cccggagata tatttgcgtc 1380 cggagtccgc ttgggccatc ggtgctatgg cgttcagtgc gaccgggatc ttagtaacgc 1440 tcttcgtaat gggcgtattt gtcaggcaca acgacacgcc catagtgcgt gcctctggtc 1500 gggagctgag ctacatcctg ctggcgggga ttttcatgtg ctacggtgtc acctttgccc 1560 tggtcctgaa gccgaccaac atagtgtgtg ccattcagcg gtttggtgtc ggcttctgct 1620 tcacggtcgt ttatgcagca ctgttgacca aaacgaatcg cattgcacgg atcttcaaag 1680 cgggcaaaca atccgccaag aggccctcct tcattagtcc caagtcccag ctggtaatct 1740 gtgcgtgcct ggttagtgtg cagatactca tcaacggcgt ttggatggta attgcgccat 1800 cacatgccat gcaccattat cccacacgcg aggataatct gctcgtctgc gactcgtaca 1860 tcgacgcctc ctacatgatt gcgttctcct acccaatctt cctgattgtt atttgcacgg 1920 tctacgcggt gctcacgcga aagattccgg aggctttcaa cgaatcgaag catattggat 1980 tcaccatgta cacgacttgt gtgatttggc tggcttttgt accgctctac ttcggaaccg 2040 ccaaccacgt tccgctgcgc atcaccagca tgtcggtgac catcagctta tccgccagcg 2100 tgaccatcgc ctgtctcttt tcgcccaagc tgtacataat actcatacgc cccgagcgca 2160 acgtgcgcca gagtatgatg ccgcctcgct acggcaacat gcaccgcacc gctggcacag 2220 gaccctcgtc catgatggcc gccgccgtgg tgaccgccgc cacctgtgcc caggaggaga 2280 agatccagaa gcatatcact cccacaaaca cagacgaaga aattgtgcga aatggccact 2340 cagacaattt ccagtataat cacgtcgctg gacatcaatg cgtacaatca aataccatat 2400 gccgatcaat atgtgccaaa caatgccaca acggccacga ccacgcccac agataa 2456

<210> 6 <211> 738 <212> PRT <213> Drosophila

<400> 6

Met Val Glu He Val Lys Arg Met Gly Trp Ser Tyr Val Ser He He

1 5 10 15

Tyr Glu Glu Ser Asn Tyr Gly He Lys Ala Phe Glu Glu Leu Glu Glu

20 25 30

Leu Leu Ala Arg His Asn He Cys He Ala He Lys Glu Lys Leu Val

35 40 45

Lys Asp Ser Gly Val Ala Glu Asp He Ala Tyr Asp Asn He Val Gin

50 55 60

Lys Leu Leu Thr Lys Pro Arg Ala Arg Gly Ala He He Phe Gly Ser 65 70 75 80

Asp Gin Glu Val Arg Gin Val Met Arg Ala Val Arg Arg Ala Asn Ala

85 90 95

Thr Gly Ser Phe Ser Trp He Gly Ser Asp Gly Trp Ser Ala Arg Asn

100 105 110

Leu Val Ser Asp Asp Tyr Glu Pro Glu Val Glu Gly Thr Leu Ser Val

115 120 125

Gin Pro Gin Ala Asn Pro Val Arg Gly Phe Glu Glu Tyr Phe Leu Ser

130 135 140

Leu Thr Val Glu Asn Asn Gin Arg Asn Pro Trp Phe Val Glu Phe Trp 145 150 155 160

Glu Asp His Phe Gin Cys Arg Tyr Pro Gly Ser Thr Ser Thr Pro Tyr

165 170 175

Asn Asn Tyr Thr Lys Gin Cys Thr Thr Lys Glu Arg Leu Ser Arg Gin

180 185 190

Asn Thr Asp Phe Glu Asp Gin Leu Gin Phe Val Ser Asp Ala Val Met

195 200 205

Ala Phe Ala Tyr Ala Leu Arg Asp Met His Arg Asp Leu Cys Gly Gly

210 215 220

Gly Pro Ser Leu Cys Glu Ala Met Lys Pro Thr Lys Gly Ala Asp Leu 225 230 235 240

Leu Lys Tyr Leu Arg Lys Val Glu Phe Glu Gly Leu Ser Gly Asp Glu

245 250 255

Phe Arg Phe Asp Gly Asn Gly Asp Gly Pro Ala Arg Tyr Asn He He

260 265 270

His Phe Lys Gin Ser Gin Ala Gly Gin Tyr His Trp Val Lys Val Gly

275 280 285

Glu Tyr Thr Glu Gly Glu Leu Arg Leu Asn Met Thr Glu Val Lys Phe

290 295 300

Lys Arg Leu Ser Pro Lys Pro Pro Glu Ser Val Cys Ser Leu Pro Cys 305 310 315 320

Leu Val Gly Gin Ala Lys Lys Tyr Val Glu Gly Glu Ser Cys Cys Trp

325 330 335

His Cys Phe Asn Cys Thr Thr Tyr Gin He Arg His Pro Asp Asp Glu

340 345 350

Thr His Cys Lys Leu Cys Lys Leu Gly Thr Leu Pro Asp Ala His Lys 355 360 365

10 Gin Tyr Cys Arg Pro He Pro Glu He Tyr Leu Arg Pro Glu Ser Ala

370 375 380

Trp Ala He Gly Ala Met Ala Phe Ser Ala Thr Gly He Leu Val Thr 385 390 395 400

Leu Phe Val Met Gly Val Phe Val Arg His Asn Asp Thr Pro He Val

405 410 415

Arg Ala Ser Gly Arg Glu Leu Ser Tyr He Leu Leu Ala Gly He Phe

420 425 430

Met Cys Tyr Gly Val Thr Phe Ala Leu Val Leu Lys Pro Thr Asn He

435 440 445

Val Cys Ala He Gin Arg Phe Gly Val Gly Phe Cys Phe Thr Val Val

450 455 460

Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg He Ala Arg He Phe Lys 465 470 475 480

Ala Gly Lys Gin Ser Ala Lys Arg Pro Ser Phe He Ser Pro Lys Ser

485 490 495

Gin Leu Val He Cys Ala Cys Leu Val Ser Val Gin He Leu He Asn

500 505 510

Gly Val Trp Met Val He Ala Pro Ser His Ala Met His His Tyr Pro

515 520 525

Thr Arg Glu Asp Asn Leu Leu Val Cys Asp Ser Tyr He Asp Ala Ser

530 535 540

Tyr Met He Ala Phe Ser Tyr Pro He Phe Leu He Val He Cys Thr 545 550 555 560

Val Tyr Ala Val Leu Thr Arg Lys He Pro Glu Ala Phe Asn Glu Ser

565 570 575

Lys His He Gly Phe Thr Met Tyr Thr Thr Cys Val He Trp Leu Ala

580 585 590

Phe Val Pro Leu Tyr Phe Gly Thr Ala Asn His Val Pro Leu Arg He

595 600 605

Thr Ser Met Ser Val Thr He Ser Leu Ser Ala Ser Val Thr He Ala

610 615 620

Cys Leu Phe Ser Pro Lys Leu Tyr He He Leu He Arg Pro Glu Arg 625 630 635 640

Asn Val Arg Gin Ser Met Met Pro Pro Arg Tyr Gly Asn Met His Arg

645 650 655

Thr Ala Gly Thr Gly Pro Ser Ser Met Met Ala Ala Ala Val Val Thr

660 665 670

Ala Ala Thr Cys Ala Gin Glu Glu Lys He Gin Lys His He Thr Pro

675 680 685

Thr Asn Thr Asp Glu Glu He Val Arg Asn Gly His Ser Asp Asn Phe

690 695 700

Gin Tyr Asn His Val Ala Gly His Gin Cys Val Gin Ser Asn Thr He 705 710 715 720

Cys Arg Ser He Cys Ala Lys Gin Cys His Asn Gly His Asp His Ala

725 730 735

His Arg

<210> 7 <211> 9400 <212> DNA <213> Drosophila

<400> 7 cagttagttc ctagttaaca agtgaggttt ggttgaaatc tttctttgct atataggtat 60 ttcatttccg tatgctgtat cggttttgta aaataataaa gcatttcgcg agctctctct 120 ctctctgtat ctcaaaaata taaagtaaat gcccctatgt gtgtgcttaa agcatctaga 180 ttgatgaaaa tgtacacttc aaatgcttcg ctctggtttg cttacaacgt agctgaaatg 240 cagcaacaaa atggcaatgt attatttccc tttacttctt atattcctct tgattcgcag 300 ttggaaggaa ttttagttgt ataggtggaa aacggcagct ggatagcaag aaatgacaat 360 ctttcaaaac gtaggatatc tttttggttt atgaaacaca aaacaaatct taagcctgtg 420 tgtatatata tatatatctt acgagcataa tcagcgtaaa tcaaaaacaa ttgatttctt 480 acaaaataca taaaacataa ttcgcctgaa ttctatatat catgtacata cagttcctag 540 atcttataca tatacctaca tccatatata tatacttgat tttctggttg tttaaattag 600 tttttaagta tttaaaaatg gcatgtggtg acatgtatta caatacatca tacatatatg 660 gtacatacat ttatatttaa tatcgatttc caagttggta taaaatgcat gcaagtcgaa 720 gggcccgatt ccaattccaa ttccaacccc ccatcgctcg agttttggtt aagcttgcac 780 ggcaccgcag gggtatggat gtgccctatg gtctaggttt tagttatttc atatacattt 840 ataaagtttt gggattttcg aatcactgca cgtatagcat gacagcatgt tgtttcacac 900 aatgctccat atttcgacta acgactaata ctaggtatag ctagagatcc taagctacaa 960 tttttgccta agactgttcc gggggagttg cgttaactga tcacttagcc agtggttcca 1020 gataacatcg caccgtgttg ttctcatcga gcatggccga caggtggcgc tgctgatggt 1080 gcggaggatg ctgatgggga tgcggatggg ttagctggtg gggatgcgga ttgggattgc 1140 tgtgtgatgt atgcgacgac gatgatgtgg tggactgtgg tgacagtttc tgtagctgct 1200 ggcgcttctg cgcgggcgtc tgattcgccg gcggcagcgg tggtcccgag ttgccgtgac 1260 cgaatagctc atttaccgcc aaacggccgc ctggcgactt ggcattcagt gcttgctgct 1320 gctgctgccg gaatgcgcca cgcagggagc cctcaccaac gccgccgcta accccaaaaa 1380 ccgcaccgtt gtgctcgggt tgcggtcctg ctcctggtgg caaagccccg tagtcaagag 1440 gcgctccatg tttgcgcagc tgacgtctgt aaaggggata aatgtaattt tttcgtaacg 1500 ttgatatagt caaacattag aagtacttac tgaaaccgcc gcttaaaatc ctcgtcctgc 1560 atcgccatca gacgacgcat ccgctcatcg ctctgcggtg gcaatccatg agcatcatcc 1620 tccaagtcgc tctcgtcctc ctcctcatcc tcatcacaga cgctgtcgtg caattgctcc 1680 gcggccgttg cctcctcatc ctcctcctcg tcttcgtcgt catcgtcatc cgccgtgcag 1740 cgtcgagccg atctttgctg agccagcgac tgttgttgct gctgcttctt gagctgctgc 1800 tgttggctcc tggacgagac actgccgcca ctcaggcttc cgccgccgta ccgactaccg 1860 ccggcggcca ccgccgctct catgttgttg aagacgccag tgccaacgct attgttgtac 1920 acctcgtcca catcgaagtc acccacctcg taatgctgca catccgagtt gcggttgctg 1980 aggatctcct cgtagaccgg cccaccatcc gcgccgccga cgctgccttg gttgtagtag 2040 gcatcgccca tgcccagatc acagttggaa tgcttatttc tatactggcg ctgcataaac 2100 tcctgctggt actgcgccat gtgtggcggt ggagcaggga gctgctgctg gctaccagct 2160 cgtcgttgca ggtgcaacag gtgagcatgt tgctcggcct gctcctcgtc cgaggagagt 2220 tgctgctgct gctgctgttg ctgctgctga tgtagctgct ggcgacgcaa ctgttgctgc 2280 tgctggtagt aggcagccgc attgccagtg gctagtggtg ggtccaacgc ctccgcgtat 2340 tgcggatagc ctgttggctg gccaggcttg gtcttcttgt acgatggata gaaaagcacc 2400 tgggaggcgg cggccgtgcg actgtgcaga gatccactag gcgaggcggg aactcctccg 2460 gcgcccctct tctttttgcc attgtggccg ctgttcggct tttgagtcca gtagaatacc 2520 tcgtgcgcct gttgcggcga tgatgcagca gcacccgcat tattgtagta ctcccgcggt 2580 gttttcaatc ctcctgttcc agttgatggt tgcttccagc tgtagtagtc cggctgatgg 2640 tagtaagact cgcccaaagg tccctgttgc tgctgttgtt gttgttgctt gtgcgcaaaa 2700 atcaggtgtg tggacccggc agagctggtg ggtgaggcat gaccagtgga gcggagagtg 2760 ctacctcttt cgagcacaac atggccacca agggtctgcg gtggagcctg tagtgtgccc 2820 gtcattaggc cactttttag ggttcttctt tgctgggcct cgttcagttc acaatcagag 2880 gtggctccca taatggcatc ctctgtgatg ggcactggtg tctgctgttg ctgctgggga 2940 tcgtcatgcg cctcttcgct cactcctaac ggcagcttgg gcttcttgga cgtggagacg 3000 ctgcaaaggg ttccggctgt gggtccattg ccggtaacaa tgcccgagga aattgatgtt 3060 ttcgagcagc gcaagcactt gggcagccaa gcgtgctgtc tcacatactt ccgatactcc 3120 cgccggatct tttcgttttg aatgcaatgg aacacgaaga tatagagccc cagcaatgtg 3180 ttgaagcaga tgaagcagta tccatacaca tcagccgtgt catcgtccat tttggctcct 3240 cgcaaataga agtaggccga gcaccaaaca gcgctgagca gcaagaggaa cacaaaggag 3300 cagcgtatgt cgaacctagg atttgaggta catgggcatc gaaggatctt taaagtgtat 3360 atggattttc aatatcttac cgcacgctag cgaggcgagt atgttccttg gtctttagac 3420 ccgtgcgact tttgcggcac attataatcc aggagaggaa tgtgtaacca atggcagcct 3480 gtaaaagtga attaatttaa aatggtaact gcgcttttga agcttcatct catattatgt 3540 aacttaccac aaagaagaca agcactggta ttacaaaggt ggcataaaac aaggcattcg 3600 cctccatcag cacgcaataa tcgttttggg tataggtgct gggatcgatg accagcgaga 3660 tggccaccac gctcagcgac agtccgtagg acaagaggta gtagcagttc accttgggcg 3720 tctggtccac ctccagcagg agctcgtccg aggtgagcgt tgagtacgaa tggaaggctg 3780 cagaggcaaa gggttagggc tgcaaagtgt agatgaaatt cggccttctt accttcgtaa 3840 cagaaccagg cggtgcccga taggatggca cagtgtagga aaatagtaat gaagccgcag 3900 aaaatgcttg tttcggtctg ttcaatgccc aggagaaaga gcagctcgat ggccaggagg 3960 caaaggtaaa tgctggtata gatcgaggtg cgcgcggact ggagtggaca gttaaagaga 4020 agacagagtg aaaagttaat ataagttcga gaagtcagtg caaatttttt ctttaagcag 4080 caccagcaga aggaccctaa agattcgatc atcagggagc ttttagacat tttaaggaaa 4140 ttgataatct taaacgtttt gaagaatagg tgtcagattt gatagtcaaa cttaatttag 4200 aacttgattt acaataattt tggtgggtgg tggtgaaaat ccaaagacta agagtaatac 4260 gaatacgaat aaaacaatga acagaacacg aaacaagcac aacacatagg taatatacat 4320 acaaactaaa tgaacaaaca caaaatgcaa tatttacagg acaaaattag caacatttgt 4380 atattttatt aattaatgaa atacaaaaga aagtcagaag tgttctaggt atttagttgt 4440 acgatgtcta tgttaaattt gttaaacaat caatgcacat aaaaggggtt atggtatttc 4500 aaaaatgatt aaacgattaa gtaaaacatg ccagagtgat gatttgtaac aaaaagaaaa 4560 atgagtctat catatgaaga tatttcatta ttggttttgt gtgctaatct taagctatga 4620 caaattacta cgatacataa atataaatgg gagtcttcgc gtgcaagctg ttactgggac 4680 gcaacagtga tcatcgctgc ccagcacagc ttttgagtct tatctttgaa tcctgccaga 4740 gagaggttca ttaacaattt aagttactta agcattatat cacatgtgtc tctcggtcat 4800 aaatacatat gtctagaaag cctagcctag cctaaaattg tgtttatctg ttttttcacc 4860 accaccacca cttatattgt aagtcgtcca tgttggcctg cataatgatg ttgttcgtgt 4920 tatccaatcc attgccgtcc acattaaggt tgtgattgcg gtgcggatgt ggctgcggct 4980 gctggccacg ctgctgctgc tgctgctgct ggacatgctg ctgctgcaga tagttgtggc 5040 tgatgttgag gttattgctg gcgttgctgg cctgaactgc atgttgctgc agtgcagcgg 5100 ctattgaggc agcagcagct gcagcagcag ccgtctgctg accgtgctga tgcagattca 5160 gattcaagtt gttcatggca tgttgcatat ttcgctgcgg ctgattggac agcacaacag 5220 cagcagcagc tgccgcaaca acttgttgtt gctgttgctg ctgctgctgt tggacattgt 5280 agttcagatt gttgcggtgt gagttgcgga tggaattgtg ttggataaag ttcgtgttcc 5340 catgactggg cggcggcaca ttggactgac tggttggcgt ggtcagggtc aaggactcgt 5400 gggtctggtc gcgaatattg ttttgctggc gtctgctgcc cgaccgctga tgcggcaagg 5460 gattggagcc gtttcttacc ttcacaaaga ccccattgaa cagcttcagc gttagcaggg 5520 cgataactat gaagaccacg cagatgccga tgcttatgta gatgaatatg cgcatgtttc 5580 catcgaacat ggtgaacaac gaatgctggt gctcatccac aacgtccatt agtatggcaa 5640 agtttgtcag gtggttgcaa ctgcagacgc tgtgcgtgcg gttagtggac tccagactgc 5700 atccgttggc agaccacgca ctaaaacaaa aacattaatt cgtataaatt attaggcata 5760 tgagcatatg agtcttactg gtcaatatag ttccagaaca cgcaggtggg attcgttaca 5820 ttctcggtct tcagatgttt cagtgtcagg gttatgggct gggagagttg tatgtgacgc 5880 cccttgccca agctggccga gatcaccttg ctgttcagga tgcgtaggcg ctgttggatc 5940 tcccccgcgt tgacatcgct gtcgttgctc aggatggctg tattgcgaac taagaaaaca 6000 tttagattat actattctaa cgtttttcag ttctctgtgg acttaccgta actgcgggag 6060 ctcttgagat cgaagtgatc atagctgggc tttagaatgg attccaggcg atcgaaggcg 6120 gcgaatacaa ttcgcaccag accgccttca ctattatcta ttagagcagc tcgtggcagc 6180 tcaatacgat ccgaactcaa gggccactga tccgaatctg ggaagaccac gctggactgg 6240 atagtcttgg tttccagaac tcgaacggag agcactatgg tgatatacag ttataagtat 6300 tttgaaatgc aaacaatgca aacatttaga actcacatat atttttgact ttttgcacca 6360 cgctgcgctc cctgatgatc gtatccgcca gcagaaaggc attgtattcc aggccagtta 6420 gcaaggatgt ggctacacgc atttggtcct ccggattgag atccaaccac gaggacagct 6480 gcgattcgtc cagcaggttg gagccggttt tgaccacaca atgcaacaac tccatgatca 6540 tagcctcgcg ctgtcgctga tccgggaagg tctccttgtc gtgcatcatc ttctcggaca 6600 ctgtttggat aatcttcgtg gtgaccaaca tgtcgccgcc gtagagcgtt ttgctactgg 6660 tcacttcgga catatcgttg gcgatggaga tcaaggagga gtcccgctgg tttactcgca 6720 tttccagatt gttgagccaa aggctgcggc attgcgtcag atcaggtgtc gcgggatgcc 6780 aggtgggctc aaagttgcgc agacgctggt ttaccttgtg ggccatgctc accggcggct 6840 cgcagctgct gctgttgtgc agacagtcgc caccgctggg tgccggagtt gtcgaactga 6900 tgtcatcatc gtactcatcg tagccggagt cgggtatcct cttcattaga acgcaacgcc 6960 acttggcgat gccggctgct ccgccaggac agggctgaac attcacatca cccactcgag 7020 tcatgttcca gtacaaattg cgggcatgag tggggccgca aaacaacttg gactcatcat 7080 cgcctccgga catcccggct gcgttcaaat taatattgtt gatggtgcgc accacgctgc 7140 cgttcccggg gacaacggat ccactggccg cagtgcccgg tgggcggttg ggtgagctct 7200 ttgtggtcag tagggttccg tcatcagttc cggaacctcc gacgcccgtg agtatcctcg 7260 tgttggatgg tgaagtggca ttaccgccag ccggcagctt gctgctcggc ttggtgggtg 7320 aggcagtgtc ttcaccgtgg tggttgtggt ggtggtgcag ttgcggcggc ggtggcagac 7380 catcatggcg gccagccgga tgcttggtgg tcgtcgtgga ggtggcccca cccttcaaac 7440

13 gtccaccgcc cacggctgtc gtgctgctcg agggcgtgga gtgcgtgacg gcggtgtgtt 7500 gcggtggtac gttgaacagg ccgggattcc cactgattcc caccactccg ggaagtgtgg 7560 gaagtctcgg cgggggcggc gcacccgctc caaccccggg cggatggatc agtccactgc 7620 cgttgccaaa gatcggcgga ccattgctca gcacccatgg cggcggactg ggcctgttgg 7680 tcgtcgtcga agtttgggct gcacttatgc actggtagtg tgcctccaga tacttgtggg 7740 taccgggaca gggatccccg aacatgctcg tggctgccaa cacgccgcag ctctgcttgt 7800 gggcacatct ggaaaatggg aaaaatacgc gttcatcagt aaacagagtt gggtaatttt 7860 cacatattta agatgcttga ttgattgact tgtgttgaaa tagtttattg atattcgcaa 7920 ccagagtatg aaatttccaa atgacatgtt taatgatttg aagatccaat aaactttaaa 7980 agatgtatta ccttgagttc agtacgctga gtgacttggg aaacatgcag ttaacactcc 8040 actccacatt cccgtggtca ttgcagatgg taatcgagaa gcggccatag ttggcccgaa 8100 tgaggttgat cacatcgccg ggatcgcact cgatggtcag tttcttacct tcgcaggcgt 8160 aggcggtttg gtacttggac actgaaaggc gaaggcttca taagtcacag ggtgctgggc 8220 agggtatggg tttatatgga catggtatat atatatggca tataaaaaga aattttttgg 8280 ttagcggcga tgattgttgt agtttggttt ggtttggatt ggattgttgg tgggcctgca 8340 aagacactta cgatctaacg atatatgctc ataggatatt gacaatatgg ttggtagcat 8400 gatacgcttt tacactgcct gggatatact tagtaatgct gaggttgatg gtggagtatg 8460 tgggtcgtta gcttggtagc aagtgcaata gtagtcataa ataccaaatc ctgccggccc 8520 agatcacgaa tcatcgatcg tccatcattg gttcttatcg gcaatgctca ttcggcagtg 8580 tttcactcgg tttgaagtat tcaaactgaa agggaagata acatttataa tgtttggtat 8640 tattattatt attattttaa ggcacataac taataactta agacatgttg tatttcgtta 8700 gaaaggaaaa ggagaactat ccttttcttt tattgatatt ggttccattt aatttacttg 8760 tgcaatatca catcaatgtt gagtcaatct aatgacctgg ttacagtaaa tatcaaaagt 8820 gtagattcta ataaatttaa gttattttaa tattcagaac ctctttgtat aactcctatt 8880 aaaacactat ataagcaatg caaatatcaa gaaaacataa ttaattgtaa gaattataaa 8940 ttgcatttat atatctttaa taattaaaat ggtcttatat ttatgtatga tgatatccag 9000 gccaagcaca cctatgtaca tatgtacata cctcttatgt atttccgttt ggagtcatat 9060 tcatgaaagt tggactcaaa agtaccattc aacttatgta tctgaaaggt agagaatcca 9120 ttagataatt gtttacatat tgactccttg ggcaaacacg aacaagcagg caaaagacaa 9180 atagaagata agaagatggc atggggcagg ggagggggta gggtagggag ctaagaatac 9240 acacccttct gtgtacaccc acactgtggt tgtagttgtt gcatggccat cgattcgtgg 9300 acagaacaaa gacccgtttt ctttgtacac ccgatgcaca ctattcacga acatatatgc 9360 atgtggatgt aaatgtagag aaaagttgct gcagctgcgc 9400

<210> 8

<211> 5718

<212> DNA

<213> Drosophila

<400> 8 atgctaccaa ccatattgtc aatatcctat gagcatatat cgttagatct gtccaagtac 60 caaaccgcct acgcctgcga aggtaagaaa ctgaccatcg agtgcgatcc cggcgatgtg 120 atcaacctca ttcgggccaa ctatggccgc ttctcgatta ccatctgcaa tgaccacggg 180 aatgtggagt ggagtgttaa ctgcatgttt cccaagtcac tcagcgtact gaactcaaga 240 tgtgcccaca agcagagctg cggcgtgttg gcagccacga gcatgttcgg ggatccctgt 300 cccggtaccc acaagtatct ggaggcacac taccagtgca taagtgcagc ccaaacttcg 360 acgacgacca acaggcccag tccgccgcca tgggtgctga gcaatggtcc gccgatcttt 420 ggcaacggca gtggactgat ccatccgccc ggggttggag cgggtgcgcc gcccccgccg 480 agacttccca cacttcccgg agtggtggga atcagtggga atcccggcct gttcaacgta 540 ccaccgcaac acaccgccgt cacgcactcc acgccctcga gcagcacgac agccgtgggc 600 ggtggacgtt tgaagggtgg ggccacctcc acgacgacca ccaagcatcc ggctggccgc 660 catgatggtc tgccaccgcc gccgcaactg caccaccacc acaaccacca cggtgaagac 720 actgcctcac ccaccaagcc gagcagcaag ctgccggctg gcggtaatgc cacttcacca 780 tccaacacga ggatactcac gggcgtcgga ggttccggaa ctgatgacgg aaccctactg 840 accacaaaga gctcacccaa ccgcccaccg ggcactgcgg ccagtggatc cgttgtcccc 900 gggaacggca gcgtggtgcg caccatcaac aatattaatt tgaacgcagc cgggatgtcc 960 ggaggcgatg atgagtccaa gttgttttgc ggccccactc atgcccgcaa tttgtactgg 1020 aacatgactc gagtgggtga tgtgaatgtt cagccctgtc ctggcggagc agccggcatc 1080

14 gccaagtggc gttgcgttct aatgaagagg atacccgact ccggctacga tgagtacgat 1140 gatgacatca gttcgacaac tccggcaccc agcggtggcg actgtctgca caacagcagc 1200 agctgcgagc cgccggtgag catggcccac aaggtaaacc agcgtctgcg caactttgag 1260 cccacctggc atcccgcgac acctgatctg acgcaatgcc gcagcctttg gctcaacaat 1320 ctggaaatgc gagtaaacca gcgggactcc tccttgatct ccatcgccaa cgatatgtcc 1380 gaagtgacca gtagcaaaac gctctacggc ggcgacatgt tggtcaccac gaagattatc 1440 caaacagtgt ccgagaagat gatgcacgac aaggagacct tcccggatca gcgacagcgc 1500 gaggctatga tcatggagtt gttgcattgt gtggtcaaaa ccggctccaa cctgctggac 1560 gaatcgcagc tgtcctcgtg gttggatctc aatccggagg accaaatgcg tgtagccaca 1620 tccttgctaa ctggcctgga atacaatgcc tttctgctgg cggatacgat catcagggag 1680 cgcagcgtgg tgcaaaaagt caaaaatata ttgctctccg ttcgagttct ggaaaccaag 1740 actatccagt ccagcgtggt cttcccagat tcggatcagt ggcccttgag ttcggatcgt 1800 attgagctgc cacgagctgc tctaatagat aatagtgaag gcggtctggt gcgaattgta 1860 ttcgccgcct tcgatcgcct ggaatccatt ctaaagccca gctatgatca cttcgatctc 1920 aagagctccc gcagttacgc catcctgagc aacgacagcg atgtcaacgc gggggagatc 1980 caacagcgcc tacgcatcct gaacagcaag gtgatctcgg ccagcttggg caaggggcgt 2040 cacatacaac tctcccagcc cataaccctg acactgaaac atctgaagac cgagaatgta 2100 acgaatccca cctgcgtgtt ctggaactat attgaccatg cgtggtctgc caacggatgc 2160 agtctggagt ccactaaccg cacgcacagc gtctgcagtt gcaaccacct gacaaacttt 2220 gccatactaa tggacgttgt ggatgagcac cagcattcgt tgttcaccat gttcgatgga 2280 aacatgcgca tattcatcta cataagcatc ggcatctgcg tggtcttcat agttatcgcc 2340 ctgctaacgc tgaagctgtt caatggggtc tttgtgaagg taagaaacgg ctccaatccc 2400 ttgccgcatc agcggtcggg cagcagacgc cagcaaaaca atattcgcga ccagacccac 2460 gagtccttga ccctgaccac gccaaccagt cagtccaatg tgccgccgcc cagtcatggg 2520 aacacgaact ttatccaaca caattccatc cgcaactcac accgcaacaa tctgaactac 2580 aatgtccaac agcagcagca gcaacagcaa caacaagttg ttgcggcagc tgctgctgct 2640 gttgtgctgt ccaatcagcc gcagcgaaat atgcaacatg ccatgaacaa cttgaatctg 2700 aatctgcatc agcacggtca gcagacggct gctgctgcag ctgctgctgc ctcaatagcc 2760 gctgcactgc agcaacatgc agttcaggcc agcaacgcca gcaataacct caacatcagc 2820 cacaactatc tgcagcagca gcatgtccag cagcagcagc agcagcagcg tggccagcag 2880 ccgcagccac atccgcaccg caatcacaac cttaatgtgg acggcaatgg attggataac 2940 acgaacaaca tcattatgca ggccaacatg gacgacttac aatataagtg gtggtggtgc 3000 atttaccttt gcctcctggc catcgagctg ctctttctcc tgggcattga acagaccgaa 3060 acaagcattt tctgcggctt cattactatt ttcctacact gtgccatcct atcgggcacc 3120 gcctggttct gttacgaagc cttccattcg tactcaacgc tcacctcgga cgagctcctg 3180 ctggaggtgg accagacgcc caaggtgaac tgctactacc tcttgtccta cggactgtcg 3240 ctgagcgtgg tggccatctc gctggtcatc gatcccagca cctataccca aaacgattat 3300 tgcgtgctga tggaggcgaa tgccttgttt tatgccacct ttgtaatacc agtgcttgtc 3360 ttctttgtgg ctgccattgg ttacacattc ctctcctgga ttataatgtg ccgcaaaagt 3420 cgcacgggtc taaagaccaa ggaacatact cgcctcgcta gcgtgcggtt cgacatacgc 3480 tgctcctttg tgttcctctt gctgctcagc gctgtttggt gctcggccta cttctatttg 3540 cgaggagcca aaatggacga tgacacggct gatgtgtatg gatactgctt catctgcttc 3600 aacacattgc tggggctcta tatcttcgtg ttccattgca ttcaaaacga aaagatccgg 3660 cgggagtatc ggaagtatgt gagacagcac gcttggctgc ccaagtgctt gcgctgctcg 3720 aaaacatcaa tttcctcggg cattgttacc ggcaatggac ccacagccgg aaccctttgc 3780 agcgtctcca cgtccaagaa gcccaagctg ccgttaggag tgagcgaaga ggcgcatgac 3840 gatccccagc agcaacagca gacaccagtg cccatcacag aggatgccat tatgggagcc 3900 acctctgatt gtgaactgaa cgaggcccag caaagaagaa ccctaaaaag tggcctaatg 3960 acgggcacac tacaggctcc accgcagacc cttggtggcc atgttgtgct cgaaagaggt 4020 agcactctcc gctccactgg tcatgcctca cccaccagct ctgccgggtc cacacacctg 4080 atttttgcgc acaagcaaca acaacaacag cagcaacagg gacctttggg cgagtcttac 4140 taccatcagc cggactacta cagctggaag caaccatcaa ctggaacagg aggattgaaa 4200 acaccgcggg agtactacaa taatgcgggt gctgctgcat catcgccgca acaggcgcac 4260 gaggtattct actggactca aaagccgaac agcggccaca atggcaaaaa gaagaggggc 4320 gccggaggag ttcccgcctc gcctagtgga tctctgcaca gtcgcacggc cgccgcctcc 4380 caggtgcttt tctatccatc gtacaagaag accaagcctg gccagccaac aggctatccg 4440 caatacgcgg aggcgttgga cccaccacta gccactggca atgcggctgc ctactaccag 4500 cagcagcaac agttgcgtcg ccagcagcta catcagcagc agcaacagca gcagcagcag 4560 caactctcct cggacgagga gcaggccgag caacatgctc acctgttgca cctgcaacga 4620 cgagctggta gccagcagca gctccctgct ccaccgccac acatggcgca gtaccagcag 4680

15 gagtttatgc agcgccagta tagaaataag cattccaact gtgatctggg catgggcgat 4740 gcctactaca accaaggcag cgtcggcggc gcggatggtg ggccggtcta cgaggagatc 4800 ctcagcaacc gcaactcgga tgtgcagcat tacgaggtgg gtgacttcga tgtggacgag 4860 gtgtacaaca atagcgttgg cactggcgtc ttcaacaaca tgagagcggc ggtggccgcc 4920 ggcggtagtc ggtacggcgg cggaagcctg agtggcggca gtgtctcgtc caggagccaa 4980 cagcagcagc tcaagaagca gcagcaacaa cagtcgctgg ctcagcaaag atcggctcga 5040 cgctgcacgg cggatgacga tgacgacgaa gacgaggagg aggatgagga ggcaacggcc 5100 gcggagcaat tgcacgacag cgtctgtgat gaggatgagg aggaggacga gagcgacttg 5160 gaggatgatg ctcatggatt gccaccgcag agcgatgagc ggatgcgtcg tctgatggcg 5220 atgcaggacg aggattttaa gcggcggttt caacgtcagc tgcgcaaaca tggagcgcct 5280 cttgactacg gggctttgcc accaggagca ggaccgcaac ccgagcacaa cggtgcggtt 5340 tttggggtta gcggcggcgt tggtgagggc tccctgcgtg gcgcattccg gcagcagcag 5400 cagcaagcac tgaatgccaa gtcgccaggc ggccgtttgg cggtaaatga gctattcggt 5460 cacggcaact cgggaccacc gctgccgccg gcgaatcaga cgcccgcgca gaagcgccag 5520 cagctacaga aactgtcacc acagtccacc acatcatcgt cgtcgcatac atcacacagc 5580 aatcccaatc cgcatcccca ccagctaacc catccgcatc cccatcagca tcctccgcac 5640 catcagcagc gccacctgtc ggccatgctc gatgagaaca acacggtgcg atgttatctg 5700 gaaccactgg ctaagtga 5718

<210> 9

<211> 1905

<212> PRT

<213> Drosophila

<400> 9

Met Leu Pro Thr He Leu Ser He Ser Tyr Glu His He Ser Leu Asp

1 5 10 15

Leu Ser Lys Tyr Gin Thr Ala Tyr Ala Cys Glu Gly Lys Lys Leu Thr 20 25 30

He Glu Cys Asp Pro Gly Asp Val He Asn Leu He Arg Ala Asn Tyr 35 40 45

Gly Arg Phe Ser He Thr He Cys Asn Asp His Gly Asn Val Glu Trp

50 55 60

Ser Val Asn Cys Met Phe Pro Lys Ser Leu Ser Val Leu Asn Ser Arg

65 70 75 80

Cys Ala His Lys Gin Ser Cys Gly Val Leu Ala Ala Thr Ser Met Phe 85 90 95

Gly Asp Pro Cys Pro Gly Thr His Lys Tyr Leu Glu Ala His Tyr Gin 100 105 110

Cys He Ser Ala Ala Gin Thr Ser Thr Thr Thr Asn Arg Pro Ser Pro 115 120 125

Pro Pro Trp Val Leu Ser Asn Gly Pro Pro He Phe Gly Asn Gly Ser 130 135 140

Gly Leu He His Pro Pro Gly Val Gly Ala Gly Ala Pro Pro Pro Pro

145 150 155 160

Arg Leu Pro Thr Leu Pro Gly Val Val Gly He Ser Gly Asn Pro Gly 165 170 175

Leu Phe Asn Val Pro Pro Gin His Thr Ala Val Thr His Ser Thr Pro 180 185 190

Ser Ser Ser Thr Thr Ala Val Gly Gly Gly Arg Leu Lys Gly Gly Ala 195 200 205

Thr Ser Thr Thr Thr Thr Lys His Pro Ala Gly Arg His Asp Gly Leu 210 215 220

Pro Pro Pro Pro Gin Leu His His His His Asn His His Gly Glu Asp

225 230 235 240

Thr Ala Ser Pro Thr Lys Pro Ser Ser Lys Leu Pro Ala Gly Gly Asn

245 250 255

Ala Thr Ser Pro Ser Asn Thr Arg He Leu Thr Gly Val Gly Gly Ser

16 260 265 270

Gly Thr Asp Asp Gly Thr Leu Leu Thr Thr Lys Ser Ser Pro Asn Arg

275 280 285

Pro Pro Gly Thr Ala Ala Ser Gly Ser Val Val Pro Gly Asn Gly Ser

290 295 300

Val Val Arg Thr He Asn Asn He Asn Leu Asn Ala Ala Gly Met Ser 305 310 315 320

Gly Gly Asp Asp Glu Ser Lys Leu Phe Cys Gly Pro Thr His Ala Arg

325 330 335

Asn Leu Tyr Trp Asn Met Thr Arg Val Gly Asp Val Asn Val Gin Pro

340 345 350

Cys Pro Gly Gly Ala Ala Gly He Ala Lys Trp Arg Cys Val Leu Met

355 360 365

Lys Arg He Pro Asp Ser Gly Tyr Asp Glu Tyr Asp Asp Asp He Ser

370 375 380

Ser Thr Thr Pro Ala Pro Ser Gly Gly Asp Cys Leu His Asn Ser Ser 385 390 395 400

Ser Cys Glu Pro Pro Val Ser Met Ala His Lys Val Asn Gin Arg Leu

405 410 415

Arg Asn Phe Glu Pro Thr Trp His Pro Ala Thr Pro Asp Leu Thr Gin

420 425 430

Cys Arg Ser Leu Trp Leu Asn Asn Leu Glu Met Arg Val Asn Gin Arg

435 440 445

Asp Ser Ser Leu He Ser He Ala Asn Asp Met Ser Glu Val Thr Ser

450 455 460

Ser Lys Thr Leu Tyr Gly Gly Asp Met Leu Val Thr Thr Lys He He 465 470 475 480

Gin Thr Val Ser Glu Lys Met Met His Asp Lys Glu Thr Phe Pro Asp

485 490 495

Gin Arg Gin Arg Glu Ala Met He Met Glu Leu Leu His Cys Val Val

500 505 510

Lys Thr Gly Ser Asn Leu Leu Asp Glu Ser Gin Leu Ser Ser Trp Leu

515 520 525

Asp Leu Asn Pro Glu Asp Gin Met Arg Val Ala Thr Ser Leu Leu Thr

530 535 540

Gly Leu Glu Tyr Asn Ala Phe Leu Leu Ala Asp Thr He He Arg Glu 545 550 555 560

Arg Ser Val Val Gin Lys Val Lys Asn He Leu Leu Ser Val Arg Val

565 570 575

Leu Glu Thr Lys Thr He Gin Ser Ser Val Val Phe Pro Asp Ser Asp

580 585 590

Gin Trp Pro Leu Ser Ser Asp Arg He Glu Leu Pro Arg Ala Ala Leu

595 600 605

He Asp Asn Ser Glu Gly Gly Leu Val Arg He Val Phe Ala Ala Phe

610 615 620

Asp Arg Leu Glu Ser He Leu Lys Pro Ser Tyr Asp His Phe Asp Leu 625 630 635 640

Lys Ser Ser Arg Ser Tyr Ala He Leu Ser Asn Asp Ser Asp Val Asn

645 650 655

Ala Gly Glu He Gin Gin Arg Leu Arg He Leu Asn Ser Lys Val He

660 665 670

Ser Ala Ser Leu Gly Lys Gly Arg His He Gin Leu Ser Gin Pro He

675 680 685

Thr Leu Thr Leu Lys His Leu Lys Thr Glu Asn Val Thr Asn Pro Thr

690 695 700

Cys Val Phe Trp Asn Tyr He Asp His Ala Trp Ser Ala Asn Gly Cys 705 710 715 720

Ser Leu Glu Ser Thr Asn Arg Thr His Ser Val Cys Ser Cys Asn His

725 730 735

Leu Thr Asn Phe Ala He Leu Met Asp Val Val Asp Glu His Gin His

17 740 745 750

Ser Leu Phe Thr Met Phe Asp Gly Asn Met Arg He Phe He Tyr He

755 760 765

Ser He Gly He Cys Val Val Phe He Val He Ala Leu Leu Thr Leu

770 775 780

Lys Leu Phe Asn Gly Val Phe Val Lys Val Arg Asn Gly Ser Asn Pro 785 790 795 800

Leu Pro His Gin Arg Ser Gly Ser Arg Arg Gin Gin Asn Asn He Arg

805 810 815

Asp Gin Thr His Glu Ser Leu Thr Leu Thr Thr Pro Thr Ser Gin Ser

820 825 830

Asn Val Pro Pro Pro Ser His Gly Asn Thr Asn Phe He Gin His Asn

835 840 845

Ser He Arg Asn Ser His Arg Asn Asn Leu Asn Tyr Asn Val Gin Gin

850 855 860

Gin Gin Gin Gin Gin Gin Gin Gin Val Val Ala Ala Ala Ala Ala Ala 865 870 875 880

Val Val Leu Ser Asn Gin Pro Gin Arg Asn Met Gin His Ala Met Asn

885 890 895

Asn Leu Asn Leu Asn Leu His Gin His Gly Gin Gin Thr Ala Ala Ala

900 905 910

Ala Ala Ala Ala Ala Ser He Ala Ala Ala Leu Gin Gin His Ala Val

915 920 925

Gin Ala Ser Asn Ala Ser Asn Asn Leu Asn He Ser His Asn Tyr Leu

930 935 940

Gin Gin Gin His Val Gin Gin Gin Gin Gin Gin Gin Arg Gly Gin Gin 945 950 955 960

Pro Gin Pro His Pro His Arg Asn His Asn Leu Asn Val Asp Gly Asn

965 970 975

Gly Leu Asp Asn Thr Asn Asn He He Met Gin Ala Asn Met Asp Asp

980 985 990

Leu Gin Tyr Lys Trp Trp Trp Cys He Tyr Leu Cys Leu Leu Ala He

995 1000 1005

Glu Leu Leu Phe Leu Leu Gly He Glu Gin Thr Glu Thr Ser He Phe

1010 1015 1020

Cys Gly Phe He Thr He Phe Leu His Cys Ala He Leu Ser Gly Thr 1025 1030 1035 1040

Ala Trp Phe Cys Tyr Glu Ala Phe His Ser Tyr Ser Thr Leu Thr Ser

1045 1050 1055

Asp Glu Leu Leu Leu Glu Val Asp Gin Thr Pro Lys Val Asn Cys Tyr

1060 1065 1070

Tyr Leu Leu Ser Tyr Gly Leu Ser Leu Ser Val Val Ala He Ser Leu

1075 1080 1085

Val He Asp Pro Ser Thr Tyr Thr Gin Asn Asp Tyr Cys Val Leu Met

1090 1095 1100

Glu Ala Asn Ala Leu Phe Tyr Ala Thr Phe Val He Pro Val Leu Val 1105 1110 1115 1120

Phe Phe Val Ala Ala He Gly Tyr Thr Phe Leu Ser Trp He He Met

1125 1130 1135

Cys Arg Lys Ser Arg Thr Gly Leu Lys Thr Lys Glu His Thr Arg Leu

1140 1145 1150

Ala Ser Val Arg Phe Asp He Arg Cys Ser Phe Val Phe Leu Leu Leu

1155 1160 1165

Leu Ser Ala Val Trp Cys Ser Ala Tyr Phe Tyr Leu Arg Gly Ala Lys

1170 1175 1180

Met Asp Asp Asp Thr Ala Asp Val Tyr Gly Tyr Cys Phe He Cys Phe 1185 1190 1195 1200

Asn Thr Leu Leu Gly Leu Tyr He Phe Val Phe His Cys He Gin Asn

1205 1210 1215

Glu Lys He Arg Arg Glu Tyr Arg Lys Tyr Val Arg Gin His Ala Trp 1220 1225 1230

Leu Pro Lys Cys Leu Arg Cys Ser Lys Thr Ser He Ser Ser Gly He

1235 1240 1245

Val Thr Gly Asn Gly Pro Thr Ala Gly Thr Leu Cys Ser Val Ser Thr

1250 1255 1260

Ser Lys Lys Pro Lys Leu Pro Leu Gly Val Ser Glu Glu Ala His Asp 1265 1270 1275 1280

Asp Pro Gin Gin Gin Gin Gin Thr Pro Val Pro He Thr Glu Asp Ala

1285 1290 1295

He Met Gly Ala Thr Ser Asp Cys Glu Leu Asn Glu Ala Gin Gin Arg

1300 1305 1310

Arg Thr Leu Lys Ser Gly Leu Met Thr Gly Thr Leu Gin Ala Pro Pro

1315 1320 1325

Gin Thr Leu Gly Gly His Val Val Leu Glu Arg Gly Ser Thr Leu Arg

1330 1335 1340

Ser Thr Gly His Ala Ser Pro Thr Ser Ser Ala Gly Ser Thr His Leu 1345 1350 1355 1360

He Phe Ala His Lys Gin Gin Gin Gin Gin Gin Gin Gin Gly Pro Leu

1365 1370 1375

Gly Glu Ser Tyr Tyr His Gin Pro Asp Tyr Tyr Ser Trp Lys Gin Pro

1380 1385 1390

Ser Thr Gly Thr Gly Gly Leu Lys Thr Pro Arg Glu Tyr Tyr Asn Asn

1395 1400 1405

Ala Gly Ala Ala Ala Ser Ser Pro Gin Gin Ala His Glu Val Phe Tyr

1410 1415 1420

Trp Thr Gin Lys Pro Asn Ser Gly His Asn Gly Lys Lys Lys Arg Gly 1425 1430 1435 1440

Ala Gly Gly Val Pro Ala Ser Pro Ser Gly Ser Leu His Ser Arg Thr

1445 1450 1455

Ala Ala Ala Ser Gin Val Leu Phe Tyr Pro Ser Tyr Lys Lys Thr Lys

1460 1465 1470

Pro Gly Gin Pro Thr Gly Tyr Pro Gin Tyr Ala Glu Ala Leu Asp Pro

1475 1480 1485

Pro Leu Ala Thr Gly Asn Ala Ala Ala Tyr Tyr Gin Gin Gin Gin Gin

1490 1495 1500

Leu Arg Arg Gin Gin Leu His Gin Gin Gin Gin Gin Gin Gin Gin Gin 1505 1510 1515 1520

Gin Leu Ser Ser Asp Glu Glu Gin Ala Glu Gin His Ala His Leu Leu

1525 1530 1535

H s Leu Gin Arg Arg Ala Gly Ser Gin Gin Gin Leu Pro Ala Pro Pro

1540 1545 1550

Pro His Met Ala Gin Tyr Gin Gin Glu Phe Met Gin Arg Gin Tyr Arg

1555 1560 1565

Asn Lys His Ser Asn Cys Asp Leu Gly Met Gly Asp Ala Tyr Tyr Asn

1570 1575 1580

Gin Gly Ser Val Gly Gly Ala Asp Gly Gly Pro Val Tyr Glu Glu He 1585 1590 1595 1600

Leu Ser Asn Arg Asn Ser Asp Val Gin His Tyr Glu Val Gly Asp Phe

1605 1610 1615

Asp Val Asp Glu Val Tyr Asn Asn Ser Val Gly Thr Gly Val Phe Asn

1620 1625 1630

Asn Met Arg Ala Ala Val Ala Ala Gly Gly Ser Arg Tyr Gly Gly Gly

1635 1640 1645

Ser Leu Ser Gly Gly Ser Val Ser Ser Arg Ser Gin Gin Gin Gin Leu

1650 1655 1660

Lys Lys Gin Gin Gin Gin Gin Ser Leu Ala Gin Gin Arg Ser Ala Arg 1665 1670 1675 1680

Arg Cys Thr Ala Asp Asp Asp Asp Asp Glu Asp Glu Glu Glu Asp Glu

1685 1690 1695

Glu Ala Thr Ala Ala Glu Gin Leu His Asp Ser Val Cys Asp Glu Asp 1700 1705 1710

Glu Glu Glu Asp Glu Ser Asp Leu Glu Asp Asp Ala His Gly Leu Pro

1715 1720 1725

Pro Gin Ser Asp Glu Arg Met Arg Arg Leu Met Ala Met Gin Asp Glu

1730 1735 1740

Asp Phe Lys Arg Arg Phe Gin Arg Gin Leu Arg Lys His Gly Ala Pro 1745 1750 1755 1760

Leu Asp Tyr Gly Ala Leu Pro Pro Gly Ala Gly Pro Gin Pro Glu His

1765 1770 1775

Asn Gly Ala Val Phe Gly Val Ser Gly Gly Val Gly Glu Gly Ser Leu

1780 1785 1790

Arg Gly Ala Phe Arg Gin Gin Gin Gin Gin Ala Leu Asn Ala Lys Ser

1795 1800 1805

Pro Gly Gly Arg Leu Ala Val Asn Glu Leu Phe Gly His Gly Asn Ser

1810 1815 1820

Gly Pro Pro Leu Pro Pro Ala Asn Gin Thr Pro Ala Gin Lys Arg Gin 1825 1830 1835 1840

Gin Leu Gin Lys Leu Ser Pro Gin Ser Thr Thr Ser Ser Ser Ser His

1845 1850 1855

Thr Ser His Ser Asn Pro Asn Pro His Pro His Gin Leu Thr His Pro

1860 1865 1870

His Pro His Gin H s Pro Pro His His Gin Gin Arg His Leu Ser Ala

1875 1880 1885

Met Leu Asp Glu Asn Asn Thr Val Arg Cys Tyr Leu Glu Pro Leu Ala

1890 1895 1900

Lys 1905

<210> 10 <211> 4914 <212> DNA <213> Drosophila

<400> 10 cgcgggctcc atacgattcg tattagcccg caattgtata aaggttagtt agtttcttag 60 ctagttagtt ggacatttag aagtaggact ttttctgtgc gaaaatcagc agaagttgaa 120 ggaaaaccct cagtaattcc gccaaagttc gttgctggaa aaggactctt ttaaggtaat 180 ttcatgatat tgactcgttt cagttaagtc cctaaagcta atggcacact gaatacaatt 240 aggcattacg gctacgattg caattgcgtt tttttttttc gattgttaag tacacttgtt 300 tcggcatcgg gagaagacag caaagttgga aacctagttt ctggttccca tttttatttt 360 tttgtttttg aagacatgaa catgcgtatc acagtatttg gttgctgcgc gtttctctct 420 ctctctaact caaaaaaaaa gaatttatat aaaaatgcta aatatatata tgtatatatg 480 tgttatgtac gcaaaggcga cacacattaa gtcctaatgt ctaaaaggca agagcgatta 540 ttgaatttgg ttacaccaaa atggtaaaaa ggcaacgcaa ggggcaacta attaggagca 600 acattaagta cacacaggaa aataggatat gaagcccatc tagggcaatt acaaatacat 660 tgtagatgac ctatgacctc gcgataaagg cccaaactaa agcactaaga gcacatttcc 720 ggggttatat acacagtaca tagatcggtt taccccattg tgttctatgg acaggcaaag 780 caactaaaat cgaaataacg atatcgttat ctcacgatcg ttttatgaca aacaaattgg 840 accgtttccc cacccattta agttgctttg cctctttcga tacccgaaac cgcattaagt 900 tatagtagag gattgacttt ggcacagcag ctgctgcagg aacattgact ggaagcagga 960 agcatttcct gccctgaaat ggtacctaat ccaattccgt ctagagtagc gtctcattgc 1020 catactgctg caagtgggga tagtagctgc cgtgctggct gtacttttgc gaggcatagc 1080 tacctggcgg ataatacagc cgatgcgagg atgtggagtg atgctggtga ttgtggtggg 1140 gatggaactg atgatgctgc tgctgctggt gatgatgatg atgcggcgaa tggcgctgct 1200 ggtgatgcac gctcctgccc agcgaatagt tggacatctg attcagcgat atagagccgg 1260 taccaggcga agtcttcagt ttgtacggac ttggcggcaa cggaacactg gccatagaag 1320 ttcgcaccga atggtaggag accaccgtgc tattgcaagc cgcatgcgat ccacgcgagc 1380 tactatgccc gtccaggtgt ccagttgctg ctccggcaga cgtatgcttc accattttgc 1440 cattgctgac ttgcctcttg tagagagtgg aaatgcttgg tccaagtacc caggcaaaac 1500

20 agcaaatgcc cagcatcagt tccatgaagg cgcgcaacaa aaatggccaa agtggcgtat 1560 tggtatcacc cgatcccagc cagacatcga tgttggcaaa ctcgtaaatg acagccaaca 1620 gaagcatggc acatgcaagt ccatagatga aaaggaatat gccaatgccg gaactactgt 1680 gtgcgcttag ctgttgcagt tgctgttgca cgctgagtgc attgctattc ctcaggatct 1740 ccttggtgcg acagtgtacc aaatagccgg agatcagatt catcgagcca aagatccagt 1800 agcaaaaaac gggcgtagcc accaatatct gtagcgcctt atccgactga ttgcctacga 1860 aacaggcgcc tagaagagcg tatggttggg ttactctccg aattctccgg cggatctata 1920 gcatatctca ccaagcaact cgtcagcatc cacgaaacgg gcaacgatca ctgctgacgt 1980 ttgaaaggcc ggcaatcccc aggccacgaa gcacacaaag ttgttttgcg ttagatcctg 2040 ctgagccgtc ttggcactgt tcctcttcgc cggactgcct ccaaagttcg agggaatgac 2100 cacatggccc ttggagtccg gactgtgccg acgaatgtcg cggtgccagc ccaaacagag 2160 cacagcccac ctacaaatag gatatgggaa tatagtttct ataatattaa gtatatatta 2220 taatctaata ccaagcgcag gcggccattc caaaatagta gcgcataagg aagacactag 2280 cgcaggaggc attggacagt ccgtccacgg tgagtaggga ttcattgggc gcctggggat 2340 ccgtgccgca cgcagttccc gttcttccca ccataaagcg cactgcccag cccaaggtga 2400 ccatgttgtg gcaccaaatc agcggcgaca acaatctgga ccacttggcg ctggccaaac 2460 gactgccatc gctggccaaa agacacacgg tggctaccag ggccaaaccc aaagcggcat 2520 aggcccatgt ggagacccag atctctgcca gatgcttctc cgccggtgtg aacagtatgt 2580 ccgcctcgca gagtggtgca cagcgtccag atctgggtag ccttacgtac agatgcgatt 2640 tggccagtcc cgagcaatcc atgggcagtt taccgcccaa tccaccgggt attccttggc 2700 ccggtagccc atacaaatcc tgctcctgct gcggctgatg caattcaccg ggaccttcca 2760 tacacatcgt ctcgtggttg ttctctcgcg gaaatttatc gcagtcgaga gccggtggcc 2820 atggaaatcc gaatccctgc aaaactggat gacaacgtat tcgcacggac tcacagagac 2880 tccggcacgg accgatggca tggactggag ctttgggcgt gcacatgggc acgtaggcgg 2940 cgcacaggaa cagcttcaac tgggaactgc agtcgtattc gatcagtggt gcaaaggttt 3000 gcagtgtgta ctccacgtcc gtttgcattt cgttacccac cagatttggc atggaggtct 3060 cattgtagcc gatcttgcgg cacatctcaa tgcgaatggt ttcgcattgc cggaaggcgg 3120 ggatttctgg cggagaactg gaactggaac tggcactggg gttgccgctc gttgaggatt 3180 ttgagatgcg cggatgcagg aggatcacca ccaggagaca caatatgcag gttggcttca 3240 ttgcggctga tttgttgttc tttcgttccg aagaatacga attcgatacg tttcttcgct 3300 tggtgttccg atttccgttt ctctaaagga atcgaaatgt ggaaaagatc agatttcggg 3360 gttttcttcg cgctgggttc cctcttttct ttccaaagaa tccgaactat atgcagattc 3420 ttcgttcttc ggtggaacga acgctggaag gggtaacctg ttccaggtgc gttcgccctc 3480 tctcgctcgc accctctcac tcgttccaac aacttccagc tctccttctt tccagcttgt 3540 tattgttgct tttggcttgt caactcgtta actacctctt ttttttcggc gtcgttcttg 3600 ttatcgcttc tcctccttcc cccactcgtt cttcagcccc aaccactccc ctttctccac 3660 cgcacgccgc ccaacccgct gatcgacgtc gataaacggg tttttcctca gggattaacc 3720 cgaaaacgat ctagcaaacc atcgaatctt tcacacatct cagtgaacga atagtgtatt 3780 tgtttcgatg tgcttaaacg aatggcgcag tcagtttgta gccttagcga atgtattcta 3840 atctaattgg tattaacatc gaacgtttat atattttatt ttgttttcgt ggtaaaattc 3900 aacgcatact ggtcactctg agctagagat ggctctgcgt cacgtcacct cgcatcgatt 3960 gcaattgctc aacggatctg ctatcgatat caacaagtgt gttggttact aaatgctttt 4020 agatcaaaag gcgccccctg gcggagttat gcgtaatcaa agaacattga gaagggcgcg 4080 cttttcaaaa acaaatttgt ccaaataata agaaacattt aagcataata agaacataaa 4140 tgttcaataa attctatagg tgcagtaaaa tacgtgtttt gctagcacag ctattttaag 4200 ctgagaactt acaatatttt agtacattgt gcttaaggtt taaagataca tatattgaaa 4260 aagttctgga aatgcttttg aagaacaaag ctttaagagg cgcgctttcc gagtatgtga 4320 gcttttttca aatggcacac tttctgcgga atataaaata aaaaaaccta ataatatgcc 4380 gcaagaccac ttaagataaa atattaaaaa tattaaaatt gattatattt tgtgcaccaa 4440 aagtggcggt agcttaatat cgcaaaacca aattaatagc aattctgagc caaaccgcga 4500 ttgccatttc tgcatgttgg tcctccgtcc gtttcgccat ctccctttgg ccaccgcttg 4560 gcctctcttt cgcacacaca tggcaaacac aagccacgcc catgtatttc aacccccttg 4620 acaaaaatac gtaacatgcc acttttatgt atgaaacgtg acaaatacgc acatgtgtga 4680 gaaagagatc caccgagctg gcgagaaaga gagagagaga cgctggacgt ttatgtgttt 4740 ggcaggactc gcgtatgcag tgtgtgtgtg cgtgtgtgtg tgagtgtgtg tgagtgtttg 4800 ttgttggtta acgcacacgc gcagacgtag caacacatac acatatgtgg aaaggatatg 4860 tacatacata catacataca tacatatgcc cgctgacttt ttcgccactg ccaa 4914 <210> 11 <211> 2523 <212> DNA <213> Drosophila

<400> 11 gaccagtatg cgttgaattt taccacgaaa acaaaataaa atatataaac gttcgatgtt 60 aataccaatt agattagaat acattcgcta aggctacaaa ctgactgcgc cattcgttta 120 agcacatcga aacaaataca ctattcgttc actgagatgt gtgaaagatt cgatggtttg 180 ctagatcgtt ttcgggttaa tccctgagga aaaacccgtt tatcgacgtc gatcagcggg 240 ttgggcggcg tgcggtggag aaaggggagt ggttggggct gaagaacgag tgggggaagg 300 aggagaagcg ataacaagaa cgacgccgaa aaaaaagaga gaaacggaaa tcggaacacc 360 aagcgaagaa acgtatcgaa ttcgtattct tcggaacgaa agaacaacaa atcagccgca 420 atgaagccaa cctgcatatt gtgtctcctg gtggtgatcc tcctgcatcc gcgcatctca 480 aaatcctcaa cgagcggcaa ccccagtgcc agttccagtt ccagttctcc gccagaaatc 540 cccgccttcc ggcaatgcga aaccattcgc attgagatgt gccgcaagat cggctacaat 600 gagacctcca tgccaaatct ggtgggtaac gaaatgcaaa cggacgtgga gtacacactg 660 caaacctttg caccactgat cgaatacgac tgcagttccc agttgaagct gttcctgtgc 720 gccgcctacg tgcccatgtg cacgcccaaa gctccagtcc atgccatcgg tccgtgccgg 780 agtctctgtg agtccgtgcg aatacgttgt catccagttt tgcagggatt cggatttcca 840 tggccaccgg ctctcgactg cgataaattt ccgcgagaga acaaccacga gacgatgtgt 900 atggaaggtc ccggtgaatt gcatcagccg cagcaggagc aggatttgta tgggctaccg 960 ggccaaggaa tacccggtgg attgggcggt aaactgccca tggattgctc gggactggcc 1020 aaatcgcatc tgtacgtaag gctacccaga tctggacgct gtgcaccact ctgcgaggcg 1080 gacatactgt tcacaccggc ggagaagcat ctggcagaga tctgggtctc cacatgggcc 1140 tatgccgctt tgggtttggc cctggtagcc accgtgtgtc ttttggccag cgatggcagt 1200 cgtttggcca gcgccaagtg gtccagattg ttgtcgccgc tgatttggtg ccacaacatg 1260 gtcaccttgg gctgggcagt gcgctttatg gtgggaagaa cgggaactgc gtgcggcacg 1320 gatccccagg cgcccaatga atccctactc accgtggacg gactgtccaa tgcctcctgc 1380 gctagtgtct tccttatgcg ctactatttt ggaatggccg cctgcgcttg gtgggctgtg 1440 ctctgtttgg gctggcaccg cgacattcgt cggcacagtc cggactccaa gggccatgtg 1500 gtcattccct cgaactttgg aggcagtccg gcgaagagga acagtgccaa gacggctcag 1560 caggatctaa cgcaaaacaa ctttgtgtgc ttcgtggcct ggggattgcc ggcctttcaa 1620 acgtcagcag tgatcgttgc ccgtttcgtg gatgctgacg agttgcttgg caatcagtcg 1680 gataaggcgc tacagatatt ggtggctacg cccgtttttt gctactggat ctttggctcg 1740 atgaatctga tctccggcta tttggtacac tgtcgcacca aggagatcct gaggaatagc 1800 aatgcactca gcgtgcaaca gcaactgcaa cagctaagcg cacacagtag ttccggcatt 1860 ggcatattcc ttttcatcta tggacttgca tgtgccatgc ttctgttggc tgtcatttac 1920 gagtttgcca acatcgatgt ctggctggga tcgggtgata ccaatacgcc actttggcca 1980 tttttgttgc gcgccttcat ggaactgatg ctgggcattt gctgttttgc ctgggtactt 2040 ggaccaagca tttccactct ctacaagagg caagtcagca atggcaaaat ggtgaagcat 2100 acgtctgccg gagcagcaac tggacacctg gacgggcata gtagctcgcg tggatcgcat 2160 gcggcttgca atagcacggt ggtctcctac cattcggtgc gaacttctat ggccagtgtt 2220 ccgttgccgc caagtccgta caaactgaag acttcgcctg gtaccggctc tatatcgctg 2280 aatcagatgt ccaactattc gctgggcagg agcgtgcatc accagcagcg ccattcgccg 2340 catcatcatc atcaccagca gcagcagcat catcagttcc atccccacca caatcaccag 2400 catcactcca catcctcgca tcggctgtat tatccgccag gtagctatgc ctcgcaaaag 2460 tacagccagc acggcagcta ctatccccac ttgcagcagt atggcaatga gacgctactc 2520 tag 2523

<210> 12 <211> 700 <212> PRT <213> Drosophila

<400> 12

Met Lys Pro Thr Cys He Leu Cys Leu Leu Val Val He Leu Leu His

1 5 10 15

Pro Arg He Ser Lys Ser Ser Thr Ser Gly Asn Pro Ser Ala Ser Ser

22 20 25 30

Ser Ser Ser Ser Pro Pro Glu He Pro Ala Phe Arg Gin Cys Glu Thr

35 40 45

He Arg He Glu Met Cys Arg Lys He Gly Tyr Asn Glu Thr Ser Met

50 55 60

Pro Asn Leu Val Gly Asn Glu Met Gin Thr Asp Val Glu Tyr Thr Leu 65 70 75 80

Gin Thr Phe Ala Pro Leu He Glu Tyr Asp Cys Ser Ser Gin Leu Lys

85 90 95

Leu Phe Leu Cys Ala Ala Tyr Val Pro Met Cys Thr Pro Lys Ala Pro

100 105 110

Val His Ala He Gly Pro Cys Arg Ser Leu Cys Glu Ser Val Arg He

115 120 125

Arg Cys His Pro Val Leu Gin Gly Phe Gly Phe Pro Trp Pro Pro Ala

130 135 140

Leu Asp Cys Asp Lys Phe Pro Arg Glu Asn Asn His Glu Thr Met Cys 145 150 155 160

Met Glu Gly Pro Gly Glu Leu His Gin Pro Gin Gin Glu Gin Asp Leu

165 170 175

Tyr Gly Leu Pro Gly Gin Gly He Pro Gly Gly Leu Gly Gly Lys Leu

180 185 190

Pro Met Asp Cys Ser Gly Leu Ala Lys Ser His Leu Tyr Val Arg Leu

195 200 205

Pro Arg Ser Gly Arg Cys Ala Pro Leu Cys Glu Ala Asp He Leu Phe

210 215 220

Thr Pro Ala Glu Lys His Leu Ala Glu He Trp Val Ser Thr Trp Ala 225 230 235 240

Tyr Ala Ala Leu Gly Leu Ala Leu Val Ala Thr Val Cys Leu Leu Ala

245 250 255

Ser Asp Gly Ser Arg Leu Ala Ser Ala Lys Trp Ser Arg Leu Leu Ser

260 265 270

Pro Leu He Trp Cys His Asn Met Val Thr Leu Gly Trp Ala Val Arg

275 280 285

Phe Met Val Gly Arg Thr Gly Thr Ala Cys Gly Thr Asp Pro Gin Ala

290 295 300

Pro Asn Glu Ser Leu Leu Thr Val Asp Gly Leu Ser Asn Ala Ser Cys 305 310 315 320

Ala Ser Val Phe Leu Met Arg Tyr Tyr Phe Gly Met Ala Ala Cys Ala

325 330 335

Trp Trp Ala Val Leu Cys Leu Gly Trp His Arg Asp He Arg Arg His

340 345 350

Ser Pro Asp Ser Lys Gly His Val Val He Pro Ser Asn Phe Gly Gly

355 360 365

Ser Pro Ala Lys Arg Asn Ser Ala Lys Thr Ala Gin Gin Asp Leu Thr

370 375 380

Gin Asn Asn Phe Val Cys Phe Val Ala Trp Gly Leu Pro Ala Phe Gin 385 390 395 400

Thr Ser Ala Val He Val Ala Arg Phe Val Asp Ala Asp Glu Leu Leu

405 410 415

Gly Asn Gin Ser Asp Lys Ala Leu Gin He Leu Val Ala Thr Pro Val

420 425 430

Phe Cys Tyr Trp He Phe Gly Ser Met Asn Leu He Ser Gly Tyr Leu

435 440 445

Val His Cys Arg Thr Lys Glu He Leu Arg Asn Ser Asn Ala Leu Ser

450 455 460

Val Gin Gin Gin Leu Gin Gin Leu Ser Ala His Ser Ser Ser Gly He 465 470 475 480

Gly He Phe Leu Phe He Tyr Gly Leu Ala Cys Ala Met Leu Leu Leu

485 490 495

Ala Val He Tyr Glu Phe Ala Asn He Asp Val Trp Leu Gly Ser Gly

23 500 505 510

Asp Thr Asn Thr Pro Leu Trp Pro Phe Leu Leu Arg Ala Phe Met Glu 515 520 525

Leu Met Leu Gly He Cys Cys Phe Ala Trp Val Leu Gly Pro Ser He 530 535 540

Ser Thr Leu Tyr Lys Arg Gin Val Ser Asn Gly Lys Met Val Lys His

545 550 555 560

Thr Ser Ala Gly Ala Ala Thr Gly His Leu Asp Gly His Ser Ser Ser 565 570 575

Arg Gly Ser His Ala Ala Cys Asn Ser Thr Val Val Ser Tyr His Ser 580 585 590

Val Arg Thr Ser Met Ala Ser Val Pro Leu Pro Pro Ser Pro Tyr Lys 595 600 605

Leu Lys Thr Ser Pro Gly Thr Gly Ser He Ser Leu Asn Gin Met Ser 610 615 620

Asn Tyr Ser Leu Gly Arg Ser Val His His Gin Gin Arg His Ser Pro

625 630 635 640

His His His His His Gin Gin Gin Gin His His Gin Phe His Pro His 645 650 655

His Asn His Gin His His Ser Thr Ser Ser His Arg Leu Tyr Tyr Pro 660 665 670

Pro Gly Ser Tyr Ala Ser Gin Lys Tyr Ser Gin His Gly Ser Tyr Tyr 675 680 685

Pro His Leu Gin Gin Tyr Gly Asn Glu Thr Leu Leu 690 695 700

<210> 13 <211> 9795 <212> DNA <213> Drosophila

<400> 13 tcatactcac tggctgccaa cccctactct actctgacta ctttggttct ggttttggat 60 cttggctgat gctaggttct aactttaagt acgattctta gtattgctca ctggatacac 120 tgtagataca ccgcagatac agccgtcctg cggcggcaca acaacaagaa aacaaacgct 180 aatgcagcta cttacgacta ggaggatgat tagtggcaag gggttaagga gcgggttaat 240 cacaactggc tgggaaactg aaagtggccg acaagcgcat ctacttaacc tagatgatgg 300 tcctacgcgg cccagggtca atcacattgc ggagtaggtt ctacacagag agatgcgatt 360 tggtcaaaaa ctaagcttaa acgaccgcga tgttatctta tcaattaaaa cgaaaaaaat 420 ggaatcaaca tttttataga cccatttaaa gagctatcat cttttttcac cgaaatactt 480 aaggaaataa tatgcatgct tagtaaagga acactacact aggtcttaag aaatgattat 540 caagaagtaa acatttggca ccccgaggcg aatactgata ctggtagttt ttagaaaact 600 ttgctgatac cgaaaactcg cgaattaaga taaattctaa cattgcacaa atttcttagt 660 ttacattgta aattttgtct acttctaggc agagcacaat gtgcctgcaa ttttctccgt 720 gttgttgatt ctgctaagtt caggaaaatg actagctatg tgaacttgac ttgaggaggg 780 agggggaggt tcgtatcgtg acttatctag cgttttaccc taatgcattt gattgcttta 840 agctgatgat tggtcagttg cacacgcgct attctggggc agattttgtg ggcgtgtcgt 900 aaaataattg cttggtgttt cgcttctaat tgacgaggac ttggacttgg atttgaagtg 960 tggaccgtgt acagagtgga caatggacag ggcatcttat ttattcggtg ccattcgcag 1020 gcgcctgctg ctcctcttcc tgggaatcgc cgagggaaag cctcgacttg cccgctgttt 1080 ccatcgattt ccaggtgcct ccactggtgg cctgctgcag cgaaatgcga ggtatggact 1140 tgcagctgcc caagatagag gtgctatctc cgggacggtc ctcggattcg gccagggcgc 1200 tgagactgca agtgggcggc aggatgcggt gtggaaagcg tggcgaaccc cttacccttt 1260 cccttaaact gggtggctgc tgcaccaccg aaggtctccg gttgctgggc aattggaagt 1320 tcaccttggt ctccagcagt ttcacatact ttccacccaa cgtttggtcc ccctgttcac 1380 cgccagaaat agtggggata ggcaggaaat tcggatcctt ggtaaggtga tccaggtgag 1440 taccgctttt ggtcaatgaa cccctatgga tgggctttag gtggttacca ttcgggtggg 1500 aggacgcctc tgagggaatg gaatcctgat ttggattatt gtatatggca ttgcaggacg 1560 ccgtttgaga ggagggaatc aggcgggtga acagtcccat gtgcgattta aaggccgcct 1620

24 tcagaccctt ttggtccgcc aagctggcgg tggatccctt gttgctcgaa gtggtgcgag 1680 aaaatatccc tcgtaatcgg tttatcaagc ccgtcttagc ctccgtggcc tgctggtggg 1740 ctaaacggag gttaatcaag tcctgtgcag gcaggcaggc ctcctctaat tggggctggg 1800 aggcaaaggt aacagaacgc ctcatcggga tctgcatgta ctctgctgac ggccaactgg 1860 cccgtggaat cacaggaggc agcacggaaa gcaggagatt gggcagtatt cccgagatac 1920 ttggagttct gtttttactt gcagccggag tctgcgagat gccactggtt accgtcagtt 1980 ctggctttag atgacctccc ccagttaaga gtgatgtgga cgacgaagtt gtggtggagg 2040 tggtggttag tcccgactcg agtagcctct ccagctttcg aatctcggcg tccagagcct 2100 ggatttcctt cttatagacc ctgttttgca cctccactcg atactgcagt tctcggcgat 2160 catcgaccac gaatcggcgt gtgttgcact ccatcttaag gcccatactg tggataaccg 2220 gatcgataat atcgtctgag ggagaaggag agttcccaaa ggattaggac acaactttat 2280 aaaggttcta gaaattagga gactagaact taaaagtatt tcctaagtga gcaagatctt 2340 attgcacctt caagcgctac ttacttcttg cccaaatatc atggagtttt gggatgaaaa 2400 gcagacaaag ggttgcagtg gtgctggtta aaatcagagc tgtgattgtg atgaaggcca 2460 gggtgactcg ctccgaaatc aagttggcca gcaccacgac gatggcgctg gtgatgacca 2520 cactgtatac agacactccg atgtactgcg agtcattgag agcaggtatt tttacgtggc 2580 gcgtctccca ggccatatag acacccacca caagaagaag gcctttgtag gcgtacagga 2640 cactcaacca cgtttgcgtg tgctgcgaac ggcaaacttc aacctaaaat agatagatag 2700 atagatattc atagattcta aatgaattaa tactttttca acataattaa aagtaatctg 2760 ataatttgaa gcatattaat atttttctta cctgaggctg gtaaacgaca cttctatcag 2820 tcgcactgat ctcgagcgtc aggttgtgaa gatggcgctc cattggatcg gtgaccaccc 2880 aaagggttac gagcagcgca tccaccagaa gcaatccgcc gacgagcaag atcagttgaa 2940 tgtcctgcag catcttgtcc ttgaaaacgc tgccggtacg agtgaatatc cgatgcactc 3000 tgtaggtctt ggcaaacatc gatccaaagg ccaacgagaa tccggcggag agcagataga 3060 cgcgggcctg gtgagcatga taagcggatg acggggaagt tcaggttagg gagaaagtac 3120 tgtagtagca gcagcaaagt aacacactaa gtgtcatgtc aggcagaccc aaagaaaaca 3180 agccggcggc aacaatgggg gaaacaagtc atcaatggac cacaattctc agagtgcttg 3240 agactttgtt gtgcgtttca aatttatgca aataaaggaa tatcacaaaa gttgtaaatt 3300 tccgtgtcat gtgtttgcat ttccctgcca caagcctcaa caaaacaaaa acaagcaggc 3360 aactggaaaa gcggaacgac agtagaagtg gttacagaaa cagaaacaac agcgaccagc 3420 aaatttccca ggagtggcgt tcgaggcagt tgttaagggg gtcaaagtgg aaaggcgcag 3480 atcgggatag aagaaagctc gtcaaacttg acttgacttc tggcttaaag agcagcagat 3540 ttgcagcgaa accgaacggc tatttatagc cagcaggggc agtcgtgtat cttgaaaaga 3600 cacgcggaat aatcaatatt cagtttatat aatccacttt aaaataatag aaattaacaa 3660 aaaattgcca caattatcag taatttttat acttcgcagg ctattttatc gccatcttcg 3720 tgtatacgaa tacgacaatt agttcaagca atatttcttt cagtgaataa ataaagcaaa 3780 cacatgagcg cgactcgaaa gttaccagcc tgaaactgaa agtcatattt gatgaggacc 3840 ccacatgctt gcttacacac agaagcccgt caaagtcaaa caaagacggc tgagaggaaa 3900 ggcggatgag aatgcggatt cggataggaa tggcgatagg gatggggatg tcggagccga 3960 aggataacaa ctcaccgtgc agaccgttgc gaaagagtcc tccgccgagg gcagcgtcga 4020 gtggtccaag cccaaaagga tgacggtggc gtacacaaag atgcagccca ctgcggtgat 4080 gttgctcagc ttcgggctgg aaagtttaat tgccctgtgg agtgagaagg gggatggtca 4140 tggttataag ctgaggcgcc gcaatccttt gcagagaaag tgcagagtaa ccgtagaatg 4200 cgaaacatat atacgaactc aactaacgat gggtcagaaa tacagctgga aagccaagca 4260 attacttcac ttcaaaaacc gaaacaagtc acatgtgtaa tgggttcaat gggttgagca 4320 ccgaaagcag ttaactcatc atggaatata aagaaacagc ccgcacaaat tctcttttat 4380 atggccacta aatattttat agtcgtttaa tgaaaaataa tatattcaaa caatcagggc 4440 ccataaaaag agtaagccaa taatttatgt acttatcgcc ttacttcagc ttccgaaagt 4500 gcagattgaa cgccaggaag gcgatggcca gagcgattcc cacgctggag agggtggcga 4560 tggtgtagaa ggccagtgga gcgatggtcg ccacccgcag cttgaacacc cgcttggcga 4620 tgggtacctg cccgctgtgc cacttcaccg gccggcagcg gggacaccgg aagtccaggg 4680 catccgtggc cggatagtag agggccaccg gttccagcaa accgcgctgg atttgataga 4740 aggcagtggt gccaacgcga tctgggccgc tgaaggaaac ggggccctac caaaaagaga 4800 aatactcgtg atgaactaga tttaagaacc ttaggatcaa agttaaatgg gttggatgat 4860 ttcagttgaa agagataact caccgacact cccaggaagt ggagcttgcc catttgctgc 4920 aggaactccc aggccatgtc gctgcgggtg taatcgaatc cgtccagctt cgactgctcc 4980 tcgttccgcc gccagtgctc ctcagcggct ctcaaggcca gggcgatggc ccacacggcg 5040 tcgtaggttt gcggcgcgta ctgcgagatc gcctccggaa agaggtgccc tccgctggtg 5100 cctcccacgc cccttctcct ccgccgacga gagtcagatt gcgttgcagc gatactgatc 5160 ctggaaccat aaccggagcc aaatccatcc tggccgtgga actgggcgga ttgcttgcgc 5220

25 agctgggagt tgaacatgtg attgttctgc gaagtggaaa cgcgattaaa caagcctcga 5280 atgccgcaga aatgtcgcca gtaatgagat tgcctatggc agctaccact cctgccccaa 5340 tttcatgacc agcactaaaa gagccataaa aacgcgtctg cgatggtgaa tgcgaatgcg 5400 atgacaggcc ggacttaggg ggcttcgcac ttggcaatca ccatcgccat cgccattgct 5460 gaaaccatcg cgaaacgcaa tcgcagcctc gggattgtct aatcaaataa atcatttcat 5520 ttcggacacg cacagcaaga cggacaagac aggacaacga gaaggacaag atagtcgtct 5580 ctgaataaaa aaaaaaaaaa aaaaaaacgg ggaataaaag tttcggcaat tctggaaaat 5640 gttgcttgaa gctgcctttg agagttgggt tcaatccaat ttggatcccg aaatttatat 5700 gcatgtataa cttaacaaca atctattctt gaaattcatc tttacgttaa tctcatactg 5760 tcatgaaatt aatttattta ttttcccttt aatattgaat gatattttct cgcagtgcac 5820 ctcctcaact taccagtcca ctatagctga cgttatttcc aacgatgctg ttgtgcgttg 5880 agaccacgat gaggttctcg acggccagct gcagttcgtg gttagagcag gcggtgcgct 5940 ggtccggcca ccacggagcc cccatgctct cgtggaggat ccaggcgtag tccgccccga 6000 acattcgaag cctgtaggcc tcgcacagga tctggggggc cagctcctgc gagaagctgc 6060 cgatgatgat gcgcgtgtcc gtctcctgtg gcgatacgaa cgaaacggaa cggcatgtgc 6120 ccatttgtca tttgtcatcc ttcgattagc acaagtgcca atccacactc aaaaaaaatg 6180 ggtaacaatc atcatgctga tagagggtct ctaggcgatg tggtctgcta atgaaacatt 6240 tatccatgcg gactggacga acaaaaaact tgaagataaa ctcagagaaa taagttaacg 6300 taaaaaacgt aattataatc atacatatga accttttttt taaaaactta ctaaattaag 6360 ttgccaggca aataaattgg tctatttaaa tattccccaa atacgttcat tttcatattt 6420 gttcatgcat aagcttttaa tataaacaga acagcgctag caccatttta atttaaacat 6480 tttcgaaaat tgaaatttag ttaaatttaa tgttggtttt tcaaacaaat attcataaat 6540 gtttacgttt atacgtttgc gtatacgagt ataaaataaa acgaaaatgt gtatttaaat 6600 ggccatttgt tgctcaccct aagtagcagc agctgctcct tgaagtcggt ggccgcaaag 6660 gtgatggtgg cggcacagga tatgttggcc gcctccagtt cggtgaccag gttgttcacc 6720 gccagcgagt gaacctcctc gttctgcgag aaagtggtca ccgtgcccca gccaaacttc 6780 cgaatgaaag cgatgcgcgc cggattgtgt gaggagtccg gggccaccgt cctgtagaag 6840 taggggaact cccgcctgtc gctcaacgcc ggcgatgtgg aaccgaagga tacctttcat 6900 cgaacgaaat cgttagacta tctctaccgt acatggggtc gcttaaaatg caagacacgc 6960 atcaagaaat ccagccctct aggtcatgtg tcttcccagt ttccccactc atttaacaca 7020 cgcaccgccg aaatgaaact tcaaaggcca aatgcaaatg ctctaagtga atttgtggac 7080 ctcataattt gtgggctgtg gaaatgttta tggctcaaag gtttatgggg tgctggaatc 7140 ggctggattc cgcagcattt atgctaatcg agctacgcac gtgagttgat tagatttttg 7200 agaaattgcc cgatacgagg agttggttgg atgaaccgag cgagctggat tatttgcatt 7260 ttaatcagtc gcagatgact cacctgcacg atgttccagt agggcaccac cttcgccagg 7320 ctctcggtga cctccgagca ggccgatccc agcagcatca ccatcctcgt cgagggctgt 7380 gtgtagatgg cgtggaagaa gcgatccacg cccactccag gatcacactg attgtcggag 7440 aagaaatgtg tgaagaaacg gaggagcaaa ggacaccaca tcagagatga gtaatagagg 7500 gggcagggaa aatagcagtg gcagaggccg ttgctcgctg actcgtttcg acgcaataaa 7560 aaggcaacat gatggcgcaa taaacatttt taaaatgtcg acttttagag aggcacagcc 7620 ggagatgcgg ctccagatat gacagtctgt ttaaggtcga tgtgcatatg catacactta 7680 aaaaaatcgt ttgaaaacct agttcactaa gtgctgacat cacagtcgag gtattacgta 7740 ttgacggttt aatttatcag aaactaaact actattatgc attttctttt ttttaccatc 7800 aattaattgt agctttaata cactactgca ccaagttaaa aatgattgca ggtaaatagt 7860 ttacattgtt ggtaacttag tcagtggcat tgcttttctt cagtgacagt gttctgtaca 7920 tttgcgtgcc ccatcaaaac cggcaacgac tcatcgcaat aaaagcgcga aagacggaag 7980 gttgatgaca tatttgcctc tcttttaggg ccacagccgc agctgctatc cgcactgttc 8040 ttgttgttgc agattttctt attaagtttt aatgttgcac gcgctactga atgaaaattc 8100 aatttcgtaa tggaacagcg acgcctagaa gtggcgccca acgtggggca tacggttacg 8160 ccacgtagaa atgacattct cacctgagta tcgttggtca cgagctcgag ggtgtagccc 8220 ggcagcaggc gcttgcggtt gatgtgctcc acggccatgg tggcagctcc caattcgctc 8280 agaccatccg gacgtggtcc ccgcgatgtg gacagctcaa agagtccgag cagcacgatt 8340 ttgccatgat tgcgctgcat ttcggccggc gacatgcggc gttcgctttc gaacacctgg 8400 ttgaccttca agtatcgctg cctggggggc agattgagga ggtggtgggc gtgggaggca 8460 ttggtgcttc cgggcagatt gctgtgcgaa ttgaggcgct gctgccggcg tttgactttc 8520 gtccgtttgt acttccaatc ggagcgcggt ggaatcggag tcccccctgc agtcacagtc 8580 gatgccgatt ctccgggtgg cgagctggat gggctggatg tgctaattga ggcagcacct 8640 ggcctaattg cctcgtagcc cagggcctgc agctcggctg atgactccat ggcagccgct 8700 gccgacgttg cccaggcaag ggccaggact agcctcagtc ccacggccgg ccatggaccg 8760 tatctggtcc cttggaccgg ttgaattatg cgcatcccgt cggcaatggc caatggccca 8820

26 ttaatcacca aggcatttga atcgtcggct atcagaggct gcagcaacaa acaaacacga 8880 gccacacagc acaggacacc ggaatatata tcgccttttt atgcactctg ccgacaggat 8940 acgcttatcg tttctcttcc gacgagcggc tcttccttct gctccctcct cttgtatcgg 9000 cgtcaatttt atcgcctttt tattggcctc acttttgctc gcattttgta tctttttgca 9060 cattcactct gcacagcagt cgaccataaa agtatgcaat gcaaaggact ttctcgatag 9120 gtccgattga caggattggg taacacggga aaaaactaca cgccattcgc taactttcag 9180 tcacttttcg tagaaaaaaa tgcttatttt tattatgcac tgtttattaa ggattaacac 9240 aatttaggtg aatatttatt agtattttgc tgtagtatgt gattttatta aaatgtaatt 9300 tgaatctaca tatgtatata tatgtatata tgtgaaaaca ttgatttttt catgagaatg 9360 tgaaagggaa tgttaatgga aataccgaaa caaatgtcta gggaggcata aaaaggcatt 9420 tcacaccaat ttggcagtcg aaaggattat gacgaaggct tcgatgatat ggacacaccg 9480 cgccgctcac gtctcgtccc atgacttgtt atgtgcctgc cacttggcca ttatttttta 9540 tgctaatggc caaacatttt gcgctttcat tgcgggcttt tggactactt tttgtcgagt 9600 ctcacgcgcc acagatttct gtggcgaacg tttttctctg tatgcgcgcg tatgcataat 9660 tgtttcaaga ttaccaactt gcagtccctt tgccgctttc ccgcttttcc accgcccact 9720 tgcctgcacc taagcccact tcatagacgc tttccttcgc gctttctgct tttcccacag 9780 cacgcttttc gctgt 9795

<210> 14 <211> 3918 <212> DNA <213> Drosophila

<400> 14 atgcgcataa ttcaaccggt ccaagggacc agatacggtc catggccggc cgtgggactg 60 aggctagtcc tggcccttgc ctgggcaacg tcggcagcgg ctgccatgga gtcatcagcc 120 gagctgcagg ccctgggcta cgaggcaatt aggccaggtg ctgcctcaat tagcacatcc 180 agcccatcca gctcgccacc cggagaatcg gcatcgactg tgactgcagg ggggactccg 240 attccaccgc gctccgattg gaagtacaaa cggacgaaag tcaaacgccg gcagcagcgc 300 ctcaattcgc acagcaatct gcccggaagc accaatgcct cccacgccca ccacctcctc 360 aatctgcccc ccaggcagcg atacttgaag gtcaaccagg tgttcgaaag cgaacgccgc 420 atgtcgccgg ccgaaatgca gcgcaatcat ggcaaaatcg tgctgctcgg actctttgag 480 ctgtccacat cgcggggacc acgtccggat ggtctgagcg aattgggagc tgccaccatg 540 gccgtggagc acatcaaccg caagcgcctg ctgccgggct acaccctcga gctcgtgacc 600 aacgatactc agtgtgatcc tggagtgggc gtggatcgct tcttccacgc catctacaca 660 cagccctcga cgaggatggt gatgctgctg ggatcggcct gctcggaggt caccgagagc 720 ctggcgaagg tggtgcccta ctggaacatc gtgcaggtat ccttcggttc cacatcgccg 780 gcgttgagcg acaggcggga gttcccctac ttctacagga cggtggcccc ggactcctca 840 cacaatccgg cgcgcatcgc tttcattcgg aagtttggct ggggcacggt gaccactttc 900 tcgcagaacg aggaggttca ctcgctggcg gtgaacaacc tggtcaccga actggaggcg 960 gccaacatat cctgtgccgc caccatcacc tttgcggcca ccgacttcaa ggagcagctg 1020 ctgctactta gggagacgga cacgcgcatc atcatcggca gcttctcgca ggagctggcc 1080 ccccagatcc tgtgcgaggc ctacaggctt cgaatgttcg gggcggacta cgcctggatc 1140 ctccacgaga gcatgggggc tccgtggtgg ccggaccagc gcaccgcctg ctctaaccac 1200 gaactgcagc tggccgtcga gaacctcatc gtggtctcaa cgcacaacag catcgttgga 1260 aataacgtca gctatagtgg actgaacaat cacatgttca actcccagct gcgcaagcaa 1320 tccgcccagt tccacggcca ggatggattt ggctccggtt atggttccag gatcagtatc 1380 gctgcaacgc aatctgactc tcgtcggcgg aggagaaggg gcgtgggagg caccagcgga 1440 gggcacctct ttccggaggc gatctcgcag tacgcgccgc aaacctacga cgccgtgtgg 1500 gccatcgccc tggccttgag agccgctgag gagcactggc ggcggaacga ggagcagtcg 1560 aagctggacg gattcgatta cacccgcagc gacatggcct gggagttcct gcagcaaatg 1620 ggcaagctcc acttcctggg agtgtcgggc cccgtttcct tcagcggccc agatcgcgtt 1680 ggcaccactg ccttctatca aatccagcgc ggtttgctgg aaccggtggc cctctactat 1740 ccggccacgg atgccctgga cttccggtgt ccccgctgcc ggccggtgaa gtggcacagc 1800 gggcaggtac ccatcgccaa gcgggtgttc aagctgcggg tggcgaccat cgctccactg 1860 gccttctaca ccatcgccac cctctccagc gtgggaatcg ctctggccat cgccttcctg 1920 gcgttcaatc tgcactttcg gaagctgaag gcaattaaac tttccagccc gaagctgagc 1980 aacatcaccg cagtgggctg catctttgtg tacgccaccg tcatcctttt gggcttggac 2040

27 cactcgacgc tgccctcggc ggaggactct tttegcaacgg tctgcaciggc ccgcigtctat 2100 ctgctctccg ccgg;attctc gttggccttt gg;atcg;atgt ttgc :caa<gac ctacagagtg 2160 catcggatat tcactcgtac cggcagcgtt ttcaaggaca agal :gctιgca ggac,attcaa 2220 ctgatcttgc tcgtt =ggcgg attgcttctg gtggatgcgc tgctcgtaac cctttgggtg 2280 gtcaccgatc caattggagcg ccatcttcac aacctgacgc tcgagatcag tgcg;actgat 2340 agaagtgtcg tttac :cagcc tcaggttgaa gtttgccgtt cgcagcacac gcaaacgtgg 2400 ttgagtgtcc tgtacgccta caaaggcctt cttcttgtgg tgggtgtieta tatggcctgg 2460 gagacgcgcc acgt;aaaaat acctgctctc aatgactcgc agtacatcgg agtgtctgta 2520 tacagtgtgg tcatcaccag cgccatcgtc gtggtgctgg ccaacttigat ttcggagcga 2580 gtcaccctgg ccttcatcac aatcacagct ctgattttaa ccagcaccac tgcaaccctt 2640 tgtctgcttt tcatt :ccaaa actccatgat atttgggcaa gaaacga tat tatctgatccg 2700 gttatccaca gtat(gggcct taagatggag tgcaacacac gccgattcgt ggtctgatgat 2760 cgccgagaac tgcacgtatcg agtggaggtg caaaacaggg tctataatgaa ggaaatccag 2820 gctctggacg ccga<gattcg aaagctggag aggctactcg agtcggg;act aaccaccacc 2880 tccaccacaa cttctgtcgtc cacatcactc ttaactgggg gaggtcatct aaagtccagaa 2940 ctgacggtaa ccagtggcat ctcgcagact ccggctgcaa gtaaaaacag aacticcaagt 3000 atctcgggaa tactgcccaa tctcctgctt tccgtgctgc ctcctgtgat tccacgggcc 3060 agttggccgt cagcagagta catgcagatc ccgatgaggc gttctgt'tac Cttttgcctcc 3120 cagccccaat tagacggaggc ctgcctgcct gcacaggact tgattaacct ccgt'ttagcc 3180 caccagcagg ccactggaggc taagacgggc ttgataaacc gattacg;agg gata'ttttct 3240 cgcaccactt cgagt :aacaa gggatccacc gccagcttgg cggaccaaaa gggttctgaag 3300 gcggccttta aatcgcacat gggactgttc acccgcctga ttccctcctc tcaaacggcg 3360 tcctgcaatg ccat;atacaa taatccaaat caggattcca ttccctcaga ggcgtcctcc 3420 cacccgaatg gtaaccacct aaagcccatc cataggggtt cattgaccaa aagctggtact 3480 cacctggatc accttaccaa ggatccgaat ttcctgccta tccccadtat ttct<ggcggt 3540 gaacaggggg accaaacgtt gggtggaaag tatgtgaaac tgctggagac caaggtgaac 3600 ttccaattgc ccageeaaccg gagaccttcg gtggtgcagc agccacccag tttaagggaa 3660 agggtaaggg gttcgccacg ctttccacac cgcatcctgc cgcccacttg cagtctcagc 3720 gccctggccg aatccgagga ccgtcccgga gatagcacct ctatcttggg cagctgcaag 3780 tccatacctc gcatttcgct gcagcaggcc accagtggag gcacctggaa atcg;atggaa 3840 acagcgggca agtc<gaggct ttccctcggc gattcccagg aagaggatgca gcaggcgcct 3900 gcgaatggca ccga;ataa 3918

<210> 15

<211> 1305

<212> PRT

<213> Drosophil;a

<400> 15

Met Arg He He Gin Pro Val Gin ( 31y Thr Arg Tyr Gly Pro Trp Pro

1 5 10 15

Ala Val Gly Leu Arg Leu Val Leu Ala Leu Ala Trp Ala Thr Ser Ala

20 : 25 30

Ala Ala Ala Met Glu Ser Ser Ala ( 31u Leu Gin Ala Leu Gly Tyr Glu

35 40 45

Ala He Arg Pro Gly Ala Ala Ser : He Ser Thr Ser Ser Pro Ser Ser

50 55 60

Ser Pro Pro Gly Glu Ser Ala Ser :rhr Val Thr Ala Gly Gly Thr Pro

65 70 75 80

He Pro Pro Arg Ser Asp Trp Lys 'ryr Lys Arg Thr Lys Val . Lys Arg

85 90 95

Arg Gin Gin Arg Leu Asn Ser His ! Ser Asn Leu Pro Gly Ser Thr Asn

100 : 105 πc )

Ala Ser His Ala His His Leu Leu Asn Leu Pro Pro Arg Gin Arg Tyr

115 120 125

Leu Lys Val Asn Gin Val Phe Glu ! Ser Glu Arg Arg Met Ser Pro Ala

130 135 140

Glu Met Gin Arg Asn His Gly Lys I He Val Leu Leu Gly Lei:l Phe Glu

145 150 155 160

Leu Ser Thr Ser Arg Gly Pro Arg ] Pro Asp Gly Leu Ser Glui Leu Gly

28 165 170 175

Ala Ala Thr Met Ala Val Glu His He Asn Arg Lys Arg Leu Leu Pro

180 185 190

Gly Tyr Thr Leu Glu Leu Val Thr Asn Asp Thr Gin Cys Asp Pro Gly

195 200 205

Val Gly Val Asp Arg Phe Phe His Ala He Tyr Thr Gin Pro Ser Thr

210 215 220

Arg Met Val Met Leu Leu Gly Ser Ala Cys Ser Glu Val Thr Glu Ser 225 230 235 240

Leu Ala Lys Val Val Pro Tyr Trp Asn He Val Gin Val Ser Phe Gly

245 250 255

Ser Thr Ser Pro Ala Leu Ser Asp Arg Arg Glu Phe Pro Tyr Phe Tyr

260 265 270

Arg Thr Val Ala Pro Asp Ser Ser His Asn Pro Ala Arg He Ala Phe

275 280 285

He Arg Lys Phe Gly Trp Gly Thr Val Thr Thr Phe Ser Gin Asn Glu

290 295 300

Glu Val His Ser Leu Ala Val Asn Asn Leu Val Thr Glu Leu Glu Ala 305 310 315 320

Ala Asn He Ser Cys Ala Ala Thr He Thr Phe Ala Ala Thr Asp Phe

325 330 335

Lys Glu Gin Leu Leu Leu Leu Arg Glu Thr Asp Thr Arg He He He

340 345 350

Gly Ser Phe Ser Gin Glu Leu Ala Pro Gin He Leu Cys Glu Ala Tyr

355 360 365

Arg Leu Arg Met Phe Gly Ala Asp Tyr Ala Trp He Leu His Glu Ser

370 375 380

Met Gly Ala Pro Trp Trp Pro Asp Gin Arg Thr Ala Cys Ser Asn His 385 390 395 400

Glu Leu Gin Leu Ala Val Glu Asn Leu He Val Val Ser Thr His Asn

405 410 415

Ser He Val Gly Asn Asn Val Ser Tyr Ser Gly Leu Asn Asn His Met

420 425 430

Phe Asn Ser Gin Leu Arg Lys Gin Ser Ala Gin Phe His Gly Gin Asp

435 440 445

Gly Phe Gly Ser Gly Tyr Gly Ser Arg He Ser He Ala Ala Thr Gin

450 455 460

Ser Asp Ser Arg Arg Arg Arg Arg Arg Gly Val Gly Gly Thr Ser Gly 465 470 475 480

Gly His Leu Phe Pro Glu Ala He Ser Gin Tyr Ala Pro Gin Thr Tyr

485 490 495

Asp Ala Val Trp Ala He Ala Leu Ala Leu Arg Ala Ala Glu Glu His

500 505 510

Trp Arg Arg Asn Glu Glu Gin Ser Lys Leu Asp Gly Phe Asp Tyr Thr

515 520 525

Arg Ser Asp Met Ala Trp Glu Phe Leu Gin Gin Met Gly Lys Leu His

530 535 540

Phe Leu Gly Val Ser Gly Pro Val Ser Phe Ser Gly Pro Asp Arg Val 545 550 555 560

Gly Thr Thr Ala Phe Tyr Gin He Gin Arg Gly Leu Leu Glu Pro Val

565 570 575

Ala Leu Tyr Tyr Pro Ala Thr Asp Ala Leu Asp Phe Arg Cys Pro Arg

580 585 590

Cys Arg Pro Val Lys Trp His Ser Gly Gin Val Pro He Ala Lys Arg

595 600 605

Val Phe Lys Leu Arg Val Ala Thr He Ala Pro Leu Ala Phe Tyr Thr

610 615 620

He Ala Thr Leu Ser Ser Val Gly He Ala Leu Ala He Ala Phe Leu 625 630 635 640

Ala Phe Asn Leu His Phe Arg Lys Leu Lys Ala He Lys Leu Ser Ser

29 645 650 655

Pro Lys Leu Ser Asn He Thr Ala Val Gly Cys He Phe Val Tyr Ala

660 665 670

Thr Val He Leu Leu Gly Leu Asp His Ser Thr Leu Pro Ser Ala Glu

675 680 685

Asp Ser Phe Ala Thr Val Cys Thr Ala Arg Val Tyr Leu Leu Ser Ala

690 695 700

Gly Phe Ser Leu Ala Phe Gly Ser Met Phe Ala Lys Thr Tyr Arg Val 705 710 715 720

His Arg He Phe Thr Arg Thr Gly Ser Val Phe Lys Asp Lys Met Leu

725 730 735

Gin Asp He Gin Leu He Leu Leu Val Gly Gly Leu Leu Leu Val Asp

740 745 750

Ala Leu Leu Val Thr Leu Trp Val Val Thr Asp Pro Met Glu Arg His

755 760 765

Leu His Asn Leu Thr Leu Glu He Ser Ala Thr Asp Arg Ser Val Val

770 775 780

Tyr Gin Pro Gin Val Glu Val Cys Arg Ser Gin His Thr Gin Thr Trp 785 790 795 800

Leu Ser Val Leu Tyr Ala Tyr Lys Gly Leu Leu Leu Val Val Gly Val

805 810 815

Tyr Met Ala Trp Glu Thr Arg His Val Lys He Pro Ala Leu Asn Asp

820 825 830

Ser Gin Tyr He Gly Val Ser Val Tyr Ser Val Val He Thr Ser Ala

835 840 845

He Val Val Val Leu Ala Asn Leu He Ser Glu Arg Val Thr Leu Ala

850 855 860

Phe He Thr He Thr Ala Leu He Leu Thr Ser Thr Thr Ala Thr Leu 865 870 875 880

Cys Leu Leu Phe He Pro Lys Leu His Asp He Trp Ala Arg Asn Asp

885 890 895

He He Asp Pro Val He His Ser Met Gly Leu Lys Met Glu Cys Asn

900 905 910

Thr Arg Arg Phe Val Val Asp Asp Arg Arg Glu Leu Gin Tyr Arg Val

915 920 925

Glu Val Gin Asn Arg Val Tyr Lys Lys Glu He Gin Ala Leu Asp Ala

930 935 940

Glu He Arg Lys Leu Glu Arg Leu Leu Glu Ser Gly Leu Thr Thr Thr 945 950 955 960

Ser Thr Thr Thr Ser Ser Ser Thr Ser Leu Leu Thr Gly Gly Gly His

965 970 975

Leu Lys Pro Glu Leu Thr Val Thr Ser Gly He Ser Gin Thr Pro Ala

980 985 990

Ala Ser Lys Asn Arg Thr Pro Ser He Ser Gly He Leu Pro Asn Leu

995 1000 1005

Leu Leu Ser Val Leu Pro Pro Val He Pro Arg Ala Ser Trp Pro Ser

1010 1015 1020

Ala Glu Tyr Met Gin He Pro Met Arg Arg Ser Val Thr Phe Ala Ser 1025 1030 1035 1040

Gin Pro Gin Leu Glu Glu Ala Cys Leu Pro Ala Gin Asp Leu He Asn

1045 1050 1055

Leu Arg Leu Ala His Gin Gin Ala Thr Glu Ala Lys Thr Gly Leu He

1060 1065 1070

Asn Arg Leu Arg Gly He Phe Ser Arg Thr Thr Ser Ser Asn Lys Gly

1075 1080 1085

Ser Thr Ala Ser Leu Ala Asp Gin Lys Gly Leu Lys Ala Ala Phe Lys

1090 1095 1100

Ser His Met Gly Leu Phe Thr Arg Leu He Pro Ser Ser Gin Thr Ala 1105 1110 1115 1120

Ser Cys Asn Ala He Tyr Asn Asn Pro Asn Gin Asp Ser He Pro Ser

30 1125 1130 1135

Glu Ala Ser Ser His Pro Asn Gly Asn His Leu Lys Pro He His Arg

1140 1145 1150

Gly Ser Leu Thr Lys Ser Gly Thr His Leu Asp His Leu Thr Lys Asp

1155 1160 1165

Pro Asn Phe Leu Pro He Pro Thr He Ser Gly Gly Glu Gin Gly Asp

1170 1175 1180

Gin Thr Leu Gly Gly Lys Tyr Val Lys Leu Leu Glu Thr Lys Val Asn 1185 1190 1195 1200

Phe Gin Leu Pro Ser Asn Arg Arg Pro Ser Val Val Gin Gin Pro Pro

1205 1210 1215

Ser Leu Arg Glu Arg Val Arg Gly Ser Pro Arg Phe Pro His Arg He

1220 1225 1230

Leu Pro Pro Thr Cys Ser Leu Ser Ala Leu Ala Glu Ser Glu Asp Arg

1235 1240 1245

Pro Gly Asp Ser Thr Ser He Leu Gly Ser Cys Lys Ser He Pro Arg

1250 1255 1260

He Ser Leu Gin Gin Ala Thr Ser Gly Gly Thr Trp Lys Ser Met Glu 1265 1270 1275 1280

Thr Ala Gly Lys Ser Arg Leu Ser Leu Gly Asp Ser Gin Glu Glu Glu

1285 1290 1295

Gin Gin Ala Pro Ala Asn Gly Thr Glu 1300 1305

<210> 16 <211> 7913 <212> DNA <213> Drosophila

<400> 16 ttttctgccc gtttgtttgt gctcccgtcc aggtgaaggt taagtgctcc gagctgagga 60 tcaaggacaa gaaggaactc accaagcaat tggatgagct caagaatgag ttgctcagcc 120 tgcgcgtggc caaggtgacc ggcggagctc cctccaagct ctccaagatg tgagtatgcc 180 gcggcacaac gacaagcgtc acgaactaat tccggtgttt tgtgcattta tgtgcgttct 240 tatccataca gccgcgttgt ccgcaaggcc atcgctcgcg tctacattgt gatgcaccag 300 aagcagaagg agaatctgcg caaggtcttc aagaacaaga agtacaagcc cctggatctg 360 cgcaagaaga agacccgcgc tatccgcaag gccctgtctc cgcgcgacgc caaccgcaag 420 accctcaagg agatccgcaa gcgctccgtc ttcccccaga ggaagttcgc cgtcaaggcc 480 tagaatgcat ccagatactc cgactgtcta tagtgcgcgt taagggttct tcggtacaat 540 gaagaagaaa aactaaataa aatctttttt ttaaagtgaa aatagcgatg cgtgtttgat 600 tttgtgaccg aaaaaacgcg agtggcacat ggctttggcc atgggttcat ggaaattagt 660 taaaaaacaa aaaaacaagt gccgcattcc ctgttctaca tatgttagtc ggatccaatg 720 ggatctactt aactacttgt ggtccttaag atcattatag agcaaaaacg ttgagttagc 780 gccttgtaga agtaatggca aatcttaagt tcaatcttta attcagcctt ctttgaatat 840 gcaaacttga aaaacaccag aattctcaat tggtctacgt atatgtattt aattcgattg 900 tctttgatgt aagcacggcc atacatcgta aataattatg aactaacaag taataagtag 960 gtaattgata tgaattacaa gctctcgact gcgagctcga tcatactgaa tatgtttggc 1020 acatttggtt aatactattc ttctgcacag cgtgaaacag cggcgtgctg cggatgacgc 1080 ccgacagctc cttggagttc ttgctttggt gatagtttct actcggcatc ggcgacaacg 1140 gttcgcccca gaacttgagc agcgcaaaga tcttgtagta ggccactctg aaatagaaga 1200 tagattcgct attagcagct aaacccgata gcagccaaaa ctgccagcaa acttacctgt 1260 agttgcgatt gctggccgca tagatgatcg ggttaatgac actggaagcc caggccatca 1320 cggaggcgat gatgtgcagc caggggtacg aggtattgcg ctcgtcgtcc accacattgg 1380 ccagcattag cggcaggaag cagacgagga agcacagaaa gatggtgacc atcatgacgg 1440 tcagtcgatt gtcttcgcgc gccttgcgcg tgcatgtggt ggtcatgtag gatccgccgc 1500 cggacgacga ggagcccttg gccgctgcga tctggaagtt atcgtggttg cgaatcttct 1560 ttttctggtg cagcaccgta atgtagatgc acgagtacga aacgatgatc accaggcaag 1620 gcagcaggaa gccgatcacg aacagcgtct tcttgatcga tcgcccctcc ttcttgagta 1680 ttgtgcagga gaaggtggcc tcgtccaggc ccatctcgcc ccagatgccc aatatgggcg 1740

31 gcagctggga agataaaaac cgattagttg aatgtgtgca cacaaatcga agacgcctta 1800 cttaccaaca gcagaaagga gacggcccaa acgaacaaca gctgcagggt tatgaactta 1860 ggcttatata tctgcgagta gcggctgtgg caagcgatga gtatatatct gccaggggat 1920 tagggtgacg gttgcggatt agcttgcgac aatgcggact agacttgggc ctacctgttc 1980 agggtgatgc ccaccatgct gaggagtgaa acagccacat tgccatagaa gatcaccgga 2040 aagatcttgc acaatgtggt accaaaagtc cagctctgtc gttggaatcg agcaaattat 2100 aatcattcac taattgtata ttacattcac aggtataatg actcacctcc tggaagaatc 2160 gcactgcggt cagtggcagg ctgaaggagc agaagagcag gtcggagatg cttagcgaaa 2220 tgacgaaggc ggttgtggca tgctcccgta tcgtggggct cttgagcagc gccagcaggg 2280 taatcaggtt gcctgtgcgg caattcagca tagagaaaca ggttagctaa tcgaggagct 2340 gaatgtggga tgccaattac tcaccaagaa cgccgatcgt cacaaagaca caggcactaa 2400 tggccgcgaa taatgtcgcc gaatgcgggt agatcgattg cgtggcggcc gccggttcat 2460 ccatctgcat gtctgcgtcc tgaaagtagc ccgttgccat gcccatgtcc tgatccattc 2520 tgcgggggaa acaagcaaac gatgtgatta gccaatttca attacttatt tttgaacagg 2580 aaaaggagct gtatctttta aattggttgc attcaaatcg cttatgctaa tcctattgtt 2640 tttttttttt taatttgtta gcccgtatca tgagtaatta aaaaggaagt taatagccgg 2700 atgtagacaa ctcaatatgc atccgcttgg ttatttgaaa acaattaact tatgaagaga 2760 aatgaatgaa attaccattc ctaattgccc agaagcatga tgcttttgtt aagaagggat 2820 tgttaagaat ttaactatct aaacgaacta atgtgtacat ttctgtgctc cgcgataaag 2880 gaaatgtaat cagcaaaatc aagtttcagg cgcgtggaaa atctgtgaat gaatgaacgt 2940 acgagtaata caaaaagata actaatcacc gctttgcgga tgcaatagcc cagttttgtc 3000 gtcggtgaca ccgagtaaaa acccgatccg atcgacggga ttagcgagga agtctgcgta 3060 ctcccaccag cttatcgcat ccgagacatt tgatttatgt aaacggattt tgttataaga 3120 tttctgccga gccaagctgg ccaactggcg aatcgtaatg atcgagccgg tttgcacgcc 3180 atttgaattc acatttgtac gaattttttt tttatcaaaa gttcgagttt ttcaccaatt 3240 tcctcatcaa ccgagcaagg caaacggctt tgaataatat ggtgttatat atacatatat 3300 caaatcgctg ctgactgcgt gattgatggc cccaagatta catattatcg aatcaggatt 3360 cagaaggaga tcaatgtcaa atgcggacag gaacatgaga gacgcctgtt atgcgcaatt 3420 aaaaatttgg gtttaattgc tgtggaaact gttgttggtg gcatcttaag ttcctgttta 3480 acaacatcaa ctacttatgt acgtagaagc gtttaagcca tttgcataca gatgagaact 3540 ggcttttgtg ctaatcagcc aagatgactc cgatgatgat gactcattac ctgaccagtt 3600 ttcgctgctt tcttttcaac aactacttgt atatgtattg tatccaatag caatacattg 3660 gatttccatg gtctagtcac gtattatcat ttaattgacg ccaagtcgtg ttattgttga 3720 gctatcgagt tcagctcaaa catttcttat tcccatgaat aagccggcaa aaatatgcaa 3780 tctatgaaag ttaatataag caaaccttac tttgactcaa taccaatgca ctttgtgtcg 3840 ataggttcac gcaattgagg cgattattcc gataacccaa gcgattgact gttcccgttt 3900 cgattccaat tgaaatttgg aaatgtacaa tagttttgct atatgctgtc aagtacgctc 3960 ttatcttctc tgggttttct tcagagtttc gaaacgcttc ttcttttttt tgtttttttt 4020 tttttggaat ctcgtatttt ggaaggggct cccctctgga atttgttaca ctgtcgttat 4080 cattgcgaac aagcggcccg aagctatcag cgactttaac atttacaatg cactttttta 4140 cgaccaatta aatgtacatt ttcctttctt cgcccgttga taagcgaacg cgatgtggcg 4200 caggcaatgt gttgctcttg cgacacaaac gcaatcaaaa tggattcaat ttcgcttttt 4260 cccagtgaaa cgaagaacga accgaccatc atgatatgct gctctgcatg ttgcgtattg 4320 aatcaatgac aatttcaatt aagccgcccg ttcgtcatgc gttttcgtgg gcttcgaaat 4380 gctgataacg ctgctgtcct ccaactgctt tgcatgtgga cacaattcca tttatttaat 4440 tcttttattt ggatcggtta aattaaaaag cgccttgtta cgcatttaac gttgtttccg 4500 gtgcgtggtg gtttcatgct tctgggaacg gcaaatgggt ttaggattgg gaacccctca 4560 tcatccgtcc aaatatgggg agttcaagga atggaggggg gaggggggga gggggcggag 4620 cagcggtccg ctttcatgca tgatcaacat gtgtgtttgt tttccaactc tatgtgagtt 4680 gtttcagttc ttttcggtct cctcggttct actcagttcg ttcttacttt ctggcttttg 4740 tttccgaata gggggagcgc atcgggccgc aactggaaat ggaaatctga atatgcatcc 4800 cggagcatcc cgtccgaaat gagcaccatg cgccatgccg tttcgtttaa ttccctaccc 4860 ataaatgcgt gtccaaacag cagagggcat ttcaagaggt ccaactatta gctatgtgca 4920 tatataattc tctagatata ttaattcagc taaagtgcta accgcgagtg tgccgccagt 4980 tgcccctcaa cagtttgcaa cgatgatgat ggcacagata tcagagataa cactcagatc 5040 gcgcccctca caagtatgct cattatgtac attcatatgt acatatgtac acacagctaa 5100 gcacataagg aatacgatat gcgctatgta catatataca tatttacatc aaagtcttat 5160 cagcctcggg ttcccaccgt ccaaaaaaaa aggcggaacg aagctttata aataatcaat 5220 caacaaatat ttacaatcaa gtatttatgt agcgggcgga aagtcgaatg caaataaggt 5280 tagacgcatt tgtacatatg tattttctta aagggttcct ctgatcaata tctgcccgtt 5340

32 tttatctagc cccgtttata aggctgtgaa tgccccgatt gtgttggtcg tgatatcaat 5400 taaatcggca taatctcatg tcatcttttt aaacattatg atagataaaa tgtattataa 5460 cgactctaat tacattggga ttaaatgggt tttcggaaaa tacctatgca gtaaatcaaa 5520 tttaagatca atgtgcagtt atttggggtt tcttgagtta ggacctctgt tttaatattg 5580 agaattactc gatattatct tccgttttat tttattttct gatcgtgtcg gtgcacgaga 5640 aatacatatt tcccactttt gttgcatttc gctgactaat cgaaagctaa ataccaaata 5700 agtttccgat atggggggta tgtatgtaca tacatacata tatagtacga gtatatataa 5760 tatacactga ataagcccga gcatacatat gtacatatgt agatagtgca catgtgtatt 5820 gtggatcgtt ttggagctgg gtttttcttt gcttttcgtc gtttttaaga gacttgagct 5880 gaatgagtcg ctaccaactg ttgcggtggg ttaaagggtg gggggagggg gcgaatgggg 5940 atgggggatg aagatgatga ttcatgcagc tgatgtttgg acagggaaga aagaaagagc 6000 gaaagagaaa gcaaatcgga agcggcggta tcaaacaatc tgtttaaata acaacaaaag 6060 actttataag cctgactttc atttccattt ccaatttatt tttcccaagt ctggctcatt 6120 ttgtgcaaat aaacaaatga ctcatttgtt taaaaattcg atgagactca aggaatgtca 6180 cattcacaaa aattttcaat ttgaaatctg aaaagattca acagcataag caaatgaatt 6240 taagattgcg atatttgggt attatcctta attggctggc tgcctaatgt agatttgttt 6300 ttctcggtgt accgatgcat cctctttgcc catccacttc tttctcccct ctttgctgat 6360 tttttttttt tttgttttgt gagagggtgg aattcgggat ttgggatgtg agcgagaagg 6420 atggccatat tttgaattgt ggaaacagcc gttccattat cgttccatta caaatgcaca 6480 cacacacaca cacacacgcg cgcgtgcagt ttgcgcttct ctgtgtgtgc gtttggacca 6540 aatgcaataa caataaaaac gcgcaactca aattgttaac aaaggtaagg ccgttttttt 6600 ggccggattt ggattctggt cttgaaagag aaacacacac acacacacac gcacgcaaaa 6660 aaccaacgaa aataataaca aaacaacaac tcacccgaac tcgaacccgt ttcactgttt 6720 tccgcttatt ataaatttat acttcgtttg gcgtttctta aatgctttcg aattgcattt 6780 tggatttgac attaaatcgc tccgcgcagc acagtaacaa aaataaacgg aacaaaataa 6840 atacaaccag ccgattctgg ccttctcaca attccgactt ttgaattatc gaaacagaag 6900 cgctgcttgg gccaactaag ccaacttaac taaccgatcg cagagcgcaa agtgtcgtat 6960 tttcactgtc gtcaattaac aacagcggca acaagaacaa caaacgaaat gagcggctgg 7020 gctacagttt tttagtccga gcgcgatcga acatgttggc tgcctggcaa caagttcgat 7080 gcgaactttt ctattgatct aagaaatcgg cgttctatcg attgacgcgc tgcgcaggcg 7140 cctatcgatt tttgaaattc taagcccgcc ttaaaggata tttgtagaaa agtagcttgc 7200 aaagaaatta aattccttga aataaaaaag aaatttagta ctctcgttct atactcactt 7260 ctattcactt gcggttagtt agttagtttt taatgccaca tttttatgat gatgactttt 7320 tttcagctca tctatgcgca atcaattttg cgccaagcga cagctgcaca tagtttcttt 7380 tgaccaagca atcatttatc atataatttt ccaagtagta gtgccaagtt cataactgat 7440 ggagtgtgct gccaatttgc atgttgtgga gccattcagt ttcaaggtcg cgctaattaa 7500 atactcgtta caagtgatgc caaatgtata aatatttgaa cagaacgtat taaattaata 7560 ttatccacta agagcactat tttaaattct taaaaaccag atgcacgtca aatagatgta 7620 cataaaaagt atatttactt acaaatatca tacacggacc tgttttattc ctcatcactg 7680 gccattagtt gataacatgt ggacttctat gatatcctgc tgcatttttg ccgtttagtc 7740 aggatttaga gcttgtacac aatgcgacag ctgaaagggc gaaatcggtg caatcgtgct 7800 gttcggcatc tgaaagttca gggcaagatg tggttgaaaa atcttaaaag cggtttggaa 7860 caaattcgag gtgaatctat ccaaatcgtt agaatcccat gagtacgttc atc 7913

<210> 17 <211> 1399 <212> DNA <213> Drosophila

<400> 17 ggcccaagca gcgcttctgt ttcgataatt caaaagtcgg aattgtgaga aggccagaat 60 cggctggttg tatttatttt gttccgttta tttttgttac tgtgctgcgc ggagcgattt 120 aatgtcaaat ccaaaatgca attcgaaagc atttaagaaa cgccaaacga agtataaatt 180 tataataagc ggaaaacagt gaaacgggtt cgagttcgga atggatcagg acatgggcat 240 ggcaacgggc tactttcagg acgcagacat gcagatggat gaaccggcgg ccgccacgca 300 atcgatctac ccgcattcgg cgacattatt cgcggccatt agtgcctgtg tctttgtgac 360 gatcggcgtt cttggcaacc tgattaccct gctggcgctg ctcaagagcc ccacgatacg 420 ggagcatgcc acaaccgcct tcgtcatttc gctaagcatc tccgacctgc tcttctgctc 480

33 cttcagcctg ccactgaccg cagtgcgatt cttccaggag agctggactt ttggtaccac 540 attgtgcaag atctttccgg tgatcttcta tggcaatgtg gctgtttcac tcctcagcat 600 ggtgggcatc accctgaaca gatatatact catcgcttgc cacagccgct actcgcagat 660 atataagcct aagttcataa ccctgcagct gttgttcgtt tgggccgtct cctttctgct 720 gttgctgccg cccatattgg gcatctgggg cgagatgggc ctggacgagg ccaccttctc 780 ctgcacaata ctcaagaagg aggggcgatc gatcaagaag acgctgttcg tgatcggctt 840 cctgctgcct tgcctggtga tcatcgtttc gtactcgtgc atctacatta cggtgctgca 900 ccagaaaaag aagattcgca accacgataa cttccagatc gcagcggcca agggctcctc 960 gtcgtccggc ggcggatcct acatgaccac cacatgcacg cgcaaggcgc gcgaagacaa 1020 tcgactgacc gtcatgatgg tcaccatctt tctgtgcttc ctcgtctgct tcctgccgct 1080 aatgctggcc aatgtggtgg acgacgagcg caatacctcg tacccctggc tgcacatcat 1140 cgcctccgtg atggcctggg cttccagtgt cattaacccg atcatctatg cggccagcaa 1200 tcgcaactac agagtggcct actacaagat ctttgcgctg ctcaagttct ggggcgaacc 1260 gttgtcgccg atgccgagta gaaactatca ccaaagcaag aactccaagg agctgtcggg 1320 cgtcatccgc agcacgccgc tgtttcacgc tgtgcagaag aatagtatta accaaatgtg 1380 ccaaacatat tcagtatga 1399

<210> 18 <211> 386 <212> PRT <213> Drosophila

<400> 18

Met Ala Thr Gly Tyr Phe Gin Asp Ala Asp Met Gin Met Asp Glu Pro

1 5 10 15

Ala Ala Ala Thr Gin Ser He Tyr Pro His Ser Ala Thr Leu Phe Ala 20 25 30

Ala He Ser Ala Cys Val Phe Val Thr He Gly Val Leu Gly Asn Leu 35 40 45

He Thr Leu Leu Ala Leu Leu Lys Ser Pro Thr He Arg Glu His Ala 50 55 60

Thr Thr Ala Phe Val He Ser Leu Ser He Ser Asp Leu Leu Phe Cys

65 70 75 80

Ser Phe Ser Leu Pro Leu Thr Ala Val Arg Phe Phe Gin Glu Ser Trp 85 90 95

Thr Phe Gly Thr Thr Leu Cys Lys He Phe Pro Val He Phe Tyr Gly 100 105 110

Asn Val Ala Val Ser Leu Leu Ser Met Val Gly He Thr Leu Asn Arg 115 120 125

Tyr He Leu He Ala Cys His Ser Arg Tyr Ser Gin He Tyr Lys Pro 130 135 140

Lys Phe He Thr Leu Gin Leu Leu Phe Val Trp Ala Val Ser Phe Leu

145 150 155 160

Leu Leu Leu Pro Pro He Leu Gly He Trp Gly Glu Met Gly Leu Asp 165 170 175

Glu Ala Thr Phe Ser Cys Thr He Leu Lys Lys Glu Gly Arg Ser He 180 185 190

Lys Lys Thr Leu Phe Val He Gly Phe Leu Leu Pro Cys Leu Val He 195 200 205

He Val Ser Tyr Ser Cys He Tyr He Thr Val Leu His Gin Lys Lys 210 215 220

Lys He Arg Asn His Asp Asn Phe Gin He Ala Ala Ala Lys Gly Ser

225 230 235 240

Ser Ser Ser Gly Gly Gly Ser Tyr Met Thr Thr Thr Cys Thr Arg Lys 245 250 255

Ala Arg Glu Asp Asn Arg Leu Thr Val Met Met Val Thr He Phe Leu 260 265 270

Cys Phe Leu Val Cys Phe Leu Pro Leu Met Leu Ala Asn Val Val Asp 275 280 285

Asp Glu Arg Asn Thr Ser Tyr Pro Trp Leu His He He Ala Ser Val

34 290 295 300

Met Ala Trp Ala Ser Ser Val He Asn Pro He He Tyr Ala Ala Ser 305 310 315 320

Asn Arg Asn Tyr Arg Val Ala Tyr Tyr Lys He Phe Ala Leu Leu Lys

325 330 335

Phe Trp Gly Glu Pro Leu Ser Pro Met Pro Ser Arg Asn Tyr His Gin

340 345 350

Ser Lys Asn Ser Lys Glu Leu Ser Gly Val He Arg Ser Thr Pro Leu

355 360 365

Phe His Ala Val Gin Lys Asn Ser He Asn Gin Met Cys Gin Thr Tyr

370 375 380

Ser Val 385

<210> 19 <211> 3574 <212> DNA <213> Drosophila

<400> 19 gttcgtttga tcggttgacc tcgatttatt tactgctatg caaagctaaa attcaaaaat 60 ccctactcat agatgaagtt ttttgcacac tttaggtgta acttggtgct ttaacttggc 120 gtttctagtc ttaaataatt ggcaagatta tctgcctaac ttttggtgac cccaactttt 180 aatcacacac caagcggaat tatactaagg tttatttccc ttggcatcag actgtcttct 240 tcttcgctct tccagctctt gtctttatta aacctggcca aggacctgta acttcgttta 300 attaagtaat tcaatgaaat tgacagctgt ttgcttgggt caagcataat tgatgactac 360 tcataatcaa aacagaagtg ctgccaatga atgggaagcg gaagtctggc ataaattaca 420 ggtctgtcca tccgaagcgc aatcatcata taattgtcat ggaaccacac ttggcactca 480 cttttgcctg gcttctgctc ctgcgaacgc tgatgttgct ttgtgctttg tgctttctgc 540 ttgatgcttt ttgctttgtg cccaagtctc gtgactccac tccactcgga gtggcatcca 600 tggttaggag aacagcaata atgaggcaca ccaaccggcc aattggcaat tgtgcgaggt 660 caaacacaac cggtggagga aactggtgtc ggccgcacag ggaagactta aattttcttt 720 aattgctcga atttatgggt tggtagtggc ataacgacaa ttgtccaagt caaggtcaca 780 aatgatgctc ctgccttttt agttcgatac acacaaagaa aaggggacca tacatataca 840 agcaaccaac tagatgaaac ctattttaag gacggttgaa ttgttggctt ttaacatagt 900 agattaactt caaaattagc agttactact actaataacg agctaagcca ctcatttgcg 960 taaacacttt ctatctgtgc acttttatct gcttgaatag tgtctgggtg atggcctcga 1020 ttgccgtggt tggcaaccta ttggtcctgc tcggtcgcta cttctacaaa tcacggagca 1080 acgtggagca ctcgctctac cttcgccatt tggccgccag tgatttcctc atgggcattt 1140 acctcacatt gattgcctgt gcggatatca gttttcgcgg cgagtatatc aaatacgagg 1200 agacctggcg gcatagcggc gtttgtgcct tcgcaggtgc gtatccttcg acatcctagc 1260 catttccatt tcgtaatgga atgctaatgt gtattacgta ttcgccgtgt aggcttcctc 1320 agcaccttca gctgccagtc gtcgacgctg ctgctcacat tggtcacctg ggatcgtctg 1380 atgtcggtga cgaggcccct caagccacgg gatacggaaa aagttcggta agtgtgaact 1440 acaatagata tgtaataaag tgctgggcaa agttattgtt tattctatta cattaattac 1500 ttttgctgcg gacatttgct gatttgttga ctgctcaaat atcaatgcac agaatttgtt 1560 taccctactt gaattttgtt cgtaaatgca attatgtttg ttttgaccgc cgccttacta 1620 tgtacaatat atattttctg ttgcttcatt ttagtttgca aaagctatgg ttttgtatgt 1680 gtaagctatg ataaattatt gaaatgacaa cttccacagc attgtcctac gccttctgct 1740 gttgtggggc ataagtttcg gattagctgc agctccactt cttcccaatc cgtactttgg 1800 tagccatttc tacggcaaca atggtgtctg cttatcgctg catatccacg atccctatgc 1860 gaaggtaata caccatttcc ttggaaacgc ctgttctaat attccaaaat gtatattttt 1920 agggttggga gtactcggcg ctgctgttca tcctggtcaa tacgttgtca ctgatcttca 1980 tcctcttttc ctacattcga atgttgcaag cgataaggga ttcgggtggc ggaatgcgaa 2040 gcactcacag cggtcgcgag aatgtggtag caactcggta agtttggata attcaagtaa 2100 aatgatttaa ttattgaaat atcatgtttt tacagctttg ccatcattgt gaccaccgat 2160 tgcgcctgct ggctgcccat aattgtggtc aaattggctg ctctttcagg caagttcatc 2220 ggcaacgcct ttaaatgatt tattttgatt atcaacttat tcgtatatat ataacccctt 2280 tcaggctgcg aaatctcgcc cgatctttac gcctggctgg cggttcttgt gctgccagtg 2340

35 aactcggccc tcaatccagt gctctacaca ttgaccactg cggcctttaa gcaacagctg 2400 cgtcgctact gtcacaccct gcccagctgc tcgctggtga acaacgagac ccgatcccag 2460 acccagactg cctacgagtc cggactgagt gtcagtctgg cgcacttggg cggtggtgtg 2520 ggcggcgggt cggggcgaaa gcggatgtca caccggcaga tgagctatct gtaggcgggc 2580 gcaactggct taaaatgcag cacgagatca acagactggg gctagtgggt gggtggcatt 2640 acaacaggac acttccatgt aattggtccc ttagactatt ggtattatac gtacttattg 2700 atacttattc taatatcaat tttaaattac ttataacatt tgaggatatg ataacataaa 2760 ccttagacaa gagattccag ctatttaagt ttcttttttg tatattattt attttaccaa 2820 tcgttttaag gcaaacctct tacaactgtc caaagaatat cctaactatt tgttgcatcc 2880 ccatttattc gacctgccca atgggatatt gttacatgtg atctaatagt taaatcaaat 2940 tttaatttta taaatacata ttcagatgtt aattgaagct tttgaacata ggacttgcaa 3000 tcgaaggccg caaatgcctg ccatccggct ttctatgcgt tgccctgagg ttcagtggct 3060 acatcgagat ccgcctggac gtgatagggt ccctcgttca cataggccgt gaaacggatg 3120 gtttcggtgg gcgaaaactc agcgctagcg gacagaatct ccataatttg ccacttcata 3180 tacttaatgt ccctgtgcag atccttttga cgcgaaagaa ggaactccac agcaccgccg 3240 gtattcttta gagctacaat gccccagttg tacttacaaa tggttttcaa gaacgacaag 3300 gcggccattt gaagatcggg gaacggagtg tttatcaggt ccataatgat attagcatgc 3360 gctcccccag cgaagcactc gtaccagttt ttaccaatgt tactgaaaaa gaagagaatc 3420 attagaagaa aaacttcaat tatagagtta agcattacat gatttctgtg gcaggcggcg 3480 tcttgaagtc ataaatcaca tccagggagt tgagcagcct cttcttgatg tgcgccgata 3540 gcttcttagt atgcgagcca tacttcttaa agga 3574

<210> 20 <211> 1015 <212> DNA <213> Drosophila

<400> 20 tgtctgggtg atggcctcga ttgccgtggt tggcaaccta ttggtcctgc tcggtcgcta 60 cttctacaaa tcacggagca acgtggagca ctcgctctac cttcgccatt tggccgccag 120 tgatttcctc atgggcattt acctcacatt gattgcctgt gcggatatca gttttcgcgg 180 cgagtatatc aaatacgagg agacctggcg gcatagcggc gtttgtgcct tcgcaggctt 240 cctcagcacc ttcagctgcc agtcgtcgac gctgctgctc acattggtca cctgggatcg 300 tctgatgtcg gtgacgaggc ccctcaagcc acgggatacg gaaaaagttc gcattgtcct 360 acgccttctg ctgttgtggg gcataagttt cggattagct gcagctccac ttcttcccaa 420 tccgtacttt ggtagccatt tctacggcaa caatggtgtc tgcttatcgc tgcatatcca 480 cgatccctat gcgaagggtt gggagtactc ggcgctgctg ttcatcctgg tcaatacgtt 540 gtcactgatc ttcatcctct tttcctacat tcgaatgttg caagcgataa gggattcggg 600 tggcggaatg cgaagcactc acagcggtcg cgagaatgtg gtagcaactc gctttgccat 660 cattgtgacc accgattgcg cctgctggct gcccataatt gtggtcaaat tggctgctct 720 ttcaggctgc gaaatctcgc ccgatcttta cgcctggctg gcggttcttg tgctgccagt 780 gaactcggcc ctcaatccag tgctctacac attgaccact gcggccttta agcaacagct 840 gcgtcgctac tgtcacaccc tgcccagctg ctcgctggtg aacaacgaga cccgatccca 900 gacccagact gcctacgagt ccggactgag tgtcagtctg gcgcacttgg gcggtggtgt 960 gggcggcggg tcggggcgaa agcggatgtc acaccggcag atgagctatc tgtag 1015

<210> 21 <211> 334 <212> PRT <213> Drosophila

<400> 21

Met Ala Ser He Ala Val Val Gly Asn Leu Leu Val Leu Leu Gly Arg

1 5 10 15

Tyr Phe Tyr Lys Ser Arg Ser Asn Val Glu His Ser Leu Tyr Leu Arg

20 25 30

His Leu Ala Ala Ser Asp Phe Leu Met Gly He Tyr Leu Thr Leu He

35 ^• 40 45

Ala Cys Ala Asp He Ser Phe Arg Gly Glu Tyr He Lys Tyr Glu Glu 50 55 60

36 Thr Trp Arg His Ser Gly Val Cys Ala Phe Ala Gly Phe Leu Ser Thr 65 70 75 80

Phe Ser Cys Gin Ser Ser Thr Leu Leu Leu Thr Leu Val Thr Trp Asp

85 90 95

Arg Leu Met Ser Val Thr Arg Pro Leu Lys Pro Arg Asp Thr Glu Lys

100 105 110

Val Arg He Val Leu Arg Leu Leu Leu Leu Trp Gly He Ser Phe Gly

115 120 125

Leu Ala Ala Ala Pro Leu Leu Pro Asn Pro Tyr Phe Gly Ser His Phe

130 135 140

Tyr Gly Asn Asn Gly Val Cys Leu Ser Leu His He His Asp Pro Tyr 145 150 155 160

Ala Lys Gly Trp Glu Tyr Ser Ala Leu Leu Phe He Leu Val Asn Thr

165 170 175

Leu Ser Leu He Phe He Leu Phe Ser Tyr He Arg Met Leu Gin Ala

180 185 190

He Arg Asp Ser Gly Gly Gly Met Arg Ser Thr His Ser Gly Arg Glu

195 200 205

Asn Val Val Ala Thr Arg Phe Ala He He Val Thr Thr Asp Cys Ala

210 215 220

Cys Trp Leu Pro He He Val Val Lys Leu Ala Ala Leu Ser Gly Cys 225 230 235 240

Glu He Ser Pro Asp Leu Tyr Ala Trp Leu Ala Val Leu Val Leu Pro

245 250 255

Val Asn Ser Ala Leu Asn Pro Val Leu Tyr Thr Leu Thr Thr Ala Ala

260 265 270

Phe Lys Gin Gin Leu Arg Arg Tyr Cys His Thr Leu Pro Ser Cys Ser

275 280 285

Leu Val Asn Asn Glu Thr Arg Ser Gin Thr Gin Thr Ala Tyr Glu Ser

290 295 300

Gly Leu Ser Val Ser Leu Ala His Leu Gly Gly Gly Val Gly Gly Gly 305 310 315 320

Ser Gly Arg Lys Arg Met Ser His Arg Gin Met Ser Tyr Leu 325 330

<210> 22 <211> 8412 <212> DNA <213> Drosophila

<400> 22 ttttccgcca aattcgctgg cttttaagtg ctcacataaa tgaaattttc aaatagcaaa 60 taacatagga ataatccttc taaatcgcaa tataaaaaca tatatacaag gagtggtaaa 120 tgacagtatt ctattaatgg caaaacgatt tatttaaaca gacgtcgcat ccgcataaac 180 gatctttcac actttttatt aacggttagt ataaataaaa aaaaacatta atccttagtt 240 tatttaacca attttgtttg ctgaaatcga ttcttgaaag agaagctgac atttttttta 300 tatatgcctc cctacttcag gcagtgcgaa cataccgcat caacgcgact tgtagcggcc 360 gtgtgaaaag gctattttgt ggttagcgca gatctgcgct gcagtgtgac cccggctaca 420 ggtatttcgg catcgcacag ggtcacactc gcccaggcac ccgtataaaa tccccgcccc 480 cctgatcgac gatagtattt cgaaaaaaac gcgaggaaaa gtctgatgcg cgttaaaatc 540 ggagcgcaaa tcgtgcatat attttttttt acacaccgcg cgccgtgttt acgactgaaa 600 acggagactg actgaaaagc cttggcgcac aagcacgcaa tgaaaacgca acgataagaa 660 tgtgatattg tgataaatac atgattcgct gacaactcta ttttatattg gaatgcattc 720 gaaatcgaac gcagcgcagc gtgtgttgtt tacttaacga ttttcggtgt ttgtttgccc 780 aacttgcggc ggtgaaattc agcattttct gattttccat ttgccaacga aagagaggaa 840 aagtgaaaag tgctattcga cgaagcgaaa cggaacgcaa aatcaaaaga aaaacagcat 900 agctaaagct atgtgtagta catagccaca taaattgcaa attgaggcca agagacaaga 960 gaacctgaaa tccacacaga tcttgacgag tgagctaacg atggacagga gtcggagtag 1020 cagagctgcc agcagcaacc agttcatcag gccatgtggc ctactgacga ccgtcatcct 1080 gctgcagacg cttgtgtcga tgagtttggc catcgaggag atgtcgccac caccggccgc 1140 cccgccacgt ccatcgccgc cgcccaccgt gaagctcaac aagtgctgcc attcgggcga 1200 gtatctgaac gatggcacct gcatcgccgg cagcgaagcc ctgtggctgc ccatggtgta 1260 cttggtgcag cagcagcgct tcttcgagcc ccatggcgcc agtccgcgat tcttgaagtt 1320 cctgcccaat acgagaccca cgtgccgaaa ggaccagacg acggagatct ttcgcagccg 1380 cggagccaat gtgatgctct ttcccaatgg cacgctctat gtgcgggaac gcgctctaat 1440 ggtccagccg tcggattact gtgtcgactg ggaggtggcc gtcgtttgct tgaacgacag 1500 tcagccgatc aatgctctgg aggatcccga ttatgcagcc aatcctctcg tgcagcagga 1560 gccgcccaag gctagcctgc gactgagcaa gtgctgcggc aagtggggca gctataacac 1620 gcagctccag aactgcgatc tgcagcccaa ccatcaggca gccgtcgatg gactgctgcg 1680 attgtcgccg cagctaccgg agggcagcta tcagactagc tacggcctgc ccgactgtgg 1740 ccaacccggt ggctactcca ttgccggtga ttggcaggat gccaagctgg atcggaacac 1800 ggccatgctc cagttgccgc acaagaacct cagcgccgga caatactgcc tggagcacac 1860 gcagcgcgag ggcgaggtga agatcatagc ctgccagcat ttgtttagct ccgcggcagg 1920 agccggcatc cacgacggct ccattggagg caccatcgag caggccaatg gccagaatct 1980 gcagaaggcc gtcctgactg gtggcatact tgtgtccatt gtcttcctgt ccgccacttt 2040 ggtggccggc ttcctgctgc ccgctgtgca tcatgcgctt cattggcgct gccaaatctg 2100 ctatgtcacc tgcttgctat tcggcaaaat actgctggcc atcgaggagc tgagctccag 2160 cctgcagccg ggcagtgccg cctgccatac gcttgctatc accatgcagt tcttctttct 2220 ggccgccttc ttttggctga acaccatgtg cttcaacatc tggtggacgt tccgggactt 2280 tcggcccagt tcgttggaac gcaatcagga ggcactgcgt cgctatctgt actccctgta 2340 cgcttggggc ggtcctctgc ttatcacctt cgtggccgcc tgcgtggacc agctgccgga 2400 gacgacgcta ctgcgtccgg gattcggaca gctctactgc tggttcgaca atcgcaatct 2460 ctcgatcttc gcctacttct acggacccat tggcctgctg ctgtgcgcca atatagcgct 2520 cttcgtgtcc accacccatc agttgacgtg cggcctgtgg aaacgggacg atgtcaagtc 2580 ctcatcggag aagtccgccc tgggacgcgt ctgcctgaag ctagtcgtcg ttatgggtgt 2640 cacctggata gcggacattc tgtcctggct agtgggtgga ccgcatggcg tatggttctt 2700 caccgacctg atcaacgccc tgcaaggcgt cttcatcttc atcgtggtgg gctgccagcc 2760 gcaggtgtgg accgcctgcc gcaggatctt ctgtccgcga ttgcgtcatg acatcaccaa 2820 tacgaccaac ggtgtccagc attcgagcag ctcgcagggt ttgccctcga tggccggcgg 2880 cacggagatt acacagaaca ccaccaccac caccacgaca accaacacga ccgccactca 2940 catgcccagc aatccggcgg aggatgaggt accggagaag gctcccattg cccccgtcgc 3000 acccatcgtc aaaatggaga ccatttgcta aacgtaagtt gaacacccga tagccaatga 3060 agtgtgcttg taaagagata gctctgtttg ccagcgcgca aacaaagcgc ctgctgttcc 3120 cactcccagc gcagtttgcc aagtggctta caaaacgcgg ctttaagcac acacacacac 3180 acacacacac ttgctgatag acttatcggc cttaatgggc tttagggccc agccgggaat 3240 gcaaagtatc tcaatgagct ggctggctgg ctggctggct gtttgctcgc cggttacgcc 3300 atgcatcgca gcagtttcga tcctataaag cgcacgtatg tacaggtggg gccacttcaa 3360 tatcactaag cagctttagc ttcaatagac ttcaatcggt ggaaggtttg gtatttggac 3420 ccaagaacct aagtttctta ttaagtttta gtctttcaaa aatagcgtgc taaatagagg 3480 gtcttaaatt aactcgaaaa tgatttagaa tccgtgtaaa ttgaattgac acattagctg 3540 aattttccgg tatataacca aaaatgtccg gacgatatat gtgtcgtaga agatagtgtg 3600 ataattgcgc tgtctgtgga tttaacccaa ataccaatga ggtattcaca aaatgtgaaa 3660 acaaatagga aaccccgaat ttgtcatgcg ccgacaactt tcgagaacca accaccacca 3720 tatgaagata aaaaacaaaa gaaactagtt tggttttcta tgggggaaaa cgatacgaac 3780 ttttcaattc aaaacctttg gagtttcaac ggtcaatggc catgttggaa aatacccttc 3840 tctataggac actattcatc tcacaccccc catgtggact atacgctatc cagatgaaat 3900 ttaagggttc gagatttcct gacaacttgc ggctacctgg agcgtttttc caaccaggcg 3960 ccggttgaaa aagtctagca cgttttcgtt tcgttttatg gttttatagg gggaaattta 4020 cgtatttacg taggataaga agatcgtcct gcgatggtca aatagtgacc atattcttca 4080 tttgcatgac cgaaattgtt taacaacatg cgccaagttt acgatttcgc gtgcaccact 4140 tgagttcgag tatggtcata aagatgaaaa tgttgccgct gtgtgccgtt atgtttttca 4200 tcggaaaact ctgacgccgg gccgggcgaa ttcgattttt gaatttcctg tcgatttcca 4260 catttccaca tggccataaa gtaatcagcg caacccttga cacacacgca agcgaagata 4320 atggaaatcg ttgctggcat ccgtatcggt tggattcaaa aaatgtgtgt tgccgaatcc 4380 gtaagggaaa atcgagttta aattggactc accggcgacg atggcgatgg tgatggtgat 4440 aagcacacaa cacaccatcg tcttgtttgg atttcggccc atttacttat ttacttgtta 4500 ctttgttagt ttgttagttt gttagtttgg tcgcctcgag tggttttgac acatctccca 4560 atgatccaa tggcaaacat gcggacaggt ctcgaactcg gcacaatcta caattatcta 4620 aagaaacc tctgtgcggc gatcataaag ttttgaaaaa caataattcc attttcgggc 4680

38 actaaaaaaa aaacagggca acttgaaatc tagcattaaa ctggtggctt aatgttccaa 4740 tgaaaagata aggatttaac aataaaaaaa aacttttttt ttgtatgcac tgcatgttga 4800 tagcaacatt aatgaaagaa actaatcaat gaagtttctg tttctctata ttaacaacaa 4860 atgctgcttt gtttaggcca tgtttttgtt attagagccc aagaaacatt ggtttgcatt 4920 gcacaaaggc gtatggaaaa tgtgtaatta cttcagtttg taacattttc gaatatgaca 4980 gctgctggtg gcagttaatt ctttgccctc gcgttttatt gtttgttact ttttactttt 5040 attttttatt tttttttttg ggccctgatc gcgtcatact ttttgggatg cgtgtctgtc 5100 cgggtgaaca gatgtgctgt ctgtctgcca ttcgcttgtg tgtaggtccg tgttggaatc 5160 agaggttttg cccaaacgaa agagaaaaca aaacaaacag tgggtttttg gcccatgggc 5220 ccattcgatg agattgcgca accgagttaa atggcctggc ccctgaaaag ctgaaaaccg 5280 aaaacagaaa catgaaatct gaaatctgaa attgtggaaa tctgaaattg tggctggcac 5340 acgcaacact cgtaatcaga ctaaaaaaaa aaggggcagt cagtcggctt aaaactgtga 5400 cctgcatgca tttgccaact gcagactgca aactgcaaac tgcaacttcg aaggcaaccc 5460 gaaatgcatc tgcaactgca actgcagctg ccgtgccatt tgtgttcatc tacataatcc 5520 cagagcagcg tgtccacgtc acgctcatca caacgcgacg gtgcaaaaat gcagcgaaat 5580 tggatgcgtt gctcgtttgt caactgaaat ggtccagatg cacaatgcaa gggagggaag 5640 atgcggcaga aatgcgccgg aatcgatgca gtaatgcgtt tcaagctatc attatgggat 5700 cacatggggt cacatcagtg cgaaaatgct aatgctatat gggctaaaac cagttgggaa 5760 ttagagcgcc gtacaagctg taagctaagc tgatatgcaa taccgcttat taaagagcat 5820 ttaaactatt tgacttgaaa atatgactaa caaattgagc agggaaaatg cttttccttc 5880 ggaaaaaatg attgtgtgcc aaaaactaaa aacgaaagtt tccctactat tacttttggc 5940 atcgcccaaa aaacactttc tttcattagc catttcactg attatctttt ttggtaacca 6000 agcggagtaa tcatcataag cacacagcgt taaactattc agctatttcc agcttgttga 6060 gataactaaa agctcggaca cgcttgagtt ccactttttt tttttttttt ttatctccat 6120 caacatttaa taattaagtg atttcgctta ttgttctagt atttattagc gcattaccta 6180 attgtttgac acgacgaaac atgaaatgat tactaatttc atcatagaat gccagtgacc 6240 catgctcgtt ggcatttcga ttataataat attcgcagtt gcataaatat agattgtttc 6300 cgaacgtgac ctgtacttcc tagtgcaact gaatcttttg cgtttctggg tcagctttta 6360 tctgcctagt tcgctgacat ttcaaaagtt tgcaacactt ggcagcttgg cagcgtaatg 6420 aattccttcc tgttgactcc gccacgcaaa ttggcacaaa tttcgcaata agaatactta 6480 atgtccaact ccagacgcaa tcgcagcggc acacgcacac atgctctgcg ttaatttgag 6540 tttagcggca atttttaatt tgaacgttct gcagtttttc aacttataat tgcactctgg 6600 cccatttaca ttttacgcag ggcattatta ttatttcttt tttttttttt aatttttgcc 6660 tgctgagtcg gtcgacatcg gattcctcgt tggaggccga aggaagcgaa gtagggggca 6720 ttgttgtcat gcatccacag ttgcggttaa tgcaatagct ctgagatgga taataattac 6780 ctcggtcctt gaatggtgcg aaaatatctt ggcagttcct ataaaagcat agcattgcgt 6840 ttggtacatg aatttcattg gcaaataata agtatttcat ctggcagcag ttcacacctc 6900 aaatcatatc gcgcaaatgc caccttttcg caagaatttg aaatcaaaat aaatctcaga 6960 attcctgatt acgcgatgcc tggaaatcta aacagatcat gagtaagccg caaatgtttc 7020 agctaagaaa aatgaaaaga acaaagtttc cgctaagggt agttggaaaa gtagtcaaat 7080 tggtttactg atcaatatta cttttagatc tctctgttgt tttatttatt tagcagtgta 7140 aactaagact gcaagtccat gaactatagc cattttcaac actgcttcta agtactaatg 7200 tcttgagtgc actgtaccca catgcgcacg catatcatat gaaaatttgt acttatttgt 7260 gccccttttc tttcttattt ttttttttgc agacaactga gacgacgagc gacaatgcga 7320 aagtcaggcc cggatacaaa agtccagacc tcgagcgagc gaaataatgg caatgggcag 7380 ctcagaaata agaaagaaag aatggaaaaa acacgaaaaa aaaacgctgc caaagctgga 7440 gtttcgagac gagcgcggca cacacttgcg caatcgcagc aacaaaacca agctgaccag 7500 ctaattgtgc gagtgtacga gcgaatgagt gtgtgtgtgg ttgtgtgtgt gtgcaagcga 7560 cttgcgcgtg attttgaaat cggccaacaa ccgctgggga acaaaacgta ctcagtatgc 7620 cagtattcaa cttcaattta agccagcgca caaaagaaac gtattatttt attcatcatc 7680 atcatcataa tcgcatagca tcgcatcgca tcgcatcgca tcgtatcgca gaataacggt 7740 aaagcagttc gggtcacatt aacacgttct aattggacac tccggtcagt gttgcgaaat 7800 ggaatgtgca gcataacgaa acaggaattc agcctagaca aaacaaagca gcgctattgt 7860 ggctctttct ttcttttaag cacttttagc caacagaaat aaaaacacga gggctttatg 7920 tgtgtgcatc tggctgtatg tatgtgtgtg gcaaccacaa ggaattttct gttgaggcac 7980 ttttgttgtt tagtttagat cgcgttgctc tggttttttt ttttttactc aaatctcaag 8040 tgtgagaaaa acagcaggcg caccacacac aaacacacac acacatgcat gcacatatcg 8100 gatgtttaac atttaaatta gctgcttctg attggcattt tcggtatgac actgcttgca 8160 ttcagttctt tatgtgtggg tgtgtgtgtg tgtgtgcctt tgacgttttt attgcctaat 8220 cacttttttt tatttgcact ttactacgag aatactggac gaaaaccgct gactggaact 8280

39 atttttatgt ttgccccata atgtttttca accgaaaaat tgtatatttt ttttttacgt 8340 ctagtgtaaa caattgaaat ttatttactt cagggcataa acaaaatcgt tatacacaca 8400 cattgatagg eg 8412

<210> 23

<211> 2153

<212> DNA

<213> Drosophila

<400> 23 atggacagga gtcggagtag cagagctgcc agcagcaacc agttcatcag gccatgtggc 60 ctactgacga ccgtcatcct gctgcagacg cttgtgtcga tgagtttggc catcgaggag 120 atgtcgccac caccggccgc cccgccacgt ccatcgccgc cgcccaccgt gaagctcaac 180 aagtgctgcc attcgggcga gtatctgaac gatggcacct gcatcgccgg cagcgaagcc 240 ctgtggctgc ccatggtgta cttggtgcag cagcagcgct tcttcgagcc ccatggcgcc 300 agtccgcgat tcttgaagtt cctgcccaat acgagaccca cgtgccgaaa ggaccagacg 360 acggagatct ttcgcagccg cggagccaat gtgatgctct ttcccaatgg cacgctctat 420 gtgcgggaac gcgctctaat ggtccagccg tcggattact gtgtcgactg ggaggtggcc 480 gtcgtttgct tgaacgacag tcagccgatc aatgctctgg aggatcccga ttatgcagcc 540 aatcctctcg tgcagcagga gccgcccaag gctagcctgc gactgagcaa gtgctgcggc 600 aagtggggca gctataacac gcagctccag aactgcgatc tgcagcccaa ccatcaggca 660 gccgtcgatg gactgctgcg attgtcgccg cagctaccgg agggcagcta tcagactagc 720 tacggcctgc ccgactgtgg ccaacccggt ggctactcca ttgccggtga ttggcaggat 780 gccaagctgg atcggaacac ggccatgctc cagttgccgc acaagaacct cagcgccgga 840 caatactgcc tggagcacac gcagcgcgag ggcgaggtga agatcatagc ctgccagcat 900 ttgtttagct ccgcggcagg agccggcatc cacgacggct ccattggagg caccatcgag 960 caggccaatg gccagaatct gcagaaggcc gtcctgactg gtggcatact tgtgtccatt 1020 gtcttcctgt ccgccacttt ggtggccggc ttcctgctgc ccgctgtgca tcatgcgctt 1080 cattggcgct gccaaatctg ctatgtcacc tgcttgctat tcggcaaaat actgctggcc 1140 atcgaggagc tgagctccag cctgcagccg ggcagtgccg cctgccatac gcttgctatc 1200 accatgcagt tcttctttct ggccgccttc ttttggctga acaccatgtg cttcaacatc 1260 tggtggacgt tccgggactt tcggcccagt tcgttggaac gcaatcagga ggcactgcgt 1320 cgctatctgt actccctgta cgcttggggc ggtcctctgc ttatcacctt cgtggccgcc 1380 tgcgtggacc agctgccgga gacgacgcta ctgcgtccgg gattcggaca gctctactgc 1440 tggttcgaca atcgcaatct ctcgatcttc gcctacttct acggacccat tggcctgctg 1500 ctgtgcgcca atatagcgct cttcgtgtcc accacccatc agttgacgtg cggcctgtgg 1560 aaacgggacg atgtcaagtc ctcatcggag aagtccgccc tgggacgcgt ctgcctgaag 1620 ctagtcgtcg ttatgggtgt cacctggata gcggacattc tgtcctggct agtgggtgga 1680 ccgcatggcg tatggttctt caccgacctg atcaacgccc tgcaaggcgt cttcatcttc 1740 atcgtggtgg gctgccagcc gcaggtgtgg accgcctgcc gcaggatctt ctgtccgcga 1800 ttgcgtcatg acatcaccaa tacgaccaac ggtgtccagc attcgagcag ctcgcagggt 1860 ttgccctcga tggccggcgg cacggagatt acacagaaca ccaccaccac caccacgaca 1920 accaacacga ccgccactca catgcccagc aatccggcgg aggatgaggt accggagaag 1980 gctcccattg cccccgtcgc acccatcgtc aaaatggaga ccatttgcta aacacaactg 2040 agacgacgag cgacaatgcg aaagtcaggc ccggatacaa aagtccagac ctcgagcgag 2100 cgaaataatg gcaatgggca gctcagaaat aagaaagaaa gaatggaaaa aac 2153

<210> 24 <211> 676 <212> PRT <213> Drosophila

<400> 24

Met Asp Arg Ser Arg Ser Ser Arg Ala Ala Ser Ser Asn Gin Phe He

1 5 10 15

Arg Pro Cys Gly Leu Leu Thr Thr Val He Leu Leu Gin Thr Leu Val

20 25 30

Ser Met Ser Leu Ala He Glu Glu Met Ser Pro Pro Pro Ala Ala Pro

40 35 40 45

Pro Arg Pro Ser Pro Pro Pro Thr Val Lys Leu Asn Lys Cys Cys His

50 55 60

Ser Gly Glu Tyr Leu Asn Asp Gly Thr Cys He Ala Gly Ser Glu Ala 65 70 75 80

Leu Trp Leu Pro Met Val Tyr Leu Val Gin Gin Gin Arg Phe Phe Glu

85 90 95

Pro His Gly Ala Ser Pro Arg Phe Leu Lys Phe Leu Pro Asn Thr Arg

100 105 110

Pro Thr Cys Arg Lys Asp Gin Thr Thr Glu He Phe Arg Ser Arg Gly

115 120 125

Ala Asn Val Met Leu Phe Pro Asn Gly Thr Leu Tyr Val Arg Glu Arg

130 135 140

Ala Leu Met Val Gin Pro Ser Asp Tyr Cys Val Asp Trp Glu Val Ala 145 150 155 160

Val Val Cys Leu Asn Asp Ser Gin Pro He Asn Ala Leu Glu Asp Pro

165 170 175

Asp Tyr Ala Ala Asn Pro Leu Val Gin Gin Glu Pro Pro Lys Ala Ser

180 185 190

Leu Arg Leu Ser Lys Cys Cys Gly Lys Trp Gly Ser Tyr Asn Thr Gin

195 200 205

Leu Gin Asn Cys Asp Leu Gin Pro Asn His Gin Ala Ala Val Asp Gly

210 215 220

Leu Leu Arg Leu Ser Pro Gin Leu Pro Glu Gly Ser Tyr Gin Thr Ser 225 230 235 240

Tyr Gly Leu Pro Asp Cys Gly Gin Pro Gly Gly Tyr Ser He Ala Gly

245 250 255

Asp Trp Gin Asp Ala Lys Leu Asp Arg Asn Thr Ala Met Leu Gin Leu

260 265 270

Pro His Lys Asn Leu Ser Ala Gly Gin Tyr Cys Leu Glu His Thr Gin

275 280 285

Arg Glu Gly Glu Val Lys He He Ala Cys Gin His Leu Phe Ser Ser

290 295 300

Ala Ala Gly Ala Gly He His Asp Gly Ser He Gly Gly Thr He Glu 305 310 315 320

Gin Ala Asn Gly Gin Asn Leu Gin Lys Ala Val Leu Thr Gly Gly He

325 330 335

Leu Val Ser He Val Phe Leu Ser Ala Thr Leu Val Ala Gly Phe Leu

340 345 350

Leu Pro Ala Val His His Ala Leu His Trp Arg Cys Gin He Cys Tyr

355 360 365

Val Thr Cys Leu Leu Phe Gly Lys He Leu Leu Ala He Glu Glu Leu

370 375 380

Ser Ser Ser Leu Gin Pro Gly Ser Ala Ala Cys His Thr Leu Ala He 385 390 395 400

Thr Met Gin Phe Phe Phe Leu Ala Ala Phe Phe Trp Leu Asn Thr Met

405 410 415

Cys Phe Asn He Trp Trp Thr Phe Arg Asp Phe Arg Pro Ser Ser Leu

420 425 430

Glu Arg Asn Gin Glu Ala Leu Arg Arg Tyr Leu Tyr Ser Leu Tyr Ala

435 440 445

Trp Gly Gly Pro Leu Leu He Thr Phe Val Ala Ala Cys Val Asp Gin

450 455 460

Leu Pro Glu Thr Thr Leu Leu Arg Pro Gly Phe Gly Gin Leu Tyr Cys 465 470 475 480

Trp Phe Asp Asn Arg Asn Leu Ser He Phe Ala Tyr Phe Tyr Gly Pro

485 490 495

He Gly Leu Leu Leu Cys Ala Asn He Ala Leu Phe Val Ser Thr Thr

500 505 510

His Gin Leu Thr Cys Gly Leu Trp Lys Arg Asp Asp Val Lys Ser Ser

41 515 520 525

Ser Glu Lys Ser Ala Leu Gly Arg Val Cys Leu Lys Leu Val Val Val

530 535 540

Met Gly Val Thr Trp He Ala Asp He Leu Ser Trp Leu Val Gly Gly 545 550 555 560

Pro His Gly Val Trp Phe Phe Thr Asp Leu He Asn Ala Leu Gin Gly

565 570 575

Val Phe He Phe He Val Val Gly Cys Gin Pro Gin Val Trp Thr Ala

580 585 590

Cys Arg Arg He Phe Cys Pro Arg Leu Arg H s Asp He Thr Asn Thr

595 600 605

Thr Asn Gly Val Gin His Ser Ser Ser Ser Gin Gly Leu Pro Ser Met

610 615 620

Ala Gly Gly Thr Glu He Thr Gin Asn Thr Thr Thr Thr Thr Thr Thr 625 630 635 640

Thr Asn Thr Thr Ala Thr His Met Pro Ser Asn Pro Ala Glu Asp Glu

645 650 655

Val Pro Glu Lys Ala Pro He Ala Pro Val Ala Pro He Val Lys Met

660 665 670

Glu Thr He Cys 675

<210> 25 <211> 3187 <212> DNA <213> Drosophila

<400> 25 gaccagacaa gtgcaagcaa tggagctcag cgtcagtatc cactgtctca cacacatcca 60 caaaagcatc ttcatcagat tcagttcctc agatctcgca tcagctgctg cgattcccat 120 ggacgtgaca cggtggagcg gtggagaaaa catcatcata ataataataa agccgaataa 180 ctttctccac acgtagtgtg tgtcaataaa tcggttgttt ctcgcagagt ttgaaaggaa 240 acttttagag ttcttaaaca aagaatgtgg ttttggaacc actgtgccgc atcctgtctg 300 ccatgaatga tgcgtccttt cctgccagca cataaagccc cggccagttg catctattcc 360 acacactgat agacaatgtt tgtgcactga tttatactca gccagctatt aaataagaat 420 tttcgttatt acgctgccgg ggattttatt atgtgacttt caaaagcccc cgccaacttg 480 ttgtggcttt ggcttaaagc cgcgccaagc tgaaaattgt tattttaacc ttttaaagtc 540 agctttatca gcaccaaatg cagggccatt atgcgtggcc cacgcggcgt atgagcaacg 600 ttaaatctgc gaataattca aagacgtgcg tttcttttta cagccgcctt gtcggtaatc 660 ccattaagga gttatctggc gaaacatttt tgcacaacac tcgactggag gcactgtgag 720 tatactttgt ttgttttaat ttaaaaaatc acaaaatata tcatgaagtt gttaaaacgg 780 gattgaattt gatttgaata tatgatttca tttaatttct caccaatatt taagttcgtt 840 ggccctaatg ccgattcaca tcagcagcag tttaatggag ccactgaata tatcgttttt 900 gaatctcacg ggaattcggt atgatcacat cgacttcgag gccatcaatt caatgcgcaa 960 cctgacgtac atcatctacg atcgattctt ctactgctca atgacgccgc gggtgagaat 1020 gtgcaagccg tccaccgatg gagtcagctc ctttcaagat cttctgagca aaccagtgtt 1080 acgttactcc gcctgggtga tggccacgtt gacaatagct ggaaatgtgc tagtcctatg 1140 gggacgcttt atctaccgcg atgagaatgt ggctgtgaca atggtgattc ggaatctggc 1200 tctggctgat atgctgatgg gcttctattt ggtcaccatt ggagtgcagg actatcgcta 1260 ccgcaacgag tattacaagt aagtcaaatg tgatggattg gcatttgtta cgccccaatc 1320 ttttagggtt gtgctggact ggataacctc gtggcagtgc acactgattg gaacgctggc 1380 cgtgagctcc tcggaggttt cgatgcttat cctggctttt atgtcgctgg agcggtttct 1440 cttgatcgcc gatccctttc gcggccatcg cagcattgga aatcgggtga tgtggctggc 1500 tttgatttgc atttggatta cgggcgtggg cttggctgtg gcaccggtgc tcctgtggcg 1560 gaccagtacc ctaccctact acggatccta ttccggaacc tgtgagcaca atgtttatga 1620 taaaatgtag tttaccaagt gacgaaatta aacttaacag gctttccatt gcacatccac 1680 gaggccttcc cgatgggctg gctttactcg gctttcgtgt tcctgggcgt caatctgctg 1740 ctgctggtga tgattgcgat gctctacacg gcactcctta tttcgatatg gcgaacgagg 1800 agcgccactc cgctcactct gttggattgc gaattcgctg tgcgattctt tttcatcgtg 1860

42 ctgaccgact tcctgtgctg ggtgcccatc atcgttatga agatctgggt ttttttcaac 1920 tacaatatct ccgatgacat ctacgcctgg ttggtggtct ttgtgctgcc acttaactcg 1980 gcggttaatc ctctcttgta caccttcacc acgcccaagt accgaaatca aatcttcctt 2040 cgcggctgga agaagataac ttctagaaag cgagcggagg ctggcaatgg aaatgtggcc 2100 accacaacga cgggcacggc aactggatcc tctcagcatc cggatgactt cacgatcttt 2160 gccaaagccg cgatgagatg ccattaggtc ctaacgctgt cgaactgaag gattcttgtg 2220 gcgcagatcg aacttgtata ccaccagatt tagcagcatt tattttgtct atgatatcga 2280 aaatctatat atgtatgtga atatctatcc ctgtccgtgt aagataacca aatgaaagtg 2340 tgaaataaat tgaatgtgat atttgtaagg caattttacg gaatttaaaa tgggatgcga 2400 gttagtgtaa gattaagcta ttatctaagt tttggtaata gttttaaata ctttttattt 2460 agaaatagca gcgctatcat ttttggcatg gtgtgattct ttctggtccg agtaaatctt 2520 tgccattacc aacttggagc gcacgatgtg aaactttcgc atttcctcca ggtcctccat 2580 ctgcaccacc atgttatgct tacgctccag gtgcatgcgt agtctaaaaa attattaagg 2640 agtgttactt tcaaataatg tacactttaa acaaaataac taacttgtta cgagctggat 2700 agctctgatg gcagtgggcg cactcaaatg gcatggccgt atgcgtgcac tcgtgattcc 2760 tgagagatga agatgaggta aaggacttct ggcagccggg aaactcgcaa atgaagcgag 2820 atccagagtg cttaacctgc tggtggacag tcaaatggga tcgctgtgcg aaacgacgat 2880 cacagagatc acaggaatag ggaaagtctc tgttatgata gcgtttatga atctccaggg 2940 ctttggcaat ggcaaaaacc ttgccgcatg tgtcgcagtg gactccagac tgcctgtgct 3000 tcgaatcgac gtgaactttc agcgcctgct ttgtgaggta aacccggtcg cactggctgc 3060 aacgaaagtt gggacgattg gccaaatgaa tcatctggtg cttggccatg cgggaatggt 3120 tcctgaactc cttgtggcag aacttgcagt tggattttcc cgtatgccga ttgcgtggca 3180 caatgtc 3187

<210> 26 <211> 1080 <212> DNA <213> Drosophila

<400> 26 atgacgccgc gggtgagaat gtgcaagccg tccaccgatg gagtcagctc ctttcaagat 60 cttctgagca aaccagtgtt acgttactcc gcctgggtga tggccacgtt gacaatagct 120 ggaaatgtgc tagtcctatg gggacgcttt atctaccgcg atgagaatgt ggctgtgaca 180 atggtgattc ggaatctggc tctggctgat atgctgatgg gcttctattt ggtcaccatt 240 ggagtgcagg actatcgcta ccgcaacgag tattacaagg ttgtgctgga ctggataacc 300 tcgtggcagt gcacactgat tggaacgctg gccgtgagct cctcggaggt ttcgatgctt 360 atcctggctt ttatgtcgct ggagcggttt ctcttgatcg ccgatccctt tcgcggccat 420 cgcagcattg gaaatcgggt gatgtggctg gctttgattt gcatttggat tacgggcgtg 480 ggcttggctg tggcaccggt gctcctgtgg cggaccagta ccctacccta ctacggatcc 540 tattccggaa cctgctttcc attgcacatc cacgaggcct tcccgatggg ctggctttac 600 tcggctttcg tgttcctggg cgtcaatctg ctgctgctgg tgatgattgc gatgctctac 660 acggcactcc ttatttcgat atggcgaacg aggagcgcca ctccgctcac tctgttggat 720 tgcgaattcg ctgtgcgatt ctttttcatc gtgctgaccg acttcctgtg ctgggtgccc 780 atcatcgtta tgaagatctg ggtttttttc aactacaata tctccgatga catctacgcc 840 tggttggtgg tctttgtgct gccacttaac tcggcggtta atcctctctt gtacaccttc 900 accacgccca agtaccgaaa tcaaatcttc cttcgcggct ggaagaagat aacttctaga 960 aagcgagcgg aggctggcaa tggaaatgtg gccaccacaa cgacgggcac ggcaactgga 1020 tcctctcagc atccggatga cttcacgatc tttgccaaag ccgcgatgag atgccattag 1080

<210> 27 <211> 359 <212> PRT <213> Drosophila

<400> 27

Met Thr Pro Arg Val Arg Met Cys Lys Pro Ser Thr Asp Gly Val Ser

1 5 10 15

Ser Phe Gin Asp Leu Leu Ser Lys Pro Val Leu Arg Tyr Ser Ala Trp 20 25 30

43 Val Met Ala Thr Leu Thr He Ala Gly Asn Val Leu Val Leu Trp Gly 35 40 45

Arg Phe He Tyr Arg Asp Glu Asn Val Ala Val Thr Met Val He Arg 50 55 60

Asn Leu Ala Leu Ala Asp Met Leu Met Gly Phe Tyr Leu Val Thr He

65 70 75 80

Gly Val Gin Asp Tyr Arg Tyr Arg Asn Glu Tyr Tyr Lys Val Val Leu 85 90 95

Asp Trp He Thr Ser Trp Gin Cys Thr Leu He Gly Thr Leu Ala Val 100 105 110

Ser Ser Ser Glu Val Ser Met Leu He Leu Ala Phe Met Ser Leu Glu 115 120 125

Arg Phe Leu Leu He Ala Asp Pro Phe Arg Gly His Arg Ser He Gly 130 135 140

Asn Arg Val Met Trp Leu Ala Leu He Cys He Trp He Thr Gly Val

145 150 155 160

Gly Leu Ala Val Ala Pro Val Leu Leu Trp Arg Thr Ser Thr Leu Pro 165 170 175

Tyr Tyr Gly Ser Tyr Ser Gly Thr Cys Phe Pro Leu His He His Glu 180 185 190

Ala Phe Pro Met Gly Trp Leu Tyr Ser Ala Phe Val Phe Leu Gly Val 195 200 205

Asn Leu Leu Leu Leu Val Met He Ala Met Leu Tyr Thr Ala Leu Leu 210 215 220

He Ser He Trp Arg Thr Arg Ser Ala Thr Pro Leu Thr Leu Leu Asp

225 230 235 240

Cys Glu Phe Ala Val Arg Phe Phe Phe He Val Leu Thr Asp Phe Leu 245 250 255

Cys Trp Val Pro He He Val Met Lys He Trp Val Phe Phe Asn Tyr 260 265 270

Asn He Ser Asp Asp He Tyr Ala Trp Leu Val Val Phe Val Leu Pro 275 280 285

Leu Asn Ser Ala Val Asn Pro Leu Leu Tyr Thr Phe Thr Thr Pro Lys 290 295 300

Tyr Arg Asn Gin He Phe Leu Arg Gly Trp Lys Lys He Thr Ser Arg

305 310 315 320

Lys Arg Ala Glu Ala Gly Asn Gly Asn Val Ala Thr Thr Thr Thr Gly 325 330 335

Thr Ala Thr Gly Ser Ser Gin His Pro Asp Asp Phe Thr He Phe Ala 340 345 350

Lys Ala Ala Met Arg Cys His 355

<210> 28

<211> 3759

<212> DNA

<213> Droso;phil;a

<400> 28 cactcagatt tgcctgacacgc a<gaaatattt tatgggttgta tcttagatggt iggag;aaacat 60 cgaitgccaac atcgatgtt :a ttngatgtttt eg;aaaaatca aaaacgtt ;ga 'tgtttttcga 120 ggaatcgtcg atgttttcag c<gcat;agaaa cagcaaagtg tgt;aaattgt .aagtctaaat 180 taatttccat attttctaat acaattatta at;agcal :att gcaltatttat 'tgtg^;actcgc 240 cggtggtgta ggctggtgtc ttggaagaca tggataaata tct(gaaaltgt ,aagttttttt 300 ttt;aaagatc aatttatttg ttttttgcca aa<gacal :cga aaacatggat cgttcgccaac 360 atctgatgttt ctccacttct aatgccaacg aaaacgtgac tgggaactgta tcgal :gggaa 420 aaacgttaca aaaataccaa ctatcgcata getggaatcac cttggcgggc -tattcgaatg 480 tatctcacaa atagttttta atggaacctac agtcagtacc aaatacttaa iaattccattt 540 atattttatt ttatcgctaca g;aaaactgat aatgctgcatt acttttg;aaa ,agttaaaaat 600

44 tgtgtttttt aaatgattta tttatataaa taagcttatg taatactatt gttaatatgt 660 aaaaaaaaaa gaataaaaga aaaagaatag tttacctaag cagttgcttg aataatacat 720 acataattta agttttatac ataatttatc aaccctcgct cagtaggaaa aaaagatggc 780 tcagaaatga gcaacgaatt ggaatgtccg ataagccttt tttatcaaaa taataatttt 840 tacattccct tttcataacg ctttcccagt tagtttgtgc caatcgtaaa acagcatccg 900 caaagtgaag tcgctgctat tttgtagtac cactacattc ttatttattt aagtaatatt 960 taaagaatgt ccagctaact atatgattgc tagttcaaaa atgttacttt ctgcatcgat 1020 cctaatatat ttcttgctga atctgcaatc ttcgagtgct gagattgccg actgcagttt 1080 ctatgatacc gttgatatct cggaaggcca gaggctctcg aatggatcat acctctacga 1140 gggattactt attcccgccc atttgacggc caagtatgaa ttcaagcttc tggcgaatgg 1200 agataaggag caggtgccaa gtcacgtgag aggatgtgtg tgcaagctaa ggacttgcgt 1260 caggttttgc tgcccacatg accacataat ggatatgggc gaatgctacg ccaacatgac 1320 gacggaggag aacgaattac tggaccccat gctaaatgtg accctggacg acggatcagt 1380 ggtgcaaagg cactataaga aggagctcat ggtgcagtgg gatctgccaa agccctgcga 1440 tgatatgttt tacctagaca accgggatat aatggatgag tacaccttgt tcgaggtatg 1500 gctgctcgaa aaataagcat ttttgggcag gatttattta tgctttggct ctctgcagaa 1560 tggaagattg ctgcgccact acgatcaagt gtatttggac aagtcggagt actgtctgca 1620 gcaccgaaca ttcggcgaag gtaacaacaa ctccattcgc attatacccc acaactgctt 1680 gatactgcca tccagaacgg gacagaccgt tggtaagatg atgcccattg cttgcatggt 1740 agctcccagt tctatatctt tcctatttcc atagtgatga tcacatcgtt gatatgcttg 1800 gttcttacca tcgccgtgta cctgtgcgtt aagaagctaa tgaatttgga gggcaagtgt 1860 ttcatctgtt acatgatgtg cctatttttc ggatacctgt tcctactcct tgatctgtgg 1920 gagttatcgc tcgatttctg taaagcagca ggttagctta gaggggatgc atttcaacac 1980 aacttgacaa accattgacc atttacgaca ggtttcttgg gatacttttt cgtcatggct 2040 gcgttctttt ggctatctat catcagtcgg cactattgga aatgtcttac caatccctgt 2100 gcctcgatga acattcggtc agaacgtgcg tttctgctat acagctgctt cgcctgggca 2160 atgcctttgg ccttgaccgg agtcacctat ctggctgata acgttgtgaa caacgaggag 2220 tggcagcctc gcgtgggcga cgaagggcat tgctggatct atagtgggtt ctgttttgta 2280 tccggcttgt ggtaccagct caccaatgtt tttctttcca ccctcagcta aaagctggtc 2340 tgcaatggtg tacttctatg gaccgatggt gctcctgatt ctcttcaaca taactatgtt 2400 tgttctgacg gctaaacaca taatagattc caagaggact cttcgaaaga ttgctcgcaa 2460 tgaaggtaga atacagaagc tgaattcgga caaacagaag tatatcaatt ataatagttg 2520 aaaatgtcag tttaagataa atattatcaa ttcgttacag ttacacacaa tttctgctgc 2580 tcttcactgt gatggggatg tcgtggagct ttgagatatt ctcctacttg gtgcaacgcg 2640 agaaactgtg ggtcaatatc tttctggtag ctgactactt caactggtcc caaggcgtca 2700 ttatatttgt gctattcatt ctgcggcgca aaactcttgt actattcaag aaacagtaag 2760 tcttatagtt catagttcgg gtaaccagtt ccctaaaatg tctcttttca gaatatttcc 2820 caaacagaga gcctttagta gatctgcaac tcaaagtacg attgaatcca tttctcaaac 2880 aaaaaggcat tttaacatga catagtattt tcttctcttc gaattaatca atttaatagt 2940 aaagtataac tttttttctc acaaaatgta tgaatatatt tcacttcatt ctacattcta 3000 tatagaattc atttaatcac aaaatgtatg aatatttttc tttatatgac gtgcatcgac 3060 tatagaaaat cgactatagt gtgccacaat atattttact catcatttcc taatcaaact 3120 attgcaaact taactttgag ccgaggaaaa accctgtatg tctatcaaaa ctatgagtca 3180 aaagtatgac gcgatgctga aagtagttgc ctttaaatat tgaagtgata aatgtagaaa 3240 gaagacattt gtatggaaat aaactaagtt tgtaaatcta cattcgcttt atttcatgta 3300 caaattttaa tttaaaaact ttgaaggtaa atagtgcttt atcagatgcg gattacacgg 3360 tagcagttat catcgatgtc gaatcttctt gtttatgtga ccgcttttct tcgctgtcgc 3420 actggagttc gtggatagtt tgctctttgt attcgaagtg ggtgtgccga ggagatcctt 3480 gttccctcca ctgttcgtag atccagacac cattccgctc actacgctgc cctcattgcg 3540 atgcgagggt gaatctgtaa ataaaaaggt gtaattaaac atatatactt ttctggagaa 3600 aagcgctaaa gttgaatctc aatgtgctgt gctgccttac ccttttcgtc tttcggtgtg 3660 ctcttgattg tcgtggttcc gtcgtgggcc gttgtggtgt tctgattgat tgagatctga 3720 ttgtcgctgg agtcttcatt tgtgatggaa tccgattcg 3759

<210> 29 <211> 1449 <212> DNA <213> Drosophila

<400> 29

45 atgttacttt ctgcatcgat cctaatatat ttcttgctga atctgcaatc ttcgagtgct 60 gagattgccg actgcagttt ctatgatacc gttgatatct cggaaggcca gaggctctcg 120 aatggatcat acctctacga gggattactt attcccgccc atttgacggc caagtatgaa 180 ttcaagcttc tggcgaatgg agataaggag caggtgccaa gtcacgtgag aggatgtgtg 240 tgcaagctaa ggacttgcgt caggttttgc tgcccacatg accacataat ggatatgggc 300 gaatgctacg ccaacatgac gacggaggag aacgaattac tggaccccat gctaaatgtg 360 accctggacg acggatcagt ggtgcaaagg cactataaga aggagctcat ggtgcagtgg 420 gatctgccaa agccctgcga tgatatgttt tacctagaca accgggatat aatggatgag 480 tacaccttgt tcgagaatgg aagattgctg cgccactacg atcaagtgta tttggacaag 540 tcggagtact gtctgcagca ccgaacattc ggcgaaggta acaacaactc cattcgcatt 600 ataccccaca actgcttgat actgccatcc agaacgggac agaccgttgt gatgatcaca 660 tcgttgatat gcttggttct taccatcgcc gtgtacctgt gcgttaagaa gctaatgaat 720 ttggagggca agtgtttcat ctgttacatg atgtgcctat ttttcggata cctgttccta 780 ctccttgatc tgtgggagtt atcgctcgat ttctgtaaag cagcaggttt cttgggatac 840 tttttcgtca tggctgcgtt cttttggcta tctatcatca gtcggcacta ttggaaatgt 900 cttaccaatc cctgtgcctc gatgaacatt cggtcagaac gtgcgtttct gctatacagc 960 tgcttcgcct gggcaatgcc tttggccttg accggagtca cctatctggc tgataacgtt 1020 gtgaacaacg aggagtggca gcctcgcgtg ggcgacgaag ggcattgctg gatctatact 1080 aaaagctggt ctgcaatggt gtacttctat ggaccgatgg tgctcctgat tctcttcaac 1140 ataactatgt ttgttctgac ggctaaacac ataatagatt ccaagaggac tcttcgaaag 1200 attgctcgca atgaaggtag aatacagaag ctgaattcgg acaaacagaa ttacacacaa 1260 tttctgctgc tcttcactgt gatggggatg tcgtggagct ttgagatatt ctcctacttg 1320 gtgcaacgcg agaaactgtg ggtcaatatc tttctggtag ctgactactt caactggtcc 1380 caaggcgtca ttatatttgt gctattcatt ctgcggcgca aaactcttgt actattcaag 1440 aaacagtaa 1449

<210> 30 <211> 482 <212> PRT <213> Drosophila

<400> 30

Met Leu Leu Ser Ala Ser He Leu He Tyr Phe Leu Leu Asn Leu Gin

1 5 10 15

Ser Ser Ser Ala Glu He Ala Asp Cys Ser Phe Tyr Asp Thr Val Asp

20 25 30

He Ser Glu Gly Gin Arg Leu Ser Asn Gly Ser Tyr Leu Tyr Glu Gly

35 40 45

Leu Leu He Pro Ala His Leu Thr Ala Lys Tyr Glu Phe Lys Leu Leu

50 55 60

Ala Asn Gly Asp Lys Glu Gin Val Pro Ser His Val Arg Gly Cys Val 65 70 75 80

Cys Lys Leu Arg Thr Cys Val Arg Phe Cys Cys Pro His Asp His He

85 90 95

Met Asp Met Gly Glu Cys Tyr Ala Asn Met Thr Thr Glu Glu Asn Glu

100 105 110

Leu Leu Asp Pro Met Leu Asn Val Thr Leu Asp Asp Gly Ser Val Val

115 120 125

Gin Arg His Tyr Lys Lys Glu Leu Met Val Gin Trp Asp Leu Pro Lys

130 135 140

Pro Cys Asp Asp Met Phe Tyr Leu Asp Asn Arg Asp He Met Asp Glu 145 150 155 160

Tyr Thr Leu Phe Glu Asn Gly Arg Leu Leu Arg His Tyr Asp Gin Val

165 170 175

Tyr Leu Asp Lys Ser Glu Tyr Cys Leu Gin His Arg Thr Phe Gly Glu

180 185 190

Gly Asn Asn Asn Ser He Arg He He Pro His Asn Cys Leu He Leu

195 200 205

Pro Ser Arg Thr Gly Gin Thr Val Val Met He Thr Ser Leu He Cys 210 215 220

46 Leu Val Leu Thr He Ala Val Tyr Leu Cys Val Lys Lys Leu Met Asn 225 230 235 240

Leu Glu Gly Lys Cys Phe He Cys Tyr Met Met Cys Leu Phe Phe Gly

245 250 255

Tyr Leu Phe Leu Leu Leu Asp Leu Trp Glu Leu Ser Leu Asp Phe Cys

260 265 270

Lys Ala Ala Gly Phe Leu Gly Tyr Phe Phe Val Met Ala Ala Phe Phe

275 280 285

Trp Leu Ser He He Ser Arg His Tyr Trp Lys Cys Leu Thr Asn Pro

290 295 300

Cys Ala Ser Met Asn He Arg Ser Glu Arg Ala Phe Leu Leu Tyr Ser 305 310 315 320

Cys Phe Ala Trp Ala Met Pro Leu Ala Leu Thr Gly Val Thr Tyr Leu

325 330 335

Ala Asp Asn Val Val Asn Asn Glu Glu Trp Gin Pro Arg Val Gly Asp

340 345 350

Glu Gly His Cys Trp He Tyr Thr Lys Ser Trp Ser Ala Met Val Tyr

355 360 365

Phe Tyr Gly Pro Met Val Leu Leu He Leu Phe Asn He Thr Met Phe

370 375 380

Val Leu Thr Ala Lys His He He Asp Ser Lys Arg Thr Leu Arg Lys 385 390 395 400

He Ala Arg Asn Glu Gly Arg He Gin Lys Leu Asn Ser Asp Lys Gin

405 410 415

Asn Tyr Thr Gin Phe Leu Leu Leu Phe Thr Val Met Gly Met Ser Trp

420 425 430

Ser Phe Glu He Phe Ser Tyr Leu Val Gin Arg Glu Lys Leu Trp Val

435 440 445

Asn He Phe Leu Val Ala Asp Tyr Phe Asn Trp Ser Gin Gly Val He

450 455 460

He Phe Val Leu Phe He Leu Arg Arg Lys Thr Leu Val Leu Phe Lys 465 470 475 480

Lys Gin

<210> 31 <211> 4469 <212> DNA <213> Drosophila

<400> 31 acgttgtcag tgtgtgtgac ggttgttaat ttcatttgac ttgcgagggt tttaatattg 60 caatggaaat tcggtacaat ttgccgtcca ttaaataagc acgcaattaa ttgtggcagc 120 catgacaggc gtggcttgcc accaattaag tggaatacta tatggctata tcgctatatc 180 gctatatgtc tatatggcat atagatgccc acagcccctt ggggtcgatc gcctacgccg 240 tctataatcc ccagctaaac ttcgagacat cgcatccggc accgcaatcc gaaatcggaa 300 tgctgatgag gcaacagagt ggacgcggcc ggaaacaagg cactcctccc atcaatctgt 360 cagacgggcc agtgagtcct ggatgtcctg gtgaacgcag ctcagctccc agcgggtgag 420 gccagttgcc cagacagtta gtccgccagg cagtcagtcg gtctgtcagt gagtcagtta 480 gtcagtgagc gagtgagtca gtcagtcaat cgaacaatca atcatacgga atgacagcta 540 cgtcggctta agtcaaaggc agtcggccaa gaagggatct tgtctaactt acagtcgcaa 600 aattcaatag cctgtggcaa tcgcacttgc aactttaata attccaagaa cgaagcagtc 660 ataatgttta ctgaaataat gttatgccac aattggcaca tacaagctca taatagtgtt 720 ttattctgtt tttaattgca ctttaaaatt gatgattgta ttagccatca taggcatggc 780 ttgagctgtt catttagcca tttgattttg tctacgttgg ttttttatca agtttcttgc 840 cgtgtaacct tttttttttt tttgggctct cccaacaatt tgagctcctt tttcgttttc 900 gcattccctt aaacatttgc tggggaaaca cattgattta tatgccggca tcgccaaaaa 960 ttgaatgtta ttgcttgaat ggccccaatt tacttaaaag ctacgctcct ccgccccact 1020 gcccctctgc cgctccactg acccctgacc ccattataca tgttgtgggc tccactggct 1080

47 cctgattggt atttatgagc gtgtttattt attatatgac ccaacacttg ataaaattaa 1140 acggaaatgg ttggcaattt tgcatttgat tctgacaccc aaacacacag gcaggcaaat 1200 tcgcaaatga actcatctgc ccaatattcc gaccataaag catcccgacc aacggcactc 1260 acatataagt tagttaagta tgtatattag tggcttggca acttaccaga aagtagacag 1320 caaatggcat cacgaccacg gcgaccagga gatcggcgat ggccaacgag actataaaat 1380 aattcgtgac cgtctgcagg gagcgctcgc ggcacacgga caggatgacc aggatgttgc 1440 cgaagagggt caggatgggg aacagaatca ggatgagcgc ccagtagttg tggtccactg 1500 aaacgaagcg agttgtagtt acattatatc cgggatgcat ccatccgcag gctctcctgc 1560 tgctgccacc caaattccct ggccaaagtt caccttgcag gaagatttca gggaaagctc 1620 aacgggcacg taagtcaatt acacaggcag tccgtttaat caaggactct ggctgacaac 1680 taattttaat ggcaacacaa gtaaggacta gcacacaaag acgtgaatct taaaggctgt 1740 tttaatataa tctatctaat atagagtgat gcatgttacc aacagctgcg ttgttaaaaa 1800 ttaaagttat ttcacatatt aaaaatggca aaatatggct atgtaatatg aaagttatta 1860 aacttgaaat acctttatct tcattatgaa acaaattaaa caaacaaata tgtaggaact 1920 tttcttgaga ttgcacgaat aaatgagtta tgtaacgcgt ttaaattaaa ttcttgctat 1980 caaaactgat ttctaaatga acatctttat aaataaatta attatcggcg gtttcattca 2040 aatactccca tcttagaaat ctaaggaatt ctgttctcaa aacctagtca cctcactatc 2100 cgatgaaaat atattatact aaagaagttg ctgttgcaag gtttaaatga tgctccaact 2160 tgatgataat gtttaaaggt atttaatgag attcaaggct atctaatcta atttaataat 2220 tttaaagcct ttgaatgata ttcaataata tctaatgagc tttaatgatt tttaaagatt 2280 tataatgcgg ttttaagatg ttaagttgta gtagtttgat gatttcgaat ggtaatcctg 2340 cctcgtactc acccactctc agctcgccgc aggagtcggt taggttgagc gtctcgttgg 2400 tgcagttcag ccggtagccg tcgaggtaca gtcccgtcag gttctgctcg aggagcagtc 2460 cgctgcccct gctccccgtg atggccactc ccggcgcaat ggtgcttgtt cccgaaaccg 2520 tgctcccatt gtagttggga aaataatcgt taaagttttc gagcagcagc atgaaggtgc 2580 tgccccctga tcctccagcg ccgcctacac ctccgcccgc cgtaccggcc agtccgccag 2640 ccacgcccac atccccagag ccgcctccat cgtaactggt cgtcgagggc gccgttcgat 2700 tgcccagcgt ctcgcgcgcc accgttgctg tccgctggag cagttccgca tcaccgaagc 2760 cgcccagcat gccatagtcc gtttccgcat cagccacatt gtccagggct gcctcctccc 2820 cgctgtcgat cagcgcgatg ccagcatcgc cgccgtcgcc cgctcctgct gcccctccgc 2880 ccgccagctg ttgttccaca aagctgcgca gcgagtaacg cccccgctca ccatcctccg 2940 cactggagtt gctctgggct ggctgcgtgc tgttcagtgc ctccagccag gccagggttc 3000 cgttggcgcc cgtcaccgcc aagtttgtgc tgttctcggg cccgcccact gccgcctcac 3060 tgcccaccga acccaagagc cattcgctga tgtcgtcgat cagcgcgtag ccggcgtcct 3120 ccgccgccgt ttccacatcc tcgtagagcg gcaagtagcc ggctggcatt gtggggccct 3180 caacgcccgc ctgcgcatcg ctgccgttcg ccggttgaga gctgtccgct tccaccgcca 3240 ggtggtgatt tatccacgtg gctcccgcgg atggggctgc cgtggtcgag gtggaagcag 3300 cggctgtgct caaggtcgcc gatgtggttg ctgccgttgc tgcagttgcc gcagttgctc 3360 ccgttgccgc cgcagttgtt gccgccgtgc tgctcagtgg ctgggctgcc atggtgccgc 3420 cggttccgct gctgctgatg ccccgccgcc aatcgaatgg gctcaacatc tagtggggcg 3480 ggggcgtggc agcggaggcg agctgcaact cctgcaacgc cagcggcatg tttccgtttc 3540 ctgcagcgaa agagacgaag ttcggaggtg agaaaacata aatcacaaaa atttccatta 3600 taatcaaagt tcttgaagat agttcttaac gatacgcaca actaagatta caattttaag 3660 cctaattggt cgcgttaatg ttgcttaatt tgataaattc ttgtaatccg caaatgagag 3720 tcatggttct tttcgactta atatttttag gatatctaaa aaacaaagtc gttctcaatt 3780 tttcctactt acacattaca cattgcatgc cccttcgttt gcattttcaa cacaaggcgt 3840 acttcatgct tgaccacgcc cccccaacca acacaacaac ataccatcca gcaccacgcc 3900 cccatgccat tttggacgta cggacccttt gcccaactgc catggccgca tgtttaatta 3960 actctttaat caatttattg tcaattattc tacaaaaagc gacagcgaaa attgtgtaat 4020 ttaattaaat tagcaaaagg tttttgtgtc tctctcgccc caccaaccat tccgcccact 4080 cccacttcca ttctcgcaac caaaatgcca cgcccccatg ctcgacgctg tcttgctttt 4140 acacattttg caattttcgc ttttgtattt gccaattggc gctgattaaa gccgcccgag 4200 tcgatgggcc ataattaaaa gatggcctaa tgagaggcga ggcgagtacg tctcgagttg 4260 gctgggggtc aaaggtaatc ggatcggagt ggtcttaagt cccctgcctt ctgcctctgt 4320 cttccggaga tcgggttatt cgaactctga gcttgtggat tctggactct gaattctgga 4380 ttccggatcg gaggcagaga tccgagagct gcacacccag acggctggca ctaatccaat 4440 ttgggcacac ttccaggcga cgagaggca 4469

<210> 32 <211> 1389

48 <212> DNA

<213> Drosophila

<400> 32 atgttgagcc cattcgattg gcggcggggc atcagcagca gcggaaccgg cggcaccatg 60 gcagcccagc cactgagcag cacggcggca acaactgcgg cggcaacggg agcaactgcg 120 gcaactgcag caacggcagc aaccacatcg gcgaccttga gcacagccgc tgcttccacc 180 tcgaccacgg cagccccatc cgcgggagcc acgtggataa atcaccacct ggcggtggaa 240 gcggacagct ctcaaccggc gaacggcagc gatgcgcagg cgggcgttga gggccccaca 300 atgccagccg gctacttgcc gctctacgag gatgtggaaa cggcggcgga ggacgccggc 360 tacgcgctga tcgacgacat cagcgaatgg ctcttgggtt cggtgggcag tgaggcggca 420 gtgggcgggc ccgagaacag cacaaacttg gcggtgacgg gcgccaacgg aaccctggcc 480 tggctggagg cactgaacag cacgcagcca gcccagagca actccagtgc ggaggatggt 540 gagcgggggc gttactcgct gcgcagcttt gtggaacaac agctggcggg cggaggggca 600 gcaggagcgg gcgacggcgg cgatgctggc atcgcgctga tcgacagcgg ggaggaggca 660 gccctggaca atgtggctga tgcggaaacg gactatggca tgctgggcgg cttcggtgat 720 gcggaactgc tccagcggac agcaacggtg gcgcgcgaga cgctgggcaa tcgaacggcg 780 ccctcgacga ccagttacga tggaggcggc tctggggatg tgggcgtggc tggcggactg 840 gccggtacgg cgggcggagg tgtaggcggc gctggaggat cagggggcag caccttcatg 900 ctgctgctcg aaaactttaa cgattatttt cccaactaca atgggagcac ggtttcggga 960 acaagcacca ttgcgccggg agtggccatc acggggagca ggggcagcgg actgctcctc 1020 gagcagaacc tgacgggact gtacctcgac ggctaccggc tgaactgcac caacgagacg 1080 ctcaacctaa ccgactcctg cggcgagctg agagtggtgg accacaacta ctgggcgctc 1140 atcctgattc tgttccccat cctgaccctc ttcggcaaca tcctggtcat cctgtccgtg 1200 tgccgcgagc gctccctgca gacggtcacg aattatttta tagtctcgtt ggccatcgcc 1260 gatctcctgg tcgccgtggt cgtgatgcca tttgctgtct actttctgga gccagtggag 1320 cccacaacat gtataatggg gtcaggggtc agtggagcgg cagaggggca gtggggcgga 1380 ggagcgtag 1389

<210> 33 <211> 462 <212> PRT <213> Drosophila

<400> 33 Met Leu Ser Pro Phe Asp Trp Arg Arg Gly He Ser Ser Ser Gly Thr

1 5 10 15 Gly Gly Thr Met Ala Ala Gin Pro Leu Ser Ser Thr Ala Ala Thr Thr 20 25 30

Ala Ala Ala Thr Gly Ala Thr Ala Ala Thr Ala Ala Thr Ala Ala Thr

35 40 45 Thr Ser Ala Thr Leu Ser Thr Ala Ala Ala Ser Thr Ser Thr Thr Ala

50 55 60 Ala Pro Ser Ala Gly Ala Thr Trp He Asn His His Leu Ala Val Glu 65 70 75 80 Ala Asp Ser Ser Gin Pro Ala Asn Gly Ser Asp Ala Gin Ala Gly Val

85 90 95

Glu Gly Pro Thr Met Pro Ala Gly Tyr Leu Pro Leu Tyr Glu Asp Val 100 105 110

Glu Thr Ala Ala Glu Asp Ala Gly Tyr Ala Leu He Asp Asp He Ser

115 120 125

Glu Trp Leu Leu Gly Ser Val Gly Ser Glu Ala Ala Val Gly Gly Pro

130 135 140 Glu Asn Ser Thr Asn Leu Ala Val Thr Gly Ala Asn Gly Thr Leu Ala 145 150 155 160 Trp Leu Glu Ala Leu Asn Ser Thr Gin Pro Ala Gin Ser Asn Ser Ser

165 170 175

Ala Glu Asp Gly Glu Arg Gly Arg Tyr Ser Leu Arg Ser Phe Val Glu 180 185 190

Gin Gin Leu Ala Gly Gly Gly Ala Ala Gly Ala Gly Asp Gly Gly Asp

49 195 200 205

Ala Gly He Ala Leu He Asp Ser Gly Glu Glu Ala Ala Leu Asp Asn

210 215 220

Val Ala Asp Ala Glu Thr Asp Tyr Gly Met Leu Gly Gly Phe Gly Asp 225 230 235 240

Ala Glu Leu Leu Gin Arg Thr Ala Thr Val Ala Arg Glu Thr Leu Gly

245 250 255

Asn Arg Thr Ala Pro Ser Thr Thr Ser Tyr Asp Gly Gly Gly Ser Gly

260 265 270

Asp Val Gly Val Ala Gly Gly Leu Ala Gly Thr Ala Gly Gly Gly Val

275 280 285

Gly Gly Ala Gly Gly Ser Gly Gly Ser Thr Phe Met Leu Leu Leu Glu

290 295 300

Asn Phe Asn Asp Tyr Phe Pro Asn Tyr Asn Gly Ser Thr Val Ser Gly 305 310 315 320

Thr Ser Thr He Ala Pro Gly Val Ala He Thr Gly Ser Arg Gly Ser

325 330 335

Gly Leu Leu Leu Glu Gin Asn Leu Thr Gly Leu Tyr Leu Asp Gly Tyr

340 345 350

Arg Leu Asn Cys Thr Asn Glu Thr Leu Asn Leu Thr Asp Ser Cys Gly

355 360 365

Glu Leu Arg Val Val Asp His Asn Tyr Trp Ala Leu He Leu He Leu

370 375 380

Phe Pro He Leu Thr Leu Phe Gly Asn He Leu Val He Leu Ser Val 385 390 395 400

Cys Arg Glu Arg Ser Leu Gin Thr Val Thr Asn Tyr Phe He Val Ser

405 410 415

Leu Ala He Ala Asp Leu Leu Val Ala Val Val Val Met Pro Phe Ala

420 425 430

Val Tyr Phe Leu Glu Pro Val Glu Pro Thr Thr Cys He Met Gly Ser

435 440 445

Gly Val Ser Gly Ala Ala Glu Gly Gin Trp Gly Gly Gly Ala 450 455 460

<210> 34

<211> 11501

<212> DNA

<213> Drosophila

<400> 34 tttgtaccgc agtcaagcgc aaaaattcct cgaaaaacca tagaccaagg tgtttatgag 60 tttattaata ctgtgtaatt attatttgtg atatatgtgt gggaaattgg taatagatca 120 aacatgaaag taatggtatc tgtttttctg tattaaaata acatatctga taatttccta 180 aaggatgtta atgttaattt aataggtatt ccaaaactaa gagtgaactg gcaaaatgta 240 aaattagttg gtatttcctt ttgaataagc ttgaccttta acttacttca tagcctatga 300 caactcatat attataaata taaataataa taaatgagtg ctaataataa tttttaatca 360 aaaattctca caagctaacc ttgtaatgat ggtacgccta actgataccc attatgttac 420 catggccagg cataaattcc tgttactggc accgcatcat catcatactg gcattcggtc 480 atattaaaat aatatcacct atctataggg ctgcggctct tttgacacgc acacgtgctg 540 ctcagcagac caagtgaact tatcaatgaa cacccgccac acccacacgg tggcccaagc 600 acctgaccca cccatgccca gtggccagca ccacccgaac tcgcagaagc caatgaatgg 660 ccggcagacc aagaaacacc cactaacatc tcgggagatt cttcgtctgc cgagttcaag 720 aacaacacac aagtggccgt aatgaaatgt gaatagcctt ggcaaacatg agtccggaaa 780 gccaacttat gatggcttct gaatagccaa ccgcatagta cacggctaag agcggggacc 840 aaaaaaggac ctgctctttg ctcgctcgtt ggctttctct ttcgcagcct cggctcggaa 900 aaaggatgcc gacaagcaac aattttcatt gataaaaaca ccagctgctg ggtcctgaaa 960 ctcagtcgta cgcgagtcct cagtcagtca gtttcgagct ctgggatgca acggatgcgg 1020 atgccttaaa tccccgagcc gtttggcggt gttattgaaa attgcgtatt cgccgcgtat 1080 taccaagtaa tagcttgtcc aaagccacta cgctgtcaaa ggacgggctt aaaacgctac 1140

50 ttgcattttt acgtactata catagataaa ttttccgggt aatcggcgga aattgagtta 1200 aagttttgtg tccggttggc gccagttggc aattggtgct ggccaacttt cggacccgaa 1260 cgatgacaaa ctgaaaagta aactttgtaa agactcagca ccttacaaac aaattcaagt 1320 gtttcgcgaa aaaaaataaa aaattttgaa ttgaagagga cacagttcgg tgaaaaaaaa 1380 atatttgcaa tgcacaatgg aaaatcagca aagtgacctc caagtttacg aaaacagaaa 1440 ctaactcaat aaccatccct gcaggtgagc agaggcaaca ttttttcttt aaaacatttt 1500 ttaccatatt tccgtaaacg gtttgcgtcc tttggcaaat ttatggttgt cttggaataa 1560 aatgaacttt atttacttgg caacaaaacg agtgtttatt cttgtcgcat agggaatcaa 1620 gcagccaaca taaggactat attttgttta attcgattta atgtgagttg cagaattaaa 1680 tttcttttta attcaacacg catctgtaca ccatttgtaa aattacaagc taaagctcag 1740 caaacactaa attttaatca gtgaaacgaa ctgtattctg tcaattttaa tatcaaaagc 1800 atatacattg ctcttaaaaa tattaaactg cgttagtaac gtaaacagaa aatgctatga 1860 aatttgttat aatcaaaatt cacttgaaag agatttcaac aaaattacca atctcgtgtt 1920 ctaaggaatt aatataataa ttataataat atcatagctt gttccctgtc acctaatata 1980 taccatttaa ataaaagtaa tgcctaggta attgtttgtg agcgataagc gcagatttgt 2040 ctgcataatt atgtgttaat ttgattgagg tctactgaag agggccttat ttttataagc 2100 caaaagaaca aattcaaaca aaacacttga gggcggcctt agctggcaat aagcggcttt 2160 tgcctaatgg aaaataagtg gaatgcctag gaattattgg ccaagtggac gggctgctct 2220 ctttctggca atcctgagtc ctttcgactg attcgttttt ggctcctttg gccccatctc 2280 cgcacgcttt gttcggcttg acacacctga gtggcgatgt tccacacagg cactttccca 2340 aacaaatgga acccggcatc tcgcatttgg ttgcccgaac gtaagtccca tgaagtggtc 2400 ttctccagtg gacagccagt cagccgcatt tcttgggggc gctcttctcg agcgcttggc 2460 ctctgagatg gcctctttgg atgtcttgga gatatgcagc tcatcctggc cacccacttc 2520 gccgagccat tccatttcat ttccctggcc aacatacccg tatgaaacga tgagtgctct 2580 tcacagtttt tgcctacatt ccggccactg caccgactga tggttgatgg agacccattc 2640 tccggttagt gttcgtcttg gtcgtcttgg tctgggtctc ggtcctggtc acaatgggaa 2700 ttcgcagctt aaaggcgccg tggctttatt caggccagat tggatacttg acatgttcta 2760 atgcggcgca gatctcagtt tctgcaacgt gctctcccta tctcagttac atgaattagc 2820 attcatcgcc actgcactga gcaaaaaata ggaccacaaa tcgctctaac tgctgtaaat 2880 tgatatccat tcaattattt tatttaagta ttataacaca ttgatagaac attaacatgt 2940 catatatttt tgaacacaat tcagcattac actttaataa agtcgaattt gaatttatcc 3000 aactgacgcg ttgggtgata tcataaattc aatttcgaga atgacaggtc attaaaatgt 3060 tgtcacctac actgtcaaat atttaagtca aaatattaag ttataaaata tcaaaaagct 3120 ttgatagctt tagagtatga tttacgttta aaaggattgt acacgaatac aattttgttt 3180 ttttaagcaa tcagcggcgt gtttctgttt tgccatcata aatcgcagag tttcataatc 3240 cctctaaatt aaaatgtcct ttgggatttt tctgaaattt ttttcaaacg cttccccctt 3300 tttgtttcct gcatgtttag gccgttaaga gcctgttgat gatggcggca tggtagaact 3360 ttctgttttg tcacagcctt gggctgctgg ctttacattt ggtggaaaaa cgagaccagc 3420 cgagcacgtg cggtccgcgg ggttgggggg ggttgtggaa gctaaggacg tggcaggacg 3480 aaagcgctga gtgcagatga ggactgcaat aaactgccat acataagtga aaattgtgaa 3540 atgaaaactt gcgcgagcat aaatcaatac acccaagggg ggtcatgggc tcccatggca 3600 ggcaacaaaa aaatatatat gtatatatat cagctgggaa atgtgctccc tactcaggtt 3660 tagcgacttg tatttcatgt tcccaaatca gctggtgtta tcctttgatt gccgggcaca 3720 cgacaaaagt ggtggaccag gacacatgtg atgattgctt gcgtgggtcg caggaatgag 3780 ccaactcaga ttggtaatat tgtgtatgaa cgtgatttcg tgactttgca atgtttctat 3840 ttaacaaaaa ctcttgttaa agaaatacac acaaaacatc acttataacc ctttttggat 3900 atctatgagg atttaaggtt tgtaaactaa ggcaatggta taccttaaaa agtctatagt 3960 aaatcgcata tattacatca attttaacgt tcatgctgat cttccagttc caaaatatat 4020 attttgaaat agcttacatt taattaagtg cacttgctat aaaagttttg agcttgcctg 4080 aagtttatta cataaaaaat tcgcagaaag gcggctaaag aatgaaacta atttaagccc 4140 aaatgataaa ctatttgcca agcatgtttc gtttgaatta tgctcccgtt gctctgccta 4200 ccaaaaatgg caaaaactcg caatatgatt attgtggcag cttcttccgg tgaattaaaa 4260 atacaaaaaa ccagctcaaa ttgaaactta attttaataa attgttttca tgctcttttt 4320 cgctgccgtt gtagcgtttt cccgcccatt tcacccgagt ggctggataa ttgtatccgc 4380 gcaatcatcc cgcggcttcc attgccgcag gataaaaacc aaactgcaac gaacagaaca 4440 gaactgagca ctttaagcca tttccactcg taattaaatt ttgagagcgg atgaaattgt 4500 ggcggctaaa taaaaggaac aaaatgcatc tgtgcataca gcaaaaaaaa aacagcaaaa 4560 ataaataaca aaatgcagaa gagcaaaaaa tcgcgcatat ccgctttgta aaaatacgag 4620 tctaagtgat gggttccgtt tttgtttagt agtgctcact agtgaacggc cttgtcgcat 4680 ttggggctga tagtggatgt agtgtggggt gtattgtggt gtgcatgggg gtgtttgaat 4740

51 cgcagaagtc ggcccagccc gttggccgtc aagaggacct ggcctaatcg aatgaatgta 4800 gaatgggcac aaacaagtca cgcctgcctg cgcatttcat caaagaacgg cgaacaagag 4860 gctaacagct cttcgtttct ctctctcttt ctctgctcag ctgggtcctt tgaagatcct 4920 gaatgacact caattggcct aatcggtttc tgaaaagcat agtatgaatt tcatacggta 4980 cgctaatttc gaatataaca aaaagcaaaa acgcttttga tatctaaatt gtatttgcca 5040 ttgaaaagtt tatacctata tgtataatat ggaacctttc taaatatagt aattgatacg 5100 aaattgcaaa aatgatggat gaacatctca acattcaaca ggttgcccag ttacttaatc 5160 aatccatcgg tgttgaaagt gagcacttta tacaaaaata ctcatgagtg gttctaaagc 5220 ggataagagg atttatcttg agctcaaaaa ctgatgcagt gatgcaatat tcaagatgtg 5280 tgccttagta ttcaacattt ttgccagatt tatcgaaacg taaataaata aaaatataca 5340 tgaaatttaa taacattgcg cagctttttg gtgaaagcag ttttaattta ataaagcaat 5400 cgttgcgttg aaactaatat tattttaaat tatacaggat acaaaaaata atatacatat 5460 acatttaaat tttgaattta aaaaggggtg tgacagattt actgaataat aataacttta 5520 aacatgccac ctaacaaaag cgaaaacaat tgtttaatta catttgtgca acttgtggca 5580 tttagtaaaa gcgaatatct aagcaaataa gtcgtgtaat ttgatatgca atatagcaac 5640 caaacaaaaa tgcgtgttat taaaatcatg attactgcca tacgtataga tgtttcatgt 5700 cctgtccctt gttgatttca tgctgataaa ggacatacac ttttaaatct tgctaacttg 5760 gtacttttaa cgagcattcg aaggtatcct gtgcccattt caaaaaagct gtaagctctt 5820 tggcagccaa aaaagctgac aaatttgtgc cggaaaggaa acaacttcct atttgcatga 5880 tttattgcca atggaataac aggttggctt cagttgcgta tgtccctgct attcgatttt 5940 caacgaaatt tcggttggca ttcagtcgga atgaaagtga aaacaaaaag tgctactact 6000 acccttttgt gaaagccccc ggagaaaaga caactttcaa ttggccaatt agtgctattt 6060 aaatggcaag ttacgccgtt ttcaaagggc caactatttt gtttttgaag ttccgcgagt 6120 tgtaaatgta ataagcaaat ttcgcagttc tccataggac acctttacac tgagttcctt 6180 tccagttgct caagttttgc tccttggcag ctgcacttgt tgttcctgtt tgccagaaag 6240 ttagtttctg gccaagaatt tgtctttggc caagtactgc tcacgctcgg tttctttggg 6300 caaaagttgg tatttgagtt tcgcagtgga aaagcacttg cggcagatct tcaaattctg 6360 ccaaacccgg cgggctcacg tggccgcctt ctagttattt aataagtaat taagttccct 6420 aattaaatac attctcgcag agatttacat aataagtaat ctacgccgaa cgtcttcctc 6480 cattgcggcg ttaattaaat ttgcagaccg attgcatttc ggaaacttga tttggtttgc 6540 gtctggctgc cagtcgttaa caaatcatga ttgctgaaat ggtcaacttt gggcatcgca 6600 cttcgtatac acttgagatt aaaaattctt taataagggg aaataacact tatttataga 6660 agtattttta aaatatatac aattaatcta gtcagcgctt ttgacgtaat ttatattgag 6720 ttcgaacaac tcatttgaca acatcaaaga atccaatatt cagcaatttt aaacatactc 6780 acatgcgaag ggggaatcga atttccaata atttaaaaag gaatcggaat tttacatttt 6840 ctcgcgcttt tgcggagaag ccgtgatatg gtgactgtat ttatgaaatt tgcttttacg 6900 ccacttccat gaactgaaaa ttggttttca ctgcctgttt ttggtcgata taataatgct 6960 gagatatata tatgatatgt aatgtctttc tatatattgt agcatttacg aagggttata 7020 gcttgatata aaaaaagaaa gaaactttga acaaactcaa gtatataaaa aggtttcaat 7080 aaaatatata aagtccatta gctgtagctt acaggagcat aagttttctt gtttaagacg 7140 aagctttatc gaactttatc ttatagatac atatatctat tactaggata agtaagtaat 7200 tacaattatt tatgcacgct gcattgacat atgccaaaca cttaaagtat tcccacccag 7260 ccgcacttgc tacatttatc agcaattgaa ttaatttcag gttgcggttc agctgagttt 7320 ggtttgtaaa atacattata atgtttaata atcagcagag agcaggaaaa atatgtatta 7380 agttcggcat tgtgttaaac tttaagcgaa tagttaacac agtgttattg gttacccgct 7440 gcttttaata actttccctt tcgatgccca cacaacctga gttattttcc ttaatggtct 7500 gaaaaaatga agaaaaaaaa gtttggctca agtttattgg tttcgcgctg ctttcatcaa 7560 ttgctgcacg caaatgcttc tcaaaaaaaa aaaaaaaaaa actaactctt catttatggc 7620 atttcttagt tgcgaataaa ttccgattta agctggttga aaaaaaccca tcctttcaac 7680 ggtgactaaa catattttaa gcagaccgct caaactcaaa ccgtgggtgg ttaattaaat 7740 aagagcatcg attaagtcaa ctgtcttttt atctgtccca cttttagggt cacccggtgg 7800 acagctaatt gcagctaacc ccattggcat ttagcaaacg gaaaatgcat cgtgaccgct 7860 gcaaccacat tgcaccacta ccaccagcag catcagcgcc accacttcca cctccagcag 7920 cagcaaggga atccgcaccg ctgaaactga atctgaaggc atcccagtgg cggcgacaca 7980 cggaatcctt gccaaatgcg gccaaatgcg aggcgctggc aagtaaataa gcgtaatcct 8040 ttgcgggcac gtaccaccac tactacctcc tgttcggagt agctcgtaaa tatttggcca 8100 agtcagtcat ggaggccatc atcatgacga ccctgcccaa cctgacaacg gatgcaggtg 8160 acagcagctt ctggctaacc ggtgccctct cgctctccga gatgttggcc aactcgagcc 8220 acagccattc cactgggagc acaacctcga cggctgggag ttcggccacc gaatcatccg 8280 ctgtgaatgt aggcaaggac cacgacaagc acgtgaatga cagcgtttcc acgggtctga 8340

52 ggtaagtgca tgtgcctagg cttttccatt tccatggcaa cacacacaca gattccatta 8400 agctcatgac tgcgggctca acaagtcatc gcgataagct cagcttcatt ttccaggaga 8460 tgcattcaac taatgtgctt agaattctac tattgtacat aactaacata tagggaatat 8520 aatcagatta cttagaacct cagaacagtc aatacaatcc acttaatata aatgaattaa 8580 aagtatctat cgaaactgaa aagaagagga tcattagctt gggtacaaca tttataagaa 8640 ttttggctta tgaagttgca aaaagaattc ttaaaaaatt caatacaatg tcaaatagtt 8700 ctgaaaccat aaattattaa caattaaata ttaaattatt tatattgatt taattcatac 8760 atttaaacat aagttacact actgcaagga ggaaagtatc agatgacttg agctatactt 8820 tcataaactt agcttagagc aatctaaacc aaattgaaaa ctcattgaaa cccattttaa 8880 ttgaataaat tgaaacattt acttttccca tttccccagc aattacagta attaccccag 8940 ctacattcac tacagggaca agtacgacct gagctacatt gccaaggtga atcccttttg 9000 gctacagttc gagccaccta agtcgagcac cttcctgatt atggccgccc tgtattgcct 9060 gatttcggtg gtgggatgtg tgggcaatgc gttcgtcatc tttatgtttg ccaaccgcaa 9120 atctctgcgg actcctgcca atatcctggt gatgaatctg gccatctgcg actttctgat 9180 gctcatcaaa tgcccgattg ccatttacaa taacatcaaa gagggtccag ctttaggaga 9240 cattggtaag cttaaaactt ggggaaataa cttactaaat atctatataa atgaaattca 9300 ttcggcttgc atttatgtca aaaatcgatc aacaaaagca atctacataa taaataaaat 9360 taaattggcc caaaatgctt ggactgattt cagctgtttc ttgcagaaat tcatttgtgg 9420 gattctcttt tcccgaaagc aattaataga atttaaatga aacaataaaa gttcaatttg 9480 tagcctacac atcttggttc atgaaaaaca tattccaaaa tgtaatggct attaaaattt 9540 caccgagcct tttgtttgcc ttgaaacggg tggttcatta aaaatcctac tgactttccg 9600 tcccacagcc tgtcgcctct atggatttgt gggtggccta agtggcacct gtgccatcgg 9660 taccctcacc gccatcgctt tggatcggta caatgtggtg gtgcatccac tgcaaccgct 9720 gagacgctgc tcccgcctgc gatcctacct gatcatcctg ctgatctggt gctacagctt 9780 cctgttcgct gtgatgccgg ccctggatat cggactatct gtctatgtgc cagagggctt 9840 cctcaccacc tgcagcttcg attatctgaa caaggagatg ccagctcgca ttttcatggc 9900 actgttcttt gtggctgcct actgcattcc actgacctcc attgtgtact cctacttcta 9960 tatactgaag gtggtcttca cagcgagtcg aatacaatcg aacaaggata aggccaagac 10020 ggagcagaag ttggccttca ttgtggcggc tatcattggt ttgtggttcc tggcctggtc 10080 accgtacgcc atcgttgcca tgatgggtgt cttcggcctg gagaggcaca taacgccact 10140 gggatcgatg atacccgcgc tcttctgcaa gacagctgcc tgcgtggatc cctacttgta 10200 tgcggccacc catccgcggt ttcgtgtcga ggtgcgaatg ctcttctacg gacgcggagt 10260 gctgcgaagg gtctccacga ccagatcatc gtacatgacc cgatcacgat cgtcgttcac 10320 ccaccgattg aggacgagca ccaccggtga gggcggaatg ggtgatcacc gcatggaaaa 10380 ctatctgatg aacaacaatc tgatgatggt gcccgaggag acggaggaga acgaggagat 10440 cgttgtggtg gccgagatca acaattcgat tagcagcgtc atggaacaga gtaagttctg 10500 aaggctgacg attatgccag ttaagagaac ggaaattctg tcaatctgtt tcgaaccaac 10560 taacataaac atttttaatc agttttaagt tttacagacg tgttttatat aatttgaaaa 10620 ttagtcaaac ctatgatcac gatgatactg aaaactttgc ttggaatatc tgaaactcgc 10680 ctgtttaatt tccacttttt ccaattgaaa atttcaattt gatttttgcc caggtaattt 10740 ataaaaaaac ctttcctatc tcgaaaagta aactgttcgc tgttaattga aaatgtttgt 10800 gcactgcact gcaaggcata tcaaaatgga agctatcaat aatcgtaaat tgaatggatc 10860 ggactcaagt ttcattgttg aactaatcta atctaatttg tatgtagaaa taatagaccg 10920 aactgaaatc agcaatggca gcaaagtaat ttcgctcggc aatgatatat gccaatggca 10980 ttgttcatct gagtgaatgc gttgtcattg atggacctac aattgaaatg aaaataataa 11040 taataataaa tagaaatgaa gcagggaaat ccgccgagca gtgggaaatt ggcaaaggca 11100 caacgacgac acagtggtga tagtaaacat atttaatgag cttatgtgat gtttagacag 11160 ggggagtagg cgatcagagc agggaatgga ttagttagcc tatatacata tatatataca 11220 caggcatatg tacatatgta taagacatcg gaatagcagg ccaattagag aggcagggcc 11280 gaaattagta caaagaaaga gggtggcgtg ggtaggggcc gaagtggaaa ttcaatagtc 11340 agattataca tcatttcagg gaaagtcact cggacccaag gtcaagccgt ggtattggat 11400 gttaacaagc ggatgtgcag attgtttgca ttgtagttta atattggaat aactcacaat 11460 caaagcagcc tgcggacatc ttgtatttct gaaatggagt c 11501

<210> 35 <211> 2177 <212> DNA <213> Drosophila

53 <400> 35 ctgggatgca acggatgcgg atgccttaaa tccccgagcc gtttggcggt gttattgaaa 60 attgcgtatt cgccgcgtat taccaagtaa tagcttgtcc aaagccacta cgctgtcaaa 120 ggacgggctt aaaacgctac ttgcattttt acgtactata catagataaa ttttccgggt 180 aatcggcgga aattgagtta aagttttgtg tccggttggc gccagttggc aattggtgct 240 ggccaacttt cggacccgaa cgatgacaaa ctgaaaagta aactttgtaa agactcagca 300 ccttacaaac aaattcaagt gtttcgcgaa aaaaaataaa aaattttgaa ttgaagagga 360 cacagttcgg tgaaaaaaaa atatttgcaa tgcacaatgg aaaatcagca aagtgacctc 420 caagtttacg aaaacagaaa ctaactcaat aaccatccct gcagggtcac ccggtggaca 480 gctaattgca gctaacccca ttggcattta gcaaacggaa aatgcatcgt gaccgctgca 540 accacattgc accactacca ccagcagcat cagcgccacc acttccacct ccagcagcag 600 caagggaatc cgcaccgctg aaactgaatc tgaaggcatc ccagtggcgg cgacacacgg 660 aatccttgcc aaatgcggcc aaatgcgagg cgctggcaac tcgtaaatat ttggccaagt 720 cagtcatgga ggccatcatc atgacgaccc tgcccaacct gacaacggat gcaggtgaca 780 gcagcttctg gctaaccggt gccctctcgc tctccgagat gttggccaac tcgagccaca 840 gccattccac tgggagcaca acctcgacgg ctgggagttc ggccaccgaa tcatccgctg 900 tgaatgtagg caaggaccac gacaagcacg tgaatgacag cgtttccacg ggtctgagca 960 attacagtaa ttaccccagc tacattcact acagggacaa gtacgacctg agctacattg 1020 ccaaggtgaa tcccttttgg ctacagttcg agccacctaa gtcgagcacc ttcctgatta 1080 tggccgccct gtattgcctg atttcggtgg tgggatgtgt gggcaatgcg ttcgtcatct 1140 ttatgtttgc caaccgcaaa tctctgcgga ctcctgccaa tatcctggtg atgaatctgg 1200 ccatctgcga ctttctgatg ctcatcaaat gcccgattgc catttacaat aacatcaaag 1260 agggtccagc tttaggagac attgcctgtc gcctctatgg atttgtgggt ggcctaagtg 1320 gcacctgtgc catcggtacc ctcaccgcca tcgctttgga tcggtacaat gtggtggtgc 1380 atccactgca accgctgaga cgctgctccc gcctgcgatc ctacctgatc atcctgctga 1440 tctggtgcta cagcttcctg ttcgctgtga tgccggccct ggatatcgga ctatctgtct 1500 atgtgccaga gggcttcctc accacctgca gcttcgatta tctgaacaag gagatgccag 1560 ctcgcatttt catggcactg ttctttgtgg ctgcctactg cattccactg acctccattg 1620 tgtactccta cttctatata ctgaaggtgg tcttcacagc gagtcgaata caatcgaaca 1680 aggataaggc caagacggag cagaagttgg ccttcattgt ggcggctatc attggtttgt 1740 ggttcctggc ctggtcaccg tacgccatcg ttgccatgat gggtgtcttc ggcctggaga 1800 ggcacataac gccactggga tcgatgatac ccgcgctctt ctgcaagaca gctgcctgcg 1860 tggatcccta cttgtatgcg gccacccatc cgcggtttcg tgtcgaggtg cgaatgctct 1920 tctacggacg cggagtgctg cgaagggtct ccacgaccag atcatcgtac atgacccgat 1980 cacgatcgtc gttcacccac cgattgagga cgagcaccac cggtgagggc ggaatgggtg 2040 atcaccgcat ggaaaactat ctgatgaaca acaatctgat gatggtgccc gaggagacgg 2100 aggagaacga ggagatcgtt gtggtggccg agatcaacaa ttcgattagc agcgtcatgg 2160 aacagagtaa gttctga 2177

<210> 36 <211> 551 <212> PRT <213> Drosophila

<400> 36

Met His Arg Asp Arg Cys Asn His He Ala Pro Leu Pro Pro Ala Ala

1 5 10 15

Ser Ala Pro Pro Leu Pro Pro Pro Ala Ala Ala Arg Glu Ser Ala Pro

20 25 30

Leu Lys Leu Asn Leu Lys Ala Ser Gin Trp Arg Arg His Thr Glu Ser

35 40 45

Leu Pro Asn Ala Ala Lys Cys Glu Ala Leu Ala Thr Arg Lys Tyr Leu

50 55 60

Ala Lys Ser Val Met Glu Ala He He Met Thr Thr Leu Pro Asn Leu 65 70 75 80

Thr Thr Asp Ala Gly Asp Ser Ser Phe Trp Leu Thr Gly Ala Leu Ser

85 90 95

Leu Ser Glu Met Leu Ala Asn Ser Ser His Ser His Ser Thr Gly Ser 100 105 110

54 Thr Thr Ser Thr Ala Gly Ser Ser Ala Thr Glu Ser Ser Ala Val Asn

115 120 125

Val Gly Lys Asp His Asp Lys His Val Asn Asp Ser Val Ser Thr Gly

130 135 140

Leu Ser Asn Tyr Ser Asn Tyr Pro Ser Tyr He His Tyr Arg Asp Lys 145 150 155 160

Tyr Asp Leu Ser Tyr He Ala Lys Val Asn Pro Phe Trp Leu Gin Phe

165 170 175

Glu Pro Pro Lys Ser Ser Thr Phe Leu He Met Ala Ala Leu Tyr Cys

180 185 190

Leu He Ser Val Val Gly Cys Val Gly Asn Ala Phe Val He Phe Met

195 200 205

Phe Ala Asn Arg Lys Ser Leu Arg Thr Pro Ala Asn He Leu Val Met

210 215 220

Asn Leu Ala He Cys Asp Phe Leu Met Leu He Lys Cys Pro He Ala 225 230 235 240

He Tyr Asn Asn He Lys Glu Gly Pro Ala Leu Gly Asp He Ala Cys

245 250 255

Arg Leu Tyr Gly Phe Val Gly Gly Leu Ser Gly Thr Cys Ala He Gly

260 265 270

Thr Leu Thr Ala He Ala Leu Asp Arg Tyr Asn Val Val Val His Pro

275 280 285

Leu Gin Pro Leu Arg Arg Cys Ser Arg Leu Arg Ser Tyr Leu He He

290 295 300

Leu Leu He Trp Cys Tyr Ser Phe Leu Phe Ala Val Met Pro Ala Leu 305 310 315 320

Asp He Gly Leu Ser Val Tyr Val Pro Glu Gly Phe Leu Thr Thr Cys

325 330 335

Ser Phe Asp Tyr Leu Asn Lys Glu Met Pro Ala Arg He Phe Met Ala

340 345 350

Leu Phe Phe Val Ala Ala Tyr Cys He Pro Leu Thr Ser He Val Tyr

355 360 365

Ser Tyr Phe Tyr He Leu Lys Val Val Phe Thr Ala Ser Arg He Gin

370 375 380

Ser Asn Lys Asp Lys Ala Lys Thr Glu Gin Lys Leu Ala Phe He Val 385 390 395 400

Ala Ala He He Gly Leu Trp Phe Leu Ala Trp Ser Pro Tyr Ala He

405 410 415

Val Ala Met Met Gly Val Phe Gly Leu Glu Arg His He Thr Pro Leu

420 425 430

Gly Ser Met He Pro Ala Leu Phe Cys Lys Thr Ala Ala Cys Val Asp

435 440 445

Pro Tyr Leu Tyr Ala Ala Thr His Pro Arg Phe Arg Val Glu Val Arg

450 455 460

Met Leu Phe Tyr Gly Arg Gly Val Leu Arg Arg Val Ser Thr Thr Arg 465 470 475 480

Ser Ser Tyr Met Thr Arg Ser Arg Ser Ser Phe Thr His Arg Leu Arg

485 490 495

Thr Ser Thr Thr Gly Glu Gly Gly Met Gly Asp His Arg Met Glu Asn

500 505 510

Tyr Leu Met Asn Asn Asn Leu Met Met Val Pro Glu Glu Thr Glu Glu

515 520 525

Asn Glu Glu He Val Val Val Ala Glu He Asn Asn Ser He Ser Ser

530 535 540

Val Met Glu Gin Ser Lys Phe 545 550

<210> 37 <211> 6472

55 <212> DNA

<213> Drosophila

<400> 37 tatgcgcaac tcgacaaaca tcttcctaac caacctgagc attgcggacc tgctggtgct 6_0_ gctcgtctgc acgcccaccg tcctcgtgga ggtcaacact cgcccggaga cctgggtact 120 tggccacgag atgtgtgagt ggcttcagct ccagtgctcc tggtctattt gttctcccca 180 acctaattaa ctgctgttct atcccaggca aggctgtgcc gttcgtggag ctcacggtgg 240 cccacgccag tgtgctgacc atcttggcca tctcgttcga gcgctattac gcaatctgcg 300 agccattaaa ggccggctac gtctgcacca aggggcgggc catcctcatc tgcgtcctgg 360 cctggggcat tgctgcgctc tttacgaggt aagcgattag gctcgtactt gattttctta 420 aatttatttg taaactagca ttatacttta aatatcttaa ttagtttggt cgcttttcat 480 cgcatgcttt ttggtgtttg tagtcctaca tttcgtatgt acatatggta ttatcctgtt 540 tagatctact tcgtttgtgg cctatatccg tttattcatt tcgcccagtc aagcattaag 600 ttcctcgctc attaattata agtgtcaatc gccgtcattt taatgatttg tgttttgtta 660 ttgggttttg cacatttttc cccgttttgt ttattttcca ttatgacgtg gaatttctgg 720 tcttggtgtt tggccttttg tgcgccatct acgctggcgg cgtgtccatt tgtccattta 780 catgctaaac tgcgactgtc gcctatctat tccatttcca ctcctgtcct accacttctc 840 ctgcttcact cgcttcatcg ttgccattgc catttccatt cccaatccca ttcccattga 900 catccgtcgc ctcaagttgc ggacggcttt tgtccaagtt ccggaagctt gccgttatca 960 gcgccctgtc atctttaata agcaccgatg tccgctatca tggatttcat ttcattgaca 1020 ctttattatg gtgcgctccg tccaaggacg agcggcgacc ctttttaatt ttgcaaatct 1080 tgccgcgtcc ataacaatga aataaacagc acattgtcga gctggccacc gacccctcag 1140 cactccggga gtcatggggt catctatggt tggcagctgg gtccgcagga cacccgccta 1200 cgggccgaga cccattaatt acgccacaca agaagcccga ggccaaaaaa aaaaaaaaaa 1260 aaacgggcaa acatttttaa acacattcaa acagacgcgc cacacgacgc ccatgggcgc 1320 aaaaggaggc gtgtcaaata gctgacgcac gtaccaaaac gcccggatca tctttagtgg 1380 gaaaaaaaac acggccatcg cctgttgact gtcatggcat ttcgttttcg aggtctagcc 1440 agggaggatt tgggctgggg ctgtgtttaa tcagcggctc ggataactca aaataatcaa 1500 atatttaaac ttgtctgttt gctggatata tttacaaagt caacagagta tatcccacca 1560 taagttcgcc atctactcac ttatcccctt gtaagtgaaa tgtaatcaca tcaatgaaat 1620 ttggaatatt ttgagcttta gttaaatgta ttttaagatg tatcgatata actcatacag 1680 atactttttt aaaatgagtg gtttcatttt tattaaattt ctgttattat aataatttta 1740 aatgcaatgt tgatattata tttcaaattg gcttaacgcc tacagattag aatacactaa 1800 agatacacgg tatacatttt ttttctagac agaaatatac tttaattcaa ctaaattaat 1860 atatatatgt acctctccca tcttttagct attaaatagt cgaggaactc gactatagta 1920 ttatatccgg ttttggttta aaaaccaatc attgtttttt tttaacgaca cagtactatt 1980 taatatgggc ttcaacatat attttaaatg atgaacccaa gaaatgaaaa aaccataaaa 2040 acaagcggtc atgaaaatcg cgtcctggcc agactggtac attggaaact tgaacttcat 2100 cccagactgg gttaaccttt tgcccatcgc cattctctca tcatcacaaa cagcttctct 2160 tcctgcctgc tgaaacctct tctttttccc gccactcttg gccttttcct ccaaaatcca 2220 accgtatcca ttatccatta tccacgcccc cggtaacccc gccacctgat tacgtttctt 2280 gtttgctttc tctccccaat ctgcaatatc ccccgagcag ccccattctg tgggtggccg 2340 agtacaagct ggccgagtac attgatggat cgtcggtggc cgtgtgcctg acccaggcca 2400 tcagcgactg gacgctggcc ttcttcctga tgaccatctc ggtgttcttc gtggtgccgt 2460 tcgtgaccct ggtggtgctg tacggcatca tcgcccggaa tctggtctcc aacagggcgg 2520 ccatgctgcg cgcccgtccc acgaagccgg agcttagtct gaaggcccgc aagcaggtgg 2580 tcctaatgct cggcgccgtt gtgctgtcct tcttcgtctg cctgctgccc ttccgcgtcc 2640 tcaccctgtg gatcatcctc agcacggacc aaacactgca cgatctggga ttggtgcgct 2700 actacagctt gctgtacttc tgtaggatca tgttgtacct caactcggcc atgaatccga 2760 ttctttacaa cctgatgtcg accaagtttc gaaggggttt caagcggctt tgtcaggacg 2820 cagggcgatt actgctggaa ttggtgacat tgggaagaag gaaggaagac tcttctcgcg 2880 ggcgcagagg taccttgtca ctgggcatgg gcaccaatac gaacacgaat accaactcct 2940 caaatgccac aggagccacg agctccagca ttctctcgag aagctccaat cgcaggtgca 3000 gcgaggatat cagtcgcacc cgccttaaga tcgagatgca gatgccatgt ggcagcgacc 3060 tggaggccat ggccatgctg cagcattcca ccttgggcaa gggaattgcc aggcgagtga 3120 gtgatagccg tctcatgcct ctgagaaatc atcaaccacg acgccacaag ccgcaaataa 3180 gtttcgacga ggagtcactg gaggagaata agcgtagtga agcgaaaatc ccaacaaaat 3240 gtcgagaaaa gcttcctgga atagcaagag aaatagtaaa tctgaccgaa aataccctct 3300 aagcgagatg ggcgtgaaaa atcgccttta acccgtttac acactcgctt cacttggctg 3360

56 gaatgtgccg atgacgctga tcccgatccc gattcctatt cccgctcctg gtaaacacaa 3420 atcgcttcct gaacgctttt ggcagccata atcgatttca gtcacccgct gacagctgcc 3480 gagaatcccg aatcgtagtt gggctgccgc cttggacatt tccgtaccaa aaacaatcaa 3540 tttttcgggc tattaaactc gaatgaatgt gccaaagata aataacagca acgacagccg 3600 aacagcacta aaactaccac tactggtcag ggttaggagt ccagatatcg actggcagta 3660 aggggtaagc cattaggtgg ccttcgagga gcggagctgg caaatggaaa tggcttaata 3720 tgcgtttggg cgaaccatca ggtcggcgga taaacatgat ttaggtgtat tgaaatagtt 3780 tccgtacgcc ggaccgtaca aaatggccgc cattacacgg gcggccatca ccggaagtcg 3840 aaaaaactgt tgcctacttg ccggcagctc aaataaaaag cttagctcaa tatgcacaca 3900 atgtccacat gtaaacacag ctgtacatac acatacatac ccccacacgc acacatagcc 3960 aaatattaat atttatattt gtacgaacat atttatatac acatatttac atatatatag 4020 tctgcttata aatatgtaca aggaaccaca cgcacacact cacacacaca cgagagtttg 4080 taagtaaata aattttttat gacaactcat ggcgggactt ttccacatta ccccatccaa 4140 tcggaatctg taatttatat aattctaagg aaatcggaca aatgttcgtc ctctgtaaat 4200 atacgtattc gtaccatgcg cgtagctttt taatttgttt tcgtagccct atgacgtaga 4260 ctcccacttt tgtagagtaa aaagtaataa gtagcttgaa cccacaccat cctgcgagta 4320 tgatgagtat gagcagacgc tgccgtttcc gtttccgctg tgtgattaag ttgagtgctt 4380 cgcccccgaa acttttccag tagttagccg ttgagtagct tttaaatatt tgtttgtttc 4440 ctgcccgcag cgcgataaaa ctttgcagac agcgctagtc actctagtcc ccgctaaaac 4500 tgataatatg attcttgcag tcccatcatc gccatatcca cctacagcgt ggaaccctac 4560 ggggacggaa ccgatgctcc cgtttgcacc accgccgccg atggtttctg gtcgatcttc 4620 tacttcgtgg gctgcatcac ggtgtttttc ttcctgccct tcggcatcct ggttcttcta 4680 tacgcggcca tcgcttacaa gctgctccgt cccaacaacg ccttccaccg accaacctcc 4740 ccgcagccac agcagccgtc cggcggagcc accagtggct cctcacaggt gcccagcacc 4800 aagggtaaca gccatcaaca aagcaacggg atgaggaagc atcgcaagca ggtaatcttc 4860 atgctggtgg ccgtggtgtc tagctttttt gtttgccttc tacccttccg ggccttcacc 4920 ctctgggtga tcctggccag cgccgaggat gtcgagggtc tgggcattgc cggctactac 4980 aacctgctgt acttctcgcg cttcatgctc tacctaaact cagccatgaa cccgatcctc 5040 tacaacctga tgtcctccaa atttcgcagc ggcttctggc ggctgctgct cacttgtctg 5100 ggccaacggc cacatcacca ccatcgccac cactaccatc agaggcagca tccaacggca 5160 ggcggaagtg ggcgcaatgc gtccacgcga caggaacagg atgccgagga aggagctgcg 5220 ctggcgggaa cgaccagcgc ccgacatcca cgtcgcacac tccgccgcga ggccaccttc 5280 ttgatcaact ccatatccac ctcctcgggt acggatcgca ccacatcatc atcggcgtgg 5340 cgcagcaaca gtctgtccat ttccggtctg agcgaacggg agcgcggcat actgggagcc 5400 gctatcatcg gcacaacggc tgccaccgtt acaaccgcct gtctgcagga gcgacgcgcc 5460 agcaagatct gaatcccatc ctaaatatgc atccttcgag tccctgtcca ctgccagcaa 5520 ccgttaaagt atttagttga attccaacag caaatagtca tagttttaga aaaattttgt 5580 tgtaaagact gaagtacctc agaagaagtc aataaacgca agagaagatg tttttgaaaa 5640 tcgaaactaa ttttcttcgg gcttcgaaaa attgaagttt gcaagattcg aaatagcttt 5700 aacttgattt ttagaacaga aacgagtatg aacttttcat acgatcattt ttatcgcacc 5760 tattgtgatt taatgggaga taggaggaga ccaattggga tatgcaaaaa taacgcaact 5820 attattatct ttgtatgtac gattaatttt aatctctaaa gagtcaaagt acttcaataa 5880 ttttacaaat ctgtcggagg gaatgtaagc ttgcccaaat caaatggaag ctacaatcgt 5940 tgtcagatgg agatatttta tgttagaagg aatatctcgg atacgaaata tttaatttaa 6000 aattcctttt catattattc tttttaaaaa ataataagtc ctgtatgtat acaatgcaat 6060 acataaaggt agagtatgtc ctaaaaagaa aaatatcttt ccgaatatat gtatataatt 6120 tataaaataa gtggatacat acatttttcg taagtatcct agaagatttg ccaacgtatc 6180 aggtttacaa aaattgatta cctatgtgca gttaacttaa cggcagtgca ctaactaatc 6240 tgatttgtga aataatgcag atataaaaca tttttaaata gaaatatatt tatacatctg 6300 attcttcaac atctaagcac tcgtatagag tgctttgaat atattctaaa tacattggca 6360 tgatccaagt tttaaatcag ccaaaaactt gctccaaaaa caggaagatt ctacacaaat 6420 cgcctcgccc ttaaagtttc tgccaagtat ttgggtgcgt gcggatcagt tc 6472

<210> 38 <211> 2196 <212> DNA <213> Drosophila

57 <400> 38 atgcgcaact cgacaaacat cttcctaacc aacctgagca ttgcggacct gctggtgctg 60 ctcgtctgca cgcccaccgt cctcgtggag gtcaacactc gcccggagac ctgggtactt 120 ggccacgaga tgtgcaaggc tgtgccgttc gtggagctca cggtggccca cgccagtgtg 180 ctgaccatct tggccatctc gttcgagcgc tattacgcaa tctgcgagcc attaaaggcc 240 ggctacgtct gcaccaaggg gcgggccatc ctcatctgcg tcctggcctg gggcattgct 300 gcgctcttta cgagccccat tctgtgggtg gccgagtaca agctggccga gtacattgat 360 ggatcgtcgg tggccgtgtg cctgacccag gccatcagcg actggacgct ggccttcttc 420 ctgatgacca tctcggtgtt cttcgtggtg ccgttcgtga ccctggtggt gctgtacggc 480 atcatcgccc ggaatctggt ctccaacagg gcggccatgc tgcgcgcccg tcccacgaag 540 ccggagctta gtctgaaggc ccgcaagcag gtggtcctaa tgctcggcgc cgttgtgctg 600 tccttcttcg tctgcctgct gcccttccgc gtcctcaccc tgtggatcat cctcagcacg 660 gaccaaacac tgcacgatct gggattggtg cgctactaca gcttgctgta cttctgtagg 720 atcatgttgt acctcaactc ggccatgaat ccgattcttt acaacctgat gtcgaccaag 780 tttcgaaggg gtttcaagcg gctttgtcag gacgcagggc gattactgct ggaattggtg 840 acattgggaa gaaggaagga agactcttct cgcgggcgca gaggtacctt gtcactgggc 900 atgggcacca atacgaacac gaataccaac tcctcaaatg ccacaggagc cacgagctcc 960 agcattctct cgagaagctc caatcgcagg tgcagcgagg atatcagtcg cacccgcctt 1020 aagatcgaga tgcagatgcc atgtggcagc gacctggagg ccatggccat gctgcagcat 1080 tccaccttgg gcaagggaat tgccaggcga gtgagtgata gccgtctcat gcctctgaga 1140 aatcatcaac cacgacgcca caagccgcaa ataagtttcg acgaggagtc actggaggag 1200 aataagcgta ggttaggagt ccagatatcg actggcagta agggtcccat catcgccata 1260 tccacctaca gcgtggaacc ctacggggac ggaaccgatg ctcccgtttg caccaccgcc 1320 gccgatggtt tctggtcgat cttctacttc gtgggctgca tcacggtgtt tttcttcctg 1380 cccttcggca tcctggttct tctatacgcg gccatcgctt acaagctgct ccgtcccaac 1440 aacgccttcc accgaccaac ctccccgcag ccacagcagc cgtccggcgg agccaccagt 1500 ggctcctcac aggtgcccag caccaagggt aacagccatc aacaaagcaa cgggatgagg 1560 aagcatcgca agcaggtaat cttcatgctg gtggccgtgg tgtctagctt ttttgtttgc 1620 cttctaccct tccgggcctt caccctctgg gtgatcctgg ccagcgccga ggatgtcgag 1680 ggtctgggca ttgccggcta ctacaacctg ctgtacttct cgcgcttcat gctctaccta 1740 aactcagcca tgaacccgat cctctacaac ctgatgtcct ccaaatttcg cagcggcttc 1800 tggcggctgc tgctcacttg tctgggccaa cggccacatc accaccatcg ccaccactac 1860 catcagaggc agcatccaac ggcaggcgga agtgggcgca atgcgtccac gcgacaggaa 1920 caggatgccg aggaaggagc tgcgctggcg ggaacgacca gcgcccgaca tccacgtcgc 1980 acactccgcc gcgaggccac cttcttgatc aactccatat ccacctcctc gggtacggat 2040 cgcaccacat catcatcggc gtggcgcagc aacagtctgt ccatttccgg tctgagcgaa 2100 cgggagcgcg gcatactggg agccgctatc atcggcacaa cggctgccac cgttacaacc 2160 gcctgtctgc aggagcgacg cgccagcaag atctga 2196

<210> 39 <211> 731 <212> PRT <213> Drosophila

<400> 39

Met Arg Asn Ser Thr Asn He Phe Leu Thr Asn Leu Ser He Ala Asp

1 5 10 15

Leu Leu Val Leu Leu Val Cys Thr Pro Thr Val Leu Val Glu Val Asn 20 25 30

Thr Arg Pro Glu Thr Trp Val Leu Gly His Glu Met Cys Lys Ala Val 35 40 45

Pro Phe Val Glu Leu Thr Val Ala His Ala Ser Val Leu Thr He Leu 50 55 60

Ala He Ser Phe Glu Arg Tyr Tyr Ala He Cys Glu Pro Leu Lys Ala

65 70 75 80

Gly Tyr Val Cys Thr Lys Gly Arg Ala He Leu He Cys Val Leu Ala 85 90 95

Trp Gly He Ala Ala Leu Phe Thr Ser Pro He Leu Trp Val Ala Glu 100 105 110

Tyr Lys Leu Ala Glu Tyr He Asp Gly Ser Ser Val Ala Val Cys Leu

58 115 120 125

Thr Gin Ala He Ser Asp Trp Thr Leu Ala Phe Phe Leu Met Thr He

130 135 140

Ser Val Phe Phe Val Val Pro Phe Val Thr Leu Val Val Leu Tyr Gly 145 150 155 160

He He Ala Arg Asn Leu Val Ser Asn Arg Ala Ala Met Leu Arg Ala

165 170 175

Arg Pro Thr Lys Pro Glu Leu Ser Leu Lys Ala Arg Lys Gin Val Val

180 185 190

Leu Met Leu Gly Ala Val Val Leu Ser Phe Phe Val Cys Leu Leu Pro

195 200 205

Phe Arg Val Leu Thr Leu Trp He He Leu Ser Thr Asp Gin Thr Leu

210 215 220

His Asp Leu Gly Leu Val Arg Tyr Tyr Ser Leu Leu Tyr Phe Cys Arg 225 230 235 240

He Met Leu Tyr Leu Asn Ser Ala Met Asn Pro He Leu Tyr Asn Leu

245 250 255

Met Ser Thr Lys Phe Arg Arg Gly Phe Lys Arg Leu Cys Gin Asp Ala

260 265 270

Gly Arg Leu Leu Leu Glu Leu Val Thr Leu Gly Arg Arg Lys Glu Asp

275 280 285

Ser Ser Arg Gly Arg Arg Gly Thr Leu Ser Leu Gly Met Gly Thr Asn

290 295 300

Thr Asn Thr Asn Thr Asn Ser Ser Asn Ala Thr Gly Ala Thr Ser Ser 305 310 315 320

Ser He Leu Ser Arg Ser Ser Asn Arg Arg Cys Ser Glu Asp He Ser

325 330 335

Arg Thr Arg Leu Lys He Glu Met Gin Met Pro Cys Gly Ser Asp Leu

340 345 350

Glu Ala Met Ala Met Leu Gin His Ser Thr Leu Gly Lys Gly He Ala

355 360 365

Arg Arg Val Ser Asp Ser Arg Leu Met Pro Leu Arg Asn His Gin Pro

370 375 380

Arg Arg His Lys Pro Gin He Ser Phe Asp Glu Glu Ser Leu Glu Glu 385 390 395 400

Asn Lys Arg Arg Leu Gly Val Gin He Ser Thr Gly Ser Lys Gly Pro

405 410 415

He He Ala He Ser Thr Tyr Ser Val Glu Pro Tyr Gly Asp Gly Thr

420 425 430

Asp Ala Pro Val Cys Thr Thr Ala Ala Asp Gly Phe Trp Ser He Phe

435 440 445

Tyr Phe Val Gly Cys He Thr Val Phe Phe Phe Leu Pro Phe Gly He

450 455 460

Leu Val Leu Leu Tyr Ala Ala He Ala Tyr Lys Leu Leu Arg Pro Asn 465 470 475 480

Asn Ala Phe His Arg Pro Thr Ser Pro Gin Pro Gin Gin Pro Ser Gly

485 490 495

Gly Ala Thr Ser Gly Ser Ser Gin Val Pro Ser Thr Lys Gly Asn Ser

500 505 510

His Gin Gin Ser Asn Gly Met Arg Lys His Arg Lys Gin Val He Phe

515 520 525

Met Leu Val Ala Val Val Ser Ser Phe Phe Val Cys Leu Leu Pro Phe

530 535 540

Arg Ala Phe Thr Leu Trp Val He Leu Ala Ser Ala Glu Asp Val Glu 545 550 555 560

Gly Leu Gly He Ala Gly Tyr Tyr Asn Leu Leu Tyr Phe Ser Arg Phe

565 570 575

Met Leu Tyr Leu Asn Ser Ala Met Asn Pro He Leu Tyr Asn Leu Met

580 585 590

Ser Ser Lys Phe Arg Ser Gly Phe Trp Arg Leu Leu Leu Thr Cys Leu

59 595 600 605

Gly Gin Arg Pro His His His His Arg His His Tyr His Gin Arg Gin

610 615 620

His Pro Thr Ala Gly Gly Ser Gly Arg Asn Ala Ser Thr Arg Gin Glu 625 630 635 640

Gin Asp Ala Glu Glu Gly Ala Ala Leu Ala Gly Thr Thr Ser Ala Arg

645 650 655

His Pro Arg Arg Thr Leu Arg Arg Glu Ala Thr Phe Leu He Asn Ser

660 665 670

He Ser Thr Ser Ser Gly Thr Asp Arg Thr Thr Ser Ser Ser Ala Trp

675 680 685

Arg Ser Asn Ser Leu Ser He Ser Gly Leu Ser Glu Arg Glu Arg Gly

690 695 700

He Leu Gly Ala Ala He He Gly Thr Thr Ala Ala Thr Val Thr Thr 705 710 715 720

Ala Cys Leu Gin Glu Arg Arg Ala Ser Lys He 725 730

<210> 40 <211> 3821 <212> DNA <213> Drosophila

<400> 40 cagaaagtgt agggaatgta gggaaatgca aagcgagacc ctttggctgc tcactgactg 60 aaatatcacc agactcggct cggttctgcc gctcaagtgg cagtaaataa aagttgtgag 120 gagccttggc ggcatgagta ataatgaccg aaatcagagc accatcacca tcaccaacca 180 tcgctaccac cgcccaacgc gttgctcatt ttattaaaat aacaaaaata ttttgccgct 240 cgcagccttt ttacgatgcc gaaccgactg gcggcccatt tgttatttgg cggtcattgc 300 caccaaatgg tgtcctgtcg ctctttctcg tcctcgtcct cgtccttgtc cgttccactg 360 ggccaactcg tgtgtcgtgt gtgttttgac cagagttatg cagctgcgga tgggcaaaaa 420 tgttttattg ccagctgggg aatgccaaag tggcaagagg cagattgccc gatcttagct 480 gtttaaataa atttaagaga gagagagaga gagagagatc tggcacgaag cactccatca 540 ctggtccagc gatccgttaa gccatcgagg gtccttcgaa tgaaatgcca gcgctgacaa 600 ggcaaacact ggagatttgt ataataaggg gtgggtggtt gtgccgaaat ttggcactga 660 taggcaggac acttgtcagg cttggcgcaa acaaaactga catttatatt gatgtgtccc 720 tgtacccaat tagatgccca tcattatgag agcaggctat ctctgctctc gtgtccttcc 780 cccttctatt ttgcgcccgg gaagtcatat atcgaacatt aggctctgtt tgtgtgcaga 840 gcaatttggc gggaagtggc agcaggagga cgcacatgat attagtaata atgtaattat 900 atggtcataa acaaaataat aaatcaataa acaacacaca cgcacacgca ggcggcacac 960 gagtaaaagt tatcacgggg gggaaaaaaa tgaaggaaaa atgggaggca gagcagagga 1020 agtgaagaaa agggaaccgg aaaggaaagc cattcatttg gccccgcgac tcaagtgccg 1080 ttgtctacgt ttgcgaatgt gtgtggttgt gtgcgtggca ggacttcctg ttgccacatg 1140 gacggaaacg gcgccataat tatgccataa acccaaccat aaaggacatt tttatagatg 1200 tgcccgagtt aatccctttg ttgttccact cgctaccgca cccatctctc atgtcctttt 1260 tatccgcaca tcctttcagc ttactccacc gccgccctgc tggccatcgt gttcgccatt 1320 cccttcggta tccgcatgct ggtccacaag gatcgaggac agtgggagga gttcggccca 1380 gccttctaca ccgcccacct ggagctttat ctgggcaacg gctgtttggg tgagtctagg 1440 attttggatt tgcaacagga ggagctttca agggtcgaag ctcttctaaa aggttcaaaa 1500 gttggactca gctttaagtt cactcggata tactaaaaat atatataaaa caacacgtta 1560 tgaaactgtt tatgtaccat aaatggagcg taatgtgctt gatttaaagg aacagatgtc 1620 aacagtgctt aaattgtaat aaaaagctat ttgttttagg agctagccag acattattag 1680 tatggactga taagcatatg ttagaagata atatttcata catttagata cgcctataat 1740 ttcataataa taaatcataa aatttattcc gttgggatca tttaatcctt gaacagatat 1800 ctgttatttg ataatattta caaggaatat tatcccattt gcactcctag gcgttggcgt 1860 aatgatgtta ctagtgctga ccattgaacg ttacgtgtcc gtttgccatc caggatttgc 1920 tcgaccagtg atgggaccac ctgggtaagt cgcattgaaa gtctgtagat ggtctattta 1980 attgatccaa cctagcgttg tggtattcct cacctgcttg gccacggtaa tcgtctatct 2040 accgagcatc tttcgtggcg aactgatcaa atgcatcctt ggatcgagtg acgtatatgt 2100

60 atatttgcga cgcgacaaca ctatctacca gcagaccatc ttctatcgcg tctacaagat 2160 catgctggag gtgatcttta aactggtgcc cactttggtg atcggtggcc tcaacatgcg 2220 catcatgatg gtctacaggc ggacctgcga gcgccgccgc aagatggtgc tcagtcgtcc 2280 gcatgcccag ggacatggtc acggacatgg gcacggacat ggtcatggac atggacatgc 2340 acatggacac ggctatttga aggacgacga tccgcgaaag ttcgccgagg agcggcgctt 2400 gttcctgctg ctcggcagca catcgatttt gttcctggtc tgcgtctcgc cgatggccat 2460 tctccacatg acgatcgcct cggaggtcta tccgagcttc cccttccagg tgttccgtgc 2520 cagcgccaat ctgctggagt tgattaacta ctcgctgacc ttctacatct actgcctgtt 2580 cagcgaggat ttccgcaaca ccctggtgag gacgatcaag tggccctggt tgaagggcaa 2640 gttctgccac caggccgagc acgaggtgag tgccagtcca ccggccacag ccggaaccgt 2700 agcggtagcc ggaaccggaa atggccacgt ttctattttt catccggcaa taccggcgct 2760 gactctcaca cccgcagaac ccgacgaacg gccccggtgt gccaatggcg tgcttcacta 2820 aggtggacag gggccatcaa aagcaccaca taactaccac ctcgggcctg ggacgatcga 2880 gtagcattta gacaatgcct accacccaac aacaacacca ccacaaccca tccgctactc 2940 gagatccgaa ctccgaacac cgagaaccct cccagcccag agtaacccca ccaccaccac 3000 ccaactccaa aaccgtcatc accacttcca cttacccccc aggtcgtcga ggttaaaggg 3060 tgccctttct ctcgcttgag atcctgcgac atttgaacgt gttcaagtat cgatgaacga 3120 aaaatgatat acgataaaca actaacgatt aacgataatt gatattcagc gccacgcatt 3180 gcgtatataa gtgtctgtgt gtgttcctta aacatatata tttaaatata tggataaaca 3240 tttttttttt tttagcacta gaattaggta cttaaaaacc aaacttaatc gaaaacacat 3300 ccgtaattgg tgaaataatt gatatcgata ggtaaaacca gttcgacttt cgatcagcat 3360 ttgcgccgaa tgatttcacc acaatgtagc ttgcggaatg tgtatgtcgc aggatcaaga 3420 tcctcaagcc acacgtatag atgcagatat gatagtttta tcaatggata gattgcttgc 3480 cgtattgata accaaagagc tcgtttactc tagcattaga tgcagacaga aaeaggaaca 3540 gcgacaggac aacgacagac agacatattg acatatagac aggtatagac aggtgagatg 3600 gaacaatagc gagagagaga gagaaagagt tttacgatga taatatgcag acatacaata 3660 cttatatata cacttgcata tgcctatatg tgaatgatat ttatgtaaac gacgtattta 3720 tgtatacacg cgtaacttta agcgaatata tttatatatg catatatgta tctattgatt 3780 atagcattta agtgcgcgca agaggaatcc ggattccaac c 3821

<210> 41 <211> 1158 <212> DNA <213> Drosophila

<400> 41 atgggaggca gagcagagga agtgaagaaa agggaaccgg aaaggaaagc cattcatttg 60 gccccgcgac tcaagtgccg ttgtctacct tactccaccg ccgccctgct ggccatcgtg 120 ttcgccattc ccttcggtat ccgcatgctg gtccacaagg atcgaggaca gtgggaggag 180 ttcggcccag ccttctacac cgcccacctg gagctttatc tgggeaacgg ctgtttgggc 240 gttggcgtaa tgatgttact agtgctgacc attgaacgtt acgtgtccgt ttgccatcca 300 ggatttgctc gaccagtgat gggaccacct ggcgttgtgg tattcctcac ctgcttggcc 360 acggtaatcg tctatctacc gagcatcttt cgtggcgaac tgatcaaatg catccttgga 420 tcgagtgacg tatatgtata tttgcgacgc gacaacacta tctaccagca gaccatcttc 480 tatcgcgtct acaagatcat gctggaggtg atctttaaac tggtgcccac tttggtgatc 540 ggtggcctca acatgcgcat catgatggtc tacaggcgga cctgcgagcg ccgccgcaag 600 atggtgctca gtcgtccgca tgcccaggga catggtcacg gacatgggca cggacatggt 660 catggacatg gacatgcaca tggacacggc tatttgaagg acgacgatcc gcgaaagttc 720 gccgaggagc ggcgcttgtt cctgctgctc ggcagcacat cgattttgtt cctggtctgc 780 gtctcgccga tggccattct ccacatgacg atcgcctcgg aggtctatcc gagcttcccc 840 ttccaggtgt tccgtgccag cgccaatctg ctggagttga ttaactactc gctgaccttc 900 tacatctact gcctgttcag cgaggatttc cgcaacaccc tggtgaggac gatcaagtgg 960 ccctggttga agggcaagtt ctgccaccag gccgagcacg aggtgagtgc cagtccaccg 1020 gccacagccg gaaccgtagc ggtagccgga accggaaatg gccacgtttc tatttttcat 1080 ccggcaatac cggcgctgac tctcacaccc gcagaacccg acgaacggcc ccggtgtgcc 1140 aatggcgtgc ttcactaa 1158

<210> 42 <211> 385 <212> PRT

61 <213> Drosophila

< 400 > 42

Met Gly Gly Arg Ala Glu Glu Val Lys Lys Arg Glu Pro Glu Arg Lys

1 5 10 15

Ala He His Leu Ala Pro Arg Leu Lys Cys Arg Cys Leu Pro Tyr Ser

20 25 30

Thr Ala Ala Leu Leu Ala He Val Phe Ala He Pro Phe Gly He Arg

35 40 45

Met Leu Val His Lys Asp Arg Gly Gin Trp Glu Glu Phe Gly Pro Ala

50 55 60

Phe Tyr Thr Ala His Leu Glu Leu Tyr Leu Gly Asn Gly Cys Leu Gly 65 70 75 80

Val Gly Val Met Met Leu Leu Val Leu Thr He Glu Arg Tyr Val Ser

85 90 95

Val Cys His Pro Gly Phe Ala Arg Pro Val Met Gly Pro Pro Gly Val

100 105 110

Val Val Phe Leu Thr Cys Leu Ala Thr Val He Val Tyr Leu Pro Ser

115 120 125

He Phe Arg Gly Glu Leu He Lys Cys He Leu Gly Ser Ser Asp Val

130 135 140

Tyr Val Tyr Leu Arg Arg Asp Asn Thr He Tyr Gin Gin Thr He Phe 145 150 155 160

Tyr Arg Val Tyr Lys He Met Leu Glu Val He Phe Lys Leu Val Pro

165 170 175

Thr Leu Val He Gly Gly Leu Asn Met Arg He Met Met Val Tyr Arg

180 185 190

Arg Thr Cys Glu Arg Arg Arg Lys Met Val Leu Ser Arg Pro His Ala

195 200 205

Gin Gly His Gly His Gly His Gly His Gly His Gly His Gly His Gly

210 215 220

His Ala His Gly His Gly Tyr Leu Lys Asp Asp Asp Pro Arg Lys Phe 225 230 235 240

Ala Glu Glu Arg Arg Leu Phe Leu Leu Leu Gly Ser Thr Ser He Leu

245 250 255

Phe Leu Val Cys Val Ser Pro Met Ala He Leu His Met Thr He Ala

260 265 270

Ser Glu Val Tyr Pro Ser Phe Pro Phe Gin Val Phe Arg Ala Ser Ala

275 280 285

Asn Leu Leu Glu Leu He Asn Tyr Ser Leu Thr Phe Tyr He Tyr Cys

290 295 300

Leu Phe Ser Glu Asp Phe Arg Asn Thr Leu Val Arg Thr He Lys Trp 305 310 315 320

Pro Trp Leu Lys Gly Lys Phe Cys His Gin Ala Glu His Glu Val Ser

325 330 335

Ala Ser Pro Pro Ala Thr Ala Gly Thr Val Ala Val Ala Gly Thr Gly

340 345 350

Asn Gly His Val Ser He Phe His Pro Ala He Pro Ala Leu Thr Leu

355 360 365

Thr Pro Ala Glu Pro Asp Glu Arg Pro Arg Cys Ala Asn Gly Val Leu

370 375 380

His 385

<210> 43 <211> 14111 <212> DNA <213> Drosophila

62 <400> 43 aataatccac cttcgaaggt aaaccatctt aattatgctt taaaattgct ggattatata 60 aacccctaag gtagttcatc ccacttgttc aactgaaatc gacccacaca aatggtggtt 120 ggtatctatc taccagagtt aggagctcgt ttaacccaat attgcctatt cgtagagatc 180 cgcattcctg cgaggagaag tcgaactgcc gtagctgagc tgcgagtcgg tcttcttcag 240 aatggaaacg tggtgggtgg gtgcatcacc cgtccggttg gccatcagcg agtcctgttt 300 gtggagcagg ccgcgtcgct ggtcggcgaa ggagatgacc gagtcctgct tcaccagttg 360 atggcgcctt tgctctggtc gctggtccac aaacgagatc accgagtcct gctttacgaa 420 cttctgccgc ttatcgagca gagagctcgg tgtggcgccc tgtcgccggc ccacatccat 480 ggaaacgcta tccctgtcca ccagtgtgtc gttgagaccg tgtcctgccg acctgcgtgc 540 ctccatgtag gacacaattg agtcctgctt ggacagggag accttggagc cattgctgtc 600 ctgctggcag aggggtcgcc ggatcccaga agcatcactg caggagctct cctgcttgat 660 gaggaactga cgcgatccgt gagagtcctg cttaagcagc atctgctgcg acaggttgct 720 gtcctgcttg agcatcatgt tgtggcgccg cagcgagttg tgctcgtaga tgtaggacac 780 cgcgttgccc ttgctgctcg gactcttcct cgagctgttc tggtggtagt gcgatgactt 840 ccgggtgctg gtggtgctgg aggcgatggc cacgttgtcg tagtacctag gtggttaagg 900 tggaaaaagg gtttttatcg aagggaacac gatttcttac aaatcttcat atcaattttg 960 aaggccttca catattttat caatatattt gaggttagaa attaactaac ctgaggcgtc 1020 cgcagcagct gcgcgacttg atgatggccg cgaatccgcg tcggtacttc ttgttcactg 1080 agtagagtat ggggttgatg cagctgttcg aggagcccag ecactgggcc accggcatca 1140 ecttcttgag gatctcgaac tcctcctgcg agatgtecga gccgaatttg atccgcgcaa 1200 agatgacata gagcggcagc caggacaaaa caaacaggat gaccacggcc accaacatct 1260 tgatgacctt caecttgctc ttetgctgca tgcggtccat ttgcgcgtcc ttggactcgc 1320 cggggatgga cctcgtggag accttgatcc agatgagcac gtagcagagc gtgatcaggg 1380 acatgggcag caggtagcag gccaccaggt tggctagcag gaagtagagg ttcccatccg 1440 tgcccggggg ccacacctcc tggcagagga actgcggctg cgagtaggcc gagaccaggg 1500 cgtcggagaa gacctcctcg gcgggcacca ggtcgaagaa gagcagccaa ggaatggtgg 1560 tcaccagcgc gattacccat atgccgatta tcatgatgcg ggcacgtcgc tttgtcatct 1620 gcttcagggg ccaccagatg gcaatgaacc tgcaagaggg gagtcccaac aaaggggatt 1680 tttaccaagt agtcaaagaa ggagtcttcg taggagcagc agcagcagca ggagctccgg 1740 cttcagatgc cactgacggc tttgagccgt caaggataat ggcaatcatc aagctgtcga 1800 gtcgagtcga ggcgacgatg acgatgacga caccgtttca actaggagga gcagctcggc 1860 atgcaaatat ctccgctgat taattcgcac acgcaggatg ccgatgccag cagccatcct 1920 taagcctttt tctgctgagt gttcgctttc caatctcgac tattgaaccc gcctgctact 1980 cctgctcctg ctcctccgcc ccaaaaaagc ggcgctgcgg atcctgtcat tttttattct 2040 gcttgccata atgaattgta atttgaataa gagctgcgag gtagtgagac gagtcggtat 2100 ggggccaaca acgagttcag catttttcat ttagcttagt gcagccggct cattgtggcg 2160 cccgctcagt ggtcatagac aagacttgtc ccggacgaac gaaactggtt gtctgctcct 2220 ggcccgaaac catgtaatta cgtgcattgt gttcgtattt tcgacttgga ccttgggttg 2280 tcgcctgcgt ctgtccgcca aaacatttgg cagataacac agcggtaatt ccattagagg 2340 gcggccatgc caggccacta ccccagaatc ctattcctca ccgactaaaa atagccagct 2400 taacaatgtg gccgagaccc tcatctctgc gaaaaaaaaa aggtgggccg cctgggcgac 2460 caaacaaagc tgtccgcaaa gccaataatc aaattgtcat aacgtttatt tataggagca 2520 aaccaattgc atttgcataa tttgcccatg cgacttctat ggtcataaat caggcgagag 2580 cttaattgag ttctttttgg gtaaaaacag cggagtcgga aaaagtaatc agcagttttc 2640 gctggtgcag actaattcaa actaaacctc taatttgatg ttgaaatttt gttaaatcgt 2700 attaactaca cttttgatga tgtaaaccat tttatgagct ttaaaaacta aaatttctct 2760 tatgagttct cttatacgat ttatgtatga tttgtttcac aaataaactc tccttataga 2820 ttcaattgct gtcggaaaat taaattatta atattatttt ggtaatcacg ggtaattgtt 2880 gcccatcaat tccgttgagt accatatgcg taaatctcta aggacgtcag ttcagtattg 2940 ttagcatatt tattaagaaa aatcttgcca caatcaactt aaacaaagta gttaatactc 3000 gcgcttttaa agcatttaat aagccgcaag tgtattaatt taatatttgc cacacaatcc 3060 tgtgtttctg tctagatcca cgtggtttta tggctcctat ttcgcttcct actgcggtta 3120 cccatacgca ctgttgacat ttgcgacgca aagaagacac aaaagccgca atgccagcac 3180 cgtaaagaca caactatgtc tataagcgag tgtgctttct tatagacttt atgattataa 3240 gcaatctagt tatatacata tacgtattca gacaagaaaa gaccctaatt aaatgacagt 3300 ggcataagta taaatataag tagaagtaga agtataagca agtgataagc taagtcgaag 3360 gggcattacg ggctctaaga ccgtggagag atttaagttt catgttacag ataataaatc 3420 ttaaatttcg attcagttta cgatggctcg taaaaggaga gaataacagc aaaacaactg 3480 gataaacgga catcaatgac gctggactcg gacttcgact gggacttgga agtggaagtg 3540

63 gaattggaag tggatgagga tgtggatgtg gatttggact cggttgggtt ggcgttaagc 3600 gtgggcggag gctgacatgc gggcctgtgg gtgaccaaac gatcaagtga ggcgctatgc 3660 ctttgtcccg ctggctgaaa aatgacagtg gcaaaaacag aagcttctgg ccaaaactcc 3720 tcctctgatt gtggccagaa attgatataa atgaaagtgc acataaagcg acgggcgtct 3780 tattgtcett gcggctatgg ctagcacaat ttgagggaet tcagcatcac ttgataaatc 3840 tgttgaccgc gacatttgcc gaatttattg cttttttata ctttatgggc caggaaacgc 3900 agggctgaca eatcgattcc tggcggceaa tcatcaatgg tatcaatatt cgcggtatcg 3960 cggccaacaa cattctaagg caattgaaat gcacataaaa tgagaaacat gaaattgatt 4020 gtaagcagcg cctaatacgg acaaggtgag ccatagaagc atatgatgat cttgatcttg 4080 agacgactgc tccactgact ctcctacata actgcctaac tggctaactg ccttactgac 4140 cagttttccc cgcagctgat tgcattgagt ggcgctcact ttcggttcgg tcgcctggtg 4200 caaatccact ataaaagccg cactcggagc tcaagttgtc accagttgac aatttgaaat 4260 cattagccta gctacctttc ctacttcagt tatcccgcca aaatccaacg cctcaaaatg 4320 ttcaaagtag tgagtatcat tgtgcagaag aagttgtaac cagtttgaat ccaagcatcg 4380 tatcattatg atattatate agtttgctct atagcattta aaaataaatg caataaatta 4440 agtttatatt acaactcata tgagtcacct agtttgttgt taggattggt cttatcttac 4500 tcagaatgag taatatatgc tttaaagtct gcgacaacta accaaattca ctgtggagtg 4560 gcagccacct gctgctccgt ctaatgccac taatcaggct aattcgtgaa ctctgatccg 4620 ccgcagctgt tcgtgctcgc cgccttcgtc gcctctcagg ctatcgccca tcccggcgtg 4680 gtggccgtgg cacccgtggt ggcgcacccg gcggtggtcc acacgcccat catccatcat 4740 ggagcccact cggtgcactc gtaaggccat tcatgtccaa tctgcttatc accaccgaac 4800 aactcacccc tttcattttc agccatgttg ttcatcatcc ggcagccgtc aaggtcatca 4860 cacccgtcgt ccacaagccc gtggtggcgg tgcatgctgt caggccggtg gttccattgg 4920 ttccagtgca tcatgccgcc cccgccgtcg tcgtgcatca ttaagtgcag cgaatacggt 4980 tcactttcaa tacctttccc gctcccgatc ccgttcccga tccccaccag acccagacca 5040 atcccttcct gagcaccata accacgatcc cacaataaaa gttcatagcc acgtaattgg 5100 agcgagtgtt ttcaacttac ctgtccaggg aaacggcaat caggctgtag accgaggctg 5160 ccacggagac accttgtatg tagggcacaa acttgcacat cagccatccg agcatccagg 5220 ctgcgagttc cagcagttcg cgaaacatga aagggggaaa agtgcgggag gtgagtaaat 5280 attggtcata aacaacgcac aaattatgct gagtaacttt cggtcacatt gtccttgctg 5340 gtgtcctagc catacactga aggaaatgtg agggcctatg gcaacaaaaa aagaagaaga 5400 tgcagatttt tctaaaatac cccaaggaca ctttgctcga aaactttata aatatcctaa 5460 ccacgaaaat caaagcaaat taatgtggtt aaccgaccga aggatgctta ttgttctcat 5520 gggaaatatt cgaaatagta gatggtgtat cactttaaat acaaaccgta agtcatcttg 5580 actgcttagc taagaaaaga gtgaaaatat tataaaacta ataattctcc gctaagtatt 5640 ataatatatt tcatatctta cttttattct tgaataagta cagttttaca gctggggatc 5700 attgagttct ttatagcttt actgcttttc cccgagtgca ctggtagtgg ttatgctcat 5760 ggttgtggtg atggtggtgg tggtgatagt ggtagtcatg gacagttggg ttcgagatct 5820 ggttagcgtt caatgcttct tgtcattgcc gccgcccacg ttcccgtcgt tgtttgctga 5880 ctgagattta tgtgctgcat atcattcata atttggtgac aagtctcaga ttgcgcccag 5940 ccatcgtagt gggtggggca gaatgtggag tcctgggggg cagagcattg tttgcccaga 6000 cccagactca aagccgcggt ggaccgcagg actgcctaac ttaatttgta ttccttttac 6060 tccattttgt ggctggatga tgatggtaaa tggaatacac gggccctact tgcgcatagt 6120 tgagcgttat gaattttatg ctaagaggca taactcaccc agacacaaaa ggttataaag 6180 catacataca tgggcgtgca atgggagggg caacttccca gggttgatga cagtcgggcg 6240 gagaaaggcg cccggttcat gacatatcga atggcaatta aacaagtgca agtgcggccc 6300 acacatcatt agcagttagc tgtttggcag tttggcaatt tgcagaagga gtttaccgag 6360 ttcaatgctc gaccaggaga cgcctcctgc gtcatggggc tcctaatttc ctgtctcgtt 6420 cgcctgtctt atctctattt gttgtcgctt tttattatgc agacgcaccg taagccgcca 6480 aggcagccca ataaaagcta actttaatat gatttggcac ataaaaatat aaatattatt 6540 ggcgctgtgg cgcttcgtgc aagtgaactc tgtggctgtg gacaggtttt ggttctggac 6600 aggatcatgt gtgtctgctg ggaggacata cacatcctcc cgcctggcaa acaatcaaca 6660 gtgtgtacac aggacagcag accgaattgg tttttcggtt ttattcctcc gatttgaaat 6720 ggctttcggg cagacctgca agtgcaacag actggatccg aggctattaa tgcgagtgta 6780 tttggccact cacttgatat tatgctgata agggtgaact ttgatatata gctgtctgcg 6840 ggagctcttg actcggcaaa ctttatgctt tcaagttgtt tgaaaacaat ttaaattcaa 6900 attcggttcc gaaatgcttc atcacttgcg ggacaccgga ttagcagtgc cactgggtga 6960 actttttttt ttttttaaat acatgttctt ccaacttccc ttcggcaaat aaactatcta 7020 attgtgtatg caattctatt aggacaggca aacgtgactc ggttggtttg tctgggatta 7080 aagtttgcat cagtgcactt tggcagtcaa gtgtcttaac caagtttaca ttgtggttag 7140

64 cttagcgcag tcaagtgacc acttgataat cccgaacaaa caatggtttt cagttcatat 7200 ggaaagtatt ttgacaggct gaggcattca gcacggttca acttattaaa ttgtccaact 7260 cgctgatttg gatatttaat ataaaaatgg aaaaaccaca ttttacagaa ccaacgagaa 7320 aagctgacat ttaaaattgg tttttgttaa cataaaacga ttgagaagga ataatacata 7380 attaatgaac cgcaaaaacc gcattatata taaaaaaaat caaataggtc aagggttatg 7440 ccagtagtta tttatagata ccacaagctt aggtaagaca tgattatttc aaggaacacc 7500 gagtcattcg aaaccaatct ttaattaacc ccaaccttaa ggccacatta atgtgttgta 7560 caaacataat tgtagctacc gaaataacct aattgccttg cgtgacgggg ctaacccgaa 7620 cctccttgtg gcattaccca tttgaggact caagtgaaac caaacactcc acagtttgct 7680 cggccaacat ccagcctccc cgtcaaggtg agaatgggat gggtgtttga tccgacttgg 7740 agtgcgtttg acatggcaac atatggcaaa cagacgcctc catttatacg cgaaagctgg 7800 tgctcaatat tgatcaacta gaggagataa taccaatcga tactcaggct tatcgccagc 7860 cttcgattgt gggtggtggg tggtgggctt gtgcgcccca tcagccctta agaaaatgtc 7920 aagtgcgccc taagcctttt attttttagc ctcttaccct ccttacaacg agagcctttg 7980 tttttcggtt tcggtatata tgacttttag aaatgtgatt caactgaaaa tatttacctt 8040 atttgataat ttgcctgcag aattaaattt aacgcggtta tttatgaata atgtcccctt 8100 atttggaaac aaatttttct caaggacaac tttaaaacgc gttatctttt acagcaacaa 8160 taaacatttt ctctactgtg ctttatgagg ctttaatagc gccaacaaag ttttgttaca 8220 tttttatccc caataccgtg ggtgattgtt cctatgtagg caaagtggat tggattattc 8280 cgggcattgc ggattcgttt cggtggcggc attgtcatgc acggagtttg atcgtaaagt 8340 taatgaaata atcaggcgtg acaaatccgc aggtttggac ttgggagtgg gaacgggcgt 8400 ggattgcagt ggagtggagt ggagtggagt ggccatggaa aaggcataac ataacacttc 8460 tggcaaatgc gttattgtta tgattatcgc cgcggcgtca cgtcctgcgg cgacttctgt 8520 ggcagctctt cgggaaaatt gaataccaca gctagttcgc agagaaatgc gcctgggacg 8580 cggagtggga ataggaattg gaatctggga atcggtggtc ctcgatgtga gatacgggat 8640 tgcgggagta aagaagctgc agatcttagg tggagggctc agaggttgga tgccatttgc 8700 cgacggcacg tagagactaa attaaaatac aattggcgag ctgaaaaatg acttcatcag 8760 ggatagggaa acagaaatgc gggagagtct gcctccaagt tacgcatacg ccgcgttcgc 8820 ccggcacaaa tcacgtggcc ccctaatgaa caaactggca acgtgactga aagatttagc 8880 caacgggaga tgctgatcta aaaagggccg taatgataac gattccccat tgataaaata 8940 gcacaacaat ggccataaag cgccatctga gacaattgcc gttgctgttg caaggatatc 9000 cttcgtctca aggcggcatc gttgctggga aatcaattca tttcgcattt tattggattt 9060 caaagcacac acataaataa gggccagcgc cacattccga ccaacaacca ccacccacca 9120 cccaccaccc acaggccacc agccaggaac cacccacaaa gagtacacgg cccaacccaa 9180 tacaggtgct cccacacccc acgcatacac acacacacac accctcaacc acacacactg 9240 gcacactcgc aagtgtgtgt gtgcataacc ctgactatta ggtttgccaa gcgaaatatt 9300 taggtcaatt catccagccg caaagagcct tgaatgcaaa caaccttcca ttgcaattct 9360 gaggcttgaa ggtgtgctta gataatggcg ctgccagcgg cgatggccgt gggcgtcgct 9420 gccagctgcg actgcggcgg cgacgtcgtc tttgacggct ggaatttgat ttcatataat 9480 tcattttggt ggcaaaacaa cccgcccact ttgccactcg ctgggggcga gtagtgggaa 9540 ctatcagaca gcgatgtgaa atgctcgatg tacaaatatg ctaaacttcc gaactcccac 9600 gcactgtgct acacagggag aaaaggtttt gttagaggag agcaaaggat taagtggtat 9660 gactttacac tgctaatttg attatgaaga atattcgtaa gagttatagc atttcatcac 9720 ctgacgaagt tcaaaaacat ttaagtttaa agccaaaaag tgtatatttc tgaaaacgtg 9780 tggattgttt aatgaaaatg acgtgttaaa cttttgtttg taaataatac gctacacatg 9840 tgtttagttg gcaacacatg ttttttcccc tgcattagtg ctatttcacc gttgccgctg 9900 tgaaaccgtt gccttcgttt taacttcagc aggttgtcga aagtgaatag gaatgtaagt 9960 ggggttgaga gttgtgggga tgaagaggtg aagctgaaat gagccacccc aaaagcccca 10020 atgccagcgg gagggctgca atttgttgtg actggcgttt ttgctaggca tcggcggctc 10080 agctgaagct aagacatgcc aagcgaaaat tgcggagtgg gcggccaaaa gggtgcccca 10140 tccaaacaac catacaacca tctagcccac ccaatctacc atccaccgcc agccacccac 10200 cacccccagt gacccagtaa gagctgtcgg ccctgcgccc agcttgaatt tgtgaaatta 10260 ggteagtttt gtgtcgatga tcctttgggc caccccgaaa agcagccacc aatgcaccta 10320 cacatgcaca gtagcgagca aacacatggg cgtgagagcg ggcgagagag agagagcgga 10380 gagagtgcgc agtgacacgg acacaaaaac ggagaeacgg acaccgatac agatacaeaa 10440 tgcaggcgga ggtaaactca ttcacttttc gccactcgct tcattcgttt ccagcgattc 10500 gcactcggca gccttcgttt actacatttc ccccacagtg ggcttctctg ggggagtgta 10560 ttggtatggg gtgggatcga gtgcagtgcc gagtctaaga gtagagctgc attggaaaat 10620 aaatctgata agtcaactgc atctgcatat ttgttaccag tttgtaatat taatattcag 10680 gttaataaat aatctgaggg gaagaggaac taaaactatt tttattatta ttattattaa 10740

65 tttaatttaa tttaatatta ttattattaa ttattttaaa taattttaat tattttcata 10800 tacttgtggc aaagaaatgt agtaacacaa tttgttaaac tatttcctat taatcgaaea 10860 tattgtttta cgagtatgtt gacaactctt attttgccag cgtactcgct gtatagcaac 10920 aagaaaagga gagttctcac agggctgagc cacttaattg gcaacacttg geacaacctg 10980 egagcctacg acctggcatt gggatttggg actagggacc tggcactggg attggggtag 11040 ccatcgaagg caaattgcag tgaaggatgg agcttgcatg gcgtgctcca caatcggaat 11100 ttgatttacc aaggatttcg atcatttttc catgtcagcg gcgatttgca tagacatttg 11160 ccaacctgct caccttgtcg tccaggtctg cgactatcaa tttggatgtc agtccacaaa 11220 gttcgtttcg aatgcaagcg gggaagttgc ggaggggaaa ccaaccaatt gggggtgtaa 11280 gacggcagac agggacagat agatagatag atagatggac ggatggatag gcatgtcagg 11340 gaaatttatt taaattaaag catacaatta tgcgtagcct cgtttatcgg gtcgtttgtg 11400 ggtcgtctct gggatttggt ggaattggcc tctaattaaa tggacacttg ttctttggtc 11460 catgcggatt gtcgtttcca agaaggtaag ggctcccatg gagagagcac aaattaattt 11520 aattgagtgc gaacatccgt tgctacggaa atctgacaca tttctggtaa agtacgctga 11580 atgaattctt ctttttttct ttgctgcgta ctgtgtgaga tgtagttcct tgatttaatg 11640 aataactggc ttttgtcttg gcagtctatt ttaaaagtta tcttgaccat tgcagaaagc 11700 tattaaattt tgatactaaa gcttggcatt ttccagaaca actttaatga tgctgcatcg 11760 ttatgttctt cttgtgtatg tagtaaaaat tcggaagaag ccagggagtc tggtatataa 11820 aatgcagctt acaaataaac ggaaacacag tatgtctgtc aaaagtaaat ataaccgagt 11880 atgaataaaa tcccataatt tattattttc caccagaaat atgagcactt tcgtttggac 11940 atttatgccg acattatgtc taatgagggt caattacact tgcccaaaca tatcgggcac 12000 attacgcata cgcagcgtaa gcacgcagga gcaacaactt tcgtcagtgc catttggcag 12060 ggctttatct aaagcggcga ttaattgcag tacataaatc gggctaatat gcagaacaaa 12120 caaaaaaaaa cttcggcttc cccctagcag ctaacgtggc ccccagtggc gaataaatct 12180 cgtcggcatc ttgcggaatt aaagagatac ttacgcacaa agatgttgcc aatcagtgtg 12240 gctggcaggc agaagacaat gaccaggatg tccgcaatgg ccttttcgtt ggagaggggg 12300 gaatgtaaat tttatttcaa attaatgggg ttcatccacg agatttacgg ggtccaccca 12360 ccagattcac aatgaagtag ttcgtcaccg tccgcatgcg aggagcccgc aggacgacgg 12420 cgatcacgaa gctattcccg atgagtccca ccaggaagac gacgatgtag gccacgcagt 12480 agaccatgga catggccagc gagtgacggt agagtgggtc gaatccgaag tccacgctcc 12540 cgtccagctg ctcccaccgg agggcactgt cgttgtacga cttggtggcc gcagccgccg 12600 agatcaagct ggtggtcgcc ggcgataggt tcagcaagtt ggaatagtag gtggatgaag 12660 tggcgtctgc gatggccagc gacttgcccg ccagggatcc tctcgcagat gctgttgtgg 12720 tggccgccaa ggtggctagc agcgaactgg ccgccggagc caccgtggcc gtggccgtag 12780 tgagaaccgt gcccagcaga gtgtccgtaa tggcgctgtt attcagttta atggcactcg 12840 atgagcccaa ggagctgaca gcagtcccac cgctaccact agtgccattc aattcgttga 12900 aactcaagag gttctgcaaa tcgacgaaat tatgcgtgaa attattgtaa tccccggcga 12960 gggcggcggc ttcctccatt gtctccgcga ccattttccc cggcgccatg gtcggaatgg 13020 gcatgggtac actagtcgtc gtactgggaa cgtcgccact tgtatggctt ttatgctttc 13080 gcttgcgaat ccgcccgctg gctgccatca tcaaatcatc cggcgtcttg attgggcgga 13140 tggcactttc actggcgcct cgctttcgct atcactatct gtagacgtat ctcgaatctt 13200 gaatctggta tctcgcttgt tttagaaaag gtctataaaa atggcatcgt cacttggcat 13260 ttcgttggct tgtgtaggat atgcaggaag tttcgtggct ttgggttaga gaacagtttt 13320 taattaacac ccatgtccat acaatatctc gtttatccgg ggattgtttt gcgtttgccc 13380 cgaagttgca caataaatgc agttttctag aaactcgctt ctagcgccca aggacccttc 13440 cgttttcgtt tttttttttt ttgattgaaa tcacctacaa aagtttgttg ccgtttcggc 13500 tgcgaatccg agtgcggaat gcaatgcatt gcctgggtcg ttcgtcagct ggttgacgtt 13560 gccttggctg gcattacgaa aaagtcggcg gcccaaggcc tcgtgtgcat atttcagata 13620 aggccagatg ctgggtgcct ggataaatgc agctagaggg gattggggat cgggcattgg 13680 gcattgggca ttgggcattg ggcatcggac atcgggcaaa ggagccgaga gcatcggctc 13740 agggacatgg tcaccgccac agttgcaaca catgcgcgtc gctaattaat tttaatgccc 13800 gttctgccat tgtttggctg ttgtttttgg cacaattgaa aagccagcga gcgtgcactt 13860 tgacctcaaa aaatcgacac caaacatcga acaaacgagc aattgagcaa ctcaatagca 13920 gcgcataaaa attccattaa gcacaactgc caagcgcacg cagcactctt cgattgagtg 13980 ccaaaaaatt gccagtaagc attgaaacaa ttggtaacaa acgaagccag tgcgacattc 14040 ttttgtgcgg ttccatggga gtgtccacat cagacaaact ggcgactaag ggcccctcgg 14100 cacacaattc a 14111

66 <210> 44 <211> 1525 <212> DNA <213> Drosophila

<400> 44 atgatggcag ccagcgggcg gattcgcaag cgaaagcata aaagccatac aagtggcgac 60 gttcccagta cgacgactag tgtacccatg cccattccga ccatggcgcc ggggaaaatg 120 gtcgcggaga caatggagga agccgccgcc ctcgccgggg attacaataa tttcacgcat 180 aatttcgtcg atttgcagaa cctcttgagt ttcaacgaat tgaatggcac tagtggtagc 240 ggtgggactg ctgtcagctc cttgggctca tcgagtgcca ttaaactgaa taacagcgcc 300 attacggaca ctctgctggg cacggttctc actacggcca cggccacggt ggctccggcg 360 gccagttcgc tgctagccac cttggcggcc accacaacag catctgcgag aggatccctg 420 gcgggcaagt cgctggccat cgcagacgcc acttcatcca cctactattc caacttgctg 480 aacctatcgc cggcgaccac cagcttgatc tcggcggctg cggccaccaa gtcgtacaac 540 gacagtgccc tccggtggga gcagctggac gggagcgtgg acttcggatt cgacccactc 600 taccgtcact cgctggccat gtccatggtc tactgcgtgg cctacatcgt cgtcttcctg 660 gtgggactca tcgggaatag cttcgtgatc gccgtcgtcc tgcgggctcc tcgcatgcgg 720 acggtgacga actacttcat tgtgaatctg gccattgcgg acatcctggt cattgtcttc 780 tgcctgccag ccacactgat tggcaacatc tttgtgcgta agtatctctt taattccgca 840 agatgccgac gagatttatt cgccactggg ggccacgttc attgccatct ggtggcccct 900 gaagcagatg acaaagcgac gtgcccgcat catgataatc ggcatatggg taatcgcgct 960 ggtgaccacc attccttggc tgctcttctt cgacctggtg cccgccgagg aggtcttctc 1020 cgacgccctg gtctcggcct actcgcagcc gcagttcctc tgccaggagg tgtggccccc 1080 gggcacggat gggaacctct acttcctgct agccaacctg gtggcctgct acctgctgcc 1140 catgtccctg atcacgctct gctacgtgct catctggatc aaggtctcca cgaggtccat 1200 ccccggcgag tccaaggacg cgcaaatgga ccgcatgcag cagaagagca aggtgaaggt 1260 catcaagatg ttggtggccg tggtcatcct gtttgttttg tcctggctgc cgctctatgt 1320 catctttgcg cggatcaaat tcggctcgga catctcgcag gaggagttcg agatcctcaa 1380 gaaggtgatg ccggtggccc agtggctggg ctcctcgaac agctgcatca accccatact 1440 ctactcagtg aacaagaagt accgacgcgg attcgcggcc atcatcaagt cgcgcagctg 1500 ctgcggacgc ctcaggttag ttaat 1525

<210> 45 <211> 507 <212> PRT <213> Drosophila

<400> 45

Met Met Ala Ala Ser Gly Arg He Arg Lys Arg Lys His Lys Ser His

1 5 10 15

Thr Ser Gly Asp Val Pro Ser Thr Thr Thr Ser Val Pro Met Pro He

20 25 30

Pro Thr Met Ala Pro Gly Lys Met Val Ala Glu Thr Met Glu Glu Ala 35 40 45

Ala Ala Leu Ala Gly Asp Tyr Asn Asn Phe Thr His Asn Phe Val Asp

50 55 60

Leu Gin Asn Leu Leu Ser Phe Asn Glu Leu Asn Gly Thr Ser Gly Ser

65 70 75 80

Gly Gly Thr Ala Val Ser Ser Leu Gly Ser Ser Ser Ala He Lys Leu 85 90 95

Asn Asn Ser Ala He Thr Asp Thr Leu Leu Gly Thr Val Leu Thr Thr 100 105 110

Ala Thr Ala Thr Val Ala Pro Ala Ala Ser Ser Leu Leu Ala Thr Leu 115 120 125

Ala Ala Thr Thr Thr Ala Ser Ala Arg Gly Ser Leu Ala Gly Lys Ser 130 135 140

Leu Ala He Ala Asp Ala Thr Ser Ser Thr Tyr Tyr Ser Asn Leu Leu

145 150 155 160

Asn Leu Ser Pro Ala Thr Thr Ser Leu He Ser Ala Ala Ala Ala Thr

67 165 170 175

Lys Ser Tyr Asn Asp Ser Ala Leu Arg Trp Glu Gin Leu Asp Gly Ser 180 185 190

Val Asp Phe Gly Phe Asp Pro Leu Tyr Arg His Ser Leu Ala Met Ser 195 200 205

Met Val Tyr Cys Val Ala Tyr He Val Val Phe Leu Val Gly Leu He 210 215 220

Gly Asn Ser Phe Val He Ala Val Val Leu Arg Ala Pro Arg Met Arg

225 230 235 240

Thr Val Thr Asn Tyr Phe He Val Asn Leu Ala He Ala Asp He Leu 245 250 255

Val He Val Phe Cys Leu Pro Ala Thr Leu He Gly Asn He Phe Val 260 265 270

Arg Lys Tyr Leu Phe Asn Ser Ala Arg Cys Arg Arg Asp Leu Phe Ala 275 280 285

Thr Gly Gly His Val His Cys His Leu Val Ala Pro Glu Ala Asp Asp 290 295 300

Lys Ala Thr Cys Pro His His Asp Asn Arg His Met Gly Asn Arg Ala

305 310 315 320

Gly Asp His His Ser Leu Ala Ala Leu Leu Arg Pro Gly Ala Arg Arg 325 330 335

Gly Gly Leu Leu Arg Arg Pro Gly Leu Gly Leu Leu Ala Ala Ala Val 340 345 350

Pro Leu Pro Gly Gly Val Ala Pro Gly His Gly Trp Glu Pro Leu Leu 355 360 365

Pro Ala Ser Gin Pro Gly Gly Leu Leu Pro Ala Ala His Val Pro Asp 370 375 380

His Ala Leu Leu Arg Ala His Leu Asp Gin Gly Leu His Glu Val His

385 390 395 400

Pro Arg Arg Val Gin Gly Arg Ala Asn Gly Pro His Ala Ala Glu Glu 405 410 415

Gin Gly Glu Gly His Gin Asp Val Gly Gly Arg Gly His Pro Val Cys

420 425 430

Phe Val Leu Ala Ala Ala Leu Cys His Leu Cys Ala Asp Gin He Arg 435 440 445

Leu Gly His Leu Ala Gly Gly Val Arg Asp Pro Gin Glu Gly Asp Ala 450 455 460

Gly Gly Pro Val Ala Gly Leu Leu Glu Gin Leu His Gin Pro His Thr

465 470 475 480

Leu Leu Ser Glu Gin Glu Val Pro Thr Arg He Arg Gly His His Gin 485 490 495

Val Ala Gin Leu Leu Arg Thr Pro Gin Val Ser 500 505

<210> 46 <211> 3688 <212> DNA <213> Drosophila

<400> 46 tgtttgcaga gcccacagca accaatatgt tttcattgtc tgcccggttt gtcgctcaat 60 ttatttgtga tgttgacttt ccaacagtga cgtcagtgga ggccacagac aataccacat 120 catcgcaaca attataaatg gtgtggtggc gaaaaaacgt ccttgtgccc attgttcagt 180 ggggcgaact gaaaagtgga ttttccagcg cgtgccagga aaatgaatga aaatgcggga 240 cattcttgaa gtcgttgcct ttattctgct ttcacacata attatgaaat aaatattagc 300 ttaaaccaaa ttgactacaa cgttatgctc tattaactct tatggtctac ttatgcttaa 360 tgggttttgg tttaagatgc ttgggcatgt ttatccacca ttacgagtgg ctatatacac 420 ggatgagttg gaatttaaat ggccttaata gctagttagg actggaaaga aatgcatttt 480 aaatttctga taaatggccg cgattcacat acaagtaaaa tcagtctgtt taagagaata 540

68 taactaaacc gagctactaa tggattgaaa cctaggttct gagtggtgga caaaaaatct 600 taatagtttt cgaaacactt atttcattag gataccatat acttaaatta atttctccag 660 tttaaagttg attgcaaaaa tgcctaatta aatgtttcag gtaagttttt tggaaatata 720 aaacctttgt accaatatca aattataatg ggttctttag ttaaaattta ataaaaatca 780 aaatcttgaa tagattcaat tacccatttt gacactttag atttttaatt ttagagttaa 840 ttaaatgccg tataaatgtt atcttaacta tagattgcga agtagaaata ggtttgaaat 900 tcgtagcgta gacttggcgt acttacgact agaaacatac atttggcttt acccatgcct 960 ggtataacta tcgaacttat tgtctaagcc tctggtgcct tcacaggatg tccgtgttcc 1020 cctttagaga aactccgcgt cgctaaagga cgtgggacca tgaatcgaga acgcggatct 1080 tttccggctg gtgtgggcca gctatcatac ctccgacatg gctggcacgg taaccacctt 1140 ggtgggacgt tcgcagatta ccacacgggc gttcgtcttg ttggtggacc ttcgggaaac 1200 cgtcaacgaa gtggtcagtg tcctcatcga atcgcaactg ttgtgaagcc gacgaccaac 1260 cgtgtggcag cggttttgct gcgagttgtt gcggtatgac ttgcagcagc atgtgaacca 1320 cttaaaaggc ggaaagcgac tggaaatata ataaaaataa aaatatcaaa gtaagtaaat 1380 taaagcataa gaaaatgtgt aagatttttt aacatgaaat cttaacatac cttaatgtgc 1440 gaaagacctg cgatgagaag aggcaataga ttagtggatt cgccgccgag ttcagcggtg 1500 ccagactttg gatgaaggtg gcgatggcaa tgttggtctg tgagtgtgga atctggccaa 1560 agacctgcag cagatcgaag atgatatacg gcgaccagca gatgatgaac acaaacacga 1620 tggtcaatgt catcttgacc gttttgacct ttgcccgtgg aataatgccc ctcgagctgg 1680 ccctcctggc aggtgcagct ccaaaaccag cacgttctgt taaaatataa ttaacaaata 1740 aaataaaatt atttttggga actccgattt ggcaatatgc atagccagaa gatatcttac 1800 ccgtgggtac aaaaatggaa ccctttgccc aaatcgtctt tacgatgatc gcatagcagg 1860 cagatatgat cagcgcagga atggcaaata gagtggccga caccaggctc atgtacacct 1920 gccaggcgat cggtgaaccc aactcaatcc agcattgcgg atgtccttgg atgagcttct 1980 cctcgtacaa aaccaggatg ggaagcgaaa acaacgccga gatgagccat gcgccagcca 2040 ccaggtgacg ggctcttttc cctaaaagca taaaatttaa atatatattt aagtgaaata 2100 tatttctaat ttaacttaaa tttgtatatt ttttttggtt aattcccgaa ctaaattatc 2160 caagcagtgt aagcagaagc cacaaacagc gctcatcttt ggctaacaac atttggcaat 2220 tagaaaactt ttcatacgac gacttaactt acacgacttt gagaagttca tggggtgtgt 2280 gatggcatcg tatctgtcga tgctcatggc caccagcacg taggtggacg agtatgtgac 2340 gcagacctgc gagaagcgga tggccttgca ggccaggttg cctgcccgcc acgaaatcgt 2400 gatgcgccat atgatgtcgg tgaggacgtt gagcagtccc acgcacagat ctggaaataa 2460 tggactgggc attagaagca agggaagagg tcagtcccaa tcccaaaact cacctgccaa 2520 tgccagctgt ttaatgaagt agttcatccg cgacttgcga ttcttgttga tgaacatcac 2580 gaacagaaca gctgaattgc ccagaacgat gacggtgaac aggatccaga gcacagcaaa 2640 ctgttcggtc tggaagagtg caaagaacaa agtgtggtca catttcatta aacgcctatc 2700 aagttcattg tcaacaaagt gttaagcacg gaaatcacgc ataaaactca atttaatgcc 2760 atccaagcac acacacacac acacgccttg tttatggctc tttaaatagc cataaaaatg 2820 atagagctat gaattcaagc tggttggtgc ggcgggcagg atgtgccggc ggaagtttgc 2880 ttcttccagt tcagtactaa caagactagg acaacacgac atcctgcact caaacacccg 2940 tggacgctca cccacacacc cagacgtgat ggaagacaga cagccaccgt tattccagca 3000 ggaaattgct gccaagatga aggacctgca cttcgaaaaa tatttctttc gacttttaag 3060 gcagtttcac agctcaaaat gcgtggcttg gtatttaatt tatagaactt atactccagg 3120 cattcgaaat tcaattcata gcactcaaat ctaaaattgt aacaattctt atatagaaaa 3180 ctagtagata aagaataatg aacccttatt acttttactt ttttaactga actgttatta 3240 ttttaaaaat attttaaaca gtgtgaagtg cagatatgac agtgagtagt tctgctagtt 3300 ctagcttatt gccgaagaaa atgaaatatt ctttatacgc ccgcatgcag tttatatagc 3360 agaatatcgc atatatgcta atatgactaa tgatctcttc atggtatcta caaagttttt 3420 tgctgcaaat taaatttgct ctcaaggcat ctccccctat gcccacgtct attgaagtta 3480 agtttgaatt atggcctcgg ggtcttgcag tctgacgcca acaccgatgt tgatgcggac 3540 ttacttaagg gcaggccaag taaacttgtc ccgaaaaaaa agctgaaatc ctgacaggct 3600 tcgtccttgg aactgcgctc agactgaaga cgccccacct tattctacaa ctttttgtcc 3660 ataccaaact tgcagtattc actttttg 3688

<210> 47 <211> 1191 <212> DNA <213> Drosophila

<400> 47

69 atgaaatgtg accacacttt gttctttgca ctcttccaga ccgaacagtt tgctgtgctc 60 tggatcctgt tcaccgtcat cgttctgggc aattcagctg ttctgttcgt gatgttcatc 120 aacaagaatc gcaagtcgcg gatgaactac ttcattaaac agctggcatt ggcagatctg 180 tgcgtgggac tgctcaacgt cctcaccgac atcatatggc gcatcacgat ttcgtggcgg 240 gcaggcaacc tggcctgcaa ggccatccgc ttctcgcagg tctgcgtcac atactcgtcc 300 acctacgtgc tggtggccat gagcatcgac agatacgatg ccatcacaca ccccatgaac 360 ttctcaaagt cgtggaaaag agcccgtcac ctggtggctg gcgcatggct catctcggcg 420 ttgttttcgc ttcccatcct ggttttgtac gaggagaagc tcatccaagg acatccgcaa 480 tgctggattg agttgggttc accgatcgcc tggcaggtgt acatgagcct ggtgtcggcc 540 actctatttg ccattcctgc gctgatcata tctgcctgct atgcgatcat cgtaaagacg 600 atttgggcaa agggttccat ttttgtaccc acggaacgtg ctggttttgg agctgcacct 660 gccaggaggg ccagctcgag gggcattatt ccacgggcaa aggtcaaaac ggtcaagatg 720 acattgacca tcgtgtttgt gttcatcatc tgctggtcgc cgtatatcat cttcgatctg 780 ctgcaggtct ttggccagat tccacactca cagaccaaca ttgccatcgc caccttcatc 840 caaagtctgg caccgctgaa ctcggcggcg aatccactaa tctattgcct cttctcatcg 900 caggtctttc gcacattaag tcgctttccg ccttttaagt ggttcacatg ctgctgcaag 960 tcataccgca acaactcgca gcaaaaccgc tgccacacgg ttggtcgtcg gcttcacaac 1020 agttgcgatt cgatgaggac actgaccact tcgttgacgg tttcccgaag gtccaccaac 1080 aagacgaacg cccgtgtggt aatctgcgaa cgtcccacca aggtggttac cgtgccagcc 1140 atgtcggagc gacgcggagt ttctctaaag gggaacacgg acatcctgtg a 1191

<210> 48 <211> 396 <212> PRT <213> Drosophila

<400> 48

Met Lys Cys Asp His Thr Leu Phe Phe Ala Leu Phe Gin Thr Glu Gin

1 5 10 15

Phe Ala Val Leu Trp He Leu Phe Thr Val He Val Leu Gly Asn Ser 20 25 30

Ala Val Leu Phe Val Met Phe He Asn Lys Asn Arg Lys Ser Arg Met 35 40 45

Asn Tyr Phe He Lys Gin Leu Ala Leu Ala Asp Leu Cys Val Gly Leu 50 55 60

Leu Asn Val Leu Thr Asp He He Trp Arg He Thr He Ser Trp Arg

65 70 75 80

Ala Gly Asn Leu Ala Cys Lys Ala He Arg Phe Ser Gin Val Cys Val 85 90 95

Thr Tyr Ser Ser Thr Tyr Val Leu Val Ala Met Ser He Asp Arg Tyr 100 105 110

Asp Ala He Thr His Pro Met Asn Phe Ser Lys Ser Trp Lys Arg Ala 115 120 125

Arg His Leu Val Ala Gly Ala Trp Leu He Ser Ala Leu Phe Ser Leu 130 135 140

Pro He Leu Val Leu Tyr Glu Glu Lys Leu He Gin Gly His Pro Gin

145 150 155 160

Cys Trp He Glu Leu Gly Ser Pro He Ala Trp Gin Val Tyr Met Ser 165 170 175

Leu Val Ser Ala Thr Leu Phe Ala He Pro Ala Leu He He Ser Ala 180 185 190

Cys Tyr Ala He He Val Lys Thr He Trp Ala Lys Gly Ser He Phe 195 200 205

Val Pro Thr Glu Arg Ala Gly Phe Gly Ala Ala Pro Ala Arg Arg Ala 210 215 220

Ser Ser Arg Gly He He Pro Arg Ala Lys Val Lys Thr Val Lys Met

225 230 235 240

Thr Leu Thr He Val Phe Val Phe He He Cys Trp Ser Pro Tyr He 245 250 255

He Phe Asp Leu Leu Gin Val Phe Gly Gin He Pro His Ser Gin Thr

70 260 265 270

Asn He Ala He Ala Thr Phe He Gin Ser Leu Ala Pro Leu Asn Ser 275 280 285

Ala Ala Asn Pro Leu He Tyr Cys Leu Phe Ser Ser Gin Val Phe Arg 290 295 300

Thr Leu Ser Arg Phe Pro Pro Phe Lys Trp Phe Thr Cys Cys Cys Lys

305 310 315 320

Ser Tyr Arg Asn Asn Ser Gin Gin Asn Arg Cys His Thr Val Gly Arg 325 330 335

Arg Leu His Asn Ser Cys Asp Ser Met Arg Thr Leu Thr Thr Ser Leu 340 345 350

Thr Val Ser Arg Arg Ser Thr Asn Lys Thr Asn Ala Arg Val Val He 355 360 365

Cys Glu Arg Pro Thr Lys Val Val Thr Val Pro Ala Met Ser Glu Arg 370 375 380

Arg Gly Val Ser Leu Lys Gly Asn Thr Asp He Leu

385 390 395

<210> 49 <211> 5051 <212> DNA <213> Drosophila

<400> 49 ttccaatgcg atttaaggta attgactata agtacccatg acgaacttct ggacagttcc 60 ccagtggaaa aaaaaaactg gatttatttc ttatcgcaaa acttgcgata accaatttgt 120 atatgttcat tcagggagcg tgccgatttt ttagtttgcg aaattgagtt gttatgtttt 180 ctgagtcatt gtcgagcggg ttttggtagc cggggattaa atctgctgta tcatcttggt 240 ccagcgttta tttctatttg cttttaattt cacaatcaaa acagcaataa taaaaccgtg 300 ccttatctta cggacatatc tccccaagcg tcgtctcgct ctaatttgga tttttcctct 360 ctctctcgct cttttcttgc agctggcgcc cgacggtggg aatttcatca gctgttgttg 420 ttgttcattt cacagcagca gtcggcctaa taaaaatgca atttttatgg ttaagaaaat 480 agtgcgcgaa cgccgttgtg ttgcacattg gaaattgtgc agaagccaga agaaaatgtg 540 tcttggaaaa tggaaaagca cgagcagcag tagcaccagc agcagctata acattgagcc 600 agtgatgtaa tacagagcaa aagtgaagcg gcggcaattg gcattgcaaa aaagaaacag 660 attatacaat ttgtgttgct gccgcactga actaggacaa cagcagcaac aacagcagca 720 gcaacaacaa ccactagtga taaagaccgg ctggcaacag tgcagcggcc acttgcagca 780 acataatttc aaagtcggag cgtgggaatc gcaaatcacg gcagtggcag caacaacagc 840 aactgcagca acactcgagc actcgtggct ctccggatcg ctcatttcgc tcgccgttct 900 cgcgctggcg tttctccgtt tcgctcgcac ccgcctgtgg agcagtcgcg tatatttgga 960 ggcgttgggg cgaacgctca cgacagttgt gcttggaacg cttcggagtg aagatcgtgc 1020 tcgtccgatc ggtgcgcgtg ataaatacac ggcgaacaaa attgagtcaa gagtcagacg 1080 gtcgcaagac aattgacaag acacgaaaaa tcataataaa cacaagtgga aaagcaactg 1140 cttgagagca aaaaagaaat tgttttttac aaatctcgca cgtaaattag caagcgttcg 1200 caagaaacaa accgcataca atactgaaca caaaaaaaag ggtattcaac aaaaaaccaa 1260 aaatatttgg ctgcaaatgt gaagagacga gagacagcgg atatactacc gagtgaaatt 1320 tgtgtcataa gcagagccaa aacaaaaccg aaaagccaaa ttcaataaaa ggccataagt 1380 gactgtgaaa ctgtaaagtg atgtgtggta atcgaaaaac agcataaaga atggccatag 1440 acctcctgat cctggccctg ctgctcgtct cgttcctgat caacctgctg gcgctgtgtg 1500 ccttttggat aacgcctggc ttgaggacca ccgccaatcg ctttacgatc aacctgctgg 1560 ccatcaatct cattggttgc tgcatcttgg cccccacttt gttcctggga ctgccgggaa 1620 agtctgcgga ggcatccact tccaacgccg agaccctgga gttcttctcg aagccgggaa 1680 accatcaggt gatacttcgt cgcaatggcc agctggtgga acaggacggc gtggtggtgc 1740 gaaggaacat cagcgaaaac ggcgatacgg tggagacctt cttcaagtgc aatgccacct 1800 actgtcgcga gttgaccatc gatgagcgcg gagatggtgg ctttgtcatc acggaaaccg 1860 agacacacga agagaatctc tcggcctttg agagcttacc cacggaggct cccattttgc 1920 cgcccgtcca actgagatgt tggtccatag acatgactgc tgcgctggga gctctggcag 1980 tactgctcgt ggtgggggac acctggtgtg ccgttacgga tcccctgcgc taccacagtc 2040 gcatttcggg cgtgaaaacc tggatcttca tagcactcac ctgggtggtg ggcatactct 2100

71 ttggagccct ttccgccttc cgagttttgg actttgaggc ggacgccctg ttcagcagac 2160 aacgccgcct ggcagtcacg tacttcaaca tcagcagcac caatagtatt ttcggagtgg 2220 tgtacgccag tgtctacttc atcgtgatca tcctcctgcc cttcggcttc gtgtgcggaa 2280 tgtactggag gatattcagt gaggcgcgcg gaaatgggct gcgcatgcgc cagaatggct 2340 cttcgccgct gctgcagagc gccttgaatc tgacggctgg ccagcaggcg gctcaagcca 2400 accagttctc caatagcttg tgtgttcatc ggcattccat atcctcggcc agttcgcatg 2460 gcggcaacag cagcttgggc ttgggcggtc tgcaaatgca aattgatcag cgccaacagc 2520 cgaggagttc gcccagttgt ctccgtcggg actcggccgc gaaagtactt ttgcccacca 2580 tctcggatga tggtggctca gatgcggaaa gtggagccgg agttcaactg atgcccgtac 2640 aggagcactc actgtcagat agaaatcaga acattatgct tactctgcaa acagccagtg 2700 gtgaaataaa gaggaactac tccgccagac agctgcccct gttgggcact tcttcgcagg 2760 atctgaggga gactaatcgt ctgcagggca tacgccaggt gcacagttcg cccaatctcc 2820 acaagtacac ggaactgcgc caggactcgc tcagtgagga gtgtggttct ccgcatcttt 2880 tgggtcacgc ccagcggcag cagcagcagc aattgcacct gcaacatcag cagcaacagc 2940 atcatcacca ccagcaacat catccgcact tcagttcgcc gcgccaccag caacacggcc 3000 acgccctcca gatacccgcc attcatgcct cccccaaggc tctgagttac atgagctcct 3060 tgcgacaccg tttgagcaac gccagttcgc tattcaaata ccgtgaggag tcgagagcag 3120 cccgcatcag catcctggtg gtggtgatgt ttgtggtctc gtacctgccc ttcggactgc 3180 tggtactcct gcaatcgcga ctgtcggctg ctaactttgg cggatcctcc cagctggcca 3240 tcttcatgat cctgctggcc aatctcagtt cgccattcat cttcgcctac aggaacaaga 3300 gggtgaggcg aggagtcaag cggctgtttg gtctggattc gtcgtcgggc ctgcagcgca 3360 actgcagcag cagtgtaaag accaatggca ccgcaggtcc tgctgcaagt ggtgcacaat 3420 tgcagcgcaa cagcagcaag ttgtcgcagt acagcagcaa cagctgcaag tatctcaccc 3480 cccagagttc cctggtcagt caagtgccgg tgcatacgac cttgacgtta aggcccaaca 3540 gcagctgcag caccatcatc aatttcggtg gcgccagggg ctcagcggac tccgatgagc 3600 agccaccggc aacaccacca cctactgtgg cagttgctcc accgcccaca cgaccgcagc 3660 gccccaagct gcagaggggc atcaccatcg ttgagcacat agctataaca ccaaccatgc 3720 cccaaaagtt ccagaatcgg cgcgccaggc tcttcgacat gttcttccgc agctccaaga 3780 aactgcaggc gggctgccag agccagagtt tgcccactga ggtctaaacg gggggttatg 3840 ataactatac atataggaag gtaaacaaac actaaacttg cttgctgaag aattctaaga 3900 acagtattcg taatttgtaa gtctagcaat taacaaagac aactgtttga atttgagttt 3960 taagaccaga tcatgctgtc ctagaagctt ctcatgccaa aaaacaaaac cacaaagaaa 4020 gtcaaactag aaagtttgag atgctttaaa ttaacaaaaa aagaaaagaa aaaaacaaaa 4080 aacaaaacaa agtacctttt aaaaaataga aaactgtgta caagtcaaat taacaaagat 4140 tgagagtgat gggagttata atcttagggt ggatatcaaa ctgaaaagtg gaaccaagcc 4200 aagccaagtt gagatcgtaa tcaatgtacc taagcaactt gcatatgaac atttaatgtt 4260 tttactcaga tgaaatcaca ggaaaatagc aaagacagca cagcttattc gaacttcccc 4320 aactagttta ttatttattg aaacaattgt aaatatttat tagacatcca cgccgcaaag 4380 ctttaactcc aaaaacattc tggctaaaca agaagagacg catacattcg attcataagt 4440 taattaagtc aatgtgcaaa gcatatgtgt attctagagt ttaagttgta gagccgagta 4500 gtcttacacc gagcacctag tgccgagcag tgctttttca cctgcccaac tggagcgtct 4560 gttgcaggcg gcattttcat attgaaaatg cattttggcc agtgcacagt tggttttcca 4620 gttggccaga atgtcagtca gcagttagtt agcctttggt tagccaacgg ctattgggcc 4680 attaagtcaa tttgcttttt agaacaccgc gggcattgcg tgcagctaaa tacctcatta 4740 gttataattt gaagtgcgag atggatggcg gcaataggtc aaaggtcgga gccatcggca 4800 cggcccatgc ataatgcatg gaaaatgttc gattgcccct ggcatttgta tcatttgctt 4860 tactatgctg caggccagaa agctttatac cttaagttct cctgctttga tttcccttgg 4920 ctgcacaaaa aggcaacaaa agcaacacac actcacacaa cacaaaaaaa cctcgaattt 4980 atatttctaa agtttatatt ttataaagag tgtgtgcata ggaaatatct ataaatattc 5040 atgcatgtgt g 5051

<210> 50 <211> 3051 <212> DNA <213> Drosophila

<400> 50 cttcggagtg aagatcgtgc tcgtccgatc ggtgcgcgtg ataaatacac ggcgaacaaa 60

72 attgagtcaa gagtcagacg gtcgcaagac aattgacaag acacgaaaaa tcataataaa 120 cacaagtgga aaagcaactg cttgagagca aaaaagaaat tgttttttac aaatctcgca 180 cgtaaattag caagcgttcg caagaaacaa accgcataca atactgaaca caaaaaaaag 240 ggtattcaac aaaaaaccaa aaatatttgg ctgcaaatgt gaagagacga gagacagcgg 300 atatactacc gagtgaaatt tgtgtcataa gcagagccaa aacaaaaccg aaaagccaaa 360 ttcaataaaa ggccataagt gactgtgaaa ctgtaaagtg atgtgtggta atcgaaaaac 420 agcataaaga atggccatag acctcctgat cctggccctg ctgctcgtct cgttcctgat 480 caacctgctg gcgctgtgtg ccttttggat aacgcctggc ttgaggacca ccgccaatcg 540 ctttacgatc aacctgctgg ccatcaatct cattggttgc tgcatcttgg cccccacttt 600 gttcctggga ctgccgggaa agtctgcgga ggcatccact tccaacgccg agaccctgga 660 gttcttctcg aagccgggaa accatcaggt gatacttcgt cgcaatggcc agctggtgga 720 acaggacggc gtggtggtgc gaaggaacat cagcgaaaac ggcgatacgg tggagacctt 780 cttcaagtgc aatgccacct actgtcgcga gttgaccatc gatgagcgcg gagatggtgg 840 ctttgtcatc acggaaaccg agacacacga agagaatctc tcggcctttg agagcttacc 900 cacggaggct cccattttgc cgcccgtcca actgagatgt tggtccatag acatgactgc 960 tgcgctggga gctctggcag tactgctcgt ggtgggggac acctggtgtg ccgttacgga 1020 tcccctgcgc taccacagtc gcatttcggg cgtgaaaacc tggatcttca tagcactcac 1080 ctgggtggtg ggcatactct ttggagccct ttccgccttc cgagttttgg actttgaggc 1140 ggacgccctg ttcagcagac aacgccgcct ggcagtcacg tacttcaaca tcagcagcac 1200 caatagtatt ttcggagtgg tgtacgccag tgtctacttc atcgtgatca tcctcctgcc 1260 cttcggcttc gtgtgcggaa tgtactggag gatattcagt gaggcgcgcg gaaatgggct 1320 gcgcatgcgc cagaatggct cttcgccgct gctgcagagc gccttgaatc tgacggctgg 1380 ccagcaggcg gctcaagcca accagttctc caatagcttg tgtgttcatc ggcattccat 1440 atcctcggcc agttcgcatg gcggcaacag cagcttgggc ttgggcggtc tgcaaatgca 1500 aattgatcag cgccaacagc cgaggagttc gcccagttgt ctccgtcggg actcggccgc 1560 gaaagtactt ttgcccacca tctcggatga tggtggctca gatgcggaaa gtggagccgg 1620 agttcaactg atgcccgtac aggagcactc actgtcagat agaaatcaga acattatgct 1680 tactctgcaa acagccagtg gtgaaataaa gaggaactac tccgccagac agctgcccct 1740 gttgggcact tcttcgcagg atctgaggga gactaatcgt ctgcagggca tacgccaggt 1800 gcacagttcg cccaatctcc acaagtacac ggaactgcgc caggactcgc tcagtgagga 1860 gtgtggttct ccgcatcttt tgggtcacgc ccagcggcag cagcagcagc aattgcacct 1920 gcaacatcag cagcaacagc atcatcacca ccagcaacat catccgcact tcagttcgcc 1980 gcgccaccag caacacggcc acgccctcca gatacccgcc attcatgcct cccccaaggc 2040 tctgagttac atgagctcct tgcgacaccg tttgagcaac gccagttcgc tattcaaata 2100 ccgtgaggag tcgagagcag cccgcatcag catcctggtg gtggtgatgt ttgtggtctc 2160 gtacctgccc ttcggactgc tggtactcct gcaatcgcga ctgtcggctg ctaactttgg 2220 cggatcctcc cagctggcca tcttcatgat cctgctggcc aatctcagtt cgccattcat 2280 cttcgcctac aggaacaaga gggtgaggcg aggagtcaag cggctgtttg gtctggattc 2340 gtcgtcgggc ctgcagcgca actgcagcag cagtgtaaag accaatggca ccgcaggtcc 2400 tgctgcaagt ggtgcacaat tgcagcgcaa cagcagcaag ttgtcgcagt acagcagcaa 2460 cagctgcaag tatctcaccc cccagagttc cctggtcagt caagtgccgg tgcatacgac 2520 cttgacgtta aggcccaaca gcagctgcag caccatcatc aatttcggtg gcgccagggg 2580 ctcagcggac tccgatgagc agccaccggc aacaccacca cctactgtgg cagttgctcc 2640 accgcccaca cgaccgcagc gccccaagct gcagaggggc atcaccatcg ttgagcacat 2700 agctataaca ccaaccatgc cccaaaagtt ccagaatcgg cgcgccaggc tcttcgacat 2760 gttcttccgc agctccaaga aactgcaggc gggctgccag agccagagtt tgcccactga 2820 ggtctaaacg gggggttatg ataactatac atataggaag gtaaacaaac actaaacttg 2880 cttgctgaag aattctaaga acagtattcg taatttgtaa gtctagcaat taacaaagac 2940 aactgtttga atttgagttt taagaccaga tcatgctgtc ctagaagctt ctcatgccaa 3000 aaaacaaaac cacaaagaaa gtcaaactag aaagtttgag atgctttaaa t 3051

<210> 51 <211> 798 <212> PRT <213> Drosophila

<400> 51

Met Ala He Asp Leu Leu He Leu Ala Leu Leu Leu Val Ser Phe Leu

1 5 10 15

He Asn Leu Leu Ala Leu Cys Ala Phe Trp He Thr Pro Gly Leu Arg

73 20 25 30

Thr Thr Ala Asn Arg Phe Thr He Asn Leu Leu Ala He Asn Leu He

35 40 45

Gly Cys Cys He Leu Ala Pro Thr Leu Phe Leu Gly Leu Pro Gly Lys

50 55 60

Ser Ala Glu Ala Ser Thr Ser Asn Ala Glu Thr Leu Glu Phe Phe Ser 65 70 75 80

Lys Pro Gly Asn His Gin Val He Leu Arg Arg Asn Gly Gin Leu Val

85 90 95

Glu Gin Asp Gly Val Val Val Arg Arg Asn He Ser Glu Asn Gly Asp

100 105 110

Thr Val Glu Thr Phe Phe Lys Cys Asn Ala Thr Tyr Cys Arg Glu Leu

115 120 125

Thr He Asp Glu Arg Gly Asp Gly Gly Phe Val He Thr Glu Thr Glu

130 135 140

Thr His Glu Glu Asn Leu Ser Ala Phe Glu Ser Leu Pro Thr Glu Ala 145 150 155 160

Pro He Leu Pro Pro Val Gin Leu Arg Cys Trp Ser He Asp Met Thr

165 170 175

Ala Ala Leu Gly Ala Leu Ala Val Leu Leu Val Val Gly Asp Thr Trp

180 185 190

Cys Ala Val Thr Asp Pro Leu Arg Tyr His Ser Arg He Ser Gly Val

195 200 205

Lys Thr Trp He Phe He Ala Leu Thr Trp Val Val Gly He Leu Phe

210 215 220

Gly Ala Leu Ser Ala Phe Arg Val Leu Asp Phe Glu Ala Asp Ala Leu 225 230 235 240

Phe Ser Arg Gin Arg Arg Leu Ala Val Thr Tyr Phe Asn He Ser Ser

245 250 255

Thr Asn Ser He Phe Gly Val Val Tyr Ala Ser Val Tyr Phe He Val

260 265 270

He He Leu Leu Pro Phe Gly Phe Val Cys Gly Met Tyr Trp Arg He

275 280 285

Phe Ser Glu Ala Arg Gly Asn Gly Leu Arg Met Arg Gin Asn Gly Ser

290 295 300

Ser Pro Leu Leu Gin Ser Ala Leu Asn Leu Thr Ala Gly Gin Gin Ala 305 310 315 320

Ala Gin Ala Asn Gin Phe Ser Asn Ser Leu Cys Val His Arg His Ser

325 330 335

He Ser Ser Ala Ser Ser His Gly Gly Asn Ser Ser Leu Gly Leu Gly

340 345 350

Gly Leu Gin Met Gin He Asp Gin Arg Gin Gin Pro Arg Ser Ser Pro

355 360 365

Ser Cys Leu Arg Arg Asp Ser Ala Ala Lys Val Leu Leu Pro Thr He

370 375 380

Ser Asp Asp Gly Gly Ser Asp Ala Glu Ser Gly Ala Gly Val Gin Leu 385 390 395 400

Met Pro Val Gin Glu His Ser Leu Ser Asp Arg Asn Gin Asn He Met

405 410 415

Leu Thr Leu Gin Thr Ala Ser Gly Glu He Lys Arg Asn Tyr Ser Ala

420 425 430

Arg Gin Leu Pro Leu Leu Gly Thr Ser Ser Gin Asp Leu Arg Glu Thr

435 440 445

Asn Arg Leu Gin Gly He Arg Gin Val His Ser Ser Pro Asn Leu His

450 455 460

Lys Tyr Thr Glu Leu Arg Gin Asp Ser Leu Ser Glu Glu Cys Gly Ser 465 470 475 480

Pro His Leu Leu Gly His Ala Gin Arg Gin Gin Gin Gin Gin Leu His

485 490 495

Leu Gin His Gin Gin Gin Gin His His His His Gin Gin His His Pro

74 500 505 510

His Phe Ser Ser Pro Arg His Gin Gin His Gly His Ala Leu Gin He

515 520 525

Pro Ala He His Ala Ser Pro Lys Ala Leu Ser Tyr Met Ser Ser Leu

530 535 540

Arg His Arg Leu Ser Asn Ala Ser Ser Leu Phe Lys Tyr Arg Glu Glu 545 550 555 560

Ser Arg Ala Ala Arg He Ser He Leu Val Val Val Met Phe Val Val

565 570 575

Ser Tyr Leu Pro Phe Gly Leu Leu Val Leu Leu Gin Ser Arg Leu Ser

580 585 590

Ala Ala Asn Phe Gly Gly Ser Ser Gin Leu Ala He Phe Met He Leu

595 600 605

Leu Ala Asn Leu Ser Ser Pro Phe He Phe Ala Tyr Arg Asn Lys Arg

610 615 620

Val Arg Arg Gly Val Lys Arg Leu Phe Gly Leu Asp Ser Ser Ser Gly 625 630 635 640

Leu Gin Arg Asn Cys Ser Ser Ser Val Lys Thr Asn Gly Thr Ala Gly

645 650 655

Pro Ala Ala Ser Gly Ala Gin Leu Gin Arg Asn Ser Ser Lys Leu Ser

660 665 670

Gin Tyr Ser Ser Asn Ser Cys Lys Tyr Leu Thr Pro Gin Ser Ser Leu

675 680 685

Val Ser Gin Val Pro Val His Thr Thr Leu Thr Leu Arg Pro Asn Ser

690 695 700

Ser Cys Ser Thr He He Asn Phe Gly Gly Ala Arg Gly Ser Ala Asp 705 710 715 720

Ser Asp Glu Gin Pro Pro Ala Thr Pro Pro Pro Thr Val Ala Val Ala

725 730 735

Pro Pro Pro Thr Arg Pro Gin Arg Pro Lys Leu Gin Arg Gly He Thr

740 745 750

He Val Glu His He Ala He Thr Pro Thr Met Pro Gin Lys Phe Gin

755 760 765

Asn Arg Arg Ala Arg Leu Phe Asp Met Phe Phe Arg Ser Ser Lys Lys

770 775 780

Leu Gin Ala Gly Cys Gin Ser Gin Ser Leu Pro Thr Glu Val 785 790 795

<210> 52 <211> 3919 <212> DNA <213> Drosophila

<400> 52 attctattgt cgtaggcgtg gcaaaaggtt ttttggtaaa tcgatagaaa tgtacaagag 60 aatgtaatta atatgaaaag gtaacaaaaa attttgcaaa agtgtgggca tggcagtttt 120 ggtcggtttg ttggcgtaag ggcattatcg gtattttcct attttcagct atatgatgca 180 gtcgcctaat tttgatcaaa ctataactaa aattgtatat tgtcagaaac aacgagcatg 240 aatttatagt caatttatct ttttattatt tcttatctaa agttatatgc atatagaata 300 aaaacagata cgagcttcct tagaagcgga cggaaataat gtctcgagat ctggaccttc 360 attaagacag acgaacatta ggacaaggcc aggtctactc agctagggat cctgatcaat 420 gtatatgtat ttactttaaa ggggcgtaaa cttgtatttt acatgttaca tactttcaag 480 cgaatctagt aaaccctttt aatttacaag taacgaatat aaaaagttga atggtagcgg 540 gagaaaatta attgtataat ataatattat ctttgttaat ccagagtctt ggcaacttgt 600 gcacacaatt tttttttttt ttttggaaac tgaatcagtt aattgtgcca aaatttagag 660 tgtagatttc ttggaaatct caatgaattt tatggtcaag ttccaagaag tgaaatgctt 720 aacaaacaac aaaaacaaaa cacacaaaag caaacaaatt atgcagaatt atcggatgta 780 ttttatatgt atgtatgtac atacatatac aaagaataat aaatgggtgg gtctgttggc 840 ttctatggaa tttccaattt aagctgcaat acatgtacat tttaacgtct ttctgtacgc 900

75 tctcaaataa aaaaacacaa ttttaggatt aataaaaaaa cagatatgta cgtcttctat 960 tcccatatga agaaaaatat tcatatgatt ttttgtttgg caggaaatgc gaatagttat 1020 tggatcgttc accgcatttc ttttgctgtt attgcaaaac tcaaatgccg aaattcccgg 1080 ttgcgacttc ttcgacaccg tagatatttc aaaagcgcca agattctcga acggatcgta 1140 cctctacgaa ggcttgctga tccccgccca tttgacagct gaatatgact acaagctcct 1200 ggccgacgat tcgaaggaga aggtggcgag ccacgtacga ggatgtgcct gccacctcag 1260 gccatgcatt cggttttgtt gcccccagta ccaaaagatg caaaagagca agtgctacgg 1320 cgacatgtcg gaggacgagc tgaacaagca cgatcccttc gtgaacgtga cgctcagcga 1380 cgggtcggtg gtcaggagac acttcaagga ggatctgatc gtgcagtcgg atctggccaa 1440 gcccggatgt ccccggatgt actttctgaa tcacgaactg ccgggcaatg aattcactct 1500 gtttgaggtt actttcctgt gtttctgtca cttctgaaga tcgtaacctt ttttgaatct 1560 ctgtagaacg gctctcttct gcgtcactgg gacaaagtgg aactgagcaa gccgggagta 1620 ctgcgtccag catctttcat ttaaggatga tagtatccga attgcacccc acttctgtcc 1680 actttcgtct gagcactcca gaacgtggaa gaccgttggt aagctgaatt ccctgcttga 1740 ctttaaggtt tttagttaat gtccattttc acagcgatag tgatatcctt gatatgcata 1800 atcctaacga tcagcgtgta cctctatgtt gagaagcttc gcaacctgca cggaaagtgt 1860 ttcatctgct acttggcctc cttgttcctg ggatatttct tcctggtcct caacgtgtgg 1920 aaatactcct ccggcttctg cgttacagca ggtttgcttg tggcgattac aagataaagg 1980 acgaccaatt tcacatttcg atatcatgat cagggttcct gggctacttc tccgtcatcg 2040 ccgcgttctt ttggctttct gtcatcagtc ttaccctctg gaattcattt agcggcaact 2100 ccagctggtt gaaccgtttc ttgccacaga atcggttcct ttcttacaat ttatacgcct 2160 ggggcatggc gctgctcctg actgcaatca cctatatagc tgaccaggtg gttaagaacg 2220 agaagttgag accccgcgtg ggcgtcggca aaaattgttg gatctacagt aagttactat 2280 tcctataata acaattgcgg tgtaactcgt ttttttttta accaacagct ggggatatga 2340 ctgtcatgat ctacttctat ggcccgatgc tactgataat tgttttcaac ataacaatgt 2400 ttgtcctgac ggcttttcgt ataatgaaag tgaagaagga agcacaaaac tttactcaac 2460 agcaaaaaac aaccaatagg ctcaattcgg acaagcagac gtaataattt taccatattt 2520 tatacagttc taaatccaaa agtttaaatt ttaaattatt ttctatggct tttaaagtta 2580 cgccctattc ctgcgactct ttatcatcat gggcttgtcc tggagcttgg aaataatctc 2640 gtttttgttg agcaaaaatc aggcttgggc caaggctttt atggtggctg attacttcaa 2700 ttggtcacag ggcaccgtca tatttctgct atttgttctg aggcccagca cactgaagct 2760 actgaaggaa cggtaagtta tcggttcttc cataggaggt ccaattaacc tggttctatc 2820 atctggctga gcaggattaa gggtgggagg gatgaagccg gcgccagcga tgaacatatc 2880 tcacttcaga atacgaaaat tgaccccagt gttttttaat atatgggtaa tgtgaaaata 2940 cagtttatta gttcatttgg tgttggaaac cttctatttt gaatcactaa caggcagcct 3000 aatgatcgtg accaaaggct gctttgcttg ctcattattg ctcacatatc gtatgctcat 3060 atgggctacg aatatttgct acttatcact tttcaagtat cttgatttct gcacggtgtc 3120 taagcatatc taagttttaa ttaaatgttg aatgtaattg tcctttaagt tataactttt 3180 tgcaataata atctattcca atccatccta gacgtgccat caaagcgaga tcaaagcaac 3240 tactacatgg ggatatgtac gaatcttata ggcatgaata ctcggcattt atataccctg 3300 gtctattatt atggatggag gataaaaact caggaaaata cttttcgcat cagcacttat 3360 gtatgctcac tcgtgataat aatttcgtaa taattcgtac tgtttttact gcctcaactt 3420 aattcaaaga actacaaatg attatattat gactttttat gacaatgact aactaaaaat 3480 aaaaatttct gaatatttat aaacaacttt aaaatgttat taacttagga taataataat 3540 aacacagttt taatttatca agcacatcgt taaaaaacaa taaattactt gaatataaat 3600 ttaaaaaaaa aatggaatat tggtttacat taacggtatg caaaaaatca taaaaagtca 3660 tagaactgaa cgatagagaa aattacaaaa aaacgatcta gtcgagttcc tcgactataa 3720 gatactcatt tctcagctag ttctttcatt taaaaatttc tctttcgttt cgatagtaat 3780 tggcaagaaa aaataataaa atacaacaaa ttaatgcatt tttgaaaatt atgggcgtga 3840 ctgatttggt cggttagtgg acgtgtcaat attatgaagc aaacgtggac actacaaact 3900 gaaatatata tatatatat 3919

<210> 53

<211> 1547

<212> DNA

<213> Drosophila

<400> 53 caggaaatgc gaatagttat tggatcgttc accgcatttc ttttgctgtt attgcaaaac 60 tcaaatgccg aaattcccgg ttgcgacttc ttcgacaccg tagatatttc aaaagcgcca 120

76 agattctcga acggatcgta cctctacgaa ggcttgctga tccccgccca tttgacagct 180 gaatatgact acaagctcct ggccgacgat tcgaaggaga aggtggcgag ccacgtacga 240 ggatgtgcct gccacctcag gccatgcatt cggttttgtt gcccccagta ccaaaagatg 300 caaaagagca agtgctacgg cgacatgtcg gaggacgagc tgaacaagca cgatcccttc 360 gtgaacgtga cgctcagcga cgggtcggtg gtcaggagac acttcaagga ggatctgatc 420 gtgcagtcgg atctggccaa gcccggatgt ccccggatgt actttctgaa tcacgaactg 480 ccgggcaatg aattcactct gtttgagaac ggctctcttc tgcgtcactg ggacaaagtg 540 gaactgagca agccgggagt actgcgtcca gcatctttca tttaaggatg atagtatccg 600 aattgcaccc cacttctgtc cactttcgtc tgagcactcc agaattaatg tccattttca 660 cagcgatagt gatatccttg atatgcataa tcctaacgat cagcgtgtac ctctatgttg 720 agaagcttcg caacctgcac ggaaagtgtt tcatctgcta cttggcctcc ttgttcctgg 780 gatatttctt cctggtcctc aacgtgtgga aatactcctc cggcttctgc gttacagcag 840 ggttcctggg ctacttctcc gtcatcgccg cgttcttttg gctttctgtc atcagtctta 900 ccctctggaa ttcatttagc ggcaactcca gctggttgaa ccgtttcttg ccacagaatc 960 ggttcctttc ttacaattta tacgcctggg gcatggcgct gctcctgact gcaatcacct 1020 atatagctga ccaggtggtt aagaacgaga agttgagacc ccgcgtgggc gtcggcaaaa 1080 attgttggat ctacactggg gatatgactg tcatgatcta cttctatggc ccgatgctac 1140 tgataattgt tttcaacata acaatgtttg tcctgacggc ttttcgtata atgaaagtga 1200 agaaggaagc acaaaacttt actcaacagc aaaaaacaac caataggctc aattcggaca 1260 agcagactta cgccctattc ctgcgactct ttatcatcat gggcttgtcc tggagcttgg 1320 aaataatctc gtttttgttg agcaaaaatc aggcttgggc caaggctttt atggtggctg 1380 attacttcaa ttggtcacag ggcaccgtca tatttctgct atttgttctg aggcccagca 1440 cactgaagct actgaaggaa cggattaagg gtgggaggga tgaagccggc gccagcgatg 1500 aacatatctc acttcagaat acgaaaattg accccagtgt tttttaa 1547

<210> 54 <211> 192 <212> PRT <213> Drosophila

<400> 54

Met Arg He Val He Gly Ser Phe Thr Ala Phe Leu Leu Leu Leu Leu

1 5 10 15

Gin Asn Ser Asn Ala Glu He Pro Gly Cys Asp Phe Phe Asp Thr Val 20 25 30

Asp He Ser Lys Ala Pro Arg Phe Ser Asn Gly Ser Tyr Leu Tyr Glu 35 40 45

Gly Leu Leu He Pro Ala His Leu Thr Ala Glu Tyr Asp Tyr Lys Leu 50 55 60

Leu Ala Asp Asp Ser Lys Glu Lys Val Ala Ser His Val Arg Gly Cys

65 70 75 80

Ala Cys His Leu Arg Pro Cys He Arg Phe Cys Cys Pro Gin Tyr Gin 85 90 95

Lys Met Gin Lys Ser Lys Cys Tyr Gly Asp Met Ser Glu Asp Glu Leu 100 105 110

Asn Lys His Asp Pro Phe Val Asn Val Thr Leu Ser Asp Gly Ser Val 115 120 125

Val Arg Arg His Phe Lys Glu Asp Leu He Val Gin Ser Asp Leu Ala 130 135 140

Lys Pro Gly Cys Pro Arg Met Tyr Phe Leu Asn His Glu Leu Pro Gly

145 150 155 160

Asn Glu Phe Thr Leu Phe Glu Asn Gly Ser Leu Leu Arg His Trp Asp 165 170 175

Lys Val Glu Leu Ser Lys Pro Gly Val Leu Arg Pro Ala Ser Phe He 180 185 190

<210> 55 <211> 3640 <212> DNA

77 <213> Drosophila

<400> 55 aattaatgca tttttgaaaa ttatgggcgt gactgatttg gtcggttagt ggacgtgtca 60 atattatgaa gcaaacgtgg acactacaaa ctgaaatata tatatatata tcatttcatt 120 gcccttaagt ctgaaaaacg gctttaaaat tgagaagtta ctttaagaga tattcgaggt 180 attcggtgac agcagcgcac attatcgact ggccaatggg aatattagat ttgtagaata 240 gggtaatatg taaacgtaaa cctttcgatt gtataaagca ttcaattcct aatatggata 300 tgtccgttca ccagcctgta ttaactttgc gtgttattac ttaaatttat ctttctatgt 360 acatgccaga aactgataga atggcacggt taccgccgat agtcgctgag tatggggtat 420 cttatagtcg agcacattct cgttctccct tgacatcgca tatatcggtt gagttgttcg 480 cattttggga tcagtcatct taaaactctg gtcgcataaa catgtttttt gtgttagtcg 540 ttccatttga cccttgcgta agtatttata ttcaaagttt ttacgatttt ggatcgttaa 600 gcataagaag gaccactcga gtacgatttg accgttttta tacaatttcg tcctcttaga 660 cgaataaata ttgtgcctgc cttgtttcta aaaatgaact tgcttcagct tcgtagagaa 720 tgcttagtca taacagatgg atttgttgaa tttattttta acagttgata agttatactt 780 ttataaaaaa aaaaaaacaa cttactcaga atgctatagc acatgactca attttttgtt 840 tttcataagt atttagatca gttttcagtt ttgcggaggt tattttgcta ctttatttct 900 aattgtgaac acgtaacttg gtttaaaacc gtatatactt acagaatagc atacatcatt 960 tgaattcagt tgcctatcat attaatttcc tttgcagaaa atgcggatat tgttaattgc 1020 agttcttttt ctgttgatgc caaaatcaaa tgccgaaatt cccggttgcg acttcttcga 1080 caccgtagat atttcaaaag cgccaagatt ctcgaacgga tcgtacctct acgaaggctt 1140 gctgatcccc gcccatttga cagctgaata tgactacaag ctcctggccg acgattcgaa 1200 ggagaaggtg gcgagccacg tacgaggatg tgcctgccac ctcaggccat gcatccggtt 1260 ttgttgcccc cagtaccaaa agatgcaaaa gagcaagtgc tatggcgaca tgtcggagga 1320 cgagctgaac aagcacgatc ccttcgtgaa cgtgacgctc agcgacgggt cggtggtcag 1380 gagacacttc aaggaggatc tgatcgtgca gtcggatctg gccaagcccg gatgtccccg 1440 gatgtacttt ttgaatcacg aactgccggg caatgaattc actctgtttg aggttacttt 1500 cctgtgtttc tgtcacttct gaagatcgta accttttttg aatctctgta gaacggctct 1560 cttctgcgtc actgggacaa agtggaactg agcaagcggg agtactgcgt ccagcatctt 1620 tcatttaagg atgatagtat ccgaattgca ccccacttct gtccactttc gtctgagcac 1680 tccagaacgt ggaagaccgt tggtaagctg aattccctgc ttgactttaa ggtttttagt 1740 taatgtcctt tctcacagcg atagtgatat ccttgatatg cataatccta acgatcagcg 1800 tgtacctcta tgtcgagaag cttcgcaacc tgcacggaaa gtgtttcatc tgctacttgg 1860 cctctttgtt cttgggctat ttcttcctgg tcctcaacgt gtggaaatac tcctccggct 1920 tctgcgttac agcaggtttg cttgtggcga ttacaagata aaggacgact aatttcacat 1980 ttcgatatca tgatcagggt tcctgggcta cttctccgtc atggccgcgt tcttttggct 2040 ttctgtgatt ggaatccact tgcggattaa gtttagtcta gcctctaact gtttgcaccg 2100 attgctgcca gaaaatccgt tccgtgcata caacttatac gcctggggta taccgctaat 2160 catgactgca atcacctata cagctgacca ggtggttaag aacgagaagt tgagaccccg 2220 cgtgggcgtc ggcaaaaatt gttggatcta cagtaagtta ctattcctat aattacaatt 2280 acggtgtaac tcgttttgtt aaccaacagc tggcgatatg actgtcatga tctacttcta 2340 tggcccgatg ctgttgctaa tcgctttcaa cataataatg tttgtccttt cggcgattta 2400 catatataac ataaagaaaa atgtgaaagg ccttgtccac aagcaacaaa caaaccaaca 2460 gataaatgac caacaaatgt aattatatta tattataaga taataactat aatgtcaaat 2520 ggcacttttt gtaatctttt ataggtttgc tatattcctg cgacttttca tcttaatggg 2580 tttgtcgtgg agctttgaga tattatcctt tttgttaacc aaacagcaag cttgggctag 2640 ggctttaatg gtggctgact actttaattg gtcccagggt accatcatat tcgtgctttt 2700 tattttaaag cctagcattc taaaacttat aatagcaggg taagtaaagt attacaaata 2760 accttgaaat ttgaccgtct catacgtatg aacaatcttt tgatttaggg gacgtcaaaa 2820 cctcccagga agtcaccata attcgagatc aaaagcagct cgatataatt caactcatac 2880 ggcttgtgaa ggatcaattg cggatccaaa cgcttactgc taaaaaaatg gaattcaata 2940 agatgcaacg tctctgttat tgatcacatt attttaattt tctatggagc aaaagtttaa 3000 aaaaaatatt tgttatcaag acaataaata atgtcttgga acatataaag caaaatatat 3060 taaagggtac aaaaaacagg aaaagtatgg ggcaatacag caaaatattt ttcggatcat 3120 caactttttt gtaagacaaa atgtagaaat atttctggca ccgttgtttc aaaccagggt 3180 ttgagtcaac aatgctggcc caccactggc aagtaccaaa cgattacaga aaactttttc 3240 taatcgatta agcatcgggg gtcatcgatg tttctccacc actacaattt catgttgttt 3300 ttttagtcgc ggctgtttga cgtttgtcgc tttcctccgt tgcgaatata atatattacg 3360 tagctcattt ttatacaaac ggaattacga gcgcaacgac gacagcaaca ctagtagcac 3420

78 taatcgtaag cgcaggggcc aaaaattaaa ttgcgtttgc ggccgcaaag atttgatgac 3480 gtcgcatacg ccgtcttcta gggcgtaaaa agcaaagcaa agcaaacaaa cgcgaaagcg 3540 aaacgtgtaa acggcgtaga agcgataaac gcgactcaaa tacgcagcag ataaaataca 3600 atacgcgaga agagaaaagt cacgggaaat attgttcata 3640

<210> 56 <211> 1089 <212> DNA <213> Drosophila

<400> 56 atgcggatat tgttaattgc agttcttttt ctgttgatgc caaaatcaaa tgccgaaatt 60 cccggttgcg acttcttcga caccgtagat atttcaaaag cgccaagatt ctcgaacgga 120 tcgtacctct acgaaggctt gctgatcccc gcccatttga cagctgaata tgactacaag 180 ctcctggccg acgattcgaa ggagaaggtg gcgagccacg tacgaggatg tgcctgccac 240 ctcaggccat gcatccggtt ttgttgcccc cagtaccaaa agatgcaaaa gagcaagtgc 300 tatggcgaca tgtcggagga cgagctgaac aagcacgatc ccttcgtgaa cgtgacgctc 360 agcgacgggt cggtggtcag gagacacttc aaggaggatc tgatcgtgca gtcggatctg 420 gccaagcccg gatgtccccg gatgtacttt ttgaatcacg aactgccggg caatgaattc 480 actctgtttg agaacggctc tcttctgcgt cactgggaca aagtggaact gagcaagcgg 540 gagtactgcg tccagcatct ttcatttaag gatgatagta tccgaattgc accccacttc 600 tgtccacttt cgtctgagca ctccagaacg tggaagaccg ttgcgatagt gatatccttg 660 atatgcataa tcctaacgat cagcgtgtac ctctatgtcg agaagcttcg caacctgcac 720 ggaaagtgtt tcatctgcta cttggcctct ttgttcttgg gctatttctt cctggtcctc 780 aacgtgtgga aatactcctc cggcttctgc gttacagcag ggttcctggg ctacttctcc 840 gtcatggccg cgttcttttg gctttctgtg attggaatcc acttgcggat taagtttagt 900 ctagcctcta actgtttgca ccgattgctg ccagaaaatc cgttccgtgc atacaactta 960 tacgcctggg gtataccgct aatcatgact gcaatcacct atacagctga ccaggtggtt 1020 aagaacgaga agttgagacc ccgcgtgggc gtcggcaaaa attgttggat ctacacaagc 1080 ttgggctag 1089

<210> 57 <211> 362 <212> PRT <213> Drosophila

<400> 57

Met Arg He Leu Leu He Ala Val Leu Phe Leu Leu Met Pro Lys Ser

1 5 10 15

Asn Ala Glu He Pro Gly Cys Asp Phe Phe Asp Thr Val Asp He Ser

20 25 30

Lys Ala Pro Arg Phe Ser Asn Gly Ser Tyr Leu Tyr Glu Gly Leu Leu

35 40 45

He Pro Ala His Leu Thr Ala Glu Tyr Asp Tyr Lys Leu Leu Ala Asp

50 55 60

Asp Ser Lys Glu Lys Val Ala Ser His Val Arg Gly Cys Ala Cys His 65 70 75 80

Leu Arg Pro Cys He Arg Phe Cys Cys Pro Gin Tyr Gin Lys Met Gin

85 90 95

Lys Ser Lys Cys Tyr Gly Asp Met Ser Glu Asp Glu Leu Asn Lys His

100 105 110

Asp Pro Phe Val Asn Val Thr Leu Ser Asp Gly Ser Val Val Arg Arg

115 120 125

His Phe Lys Glu Asp Leu He Val Gin Ser Asp Leu Ala Lys Pro Gly

130 135 140

Cys Pro Arg Met Tyr Phe Leu Asn His Glu Leu Pro Gly Asn Glu Phe 145 150 155 160

Thr Leu Phe Glu Asn Gly Ser Leu Leu Arg His Trp Asp Lys Val Glu

165 170 175

Leu Ser Lys Arg Glu Tyr Cys Val Gin His Leu Ser Phe Lys Asp Asp

79 180 185 190

Ser He Arg He Ala Pro His Phe Cys Pro Leu Ser Ser Glu His Ser

195 200 205

Arg Thr Trp Lys Thr Val Ala He Val He Ser Leu He Cys He He

210 215 220

Leu Thr He Ser Val Tyr Leu Tyr Val Glu Lys Leu Arg Asn Leu His 225 230 235 240

Gly Lys Cys Phe He Cys Tyr Leu Ala Ser Leu Phe Leu Gly Tyr Phe

245 250 255

Phe Leu Val Leu Asn Val Trp Lys Tyr Ser Ser Gly Phe Cys Val Thr

260 265 270

Ala Gly Phe Leu Gly Tyr Phe Ser Val Met Ala Ala Phe Phe Trp Leu

275 280 285

Ser Val He Gly He His Leu Arg He Lys Phe Ser Leu Ala Ser Asn

290 295 300

Cys Leu His Arg Leu Leu Pro Glu Asn Pro Phe Arg Ala Tyr Asn Leu 305 310 315 320

Tyr Ala Trp Gly He Pro Leu He Met Thr Ala He Thr Tyr Thr Ala

325 330 335

Asp Gin Val Val Lys Asn Glu Lys Leu Arg Pro Arg Val Gly Val Gly

340 345 350

Lys Asn Cys Trp He Tyr Thr Ser Leu Gly 355 360

<210> 58 <211> 7503 <212> DNA <213> Drosophila

<400> 58 gattgccgtg gtcgtgcgcc gcgggagaaa tgcccttttc gtgtacgcaa ttactaggca 60 aaaaggtttg gacggccctt gctttattag gccataattt acgctgtcga gcggccatta 120 gagcggcatc cgctggccaa gttggtctat aaaagcccgg cggctgcaag tggcgttttc 180 cattccacgt gaaaggacac tcgcagtcgg gccgacgaga tgctgcgcca cctgctccgc 240 cacgagaaca acaaggtctt cgtcctgatc ctgctctact gcgtcctggt cagcattctg 300 aaactctgca cggcacagcc ggatagctct gtggccgcca cggataatgg tatttgataa 360 ggcatttgat aatatcatat tattcgctct aatggattcc atttaccatc cagatattac 420 gcatcttggc gacgattgtc aggtgacgcc cgtcatccat gtgctccagt atcctggatg 480 tgtgcccaag ccgattccct cgttcgcctg cgtgggtcgc tgtgccagtt atatccaggt 540 gggtgttgat atacttgaaa tataaattat aatttgatat aatctgatga ctttaggttt 600 cgggcagtaa gatctggcaa atggagcgtt cctgcatgtg ctgccaggag tctggtgagc 660 gggaggcagc cgtctcgcta ttctgtccca aagtgaagcc cggcgagcgt aaattcaaga 720 aggtcctgac caaggcgcca ttggagtgca tgtgtcggcc atgcacttcc attgaggagt 780 ctggcatcat accacaggaa attgccggct attcggacga gggtccactc aacaatcact 840 tccggcgcat tgctctgcaa tagattcccc catcagttta gcactcatac ccatgcccat 900 ttgctcatta aaataaatta gagttgccgt ttctgcttgt acacagtgaa aaatgtgcct 960 ctgaaagctc atgccagtga aagggaaaca tcagcagata tatgattatt ttaaattgta 1020 atttatttcc caactatctc atgtcattgc tactagttca ctaaatggtg tgtgtcctgc 1080 ttcacagggt atgtatgtag atgcgtaact ccaaagaaaa caaagataat ctttacactg 1140 caactggatc taacaatagg agtttaacta cggcataatg catatgactc gcgccgccta 1200 caagtactcg acgatatcgc atttgatgga tatattcgga cagctctggc ccacggcact 1260 gcggccccga tagttgggac tcttctcggt gaggagtttc cggaagatgg gcaaaattgc 1320 cgtctcgccc tcgagcagtt ccgtctcgct gctggcgccg tagatgctgc tatcctgctt 1380 gccgcgctgc ctgctccgct gcttatcggg cgccacattg ggcgaactgt ggtggtgggc 1440 ggcgtgctgg atgttagagc tccggctgac cttacgcggc tggacgcacg gctgactgtt 1500 gggcggcgga tctcgttccc gttcgctgtc cgtctcgctc tggcaaacgg tgcccttttg 1560 cggttttggc cgatgtttgt tgcggttctt ctcggagacg gaccgctgga tgggcgaggt 1620 ggtgttcggg tcataggtca tcccgtggcc gccatgatgt tccgcacagc gctgcggact 1680 ggcgtagttc cgcggcgact ggcgctgctt ggcgtgcgac agcgtgtgcg tgtcccagag 1740

80 gtcactctgt gaaaccacga aattggactt cagagcggag cccatgctgg tgcggcgatg 1800 gtcggaggca gtgggagcta ttttcgatta gaaaatcgat agtattatag tattataaga 1860 gacgcgcaga aaacttactc ttaatcacag ccggagtact gggctttgag tgtggacaca 1920 tgttgctcaa ctccgattgc gatgtggaga tgttggtgga ggagttccgg tgcgagctgc 1980 tgtactttgg ccgggcggtg ggcgtctggc tgccactgtc gtagtgcctg gaggcggtcg 2040 attgacgcct ctcccgcatg ctggagcagt ctcctccgct ccgcttgccc gccgtactgg 2100 tgatgctgcc tatattatca tcggtctgag cggacaccga gtttctcttc tccagatggc 2160 gatgatgatg ctgctgctgc tgctgttgct gttgcatctg ctggtgttgc tgctgctgca 2220 ggtgctgctg ctgcatctgc tgatgttgct gtaagtgctg ctgcagttgc tgctggatgg 2280 gctgcatcat agttggagca ggggcatgcg agtggtgctc tacaatcgat tgctttttct 2340 ttttgctgtt ggagaatatc catagattag agtgtattta agaccaaaat ttaagaactt 2400 acggaggaag cgatggcgcc atcactgtag actgcaccga cacaaaggag ttatccatct 2460 ccacatgagt cgaggtcaca ctatccacgg acgtcatctc ggtaacttct atgacaaacg 2520 ggttgcaatg catgaacata tctacgaaat ccccctcctt agccactcac ctgtggtgct 2580 gggcatctct cgacgcaccg gtggagctga gagcctaaca atgtcatcgt tcagtatggg 2640 ctccagttcg ctaccgacgt tggagccacc tgtgcaggtc accccatcga tccatttgcg 2700 tgcctcgggt cccagcttgc ggattaaggc ctgcagctcg ttctccttct ccatcagcgc 2760 ctttcggaat cggcagtttg tgttctttac atctcgcaat cgttgctcca gttcgcacac 2820 cgaggaatcc cggcgtccgt ttttggacat gggtctcaac gtggccctaa cgcgtttgtc 2880 caccacgccc tggggattcc gcttcagctc caccaactgc aaaacgattc gcatgaatat 2940 taaccaaaga ttatactacg cggtcaacat ctaggaagga tcaactctac ggacagtaat 3000 ataggatagt taaagatatt ccaacagcaa ggaagtggga tttgcctaca accttgctgc 3060 tgctcttagt gggttctata tagttcaagt ttatagttag tctgtagtgt tatatagcat 3120 tttaagatct gttttcgagt acatgttgtt tctgtatcaa ggtgtatcaa cgctagacga 3180 aagatcagct cagctggcgg taaagtacga tcagttaaga agctctaacc acaactgatc 3240 ggcctattac cgccgacaaa caacattcat attacacgat tattatatgt aacatataac 3300 agctacaaaa actacaaaac ttccttacta ccagtcttac tttcggtacg aacaccaaac 3360 acaaagtggc tgtcgtacaa aaaatgataa aaaacgagag taagacaaaa actaaatcct 3420 ttcgatccga tagcaccagg gatatagccg ctccggccag acaagtgatg aacacgttat 3480 aaacggagaa accaatatgc ttggaatcgt tcagagccgg tatagaaaca tgtcgagttt 3540 cccaggccaa aaaggcgcca aaaacctatt gaaaaaaatt attgctttat tataatgata 3600 tcttacaaat taatgtttat tatatactca ccaacaacag tcccttgtag gcataaataa 3660 tgctaacgaa tatggtcatg tgctcagact ggcagtactc gttttcgggg atcaccaaga 3720 catcatcaat attctcgtga tgctgtagtt aataataatc attttagatt tttcacttca 3780 aatatgttct atcaatgcac tcaccaaggg ttccaactgt ttagtttcgc ggtaaaaggg 3840 atcggcaatc tgccaggtgg ttataatggc tatatcaatg gccaaaagca cgcccacaac 3900 cataaacaat tgatagtcct tgatcacctt cttattgagc ttcagatcgg tgaatatcga 3960 atgcacccgc cacgtcttcg agaacatggc tccaaaactg agactgaatc cagccatcaa 4020 gatccaggct cgagctgtgc agatataggg aaaagctgcc acactactta atgtggtatc 4080 gagacccagg aaaatgatgc tcaaataggt catcatacag cccacaatga tcagattgtt 4140 caaatgggga ctggacatct tgatgtatct ataaaaacat caatatttta ttaaacgaaa 4200 ttgtttaata tagcattgtt aagctcacct ttgattgcga tacttaatgt taaaggccag 4260 aaaaactgtg gcaataatca ctccaatgac cgaagcacta gccgatacaa tatatatggt 4320 tggattgacc tgactgtgct cgatgtagat caaagtgcga tccttgggag gagttttccc 4380 cacccatttg actggttttc ccaagcttaa atccaagtgt gacttctgtg agtggtattc 4440 cccgatcttt tccatttgtc ccagctgaaa ctgattgatc aggatgttgg ccttgcgctc 4500 gttgttgtag aaacgcacgg gtcccttgag aatgtaaaat atgttttaac tgcaaaaact 4560 ggattgttta tctatctacc gtcacaccct cgaaggatgt attacgtaga gcctcaagga 4620 agacactctc ccagtccttc acgcgataat caaaatgtgt tagcagatcc tctcgctttt 4680 cggccacata ctgaatggcc agggcagctg cccagatacc atcgtaggta tagccatgaa 4740 agcgggaata ttcagtgcct cgcagtctgt cgtactccac aagatactca tcagcagtct 4800 agtaaaatat gaaatttatt acaagaattt taatagactt tactggtact aacaatgcca 4860 gccactgtga tgtcaccact ggtggacaag ggcaaaagat ccactagaat ggcaccttcc 4920 aaggctgtag cgatctcctc cacactgcac tcgctgtcct gcgtgacatt ccaccaatcc 4980 gtggaatagg tagccatgat cagccattga taggctctgc catacatatc caatctggaa 5040 gggagtttat tgcaataatt ttaaattgag acttaagtta gtatatccaa ctcacttata 5100 agcctcacag aatgccttgc gtgcaaagtg ctcgttaaag ttgcccagaa tgatcctcac 5160 gtccttctcg cgcagtttct tcaatgattc agccacatcg ttgacgaagc tctgcgtttc 5220 caccacctcg acctccatgg catccaggtc agccaccatg tgattgtggg gcagcgaata 5280 gcgtggctca ttctggtaga cagtgcccac tctggtccaa ttgaactcct tcagcaaggc 5340

81 cagtcgcggc gcattaaagg cattctccga gggtaccacg cgaaagaaat tcggaaacgc 5400 atccttggtg aacatgggat gggtgtccgc gtagctgagc tgggtgaggt gccagtgctt 5460 gctggccttg gctatgggat cggtcacatg ggtgcacgca gcgccgaaga gcatcacttt 5520 attgggaccc gaatgcatca tatcgaagaa ggactttacg cccacagcag cattgcactg 5580 gaaaggaaac caaaattaca ttccagaata tatggaaata tgcataggta aaggtgtgat 5640 attacaatat gaaccaatga acattaaaaa aaatacctaa ttgaacttta aaaaccacaa 5700 gtccatcatc agagattcac ttaatgaaat cttcaagcta aaccctaact cacctgagtg 5760 tcgttccacc acatgtgcag cctgtagttg gccagtatct ttccatgctc attaacgtga 5820 cccaaggcga gctttacact gggcataacg ccccgaccgg tgtaggagtt ttccacgcca 5880 tccccgtacg ggaagaatcc cgctatgtag acgtccgatc tcttggctgt cctgccacag 5940 gcggtgctcc aaaggagcag gaacagcagg ctggcgaatg gaaaccaact tggccggaac 6000 atgttgaccg cgtgggctgt aaaacgattc taaatgtgaa tagcgcatat cgaggacgtg 6060 aacttggagc caagttgtgg gtggtgaatg gcagtggttg gtttcgggtg agccaaggct 6120 gccgaggcaa ggctgcgccc agtgggtgtg tattattttc tacgttctac ctgtgtttgc 6180 tggcactcgc atgcaatttt acaggacagg tggagcaagg ctaaggccag tccaggccag 6240 caaaattgct tcaaattgct gcagcaatgc tggcacgttt agtaattata aagcaattta 6300 atgatctaaa ggattcgtgc attatttagt atgctcgtta acgcgaagga gtatcttcca 6360 ggtgttgcat cctcttaaat cttatgtgta catgttttta ggaacctacc agcttgctta 6420 gtcccagaac tggcttttat ttcactaccg atgccatttg aaacacttat tttacatcaa 6480 atctcagcca acgaagaact tttgcagtgc gagggtccga aaaattatgt atccccctga 6540 cttgacattt gtctgacagg aggaattcga ggcaggaagt gcgcatgtcc ttaaaccgaa 6600 agctgtcact gctccgcctt ggcctaggct ttccaacccc cgtaattacc ataaacccac 6660 tgcgcttgta aacatcctgc aacaggtggt cccatcagct ggtactccgg caattgttgt 6720 gcccgttgcc atggactact ggggtcgaaa aacgaagtag ataactgctc ggaaaattac 6780 caaattgaaa attgtgagta accataatgg aggactatgc gcccagccgc tataaaatgc 6840 ttgagaaaat cggcgaaggc gtccatggct gcgtgtttaa ggccatcgat ctgcagcgca 6900 acaaggaggt ggccatcaag aaggtggccc ttaagaacaa gttcggaaac atagccctaa 6960 atactttgag ggaaatcaag accctgcagc tttgcaagtc tgaatatgta ggtataccat 7020 atatctattt tccatttgtt aattatgtaa ctaattgtag attctggaca tcattgatat 7080 atatcctgac ctaactggtc tctccttggt gctggaatac cagccggaca ctctgtacaa 7140 ccgcctcaag agcgaggtta atcccctgag ccgccagcag gtgcgtaagt ttgcacacca 7200 aatgttcaag gggattgcat atctgcatga agcgggtctc atgcaccggg atattaaacc 7260 cgccaatctg cttatcagcg atacagatat gcttaagatt gccgatttcg gactggcccg 7320 tctgtacttc cctgaagacg agtcgcgcct ttattcgcct caggtctcaa cccggtggta 7380 tcgagcgcca gagattctat ttggcagcca gaagtatgga accggagtgg atatgtgggc 7440 ggcaggttag ccatgactct ttgatgggtt tacatatatc cttatggctg acattattgc 7500 tat 7503

<210> 59 <211> 3971 <212> DNA <213> Drosophila

<400> 59 aaaagttctt cgttggctga gatttgatgt aaaataagtg tttcaaatgg catcggtagt 60 gaaataaaag ccagttctgg gactaagcaa gctgcccacg cggtcaacat gttccggcca 120 agttggtttc cattcgccag cctgctgttc ctgctccttt ggagcaccgc ctgtggcagg 180 acagccaaga gatcggacgt ctacatagcg ggattcttcc cgtacgggga tggcgtggaa 240 aactcctaca ccggtcgggg cgttatgccc agtgtaaagc tcgccttggg tcacgttaat 300 gagcatggaa agatactggc caactacagg ctgcacatgt ggtggaacga cactcagtgc 360 aatgctgctg tgggcgtaaa gtccttcttc gatatgatgc attcgggtcc caataaagtg 420 atgctcttcg gcgctgcgtg cacccatgtg accgatccca tagccaaggc cagcaagcac 480 tggcacctca cccagctcag ctacgcggac acccatccca tgttcaccaa ggatgcgttt 540 ccgaatttct ttcgcgtggt accctcggag aatgccttta atgcgccgcg actggccttg 600 ctgaaggagt tcaattggac cagagtgggc actgtctacc agaatgagcc acgctattcg 660 ctgccccaca atcacatggt ggctgacctg gatgccatgg aggtcgaggt ggtggaaacg 720 cagagcttcg tcaacgatgt ggctgaatca ttgaagaaac tgcgcgagaa ggacgtgagg 780 atcattctgg gcaactttaa cgagcacttt gcacgcaagg cattctgtga ggcttataaa 840

82 ttggatatgt atggcagagc ctatcaatgg ctgatcatgg ctacctattc cacggattgg 900 tggaatgtca cgcaggacag cgagtgcagt gtggaggaga tcgctacagc cttggaaggt 960 gccattctag tggatctttt gcccttgtcc accagtggtg acatcacagt ggctggcatt 1020 actgctgatg agtatcttgt ggagtacgac agactgcgag gcactgaata ttcccgcttt 1080 catggctata cctacgatgg tatctgggca gctgccctgg ccattcagta tgtggccgaa 1140 aagcgagagg atctgctaac acattttgat tatcgcgtga aggactggga gagtgtcttc 1200 cttgaggctc tacgtaatac atccttcgag ggtgtgacgg gacccgtgcg tttctacaac 1260 aacgagcgca aggccaacat cctgatcaat cagtttcagc tgggacaaat ggaaaagatc 1320 ggggaatacc actcacagaa gtcacacttg gatttaagct tgggaaaacc agtcaaatgg 1380 gtggggaaaa ctcctcccaa ggatcgcact ttgatctaca tcgagcacag tcaggtcaat 1440 ccaaccatat atattgtatc ggctagtgct tcggtcattg gagtgattat tgccacagtt 1500 tttctggcct ttaacattaa gtatcgcaat caaagataca tcaagatgtc cagtccccat 1560 ttgaacaatc tgatcattgt gggctgtatg atgacctatt tgagcatcat tttcctgggt 1620 ctcgatacca cattaagtag tgtggcagct tttccctata tctgcacagc tcgagcctgg 1680 atcttgatgg ctggattcag tctcagtttt ggagccatgt tctcgaagac gtggcgggtg 1740 cattcgatat tcaccgatct gaagctcaat aagaaggtga tcaaggacta tcaattgttt 1800 atggttgtgg gcgtgctttt ggccattgat atagccatta taaccacctg gcagattgcc 1860 gatccctttt accgcgaaac taaacagttg gaacccttgc atcacgagaa tattgatgat 1920 gtcttggtga tccccgaaaa cgagtactgc cagtctgagc acatgaccat attcgttagc 1980 attatttatg cctacaaggg actgttgttg gtttttggcg cctttttggc ctgggaaact 2040 cgacatgttt ctataccggc tctgaacgat tccaagcata ttggtttctc cgtttataac 2100 gtgttcatca cttgtctggc cggagcggct atatccctgg tgctatcgga tcgaaaggat 2160 ttagtttttg tcttactctc gttttttatc attttttgta cgacagccac tttgtgtttg 2220 gtgttcgtac cgaaattggt ggagctgaag cggaatcccc agggcgtggt ggacaaacgc 2280 gttagggcca cgttgagacc catgtccaaa aacggacgcc gggattcctc ggtgtgcgaa 2340 ctggagcaac gattgcgaga tgtaaagaac acaaactgcc gattccgaaa ggcgctgatg 2400 gagaaggaga acgagctgca ggccttaatc cgcaagctgg gacccgaggc acgcaaatgg 2460 atcgatgggg tgacctgcac aggtggctcc aacgtcggta gcgaactgga gcccatactg 2520 aacgatgaca ttgttaggct ctcagctcca ccggtgcgtc gagagatgcc cagcaccaca 2580 gaagttaccg agatgacgtc cgtggatagt gtgacctcga ctcatgtgga gatggataac 2640 tcctttgtgt cggtgcagtc tacagtgatg gcgccatcgc ttcctcccaa aaagaaaaag 2700 caatcgattg tagagcacca ctcgcatgcc cctgctccaa ctatgatgca gcccatccag 2760 cagcaactgc agcagcactt acagcaacat cagcagatgc agcagcagca cctgcagcag 2820 cagcaacacc agcagatgca acagcaacag cagcagcagc agcatcatca tcgccatctg 2880 gagaagagaa actcggtgtc cgctcagacc gatgataata taggcagcat caccagtacg 2940 gcgggcaagc ggagcggagg agactgctcc agcatgcggg agaggcgtca atcgaccgcc 3000 tccaggcact acgacagtgg cagccagacg cccaccgccc ggccaaagta cagcagctcg 3060 caccggaact cctccaccaa catctccaca tcgcaatcgg agttgagcaa catgtgtcca 3120 cactcaaagc ccagtactcc ggctgtgatt aagactccca ctgcctccga ccatcgccgc 3180 accagcatgg gctccgctct gaagtccaat ttcgtggttt cacagagtga cctctgggac 3240 acgcacacgc tgtcgcacgc caagcagcgc cagtcgccgc ggaactacgc cagtccgcag 3300 cgctgtgcgg aacatcatgg cggccacggg atgacctatg acccgaacac cacctcgccc 3360 atccagcggt ccgtctccga gaagaaccgc aacaaacatc ggccaaaacc gcaaaagggc 3420 accgtttgcc agagcgagac ggacagcgaa cgggaacgag atccgccgcc caacagtcag 3480 ccgtgcgtcc agccgcgtaa ggtcagccgg agctctaaca tccagcacgc cgcccaccac 3540 cacagttcgc ccaatgtggc gcccgataag cagcggagca ggcagcgcgg caagcaggat 3600 agcagcatct acggcgccag cagcgagacg gaactgctcg agggcgagac ggcaattttg 3660 cccatcttcc ggaaactcct caccgagaag agtcccaact atcggggccg cagtgccgtg 3720 ggccagagct gtccgaatat atccatcaaa tgcgatatcg tcgagtactt gtaggcggcg 3780 cgagtcatat gcattatgcc gtagttaaac tcctattgtt agatccagtt gcagtgtaaa 3840 gattatcttt gttttctttg gagttacgca tctacataca taccctgtga agcaggacac 3900 acaccattta gtgaactagt agcaatgaca tgagatagtt gggaaataaa ttacaattta 3960 aaataatcat a 3971

<210> 60 <211> 1221 <212> PRT <213> Drosophila

<400> 60

83 Met Phe Arg Pro Ser Trp Phe Pro Phe Ala Ser Leu Leu Phe Leu Leu

1 5 10 15

Leu Trp Ser Thr Ala Cys Gly Arg Thr Ala Lys Arg Ser Asp Val Tyr

20 25 30

He Ala Gly Phe Phe Pro Tyr Gly Asp Gly Val Glu Asn Ser Tyr Thr

35 40 45

Gly Arg Gly Val Met Pro Ser Val Lys Leu Ala Leu Gly His Val Asn

50 55 60

Glu His Gly Lys He Leu Ala Asn Tyr Arg Leu His Met Trp Trp Asn 65 70 75 80

Asp Thr Gin Cys Asn Ala Ala Val Gly Val Lys Ser Phe Phe Asp Met

85 90 95

Met His Ser Gly Pro Asn Lys Val Met Leu Phe Gly Ala Ala Cys Thr

100 105 110

His Val Thr Asp Pro He Ala Lys Ala Ser Lys His Trp His Leu Thr

115 120 125

Gin Leu Ser Tyr Ala Asp Thr His Pro Met Phe Thr Lys Asp Ala Phe

130 135 140

Pro Asn Phe Phe Arg Val Val Pro Ser Glu Asn Ala Phe Asn Ala Pro 145 150 155 160

Arg Leu Ala Leu Leu Lys Glu Phe Asn Trp Thr Arg Val Gly Thr Val

165 170 175

Tyr Gin Asn Glu Pro Arg Tyr Ser Leu Pro His Asn His Met Val Ala

180 185 190

Asp Leu Asp Ala Met Glu Val Glu Val Val Glu Thr Gin Ser Phe Val

195 200 205

Asn Asp Val Ala Glu Ser Leu Lys Lys Leu Arg Glu Lys Asp Val Arg

210 215 220

He He Leu Gly Asn Phe Asn Glu His Phe Ala Arg Lys Ala Phe Cys 225 230 235 240

Glu Ala Tyr Lys Leu Asp Met Tyr Gly Arg Ala Tyr Gin Trp Leu He

245 250 255

Met Ala Thr Tyr Ser Thr Asp Trp Trp Asn Val Thr Gin Asp Ser Glu

260 265 270

Cys Ser Val Glu Glu He Ala Thr Ala Leu Glu Gly Ala He Leu Val

275 280 285

Asp Leu Leu Pro Leu Ser Thr Ser Gly Asp He Thr Val Ala Gly He

290 295 300

Thr Ala Asp Glu Tyr Leu Val Glu Tyr Asp Arg Leu Arg Gly Thr Glu 305 310 315 320

Tyr Ser Arg Phe His Gly Tyr Thr Tyr Asp Gly He Trp Ala Ala Ala

325 330 335

Leu Ala He Gin Tyr Val Ala Glu Lys Arg Glu Asp Leu Leu Thr His

340 345 350

Phe Asp Tyr Arg Val Lys Asp Trp Glu Ser Val Phe Leu Glu Ala Leu

355 360 365

Arg Asn Thr Ser Phe Glu Gly Val Thr Gly Pro Val Arg Phe Tyr Asn

370 375 380

Asn Glu Arg Lys Ala Asn He Leu He Asn Gin Phe Gin Leu Gly Gin 385 390 395 400

Met Glu Lys He Gly Glu Tyr His Ser Gin Lys Ser His Leu Asp Leu

405 410 415

Ser Leu Gly Lys Pro Val Lys Trp Val Gly Lys Thr Pro Pro Lys Asp

420 425 430

Arg Thr Leu He Tyr He Glu His Ser Gin Val Asn Pro Thr He Tyr

435 440 445

He Val Ser Ala Ser Ala Ser Val He Gly Val He He Ala Thr Val

450 455 460

Phe Leu Ala Phe Asn He Lys Tyr Arg Asn Gin Arg Tyr He Lys Met 465 470 475 480

84 Ser Ser Pro His Leu Asn Asn Leu He He Val Gly Cys Met Met Thr

485 490 495

Tyr Leu Ser He He Phe Leu Gly Leu Asp Thr Thr Leu Ser Ser Val

500 505 510

Ala Ala Phe Pro Tyr He Cys Thr Ala Arg Ala Trp He Leu Met Ala

515 520 525

Gly Phe Ser Leu Ser Phe Gly Ala Met Phe Ser Lys Thr Trp Arg Val

530 535 540

His Ser He Phe Thr Asp Leu Lys Leu Asn Lys Lys Val He Lys Asp 545 550 555 560

Tyr Gin Leu Phe Met Val Val Gly Val Leu Leu Ala He Asp He Ala

565 570 575

He He Thr Thr Trp Gin He Ala Asp Pro Phe Tyr Arg Glu Thr Lys

580 585 590

Gin Leu Glu Pro Leu His His Glu Asn He Asp Asp Val Leu Val He

595 600 605

Pro Glu Asn Glu Tyr Cys Gin Ser Glu His Met Thr He Phe Val Ser

610 615 620

He He Tyr Ala Tyr Lys Gly Leu Leu Leu Val Phe Gly Ala Phe Leu 625 630 635 640

Ala Trp Glu Thr Arg His Val Ser He Pro Ala Leu Asn Asp Ser Lys

645 650 655

His He Gly Phe Ser Val Tyr Asn Val Phe He Thr Cys Leu Ala Gly

660 665 670

Ala Ala He Ser Leu Val Leu Ser Asp Arg Lys Asp Leu Val Phe Val

675 680 685

Leu Leu Ser Phe Phe He He Phe Cys Thr Thr Ala Thr Leu Cys Leu

690 695 700

Val Phe Val Pro Lys Leu Val Glu Leu Lys Arg Asn Pro Gin Gly Val 705 710 715 720

Val Asp Lys Arg Val Arg Ala Thr Leu Arg Pro Met Ser Lys Asn Gly

725 730 735

Arg Arg Asp Ser Ser Val Cys Glu Leu Glu Gin Arg Leu Arg Asp Val

740 745 750

Lys Asn Thr Asn Cys Arg Phe Arg Lys Ala Leu Met Glu Lys Glu Asn

755 760 765

Glu Leu Gin Ala Leu He Arg Lys Leu Gly Pro Glu Ala Arg Lys Trp

770 775 780

He Asp Gly Val Thr Cys Thr Gly Gly Ser Asn Val Gly Ser Glu Leu 785 790 795 800

Glu Pro He Leu Asn Asp Asp He Val Arg Leu Ser Ala Pro Pro Val

805 810 815

Arg Arg Glu Met Pro Ser Thr Thr Glu Val Thr Glu Met Thr Ser Val

820 825 830

Asp Ser Val Thr Ser Thr His Val Glu Met Asp Asn Ser Phe Val Ser

835 840 845

Val Gin Ser Thr Val Met Ala Pro Ser Leu Pro Pro Lys Lys Lys Lys

850 855 860

Gin Ser He Val Glu His His Ser His Ala Pro Ala Pro Thr Met Met 865 870 875 880

Gin Pro He Gin Gin Gin Leu Gin Gin His Leu Gin Gin H s Gin Gin

885 890 895

Met Gin Gin Gin His Leu Gin Gin Gin Gin His Gin Gin Met Gin Gin

900 905 910

Gin Gin Gin Gin Gin Gin His His His Arg His Leu Glu Lys Arg Asn

915 920 925

Ser Val Ser Ala Gin Thr Asp Asp Asn He Gly Ser He Thr Ser Thr

930 935 940

Ala Gly Lys Arg Ser Gly Gly Asp Cys Ser Ser Met Arg Glu Arg Arg 945 950 955 960

85 Gin Ser Thr Ala Ser Arg His Tyr Asp Ser Gly Ser Gin Thr Pro Thr

965 970 975

Ala Arg Pro Lys Tyr Ser Ser Ser His Arg Asn Ser Ser Thr Asn He

980 985 990

Ser Thr Ser Gin Ser Glu Leu Ser Asn Met Cys Pro His Ser Lys Pro

995 1000 1005

Ser Thr Pro Ala Val He Lys Thr Pro Thr Ala Ser Asp His Arg Arg

1010 1015 1020

Thr Ser Met Gly Ser Ala Leu Lys Ser Asn Phe Val Val Ser Gin Ser 1025 1030 1035 1040

Asp Leu Trp Asp Thr His Thr Leu Ser His Ala Lys Gin Arg Gin Ser

1045 1050 1055

Pro Arg Asn Tyr Ala Ser Pro Gin Arg Cys Ala Glu His His Gly Gly

1060 1065 1070

His Gly Met Thr Tyr Asp Pro Asn Thr Thr Ser Pro He Gin Arg Ser

1075 1080 1085

Val Ser Glu Lys Asn Arg Asn Lys His Arg Pro Lys Pro Gin Lys Gly

1090 1095 1100

Thr Val Cys Gin Ser Glu Thr Asp Ser Glu Arg Glu Arg Asp Pro Pro 1105 1110 1115 1120

Pro Asn Ser Gin Pro Cys Val Gin Pro Arg Lys Val Ser Arg Ser Ser

1125 1130 1135

Asn He Gin His Ala Ala His His His Ser Ser Pro Asn Val Ala Pro

1140 1145 1150

Asp Lys Gin Arg Ser Arg Gin Arg Gly Lys Gin Asp Ser Ser He Tyr

1155 1160 1165

Gly Ala Ser Ser Glu Thr Glu Leu Leu Glu Gly Glu Thr Ala He Leu

1170 1175 1180

Pro He Phe Arg Lys Leu Leu Thr Glu Lys Ser Pro Asn Tyr Arg Gly 1185 1190 1195 1200

Arg Ser Ala Val Gly Gin Ser Cys Pro Asn He Ser He Lys Cys Asp

1205 1210 1215

He Val Glu Tyr Leu 1220

<210> 61 <211> 18996 <212> DNA <213> Drosophila

<400> 61 gttccttaaa cgtgatcaaa aatataacta gagctactac taagcagcga gcacagcgtg 60 cgatatatca acaagtccag ctggcaacat gttgccgcgc ctgtggtgag ttgtgcctct 120 atgtcctttg gcagcatgtt gcggtcgctt ggcgccggct ggtggtcaca aaaagcgccg 180 acgcttgccg tcagtgcttc gcgaagattg cgaggcgcga cacacatcgc ggaacccgaa 240 ctccatacgg ctgtgccgac actcaatccc gacctaagcc caattttttg ttgcgtgaag 300 ttgacgaagt gtgttgtact gctgcaagtg caagtccccg attgctagtg ctattccggg 360 atcacaaacg agcatccttc ttcggcctca cgattgacgc cttctaccac tacctgcgcc 420 aggcgctgcc gctggccaag gaggctgcga tccacctgaa tgccagcaac gagatctccg 480 ctgtcggtga cggggtcacc atcacaggga cacccggtga tcttctcaac tacagcgggc 540 tggaattgga tctcggactg gatttggatc ttaatctgga catggaccta gccactactc 600 ccagcagcag caccttggcg ccagctgtaa ccgtcaggac accggggaac aggagcgtgg 660 tgagggtcag tgccgatgtg cccatctggg tggtgccgtg ctattcggcc atccttctgt 720 gcgccgtggt cgggaacctg ctggtggtgc taacgctcgt ccagaatcgt cgcatgcgca 780 ccatcacgaa cgtttttctg ctcaacctgg ccatctcgga catcctgctc ggcgtattct 840 gcatgccggt gaccctggtc ggcactctgc taaggcattt catattcggc gagctgctct 900 gcaagctcat ccagtttgct cagggtgagt ggtggaagcc agtaggccag ttcatttatg 960 tcttgtccgt gtccaaatta aaaggttatc ccaaacttcc aactgtgaat tccgcattta 1020 ttagtcccta tccccgtgac cgagccccat aatcgcttgt caaatggcca cgaaccagca 1080

86 cgacctcgag cggattcgcc agcagatcgt gttggccaac attcaggagc tgataaagaa 1140 gatgacacgt cgctgcttcg acgtatgtat cgctatgccg gaaatggagt tgcgctccac 1200 ggagcgcgac tgcctggcca actgtatgga tcgattcatg gactcggttc aggtggtgtc 1260 gagccagtac ttccgtcgcc ggcgtcgcca tcagcaaatt cgtttgtccc gttcgaccgc 1320 ctcctccgca tcaccaccag catccgcatc cgcatccatg cccaaatccg cagcagcaaa 1380 tgaatctgaa tccgcatcta gggcctccaa tgacgaaaag gtcaaataat ggttaagtct 1440 agacagatag ccacgtgtgg agtttattcc aagtcgaaaa cgaaggctgt tccgtcgtag 1500 ccccagatcc ccagtgtact tgggtgatgg ccacttgtcc acattggtca tcatcccaaa 1560 gctttcgagg atgatttcat acttcgagac ctttgggaag ggcaagaagg ggtcgtctag 1620 ctggaaatga aagtggattt tctgcaggcg tggccatcga tgatttcttg ctattggttc 1680 ttaacaaaat cctagtagag tcttaagtaa atgacgattg gcagaaaata aagatgtcgt 1740 tcagtgtaca ttcactatgc tttgagattc tctttaaagt cacccttttg aaatcactta 1800 gctaagctta atattgtata atatacaaag tagtgtagtg gggagaagat aagttttaaa 1860 tgaccatact gtatatttta gattgtgcgc ttgtgcacat cacttttcca cttaggaaaa 1920 ctgagtctgc catcgatttt acgcacaatt tccgcgctta tttatggcct aaatcatatt 1980 tcgttggcaa gaacgcacta tatctcgtct cccaatctgc atccgcctga gaatggccgt 2040 attttatgat ggccgcccgc atttgcgtaa cgacagtcag ggtttccccg accagcgagc 2100 accgggtttt gggttcctca agggttcaaa agattaaata ggcccacgca cacgacacac 2160 acacgcacac acacgcactc gcacactgta aatatgcggg ggaagctctt taaaaccatt 2220 tcaactcaat gactgtgccc aaaactcatg tttggtcctt gaaaagtcca gtcagatggg 2280 taaacattct caccaggcat taatttgtgt ctccagctca gataagggtt ggtgatgtgg 2340 gtggcgatat tcatcagctg agcccggttc agccatctgt gatatggttc gccttcggcg 2400 tgattccatg tcccgtcggc ggcagtggaa cagaatgaag cagaaatgtg gccctgacac 2460 ctgtcacaaa tgctaatcgg catttcggtt tcaaggagcc gagcggcatt aatttgctta 2520 tttaatcaaa gtgcatgcca tcggacattc taattatttt cataacggta aggagaggtc 2580 ctcaacctgt ttcacctcct aggactcctt ggaggcgcat ccaaacggat gatgaagctc 2640 agtccaggcc agtcatcctc cattcccgca agattaatcc aggctgatcc ccatttccaa 2700 tgcaaattgc tcgcctgccg ggagctctgc ttctgctcag cattctggtc aatttccata 2760 tgtacgcagt gtcgatctgg gagcctactc acccttctca cccagctcct gttaccctgt 2820 tccttgctcc tttggcgttg tagcactcaa gtcgcagcct aagcagtctg gaattgcttt 2880 taaccgtggc aatattgcga aaatcactct gctatgcagc gtcacgtcgc gattttcttg 2940 tagtgttccg ttccgaagcc cctttccccc atcagctcca tcagctccgc tagctgctcc 3000 acatccttta cgtcccctcg ccgatccttc tgacaccctt ccttgcattt tcatgacttg 3060 tttcctgttt cctgcgtttc cgtttcagac gtgctggtga tgttgtttgt cttgctgcaa 3120 gtttgttttc ggtactgccg gaaccgctgt tctctcctgg cctccaacac cacccccccc 3180 cctatccact gcccccggca tcctgacgta tcctggcgta ccctggcata tccatcttgg 3240 ccgcccccgc actaacttat taacaacata ataacaatgg ctggcaaaca agttgagcgc 3300 tcaggcacac acatgccaat ttgttcagca agcactcggc gctgtctcga gccccagaaa 3360 ggcccagaaa aggagctggc attcagtttc caaggattcc gcgcccccat cctcatccgc 3420 atccgcatcc ttgttcgcat tcccattcct ttccatctgt tgcacggggc gtcgactcgt 3480 gggtcgtaaa tctgaaaatg tcatccctgg ctgggctgag gcaccaattt atggccatca 3540 tcacgtcaag gtgcagcgat gtcctgacac gtccttcctg gctccctgtc ccacctggct 3600 ccttccggag tgggcgtgaa cgcgcccctg gatttatgat cgtaattatg catttgtggc 3660 cagtggcatt tgcattggac tcctgccagt ggcaaccaat cgccacccac tgccattcga 3720 tttcatcatc ttgcttgcaa gagtaatgtt ggcattgtcc attacttatg taaatcgaaa 3780 ccgaaggata agctcctgta agtccatatt ggttatagtt tctgcatatt cgatctacca 3840 agaatttcaa cgaaattcac aagcgaggca gcaataacaa gctcaaagtt agtcggatta 3900 tggggagcta ctaaaaatac atagttgttg acttttggct cagaattaga ggtaataaaa 3960 cacaaaccga tggtcttttt ttatggtcct tttcttttcg caagaaattc ctcctcgaaa 4020 acgaacatct tagcaactaa tattagcaac tttgtatgtt gcccatacca aaaagagtgt 4080 gaaaggaatg ttttctgttt gatgaacact ttaaggctag gacataatct cagataaact 4140 gttgtctaat taacttaatt tgatatccaa ttaaagtaac tatgtgtgct ggtaagacaa 4200 agaaaaggtt tctttgtggc gcttgaaaag gacatttgtg tgcggaaaag ggtcaaattg 4260 acatccttag accaaagttt atggctttgg gctttagaat tttctctatt ccactgctcg 4320 acctggttgc actttttgta ccccaggcgg gacggccttg aaccctgacc tgtggatggg 4380 ccacccattg ggcgcgtcca actcgtccaa gtcgctgaca gctcggcaaa ttaatgatta 4440 attgaatttt ccttggctct gttttgggtt tttttttttt tgttgtccat tctattattt 4500 cttgttttct tggcaacaca aatacaaatc agcgccacac agacgtaatc attaattagg 4560 cgcgcaggga gctaagtgtc tcaagaaatg tgggcgcagt gcaattccag ctagtttttc 4620 aagggccaaa ggcactcgta atgagcaaat ttatgcacaa acacacagtt tctacagttt 4680

87 ctgatggagc ttggcaaaca ttaaggggcc aaatggcata agtagaaaaa cgaattgaaa 4740 taagaactaa ccacgatgct ctcgtttttc ttatttccta tccccccatg tgggcggtac 4800 atgttattga cgcccaaagt gccgccccca tagacccatg ccaccgtgcc acgcgcccac 4860 tctttttctt ttgctggctc caaagtttga acggcatctg cagagaaacg ggcttatttg 4920 actgagaagg aggtaggagg tcggcgaagg acgcatttat ttgaacttat gtacacaagt 4980 gcacatatat acatatatat atatacatac atactgcgct gtgtatgcct gccatattca 5040 tgttcatgtt gttttcgcct tttaatgaga gttaactgag cgggggaact ggaaactccg 5100 cggccaacga tgaatatgaa tgcgccactc aacttaatcc cactcaatca ttatgtggca 5160 atccgcccag ttctttttga ccatgggtct gcaattgtcc tctcggctcg tactcgtaca 5220 caagccccaa cattatttgc accgaacgta tctctgtacc gatctgaatt cgtattgcat 5280 gtcgaactcg acactttatg gtgctccgaa attgttttgt aagcgaaata atggcaagtt 5340 atgacaccca gtgttacaca caattgacat ggttattgat tttcaattat ataaatattt 5400 gcaactaagg aaaaaagcct ctgctgccac tgctgccact gatgtcctgt ggaaaaagca 5460 tttaaatacc gtgttcatcg gcaatctgtg tgcgcttctg tgtattttca atttgcatac 5520 acctgcccat gaagaggcga aagtgatgtg ttaaatgaaa atatgctcct aataaacgtt 5580 tttcatcggt ttcccgtata attgttttct ggctttcaac actacactgc acgaaattta 5640 aggctaacgc gcgagtgggg agcgtgtggc atgaaatcaa tttcattcgt tggttttaaa 5700 gccccgtgtc ccattgattt cgaggcaaaa gcttatattt gtcaagatca taatcaaagc 5760 tgtcggccat taaataaaat gctcaacgag agaaaagaaa cccattaaaa actgagcgaa 5820 ttaaagcgat ataaagcacc attttttgcg tgtgagtatt atttgcgtgg cgaaatgaaa 5880 tatactcctg agctgaatta atgagacccg gtaggcgggt tgaagtgggt gggctttgcg 5940 gacaggcatc ttaagggcgc aaggacatcg ggaacatgga acacggaaca cggaacacgg 6000 agcatggagc atgggcacaa agggaataca aatgaaaggt gatttttcag ctccctttgg 6060 ccttttgagg atttccatgg ggaaaccaca aagtgcggtt gacagggcct aatgtgaaat 6120 taacatggct tatatgcaac gcatactgcc ctgttgcatt catgtcagcc acacacacac 6180 acacacacat ccatgcaccc aaacaccgac agctcaaccg tccatctttg tgtagcgggt 6240 caagttgcca tcaagaacac ggttgtgcca ctgcctctgt tcatcctgtt taacagcccg 6300 gtattggatc ccgaatacca gccaccaccc tccgctccct acaacttgcc gcaaatttcc 6360 ttggacccaa tttattttgc aatttatcgc tggataaaaa gtgactgcga aaagcatttc 6420 aaagcggagg cgcaggacat tgaaaaaaca gtgccatgac aacaattacg gcgtgtttaa 6480 gtagcccgtc tgggtgaaag tcacgccgtg aactgccact ttctcccctt cgttggatgg 6540 cataaaagat agattgttta tagttggtat caaaaggaaa aaggcctggc caatgtcgca 6600 gattgaattg agtgctctgg agggaatcgg ggtcaccaaa tgctggcctc agagtccaga 6660 acgccagctc taagacttgt attattatgg tattaaatgg tcagggacac cagagtacaa 6720 ctttaaagta tcttggtata aagtaaagta tgcagtttta atcctaaact tggctcaaat 6780 gaccttatat tccaccattt ttaagtaaca gtccagtaga tttcaatgca tcacaattag 6840 aaatgaattc agccctgaag gctgaaaaat aaacccaatt aataatttaa agcttcggct 6900 gaacgattag catgcattat taacactcac aaatatatgc cataatatgt acttttatgt 6960 agagcactct caaattgtgt cacattcagc acattccttt cagttcgttt aattaaagtg 7020 tccaataaat taacgctcga caagaaggac aaacttaaat gcacttcaaa tggcgcagaa 7080 cccatcaaga ctttccatca atttgcaaaa gtgttggcca aaagtgaggc tccccacctg 7140 ggaactttgt ttccgtgaac tttgcaccgg cacgcggtga acgcgaaatg cattattcac 7200 ttttatgtct ttttcctcaa ctactgtccg ggacaaaaaa atcagtttgc aactgaagaa 7260 tcttacctcg actcgaactc caattgcgat gtccttgttg cccagctctc agctccttga 7320 tgatgcagcg cagcggcagt tgggctctcc gtaaatcgag cgacataaag cggtcaccca 7380 acattggcca ttcgatggga gtgtgacaaa gctcccagct aaacttcccc ggccatgtca 7440 tgcatgcgaa atggagttct cgagaagcag ctagtgaatc tttaatggat tcatcgattg 7500 cgaagcgaag gaagctgcaa aactttcggt ttttaagcca cgctcggttt ggtagttgga 7560 cactcgataa atttacccaa tcaccagaaa aatatgcaac agcttttggg cttcattcta 7620 ctctagtttt ccaattaaaa tgcaaagttc tagagtttcc aaaactcaat gctcctggac 7680 ccccatcctc gccggcgtcg tcatccttgg gaatggagat ctcactcgat ttggccatag 7740 agtgtgtagg acattttaat ttgttgtgtt ttacaatttg cccccataca aattcatgtc 7800 gattgaggct ttttcgcctg agtccgctca gtttatggca cttttataac tcacatgtat 7860 atatgtatat atgtatgtac agacaggcga ggacccccgg ggcggtaaaa agttgctctt 7920 ttttttcgat ggccttaact tggcgtatca atatgtgggg gggaaaacaa tgggaagcaa 7980 ttttttcaaa taatttcaca ggcgaaatca aaaggaagca gcccgggaag aacaagaacg 8040 cgcggcacat cgaccatctg atacctcttg tctatgctgg tgcggtgtcc attgtgggcg 8100 ccacaagtgg agggtagtga tctgttgata ccatcgacat tcatccgaga aaaaagcgta 8160 tccttgtgcc ttttcaatct ggccatcttg ccatccggcc atccaagcat cggctgccat 8220 cgagcgtcga aaaggccaaa cttttgcaca accgtttttt attgttgact caaatttgga 8280 attattttta tttgagcacc gtggagggac acacgcactg agtccataaa aatccacttt 8340 cagttatgtg gcagtgggtg taagtggaaa tgccgaaaga tggacttatt gtcattgagt 8400 atcatcgcat cgaatggggc gctaaatcaa aaacaacgac cagagggcaa tccggaattg 8460 gattggtttc gaaatctgga attcgcggtg gggggaaatt gaaaatgggc catattttgg 8520 caatcgattt gcatgcgccg cttaaagtca tttccaattc gataatcata atttatgaag 8580 ctgttttgta ttgcaatttt cgcatataaa ttacattaaa tatttacgtc agccgtgaaa 8640 aatacataaa tagtgcgtct ctggtgtgtc cgccgattcc gcgcgagtcc tttgtatccg 8700 catatcctgt tcaaacaata ctgcgctaga gtcgaaatcc aaatatttgc gcagcaaatg 8760 aaaagcattt aaatccggtc gcagaggtta accgtagtag tttttaagcc gcctggctgc 8820 cgcaaccggc aaacttttcg atccactctc gcgactagcg agcaattagc tgcggtcgca 8880 tttcattgtg ctacccgcta tttgcactaa actttacact cattaaacag gcgagaaatt 8940 attgcagcga agtgtccggg attaaagtgt tgcatcccca tcccgctgcc agtcggatga 9000 tgatgaggca tgatgggttt ctgccaggtg gtcgcacttt taattggtat tcaactttct 9060 cctttgaccc tcacaactcg aaacatgctc gtaatttacc aaccaaaata agcgagtttc 9120 ccagttccgt tccaacttcc ttggtcacct caaaagctga aggcgagaag cctgttcgct 9180 aagctaagcc gcactcaaag gttggctctg tgtttgcctt acctttgcag ttgagatgaa 9240 gataaacaga aataaatgaa atgttacatt tgtgtacctt gaaaatattc agaagccatg 9300 tttataaatg aaattataca tttatactat attttaatgc agtgcctggg aaaactctaa 9360 gacattggtg ttgcattaaa aataaagtgc ttaaaagtat gcaacacaga attgatagta 9420 ctgcattagc atgttgattc atctgaatat tgagttacat accccacatg ttgtacttat 9480 cagataatta tttgatttac atgcttaaat catatcagtg ctagcttacc cagaagccct 9540 aaattacttc tatcccaaga cattctctca gtgtacatgc ggtgggtatt cccaaaagtt 9600 taggaaaatt gcccgtggca tttggcttgc cagaaacgga tgcctgtcga agtgcagcta 9660 gttcttttgg gcaaaggcca gttatacttt tgcggttgtt agcttaattt aatgtaactt 9720 tcgacatggt cagatggagt cgaaaggtga gcggtgtatc tggagaagat cgaaaagcaa 9780 ataaccagct ggaaaatgtt tggccacaac cctctgagaa tccacttggc cttacgagtg 9840 gatggatggt tgatgggtgg aaaccggagc acacgcacag cacaattagc agttatgaaa 9900 agttgaaagt tcattttgtg cagcaacaaa acgaaaatgt gatgaaaagt tcgcactgac 9960 cttttggaat ttttcattgt gaacgaagga gctggccgaa aatgattttg ccaaaaagcc 10020 gtgggcgaca ataaacagat gaagtctgag gcatgtttgc ggtccactta attgcaggcc 10080 aagaagctca tgaaataccc tggtagccac aaactggttg ctccatctgc agaccaaacg 10140 aaattatggg attcattcgc agagggaatg tgcaacaaag caactaaaat gtgagatttt 10200 ccatttgaaa gcccacactt tcgttcgatt tgccacaatt tgcagcatgt ataaagttat 10260 atccgtactg ccatgatatt tctgcatggc agaaccattt caagtttgtc actcgaacac 10320 gcacccaagt gcagaatgcc ggcatgtgag gatgcgagga tgcgaaaatg ccaggacacg 10380 cggaggtggc cggtggcttt tcgatagcgg aggatggtca agccacgagg ggcaccgaaa 10440 cgggaacccg gctcattgtc attttccgac ccgagttggc tttgagcacc tgagaaccag 10500 tcgacccagt cgacccagtc gacccagtcg accagtctac ctgtctacct gtcgaccaaa 10560 tgtggacaca ggctccattc gagatggctg ctcgtcaaca gagccatcaa attgtcattt 10620 tccgaacaaa cgcgttggtt ttcactcgaa attggccgaa aaataaatgt ccttgtaaat 10680 cactcgactt ttatctttaa aatatgattt aaattcagcg aataaaatac ccaatagctg 10740 ataatttatg cccaatttat tatgaattaa aaaaaaaaaa aagatatgaa gatttgatat 10800 taaaatgccc aaaaatacca tatatattac caattttatt gattaacatt tgctcatttc 10860 agtcataaac aaatcctttg ataaagccaa taaaataata ttttaaaaaa ttttaaacca 10920 aacccaaatc ataatattaa tcttatgcac accaaactaa atgttgaatt ggcaagacga 10980 gaatgctaat agtacataaa tcacaactta tcactttggg aaacaaccat taaaaatgct 11040 atttaaaagc agacaaacag cgtaggatgg ctggtacatt tttactggga ttttgctctc 11100 ctttggcaat ctgtcatgtt tttgaagtag gtcctcgtcc tcgacagcat cgtctgccag 11160 ataagaaatg catatttaat aattttattc tttcactcag caggggccct aggagcttag 11220 cttgttttat gactgcgaca aagtaatcct gtgcaaaagg taggaagtgg gaaatcactg 11280 gttccaaagg ggcagattat cagggataca acagagatgt gctcgactta gctggcatta 11340 tgagaagctc gtgtggaaaa attggcccca accaacacac aacacaaaaa tgggcgaagc 11400 caaagttctc gatgtcgatg ttgtttccct tcaatcagcg attcaattta cgagtgccaa 11460 aattcgacac agttttcccc ttagccattt tgccacttgc cacttgccac ttttcactgc 11520 cggctgacac gccccatccg gaatgccgcg aaaatgggcg tgcgaatatt ttgcctttcg 11580 ctgaattcat tgttggccca tggcccacgt tgcggtccgg tttctatttt cagtatatcc 11640 ataaaattaa catttttgtt gcggactctc aaaatcactg agctatggtc ctcgtggtcc 11700 tccagtttgc atttcccagc gaaaagggaa aggggcaaga ggtaaagtgg caacggggta 11760 gagggtgcgt atatggcggc gccacgcgac ggagctaaat ttaattttgt taatgagctc 11820 ggcccctttc cgtttcatca tcccgccaat gggggcagcc agccagccag ccagcatggc 11880

89 gcagccacac tctgccgtcc tattattttg cattcgcaat tctaaaagcc tcaacccgtt 11940 tgtgaggtgg tccgtggttc cagaatccac ttgccaagtg gagcgagtgt gtgtgcgtgt 12000 gttttggcct ttattgcgct cttggtgccc gccaggatta gactgtggat aggcatcggg 12060 attgggattg ggttggggat ggggaatggg gaatgggaat gggaataggg gattgccatt 12120 gggatggcga ttagaacgac aatggaccat tgccggaaac acttgaaaac tgtttcgtgt 12180 tggctgggga ctttgattaa aagcggcacc attgctatca tagcggcaag ccgaaaagca 12240 gaaaacaaaa acaaaacaaa aaaaatgagg gaaaataaac aagttggatc tgacaaagac 12300 attaacattt taattgttcc ggcaacgcaa tggagtcgtg gaccaagcgt aacaattgcc 12360 aatgagtgag ctcgaataaa agtttatggg gtggaggcga agggcagtcg ggaaaatggc 12420 cattaatatt ggagccataa aagtcaaaac ttttcgacgg gtggcaaatg ggaggcgtgg 12480 attagcaata tatcccatgc cgccaggaaa ttgaccctag tcattatttg ccacagagat 12540 gattatgtta ggcaataaac aaacttaagt tttgaatctg ctcgatttgt gaatgaaaac 12600 gccaaaaata tacatatata atctaatgta aatattttag ttatggattt tgaatggctt 12660 ggatttttgt attggttggt aacttctctg tttttccaat tcattgcagc tgcctcggtg 12720 gccgtttcct cctggacact ggtggccatc tcttgcgagc gctactacgc catttgccac 12780 ccgctgaggt cgcgcacctg gcagacgatc aaccacgcca acaagatcat cgccatcatc 12840 tggctgggca gtctggtgtg catgacgccc atcgccgcct ttagccagct gatgccgacc 12900 agccgaccag gtgagtgtgc gccaggataa cactaattca ggaactaacc ccctgtctgg 12960 tcaggacttc gcaagtgccg cgagcagtgg ccggcggata gcctcaacta cgagcgggca 13020 tacaacctgt tcctggacct ggccctgctg gtccttcctc tgctggctct gagcttcacc 13080 tatcttttta tcacccgcac cctgtacgtg agcatgcgca acgagcgagc catgaacttt 13140 ggcagcagtg ggccggaggt caccacctcc tcctctgccg ctgtcgcaga agccggtagc 13200 cagcgacgcg ccaacggaag ccattgtcag tccctcgaca cgattgtgcc acaccagcac 13260 aatcctcacc agcagcacca ccaccattcc cagtactact atggtaaggg gtttatgctt 13320 attttttgag atattcgtag attttttttg tcagccagct gggtcaaagg gaattctggg 13380 ttcagagggt tcagtggcgt agcattaata gttgcgactg ttgccggggg ttggcagggg 13440 gcgtcattcg ggattagctc aactactgag cttatccgcg gacccaaagc ccccgaactg 13500 cgtcacacac aatttgcacg gcaaagtttc ccacgcacga aaagattcgt gtgtctacga 13560 ctcctgccta aatcgcggaa gtgaattgaa tggctggctg ggggatgggg aaagggggct 13620 aaagcctgga ggagcactct gtccaagttt ttcaagcgtg tgtacgaaga gacaatagca 13680 agcgaaagct ctcccggcgt ttttactttc atttgcattc gcatcgccgg ctttaagagc 13740 accacccatg gctagatggc cccttctccc atctacggcg tcctccatcc tctccagctg 13800 cggatgctgt gaataatccc cagattatgg gcacaaaaat tctaggcagc ccaaggcaaa 13860 gccggcgcaa atcaattctg ctaattcgcc tttaatgccg ccttaaagcg tgctcccaat 13920 atatacatat ctctatgtaa atttagaata tattgtagta tatgctcgtc tgcagcagac 13980 atgcttgact gtaaatatag aacagtccca gtggagaggc ctgctgaaga ggaacctcct 14040 cggtgctcca ccatggatgc gagttgataa cgtgacgtgt atgataaatg cacacccaca 14100 aagcgaagtc aaccgtagag tccccgtgga aatcacagtg agcctaccga gcagcgaact 14160 tactttaatc ttcgagaata ttactctgcc tctggtccaa ttaatgttga gaagaggagc 14220 tcctgccacg gaaagatgga agcactgagg caatggagca gtggagcagt ggagcagtga 14280 gtccctgggc gactcatttg catgaaaggg ttggcgcctc caggtggtaa gtcctttatg 14340 cgaaatggaa agtgtgcatt agcaccttca cttgcgccgc actgaattat cgcagcactc 14400 gagaattcat cgagcgattc atttcctagg caactgaccc cgcttgaccc atggaccaac 14460 acggacatgc cagtccaccc gctgctgaaa aaggtcaatt taaatgccgt aaattatgca 14520 cgagacgagc atttaagcgc tcgttaaagg ccgttatccc attgccagga ttctccactg 14580 gagcccgtcg gacgcgtggc actcattttc acacatactc gcactccggt cgcctttctg 14640 tgtgacaata aatttgatta aatttttaac tttttcgttc cgtttaaggc catctcgttt 14700 gacataaccc cgtcataaat ttccaagcca aagagcattt atgtgtgttg gctggatcgc 14760 aaatgtccca tcgccgaaca agctgaacat tttcatggaa attgccatat tattagcagc 14820 ttcacatggc ccccactatt cgtgccaaga atccgcatgc tatccatccc caaactgcgc 14880 gcttgatggc aatttaaatt atgctcagct gaactactcg cccaaccgca aacggcaata 14940 aaattgcgag gtatatggtc tcattccgca cttaagtatc catttccccc ttacatgtat 15000 cccaaatgat tcccatcaca tgctggtagc tacaaatata gtatcctttc catgtaacat 15060 ctacaatgta gcacaaattt tgtgatatat ggatataatc ccttcattgc atcattaata 15120 tctacgtgtc cttctcttga aactcagcca aatgccattc ctgctggcgg tgaggaaggt 15180 gagcggagac acctccaccc tgcactgatc ctcatccgcc agctggacgc agtggtcctg 15240 cagtagtgtg gtcagtgcag ccttcgtctg gagcaggcca agtcgcattc ccggacacat 15300 tcgtggtcca gctccgaagc ccagaaaccg acagcccatt ggtggctgat ttagaaagcg 15360 ttctggacga aactggttgg gtgccggata caatgcggga tctctgaaat cgaaaaagac 15420 tgtagttcgt agacaatctg aagtctcact gaagtgtcac tcacaaatga atggcctgaa 15480

90 ccggcaacac cagcacggtg cccaaatgca ccttaagttc gctgctcgct cctgatttct 15540 gatcaggaag ggtgaatgtc ttggtgcagc gcttctgcag agcctgcatg gccggatgaa 15600 gacgcagtgc ctccaagagc gcagcttcgc tatagcgaag ttcacccaga gccactggat 15660 caatcagatt gccagcgtgg cgctgggcca cttcatccaa ttcgatgtgt aaccgtcgct 15720 gtgcatcctc attgagggcc aattcgtaga gggcgaaggc gagtagcatc gccgaggttt 15780 cgtagccctc cagtaggaga gtggtggcat gtccagctag ctcctccttt cccaagcctc 15840 ttttgctttc cgccagccat tgcaagaggt tgtcgccacc acttcgggct tccaccaatt 15900 ccctgaacca gtgctgcagg ggcaggggta cgtatctgta taagtggata gtggatcaaa 15960 ggttacacat tggcgagttc cacattacca accggtggcc aatgagtcta cccaatcgag 16020 gcgtgtgcaa cagtgacatg gtctccagca aactccaaac gcttggctga aagagcggag 16080 cgagccattc cagccagcga cttggttcat gagccaccct catgtgaatc cccaggcaat 16140 gtgcatccag accgaagatc gcggaggcaa ccacttgtag cgtataacgc gtggccaagt 16200 ccttggcctc gaagcgtcca aggggcacct gatcccggag caactgacat gctctggcca 16260 catgcggcaa ggtctgacgc actcggctgg gtgtgaagag cggcaccagg tcggcccgca 16320 agactcgcca gcggtctccg ttggcgatga agggattgtg gctagccagg acatcgcgct 16380 ggtggtccac ataaacggcg ttgtccgcac agtcggcaaa gttacggccc accaggatct 16440 ggcgcagcaa ctcctggtca cgcaccagaa tggcgggttc gttaaacagg cgatagaaac 16500 ccacatattt caggcccgga ttccgactgt caagaaaagt tcattgcacg tggccttgaa 16560 ggactcttaa gattagtgta tcttacgtat agatttcctg gtaaatctct ccatatgagc 16620 ggcggcccag ggcaaagtcc aacatattcc caaccaatgg ccagccaaaa ggtgcctcca 16680 gtcccaggcg acgccagtga ttgccctgcc atttccaaaa caggagcgtg gcggccaata 16740 ggataaatag caccagtggc agcattatcg atgagcatct gaaaagcttg aaaggcacaa 16800 tcccactcaa cttgcattcc cagttgagtt gaatatctca aagcagctga gagtgaacca 16860 cgttgcgtga ttccatgatt gcgcctcatt agccacgtaa ttgctgtata tcaatcaact 16920 gacgggtatg tttcaatcac gcaagattcg agacagctag cattgggctt tgaattaatt 16980 tctataacca ctatgactca atatgttttc ggataataat cttagtattt caacttatat 17040 gcattgtaca catccattca gttttaattt atttagtgca tttcttctgt tcaaaatttt 17100 gttttttttt tctgtgctta acattcaatt tgacaatcgt atccatttgc gagtcaaatc 17160 agatgtgttt tgtggatacc ctgtaacttt ccatcttgca gattacggcc actgtggcag 17220 caagcggcga ttgatcagcg gaggaggacc ctgcgaagga aggaggcatc tatactgcat 17280 gcggagcgca tccgtgaagt ccctgcgcca tcagcagatc aacggaggag gtggaaccct 17340 aagtggaact ggagctggaa atggcgagtg ctgcagccgg gtgcacagga tgcgccaaca 17400 gatgcagctg cagcagcaag gctacgtgag cgacaatgaa tcccggcgca agtcattgtc 17460 gcagcccagt ctgcgtatca cggaagcggg actgcggagg tgagtgcttc agggtattct 17520 catccacata tgaccgaccg attcgtgtgt cgattttcgc tttcacggta ccttgcagat 17580 ccaacgaaac caagagtctg gagagcaaga agcgtgtggt caagatgctg ttcgtcctag 17640 tgctggagtt cttcatctgc tggacgccgc tgtatgtgat caacacgatg accatgctcc 17700 ttgggccgac ggtgtacgag tacgtgggct atacctccat cagtttcctc cagctgctgg 17760 cctactcatc cagctgctgc aatccgatca cctactgctt catgaacgcc agcttccggc 17820 gcgccttcgt ggacaccttt aaggggatgc gggtgtgcga gcgcctgtgc gctccctgct 17880 gcttctggcg gcgacgctcc aagaacgaga cgaatctttc ggtggccggt aactccattg 17940 cgctggccaa ctcggtcatg tccagccaca cgatcctcga gagtccgcga ctctgagcca 18000 gccgccgccg acggcagatg gccgagtcgg agtcacttta ggttagcaat gggtacggat 18060 cgggagcgct aatatgtgat gatgcaatgt aactgcaata gaaactgtgg ttgtcaacga 18120 cattccgccg cgttctgaat gtgtgtggaa gtggccagat ggataggtgg gtggatggag 18180 gaggtgccat ggcaattgcc cctccaaatt gctcttcatc ttaccgataa gtattttaat 18240 atatgcgtat gtgtgtatgc ttagagttgc gctaaagcgc tttattccgt gtgtgttatt 18300 cgactttgac ctcgcgttcc atgtgtttac accttaaggt gggtgcaacc agtcatgcca 18360 atctaaattg agatcgccac acgctatggg gaatggaaag tgctcagctg gattaagatt 18420 tttaaacaaa caataggcta agaaatcagc acaatggttt cacgacatgg tcacagtatg 18480 tcgtgagcca acaaaatgac ttccaaatgg ggggcgctcc ataaaattgt tttaatttat 18540 ggaaaatggt atatgtgttg gaaggatttg ttggttcaaa tctggagttg ggtcaaaagt 18600 tggtaaacaa ctcatttgtc acacatgtcg tatgagtgat atttacgcaa gctatccgac 18660 cattgtgctg cactttctaa ttttatttcc acactttacg ttccaaagat caatcccaaa 18720 agtaaaaggt attctgatca cggtgcagtg aaaggtttca atgaatcaag aagcatttga 18780 cagcaagctg attttacagg gtacacaggg aagtcccact ctcaaaagga ttcccatcat 18840 tcaaaaatgg ttgtcagacg gagcttatgg agtggcagac actccgaggt ccaaaactaa 18900 attaagaaac ccaatcgggt gccaaaatcc aattttaagt agacgaaagt agctggaaat 18960 gccaatcgga tatattcggg cgggattagc attgtg 18996

<210> 62

<211> 2250

<212> DNA

<213> Drosophila

<400> 62 atgttgccgc gcctgtgcgc cgacgcttgc cgtcagtgct tcgcgaagat tgcgaggcgc 60 gacacacatc gcggaacccg aactccatac ggctgtgccg acactcaatc ccgacctaag 120 cccaattttt tgttgcgtga agttgacgaa gtgtgttgta ctgctgcaag tgcaagtccc 180 cgattgctag tgctattccg ggatcacaaa cgagcatcct tcttcggcct cacgattgac 240 gccttctacc actacctgcg ccaggcgctg ccgctggcca aggaggctgc gatccacctg 300 aatgccagca acgagatctc cgctgtcggt gacggggtca ccatcacagg gacacccggt 360 gatcttctca actacagcgg gctggaattg gatctcggac tggatttgga tcttaatctg 420 gacatggacc tagccactac tcccagcagc agcaccttgg cgccagctgt aaccgtcagg 480 acaccgggga acaggagcgt ggtgagggtc agtgccgatg tgcccatctg ggtggtgccg 540 tgctattcgg ccatccttct gtgcgccgtg gtcgggaacc tgctggtggt gctaacgctc 600 gtccagaatc gtcgcatgcg caccatcacg aacgtttttc tgctcaacct ggccatctcg 660 gacatcctgc tcggcgtatt ctgcatgccg gtgaccctgg tcggcactct gctaaggcat 720 ttcatattcg gcgagctgct ctgcaagctc atccagtttg ctcaggtccc tatccccgtg 780 accgagcccc ataatcgctt gtcaaatggc cacgaaccag cacgacctcg agcggattcg 840 ccagcagatc gtgttggcca acattcagga gctgataaag aagatgacac gtcgctgctt 900 cgacgtatgt atcgctatgc cggaaatgga gttgcgctcc acggagcgcg actgcctggc 960 caactgtatg gatcgattca tggactcggt tcagctgcct cggtggccgt ttcctcctgg 1020 acactggtgg ccatctcttg cgagcgctac tacgccattt gccacccgct gaggtcgcgc 1080 acctggcaga cgatcaacca cgccaacaag atcatcgcca tcatctggct gggcagtctg 1140 gtgtgcatga cgcccatcgc cgcctttagc cagctgatgc cgaccagccg accaggactt 1200 cgcaagtgcc gcgagcagtg gccggcggat agcctcaact acgagcgggc atacaacctg 1260 ttcctggacc tggccctgct ggtccttcct ctgctggctc tgagcttcac ctatcttttt 1320 atcacccgca ccctgtacgt gagcatgcgc aacgagcgag ccatgaactt tggcagcagt 1380 gggccggagg tcaccacctc ctcctctgce gctgtcgcag aagccggtag ccagcgacgc 1440 gccaacggaa gccattgtca gtccctcgac acgattgtgc cacaccagca caatcctcac 1500 cagcagcacc accaccattc ccagtactac tatgattacg gccactgtgg cagcaagcgg 1560 cgattgatca gcggaggagg accctgcgaa ggaaggaggc atctatactg catgcggagc 1620 gcatccgtga agtccctgcg ccatcagcag atcaacggag gaggtggaac cctaagtgga 1680 actggagctg gaaatggcga gtgctgcagc cgggtgcaca ggatgcgcca acagatgcag 1740 ctgcagcagc aaggctacgt gagcgacaat gaatcccggc gcaagtcatt gtcgcagccc 1800 agtctgcgta tcacggaagc gggactgcgg agatccaacg aaaccaagag tctggagagc 1860 aagaagcgtg tggtcaagat gctgttcgtc ctagtgctgg agttcttcat ctgctggacg 1920 ccgctgtatg tgatcaacac gatgaccatg ctccttgggc cgacggtgta cgagtacgtg 1980 ggctatacct ccatcagttt cctccagctg ctggcctact catccagctg ctgcaatccg 2040 atcacctact gcttcatgaa cgccagcttc cggcgcgcct tcgtggacac ctttaagggg 2100 atgcgggtgt gcgagcgcct gtgcgctccc tgctgcttct ggcggcgacg ctccaagaac 2160 gagacgaatc tttcggtggc cggtaactcc attgcgctgg ccaactcggt catgtccagc 2220 cacacgatcc tcgagagtcc gcgactctga 2250

<210> 63 <211> 749 <212> PRT <213> Drosophila

<400> 63

Met Leu Pro Arg Leu Cys Ala Asp Ala Cys Arg Gin Cys Phe Ala Lys

1 5 10 15

He Ala Arg Arg Asp Thr His Arg Gly Thr Arg Thr Pro Tyr Gly Cys

20 25 30

Ala Asp Thr Gin Ser Arg Pro Lys Pro Asn Phe Leu Leu Arg Glu Val

92 35 40 45

Asp Glu Val Cys Cys Thr Ala Ala Ser Ala Ser Pro Arg Leu Leu Val

50 55 60

Leu Phe Arg Asp His Lys Arg Ala Ser Phe Phe Gly Leu Thr He Asp 65 70 75 80

Ala Phe Tyr His Tyr Leu Arg Gin Ala Leu Pro Leu Ala Lys Glu Ala

85 90 95

Ala He His Leu Asn Ala Ser Asn Glu He Ser Ala Val Gly Asp Gly

100 105 110

Val Thr He Thr Gly Thr Pro Gly Asp Leu Leu Asn Tyr Ser Gly Leu

115 120 125

Glu Leu Asp Leu Gly Leu Asp Leu Asp Leu Asn Leu Asp Met Asp Leu

130 135 140

Ala Thr Thr Pro Ser Ser Ser Thr Leu Ala Pro Ala Val Thr Val Arg 145 150 155 160

Thr Pro Gly Asn Arg Ser Val Val Arg Val Ser Ala Asp Val Pro He

165 170 175

Trp Val Val Pro Cys Tyr Ser Ala He Leu Leu Cys Ala Val Val Gly

180 185 190

Asn Leu Leu Val Val Leu Thr Leu Val Gin Asn Arg Arg Met Arg Thr

195 200 205

He Thr Asn Val Phe Leu Leu Asn Leu Ala He Ser Asp He Leu Leu

210 215 220

Gly Val Phe Cys Met Pro Val Thr Leu Val Gly Thr Leu Leu Arg His 225 230 235 240

Phe He Phe Gly Glu Leu Leu Cys Lys Leu He Gin Phe Ala Gin Val

245 250 255

Pro He Pro Val Thr Glu Pro His Asn Arg Leu Ser Asn Gly His Glu

260 265 270

Pro Ala Arg Pro Arg Ala Asp Ser Pro Ala Asp Arg Val Gly Gin His

275 280 285

Ser Gly Ala Asp Lys Glu Asp Asp Thr Ser Leu Leu Arg Arg Met Tyr

290 295 300

Arg Tyr Ala Gly Asn Gly Val Ala Leu His Gly Ala Arg Leu Pro Gly 305 310 315 320

Gin Leu Tyr Gly Ser He His Gly Leu Gly Ser Ala Ala Ser Val Ala

325 330 335

Val Ser Ser Trp Thr Leu Val Ala He Ser Cys Glu Arg Tyr Tyr Ala

340 345 350

He Cys His Pro Leu Arg Ser Arg Thr Trp Gin Thr He Asn His Ala

355 360 365

Asn Lys He He Ala He He Trp Leu Gly Ser Leu Val Cys Met Thr

370 375 380

Pro He Ala Ala Phe Ser Gin Leu Met Pro Thr Ser Arg Pro Gly Leu 385 390 395 400

Arg Lys Cys Arg Glu Gin Trp Pro Ala Asp Ser Leu Asn Tyr Glu Arg

405 410 415

Ala Tyr Asn Leu Phe Leu Asp Leu Ala Leu Leu Val Leu Pro Leu Leu

420 425 430

Ala Leu Ser Phe Thr Tyr Leu Phe He Thr Arg Thr Leu Tyr Val Ser

435 440 445

Met Arg Asn Glu Arg Ala Met Asn Phe Gly Ser Ser Gly Pro Glu Val

450 455 460

Thr Thr Ser Ser Ser Ala Ala Val Ala Glu Ala Gly Ser Gin Arg Arg 465 470 475 480

Ala Asn Gly Ser His Cys Gin Ser Leu Asp Thr He Val Pro His Gin

485 490 495

His Asn Pro His Gin Gin His His His His Ser Gin Tyr Tyr Tyr Asp

500 505 510

Tyr Gly His Cys Gly Ser Lys Arg Arg Leu He Ser Gly Gly Gly Pro 515 520 525

Cys Glu Gly Arg Arg His Leu Tyr Cys Met Arg Ser Ala Ser Val Lys

530 535 540

Ser Leu Arg His Gin Gin He Asn Gly Gly Gly Gly Thr Leu Ser Gly

545 550 555 560

Thr Gly Ala Gly Asn Gly Glu Cys Cys Ser Arg Val His Arg Met Arg 565 570 575

Gin Gin Met Gin Leu Gin Gin Gin Gly Tyr Val Ser Asp Asn Glu Ser 580 585 590

Arg Arg Lys Ser Leu Ser Gin Pro Ser Leu Arg He Thr Glu Ala Gly 595 600 605

Leu Arg Arg Ser Asn Glu Thr Lys Ser Leu Glu Ser Lys Lys Arg Val 610 615 620

Val Lys Met Leu Phe Val Leu Val Leu Glu Phe Phe He Cys Trp Thr

625 630 635 640

Pro Leu Tyr Val He Asn Thr Met Thr Met Leu Leu Gly Pro Thr Val 645 650 655

Tyr Glu Tyr Val Gly Tyr Thr Ser He Ser Phe Leu Gin Leu Leu Ala 660 665 670

Tyr Ser Ser Ser Cys Cys Asn Pro He Thr Tyr Cys Phe Met Asn Ala 675 680 685

Ser Phe Arg Arg Ala Phe Val Asp Thr Phe Lys Gly Met Arg Val Cys 690 695 700

Glu Arg Leu Cys Ala Pro Cys Cys Phe Trp Arg Arg Arg Ser Lys Asn

705 710 715 720

Glu Thr Asn Leu Ser Val Ala Gly Asn Ser He Ala Leu Ala Asn Ser 725 730 735

Val Met Ser Ser His Thr He Leu Glu Ser Pro Arg Leu 740 745

<210> 64

<211> 4289

<212> DNA

<213> Drosophila

<400> 64 agctgtaaag tactactact acatatgtgt acattcaagt ttcgcttacg aatgcaacgt 60 tccattaaag aagccaccaa ctttaagata cacgcatata acaactcctg agaattgtga 120 aaactgatct actttgatga tcaactttca ttgctgctga ttgaataatt gagtaatgag 180 taattggtat gctgataaac aggaaaacca aaatgtcaac agttgataag gaacattaaa 240 acacaaatta agaggacggt aagtccttca ctcggacctt ttcagctgag caccgtaaag 300 tgctgaaggg attgccccca cacccagacc gcgcccactt ccacttccac tttaaaataa 360 tcatcatggc cctctttttt ggccaggctg cggtggcttt gggccttaat tgtcgactca 420 gttgctgtgc tgtgctgtgt actcgacaag gcgacgaacc gagagccttg cagctccata 480 atgacaggcg gatggactcg aacactcgga cccggacccg gacccgaacc cggacccagt 540 ccacagccag gacataagcg gcttgtgctc cactcaactg tcgcctttcg gagctgctcc 600 tagcttgcaa ttaaaatacc cacttgggcc ctataaattg tgaacgtagg aaggcaggcg 660 gaaaaaaaaa aaaatattcc agcactttgg tgtatggagt ggggtccact taattcccag 720 gtactcaccc aaaaggattc caactataaa gacatacagc gagagtgctt aagttttact 780 ctgtttattt gcagcaacct taggaagttc aattgaaaca ccaatagact agcgtctgag 840 ttattttacg agtacgatca taatcacaag taggtaaaaa aaatccatat tcgccttact 900 taaaacaaaa aaaaaaacca cacgcagatc gcttatcata catatttaca ccgcatctcg 960 ttgatcctga atgggtcctt ggaggcgaat cctctacagc ttagagctga ggactgttga 1020 cggcggcggc ggcactattg gtggtcacca ccgcattgag aaactcgtgg cgtgagcgac 1080 tccgccaggt gcccataccc atggctaggc cgggattgag actaatgttg gtgttggcac 1140 tcgcataggc gcccgggcct gcgcccgcct ggctggcgga gagtcctcca ccagcagcac 1200 caccgacgcc tccgctggca cctgctccac gacgccaggg cagacccttg aaggtgtcga 1260 caaaggcgcg ccggaagctg gcgttcatga agcagtaggt gatcggattg cagcagctgg 1320 atgagtaggc cagcagctgg aggaaactga tggccgtgta gtcgacatac tcgtacacca 1380

94 ccggtccgat cagcatgacc atcgtgttga tcacgtacag cggagtccag cagatgaaaa 1440 actccagcac caggacgaac agcatcttga ccacacgctt cttgctctcc agggtcttgg 1500 cctcgttgga cctggatagt ggattgtgga ttgtggagaa atgggaatag ggaataggat 1560 tggcagaccg gttatcggac acgaatccta cctgcgaagt gccgcatcgt ggacgcgaat 1620 gctgggcgag gaggtcttgg ccagcgtcac cgtggtcgtc gtggtggtgg tgatcacagt 1680 tggagccgtt ggtctcgttg tcaaggtggt cgttgccata ttggttgatc ctccgcctgc 1740 ggatccctct gaatttccat tattattgtt actattttct atgtgaaaaa aaaaaaacat 1800 gtgaacacaa gccaaatata atcaaacaaa ttaacgttat tagcagcaac aaataaaaca 1860 gttgccataa ctaatctaaa ctaatacata gacgtaaaat aattaaattt tcaatttggt 1920 tttaagagtc tcaaaaataa tatagcatat tatgttaagt ggatttgtac cttcttatcg 1980 agcatttcac caacaatcta tatctttaaa gtattatgcc atattacatg tcatgtaaca 2040 ttaaataact tatgagttat gatatttaga tgcaaaataa tacttgaatg cattcataaa 2100 tgctcttaaa gttgtttgca tattcatggc ttttaaggat tgaaaaagga ttagtttcgt 2160 gcagttacca accattatag actgcggtgg cggtcaggac caggatgcag ttactactgc 2220 tgctggtgcc cggattcggt gcgcttccgc cggccgttgt agcggaaaca ggcagcgatt 2280 gctgcaggat gcgtccgctg tccttggcca tgcctacgta cagggtacgc gtgatgagga 2340 tgtaggccac gcagaggacg agaagcggca ggacgagcag caggaagtcc agcaggatgt 2400 tgtagaagag ctcgtatccc tggtcgggcc aaaactcacg gcacttgcag tagcctgtaa 2460 cgtaagttgg tataacaacc agacggtgtc tgctggccag gttgctatgc actcacccgg 2520 tcgactggtg ggtatcaatt gactaaagac cgctatgggc gtcatgcaga ggatgccgcc 2580 cagccagatg aagccgatga tcttgtaggc gtgactgatt gtctgccagg atcgcgagcg 2640 cagtggatgg catatcgcgt agtagcgctc acaggatatg gccaccaagg tccaggacga 2700 aacggccacg gaggcggctg aaataaataa atgaaagcgg attaacttac aacaaaccga 2760 acacaatgga cacacccagc agctcctgtc gagcgccgtg tcaaatcgct ttcattagaa 2820 ggtccttcgc ccgcgttcgt tgcattttaa ttacacaatt tgcatattgg gaccagacga 2880 accgtaccaa ccagacggac ggagacatcg ctcttcgcac ttctgcctgt tcttgtagta 2940 tgacaaacac gatgcacgat gcaatttgca gaaagtgcaa ttaagcaatt ccccagccac 3000 tccttttctt gttgcccggt ctccttttca tgtaagcctg ttagatgatt tcccattgta 3060 aagcaatttg tacccacacc ctgcccatcc ctcatattct tttgggctac cactatcgat 3120 ggggctacac aagtgcaagt caatagggtg gactgctgta ggtgaaaaac tcgacaccga 3180 aagaaaaaga cccgattcga aaaattggtc aattttagcg caattaaatg agaaataatt 3240 tctagttttt caatcgattg ttttatagca ccaaatcata tatcttaacc gtaaaggcat 3300 caaataaata tgataaactg atcaaatgaa agcataattt gcttgtatgt atgcgtgttt 3360 ttggaattta tagcttacca aaacacttgt gaaatttgca aatatacata tttgttcata 3420 cacaatttag acttcaatgc aataagctgt aaggtctatg gtttcaatta ttaatactcg 3480 gaaattgttg tgctagcaga tacatttgtg gtttgttaga tatacatatt tgcttataaa 3540 gatatatatg tatgtacgta ttgcattcaa aagcaataag cagtaaggta aattggatca 3600 agggacgagt atttaagaca gcctgtatat gttcccttta ctttaatgcg acacctcatt 3660 caggcaatta aggtccaccc taatgtgctt atcccttcag ccatctgcag ctgcattgta 3720 ttatattgga atggtatttt ctcgcaaaat gatatgcaag ttttagattg atacgtacaa 3780 ttgcagtgat tactacttta gttacgaatg atgataggtg atgtagtaga tatatatttg 3840 ctaccaaaga tagttacacc ttagaatcct aaaagaaata agtgttttgt agtcgcagtt 3900 cgtttctcta gttcaacaca tccagccaac caaggtccac cctaatgtga ctgcacttca 3960 gctgcactgt attatattac attttagctg cacaattgtt tactttctat tttaattatg 4020 catgcaaact aatatgagca gtaaagatgg attacctcca cctgttccgt tggagtgcat 4080 cccgtccagg caaccaaggt ccaccctaat ggggtagccc ttgcccttcc aactgcattg 4140 tcacattggt ctcgccctct gtcgcgtttg ttgagttaaa cccctgaaat tgaagtttac 4200 ttttgattga cggcggtgtg tgatgctcta agccagaaat gctagcatgt gtgcgcttaa 4260 acttaaaaca aacagcagca tggcatttc 4289

<210> 65 <211> 1248 <212> DNA <213> Drosophila

<400> 65 atgcactcca acggaacagg tggagccgcc tccgtggccg tttcgtcctg gaccttggtg 60 gccatatcct gtgagcgcta ctacgcgata tgccatccac tgcgctcgcg atcctggcag 120 acaatcagtc acgcctacaa gatcatcggc ttcatctggc tgggcggcat cctctgcatg 180 acgcccatag cggtctttag tcaattgata cccaccagtc gaccgggcta ctgcaagtgc 240

95 cgtgagtttt ggcccgacca gggatacgag ctcttctaca acatcctgct ggacttcctg 300 ctgctcgtcc tgccgcttct cgtcctctgc gtggcctaca tcctcatcac gcgtaccctg 360 tacgtaggca tggccaagga cagcggacgc atcctgcagc aatcgctgcc tgtttccgct 420 acaacggccg gcggaagcgc accgaatccg ggcaccagca gcagtagtaa ctgcatcctg 480 gtcctgaccg ccaccgcagt ctataatggt tggcggagga tcaaccaata tggcaacgac 540 caccttgaca acgagaccaa cggctccaac tgtgatcacc accaccacga cgaccacggt 600 gacgctggcc aagacctcct cgcccagcat tcgcgtccac gatgcggcac ttcgcaggta 660 ggattcgtgt ccgataaccg gtctgccaat cctattccct attcccattt ctccacaatc 720 cacaatccac tatccaggtc caacgaggcc aagaccctgg agagcaagaa gcgtgtggtc 780 aagatgctgt tcgtcctggt gctggagttt ttcatctgct ggactccgct gtacgtgatc 840 aacacgatgg tcatgctgat cggaccggtg gtgtacgagt atgtcgacta cacggccatc 900 agtttcctcc agctgctggc ctactcatcc agctgctgca atccgatcac ctactgcttc 960 atgaacgcca gcttccggcg cgcctttgtc gacaccttca agggtctgcc ctggcgtcgt 1020 ggagcaggtg ccagcggagg cgtcggtggt gctgctggtg gaggactctc cgccagccag 1080 gcgggcgcag gcccgggcgc ctatgcgagt gccaacacca acattagtct caatcccggc 1140 ctagccatgg gtatgggcac ctggcggagt cgctcacgcc acgagtttct caatgcggtg 1200 gtgaccacca atagtgccgc cgccgccgtc aacagtcctc agctctaa 1248

<210> 66 <211> 415 <212> PRT <213> Drosophila

<400> 66

Met His Ser Asn Gly Thr Gly Gly Ala Ala Ser Val Ala Val Ser Ser

1 5 10 15

Trp Thr Leu Val Ala He Ser Cys Glu Arg Tyr Tyr Ala He Cys His

20 25 30

Pro Leu Arg Ser Arg Ser Trp Gin Thr He Ser His Ala Tyr Lys He

35 40 45

He Gly Phe He Trp Leu Gly Gly He Leu Cys Met Thr Pro He Ala

50 55 60

Val Phe Ser Gin Leu He Pro Thr Ser Arg Pro Gly Tyr Cys Lys Cys 65 70 75 80

Arg Glu Phe Trp Pro Asp Gin Gly Tyr Glu Leu Phe Tyr Asn He Leu

85 90 95

Leu Asp Phe Leu Leu Leu Val Leu Pro Leu Leu Val Leu Cys Val Ala

100 105 110

Tyr He Leu He Thr Arg Thr Leu Tyr Val Gly Met Ala Lys Asp Ser

115 120 125

Gly Arg He Leu Gin Gin Ser Leu Pro Val Ser Ala Thr Thr Ala Gly

130 135 140

Gly Ser Ala Pro Asn Pro Gly Thr Ser Ser Ser Ser Asn Cys He Leu 145 150 155 160

Val Leu Thr Ala Thr Ala Val Tyr Asn Gly Trp Arg Arg He Asn Gin

165 170 175

Tyr Gly Asn Asp His Leu Asp Asn Glu Thr Asn Gly Ser Asn Cys Asp

180 185 190

His His His His Asp Asp His Gly Asp Ala Gly Gin Asp Leu Leu Ala

195 200 205

Gin His Ser Arg Pro Arg Cys Gly Thr Ser Gin Val Gly Phe Val Ser

210 215 220

Asp Asn Arg Ser Ala Asn Pro He Pro Tyr Ser His Phe Ser Thr He 225 230 235 240

His Asn Pro Leu Ser Arg Ser Asn Glu Ala Lys Thr Leu Glu Ser Lys

245 250 255

Lys Arg Val Val Lys Met Leu Phe Val Leu Val Leu Glu Phe Phe He

260 265 270

Cys Trp Thr Pro Leu Tyr Val He Asn Thr Met Val Met Leu He Gly 275 280 285

96 Pro Val Val Tyr Glu Tyr Val Asp Tyr Thr Ala He Ser Phe Leu Gin

290 295 300

Leu Leu Ala Tyr Ser Ser Ser Cys Cys Asn Pro He Thr Tyr Cys Phe 305 310 315 320

Met Asn Ala Ser Phe Arg Arg Ala Phe Val Asp Thr Phe Lys Gly Leu

325 330 335

Pro Trp Arg Arg Gly Ala Gly Ala Ser Gly Gly Val Gly Gly Ala Ala

340 345 350

Gly Gly Gly Leu Ser Ala Ser Gin Ala Gly Ala Gly Pro Gly Ala Tyr

355 360 365

Ala Ser Ala Asn Thr Asn He Ser Leu Asn Pro Gly Leu Ala Met Gly

370 375 380

Met Gly Thr Trp Arg Ser Arg Ser Arg His Glu Phe Leu Asn Ala Val 385 390 395 400

Val Thr Thr Asn Ser Ala Ala Ala Ala Val Asn Ser Pro Gin Leu 405 410 415

<210> 67 <211> 9249 <212> DNA <213> Drosophila

<400> 67 caaaataaat gtatataatt tcaaaattga catttgctaa tgataagcct ctgcctcatg 60 cccatgctta tgctgaaata tggacaaaat tcgggcacag agcaagagat gcgcagagca 120 gctgccatcc ggaatggaat gagttggaat ttgggcagca gatggcgctg tcgcaaaagg 180 aaggaagcta aatttcactg ggccccaacc aaacggaaat ttccacccac ggctcagaaa 240 ttgaagctgt ttatggtaaa ttaaaccaat tgagtgggat tacgttttgc gcactacaac 300 aacgccacca acctccgcat caactccgca atctccgaca ccccgaagtg tttccaactg 360 ggtttcaatt tcactgtctg gacgagcctg cggctaacga aatttatata cccatacaat 420 gccatcaaag ccacaaggtg tttatgggct taactccggc cctgattccg cctacttggc 480 tgcctcgcct cacagatttg gatttgcatg tgccacgatt tggggcatgc ggctgagaag 540 gcggctgagc aggcggatag aagacaaata gccagcacgt tgcggttcat ttggctgtca 600 caacaaatgc cgaattgatg caaatgtaaa tggattcgat atccaggaac gcgtcgtcgg 660 aatcccaagc agcagtcaag tgatgaatac acggcttaaa agatactgta ttaacttaca 720 gtagcttacc ttcaaagcaa aaattgtaga tttcattctc tagtaacgag ttcatatcca 780 tacctcttta atattggata ctatttatta cccagtttat tacttagttt ttatttcaga 840 atcaaaaaca aatataagca agcttacccc atttaagtac ttggcaattg caaatgtgca 900 cataccactt tcttttccat ccacaaactg gctttcaaac tgctgttggc caactcataa 960 atatggcaga caataaatct agattctttt tcaattgcag ggtttggcaa acgattggca 1020 ataataggag tcatcaaaac gagagcaaat gtcatacagc atgtcgtcct tattccgtgg 1080 cgttagtgcg acatttggag ttggaaacta ggagcccact tagactaaca acgcccgtga 1140 ccattaccat gacgctactg cagaggcttc aggccatgtc ggccaccacg accaggacaa 1200 tactggaggg cagcatcagc agttttggtg gcgggacaaa tgagcctctg gcgagcaaaa 1260 tacccgttct ggaggagtca gcctcacatg ccagatattt gaaattcatt gccgacgggc 1320 tcatcgacga gggactgggc agtgcggtgg gcagtgggag cagcatcgcc gtatccgttg 1380 aagacgtggt cgccggacag gcgcaggaca tccaggcgag cgaaggatcc accgacgacg 1440 ccgacggcag tagccatttg gcattagtct tcgtcaagtg tttcattatt ggtttcatca 1500 tactggccgc catcctgggc aacatgctgg tgattgtgtc ggtcatgcgg caccggaaat 1560 tgcggtgagt ccttgccatt gtgcgttcta gccatatccg ttggtcagga catgtgtgtc 1620 ctcaaatgtc tgggtttcat taatttgtcg ccatgaatca ggtggctttt ttcccttttt 1680 gcgccatggt ttcaatttca ttgtgtgcat ttggcaggaa gcttccaact ataagttact 1740 tagataataa tttaacaaag catgaacttc aacatcaaaa cattagtgag caaatattaa 1800 aagagccctt actttcgctt ttgtttaagg taaattgccc gagctgtaac ctgccacatt 1860 gtccacgaat cgtgggtgtt ttagctgtca aggacatgac ttgtacaccc cacccccccc 1920 gccccttttt ccttttattt ctttgtttgc tcctttttgc cgaacgattt tgtgcgattt 1980 gaccgcgttc ggcttaacga gtagctacct cctttttttg cggccattaa tttgtcatca 2040 tttatcatat tttccatcat ttttgcgtgt caagcgcaca gaactcatct cgttcgccca 2100 ccgaacactt cagagggggg cgtggttggt tgactaagtt aaatgctaga tacgtgcgta 2160

97 attacattag aaatgttaat aaggggcgag cataaaaata ttgttgccta cttacggggg 2220 cgccattggc atttacttta tgtgcggcca tataatttgt caaatttatg aattgggcgc 2280 caccttcaca tgagatatgg ccacgtgggc gtttgaggga tttccaggta tccaggtagc 2340 aaagtacgta cgtgtttcag tcgcaaattc aaaagcccaa caccgctggc atttaaagaa 2400 cccaacataa aacacttgga gagaggcgac aatggtgtaa cctaaccccg ggacattcaa 2460 tgtcaaggcg cagactatta aagcagcccc gggaaaacgt cttccactgt cattgccgta 2520 ttcctttcgc cttggaacca accaacgcac acctgacatt tgtggctgcc accgagaatg 2580 aggatgggca tggtgatgag catgggggat gaggctcatt tagcctgcca gggacaggca 2640 atttgggacc tgaccctgac tactacgtgt atgccatgtt gccgttttta tctcaactgc 2700 cttgcgccag catctctttc attattgttg ggctcattgt catgtgcgtt ttccgcacca 2760 ttttcacctt ttccgcctcg ctaggcagtt taaatcatca cggcaaatta gacttaatta 2820 cgaaacaaca tgcattccca cttaggtccc atgctaccta aaaaccttgt gaccaagcgg 2880 agtagcaggt atctatttca atgttctgga taagccatct gggcgacagt tgtgcgactt 2940 tttcacgact ggccactcaa cttacattat tcatgtcaca cgcatcgata aagtgggtga 3000 caaattaaag tcagactgca gatcaagtac gaggaagagc cgggaaagtg tttcctcact 3060 tttcctatta attagagctt tccacgttgg ctgcctgccg aaagtgtcga ctcataattg 3120 taatcaaact tgacacccaa caagtttcct cctttcattc ccgagcaccc actatataat 3180 cggcttttgg gtaacgcctc aataacattt tcgtgttgcc tctgatgcgg gtgttttgcc 3240 tttgtacttt ttgggcgctt taagcttgct ccaaaaatgt agacctttcg gggcgtcagt 3300 ttgtggccgt aattaggttt gcgggagatg gtttaatgtc ccagtgaaat atggcaaaat 3360 ggcgagcgat tgttaacgag tttaatagat aaaggtcgga tacacataaa aagaatatcc 3420 atgattgatg cagtttaaga agttcccatc caaagttcct tcattcaaaa gtttatctgg 3480 cacattaatc cgtttagacg gaaagcaaaa ctttcatttg cgatgttgtg gtacgaagag 3540 tcaagttccc gcagatgtta tggttttaaa catgaattcc aaccgcccat tcggttgcgg 3600 ttatatccgt ggaatggcgt tatgtacgcc tgattgtttg gaaatcagtg cggacggccg 3660 ataaacgcat ttgctgctcc acatagcgta tacgccgcgt gcacctaatt gacttaacgt 3720 tttgcggtgc cacgcaacgt tgatgatcgc tggtggaagt tgcggtggcg ttaagctaat 3780 tattaattaa cccattaaac aatgaaatcc actcagagaa gcgccttttc gtacatgaaa 3840 cggcggtcac acgcggcgta tgcgcaatgt gcgcaccaaa gtttccaact caagttggac 3900 agcaatccga agtaacgatt agcgctgcga gctctgagtg acttgaaagc ttaatgcaca 3960 aatttaattt gagaacttgg cactctcaat accactggca ctcaggcttt aggttcattc 4020 tgccattttt ggttgactgt gtggcttccg ccttggttcc tgctaagttt taacctagca 4080 tttactcctc ctccttgcag catcattacc aactactttg tggtctctct ggccgtcgcc 4140 gacatgctgg tggccctctg tgcgatgaca tttaatgctt ccgtcatgat ctcgggcaag 4200 tggatgtttg gttccgtgat gtgcgacatg tggaacagct tcgacgtcta cttctccacc 4260 gccagcatca tgcacctctg ttgcatatcg gtcgacaggt gagtcccggg tttactttgt 4320 cattgtggaa taattgaagt tccgagtgct actgggatgt cttttatacc ttcctttaaa 4380 tgcccatcaa attgaatagt tgcttgacag tttctagtga caatcttttt tcccctttac 4440 ccgtagatac tacgccattg tgcagccact ggactatcca ctaatcatga cacagcgacg 4500 cgtgttcatc atgctattga tggtgtggct atcgccggcg ctcctctcgt tcctgcccat 4560 ctgctcggga tggtacacaa cgaccgagaa ctacaagtat ctcaaatcga atccgcatgt 4620 gagtagctta cttgaagccc ttaattggga caattaaata tttgtacaat agtgtataac 4680 tctattatgg agcccacaga tttgatgagt aggtcgatcc ggtgtatgca cctacattat 4740 ttattcaatt ttcttgcaca tcaaactaat agaaaattct aatttagttg aaacggtatc 4800 gactttgcat gcattttgca tgccttcgat gccacgtggg cgtccatgtg gcagtggcaa 4860 cctttgactt ttcccccgac ccgcctcaac ggaaattgat ttatgtttgt gtggctgaag 4920 cagttttacg cctttcaggc tgccagccga caggtagcat atttattact ccattttatt 4980 ggtttcctcc gcaaatactt ggcaaactcc ttggcagcac ctcctccatc tacaaatata 5040 tacatttata tatatatata tatatatatg ttctctgccc gtcagcagct gctggtactg 5100 attccccccg ccactgcggt tatcattgcg caataaaatg ctgatgtaga aataaatgta 5160 ggtaattcca ttccggtttt ctgcgctccc attcaggctg acttcagcat aggctgtgca 5220 taattttcgg ctctacacct ggaaggacgc ctgaaacgcc tgacaggcct ttgcatacat 5280 tagcatccgc ggtgggcttt aattagtttt acttgtttat gctaataact gtcagcgcga 5340 agccggcaga atgtcctggc cgtaaatctg attagatgtc ttctggtggc cttttgtcat 5400 ggcagcgctg taatgcacag cgtaattgag tttttattgt cgcacttggc attgcagtaa 5460 tcgcattgcc attgcaattg ccgtcgcaat agccgttgct catacgcaac gttggccgcc 5520 gccagccgca gttggcaatt gccgagcatt acgctccatt acggttcgcc actggcatcc 5580 gactgcactg ctccaacgtt cattttgatt tattgatagt cgctaattga gttgcccatc 5640 aaatcgcaac gatttcgatt ccgatttcga tgctcccctc actccatatt tcagatatgc 5700 gagttcaaag tgaacaaggc atacgccata gtcagctcgt cgatgagctt ctggattccc 5760

98 ggcatcgtaa tgctgtcgat gtactaccgc atttaccagg aggccgaccg acaggagcgt 5820 ctggtgtaca ggtaatagct attcgagtgg cccctccatt tgcccgcttc caattaactc 5880 taattactta ctgtgtgcgc ccagatccaa ggtggccgct ctgctgctgg agaagcatct 5940 gcaaattagc caaattccca agccccggcc gagcattcag gtggagcagt cgaccatctc 6000 gacgatgcgg cgtgagcgga aggccgcccg caccctgggc atcatcatga gcgccttcct 6060 catctgctgg ctgccgttct tcctctggtg cgtatacttg atggctcaaa ttgggcaatt 6120 atcgctagca ctctaaggat caagtgccga gaagttttta attaactcgg gctcatatca 6180 aataatttgc actttccatg ctacaggtgg gcggaaagtg tgtataaaca attaacaata 6240 caagtatgtt tccttgggat tgaaatataa gaaaggcaat gtagacttaa gcagtagtta 6300 ttatgcacta ttcaagtatc tattccacct acttaaaagt aaagaatcta acactttccc 6360 tttctccaat taaaccgcag gtacatcgta tcctcgctgt gcgatagttg catcactccg 6420 cgcctgctcg ttggcatcct gttttggatc ggctacttca actcggccct gaaccccatt 6480 atttatgcat acttcaaccg cgacttcagg gccgccttca agaagaccct caaggtgagt 6540 tgcgggctgg ccatcgagta atttgcatat accttccact tcgacatctt gatgggactt 6600 ttattctatt caatttcgct ttgttcgggc atccaaaact gaattctctg caccacctta 6660 gacttagtac agggcttcgg caactgctgc aatcgcaaag gacagggcca acgccaccca 6720 ttgcacagaa gcggcggcgg ccaccatttc gacaacagta tcgactggca acgcggaggc 6780 gccaccacca gcgccccacc gacgaggctc acgtttagca attattttgg tagctattgc 6840 atagcatcac gggtgcactg agaaaaaaca tgaacaattt atcaaatata ttaagtaact 6900 tggagtaact tagttccagt tacacgacta acaaataaga aaaaagatat ggaaaaaaga 6960 acattgtctc ctcatttttt ctcagtgcag ctcagtgttc cgcggagagc gtagatagcg 7020 tagcgttcat attagttgat tgaaatgctt cttcatccac atctactggt tgctaagcaa 7080 acaaaatagc ttttcctctg cctgaagaac tgaaaactct gcacgttctt tgctctacag 7140 ctctacagct ctgcctgcgc ctgcctctgt ctctctatca gtttcattct cgagggtatc 7200 tttcgggcat ggtgaatggg acagtgaatg ggggttgcaa tgcttgggct ttctaatcgc 7260 ttgaacactc tgcttgccac ttaccatcgt atactaccat ttgccatata tagtgccata 7320 taccatatat catttctctt tgcacgcata gctggcgctt actgtgctga ttcgttgcct 7380 atggcccaac aaaagctaag cccgccaaag tatgcaacag caaaacagaa agcataaaac 7440 gtaatattta aattaaaacg gaacctcttc tttgtatgta tgcccagcta caaccagcta 7500 cacctacacc ttctccacat tcatacaagc gtaaatgctg atgatgaaat gttattcttt 7560 ctctaaaaat tctccctttt atgctgcaca cttcgacaca ccagcaacac caacaccaac 7620 acacacacac acactgaggc acatggacgg gtccttgttc gtcccttttt tttatatgaa 7680 tgcgcggcct ttcatttcgt ttagcatttt ttgtgtgagt ctgttgtttg ttttttgttt 7740 ctttcccttt agcctttgtt ttctgtgtga aaccaaattg tcacagacat gtgccgccag 7800 cacccgaaaa aaaaaaacac catacccctg tcgattgtgt cgcccgtccc acgcggcgta 7860 tgcttaacct ttgagtgctg tacagtagcg agctaactct attaaattac atagcgtact 7920 ctaacggtag catgcgagtt tatctcatct actcatagtt gggtgtcctc ttcattccac 7980 agagtctgtt tccctacgct ttctacttct gtcgacgtgg cagggggcga gacgatgacc 8040 gggatctgga gttcggcggt cccagccgac ggggaaccaa tggagcccaa cggaccggat 8100 ccggatccgc cgagatggcc aactgcgtca actccacggc ctcgtcggag atacacatga 8160 gcgtgatgcg tgcccgccag tatgccgtca atgtcacacc caccacggac gcccagatgc 8220 agcagctgca tcccctgtac accaactaaa cgaaaaacac atatggcgta tacttgattt 8280 caactccagt gcttcacaat gtctgttcat gagatgagtg cgcagtgcac agcaagtgtt 8340 ctccagaaaa ccagattgcc agcttacaaa tacaaatcac tcgataaaaa cattcctcaa 8400 aatggctgct aagagggcta aacaagaatt taaccacaaa taatagctaa agcaacagcc 8460 acagcaacaa tacgacaatc ccacagatta aataaagcct tcaagagcag caaattgacg 8520 tgcaaaataa attgaaatct tatagaagta tgtatttcga catacaatac atatttaggt 8580 gtcatggagt caggaatttc ataacgagat gtttataaat gcgcatgcaa atagatatat 8640 gaatttgaat gtttgatata cgtatataaa aagatagatg ttaacccaca aaaaaaaaaa 8700 taataaaata tgaaatatgc attgattggt aatctaaaac gaatcgcaaa ttaaagctac 8760 actgtgcaac agtggtatgt agtgagaaaa aaagtgtagg ttcaaggtct ggttgaaaga 8820 aaaaaatttt taatctgttc aattatttga aatattaact ttaaatacga tcaaacttat 8880 ctggtccttt cacattttat tcgattagcg aataaagact gacaatttta ttttatcagt 8940 gacttaaaaa tgatttaatt aaaacattat ccacatattc aaagtactta accaggcctt 9000 aaattcactt taactctcca ataaacaaag ataactaatg ttagttgtag cagagtgttc 9060 gtattgtttg taaaactcat actctcagtt ctgttagatg taatgacaaa gctttgattt 9120 gattcgttaa atacattaaa ataatctagt tcattgaaaa acaatcaaat tatatatgtc 9180 ataatactta catacatagg tattcatatt cataaagaat acatataggg cctaaagcgc 9240

99 acgactaac 9249

<210> 68 <211> 1675 <212> DNA <213> Drosophila

<400> 68 ggtttggcaa acgattggca ataataggag tcatcaaaac gagagcaaat gtcatacagc 60 atgtcgtcct tattccgtgg cgttagtgcg acatttggag ttggaaacta ggagcccact 120 tagactaaca acgcccgtga ccattaccat gacgctactg cagaggcttc aggccatgtc 180 ggccaccacg accaggacaa tactggaggg cagcatcagc agttttggtg gcgggacaaa 240 tgagcctctg gcgagcaaaa tacccgttct ggaggagtca gcctcacatg ccagatattt 300 gaaattcatt gccgacgggc tcatcgacga gggactgggc agtgcggtgg gcagtgggag 360 cagcatcgcc gtatccgttg aagacgtggt cgccggacag gcgcaggaca tccaggcgag 420 cgaaggatcc accgacgacg ccgacggcag tagccatttg gcattagtct tcgtcaagtg 480 tttcattatt ggtttcatca tactggccgc catcctgggc aacatgctgg tgattgtgtc 540 ggtcatgcgg caccggaaat tgcgcatcat taccaactac tttgtggtct ctctggccgt 600 cgccgacatg ctggtggccc tctgtgcgat gacatttaat gcttccgtca tgatctcggg 660 caagtggatg tttggttccg tgatgtgcga catgtggaac agcttcgacg tctacttctc 720 caccgccagc atcatgcacc tctgttgcat atcggtcgac agatactacg ccattgtgca 780 gccactggac tatccactaa tcatgacaca gcgacgcgtg ttcatcatgc tattgatggt 840 gtggctatcg ccggcgctcc tctcgttcct gcccatctgc tcgggatggt acacaacgac 900 cgagaactac aagtatctca aatcgaatcc gcatatatgc gagttcaaag tgaacaaggc 960 atacgccata gtcagctcgt cgatgagctt ctggattccc ggcatcgtaa tgctgtcgat 1020 gtactaccgc atttaccagg aggccgaccg acaggagcgt ctggtgtaca gatccaaggt 1080 ggccgctctg ctgctggaga agcatctgca aattagccaa attcccaagc cccggccgag 1140 cattcaggtg gagcagtcga ccatctcgac gatgcggcgt gagcggaagg ccgcccgcac 1200 cctgggcatc atcatgagcg ccttcctcat ctgctggctg ccgttcttcc tctggtacat 1260 cgtatcctcg ctgtgcgata gttgcatcac tccgcgcctg ctcgttggca tcctgttttg 1320 gatcggctac ttcaactcgg ccctgaaccc cattatttat gcatacttca accgcgactt 1380 cagggccgcc ttcaagaaga ccctcaagag tctgtttccc tacgctttct acttctgtcg 1440 acgtggcagg gggcgagacg atgaccggga tctggagttc ggcggtccca gccgacgggg 1500 aaccaatgga gcccaacgga ccggatccgg atccgccgag atggccaact gcgtcaactc 1560 cacggcctcg tcggagatac acatgagcgt gatgcgtgcc cgccagtatg ccgtcaatgt 1620 cacacccacc acggacgccc agatgcagca gctgcatccc ctgtacacca actaa 1675

<210> 69 <211> 508 <212> PRT <213> Drosophila

<400> 69

Met Thr Leu Leu Gin Arg Leu Gin Ala Met Ser Ala Thr Thr Thr Arg

1 5 10 15

Thr He Leu Glu Gly Ser He Ser Ser Phe Gly Gly Gly Thr Asn Glu

20 25 30

Pro Leu Ala Ser Lys He Pro Val Leu Glu Glu Ser Ala Ser His Ala

35 40 45

Arg Tyr Leu Lys Phe He Ala Asp Gly Leu He Asp Glu Gly Leu Gly

50 55 60

Ser Ala Val Gly Ser Gly Ser Ser He Ala Val Ser Val Glu Asp Val 65 70 75 80

Val Ala Gly Gin Ala Gin Asp He Gin Ala Ser Glu Gly Ser Thr Asp

85 90 95

Asp Ala Asp Gly Ser Ser His Leu Ala Leu Val Phe Val Lys Cys Phe

100 105 110

He He Gly Phe He He Leu Ala Ala He Leu Gly Asn Met Leu Val

100 115 120 125

He Val Ser Val Met Arg His Arg Lys Leu Arg He He Thr Asn Tyr

130 135 140

Phe Val Val Ser Leu Ala Val Ala Asp Met Leu Val Ala Leu Cys Ala 145 150 155 160

Met Thr Phe Asn Ala Ser Val Met He Ser Gly Lys Trp Met Phe Gly

165 170 175

Ser Val Met Cys Asp Met Trp Asn Ser Phe Asp Val Tyr Phe Ser Thr

180 185 190

Ala Ser He Met His Leu Cys Cys He Ser Val Asp Arg Tyr Tyr Ala

195 200 205

He Val Gin Pro Leu Asp Tyr Pro Leu He Met Thr Gin Arg Arg Val

210 215 220

Phe He Met Leu Leu Met Val Trp Leu Ser Pro Ala Leu Leu Ser Phe 225 230 235 240

Leu Pro He Cys Ser Gly Trp Tyr Thr Thr Thr Glu Asn Tyr Lys Tyr

245 250 255

Leu Lys Ser Asn Pro His He Cys Glu Phe Lys Val Asn Lys Ala Tyr

260 265 270

Ala He Val Ser Ser Ser Met Ser Phe Trp He Pro Gly He Val Met

275 280 285

Leu Ser Met Tyr Tyr Arg He Tyr Gin Glu Ala Asp Arg Gin Glu Arg

290 295 300

Leu Val Tyr Arg Ser Lys Val Ala Ala Leu Leu Leu Glu Lys His Leu 305 310 315 320

Gin He Ser Gin He Pro Lys Pro Arg Pro Ser He Gin Val Glu Gin

325 330 335

Ser Thr He Ser Thr Met Arg Arg Glu Arg Lys Ala Ala Arg Thr Leu

340 345 350

Gly He He Met Ser Ala Phe Leu He Cys Trp Leu Pro Phe Phe Leu

355 360 365

Trp Tyr He Val Ser Ser Leu Cys Asp Ser Cys He Thr Pro Arg Leu

370 375 380

Leu Val Gly He Leu Phe Trp He Gly Tyr Phe Asn Ser Ala Leu Asn 385 390 395 400

Pro He He Tyr Ala Tyr Phe Asn Arg Asp Phe Arg Ala Ala Phe Lys

405 410 415

Lys Thr Leu Lys Ser Leu Phe Pro Tyr Ala Phe Tyr Phe Cys Arg Arg

420 425 430

Gly Arg Gly Arg Asp Asp Asp Arg Asp Leu Glu Phe Gly Gly Pro Ser

435 440 445

Arg Arg Gly Thr Asn Gly Ala Gin Arg Thr Gly Ser Gly Ser Ala Glu

450 455 460

Met Ala Asn Cys Val Asn Ser Thr Ala Ser Ser Glu He His Met Ser 465 470 475 480

Val Met Arg Ala Arg Gin Tyr Ala Val Asn Val Thr Pro Thr Thr Asp

485 490 495

Ala Gin Met Gin Gin Leu His Pro Leu Tyr Thr Asn 500 505

<210> 70 <211> 3651 <212> DNA <213> Drosophila

<400> 70 ctggacgccg gacacgaaag cagatcacct gccgtacagt gccaagatca tcgaacgcat 60 ttacaatgag gagatcggtg atggcggtgg ccacagtgca cggaggataa acatgctgga 120 gttcagtcag tatctggagc agtacctgtg gccacactac caacgtgaaa ccgccaccca 180

101 tgcccacctt atgtccatcg ttataatggc caacgagaag ttccgggagc gcgtcgaagt 240 ttggaccgtg tttgaaaagc tcccggatca gtatccagcc ttctttcgcc acgtgctaga 300 gagctgtttg ccgagcaaaa aggcaaagga ggctagtagc acgctaaggg agcggacagc 360 gctgttgatg ttcattaacc actgctttaa cagcatggag atagagctgt gcagagaaca 420 ggccaaacga ctagtctcct tgtccatgtg gcattgcctg cagcctcgta agttcttctt 480 cgcaactctt cacatctatc aaagtgatca aaaatgtatt tgcttgcagg ccgtcgcgaa 540 caagagcttc gagaagttcc tgagtggcga aagtactgga aacgcttgct caagaaggag 600 aaagacagca aaccggaggt cctctgggag agacacttta tgcagaacct tatcattgac 660 ttcctgcaca tactcgaaag cattcccgcc gaaggcgagg tgccgcgcaa cgtggttcac 720 tactgtgagc gcttcctaga gtttattatc gacttggagg cacttttgcc gactcgacgc 780 ttcttcaaca cggttttaga cgactgtcat ctgattgtgc gggctcttct gtcacccttg 840 gttcgtcgcg aggagggaaa actgtttggt caggtaggtg tcagacttct catttaataa 900 ctatctcgta cagcataaat tagttaaaat taagtacaaa tctcaatgtt ggacattgct 960 aaactacgaa aacacttata ttagtgtgga cggtggctcc tcagtaatcg ttgccgttca 1020 tataatgcag ctcatcgccc cagtcgtttg ccgacggtgg ctcattgtag cagcaggtct 1080 ttttcagcag aaatgtcaca tgtcgctggc gcagcacgca tatgtatagc aacagcggcg 1140 tctgcagggc gttaactacg atgtgggcgt aaagcaggcc ttccatctgc aaccaggaca 1200 ttatgaggaa tagccaggct atagacatta ctaacagcat cagcgagaac atgataaaac 1260 tgcaaggaag ataatgtttt catatactta tatgtaatgc ctagatgccg atctacttac 1320 ttggctttca atttgtgcgc aatgcggccg tataccgtcc tgcggttaat caacttcctg 1380 gtggtcacat agaagaatat gtttaccaaa atggtacaag caattggagc aaagaatatg 1440 catatgccta gccagccgat cgtctcttgc tcgcccacca tgtgctcctg tttgtaggat 1500 tcggcgtcga ggaagaaatg tgcgaagaca gccagtgcag ccatcgttgc tgtgcatccc 1560 caagcatacg cagaataata gcagtacttc ctgccgtccg tgactcgcag gaagacgttc 1620 ctcgaacgaa aggtcttcca aatgtaaaaa ccgaaactgt tcagccagaa gaaagctgcc 1680 aagaggctga agcacaggat aatgtccgcc acaatgaagc tcacatggct ggtcagctcg 1740 gtgaaaattc tgacaaggtc tgctgcctgg cttaccataa ggcacatggc tatcgttgtc 1800 acaatgttac caaccagatc tctgctgaat ggattgaaaa ttaacgcatg aagcaagtca 1860 aattcaaact attgctcacc tgagagtagg aagtataaaa tagatgatgg cgatgaccag 1920 caggataaca agcgagatgc catggaaaat tgggtttaag attttgcgga gcagaaagtt 1980 tgagtcactc cacttgatct ccttgcgggc caagcaaatg ttggcgaata gcacattttc 2040 ctctccagta ctggaagtgg cctgcgaatg gattttatga tcatccatgc aatttatgtg 2100 gactttagct actcttacct tgtcaatgca atacaatccc ttatcgtagt catggtatag 2160 cggttccaga ctgccggcaa tatcctcctc ataatccgat tgtattccat gacgctcctc 2220 tgcttcgttt tcggcattgg tgtaatgcct tagcctccca tcatccagta acactagctt 2280 atcagagctc tagaaaatat aaaaatatct ataagtatct aaaagtttct atgcaaagaa 2340 cttcaaactc acgccagcat agtggtatat tggccacatc tgcatggatc cacaatttgg 2400 aatcccgatg acgaatttga acttaacggg cctgttttgc tctcctccat agctggtgaa 2460 catcggctgg aagtagtctg caaatggaaa cggacgataa atagagaaca cagaccgtgg 2520 aaaatcataa aggcagttca agttaacgct gcttttgttg cggctggtgg atcagagggg 2580 agccagattt tcttttctct ctgcgaatat aaatatttac gcttctgggc aaagaacttg 2640 agctgttcca tgcgccttca tcagctggtt ttgcaatttg tgcagattgg ttcttcttca 2700 attatcggag ttcggataca tttttttcca ctcagccatt catatgttaa tcatagctaa 2760 gcacacggaa attagattgc atgttgcgat tatgtgccct gttgtattgt agtattggga 2820 ttactcaaat gactacaatt aaaatcggat gagatcagta caatgcaatg attcaactat 2880 cagtaatagt tacattttta tgtgtcacct atatggccga tccatggtca taaatgtttt 2940 atccagtttt agttgtccga gctagaatat cgatatagat gctagagtac gcttttctat 3000 ttcccacaat tgttgcgatt gtttgtcaaa cattcaccca aggcaatata tcactatatt 3060 caccattagc tccacaaaca ttaattacca gggctcgcat ttatggggaa cagaagcatc 3120 ttatattacc ttactaatgg attttttgcc tcattttact tccaagagat aatattcccg 3180 atttgggaat ccctcatcaa gtggctactt tatagtttaa acagaaacat gccccacagc 3240 ataaatcata tttctcatca ggattggggc caccctctgt ttgttttaag aactttcttg 3300 ggggagtgcg aactgtggag ttggggatat ttagctgttg gcttcgttcc actgatccac 3360 tgatagccaa caaatgggcc atttaatgtt gggcatacat atgttgcatg ccagaaggga 3420 aaatccataa agttgaatgg ccaaccaact tcgttgtggt tgttatggca actttttcga 3480 gcgactagga gttttccgcc tggccagctg ttgaacttac ccgtttcatt gacctgctga 3540 cactcatggt ccacgtgtat ctcgaacttc tcgcaacatt tgttgaccag cactaggttg 3600 ggatcggaag atagggctgt tgatgatccg gcgctagtga catgactggt t 3651

<210> 71

102 <211> 1272

<212> DNA

<213> Drosophila

<400> 71 atggaacagc tcaagttctt tgcccagaag cactacttcc agccgatgtt caccagctat 60 ggaggagagc aaaacaggcc cgttaagttc aaattcgtca tcgggattcc aaattgtgga 120 tccatgcaga tgtggccaat ataccactat gctggcagct ctgataagct agtgttactg 180 gatgatggga ggctaaggca ttacaccaat gccgaaaacg aagcagagga gcgtcatgga 240 atacaatcgg attatgagga ggatattgcc ggcagtctgg aaccgctata ccatgactac 300 gataagggat tgtattgcat tgacaaggcc acttccagta ctggagagga aaatgtgcta 360 ttcgccaaca tttgcttggc ccgcaaggag atcaagtgga gtgactcaaa ctttctgctc 420 cgcaaaatct taaacccaat tttccatggc atctcgcttg ttatcctgct ggtcatcgcc 480 atcatctatt ttatacttcc tactctcagc agagatctgg ttggtaacat tgtgacaacg 540 atagccatgt gccttatggt aagccaggca gcagaccttg tcagaatttt caccgagctg 600 accagccatg tgagcttcat tgtggcggac attatcctgt gcttcagcct cttggcagct 660 ttcttctggc tgaacagttt cggtttttac atttggaaga cctttcgttc gaggaacgtc 720 ttcctgcgag tcacggacgg caggaagtac tgctattatt ctgcgtatgc ttggggatgc 780 acagcaacga tggctgcact ggctgtcttc gcacatttct tcctcgacgc cgaatcctac 840 aaacaggagc acatggtggg cgagcaagag acgatcggct ggctaggcat atgcatattc 900 tttgctccaa ttgcttgtac cattttggta aacatattct tctatgtgac caccaggaag 960 ttgattaacc gcaggacggt atacggccgc attgcgcaca aattgaaagc caattttatc 1020 atgttctcgc tgatgctgtt agtaatgtct atagcctggc tattcctcat aatgtcctgg 1080 ttgcagatgg aaggcctgct ttacgcccac atcgtagtta acgccctgca gacgccgctg 1140 ttgctataca tatgcgtgct gcgccagcga catgtgacat ttctgctgaa aaagacctgc 1200 tgctacaatg agccaccgtc ggcaaacgac tggggcgatg agctgcatta tatgaacggc 1260 aacgattact ga 1272

<210> 72 <211> 423 <212> PRT <213> Drosophila

<400> 72

Met Glu Gin Leu Lys Phe Phe Ala Gin Lys His Tyr Phe Gin Pro Met

1 5 10 15

Phe Thr Ser Tyr Gly Gly Glu Gin Asn Arg Pro Val Lys Phe Lys Phe 20 25 30

Val He Gly He Pro Asn Cys Gly Ser Met Gin Met Trp Pro He Tyr 35 40 45

His Tyr Ala Gly Ser Ser Asp Lys Leu Val Leu Leu Asp Asp Gly Arg 50 55 60

Leu Arg His Tyr Thr Asn Ala Glu Asn Glu Ala Glu Glu Arg His Gly 65 70 75 80

He Gin Ser Asp Tyr Glu Glu Asp He Ala Gly Ser Leu Glu Pro Leu 85 90 95

Tyr His Asp Tyr Asp Lys Gly Leu Tyr Cys He Asp Lys Ala Thr Ser 100 105 110

Ser Thr Gly Glu Glu Asn Val Leu Phe Ala Asn He Cys Leu Ala Arg 115 120 125

Lys Glu He Lys Trp Ser Asp Ser Asn Phe Leu Leu Arg Lys He Leu 130 135 140

Asn Pro He Phe His Gly He Ser Leu Val He Leu Leu Val He Ala

145 150 155 160

He He Tyr Phe He Leu Pro Thr Leu Ser Arg Asp Leu Val Gly Asn 165 170 175

He Val Thr Thr He Ala Met Cys Leu Met Val Ser Gin Ala Ala Asp 180 185 190

Leu Val Arg He Phe Thr Glu Leu Thr Ser His Val Ser Phe He Val 195 200 205

103 Ala Asp He He Leu Cys Phe Ser Leu Leu Ala Ala Phe Phe Trp Leu

210 215 220

Asn Ser Phe Gly Phe Tyr He Trp Lys Thr Phe Arg Ser Arg Asn Val 225 230 235 240

Phe Leu Arg Val Thr Asp Gly Arg Lys Tyr Cys Tyr Tyr Ser Ala Tyr

245 250 255

Ala Trp Gly Cys Thr Ala Thr Met Ala Ala Leu Ala Val Phe Ala His

260 265 270

Phe Phe Leu Asp Ala Glu Ser Tyr Lys Gin Glu His Met Val Gly Glu

275 280 285

Gin Glu Thr He Gly Trp Leu Gly He Cys He Phe Phe Ala Pro He

290 295 300

Ala Cys Thr He Leu Val Asn He Phe Phe Tyr Val Thr Thr Arg Lys 305 310 315 320

Leu He Asn Arg Arg Thr Val Tyr Gly Arg He Ala His Lys Leu Lys

325 330 335

Ala Asn Phe He Met Phe Ser Leu Met Leu Leu Val Met Ser He Ala

340 345 350

Trp Leu Phe Leu He Met Ser Trp Leu Gin Met Glu Gly Leu Leu Tyr

355 360 365

Ala His He Val Val Asn Ala Leu Gin Thr Pro Leu Leu Leu Tyr He

370 375 380

Cys Val Leu Arg Gin Arg His Val Thr Phe Leu Leu Lys Lys Thr Cys 385 390 395 400

Cys Tyr Asn Glu Pro Pro Ser Ala Asn Asp Trp Gly Asp Glu Leu His

405 410 415

Tyr Met Asn Gly Asn Asp Tyr 420

<210> 73 <211> 5299 <212> DNA <213> Drosophila

<400> 73 gctgttcgca cggcattttt gggccagcaa acaggatgcg gaaaaccgga agctgggaac 60 tggaaatggg caagaatctg gtttttggct gccattcaat taggtatcgg tcagcccaat 120 tcaactgctg ctaactggca actggagatt tggcgattgc agctgcccat tgtcaacact 180 tcaattaacg caatagcagg taaaaagggg acatcttttc atcgagatct cgaccttgtt 240 ttgctatcct tgcaaacaat tgatggtatg tcgtaagttt gtgcgaataa aatggttttg 300 gaaatatata tatatattgt ttattagttt atggccccaa aaaatgctac aacacaatat 360 tgaaaccgtt gttatctgaa gggaatgcaa cgattcgagc ttcatattga gaaggtcctg 420 ttttctctct gttcctgcat agttcctctt tcatttcgca tctttttcca ctggccgcag 480 tctcgcagga tatgctaact aaggactatg ccaccatatt cgacaatttg ttgggcacca 540 agttaatatg cattgatgcg ttattcatac gccccgtggg acgggcgaat agcaaaactc 600 tcaatgggcc tttgttaatt tgtatgtgtg tgtatgtgta ttttgcgtgt atttgatttg 660 atgcgtttag tacttaggat aacaattacg tttaggttaa ctagcataaa tctataatca 720 tcacattatg gcacaatgta tgttatgtag tatatatata tcgtatatat agagagactg 780 atatacatag atatcgattg atataacaaa ttaaattttc agctaaccgc acgcttcaac 840 tgaatcactt ttgattcaat catctcactt gtgattccgc gtgatttgct ggcaaattta 900 aagccctctt ctcgtgtttc atgagaagtt tcatgatatc atctatcact cctctcatgg 960 agtttaaaac cataaatatt ttattataaa tattcactat tcacgctatc aggcgacccg 1020 tattacgatt tcgacgactt ccggctccgc cataattact accataatga tcgccattta 1080 tttgggtcag tgtagtcgtt gtatgcggca catagagact cgtattgtta cgcgcatgtc 1140 gacgtctata gcgatatccc gttatcagtt ctcgaaccgt ctttcggtac ttatcggaaa 1200 gtacacagta tagaaaaaaa ttggatgccg catgtaggga ggccaatagg ttacacacat 1260 ttcccgccac cacctgagtg ccaatttgaa tttccatata ctgattgact atcaaataga 1320 tcgcccaagg caattggcaa actatgaaca ttaacaccac cgcaataagt gtgatcgtca 1380 cgcgattttc ctgcgatacg ctgcctttta gtccagaatt tgatttgcgc taaggattca 1440

104 gaatttatac aacatatcat catcatcatc atcgtttcga ataactcact tttgtgcgcc 1500 ttatgctgct ggcattggtc aggtcaccac gcagattctt ggaccgatga accaatagaa 1560 tgagaatgga gttgaaggtg gccaatagaa gtagggggaa taccacgaag accagcaggg 1620 tgaacaggtt ccacagatag ctgtatagct catcatagcc cagttccgaa agaccatgat 1680 tgtaataggt cacctaaaac atatagatag atacatagaa tacatacata gatttccatt 1740 aagaacaacc ttttaagcaa tggaatatcc caagcgacta agtaaaagca tgtcttacaa 1800 aacccaaagc actgatatca ttttaagtta tcaccgaatt tatcatagtc atggcgcttg 1860 tacaccgctc gtgattttca ctggttaaca attttctcat gtttttttct ccagggaaat 1920 cgacggtatt tccaacatta ttttactcac attttgacag tattccgtta cgttaaatgc 1980 gaatgcatcc gtattgttga tgttgtgatt ctcagcgctg cgcttgcgac gccacaattg 2040 cagcaaactc tctgtgaccc ctgacctctg ggccgcgtct gccaccttct gatcctgctc 2100 ctccagcgtt tttctcagtg tgggcagcgt cacaaatcca gatgactgcc agtgacggcg 2160 atgtcgtgga atgttctcta gttgagggca aagaaagtaa tgcaactatc aactacttca 2220 cttataaagc tgtctaaaag tatgcttcgt acttttcaat gcatacttct aagcatctct 2280 attaatacaa cttcgatttt tccaagtgta cactactgct ataccctcgt tactcacctg 2340 gctctccatc accactgcca ctgccccagt cgacgagctg attagagctg ccggacgtcg 2400 tggactccat ggcggagtcc ggcgattgcc aaatggtcgc cggcgtgggc agcgggggcg 2460 tggccagtgg gggcgtgact gccacgggtg gcggcggcat gggcgagatg ttggccaccg 2520 tttggttgca cggctggtag gcgtcatcaa tctgcctagt accaatcgta attgtatgct 2580 cgaatgccgt cgatagtgtg gacagcaaac agaagatggc caccgctggc aatgtagaat 2640 ataaagttgc atatggaaat ggattctatt gttacatacg cctatttcag ccaactcacc 2700 tgctatcacc tttttggcca gcgattccgt gcagaatgtt tgcctcttga gcggatagcg 2760 tatcgcaatg aatctctcga tggtgaagca cacggctatg taaattgaga tgtaacctgt 2820 ccggtaaaaa cagagaaagc aattgtgaat gggggcgtgg cagtacaata cgaacgcaat 2880 caaagatgca ctgcaaatat tttgggaaaa tccaatccaa aaaggatata tatacatata 2940 tatttattca ggttaagtgt ctaatataga ttggtaaatt aaattcaaac ttcggttaga 3000 ctgtgccttt tttccgtgta ctctggaatt ataaataaac gcagctccgc tgttaatacc 3060 ccaaaccatc catttttgac cgcaccacca atttatttgc cgcgcgggct gtcaatttat 3120 tcaaaacgca gcgcactcta agcgattgac gtccgtgctg tgctgatgag gttgctgcgg 3180 gagggtggga tattcaaggg gggtgagggg ggtgaaaagt ggggtgggaa agcggaaaac 3240 ggttcggaaa aacgctatcg catggcagtg agcctcagct gaccgctggc atttcgcaga 3300 aagcgctgct tactatacct cgtaaattgg cagagctcaa tgaaattgat gcacaacaga 3360 aacagcagca gcagcagcag cagcagcagc agcagcagca acagccgcag gtgcaattcg 3420 aattgatggg cccatcgctg gaatccggtt gatacggggg gaaatggggg atacattgga 3480 tccggggatc cagacgaggc taacccgggg aactggggaa tttatggaat ccgcaccatt 3540 ccacttagtg ctctccaaac gttgcattcg aactgttttt gttttttgcc cccggcagca 3600 attgttttca ccgcatgata tgtacgcttt tcttattgta gttttgcggg aataatgtta 3660 aatataaaaa cacccttttg gtaaattttt tcaaattgaa agcttattta agcataaaat 3720 actcgtgttt cgatttaaag aacactaatc gagttacttt cggtctcaca accttattta 3780 ttgcatactt tgcgactgct ttgaattatt gaattattac tccattgcta cttaattcta 3840 atttggtcag tactcaccga aactgtcgca cagccagaca aaatagccat agagctgcca 3900 gtagagcttg aaatgatact tgggatagtc atagtgctgg agtgacagga ttaactggca 3960 cgtcaggtag gcaatatccg taatggccag tgccgttaga tatatgttcg tcgtgcatct 4020 catgcgcttt ctaaaaatac cgtcaagaat atcgaaaaga attgcaaatg gtgttgattc 4080 tgttgggcac tcgacgcatt tggaaatcag gccaaaccat ttcggtggac aatgcaaaaa 4140 cgctgccaag tgcaacacca attgaaatag caaattgcct gaaagccaaa cgatcggtgg 4200 ggttgtgcgc agagggggtg gaaaattcca ggcggttgat gtgatgggcg cggggccttg 4260 ggcattttcc gaaatgcgca caaatgtcgg cacagtcata aagccaaaag atgaacaata 4320 aaaactaact gttagcattt agttttctcc ctggcatcgc ccgcagctct gatagttaaa 4380 ttctcttgta ttcccgtaaa acaaaataaa ataacgtaat gaaaatattt aattaaaaag 4440 ccattcatgc cgtcaacgct caatgttaag ctagttgctt tgaaaagttg taaatatggt 4500 ttaaaataat aaagttcatg ctataaatat caataaattt tgtttagcaa ataaatgaat 4560 ttgctaagat cttagcaagg aacacagttt atcttttttt ttcacgtttt cctgggaaat 4620 ggacatatgg tgtcatagca gtcagcctaa cgcacagagc acttgcaact gtcgcatatt 4680 ttccggcaga cataaaaaac acacccatcc acacagcata tcgcctatct gtgtgcgttt 4740 ttgcatttgg cacataaaat ggctcttatt gtttcagtta ctgttattgt tgttgcactt 4800 gtacccaacg tagttgttgc tgttgttatt gttatcgttg ttggctgtgt ggaaatgatt 4860 ttaaagtgca gcggtggcta caattaaatg tcgtgtttaa tgcgctgcgt acctgctcgc 4920 cgcttcatcc atgttccact tatttcacac acacagacac acacacacac gcacaacagg 4980 acatgcagtt ggatgcacag agagaaaatc gtgcaagtta gctggcattt taaatggaaa 5040

105 attgtaactt aaaactagtt taaaacaagc tcaaacgaat aagttgaagt ttggaataaa 5100 attaatttga aaaggctcat atattttata tgcattgcat actttttagt acttaaccaa 5160 atgcatgaaa atccaattag tcgcttttgc atacctaata acttaacatt cttaacgtgg 5220 cagctaaaac ttctttcaaa tgccatcatc agctaaatga ttcatattta attcgaaaat 5280 cttgtgaccc tgctgcatg 5299

<210> 74 <211> 1467 <212> DNA <213> Drosophila

<400> 74 atgactgtgc cgacatttgt gcgcatttcg gaaaatgccc aaggccccgc gcccatcaca 60 tcaaccgcct ggaattttcc accccctctg cgcacaaccc caccgatcgt ttggctttca 120 ggcaatttgc tatttcaatt ggtgttgcac ttggcagcgt ttttgcattg tccaccgaaa 180 tggtttggcc tgatttccaa atgcgtcgag tgcccaacag aatcaacacc atttgcaatt 240 cttttcgata ttcttgacgg tatttttaga aagcgcatga gatgcacgac gaacatatat 300 ctaacggcac tggccattac ggatattgcc tacctgacgt gccagttaat cctgtcactc 360 cagcactatg actatcccaa gtatcatttc aagctctact ggcagctcta tggctatttt 420 gtctggctgt gcgacagttt cggttacatc tcaatttaca tagccgtgtg cttcaccatc 480 gagagattca ttgcgatacg ctatccgctc aagaggcaaa cattctgcac ggaatcgctg 540 gccaaaaagg tgatagcagc ggtggccatc ttctgtttgc tgtccacact atcgacggca 600 ttcgagcata caattacgat tggtactagg cagattgatg acgcctacca gccgtgcaac 660 caaacggtgg ccaacatctc gcccatgccg ccgccacccg tggcagtcac gcccccactg 720 gccacgcccc cgctgcccac gccggcgacc atttggcaat cgccggactc cgccatggag 780 tccacgacgt ccggcagctc taatcagctc gtcgactggg gcagtggcag tggtgatgga 840 gagccagaga acattccacg acatcgccgt cactggcagt catctggatt tgtgacgctg 900 cccacactga gaaaaacgct ggaggagcag gatcagaagg tggcagacgc ggcccagagg 960 tcaggggtca cagagagttt gctgcaattg tggcgtcgca agcgcagcgc tgagaatcac 1020 aacatcaaca atacggatgc attcgcattt aacgtaacgg aatactgtca aaatgtgacc 1080 tattacaatc atggtctttc ggaactgggc tatgatgagc tatacagcta tctgtggaac 1140 ctgttcaccc tgctggtctt cgtggtattc cccctacttc tattggccac cttcaactcc 1200 attctcattc tattggttca tcggtccaag aatctgcgtg gtgacctgac caatgccagc 1260 agcataaggc gcacaaaata ccgaaagacg gttcgagaac tgataacggg atatcgctat 1320 agacgtcgac atgcgcgtaa caatacgagt ctctatgtgc cgcatacaac gactacactg 1380 acccaaataa atggcgatca ttatggtagt aattatggcg gagccggaag tcgtcgaaat 1440 cgtaatacgg gtcgcctgat agcgtga 1467

<210> 75 <211> 488 <212> PRT <213> Drosophila

<400> 75

Met Thr Val Pro Thr Phe Val Arg He Ser Glu Asn Ala Gin Gly Pro

1 5 10 15

Ala Pro He Thr Ser Thr Ala Trp Asn Phe Pro Pro Pro Leu Arg Thr

20 25 30

Thr Pro Pro He Val Trp Leu Ser Gly Asn Leu Leu Phe Gin Leu Val

35 40 45

Leu His Leu Ala Ala Phe Leu His Cys Pro Pro Lys Trp Phe Gly Leu

50 55 60

He Ser Lys Cys Val Glu Cys Pro Thr Glu Ser Thr Pro Phe Ala He 65 70 75 80

Leu Phe Asp He Leu Asp Gly He Phe Arg Lys Arg Met Arg Cys Thr

85 90 95

Thr Asn He Tyr Leu Thr Ala Leu Ala He Thr Asp He Ala Tyr Leu 100 105 110

106 Thr Cys Gin Leu He Leu Ser Leu Gin His Tyr Asp Tyr Pro Lys Tyr

115 120 125

His Phe Lys Leu Tyr Trp Gin Leu Tyr Gly Tyr Phe Val Trp Leu Cys

130 135 140

Asp Ser Phe Gly Tyr He Ser He Tyr He Ala Val Cys Phe Thr He 145 150 155 160

Glu Arg Phe He Ala He Arg Tyr Pro Leu Lys Arg Gin Thr Phe Cys

165 170 175

Thr Glu Ser Leu Ala Lys Lys Val He Ala Ala Val Ala He Phe Cys

180 185 190

Leu Leu Ser Thr Leu Ser Thr Ala Phe Glu His Thr He Thr He Gly

195 200 205

Thr Arg Gin He Asp Asp Ala Tyr Gin Pro Cys Asn Gin Thr Val Ala

210 215 220

Asn He Ser Pro Met Pro Pro Pro Pro Val Ala Val Thr Pro Pro Leu 225 230 235 240

Ala Thr Pro Pro Leu Pro Thr Pro Ala Thr He Trp Gin Ser Pro Asp

245 250 255

Ser Ala Met Glu Ser Thr Thr Ser Gly Ser Ser Asn Gin Leu Val Asp

260 265 270

Trp Gly Ser Gly Ser Gly Asp Gly Glu Pro Glu Asn He Pro Arg His

275 280 285

Arg Arg His Trp Gin Ser Ser Gly Phe Val Thr Leu Pro Thr Leu Arg

290 295 300

Lys Thr Leu Glu Glu Gin Asp Gin Lys Val Ala Asp Ala Ala Gin Arg 305 310 315 320

Ser Gly Val Thr Glu Ser Leu Leu Gin Leu Trp Arg Arg Lys Arg Ser

325 330 335

Ala Glu Asn His Asn He Asn Asn Thr Asp Ala Phe Ala Phe Asn Val

340 345 350

Thr Glu Tyr Cys Gin Asn Val Thr Tyr Tyr Asn His Gly Leu Ser Glu

355 360 365

Leu Gly Tyr Asp Glu Leu Tyr Ser Tyr Leu Trp Asn Leu Phe Thr Leu

370 375 380

Leu Val Phe Val Val Phe Pro Leu Leu Leu Leu Ala Thr Phe Asn Ser 385 390 395 400

He Leu He Leu Leu Val His Arg Ser Lys Asn Leu Arg Gly Asp Leu

405 410 415

Thr Asn Ala Ser Ser He Arg Arg Thr Lys Tyr Arg Lys Thr Val Arg

420 425 430

Glu Leu He Thr Gly Tyr Arg Tyr Arg Arg Arg His Ala Arg Asn Asn

435 440 445

Thr Ser Leu Tyr Val Pro His Thr Thr Thr Thr Leu Thr Gin He Asn

450 455 460

Gly Asp His Tyr Gly Ser Asn Tyr Gly Gly Ala Gly Ser Arg Arg Asn 465 470 475 480

Arg Asn Thr Gly Arg Leu He Ala 485

<210> 76 <211> 3946 <212> DNA <213> Drosophila

<400> 76 ataaatggcc gaatttgcaa gtcagttcca cttgctcttt aaaaagcgaa tctcaccgaa 60 atttaagcaa aatttatcac cgaccaatgt gaaattccac taataatttt tcagcggtgt 120 tgatggcttt attgacatcg ccagaaatga ttcgagctgt agcagcgaaa atttaatcaa 180 agacctaacc cacgaacctg gacgttctca catagaaaat gaaaacgaaa gctgaaagac 240

107 agatggatcg ttcgatgtga gctcttttta cacttggctt acacgacgac tgcggcgtcg 300 gtaaaattaa tataccaaac aattacacgg cccggcaaaa caattttaag cccagttaat 360 gccgtcgcac agtggctgca agccacgcaa attcgccgcg aaaaattgcc cacaattgcc 420 agtggccgag aaatgaaagc gctcaaattt gcatactcgt actgtcaaat gaagcgtagc 480 aaaaggaaaa ttgctacaca tactaattgg aaaagaaatg caaaaccaat gcaaatgaaa 540 ataatgacag ggcgcggttt gcgaagctgt ctaattattt atttgacatt ggcaatgaca 600 atgaaaccga gagtcccaca gcagagtaat ggatttttct ttcaactgct taagttcgtt 660 ttccattgaa atcttatttg gacatataaa ccatacgtag aatgataaga ataataaaaa 720 acaagtatgt tggacacaat tgataaggaa tctttagtac tttctcacct aaaaaaggtg 780 atatatattt gaattcatgt tgtcatgata gctactcgaa ccactgtgcg ttggctacag 840 tctgctgatg ctcacagtgt ttgaaagtta agacttttgc tttccttccc ccgacttggt 900 ttttgctttt ggaaagacca agcaaatgga taaacaagag ttcaagaggt tgtcagcccc 960 gcccctttgc gcacatgagg caagaaagaa aagaaagtta ttacaaaatt aacagaggct 1020 gacagctgac aagggcagag gaatggggcc gaaatggaac tgtatctagc ttgagttggg 1080 tccgaccgcc tcgggcagaa aatgtgacaa atttggaggg gaaaagctcg tatgagcggg 1140 acttaccacc tccattgttg gcactggagc agtgtttgga gctgagtccc tggcccgtgt 1200 tggatgcaga gttgggcagt ccgcagccgc tcatcacgcc gtacttgatg ggcttgaagt 1260 ggaagaacga gggcgagtag ccggaaccgg cgcgactcag ggaactgaac tgctcctcgc 1320 ggtcctccac gtacaggccc tccttgccca tggccgccag ttgcctgccc ttgggcatga 1380 acatcaccaa gaagaccgtg gcggatgtgg ctaccagacc gaaggccacg caagcgtcct 1440 tgtgccgctc ggccacggcc aggccgcata gcatccatcc cagccagatg gggatggctc 1500 ctccgatggc cagcccaatg taggtggcct cacggtagtt gtccctgatg ccgcgcgact 1560 tgatggctag cacggcgatg aagacgatca gaaagacaat gtagatcagc gagaagagca 1620 gctccgagaa ctgcgtcttg cagagcggta ttagtacggt gctaaccgcc gctatccggg 1680 tgtagatctc cggagtcccg tccagcgttg tgtaggacgt ggggtaaaac agtgccgagt 1740 agttggtctg tgaggccacc gtggtgctaa ggaagccact gcccatcaca ggcacactgg 1800 tggtgtatac ctccggtggt tgggtgagca gccactgccc tccgatcgct acctggatga 1860 gcagcgcaaa gaggagcagc aatccctggt atggagccgg cagatacacc cctccattta 1920 gactaatcag aaatacgcat ttgaccagca gggcggcaaa gaccagggcg taggccacgc 1980 ccactccgaa gcggatggcc ccgcaactga tcaacgaggg ctgtgcggtg atgatggccc 2040 ccaaactagc gcaggcgaac agaccgagaa gcagcatctg gcccagaaag aggtgcctac 2100 gcgacgggga cgtccgccag gccttgaaga gcacaaagat ctcgaacgct gccatcatga 2160 gcatggtgag ggtggccagg actagcaccg gcaccaccca cggctccttg cgtagtcccg 2220 cgaagggcaa gtgggtggac actatactgg gcggtgtgct gttggagctg ctcccgggag 2280 tcacccgtcc agtggtgccg gctgctcgcg ccttcgcccc tgaactccga cggggcgtgg 2340 ctggtgtggt ggtggacgtg gtgctgctag aactgctggc cgatagtgtg ggtaccacaa 2400 agaattccgt cgacatttcg agacgggcag cactggagac attgccaccc ggaaaattga 2460 gatccaattg tttggcagat cgctgggtct gaggagctgc cggagtagtg gtactagtgg 2520 tgctacttgt agtacttgta gtcgtgctgg tagtagtggt ggtgctggtg gcattacggc 2580 tactcggctt aagcacctgg taggcgttgc gatccgattc ctggctggtc accaggcgca 2640 cccgccgcca aatgttgttg ccattaacgc tgaggctgcg cgacgccggc gtggtggcga 2700 tcaactgcat gatcagcagc aggatcagca gcaggtggcg tctaccggcc attggatgtg 2760 gtgaccttcg atgccctgga cctctgacaa tataatcaaa cgcggcacat ctcttgcaaa 2820 cgcacactaa ccacgcactc gcgatcgcga ttgttcaggt tcgtaaattc ttcagtcctc 2880 gcaggcccta gatcatgaat tcttcttctc gattctcgcg ctaaaacgtc cgctcgctcc 2940 gatcgaccaa ctgcaactga ctggcggctc tgcaagttgg gctttggacc ggcttagtcg 3000 tttgagacca gtttgacggc agccaagtcg aactaacact tgtttgagtt cgatgtgcgt 3060 ttgctaaccc ggctaacact tacaggaacg caacatgatg cgtgggaggc agttggggtt 3120 tggggcgctt tatatgattt tttgcaatgt agagtattgc acgagcattt actaaagcat 3180 cctttgaatt tgatacaaca ttcgttactc gatcttctgg ctttaaggtt tagtatatag 3240 cttcaacaac taatgttcta aatagctcaa tgtcttgctg aagggctatt gatttcctct 3300 cgaaagctat ggtacttaat ttcctattta gagccagtaa gaactcaatt tatctttagc 3360 ttccgtgcta atccgctgga acatatactt taacacaaca tttacatacg taagtttttt 3420 ttccatttga taattattcc aattagattt catattgcgg gatattaaca ttggacacaa 3480 ttttttcctc tgcggttggt tgcaacatca actgcagacg cgatccacag acctagctca 3540 ggatccacac tcaaaccgac tgcgggatgg agaacacttt cattcgttct gcatatgcgg 3600 aatttcggtt tatgggctct gatgctcgag ttggctggta ggaaagtgct atgggccatt 3660 atctattagc caaccgcttt tacggtctcc tcgcggagcc tctctcctcg aaaacgagcc 3720 aacaaaaggc caaatagcga aatccgagca caaaaggtga ttgtaaatca aaagagcgct 3780 aatggtatat cgatatacaa agtgttgagg cgggaaaggc atcgccaata gcgttagaaa 3840

108 cggcaatagc aatagcaacc cgctctgatt ccttaggtct tattgtattc ggcgcgcgct 3900 ttcagtcaac cgcagttaga attcagatca cctgaatgag tgggca 3946

<210> 77 <211> 1946 <212> DNA <213> Drosophila

<400> 77 tcgatcggag cgagcggacg ttttagcgcg agaatcgaga agaagaattc atgatctagg 60 gcctgcgagg actgaagaat ttacgaacct gaacaatcgc gatcgcgagt gcgtggttag 120 tgtgcgtttg caagagatgt gccgcgtttg attatattgt cagaggtcca gggcatcgaa 180 ggtcaccaca tccaatggcc ggtagacgcc acctgctgct gatcctgctg ctgatcatgc 240 agttgatcgc caccacgccg gcgtcgcgca gcctcagcgt taatggcaac aacatttggc 300 ggcgggtgcg cctggtgacc agccaggaat cggatcgcaa cgcctaccag gtgcttaagc 360 cgagtagccg taatgccacc agcaccacca ctactaccag cacgactaca agtactacaa 420 gtagcaccac tagtaccact actccggcag ctcctcagac ccagcgatct gccaaacaat 480 tggatctcaa ttttccgggt ggcaatgtct ccagtgctgc ccgtctcgaa atgtcgacgg 540 aattctttgt ggtacccaca ctatcggcca gcagttctag cagcaccacg tccaccacca 600 caccagccac gccccgtcgg agttcagggg cgaaggcgcg agcagccggc accactggac 660 gggtgactcc cgggagcagc tccaacagca caccgcccag tatagtgtcc acccacttgc 720 ccttcgcggg actacgcaag gagccgtggg tggtgccggt gctagtcctg gccaccctca 780 ccatgctcat gatggcagcg ttcgagatct ttgtgctctt caaggcctgg cggacgtccc 840 cgtcgcgtag gcacctcttt ctgggccaga tgctgcttct cggtctgttc gcctgcgcta 900 gtttgggggc catcatcacc gcacagccct cgttgatcag ttgcggggcc atccgcttcg 960 gagtgggcgt ggcctacgcc ctggtctttg ccgccctgct ggtcaaatgc gtatttctga 1020 ttagtctaaa tggaggggtg tatctgccgg ctccatacca gggattgctg ctcctctttg 1080 cgctgctcat ccaggtagcg atcggagggc agtggctgct cacccaacca ccggaggtat 1140 acaccaccag tgtgcctgtg atgggcagtg gcttccttag caccacggtg gcctcacaga 1200 ccaactactc ggcactgttt taccccacgt cctacacaac gctggacggg actccggaga 1260 tctacacccg gatagcggcg gttagcaccg tactaatacc gctctgcaag acgcagttct 1320 cggagctgct cttctcgctg atctacattg tctttctgat cgtcttcatc gccgtgctag 1380 ccatcaagtc gcgcggcatc agggacaact accgtgaggc cacctacatt gggctggcca 1440 tcggaggagc catccccatc tggctgggat ggatgctatg cggcctggcc gtggccgagc 1500 ggcacaagga cgcttgcgtg gccttcggtc tggtagccac atccgccacg gtcttcttgg 1560 tgatgttcat gcccaagggc aggcaactgg cggccatggg caaggagggc ctgtacgtgg 1620 aggaccgcga ggagcagttc agttccctga gtcgcgccgg ttccggctac tcgccctcgt 1680 tcttccactt caagcccatc aagtacggcg tgatgagcgg ctgcggactg cccaactctg 1740 catccaacac gggccaggga ctcagctcca aacactgctc cagtgccaac aatggaggtg 1800 gtaagtcccg ctcatacgag cttttcccct ccaaatttgt cacattttct gcccgaggcg 1860 gtcggaccca actcaagcta gatacagttc catttcggcc ccattcctct gcccttgtca 1920 gctgtcagcc tctgttaatt ttgtaa 1946

<210> 78 <211> 583 <212> PRT <213> Drosophila

<400> 78

Met Ala Gly Arg Arg His Leu Leu Leu He Leu Leu Leu He Met Gin

1 5 10 15

Leu He Ala Thr Thr Pro Ala Ser Arg Ser Leu Ser Val Asn Gly Asn

20 25 30

Asn He Trp Arg Arg Val Arg Leu Val Thr Ser Gin Glu Ser Asp Arg

35 40 45

Asn Ala Tyr Gin Val Leu Lys Pro Ser Ser Arg Asn Ala Thr Ser Thr

50 55 60

Thr Thr Thr Thr Ser Thr Thr Thr Ser Thr Thr Ser Ser Thr Thr Ser 65 70 75 80

Thr Thr Thr Pro Ala Ala Pro Gin Thr Gin Arg Ser Ala Lys Gin Leu

109 85 90 95

Asp Leu Asn Phe Pro Gly Gly Asn Val Ser Ser Ala Ala Arg Leu Glu

100 105 110

Met Ser Thr Glu Phe Phe Val Val Pro Thr Leu Ser Ala Ser Ser Ser

115 120 125

Ser Ser Thr Thr Ser Thr Thr Thr Pro Ala Thr Pro Arg Arg Ser Ser

130 135 140

Gly Ala Lys Ala Arg Ala Ala Gly Thr Thr Gly Arg Val Thr Pro Gly 145 150 155 160

Ser Ser Ser Asn Ser Thr Pro Pro Ser He Val Ser Thr His Leu Pro

165 170 175

Phe Ala Gly Leu Arg Lys Glu Pro Trp Val Val Pro Val Leu Val Leu

180 185 190

Ala Thr Leu Thr Met Leu Met Met Ala Ala Phe Glu He Phe Val Leu

195 200 205

Phe Lys Ala Trp Arg Thr Ser Pro Ser Arg Arg His Leu Phe Leu Gly

210 215 220

Gin Met Leu Leu Leu Gly Leu Phe Ala Cys Ala Ser Leu Gly Ala He 225 230 235 240

He Thr Ala Gin Pro Ser Leu He Ser Cys Gly Ala He Arg Phe Gly

245 250 255

Val Gly Val Ala Tyr Ala Leu Val Phe Ala Ala Leu Leu Val Lys Cys

260 265 270

Val Phe Leu He Ser Leu Asn Gly Gly Val Tyr Leu Pro Ala Pro Tyr

275 280 285

Gin Gly Leu Leu Leu Leu Phe Ala Leu Leu He Gin Val Ala He Gly

290 295 300

Gly Gin Trp Leu Leu Thr Gin Pro Pro Glu Val Tyr Thr Thr Ser Val 305 310 315 320

Pro Val Met Gly Ser Gly Phe Leu Ser Thr Thr Val Ala Ser Gin Thr

325 330 335

Asn Tyr Ser Ala Leu Phe Tyr Pro Thr Ser Tyr Thr Thr Leu Asp Gly

340 345 350

Thr Pro Glu He Tyr Thr Arg He Ala Ala Val Ser Thr Val Leu He

355 360 365

Pro Leu Cys Lys Thr Gin Phe Ser Glu Leu Leu Phe Ser Leu He Tyr

370 375 380

He Val Phe Leu He Val Phe He Ala Val Leu Ala He Lys Ser Arg 385 390 395 400

Gly He Arg Asp Asn Tyr Arg Glu Ala Thr Tyr He Gly Leu Ala He

405 410 415

Gly Gly Ala He Pro He Trp Leu Gly Trp Met Leu Cys Gly Leu Ala

420 425 430

Val Ala Glu Arg His Lys Asp Ala Cys Val Ala Phe Gly Leu Val Ala

435 440 445

Thr Ser Ala Thr Val Phe Leu Val Met Phe Met Pro Lys Gly Arg Gin

450 455 460

Leu Ala Ala Met Gly Lys Glu Gly Leu Tyr Val Glu Asp Arg Glu Glu 465 470 475 480

Gin Phe Ser Ser Leu Ser Arg Ala Gly Ser Gly Tyr Ser Pro Ser Phe

485 490 495

Phe His Phe Lys Pro He Lys Tyr Gly Val Met Ser Gly Cys Gly Leu

500 505 510

Pro Asn Ser Ala Ser Asn Thr Gly Gin Gly Leu Ser Ser Lys His Cys

515 520 525

Ser Ser Ala Asn Asn Gly Gly Gly Lys Ser Arg Ser Tyr Glu Leu Phe

530 535 540

Pro Ser Lys Phe Val Thr Phe Ser Ala Arg Gly Gly Arg Thr Gin Leu 545 550 555 560

Lys Leu Asp Thr Val Pro Phe Arg Pro His Ser Ser Ala Leu Val Ser

110 565 570 575

Cys Gin Pro Leu Leu He Leu 580

<210> 79 <211> 3524 <212> DNA <213> Drosophila

<400> 79 aaatttgtat aactttcagt tcttatactc agttattcca ttaatctcta atcccacgac 60 atttaaatac acatacaaat tttttataca aagtttgctt tattgactat ttttgaagca 120 catttaccat atctgtatta ttaaaatact tagcatagat tacagaattt tcagcttatt 180 ccatgaaata ctgtttgtca aacaaacaga tttcatcagt ttttgttttt ataatccttt 240 ttttttggga aagattctca tatatttaca attataattt aaaatagtct ctactttagc 300 ttactacata ttcaattaaa tctcaggagg ctgacttttc cgcggacttt tatggtggct 360 ctgacccaac tggatgcatc ctgcgccttt cctcgcagaa aagtatttta tttcacattt 420 tacgggcgtc ttggctggct gtcttacctc tggctaagat gcttatttta tacaaatccg 480 acttttgcga ttttaattgc ataaatcagc ttagttattt aattggttta ttaatctacg 540 ggagaagcaa ccattttatt ttaggtaagc actaagaaaa agattggatc ttaagattcc 600 gatattatta tatatcttta tttacttagt aaaaggatgg ggatttacgt atattttatt 660 taagagggta tattggcagt aaaatattta ttcaaattgt gggttgtaca gtttatatta 720 attattaata tgttattagc tgtcaaggca ataagaaaat gtaatccatt tcagccccct 780 tcagttaaat atattgctaa catatcgatg tgcggttgta cagactcatt ttcaaatctt 840 tgaattttaa ttctgatctc ggtttttatt acgtagacac atattaatac tgcttagtct 900 taagttcttc attcatattt ggataagaaa ggattataaa atcatttaaa tgcatactat 960 aatattggct tatttaaagg aaattcctac ttaaactggg ttacaaatct gtctgctgca 1020 ctgcgcccga tcctcttctc gcggtggtgc aaaatgcctc ctgctgctcg ctcaaacata 1080 taatcaaatt ctccggcgga gctgtcactt tgccattgga attgcatgat ttctgtgtcc 1140 ccgtggttcc ggtcttttcc gctgtcgtgg tcgaggatgt ggtggtcgat gaattgttgt 1200 tacccgcatt cagtggcagc agtggaggaa tctgcggatt gctggtcaac aggcgcttgg 1260 agccacccct ctttttactg ccctgtttgg tgaaaacact gggctccagc tggagttgag 1320 cgttgatatc ctgcttattc atacaggtaa aggccttgaa gaagctcttc cggaagttct 1380 cacttaggaa ggcataaagt atgggattca ccgccgaatt cgagtaaacc agtgccccca 1440 gaagtaggaa aatgagtatt tccagtcggg agaggtccct ttgcgcggga ttcgagtgaa 1500 tcagggccac cttggagatc cagtggtgtg taaataaaaa atcgaatata ctttataatt 1560 aattacctga gaaatccagt gagggagcca acatagaatg tatacactta tcacctgcgg 1620 attgaaaaga aggtgggaat ctacaaatga attgaactga ttatttcggc attattaccg 1680 tcagtaccag tcgagtgacc ttcctgtgag cccgcctctt ctccttggac ttcgttcctg 1740 gtttgggacc caccgatcgc agtttcctta taaccaagta gtagaaactc aggataaagc 1800 acagcggtgt ggcgaatcct aggaaaaatg tgtacagtat gaaggtggtg cccgaatgct 1860 tcttgtacgc atctggccac attatgttgc acgagtaatt gatgccatcc tcctgctcca 1920 cagtgctggc ataaaggatc acgggcagca tgaggaccgc tgaagttgac caggcaatcg 1980 ctgagaccac tttggcaata tgcagagttc gatatcgtgg cgaggaaatc gggtggcata 2040 ccgctatata tcgatccgcg gacatgatga gcagaaaaat cgacgaggtg aaggaggtga 2100 tggatgtgct caccatgtag gctttgcaca taaactcccc gaatcgccag ctgcaaattc 2160 gcattgtgta cagcagaaag ggtattccaa tcaggaagca ctcgtctgcc accgccagat 2220 tcaggatata tatattcgtg accgtttgca ttttggaaaa gcgcaacacc acgtagatca 2280 ccagggtgtt gccaaataat ccgataatgc acacaaatcc gtagagcacc acagtgaaca 2340 agtcagcaaa ggaattccgc gtggctatgc aatgttgata ggtgggcaaa tcagtgccat 2400 aaagggactc ctctggctga attgtggaac taccactaat ccatctatgg ttcagttccg 2460 tggtatataa gctctcgttc gtgttatacc aatttgtggc atttgcctct gaatcggctg 2520 tcatttcccc tttcacaaac tggaggacat ccatcatcag ccacgtaaac atatttccac 2580 ctaagcgctg tccagttcaa atttaattat tttaaatagg ttttacgcgt tgttgctccc 2640 cgctcgtttt gttcttgcat tttggcgttg ctgcaaaata cattttgtta ttacgtgaaa 2700 tattttcaga cacagttgtt ttggccaaac ttgattagtt actaattgaa atactgtggt 2760 gctattaaag aaaaaaacct aaaaccttca ctagtctagt caatattttt tattccaacg 2820 taagtttaaa atgtactgta acaattggtg ataagtattc aaatggaatt aagttaagtc 2880 tacaagtttt ataagatatt ttaatataac tagattgcag ctctttaatg catagtgtat 2940

111 atttttaata tattatgagt ttacttttaa gtggcagtca attttatttg ctgtcttaac 3000 atctttgaat cgtatgtacc ccattcgtaa tgccacttca catacagatt cttttgcaac 3060 tttactacaa cttttactga ctttctgaga aatcccctcg aaaattgaaa actttcctga 3120 acaacttgta gaaaaacaaa cctttaaaaa tacgacgtat gaaataaatc gtctgtttcc 3180 tgcttttgaa aagtgagtta ccacaaattt ggtttgtaag gcgaaggaaa ttaacattta 3240 tatttaaatt aaattgctca cagcttgaca cgtccaacaa acaagaaaca agaacttttt 3300 tatattctga cctaactcga cactttctgt aaataaatta ggcgtaagga aaagctgggc 3360 agcatttatg caaatatcag gtgaaaatat ttgtcttctc ggaagtcgga aaactccagc 3420 tatacagatc cccatggttt tgtattagga gattgaaatt taagccgatt tgtttgtgca 3480 ttccatgcac atcaaatatt gttgactgag ccaaaacaca tgtg 3524

<210> 80

<211> 1356

<212> DNA

<213> Drosophila

<400> 80 atgacagccg attcagaggc aaatgccaca aattggtata acacgaacga gagcttatat 60 accacggaac tgaaccatag atggattagt ggtagttcca caattcagcc agaggagtcc 120 ctttatggca ctgatttgcc cacctatcaa cattgcatag ccacgcggaa ttcctttgct 180 gacttgttca ctgtggtgct ctacggattt gtgtgcatta tcggattatt tggcaacacc 240 ctggtgatct acgtggtgtt gcgcttttcc aaaatgcaaa cggtcacgaa tatatatatc 300 ctgaatctgg cggtggcaga cgagtgcttc ctgattggaa taccctttct gctgtacaca 360 atgcgaattt gcagctggcg attcggggag tttatgtgca aagcctacat ggtgagcaca 420 tccatcacct ccttcacctc gtcgattttt ctgctcatca tgtccgcgga tcgatatata 480 gcggtatgcc acccgatttc ctcgccacga tatcgaactc tgcatattgc caaagtggtc 540 tcagcgattg cctggtcaac ttcagcggtc ctcatgctgc ccgtgatcct ttatgccagc 600 actgtggagc aggaggatgg catcaattac tcgtgcaaca taatgtggcc agatgcgtac 660 aagaagcatt cgggcaccac cttcatactg tacacatttt tcctaggatt cgccacaccg 720 ctgtgcttta tcctgagttt ctactacttg gttataagga aactgcgatc ggtgggtccc 780 aaaccaggaa cgaagtccaa ggagaagagg cgggctcaca ggaaggtcac tcgactggta 840 ctgacggtgg ccctgattca ctcgaatccc gcgcaaaggg acctctcccg actggaaata 900 ctcattttcc tacttctggg ggcactggtt tactcgaatt cggcggtgaa tcccatactt 960 tatgccttcc taagtgagaa cttccggaag agcttcttca aggcctttac ctgtatgaat 1020 aagcaggata tcaacgctca actccagctg gagcccagtg ttttcaccaa acagggcagt 1080 aaaaagaggg gtggctccaa gcgcctgttg accagcaatc cgcagattcc tccactgctg 1140 ccactgaatg cgggtaacaa caattcatcg accaccacat cctcgaccac gacagcggaa 1200 aagaccggaa ccacggggac acagaaatca tgcaattcca atggcaaagt gacagctccg 1260 ccggagaatt tgattatatg tttgagcgag cagcaggagg cattttgcac caccgcgaga 1320 agaggatcgg gcgcagtgca gcagacagat ttgtaa 1356

<210> 81 <211> 451 <212> PRT <213> Drosophila

<400> 81

Met Thr Ala Asp Ser Glu Ala Asn Ala Thr Asn Trp Tyr Asn Thr Asn

1 5 10 15

Glu Ser Leu Tyr Thr Thr Glu Leu Asn His Arg Trp He Ser Gly Ser

20 25 30

Ser Thr He Gin Pro Glu Glu Ser Leu Tyr Gly Thr Asp Leu Pro Thr

35 40 45

Tyr Gin His Cys He Ala Thr Arg Asn Ser Phe Ala Asp Leu Phe Thr

50 55 60

Val Val Leu Tyr Gly Phe Val Cys He He Gly Leu Phe Gly Asn Thr 65 70 75 80

Leu Val He Tyr Val Val Leu Arg Phe Ser Lys Met Gin Thr Val Thr

85 90 95

Asn He Tyr He Leu Asn Leu Ala Val Ala Asp Glu Cys Phe Leu He

112 100 105 110

Gly He Pro Phe Leu Leu Tyr Thr Met Arg He Cys Ser Trp Arg Phe

115 120 125

Gly Glu Phe Met Cys Lys Ala Tyr Met Val Ser Thr Ser He Thr Ser

130 135 140

Phe Thr Ser Ser He Phe Leu Leu He Met Ser Ala Asp Arg Tyr He 145 150 155 160

Ala Val Cys His Pro He Ser Ser Pro Arg Tyr Arg Thr Leu His He

165 170 175

Ala Lys Val Val Ser Ala He Ala Trp Ser Thr Ser Ala Val Leu Met

180 185 190

Leu Pro Val He Leu Tyr Ala Ser Thr Val Glu Gin Glu Asp Gly He

195 200 205

Asn Tyr Ser Cys Asn He Met Trp Pro Asp Ala Tyr Lys Lys His Ser

210 215 220

Gly Thr Thr Phe He Leu Tyr Thr Phe Phe Leu Gly Phe Ala Thr Pro 225 230 235 240

Leu Cys Phe He Leu Ser Phe Tyr Tyr Leu Val He Arg Lys Leu Arg

245 250 255

Ser Val Gly Pro Lys Pro Gly Thr Lys Ser Lys Glu Lys Arg Arg Ala

260 265 270

His Arg Lys Val Thr Arg Leu Val Leu Thr Val Ala Leu He His Ser

275 280 285

Asn Pro Ala Gin Arg Asp Leu Ser Arg Leu Glu He Leu He Phe Leu

290 295 300

Leu Leu Gly Ala Leu Val Tyr Ser Asn Ser Ala Val Asn Pro He Leu 305 310 315 320

Tyr Ala Phe Leu Ser Glu Asn Phe Arg Lys Ser Phe Phe Lys Ala Phe

325 330 335

Thr Cys Met Asn Lys Gin Asp He Asn Ala Gin Leu Gin Leu Glu Pro

340 345 350

Ser Val Phe Thr Lys Gin Gly Ser Lys Lys Arg Gly Gly Ser Lys Arg

355 360 365

Leu Leu Thr Ser Asn Pro Gin He Pro Pro Leu Leu Pro Leu Asn Ala

370 375 380

Gly Asn Asn Asn Ser Ser Thr Thr Thr Ser Ser Thr Thr Thr Ala Glu 385 390 395 400

Lys Thr Gly Thr Thr Gly Thr Gin Lys Ser Cys Asn Ser Asn Gly Lys

405 410 415

Val Thr Ala Pro Pro Glu Asn Leu He He Cys Leu Ser Glu Gin Gin

420 425 430

Glu Ala Phe Cys Thr Thr Ala Arg Arg Gly Ser Gly Ala Val Gin Gin

435 440 445

Thr Asp Leu 450

<210> 82 <211> 7448 <212> DNA <213> Drosophila

<400> 82 agcatgcggc tgaacaaaaa aaaactcgag gaatggccgc aatttcggtg agccatataa 60 acaacataac atatagtttt cccatccatc tacgctgtct gcgccactgg ccaagtccaa 120 gttgtcttga cggcccggca aaaagcaaca tccaaggaaa atgttgccat tttagatgcg 180 ccgcccgctg agcggaaaag tcgcgcggaa attactaaat cgatacgtgc tgcgtatcag 240 attttccatg ggttctgcat gcaaaaatac cttgaaatcc ttgcctgcag tcgcacacat 300 acacgtattg ccatctttgt acagacaagc ttgactaagt cgaactttac tatgttattc 360 tactaaaagg ttttaaagca aatgatctat actatactat actattaact tcaatagaat 420

113 tcctattttc tctggctagc aaacaaattt ggatcataaa aagattttca tggcatttat 480 gagatacgta gattgtgtgg ctcaaccttt tatctatatt atttccataa atttaagcac 540 caatggaaat gtttatctcc aaagcttagg aaaatttgga agtatatata ataaaaacct 600 tttatgtctg caaataagag atattacgtg tatactgagt ttcgcttgag tttcggagtt 660 aagaggcttc cctatagact gtttgaaaat cctataatgc cttggcattt ctaaaaggtc 720 aactgaaagc agtggaattg ctggtgggcg aggttcgtct cctaagtggc aaaatgatcc 780 agaatcggaa gcaaaccctg acgatgaaat aaactatacg agaaactgga gaacaattac 840 acatggactg tgggtgcaat tagggaccac acctttttcg ctgccgacgc gtctaaagtt 900 aatgaatatg ttaataatat gttatgcgcg tgcaaatttg ttcagggctt gaggggtttt 960 ctgtgtttct gtttccaggc gagtccagtc caatccaact ctatcgcctg atggacatgg 1020 tgttcgtggg gaactgtggc ttctggccgg cgctgaagaa gcgtttgcag gtgaggcgcc 1080 agaaggccgc ccggaagtcg acgctgtaga aggcgtagat gaagggatta atggcgctat 1140 tgaaccaacc cagccaggtg agggccttgg ccagcatttg gctggcctgg tgttcggcca 1200 ggaacggggt gatcagatag ttgataaaga agggcagcca gcaggcgata aagccaccca 1260 ccacaatgct cagggtttga gtggtcttgt tctccttctt cagcgacgta atccgattgg 1320 acagcgattt actgttggtg ttggcactgg tgttcccgct agtcgatgtc gtggttacgc 1380 ccgcctggtg atgataatga ggatggtggt gatggcttcg cagtctctcg cggtcccgct 1440 ccccatgcga atgcctaaag ctgtgtgttc gcggtggctg cgatagggag tgggtctgca 1500 cctggcccgt ttggcccggc ggctgggact gccattgcgc atccaggaga ctactgcctg 1560 ggcccatgcc actcgtcatt gtggtaatgg tcgttgaggc ggtggaagcg cgcttcagcg 1620 aggagggtcg tgtgagttcg tagcacccat tcttggcgca gcccatggag ccacctactc 1680 cgccggaggg aagggccagc agggattgac agtgtgtgcc gccagtggca ctacttgctc 1740 ctccaccccc accacctgct cctccagcgc ccatcgccgc acaattgtcg ctgtcgctga 1800 gcatcatgtc ttggagctcc ttggctatcg tctggttgga gaacgttcgc gatgtggcct 1860 gtctctggcg ctggcccacc gagctgtgct gctcctgctc cgacagctca ttctccacgt 1920 ccgctgccgt gtagcgcttg aatttctaga cacgcaaagt gcacaaggcg gttaagtcaa 1980 tgtcgatgat aaataactaa aatagagtca atgggcggca aaaggcggca aagataaaag 2040 aaacggaaac ggaagtcacg ctaggaaaag ccgaagcttt aaacactctt gtaggcatca 2100 tcatatactt taaagggaac cacactggta agcagatggc tttaagctga tttaagacta 2160 catacccaaa tgccatgcgg ccattgttct atcaactgca cgatgtgcta atctctctaa 2220 acataaaact gaatttcaga ccggttttaa tgcgtatgga gctgcctgga cttgattcag 2280 tttaagtgaa ttttaagcct attttaaaat gcacaccagg tacacataca aatgtatata 2340 tgcagatgca attttcgaag cgagcatcgt ttagtgttag ctatttagtg atgctaactt 2400 aaagctcgac ataaatgagt cgaatatgta attaccctgg tattcaagga tgtagcaaca 2460 ttagcaacat ttcataacta acatttttga aaagtattca actctaaagc gccaaactgc 2520 tctctcgtta gaaaacggtt agttgaaaac tcattaattc agctatacgg gctgccagag 2580 ttgaagtgaa aaacttgttt tatagcggac actggaccgg aaattggcac ataccccgat 2640 gcgagggtat ggtatttaaa tctgtgtgag ctcctggcat ttgggaatta tgaggcaaac 2700 gtgccacagt ttgtgccgca cgtggagtgt cctttaagcc ggagtggttc gcaatagaga 2760 tgactttcgc tggtcgggcc agcgtttgtt gtttgcagct gccgtggttt tcctattcca 2820 tattccgtat ttgtgcacta tgttggcttt ggggttttgg atggcgggag acgtgcgaat 2880 gtttgcaggc aaacagaagg acatgcggac attgggacat ggttgcggat ggctgcgacg 2940 gagcttacct tgttgtgaac acttatgtcg gtcatattgt cgtgcctgga tgcaatgaca 3000 caggaaattc ttgcatacac ataaatcatg actgccatgg gtatgaagaa ggagcccatg 3060 gccgagaaga tgacgtagcc ctcgttctgg ttgtatcggc actcgcgcag atcccttcgt 3120 cctggctcgt acctgcggga aatggaagtg agcaggatac gcttaatggg ccaccaagtt 3180 agtcaactaa tgcaggaagt tcccaattat ttgactacgg agctgtgacc ctcggagggg 3240 tcagaggtcg caagagcagc agacaattgc cagctaatta tattcgtttg ttcagctggg 3300 tgtcgccagt cagtctgctc ggaggtctcg aaatttattc taattaattt acactcacac 3360 tcggcgacat ttgtaatgct taaaatggac caaaaagata cccaaagtgg tccttcaaaa 3420 ttatgcaatg gcatcttttg acacaatttt ctgcagtcaa caaaattgtt gatttaattt 3480 catttaagca aattaagctt taattatttt tgtaagttaa ataaattaaa catctcttgg 3540 ttacatttcg gaattctgct gcctacagga acatttagta tatttcttca aaaaatctgt 3600 tgactgtgct aacgaagtta gatataaaca aagcacttta attaattctc cttttagtta 3660 gttagacaaa agtagagaga acaaaatttg ttcttaaagc tagcagatgc ggtataccaa 3720 caaggaagtt gatgtttagg ttaaaattcg gtgcatctat ttagtgtgtg gactgttgac 3780 caacttagaa gacttcttgc tgcactcctt cttcgttatg gaaataaccc tacatactga 3840 ttatttcttc aagtgtactt accatcccag catgggggga caggtgatgg ccaacgcgag 3900 cagccagacg attaggatca tgatgagggc caatcgtttg gagcgccgtt tacgggagta 3960 cgtgagcggt ctggtcacgg ccaaatatct gtcggatgga cgtgaaggat gcaaagattt 4020 acgatatcag gggaatacta tggatgtttt ggataggcct atgctcacct gtccacactg 4080 atggcgcaca ggctgagaat ggatgccgtg cagaggagca cgtccaggga gatccaaatg 4140 tcgcagagca cccagcccag ttgccacgag cctgcaatca agattccaaa ttaaaaactt 4200 tccgccagcc ttttgcagcg cggagtgggg cagccaactt aaaattccgg tccaaagtca 4260 atttgattag caacattttc catggctttc agcaaatgcc tcacctaagg ccaattaaag 4320 cggccagctc ggcaaatttt ggcaatgttt caggtcccct tcaacccgtt agtggtttaa 4380 ttctataccg aaaaagcacc gatttctcca tttgacccca acacttcgag cttctacagt 4440 gctttctcct cgtcggtggc ttgtcaagcg attaattttt aaatcaagtg ccccttaatg 4500 gtctcccggc gccaaatgaa aagttgtttt tgtgaaaggc gctaggagcg aaggaaccaa 4560 ggagctcatt acacggatat tgcctatggg ccagcacact tgggttggtc tagttcaatg 4620 taaggttgct gaatttgctg aatctccaag gactcggatt gaagcagtta aaggcaaaat 4680 ttggagtgaa ttagaaaaac acaaggatta cttaattaat tatgggaatg cttgttcagt 4740 tgtagtgtat gtgtatgttt ttatctaaaa actggagtag gaactggcac aaagcagtcg 4800 tcatatcagc actttcagtg cctaccccaa tttcaactgg atgataaggc tccaaaaagc 4860 aaactataaa tcccgaccgt gtgggtgtat tacgtcctaa cttaatgata tatgtgcgta 4920 tactttggac aaaaatgaac tgaatgtggg gcttggtaaa ttgtttgcct cgaaaaaacc 4980 tgggggcatg agtaattatg aatgagattc aaaaggtatc tccacagaga gaaactagtg 5040 gatgaaaatc ggaaaacaag cttaatgttc cataagacag aagccaagtg agctcaaatc 5100 agaagggttt agcatatttt ccattcaact tcacgagttc agcaacaaag atcaactatt 5160 ttctgacgag aataattcat tccgattcgg attgtcagtg gtccggatga ttatgacaaa 5220 ctttcgacat gccgttgcct ttaaagtatt tccacaaagt tgggctcggg aattttcccc 5280 tttttcggct ttttttttcg tgctgaggaa attgcacgag agccgaggca aaaaaatgaa 5340 agaaattctt tcagttcaaa gaatacaaat ccataaggcg agagagatac atactcgcat 5400 atttcaccta gcagcattta cataaataca cgcccccttt gccccgcccc accatctgac 5460 acacctcctc ctcgagttcc tgttcgtgtc cgtgctgcta ttcctgttcg tgctactttg 5520 ttgggataca cttggagaaa aatatatata tatgctagtc ctcctagaaa tccctacaca 5580 ttgctctaaa cagaatctca ttgatattta caggttcgaa agttccttaa atacctcaag 5640 aaacattgct actacatttt tacttcatga gatacaaatt acaaagactt gtattggatt 5700 tgttctcagt gcattcgctt ggttctgggc gccaagcttt tgttagcaat tttttgaggg 5760 atttaccgga atggcatctt catcttgtaa tcacgcgaaa agcccggcta gaggcgcctc 5820 ctttcgcgga aggactctaa tgccttaatg gcgctgccac acactcacac acacacttac 5880 acactcacac tcatacacac atagactcac ctatgagatg gacggcgacg gcggggggca 5940 tgacgaagat gcccacgaga aggtcggcca ccgccaggct catcacaaag cagttggtaa 6000 tggtgcgaag ccggcgagtg gtcaatatgg ccagtatgac cagggtgttc ccgatgacgg 6060 tgaccacgat gaaggtggca aagactgcaa tcaggatgat gccctgccag gagagcacca 6120 gatcgtagaa gtgcgcccat tcggcggccg ccgccgactc gttgtagtaa ttaaatgtgg 6180 tcacgggcgc cgtgggtccg ggttcggtga gagccactgc atccgtaccg ttcggtccgc 6240 tgggatatcc acctcctact cctcctactc ctcctccacc tgtcccattg cccgcatcct 6300 catatacgat ggatatgttt tccggcagac cacccactcc cactcccgat cccagtccca 6360 atccccgcag ggaggaggag gaggcagcca catacatgag cgacggataa atggcgctta 6420 aattattcag ctgcaagttg acagccatgg atcggccagt tgggttcaca atcgagtgtg 6480 gctagctccg gcagcaggcc gcctaggccc atccatatcg tgccatatcc ctggagttga 6540 cggagcagga acacggccca actgtggtca ttgtgtccag ttgcacgtcg ggttaactgg 6600 aattaaagga aagttcgaca tttagcaaag tcctttgcat ggtaataaaa acgaagtcaa 6660 gaggaaacaa taaccatttg catatccctt ttatgctgaa atctatttgt gtttgtttta 6720 attttttatg tatgcacgca ttatctgatt tattccttgt gacaatttcc gaaattaaat 6780 tgatttcaca gcattccata caatctcatt taaattgcaa tcgtcgaaat tgtcaatttc 6840 attcattcgc ttgcaattaa gcattcaaca atctcaaggc aaaaagtgca cagcattgaa 6900 tatacccgtc tgtgtaaatt acgttgaaag ttgtcaacgg tgtcaaaaga ttcttaagat 6960 ggcctttgta ttgggttgcc attaccgcga tacagttaaa tactttactt tctaagtaga 7020 taaacgttaa tcctttagtt agtcatgctt tcaacgaaaa tgccgaagtg cgctactgtg 7080 agcaataaat caaattaagt ttaccttatc atctagaagc acccactggc ttgatttaat 7140 ttaaaatgta tgattccatt tgctttggat taggtaccga acttagagac ttaagaataa 7200 ataattcgtg gaggtatttt ctatcagaaa attaaaaatt tttatacaaa tattcacggt 7260 ttgatttggt gaagaaaatt caagaaaatc atcaacttcg gaattcctgg cgcattctaa 7320 taatcattat atgaaaatta caaatataat gagctttata caaagtaagc actattacta 7380 caaagtggcg aaatgtatta ccaataaatt tgccaaggga atggctacat tttgggaata 7440 ttttattt 7448

115 <210> 83 <211> 1896 <212> DNA <213> Drosophila

<400> 83 atggctgtca acttgcagct gaataattta agcgccattt atccgtcgct catgtatgtg 60 gctgcctcct cctcctccct gcggggattg ggactgggat cgggagtggg agtgggtggt 120 ctgccggaaa acatatccat cgtatatgag gatgcgggca atgggacagg tggaggagga 180 gtaggaggag taggaggtgg atatcccagc ggaccgaacg gtacggatgc agtggctctc 240 accgaacccg gacccacggc gcccgtgacc acatttaatt actacaacga gtcggcggcg 300 gccgccgaat gggcgcactt ctacgatctg gtgctctcct ggcagggcat catcctgatt 360 gcagtctttg ccaccttcat cgtggtcacc gtcatcggga acaccctggt catactggcc 420 atattgacca ctcgccggct tcgcaccatt accaactgct ttgtgatgag cctggcggtg 480 gccgaccttc tcgtgggcat cttcgtcatg ccccccgccg tcgccgtcca tctcataggc 540 tcgtggcaac tgggctgggt gctctgcgac atttggatct ccctggacgt gctcctctgc 600 acggcatcca ttctcagcct gtgcgccatc agtgtggaca gatatttggc cgtgaccaga 660 ccgctcacgt actcccgtaa acggcgctcc aaacgattgg ccctcatcat gatcctaatc 720 gtctggctgc tcgcgttggc catcacctgt ccccccatgc tgggatggta cgagccagga 780 cgaagggatc tgcgcgagtg ccgatacaac cagaacgagg gctacgtcat cttctcggcc 840 atgggctcct tcttcatacc catggcagtc atgatttatg tgtatgcaag aatttcctgt 900 gtcattgcat ccaggcacga caatatgacc gacataagtg ttcacaacaa gaaattcaag 960 cgctacacgg cagcggacgt ggagaatgag ctgtcggagc aggagcagca cagctcggtg 1020 ggccagcgcc agagacaggc cacatcgcga acgttctcca accagacgat agccaaggag 1080 ctccaagaca tgatgctcag cgacagcgac aattgtgcgg cgatgggcgc tggaggagca 1140 ggtggtgggg gtggaggagc aagtagtgcc actggcggca cacactgtca atccctgctg 1200 gcccttccct ccggcggagt aggtggctcc atgggctgcg ccaagaatgg gtgctacgaa 1260 ctcacacgac cctcctcgct gaagcgcgct tccaccgcct caacgaccat taccacaatg 1320 acgagtggca tgggcccagg cagtagtctc ctggatgcgc aatggcagtc ccagccgccg 1380 ggccaaacgg gccaggtgca gacccactcc ctatcgcagc caccgcgaac acacagcttt 1440 aggcattcgc atggggagcg ggaccgcgag agactgcgaa gccatcacca ccatcctcat 1500 tatcatcacc aggcgggcgt aaccacgaca tcgactagcg ggaacaccag tgccaacacc 1560 aacagtaaat cgctgtccaa tcggattacg tcgctgaaga aggagaacaa gaccactcaa 1620 accctgagca ttgtggtggg tggctttatc gcctgctggc tgcccttctt tatcaactat 1680 ctgatcaccc cgttcctggc cgaacaccag gccagccaaa tgctggccaa ggccctcacc 1740 tggctgggtt ggttcaatag cgccattaat cccttcatct acgccttcta cagcgtcgac 1800 ttccgggcgg ccttctggcg cctcacctgc aaacgcttct tcagcgccgg ccagaagcca 1860 cagttcccca cgaacaccat gtccatcagg cgatag 1896

<210> 84 <211> 631 <212> PRT <213> Drosophila

<400> 84

Met Ala Val Asn Leu Gin Leu Asn Asn Leu Ser Ala He Tyr Pro Ser

1 5 10 15

Leu Met Tyr Val Ala Ala Ser Ser Ser Ser Leu Arg Gly Leu Gly Leu

20 25 30

Gly Ser Gly Val Gly Val Gly Gly Leu Pro Glu Asn He Ser He Val

35 40 45

Tyr Glu Asp Ala Gly Asn Gly Thr Gly Gly Gly Gly Val Gly Gly Val

50 55 60

Gly Gly Gly Tyr Pro Ser Gly Pro Asn Gly Thr Asp Ala Val Ala Leu 65 70 75 80

Thr Glu Pro Gly Pro Thr Ala Pro Val Thr Thr Phe Asn Tyr Tyr Asn

85 90 95

Glu Ser Ala Ala Ala Ala Glu Trp Ala His Phe Tyr Asp Leu Val Leu 100 105 110

116 Ser Trp Gin Gly He He Leu He Ala Val Phe Ala Thr Phe He Val

115 120 125

Val Thr Val He Gly Asn Thr Leu Val He Leu Ala He Leu Thr Thr

130 135 140

Arg Arg Leu Arg Thr He Thr Asn Cys Phe Val Met Ser Leu Ala Val 145 150 155 160

Ala Asp Leu Leu Val Gly He Phe Val Met Pro Pro Ala Val Ala Val

165 170 175

His Leu He Gly Ser Trp Gin Leu Gly Trp Val Leu Cys Asp He Trp

180 185 190

He Ser Leu Asp Val Leu Leu Cys Thr Ala Ser He Leu Ser Leu Cys

195 200 205

Ala He Ser Val Asp Arg Tyr Leu Ala Val Thr Arg Pro Leu Thr Tyr

210 215 220

Ser Arg Lys Arg Arg Ser Lys Arg Leu Ala Leu He Met He Leu He 225 230 235 240

Val Trp Leu Leu Ala Leu Ala He Thr Cys Pro Pro Met Leu Gly Trp

245 250 255

Tyr Glu Pro Gly Arg Arg Asp Leu Arg Glu Cys Arg Tyr Asn Gin Asn

260 265 270

Glu Gly Tyr Val He Phe Ser Ala Met Gly Ser Phe Phe He Pro Met

275 280 285

Ala Val Met He Tyr Val Tyr Ala Arg He Ser Cys Val He Ala Ser

290 295 300

Arg His Asp Asn Met Thr Asp He Ser Val His Asn Lys Lys Phe Lys 305 310 315 320

Arg Tyr Thr Ala Ala Asp Val Glu Asn Glu Leu Ser Glu Gin Glu Gin

325 330 335

His Ser Ser Val Gly Gin Arg Gin Arg Gin Ala Thr Ser Arg Thr Phe

340 345 350

Ser Asn Gin Thr He Ala Lys Glu Leu Gin Asp Met Met Leu Ser Asp

355 360 365

Ser Asp Asn Cys Ala Ala Met Gly Ala Gly Gly Ala Gly Gly Gly Gly

370 375 380

Gly Gly Ala Ser Ser Ala Thr Gly Gly Thr His Cys Gin Ser Leu Leu 385 390 395 400

Ala Leu Pro Ser Gly Gly Val Gly Gly Ser Met Gly Cys Ala Lys Asn

405 410 415

Gly Cys Tyr Glu Leu Thr Arg Pro Ser Ser Leu Lys Arg Ala Ser Thr

420 425 430

Ala Ser Thr Thr He Thr Thr Met Thr Ser Gly Met Gly Pro Gly Ser

435 440 445

Ser Leu Leu Asp Ala Gin Trp Gin Ser Gin Pro Pro Gly Gin Thr Gly

450 455 460

Gin Val Gin Thr His Ser Leu Ser Gin Pro Pro Arg Thr His Ser Phe 465 470 475 480

Arg His Ser His Gly Glu Arg Asp Arg Glu Arg Leu Arg Ser His His

485 490 495

His His Pro His Tyr His His Gin Ala Gly Val Thr Thr Thr Ser Thr

500 505 510

Ser Gly Asn Thr Ser Ala Asn Thr Asn Ser Lys Ser Leu Ser Asn Arg

515 520 525

He Thr Ser Leu Lys Lys Glu Asn Lys Thr Thr Gin Thr Leu Ser He

530 535 540

Val Val Gly Gly Phe He Ala Cys Trp Leu Pro Phe Phe He Asn Tyr 545 550 555 560

Leu He Thr Pro Phe Leu Ala Glu His Gin Ala Ser Gin Met Leu Ala

565 570 575

Lys Ala Leu Thr Trp Leu Gly Trp Phe Asn Ser Ala He Asn Pro Phe 580 585 590

117 He Tyr Ala Phe Tyr Ser Val Asp Phe Arg Ala Ala Phe Trp Arg Leu

595 600 605

Thr Cys Lys Arg Phe Phe Ser Ala Gly Gin Lys Pro Gin Phe Pro Thr

610 615 620

Asn Thr Met Ser He Arg Arg 625 630

<210> 85 <211> 3836 <212> DNA <213> Drosophila

<400> 85 gtgctcgaca tttcgcttgc gtcccgtaaa gaaattgtcc accacgatga cctcgtgccc 60 ctggaccatc agatcgtcga ccaagtggga gcccacgaag ccagctcctc cggtaattag 120 tatgcgtttg cgattcttat agttcaggta tttaaccttc ggatacttgc gcggtgtgct 180 ggtctggagg ctacgaactt gttcctccaa tctggccaaa ttctcccttg tgcgctggag 240 ttcggccttt tgttctcgaa taagagagct ctgctcctcg tacgccatct gaaggctcct 300 ttgtagcgga ctttccgtgg gcggccattt ggcctgaacc tcctcgacgc cgggaacgga 360 aacggcgacc tttccgcttg ggcagaagct ggccattcgg taaaggtaga ccaggagcag 420 gaggagcagc gagatggctg caacgatctt cagacgcttt ttggtggcag tcatcgtcgg 480 ttatgggttg tgtactgcag ggttccagtg cttatcagca actgatatcg ccacattgca 540 ttctcgttcg gctttagaaa ctatataaac aatacaattg cgttatcagg aggtgccaga 600 gtggccagat ggctcaaacg gaatttctaa atggattaat aatctaacgc cagggaaaag 660 ctcccgccta attttaaaat ttacatcaaa agtatcgaca ggcgaacatt ttgattttgg 720 attataaatt ataatgaatt gataatgaat tagacatttt tgttggtgat cttccccagg 780 gacgaatatt tttcgtttta acgataaaag gtcggaaatt gccaaaaaat gagtttgaaa 840 actaaatttg tttgagggct ttcttaggct ggtcagcagg gactactttc cgaataaagt 900 gtttgcccaa acggctattg aaggctattt aaactgccaa cgatgagcat cgatcgccag 960 tcgggcaaag ttcttagtgc caagtgttgt agtgctcagc atgaggcttc cttgggtgat 1020 tttctgtaca gttctgcttt taatttttac gaacaactca aatgcagata ttcccgggtg 1080 caactactac gacacggttg atatctcata cattgaaagg caaaacgatt cgtatttata 1140 tgatgacatc gaaattcctg ctagcttaac tggatactac gagttcaggc agtttgggga 1200 cggttcgatt acgccgattg aaaagcattt aagggcctgt gtttgcagcg tgcggccctg 1260 tattcgaatc tgctgcccag ccaagaactt tttggccaac ggaaaatgcg atgatggtct 1320 caaagaggag ctcgcccggt tcaaacccta tatatacttc acatacatgg acctacaggc 1380 acgagtacca ctcaccgata tggctattat cagagatgag ttctttgatt gtgatgaaat 1440 gatttacatc agcgacttta actatttctt agaagaggtt agcattcaaa tcttcaataa 1500 atgtggactt atagtttggt tccaggatgg aaaattttgg gttaccgttg acctcttcat 1560 ggaaaaacag gactactgct tgtaccggca caactttgat tcggattttc caaagtccat 1620 gtggataata cgacaccgct gcacaagcca catatctcct ggatccttag agagtaattc 1680 aattattatt tataacaaaa gtcatcaata tcgttttcat agctatatag aaagaaacga 1740 aaataactcc ttattggtgt gcaaactgct gactgcattc tgtgtgccct ttgcaagttt 1800 tttaattaca ataagctggt tttttatttc ttatattttc tttttcagtt ctaattataa 1860 caatgatatg ctttgtccta acaatcgcag tatatctata cattaagaag ctgcgaaatg 1920 ttactggcaa gtgcattgta tgctgtatag tttcgaggtt tatccagtgc ttgatcatga 1980 tactagatca tttaaatcta ttgaatggca tttgctctcc agctggttag ttcgaattgg 2040 agatatctct ggaagcttta aatgttatat cgttgacttc ttgcaggtta cagctcgcac 2100 tttttccgga tggcttccaa cctctggctc tccgtcatca gctaccatac gtggaaagtc 2160 ttgacgtcgc tcaatcgagt cgaccctaac tatcggttcc tgcggtacaa cgccttcgtc 2220 tggagcacag ccgcaatcat gacgggaagt atttatatag ttaatcagat ttgggaaaac 2280 gatcccagta aatggaactg gttgcctctg gtcggtttta ttcggtgctc ggtcaaaggt 2340 aaactttcaa tgcgattgct tttaaatcgt taccatggtt acgtattgct tttccatatc 2400 agattggcac ccatccgtct ggatctatat aagtggaccg tcgctggccc tgagcacttt 2460 caatgtcgcc atgttcgccc tgacagccat ttacattagg aaagtgaagg ggggtataaa 2520 taagttcaca aatgaggagg agggaaggat taactgcata aactttgaca gccagacgta 2580 agatatgata aaaccttgga ccttggtaaa ctagttatcc ttgccgtatt atccacatag 2640 ttacctacag ttcctgcggc tctccatcgt gatgggcctt acttggatat tcaatgtcat 2700 tccgtattct gcacggctcc acattttctg ggaatgggtc gggataatat ccgagtattt 2760

11! tcacagcgcg tttggaattg ttttgttcgt tctgctcgtc ctgaagcgca gcacatggac 2820 tctaatgatg gattcttaag cttgtttcta tataattcta ataattgttt acaattaaag 2880 ctttaaacaa ttaaagcccc tcattttatt aatatccttt gctgaacgaa ggaattgaat 2940 tgaattttat tgaactcaat aaataaatat agttttagaa aacgatgtac tttaaactgc 3000 caagaggtca ccgcgacaag cttttcactt cgccaccctc tggtaacact gattctccag 3060 ccactttcga ttctttaaaa aacatcgata ggtatcgcca aaaaaatcag ctgctctgct 3120 tgtagttttg cgatttcatt gcaattttaa tttgctttac tgttcaaaaa gaaatacagt 3180 gcaaaatatg ccgaacgaaa acgcagagga cctctcgggt caagagctaa agcagaaggc 3240 caaggaggtg gccgacgcat cggaggcaat gctcgaaaag gttgttgccg gcttaaatat 3300 ccaggacacg gcatcgacga atgcagcagg aaacgaggat gcggagcagc ctgatggtgc 3360 caagaatgag gcttcagtgt ctgcgaatgc aagtaagttt tcaatatgcc tgtgaaaagt 3420 catttagagg ctcctcctgc ggctgaaaaa atgaggttag gttttgtcgg gaactacagt 3480 ccaacctctc taacttgaac tgctgtgcta ttcatttcaa ttcaattttc aattttcatt 3540 ttctgtgcaa ttactccaaa gattagccct aacggaaaaa taaacaactc ataaatcata 3600 aatacatatt tgattttgat gaaatatgaa tatacttaca tagatacaat tgagtttttt 3660 attacgaata aaatatgtgt aatataagat ttctaccttg ttgattccat tgattgatgc 3720 ttcattgaaa ccccaaaatt gggcaaattt gttgtcatgg gaaactagtc cactgtcgtg 3780 atgccttaag ctttttttgg ggcagattag tcattccagt ttaaactaat cgaaaa 3836

<210> 86

<211> 1536

<212> DNA

<213> Drosophila

<400> 86 atgaggcttc cttgggtgat tttctgtaca gttctgcttt taatttttac gaacaactca 60 aatgcagata ttcccgggtg caactactac gacacggttg atatctcata cattgaaagg 120 caaaacgatt cgtatttata tgatgacatc gaaattcctg ctagcttaac tggatactac 180 gagttcaggc agtttgggga cggttcgatt acgccgattg aaaagcattt aagggcctgt 240 gtttgcagcg tgcggccctg tattcgaatc tgctgcccag ccaagaactt tttggccaac 300 ggaaaatgcg atgatggtct caaagaggag ctcgcccggt tcaaacccta tatatacttc 360 acatacatgg acctacaggc acgagtacca ctcaccgata tggctattat cagagatgag 420 ttctttgatt gtgatgaaat gatttacatc agcgacttta actatttctt agaagaggtt 480 agcattcaaa tcttcaataa atgtggactt atagtttggt tccaggatgg aaaattttgg 540 gttaccgttg acctcttcat ggaaaaacag gactactgct tgtaccggca caactttgat 600 tcggattttc caaagtccat gtggataata cgacaccgct gcacaagcca catatctcct 660 ggatccttag agattctaat tataacaatg atatgctttg tcctaacaat cgcagtatat 720 ctatacatta agaagctgcg aaatgttact ggcaagtgca ttgtatgctg tatagtttcg 780 aggtttatcc agtgcttgat catgatacta gatcatttaa atctattgaa tggcatttgc 840 tctccagctg gttacagctc gcactttttc cggatggctt ccaacctctg gctctccgtc 900 atcagctacc atacgtggaa agtcttgacg tcgctcaatc gagtcgaccc taactatcgg 960 ttcctgcggt acaacgcctt cgtctggagc acagccgcaa tcatgacggg aagtatttat 1020 atagttaatc agatttggga aaacgatccc agtaaatgga actggttgcc tctggtcggt 1080 tttattcggt gctcggtcaa agattggcac ccatccgtct ggatctatat aagtggaccg 1140 tcgctggccc tgagcacttt caatgtcgcc atgttcgccc tgacagccat ttacattagg 1200 aaagtgaagg ggggtataaa taagttcaca aatgaggagg agggaaggat taactgcata 1260 aactttgaca gccagacgta agatatgata aaaccttgga ccttggtaaa ctagttatcc 1320 ttgccgtatt atccacatag ttacctacag ttcctgcggc tctccatcgt gatgggcctt 1380 acttggatat tcaatgtcat tccgtattct gcacggctcc acattttctg ggaatgggtc 1440 gggataatat ccgagtattt tcacagcgcg tttggaattg ttttgttcgt tctgctcgtc 1500 ctgaagcgca gcacatggac tctaatgatg gattct 1536

<210> 87 <211> 426 <212> PRT <213> Drosophila

<400> 87

Met Arg Leu Pro Trp Val He Phe Cys Thr Val Leu Leu Leu He Phe 1 5 10 15

1 19 Thr Asn Asn Ser Asn Ala Asp He Pro Gly Cys Asn Tyr Tyr Asp Thr

20 25 30

Val Asp He Ser Tyr He Glu Arg Gin Asn Asp Ser Tyr Leu Tyr Asp

35 40 45

Asp He Glu He Pro Ala Ser Leu Thr Gly Tyr Tyr Glu Phe Arg Gin

50 55 60

Phe Gly Asp Gly Ser He Thr Pro He Glu Lys His Leu Arg Ala Cys 65 70 75 80

Val Cys Ser Val Arg Pro Cys He Arg He Cys Cys Pro Ala Lys Asn

85 90 95

Phe Leu Ala Asn Gly Lys Cys Asp Asp Gly Leu Lys Glu Glu Leu Ala

100 105 110

Arg Phe Lys Pro Tyr He Tyr Phe Thr Tyr Met Asp Leu Gin Ala Arg

115 120 125

Val Pro Leu Thr Asp Met Ala He He Arg Asp Glu Phe Phe Asp Cys

130 135 140

Asp Glu Met He Tyr He Ser Asp Phe Asn Tyr Phe Leu Glu Glu Val 145 150 155 160

Ser He Gin He Phe Asn Lys Cys Gly Leu He Val Trp Phe Gin Asp

165 170 175

Gly Lys Phe Trp Val Thr Val Asp Leu Phe Met Glu Lys Gin Asp Tyr

180 185 190

Cys Leu Tyr Arg His Asn Phe Asp Ser Asp Phe Pro Lys Ser Met Trp

195 200 205

He He Arg His Arg Cys Thr Ser His He Ser Pro Gly Ser Leu Glu

210 215 220

He Leu He He Thr Met He Cys Phe Val Leu Thr He Ala Val Tyr 225 230 235 240

Leu Tyr He Lys Lys Leu Arg Asn Val Thr Gly Lys Cys He Val Cys

245 250 255

Cys He Val Ser Arg Phe He Gin Cys Leu He Met He Leu Asp His

260 265 270

Leu Asn Leu Leu Asn Gly He Cys Ser Pro Ala Gly Tyr Ser Ser His

275 280 285

Phe Phe Arg Met Ala Ser Asn Leu Trp Leu Ser Val He Ser Tyr His

290 295 300

Thr Trp Lys Val Leu Thr Ser Leu Asn Arg Val Asp Pro Asn Tyr Arg 305 310 315 320

Phe Leu Arg Tyr Asn Ala Phe Val Trp Ser Thr Ala Ala He Met Thr

325 330 335

Gly Ser He Tyr He Val Asn Gin He Trp Glu Asn Asp Pro Ser Lys

340 345 350

Trp Asn Trp Leu Pro Leu Val Gly Phe He Arg Cys Ser Val Lys Asp

355 360 365

Trp His Pro Ser Val Trp He Tyr He Ser Gly Pro Ser Leu Ala Leu

370 375 380

Ser Thr Phe Asn Val Ala Met Phe Ala Leu Thr Ala He Tyr He Arg 385 390 395 400

Lys Val Lys Gly Gly He Asn Lys Phe Thr Asn Glu Glu Glu Gly Arg

405 410 415

He Asn Cys He Asn Phe Asp Ser Gin Thr 420 425

<210> 88 <211> 6238 <212> DNA <213> Drosophila

<400> 88

120 tgaacctgca ccaccagcca agaccccagc caagactccg accaaggcag ctgctccagc 60 cgctgttgcc agtcccgcag ctgcggcaac gtcggcagac gcctctccat ctccggccaa 120 gaaggcaacg cctgctcgcg ctgccgccgg agccaaggcc acgccgcagc gacaacgcgc 180 ccgcggtcgc tacaatcgct actaagtaga cgtcgaagga attcgtaatt taacataaca 240 taaaccttaa tatacaagaa aaaatttaca ttcacgccca ggaggaggat gaagaaagaa 300 cagatcaaat cgatctcttc ccgcaatttg acatttgcat cccaatttgc atatacactg 360 aatgaatgga aactgagaag aagacggtca acttttagtt gaaacagttg aatatattgt 420 acgacgaagc ttcttgaaac tgacgaggga gaacacaaac aagttaattg aatcgagaat 480 cgtattacct acccgattcc cccctcacag aacgcatacc atgccagcca gcgaaccaac 540 cattcaactt atgtaatcat ataaattcta taataaacaa agaaacaaaa ctagttgtaa 600 aacaaacacg attcctgtgt gtcattgcgg gatatggaaa ttggctttca atctgttgca 660 aaatgagatt cagtagcagt gtatatatct atgagggctg tacgatttcg ttttagcgca 720 caattaatac atttaatact tgatcttttt acacaagcgt tatatttaat gctacaaatc 780 ggtacagaga ttaagtgagg tgagaataca tacatataag gaaagccttg atatagtaag 840 atacgaagtg ggatatattt attatttaca gcttacgaga ctaggcgcta ctcccaggaa 900 tgctccgagg gaggcggaaa cgcttttttg agtgagatcc cactgagtcg ggaaatggga 960 ttaagtactt gggggcgcgc ggtatgaaga tcgagtggaa tcagttgaat tccagagtat 1020 tcgcctccgt catcgtcgta cgcatgcggc tctggtcgct ctgggaacga cgaagtccgc 1080 ccggacgcca tccgctcctc cagcgcttaa tgcatcccag caaggaccag ttgatggact 1140 tggagcgact cagcacatag acatacggat ccgaggtgaa gtgcagcgcc gtaagaacat 1200 cggcgatgat gaagaacttg ttcgatgcgg gcacccgatt tggagctata gccaacggga 1260 tggcgatcta aaacggagat aattgttgat aaaggccatg taaatttatt atattatatt 1320 agatttgcat aatacggaat ggttgaagat actagacgtt tagtagttac tatctgcaaa 1380 tttagaatgg tatccaccca gtactcacca tctgtggcat ccagcagatg acgaacgaga 1440 tgctgaggaa cgccattagt ttggcgaact tgatctcgac tggcgaggag tcggtggccg 1500 ccattgtgac gctaacgctg tgcctgtact gccttgccgg ctgtacactg cgatggctgt 1560 ttccgcttcc ggtgctcagc tgcgtctggt agagggtggt gccgctgctg ctctcgggat 1620 cgatgctgat ggcactgttt ttgtccctgg aaaccaggtc gtagtgcata tgccgcttgg 1680 ccgtgcgact ccttccgatc acacagagca aggtgtgggc cacgaagagg ttgcaggcca 1740 cgattacaat gcacagcagg gtacctggaa tacatcgatg gtcaaaccaa tatttgaaat 1800 gtaaccaatt tgataggaac ttaccgaaga ccataaagag caccgcatac gtcttgttcc 1860 acacgcccgg cgcatcgcga tatcgtatac acttaagctg gtccggattg gattcatcga 1920 tgtatgcacc aaaaccaacg aatggcagga acgtgatcac cacggcgatc atcagaatgc 1980 tgttgatgct cttgcgaatg agctcgtagg taatgtgcta tggcgagaga gatttgtgaa 2040 tatttaatga atgagttggc aatgtttgtg atttcctgtg tgcacttgta tcatttctta 2100 aaattaaatt acactaagaa taaaatgcat agaaaatgtt atttattata catatattgc 2160 aatcaagttc ataccttgtg gtagataaag ggtctggcta gggccatcca tctttctgcc 2220 gccataactg ctgcaatgca tccagaactg agcccgaaaa atcgccaaac cacgagtccc 2280 acgcaatcca ctcggatgaa cgactgcagg acttcctttg agagatacat tttcagcagc 2340 gtcgtggtca gcatgcccag tagagccacc agattgttgg tcgccaggca tctgaaatag 2400 ttgagagctc cgtaaatttc ggatagctta gctttatggc atttcgaagc tcataaatcg 2460 gaaagtaaat gcttttcctt gccattagcg cccaaattgc ctacagttcg ttgggttctt 2520 taataagcta cgaatataag ttgggtataa gatcgataaa atgtaataac gaattgcttt 2580 taattaattg ccacttttat aaaccgaaac tttcaatcaa gatacctcaa agctgctcca 2640 tatggttgta caactatcga ttttggttat ctaagacgtg actcggtcct taaacgcttt 2700 gattcgaacg ccgaccaata gcaatgaata attattttgg ttcgcaaaat gctcaattat 2760 aaaaaggaaa tatctattat atggatattt aaaaatttaa ttcatttttt tgaatgttta 2820 tattataaag gatgctcctc aaatttctcc attgaatatt gtgtatattc actttatatt 2880 cgttcatata tttaacattt gtatatttat actaatataa actaaagtac agatccctgt 2940 atttttatct acttagtgaa atatgtgact gtcaatggtg acttagatta agtgtttcct 3000 tttattggta tcataaaata ttgcatttgt ggggcacgaa tgtgtttcga tttgattgtt 3060 tttggggcgc cgttgacaca ggaaactcat ttgtctccgt gtgaaatgaa actatatgaa 3120 tgtagggctt ttttccaatg gaaatatatg tatatatata taaaacacac gcttggaata 3180 gaacacaaaa atgggattga caattcccgg ggattggcct aacagtccgt gcatcgttag 3240 gcatcgcaat gactttattc atttttgttt tcattatttg tttgtgcaca ttgcaccttt 3300 atacctgatt tcagcgaaca agcgattaaa atgcatttta tggtgcattg taaaagtttc 3360 gccaaaagct aaaatgtcgg aactgttcat tacagggcta aaatgtctaa atcttcaatt 3420 cgacgatttg cagtgcgaaa tgcaaaatcg ttttgctaac ttgtaaaggc aaaatcattg 3480 tttactctag caacgggaaa atacacacag ctattccgct tttcgttcat agtcaaaaag 3540 catgaaggga taccctgatt tatcgacacc gctcaagtgc cattcaccag cttcattcaa 3600

121 tcaatcaaat tacagatcaa aggctctgca tgaaggaggc ctgatgcctg aagtggaatt 3660 cgcgttaatt tatgcttcct tgacggctca aattgctggc gacagcaatt tacgcatatt 3720 acgcatacgc actgtcgtct cagcaaaaaa aaaatgttgg gaaaggagca aatcgcaaac 3780 aagctcactg aattcgccat gggccaatgc tgataaatgt aatataaatt gtgacaaata 3840 tttggcttat gaactaaaag aatttccgtg tgtgtcatag attttatcac ttctttacag 3900 tacacaccct accgaatgat taacacgatg tttaaaatat caacaaagtc tattatgagt 3960 attcgtattg agaagcgaat attttacaag aaattattat tattatatta atattaaaag 4020 gaatttggtg aaatacacaa gttttatttc actcatattt acaaaggaat agattatcat 4080 ttttgagtat tattatatct accagttttt tgcacctaag caaagttaat ttaaatacat 4140 attcatataa atcttttccc cagtatgcac atttgccaat caagtcaacc accgatcgcc 4200 gtcttcagtt acaccataaa gcttttaatg cattcgcaat tggctgcatt cccacgtcgc 4260 cgataagatt gacagaaaac agactggaat atggaatatg gacaaaatct caatgcccaa 4320 aacacatggc caacgaacta attccgtcat ttgataagat atgcaaaaat aaaacagcaa 4380 aaaccatgcc aagcaaaaca attcaaacta tgcaaatcag acccgcatag acatattata 4440 gagcaccaaa gtggccgcag ttgagagcag gttgaataaa cttacatagc catgaactgg 4500 acacaaacag tggcaaacat taactgcatg aaatgagtag ctacacgctg agaaaatatg 4560 caaaatgtca gctcaataat attattaaca ataatactat atggttttgc atgcttaata 4620 tttatgcaaa tcaaatagaa tttggtgaac tacacaacta taaattacta ctaagatggg 4680 tacattttga aagattttag ggcaagcaaa acctactttt tgcattaata tattattatt 4740 tccactatgc atagctgcac ttaccgcagc atgagcgtgt atttgctgtt tttgttgagc 4800 ttcttgcgcg ccaaaatgaa aagggccagc gaattgccaa aaacgcccag aaccatgata 4860 ataacaccaa taatcaggcg atttcgattt gcatagagcg ctttcggagg cgccacagta 4920 gttgagttgt gcggcatcaa caggtcgagc acaggtgttg tggtttccat tttgccggta 4980 tgataattgc gttcgattgc aggtgattca ggtgaaaatc taactggccg caaacgatat 5040 ttctttttca taaatgagcc tgccgcaaag gcaaggcagc tcgcaaatgc actggtagat 5100 ggaaacccgt ttcgatagcc aaattgggac ttttttccta agacacttaa ttaatgatta 5160 gcgcacgcga cacttgatca accaacgacc gaccaattcg aaggcgattc gattcgatcc 5220 gaggagcgcg tccgcagtca gccaggcgtc gatttagaat gactgccgac cgtgccgagc 5280 agagcactcg tcggctgctg cccatagctc caagctatcc aagccatcat atacacgtgg 5340 gggtggtggt aggggccagt tcggagcgag gccagttcgg ctggcgccgc cgccggtcgg 5400 atcgcatcgg atgtagcata cagcacatag acacccccaa gcgaagcggc cacccacatc 5460 cacgcccagc gatggcgacc accccatcga aaattcacag ctcgtgccag cgcctttgcc 5520 ttttggacgt gtgcgaacgg tcggaatagc acgacgaatt ttattgtttt atactctctc 5580 cacctgcggc tcactttaat ttcactttca actggatgta atattaatta tgcagttttt 5640 aagcttccat ttgattttat acagttgact aaattagaat aaaataatat actcaaaagt 5700 ttacttcagc aatatattta ctcatgtttc tttgtcattg aaaaattaac aaaacaaaaa 5760 aacagctatt tcatagatag attaattatt attattaaga gtcttcagat tcgtcatctt 5820 tagtatatgg tgtgtcattt gaaaacctat ttttgaggaa tatatgaact gaaatctgcg 5880 tatactttaa ttactgtaat gtattaaagt attgtttctt ttatacaaaa agtctaaaaa 5940 tataagcaaa caaattattt tactgaaaat ttgtttttta tgccactttt aagaaatttt 6000 gcgaattaaa catatatttt taaagctagg agcctggtaa ttatagtagt ttagctttaa 6060 ctctttgctg aaaatatttc caactaattt atttgttttc aacagaatgc attacgaaag 6120 ataaaaatta aatttgcagt tactaagcgt tgcagttgca ccttttctta ttcttatctt 6180 cttagtatat agtactgttt tgttgggcaa aaatgtttat tgtttagttt caactgcc 6238

<210> 89 <211> 1507 <212> DNA <213> Drosophila

<400> 89 actgcggacg cgctcctcgg atcgaatcga atcgccttcg aattggtcgg tcgttggttg 60 atcaagtgtc gcgtgcgcta atcattaatt aagtgtctta ggaaaaaagt cccaatttgg 120 ctatcgaaac gggtttccat ctaccagtgc atttgcgagc tgccttgcct ttgcggcagg 180 ctcatttatg aaaaagaaat atcgtttgcg gccagttaga ttttcacctg aatcacctgc 240 aatcgaacgc aattatcata ccggcaaaat ggaaaccaca acacctgtgc tcgacctgtt 300 gatgccgcac aactcaacta ctgtggcgcc tccgaaagcg ctctatgcaa atcgaaatcg 360 cctgattatt ggtgttatta tcatggttct gggcgttttt ggcaattcgc tggccctttt 420

122 cattttggcg cgcaagaagc tcaacaaaaa cagcaaatac acgctcatgc tgcgatgcct 480 ggcgaccaac aatctggtgg ctctactggg catgctgacc acgacgctgc tgaaaatgta 540 tctctcaaag gaagtcctgc agtcgttcat ccgagtggat tgcgtgggac tcgtggtttg 600 gcgatttttc gggctcagtt ctggatgcat tgcagcagtt atggcggcag aaagatggat 660 ggccctagcc agacccttta tctaccacaa gcacattacc tacgagctca ttcgcaagag 720 catcaacagc attctgatga tcgccgtggt gatcacgttc ctgccattcg ttggttttgg 780 tgcatacatc gatgaatcca atccggacca gcttaagtgt atacgatatc gcgatgcgcc 840 gggcgtgtgg aacaagacgt atgcggtgct ctttatggtc ttcggtaccc tgctgtgcat 900 tgtaatcgtg gcctgcaacc tcttcgtggc ccacaccttg ctctgtgtga tcggaaggag 960 tcgcacggcc aagcggcata tgcactacga cctggtttcc agggacaaaa acagtgccat 1020 cagcatcgat cccgagagca gcagcggcac caccctctac cagacgcagc tgagcaccgg 1080 aagcggaaac agccatcgca gtgtacagcc ggcaaggcag tacaggcaca gcgttagcgt 1140 cacaatggcg gccaccgact cctcgccagt cgagatcaag ttcgccaaac taatggcgtt 1200 cctcagcatc tcgttcgtca tctgctggat gccacagatg atcgccatcc cgttggctat 1260 agctccaaat cgggtgcccg catcgaacaa gttcttcatc atcgccgatg ttcttacggc 1320 gctgcacttc acctcggatc cgtatgtcta tgtgctgagt cgctccaagt ccatcaactg 1380 gtccttgctg ggatgcatta agcgctggag gagcggatgg cgtccgggcg gacttcgtcg 1440 ttcccagagc gaccagagcc gcatgcgtac gacgatgacg gaggcgaata ctctggaatt 1500 caactga 1507

<210> 90 <211> 412 <212> PRT <213> Drosophila

<40( )> 90

Met Glu Thr Thr Thr Pro Val Leu Asp Leu Leu Met Pro His Asn Ser

1 5 10 15

Thr Thr Val Ala Pro Pro Lys Ala Leu Tyr Ala Asn Arg Asn Arg Leu 20 25 30

He He Gly Val He He Met Val Leu Gly Val Phe Gly Asn Ser Leu 35 40 45

Ala Leu Phe He Leu Ala Arg Lys Lys Leu Asn Lys Asn Ser Lys Tyr 50 55 60

Thr Leu Met Leu Arg Cys Leu Ala Thr Asn Asn Leu Val Ala Leu Leu

65 70 75 80

Gly Met Leu Thr Thr Thr Leu Leu Lys Met Tyr Leu Ser Lys Glu Val 85 90 95

Leu Gin Ser Phe He Arg Val Asp Cys Val Gly Leu Val Val Trp Arg 100 105 110

Phe Phe Gly Leu Ser Ser Gly Cys He Ala Ala Val Met Ala Ala Glu 115 120 125

Arg Trp Met Ala Leu Ala Arg Pro Phe He Tyr His Lys His He Thr 130 135 140

Tyr Glu Leu He Arg Lys Ser He Asn Ser He Leu Met He Ala Val

145 150 155 160

Val He Thr Phe Leu Pro Phe Val Gly Phe Gly Ala Tyr He Asp Glu 165 170 175

Ser Asn Pro Asp Gin Leu Lys Cys He Arg Tyr Arg Asp Ala Pro Gly 180 185 190

Val Trp Asn Lys Thr Tyr Ala Val Leu Phe Met Val Phe Gly Thr Leu 195 200 205

Leu Cys He Val He Val Ala Cys Asn Leu Phe Val Ala His Thr Leu 210 215 220

Leu Cys Val He Gly Arg Ser Arg Thr Ala Lys Arg His Met His Tyr

225 230 235 240

Asp Leu Val Ser Arg Asp Lys Asn Ser Ala He Ser He Asp Pro Glu 245 250 255

Ser Ser Ser Gly Thr Thr Leu Tyr Gin Thr Gin Leu Ser Thr Gly Ser 260 265 270

123 Gly Asn Ser His Arg Ser Val Gin Pro Ala Arg Gin Tyr Arg His Ser 275 280 285

Val Ser Val Thr Met Ala Ala Thr Asp Ser Ser Pro Val Glu He Lys 290 295 300

Phe Ala Lys Leu Met Ala Phe Leu Ser He Ser Phe Val He Cys Trp

305 310 315 320

Met Pro Gin Met He Ala He Pro Leu Ala He Ala Pro Asn Arg Val 325 330 335

Pro Ala Ser Asn Lys Phe Phe He He Ala Asp Val Leu Thr Ala Leu 340 345 350

His Phe Thr Ser Asp Pro Tyr Val Tyr Val Leu Ser Arg Ser Lys Ser 355 360 365

He Asn Trp Ser Leu Leu Gly Cys He Lys Arg Trp Arg Ser Gly Trp 370 375 380

Arg Pro Gly Gly Leu Arg Arg Ser Gin Ser Asp Gin Ser Arg Met Arg 385 390 395 400

Thr Thr Met Thr Glu Ala Asn Thr Leu Glu Phe Asn 405 410

<210> 91 <211> 5340 <212> DNA <213> Drosophila

<400> 91 tacactcatg aatattcaaa caaaactctt caacttgtct ggcatatatc catagacaat 60 tacgcgggta tgtatgctgg gttttgtgtt cttaaaatcg tatatctgct gcaggattga 120 catcgaactg cttaacccca cgacggcaac cattcgtcga aaaagtttga acacagttta 180 tatttttgca atattctaag tactataacc taccaaaata actgtaaaag aaagtttcta 240 tgaacgtttg aaatcaaaat taggtccgat tttgcgtagt tttcgacaaa gtgtcaccgt 300 caaaagggct tcgactggca tatccctcaa agggttaaca tgcttttctt tggtcttctt 360 atggcctacc cccttcatat gtctgctttt cattgatata ttctgcggaa caacaaaaga 420 agtattattc tatattggga tatgctttag agttttggtt tgtagggttt tctagtctcg 480 gtaaatgtgt atatcttatg cttaatttat tttattagct atcatatcat atactttgca 540 tggttatcat agattggtta ttaacattaa aatatttatt gtctaaaaca tttcgccccg 600 cttagtgcca ctctagacct atgtatgcat cccaaatcgg attgcttgtt ttccccccca 660 acgattctaa ctatagcaca cacctttggc tacttacaga taactcttcc ctgtccaccg 720 attaaatttt gaatttaata agtgtttgat tctaatactt tgctgatggt cgaaatccag 780 cagatattcc attaagcgga gcactttcgt tgggtatgta tagaaaactt atgggcctaa 840 ggaggtgtaa ggggtttggg aatggaaaag tttgcaaggc gccagactct cggggctctg 900 aagtgtctgg tcctttgcgc aagtgcagtg caaaatggaa atctatcagg gatttaactc 960 aaccaccagc agcttaacca cttcagatcc ccaaaccatc ttaggtcatg tgcagatccc 1020 ccttgaggat ccgcgtaaag gtcttcttga actgctgatt ggccagagcg tagcaaaaag 1080 gattcatcgg gctgttggcg tagcagagga agtacgagaa catgtagagg tgttcattga 1140 tgcagggcgg atgccggcag aatccctcga cgagggccaa cacatggtag ggtgtccagc 1200 aggccacgaa gcagcccaaa atgaacgaga tcgtgcgaaa cgctttgcga gcacgattct 1260 ccgacttgga cttctgccgt ccacccactc caaggatcag gggtagagcc ttcttgctct 1320 tgaagtgctt tcctatcgaa tgaatgaatg cccttttgct ggagtttcgg ctggccgcca 1380 aactcttctc ctccctgttg gcatcgtcat cccccgcgtt ctttttggtg gcaccaacac 1440 cgtcttgttc cccgcctcca cccacaccgc ccgtactgct ggtggtgccc gaggtggagg 1500 gcatcttgtt ggtattactg tccgaggttt ctcgctcctc aatcctttcc agtggcaccg 1560 gtggtgttac acccgccgcc gactggggcg ttcccgtttg tggcgttgaa gtctttacct 1620 tgggtgagag tggcattggt ggcatcgggg aatagagtat ggcatccttg ctgctggtct 1680 ccataggact ggaggcccgg cgatggggac agtccgcagc tagctttccg ggcacatcca 1740 acaggcagat ggcctcaatg cagctctccc gcctcacctt agcaaagtcc tcgattcctg 1800 tgtacgagac gagaagacgt ttttcaatgg ccaccgcctc ctcgatactc tgactctgac 1860 tctggttgtg attcggattc aggttgaggc tcaggctttg gctgggactc tggttttggc 1920 tgggagtttg actgaggctc tggttcaggt tcgattttgg tggatttcgg cgtgcgggcg 1980 gtggtggagg caggactggt ggtttcccct ggacgctgtc attcggggag gtcgtcgagt 2040

124 tggccgtcac actggccagc atggcggagc tctcgtccat atagcgtagc tccgagttcg 2100 tcatcaggtc ataggtcagg gccagttcac tgttaccgga actattccca aagggacgat 2160 ccgagtagtc atcggagagc ggggtggggc actgaaaggc gtcgggaggt ggcaaaatgg 2220 tctgcaccag accctgatgc acttgatcgc tagggacctc gatgggtgcc aagtccacgg 2280 gggacagggg atcactggtg ttgagtaatg ttggaggagc ggacaggtcg accaaacgat 2340 catgctcggc tatctgggac agtgtggagc aggatgtgcg cttgggcctg tccagcggtg 2400 ggttcggctg gttttggtgg tgctggtggt gcggttgttg ctggttctgg tggtggtgca 2460 gggagcgcat ctcttccttg ctctgcgccc gctgtaacgg actctggttg tgatggtgct 2520 gttggtggtg gtggtactgg tgcatggcct cgatcgactt ggagttagtg gtgctcttct 2580 gcaagttacc tttgccacga gtggccagca gggcggcctg tgccccaaag accagaccaa 2640 tcgatgaccg cttcctcatg ttgttcaatt tctgctgggt gatcaactgc tgggcctggt 2700 tgacggatga ttcctcatcg gaatcgaagg caggactgct ggatctctcg ctcttttccg 2760 catccacggc tgcctcacgt tttttcgcct cctcctggat ttttgctgcc gacgctctcc 2820 tctgttccgg tgtcatcttc tccacttcct cggtggccac ggccagagga tttgcctgac 2880 cggaaccact taatctctta atcactgtgg tgcaggcact atccaaatcg gtttgatctc 2940 ccgcaagttc cactttggtc tttaggattt tctcctcaat cacaccaatg ccagctgcat 3000 gacctgccat tccggacatc gctccagcac tcagtgccac catggattgc attttccgtt 3060 gcttcgcctc actgcgcttt tgcatatcat aggctgtttt gtagatcccg gcatataaga 3120 caaaaagcac aattagtgtg gtccaatagt agccaatgat tagggccgta ttaaagatcg 3180 gatccttgag aaactgaacg gcgcactggc caggaagtag atcccgcttg ccggtgaagt 3240 gctcccatcc aaaaatcgag atgaagaaga gcagagcggg aatgatccaa gtgattgtga 3300 ccatatatat cactctggtt ctcgtcctcc aactccggta cttggcggca atcttcacag 3360 agcagtagcg atctatcgtg atcaacagca ccgtgtactg ggacaccaga cacacagtat 3420 agtcgacgga aagccagaga tcgcagagca tcggacccag gtcccaataa cccttgagca 3480 cgtatatcgt gtagaagggc atcgaaacgg ttcctgaaat atgggtttat agtacaatta 3540 ataatttttt ttttttgaat ttaaggtaaa atagttacta cctattagca tatccgtggc 3600 tgctagggag gcaataaagt agttgctggg ctgccgaata ttcctgtcca cgatgaaggc 3660 cagtagcacc aggatattac cgcccaccgt aagaatgata cagatcgcca ggcatatggc 3720 tatcaggatc gtctgccaca gtgcaaatgg tggcaaaaca ggaccaagaa tctccgagtc 3780 ggaactggat cccgacatgg tggaaccgcc atcagaggat tgatttctaa cagccaacag 3840 aaggttcgta ttgttcacat cgaagttcct gtaccattgc agctgttcat taaccggcca 3900 ggaattgaag tcactgctct cgccatagat cttggccgcc tccaacagac gtttgcactc 3960 cgtgtgcgtc aggactcgct tgaaaatgaa gctgcacagc ttatcccgct cccttctaag 4020 gctcctggaa gtgcgaaagt aaatatatgc ttaattagag ttgacataaa actatctcta 4080 tctctatctc tatctctatc tctatctcta tctctaaact aatgtccttg aaaacaaatt 4140 ctaacaatgt atctttttaa gatctccatt ttctaaaagc tttgccactg aaattactat 4200 tctaataggc gcctttattc tattaagaca actcaccagt cggtgatcca cttgttcttg 4260 atggtataga tggagtcgct ggagttgcca ttcaggccag tcagctcctc ctcgcccgcc 4320 gacttgttaa gcgaccgcat ccttaaccgc tccgccctct tcccgctctg gccacgtccc 4380 gctccctgct ccccgcactt cgcctctgcg ctccacaacc tctgcggttt ttatggtaat 4440 ttcaagttgt tcctccttaa tgtgctgtcg acggcggttg tctcggaatg cttacattgc 4500 ctccatggaa tgccaagact tgtctccggt caggtgcagc atctgcaaga ggcaacaaaa 4560 gcagccacag tcttggttag cacttgaaaa aatatagagg ttattaatat tatatgatat 4620 aatatatata tgcatataaa atatgatata atatatatat gcatataaaa tatgatataa 4680 tttatatatg tatacataat atgataaaaa gtctgaattt cagaattctg ccagaagtcg 4740 ttttccatcc aaaaattaat tgttttttaa tcgaattttt ggtaataata atccgaataa 4800 ggaatggaat atttcgttga gatcgtaaat aaattttaaa tccgtgtgtg tttgatttgg 4860 aaccagtcgt tttccatcca aaaattaatt gttttttaat cgaatttttg gtaataataa 4920 tccgaataag gaatggaata tctcgttgag atcgtaaata aattttaaaa tatatgtgtg 4980 tttgatttgg aaccatttat ttttttcacg atgttgccac tttccaaaaa ttcgaaaatt 5040 gacaaaaaaa atatttttcc gttttagttg cgcgaccatt tttagccaaa taatagtaaa 5100 aaatctattt gaaaaataca ttgtcttcat tagatggtgg aaaataatga aaatatgaaa 5160 ataatggaaa ttaaattaaa tcaaaattag taatgaaaat caagtattta ctaaataaag 5220 aaactttctt ttcgtgtagt cttcgtggac gtcttcgctt ccgccaagtt taaactaatt 5280 ttgcaaccgt taactggcaa ccggcgactg gcgatgcaat ttgcttgtgg cagttgcttc 5340

<210> 92

125 <211> 3060

<212> DNA

<213> Drosophila

<400> 92 atgcggtcgc ttaacaagtc ggcgggcgag gaggagctga ctggcctgaa tggcaactcc 60 agcgactcca tctataccat caagaacaag tggatcaccg actggagcct tagaagggag 120 cgggataagc tgtgcagctt cattttcaag cgagtcctga cgcacacgga gtgcaaacgt 180 ctgttggagg cggccaagat ctatggcgag agcagtgact tcaattcctg gccggttaat 240 gaacagctgc aatggtacag gaacttcgat gtgaacaata cgaaccttct gttggctgtt 300 agaaatcaat cctctgatgg cggttccacc atgtcgggat ccagttccga ctcggagatt 360 cttggtcctg ttttgccacc atttgcactg tggcagacga tcctgatagc catatgcctg 420 gcgatctgta tcattcttac ggtgggcggt aatatcctgg tgctactggc cttcatcgtg 480 gacaggaata ttcggcagcc cagcaactac tttattgcct ccctagcagc cacggatatg 540 ctaataggaa ccgtttcgat gcccttctac acgatatacg tgctcaaggg ttattgggac 600 ctgggtccga tgctctgcga tctctggctt tccgtcgact atactgtgtg tctggtgtcc 660 cagtacacgg tgctgttgat cacgatagat cgctactgct ctgtgaagat tgccgccaag 720 taccggagtt ggaggacgag aaccagagtg atatatatgg tcacaatcac ttggatcatt 780 cccgctctgc tcttcttcat ctcgattttt ggatgggagc acttcaccgg caagcgggat 840 ctacttcctg gccagtgcgc cgttcagttt ctcaaggatc cgatctttaa tacggcccta 900 atcattggct actattggac cacactaatt gtgctttttg tcttatatgc cgggatctac 960 aaaacagcct atgatatgca aaagcgcagt gaggcgaagc aacggaaaat gcaatccatg 1020 gtggcactga gtgctggagc gatgtccgga atggcaggtc atgcagctgg cattggtgtg 1080 attgaggaga aaatcctaaa gaccaaagtg gaacttgcgg gagatcaaac cgatttggat 1140 agtgcctgca ccacagtgat taagagatta agtggttccg gtcaggcaaa tcctctggcc 1200 gtggccaccg aggaagtgga gaagatgaca ccggaacaga ggagagcgtc ggcagcaaaa 1260 atccaggagg aggcgaaaaa acgtgaggca gccgtggatg cggaaaagag cgagagatcc 1320 agcagtcctg ccttcgattc cgatgaggaa tcatccgtca accaggccca gcagttgatc 1380 acccagcaga aattgaacaa catgaggaag cggtcatcga ttggtctggt ctttggggca 1440 caggccgccc tgctggccac tcgtggcaaa ggtaacttgc agaagagcac cactaactcc 1500 aagtcgatcg aggccatgca ccagtaccac caccaccaac agcaccatca caaccagagt 1560 ccgttacagc gggcgcagag caaggaagag atgcgctccc tgcaccacca ccagaaccag 1620 caacaaccgc accaccagca ccaccaaaac cagccgaacc caccgctgga caggcccaag 1680 cgcacatcct gctccacact gtcccagata gccgagcatg atcgtttggt cgacctgtcc 1740 gctcctccaa cattactcaa caccagtgat cccctgtccc ccgtggactt ggcacccatc 1800 gaggtcccta gcgatcaagt gcatcagggt ctggtgcaga ccattttgcc acctcccgac 1860 gcctttcagt gccccacccc gctctccgat gactactcgg atcgtccctt tgggaatagt 1920 tccggtaaca gtgaactggc cctgacctat gacctgatga cgaactcgga gctacgctat 1980 atggacgaga gctccgccat gctggccagt gtgacggcca actcgacgac ctccccgaat 2040 gacagcgtcc aggggaaacc accagtcctg cctccaccac cgcccgcacg ccgaaatcca 2100 ccaaaatcga acctgaacca gagcctcagt caaactccca gccaaaacca gagtcccagc 2160 caaagcctga gcctcaacct gaatccgaat cacaaccaga gtcagagtca gagtatcgag 2220 gaggcggtgg ccattgaaaa acgtcttctc gtctcgtaca caggaatcga ggactttgct 2280 aaggtgaggc gggagagctg cattgaggcc atctgcctgt tggatgtgcc cggaaagcta 2340 gctgcggact gtccccatcg ccgggcctcc agtcctatgg agaccagcag caaggatgcc 2400 atactctatt ccccgatgcc accaatgcca ctctcaccca aggtaaagac ttcaacgcca 2460 caaacgggaa cgccccagtc ggcggcgggt gtaacaccac cggtgccact ggaaaggatt 2520 gaggagcgag aaacctcgga cagtaatacc aacaagatgc cctccacctc gggcaccacc 2580 agcagtacgg gcggtgtggg tggaggcggg gaacaagacg gtgttggtgc caccaaaaag 2640 aacgcggggg atgacgatgc caacagggag gagaagagtt tggcggccag ccgaaactcc 2700 agcaaaaggg cattcattca ttcgatagga aagcacttca agagcaagaa ggctctaccc 2760 ctgatccttg gagtgggtgg acggcagaag tccaagtcgg agaatcgtgc tcgcaaagcg 2820 tttcgcacga tctcgttcat tttgggctgc ttcgtggcct gctggacacc ctaccatgtg 2880 ttggccctcg tcgagggatt ctgccggcat ccgccctgca tcaatgaaca cctctacatg 2940 ttctcgtact tcctctgcta cgccaacagc ccgatgaatc ctttttgcta cgctctggcc 3000 aatcagcagt tcaagaagac ctttacgcgg atcctcaagg gggatctgca catgacctaa 3060

<210> 93 <211> 1019

126 <212> PRT

<213> Drosophila

<400> 93

Met Arg Ser Leu Asn Lys Ser Ala Gly Glu Glu Glu Leu Thr Gly Leu

1 5 10 15

Asn Gly Asn Ser Ser Asp Ser He Tyr Thr He Lys Asn Lys Trp He

20 25 30

Thr Asp Trp Ser Leu Arg Arg Glu Arg Asp Lys Leu Cys Ser Phe He

35 40 45

Phe Lys Arg Val Leu Thr His Thr Glu Cys Lys Arg Leu Leu Glu Ala

50 55 60

Ala Lys He Tyr Gly Glu Ser Ser Asp Phe Asn Ser Trp Pro Val Asn 65 70 75 80

Glu Gin Leu Gin Trp Tyr Arg Asn Phe Asp Val Asn Asn Thr Asn Leu

85 90 95

Leu Leu Ala Val Arg Asn Gin Ser Ser Asp Gly Gly Ser Thr Met Ser

100 105 110

Gly Ser Ser Ser Asp Ser Glu He Leu Gly Pro Val Leu Pro Pro Phe

115 120 125

Ala Leu Trp Gin Thr He Leu He Ala He Cys Leu Ala He Cys He

130 135 140

He Leu Thr Val Gly Gly Asn He Leu Val Leu Leu Ala Phe He Val 145 150 155 160

Asp Arg Asn He Arg Gin Pro Ser Asn Tyr Phe He Ala Ser Leu Ala

165 170 175

Ala Thr Asp Met Leu He Gly Thr Val Ser Met Pro Phe Tyr Thr He

180 185 190

Tyr Val Leu Lys Gly Tyr Trp Asp Leu Gly Pro Met Leu Cys Asp Leu

195 200 205

Trp Leu Ser Val Asp Tyr Thr Val Cys Leu Val Ser Gin Tyr Thr Val

210 215 220

Leu Leu He Thr He Asp Arg Tyr Cys Ser Val Lys He Ala Ala Lys 225 230 235 240

Tyr Arg Ser Trp Arg Thr Arg Thr Arg Val He Tyr Met Val Thr He

245 250 255

Thr Trp He He Pro Ala Leu Leu Phe Phe He Ser He Phe Gly Trp

260 265 270

Glu His Phe Thr Gly Lys Arg Asp Leu Leu Pro Gly Gin Cys Ala Val

275 280 285

Gin Phe Leu Lys Asp Pro He Phe Asn Thr Ala Leu He He Gly Tyr

290 295 300

Tyr Trp Thr Thr Leu He Val Leu Phe Val Leu Tyr Ala Gly He Tyr 305 310 315 320

Lys Thr Ala Tyr Asp Met Gin Lys Arg Ser Glu Ala Lys Gin Arg Lys

325 330 335

Met Gin Ser Met Val Ala Leu Ser Ala Gly Ala Met Ser Gly Met Ala

340 345 350

Gly His Ala Ala Gly He Gly Val He Glu Glu Lys He Leu Lys Thr

355 360 365

Lys Val Glu Leu Ala Gly Asp Gin Thr Asp Leu Asp Ser Ala Cys Thr

370 375 380

Thr Val He Lys Arg Leu Ser Gly Ser Gly Gin Ala Asn Pro Leu Ala 385 390 395 400

Val Ala Thr Glu Glu Val Glu Lys Met Thr Pro Glu Gin Arg Arg Ala

405 410 415

Ser Ala Ala Lys He Gin Glu Glu Ala Lys Lys Arg Glu Ala Ala Val

420 425 430

Asp Ala Glu Lys Ser Glu Arg Ser Ser Ser Pro Ala Phe Asp Ser Asp 435 440 445

127 Glu Glu Ser Ser Val Asn Gin Ala Gin Gin Leu He Thr Gin Gin Lys

450 455 460

Leu Asn Asn Met Arg Lys Arg Ser Ser He Gly Leu Val Phe Gly Ala 465 470 475 480

Gin Ala Ala Leu Leu Ala Thr Arg Gly Lys Gly Asn Leu Gin Lys Ser

485 490 495

Thr Thr Asn Ser Lys Ser He Glu Ala Met His Gin Tyr His His His

500 505 510

Gin Gin His His His Asn Gin Ser Pro Leu Gin Arg Ala Gin Ser Lys

515 520 525

Glu Glu Met Arg Ser Leu His His His Gin Asn Gin Gin Gin Pro His

530 535 540

His Gin His His Gin Asn Gin Pro Asn Pro Pro Leu Asp Arg Pro Lys 545 550 555 560

Arg Thr Ser Cys Ser Thr Leu Ser Gin He Ala Glu His Asp Arg Leu

565 570 575

Val Asp Leu Ser Ala Pro Pro Thr Leu Leu Asn Thr Ser Asp Pro Leu

580 585 590

Ser Pro Val Asp Leu Ala Pro He Glu Val Pro Ser Asp Gin Val His

595 600 605

Gin Gly Leu Val Gin Thr He Leu Pro Pro Pro Asp Ala Phe Gin Cys

610 615 620

Pro Thr Pro Leu Ser Asp Asp Tyr Ser Asp Arg Pro Phe Gly Asn Ser 625 630 635 640

Ser Gly Asn Ser Glu Leu Ala Leu Thr Tyr Asp Leu Met Thr Asn Ser

645 650 655

Glu Leu Arg Tyr Met Asp Glu Ser Ser Ala Met Leu Ala Ser Val Thr

660 665 670

Ala Asn Ser Thr Thr Ser Pro Asn Asp Ser Val Gin Gly Lys Pro Pro

675 680 685

Val Leu Pro Pro Pro Pro Pro Ala Arg Arg Asn Pro Pro Lys Ser Asn

690 695 700

Leu Asn Gin Ser Leu Ser Gin Thr Pro Ser Gin Asn Gin Ser Pro Ser 705 710 715 720

Gin Ser Leu Ser Leu Asn Leu Asn Pro Asn His Asn Gin Ser Gin Ser

725 730 735

Gin Ser He Glu Glu Ala Val Ala He Glu Lys Arg Leu Leu Val Ser

740 745 750

Tyr Thr Gly He Glu Asp Phe Ala Lys Val Arg Arg Glu Ser Cys He

755 760 765

Glu Ala He Cys Leu Leu Asp Val Pro Gly Lys Leu Ala Ala Asp Cys

770 775 780

Pro His Arg Arg Ala Ser Ser Pro Met Glu Thr Ser Ser Lys Asp Ala 785 790 795 800

He Leu Tyr Ser Pro Met Pro Pro Met Pro Leu Ser Pro Lys Val Lys

805 810 815

Thr Ser Thr Pro Gin Thr Gly Thr Pro Gin Ser Ala Ala Gly Val Thr

820 825 830

Pro Pro Val Pro Leu Glu Arg He Glu Glu Arg Glu Thr Ser Asp Ser

835 840 845

Asn Thr Asn Lys Met Pro Ser Thr Ser Gly Thr Thr Ser Ser Thr Gly

850 855 860

Gly Val Gly Gly Gly Gly Glu Gin Asp Gly Val Gly Ala Thr Lys Lys 865 870 875 880

Asn Ala Gly Asp Asp Asp Ala Asn Arg Glu Glu Lys Ser Leu Ala Ala

885 890 895

Ser Arg Asn Ser Ser Lys Arg Ala Phe He His Ser He Gly Lys His

900 905 910

Phe Lys Ser Lys Lys Ala Leu Pro Leu He Leu Gly Val Gly Gly Arg 915 920 925

128 Gin Lys Ser Lys Ser Glu Asn Arg Ala Arg Lys Ala Phe Arg Thr He

930 935 940

Ser Phe He Leu Gly Cys Phe Val Ala Cys Trp Thr Pro Tyr His Val 945 950 955 960

Leu Ala Leu Val Glu Gly Phe Cys Arg His Pro Pro Cys He Asn Glu

965 970 975

His Leu Tyr Met Phe Ser Tyr Phe Leu Cys Tyr Ala Asn Ser Pro Met

980 985 990

Asn Pro Phe Cys Tyr Ala Leu Ala Asn Gin Gin Phe Lys Lys Thr Phe

995 1000 1005

Thr Arg He Leu Lys Gly Asp Leu His Met Thr 1010 1015

<210> 94 <211> 4172 <212> DNA <213> Drosophila

<400> 94 gacatacgca ggcggagaat tgatttgatt tctgttattg ttgcttatca ctatcgattt 60 cgattattca aagtcccttt ttgccctgcg gcgaacggcg attgccctca gtttctgagt 120 tcctgcaaat caaatgcaat tatgtcgttc aatcgtctga atgctgaacg gtaaatcgag 180 taaacaagag tgggcggagg tggtctgaat aatttatgac cgcccattaa ttattactca 240 tagagctgtc ctatgactta tcgactttaa gccaattgga gaggggggag taaggctggc 300 agggcaaccc gatcaaaacg aaaaatcaaa gtgtgggtat cattgtgtat ttcgtaaatt 360 agaaggccaa tttggtggca attcctgttt gtgatacaat tcctggccgc cattgtaccc 420 gtggtacttc taggaattca ttaaatgtat ccaatttgct gtcaaggtaa tttacttggt 480 gaacaattaa gttcaagtag ctatgtttag tcatttcaaa gttatgtctt tacaatttat 540 tttatataaa tactaagtgc tattcttaat taagcatctg cacttaaggt tttctctata 600 aggagcctat tcaaatagtt ttcattaatg ttttcattct ttccctttct cgattgcagc 660 tccaacttcc ggcgctttgg tggcgtaaaa tgtttgccac caatatccgt tcggttgccg 720 tagaaatcgt cctggtggcg ccgtgagctc tcgtcctttt cctttcgcga gtcctgaatc 780 cccgtccctc gctcatttcc ggtgcgccgt ttttacattt gcaattcgaa tcggattgaa 840 atcggaatcg gaatcagaat cggcgcgagg acatttccat tccttcccat tctcttttta 900 tttttttttt ttgcgatctg cgttgcatat gcgagggcta attagcatgc ggcatttcca 960 gcaatcagag tagagcgcac aataggaata ataacgcgga atggaagagg atgtgtatgc 1020 ctcgctaggt gcctacaacg acagcggtgg cgacgattgg agcagctcgg agcacctggt 1080 cctgtgggag gaggatgaga cgcagcgaac gactgctaat gccaccagtc ggcataatca 1140 actgcatgtg gccaggtgga atgccaccgg caatgcgacc atcagcgcga ccttcgagga 1200 cgtacccttc gatgcgaaca actactgggc cctattggcc ctcgtcctcg tcctgggaac 1260 agcggccggg aacatccttg tctgcctggc catcgcctgg gagcgccggc tgcagaatgt 1320 gaccaactac ttccttatgt cgctggccat caccgatctc atggtcgccg tgctggtcat 1380 gccgctgggc atccttacgc tggtgaaagg tgagtccttt gtcccattca aagtccggaa 1440 cagaggtatt ttttgcagcc accttttgtt gagggactca atggacactt gagtaagtca 1500 cttgtgcgcc aggattggct tgtgcggcta atcttagttg gaaaagttcc ttttccataa 1560 tttcatagtt tactctaacg aaaatgagtt ggtggaaaac ttgatgaaaa ttaatattaa 1620 ttacttgggg caagggaaaa aagagtgaga agttttgata gttgttaaat ttttaaggct 1680 tttaaaaagt gacgaagaag atgcaaggaa acgcaaagat gtagggaata tacaaaatta 1740 ttttaaatct taagatttct tatatttgca atttaaatgc ggtaaatgcg aatcaattga 1800 ataatgtaca gggaattgtg aaaaaatatg gatatttacg gattcctttt gctgcaactc 1860 aatccgaatg ataatctctc caagtggaag agtataataa tcaaagccag cgacagaaac 1920 gtggcaaaga cattcaggcc aggacctcct gcgatgtcgc caacacgagg cacgagttgc 1980 atttaatgaa gctgctggtg ggaatggcgt tggcggtgtg cagattgcat tatgtctcag 2040 atatttcgat caaagctggc aaacgtaagt aagcccggat agaaaaatgg aatcgctggt 2100 gtctatgggc cggcagggcg gagcggagct ccatcgttag acaatttaat aagcgcggcg 2160 cctttgtagc cagcctggcc aggacgaacc gctggcgcag acagggaagc ccagaaacaa 2220 tgccagcaag atggcaacgg aagcttccaa agcctttgca ggcgccggag caactgcagc 2280 ataagaattg cattaggggc ggcaaacgag cgctggtgaa tttcgctttg acttagttcg 2340 gatctggaaa catctgccga cacattgctg tcctgcaatc tgcactgaaa aaaaaaacaa 2400

129 aatatattta ttcaattatt tctatactta aagtaaaagt catcaagttt aaagctaatt 2460 gtataatttt tttctttcga ttttttcgat tgagcaataa aatatggttc atatatgtta 2520 atacttacat tttttttaag ctaagtaact tgaagctagc tacacaaata ttataacata 2580 ccagacagga aatggaaaag ctatttccgt gactttcaaa ggcgttgctt atttcgttgc 2640 tccatttatg tgagtgcttc ttccggtggc agttaaacgg tatttcttcg attttcgaaa 2700 acgaatggct gatttgagga ctgcatttat ctgagtgctg cttccgcctc ctgctgccgt 2760 cctttttgtg ccaacccctg cagatgttgc aacactgatg acagttttgt ttgtgcgctt 2820 tgggagccat tacaaacaca aacacaaaca caaacacgag cacgggcacc aatacaagca 2880 gaaagggcga cgcacacaca cgcaaacaca cacctggagc aatccttggc aaagtgggca 2940 atgtagcaag aaggaggacc aacaaatggc tgcttgttat atcaagtgtg aaaaatattg 3000 cagtggcagt gacaggagca gttgttgctg tagttgcacg ggcacacgcc cgccaactgg 3060 aggcaagaaa ggacgaaatc gggatttgcc tgctgtcaag ggctttgcag agggtcctgc 3120 gacagaagct gaaatctcca gcgaacagca ggcattagat cccaaggatt aagctcttac 3180 aattcaaagg cacaatggcg caagtagcaa ctggatatga gtaagccgtg cagtacatta 3240 attgcatcgg ttacgtaagt aacatgtggc atacaatgtg gcattgaaat ggcctatata 3300 ttctattctc tgttgataag tatgcaaatt caactttcaa tgaaagctga actaatatgt 3360 tcatgaccaa taggcgtatg agtaatatta gtagactaaa tgtttaaaaa cgctaaaggt 3420 gtaatatcaa aattaatcta acaaaatcat tcatggcttt ggttgttgac tttctggagt 3480 gtaataataa tacaaattta aattttcgta aaaacaattt gatccgtacg tacacgcaca 3540 aatctaacaa actattgaaa tggaatcaaa tagctgaaat aatatttata aatgaatata 3600 tatttttagg acttaagttc actgaaggct tagcgggaaa taagttttta aggatgaaat 3660 attaatgcta ttatgctaaa ctctgttgag tttccagatg catatatcct ttgattttga 3720 actttcaacg aattttccac ttgatcaatc gaccttttgg aaacgaaaca agacccatgc 3780 aattaaacga catgcgttga tgccatttta agcgcttgca cttgcagtga attatgatta 3840 cgcgtggaaa acataattaa tgcataatta atttcatttt aaaatcagca ttaaacgcca 3900 gttaattaat aacagtaaac gcaattactg catagcatag ccatcaaaag ccataaaaaa 3960 gacagtaaat tgaattacaa cgtcccgtca atggtcgtga atatttaagt aaacgcgaaa 4020 agctcgcaaa tgtttgcaac ttaataaatt atacttggga cgaataatga taaacaagag 4080 aacagccgca aatataaaaa gaaaagccaa gcgaaaaaag gcgcgaggca cgagaagctg 4140 gaaaattaat tgagcgcaaa ttggtgaagc tg 4172

<210> 95

<211> 1014

<212> DNA

<213> Drosophila

<400> 95 atggaagagg atgtgtatgc ctcgctaggt gcctacaacg acagcggtgg cgacgattgg 60 agcagctcgg agcacctggt cctgtgggag gaggatgaga cgcagcgaac gactgctaat 120 gccaccagtc ggcataatca actgcatgtg gccaggtgga atgccaccgg caatgcgacc 180 atcagcgcga ccttcgagga cgtacccttc gatgcgaaca actactgggc cctattggcc 240 ctcgtcctcg tcctgggaac agcggccggg aacatccttg tctgcctggc catcgcctgg 300 gagcgccggc tgcagaatgt gaccaactac ttccttatgt cgctggccat caccgatctc 360 atggtcgccg tgctggtcat gccgctgggc atccttacgc tggtgaaagg tgagtccttt 420 gtcccattca aagtccggaa cagagtggaa gagtataata atcaaagcca gcgacagaaa 480 cgtggcaaag acattcaggc caggacctcc tgcgatgtcg ccaacacgag gcacgagttg 540 catttaatga agctgctggt gggaatggcg ttggcggtgt gcagattgca ttatgtctca 600 gatatttcga tcaaagctgg caaacatgtt gcaacactga tgacagtttt gtttgtgcgc 660 tttgggagcc attacaaaca caaacacaaa cacaaacacg agcacgggca ccaatacaag 720 cagaaagggc gacgcacaca cacgcaaaca cacacctgga gcaatccttg gcaaagtggg 780 caatgtagca agaaggagga ccaacaaatg gctgcttgtt atatcaagtg tgaaaaatat 840 tgcagtggca gtgacaggag cagttgttgc tgtagttgca cgggcacacg cccgccaact 900 ggaggcaaga aaggacgaaa tcgggatttg cctgctgtca agggctttgc agagggtcct 960 gcgacagaag ctgaaatctc cagcgaacag caggcattag atcccaagga ttaa 1014

<210> 96 <211> 337 <212> PRT <213> Drosophila

130 <400> 96

Met Glu Glu Asp Val Tyr Ala Ser Leu Gly Ala Tyr Asn Asp Ser Gly

1 5 10 15

Gly Asp Asp Trp Ser Ser Ser Glu His Leu Val Leu Trp Glu Glu Asp 20 25 30

Glu Thr Gin Arg Thr Thr Ala Asn Ala Thr Ser Arg His Asn Gin Leu 35 40 45

His Val Ala Arg Trp Asn Ala Thr Gly Asn Ala Thr He Ser Ala Thr 50 55 60

Phe Glu Asp Val Pro Phe Asp Ala Asn Asn Tyr Trp Ala Leu Leu Ala

65 70 75 80

Leu Val Leu Val Leu Gly Thr Ala Ala Gly Asn He Leu Val Cys Leu 85 90 95

Ala He Ala Trp Glu Arg Arg Leu Gin Asn Val Thr Asn Tyr Phe Leu 100 105 110

Met Ser Leu Ala He Thr Asp Led^{" "}Met Val Ala Val Leu Val Met Pro 115 120 125

Leu Gly He Leu Thr Leu Val Lys Gly Glu Ser Phe Val Pro Phe Lys 130 135 140

Val Arg Asn Arg Val Glu Glu Tyr Asn Asn Gin Ser Gin Arg Gin Lys

145 150 155 160

Arg Gly Lys Asp He Gin Ala Arg Thr Ser Cys Asp Val Ala Asn Thr 165 170 175

Arg His Glu Leu His Leu Met Lys Leu Leu Val Gly Met Ala Leu Ala 180 185 190

Val Cys Arg Leu His Tyr Val Ser Asp He Ser He Lys Ala Gly Lys 195 200 205

His Val Ala Thr Leu Met Thr Val Leu Phe Val Arg Phe Gly Ser His 210 215 220

Tyr Lys His Lys His Lys His Lys His Glu His Gly His Gin Tyr Lys

225 230 235 240

Gin Lys Gly Arg Arg Thr His Thr Gin Thr His Thr Trp Ser Asn Pro 245 250 255

Trp Gin Ser Gly Gin Cys Ser Lys Lys Glu Asp Gin Gin Met Ala Ala 260 265 270

Cys Tyr He Lys Cys Glu Lys Tyr Cys Ser Gly Ser Asp Arg Ser Ser 275 280 285

Cys Cys Cys Ser Cys Thr Gly Thr Arg Pro Pro Thr Gly Gly Lys Lys 290 295 300

Gly Arg Asn Arg Asp Leu Pro Ala Val Lys Gly Phe Ala Glu Gly Pro

305 310 315 320

Ala Thr Glu Ala Glu He Ser Ser Glu Gin Gin Ala Leu Asp Pro Lys 325 330 335

Asp

<210> 97

<211> 9268

<212> DNA

<213> Drosophila

<400> 97 tataaatgaa ttctgaaaaa tgtataaaat gaaatggact catcattagg tcaatttgtt 60 tggaatcaaa aatttcccaa agaaatggtt ttacatttca gaaagtgacc cttaattttc 120 gccatcaata tttattagaa cattgacctt aaagcaattt gtatagtcgt cactttaaca 180 gatcaaagtt atacttaaag tcgtgcagtt gcaactgaaa ctgattcatt ctacgcctta 240 tcgatccatc ttcccccgaa cttatcccaa tttctgttgg ctatctcgtt aggaaattcc 300 ttttcccagc ggccatacgg attcatgttc gaccagattc tggattcaca aatcccgcgc 360 ccaaatctca gggcacacgc aacaacacag taaacacaag tatcactcac cgaatgtgtg 420

131 ggagattctc ggccacacaa gctacagaga aacaaaccca attcaaacta aaaatttcta 480 aatggaaaat aaattaattt tattagttct ttataagata ctaagactta tactagttgg 540 aaatcttcta ggcatggttt gtaaatcatc cttatatctt tcgatattat tctaagactt 600 ttttcgtagt gcacacacaa ttgtattttt atgggaatag ggcgagagtg gtgcgctgag 660 ttatgacgtc caacagctgt gcaaaacgat ggccacagca tcgggaatag ccgctcatat 720 gtgggccagt tggcctgaaa tatgttgcat aagctccccc ctcttggcaa tatcatttgg 780 cagctcacga atgaactgtg gctcccggga aaatatggcc aaaaaaaata aaaaaaaaaa 840 ggcggggagt attaaataaa aatggctaga gaacattgca ttgtttgccg ccgaccaagc 900 caatcgtaaa tcgtgtgtac acataggtag aaagtattgc agccacttaa tacagtcata 960 agtcggccat ggaacattta caagctgacc aagaaataca atgaagaatc ggtttttttt 1020 ttcttttaca ggctactttc ctttgggctc ggagcactgc ctcacctgga tctgcctgga 1080 tgtactcttc tgcacggcca gcatcatgca cctgtgcacc atctccgtgg acagatattt 1140 atcgctacga tacccaatgc gatttggccg gaataaaaca cgtcggcggg tcactctcaa 1200 aattgttttc gtttggcttc tgagcatcgc catgagcttg cccttgagct tgatgtactc 1260 caaggtgagt aataatgcta ttcttttgtt tatattctat attccaacaa tgcgtcaaaa 1320 tatagtaccc ttttggcatt ctatttccct taatctaata gtgaaaaccc attaaattcc 1380 ctagttaacc tagtactcaa aatctaaagt gaaaattaca aacactgtgc caagtcaata 1440 attaaaatcc aaagcgagac aagtgtctga aatattttgc gcatacatat gtcctttact 1500 tacccaaatt aattccgtgc tcgccctgct atctttcctt tgattccaga atcacgcctc 1560 ggtgctggtg aatggaactt gccagatacc ggatccggtg tacaagctgg tcggctccat 1620 tgtatgcttc tacattccac tgggcgtgat gctgctgaca tattgcctga ccgtccgact 1680 tttggcccgg cagcgccaga atctgggtgg tggacagcag acggcggcgg ccactcccgg 1740 atgggccagt ggatggctcg gccaggcacc ggccttgggt aaggatgcta gacaccacac 1800 ttctgacccc cactctcacc cagaagtgtc cacgaagagc tgctgcttct gctgcagctt 1860 aatatgattt tcagtttgcc taaaatttgc attttgttct ccggattgca ctttttgcac 1920 tgaaaacttt acacgacact cgacaaaagt agagagtagg aaatgggcgg atcaggatca 1980 gcaaggggaa agtgctcaaa agtggggagg ggtgacaaca ctagacaaac aatgcagaga 2040 catgtgccgg atactccccg aatccgtgtc cctgggcttt ctggagccca aagtgcgact 2100 aagccgcagc aatgcacaca aaatcgacat tgtcgtcgac attgaaccgg atggaatggg 2160 gcgggggggg gggggggcca acaccccagg acaatcaccc attccaccca cttgcacaca 2220 caaccttaca aataggatga aaatccagcc catatgtgta gatagctaat ttccacgttg 2280 ccatgaatcg agggccagct acgtaaatgg cttgtaatgc tctaagagct cttccatagt 2340 gctcgactag ttttaaaacc gaagttttaa gcaccaactt ttcaacgaag cctcgttaca 2400 gccccgttgc gtagggtagt ttttaaaaac tcaagagctg cgttaacttt tagttttatt 2460 aaccactttt tgaaatttcc ataacacttt tcagcgcatc tacaaaaaag aggaggaatc 2520 tttaaacatg tagctaataa ataaaaagtg aacagtctgt tattttagat ttaaagagtc 2580 taaattgctt cctgcatccc taattacccc tctcgttact agcccagtta actggagctt 2640 ttggctaaaa acaatccaag atccttcgct tccattatcc cttcacaatt caatagacca 2700 gattcaattt attttaagca taactaagtg gctcctaatg ccattgtctg cccgcagaat 2760 ttattcagcg ctcccatttc tcatccaatt ggattgcctt gagccccaaa ggggacagag 2820 agtaattttc tgggggacaa gctgtggatc tctggatgtt gaaagtcaat acagttgggg 2880 aatatttaat ggaatgcttc tggtggtggc gaatggtgaa tgctgaatgg taaatgctga 2940 tggtgatggt gactgcagtc gaatcgcgtg cactgcaggg catttttgcg aaaatcgtag 3000 cgtgcattta ggggcgattc gcaggacgcg gtgtccccga ttcgtctaag tggatttgaa 3060 gcctcagctg caggcattag ggtgtgtatg tatgtatgtg tgggtgcgca tctgtgagcg 3120 gccaagtgcg actgtgttag tgccgtggat ttgggcagtt attttaagcc aaatctctgc 3180 tgtaaagcgt ccgcatttcg gtcaggcacg tagtcggatt tgccgtattg tactttttac 3240 acgcagagaa aaatcttcgc atttattaca caaagaatca atgtgtctga ttaatataag 3300 caagatattt aatgcaagtt agaatagctt caagcactat ttcataaggt ctgaactgga 3360 ctaggagaag aatttctctc agtgcctatg ttgaaggggc atttaagtgt gctcgtgcga 3420 gtttattagc gaatttgtga cttttcgtag cgcactattg gactgaatgc aatttaatgg 3480 aaactgtata tccgtttaac cccgtgttcg tgctccacag aacgacgatg cacctggcgg 3540 cgccttttga aaccgggtcc aggtaacgcc tcctcggtgc tgcacgcaca ctcggccaat 3600 tcaacggata cggatctcag cactttggac aaccacgagc tctggctgcc cgattccagg 3660 tgagctatcg agtttgcgag ccagtgttgc agtgcaaatt accatatata ttattcatgt 3720 ttatgtagca taaaggagcc aacgcccacg accatgacgg ccttgcatca gttcggtgcc 3780 gagatgctga aactatcccg aggcctggag tcggtggcct cgtcatccac caccggctca 3840 cccaccaaat ccgaattttc cctatcgaac cacctgcagc tgcagtaccc cagcagccca 3900 cagcgatatg ccgccaccca ccagcagtcc caccaccaca accaccagca gcatccggcc 3960 ggagtttacc accagcaggc atcgcccaaa ggtcgccacg gaaccacagt tctgggtctg 4020

132 tccaccacca cgctgggcat cgagcgggag agcaccagga attccctggc cagcagtcgc 4080 atgggcggcg aacagagcga tgggtgagtt cataaatagt aatataaata agtgagtcca 4140 aataatgggg tctaaaaata tactatctaa aagtctggaa gccaaccaaa attatggtta 4200 caattttctc aagatgtaat atgatgctca aacataatta aattgcttca ccacttaacc 4260 agaatctctg ttgtcacaaa taatattaac acagacaatt aaattctttt aactttatcc 4320 cttttgcggg ccacaatttt cactagaatt gtgtcaaatc ccttgaaaag catagacaat 4380 tcgggcaggt accttggaaa aacgtaaagt tttcgtggct cttcacctga caaaaggaca 4440 aacagctgcg atgggcaaac cgttttgcca gagtgatcct ttctagtcgc tcgcaggacc 4500 ttttgttgtc gctgtctcag ccggttttcg agtgccagta ctgcgcttgg ccaagtgtgc 4560 tgaccacacc aaaagccaag aaaatgctca cctcgagtcc tttttgtgac tcgtttactt 4620 tctccttttc catttattta gttttctttt ttcgttagct catttttgtg gcattgcctt 4680 ttattgtcct tccgccttcg acttgttgtg aaatttttcg taataattaa ttttttttcg 4740 ctacgttatc ctttttcttt gtgtcggtgc aaactgtttt atttcttttt tttggccaaa 4800 aggcagaggc actgcctttt tatttggcat tcgagccgct caagtgattt tggcgtcgac 4860 tgaggccttt tgccaaaatg tgtttttcat taatttccta aatttagtct actggcttat 4920 gctgggataa gtgatgcgac gagaaattta attaaaaaat tgagataata gaagacgaat 4980 atattttgaa attaccgaga atttaataag aactggaaac atggctaaac tggcatattc 5040 aagtaaatag ggcgcttcat gtttatgggc attcaggtgg aactaatatt aactatttaa 5100 ttgcgtatga tatgaaattc tatggaagag cctggcaaat tctaaaaata cttttatttt 5160 aggcactcaa cccaattcga tattgtacac gcattttatt ttgatttaat tggttatcat 5220 atttagtctg caaaatccat ccaataaaag catgaatttt tcactgcaac tgcgaacatt 5280 gatatcttga atcccccgtt cgattttaag cttgaataaa aggcagctca acttgcgaaa 5340 tgactgcaca ttttatctcg ctcatatttt tcccatttaa ccaatccctt atgcatgttt 5400 atatcatata tcattgtgac tgtgcgcctt tcagccaaat gcttggtatt gggtattggg 5460 agcactatgt gccacattgt ttgacagttg aacgaatttg cacaatcaat aaaatggatt 5520 tggctttggc tccggcttcc tattgtccgc aatggatggg atgccacttg gcataaagga 5580 cgaaaagaaa cgggacgagg tcaaagtcga gtggttttta attgttgcac aatttgccgt 5640 ctcatgcggc aaagttgaca aatgatgctg gcgatattct aatttttgaa cttggctggg 5700 agacttaaaa tcagctcaac acttcgccac ataagagtat atattatatg tatgtgtatg 5760 cgaaggcggt atcctgcgat gtcctgatga gcttggcagc tgtttaattc ctttgtgagg 5820 gggaaacaat aacaaagttg gcatcagctc ggctttgttt cacttgcata atgagtagct 5880 ggccccaaat accacctccc cactccccca ttgcttagcc ctgttccaac gcatctcaat 5940 ttatgcgcac gtctcgtgca aacaaatcaa aaacgcgaag gatgcataat gagctgacat 6000 ccttatcctg cgtcttggca gcaccgagca tcccgatccc tgtcctccct gcagccacca 6060 ccacttggcc ttctgtctgc taacgccttc attagcagct aaccacgccc ccaacgccac 6120 cgccccacac cgtcttggcc aaataaagtt ggcgcgcatt tgcatgcagg gcaaaacggg 6180 cggcaggaca gaaaaccgca aaggcagctc gcaaatttat gcgctttatt aaaatgaatg 6240 caaaatgagg cggtacagaa aaaaaatcga tgtacaatat gtttatatat aactttaaat 6300 taaagctaca catatgagct aagtatttct gcaattaata atataaaatt aaaaaaaaaa 6360 aaaatcccgc cagtaaagta cagtaagccg aactaacata ccaaatataa tatagtaaat 6420 aataatgcaa gaatttttca agtgtaccac aaacaacgga gcaagaaaaa atgttagaag 6480 gcggtaaacc acaaagagca aacacaaaaa atgttgccta cttcccggca aaacaggtga 6540 aagaaacgag ctgaccacaa agcgtgctgg cttttgttca attgccgtta gcgagtgttc 6600 actgcattgt tttaggcacc tcaccttcga atagagtttt gccaattggc tgcgcaattt 6660 taattaaaaa tgtacgacgc cgaaggggag aaggtgaaag aaaatggctc ggcattgggt 6720 actaaatcaa taaatcggtg gggtatgaca tagacatatt ttatatattt tcattattaa 6780 aaccacatgg ttccttttgt tctagtctgc tttaatttga ttcaggaaaa tcgtttaata 6840 gaccactttt ttaaaatgaa atgaaaataa tcatttaagg actttgactg tagtatgtca 6900 ttatatttat ttaatcagta aagttctttt cctttcagga ctctttcaca gctttcccaa 6960 cgattgcgag cgtataaaaa gcgacgaaga gcttcgtcag ctgttcctgg acgtgagaaa 7020 cgtgccgggc atgaggacgc agacgaggat gtggaaacgc ccacgtcaac gctgcgccgc 7080 cacaagcgcc ataacagtct gcccaagaac gcactctatc cgcgacacac cactgtacag 7140 gagagcctcg atgacgacga cgacgaggag gaggagagcg cgcaacagaa ggatcagcag 7200 acgaagtcga agatctgcca ctcggacact gagctagatc ctccgcagaa ggcgaagcag 7260 tgccacatag ccgggcagaa tcatcagtcg gactacctgc agctgccctc ggtttgcact 7320 tgtccgtatt ttggggacag accgctccag aattgtgtga aatcggcgga ggtgaagatt 7380 atttcgtccg ccttccgagt gaccaccacc acgacggcgg tgagcagttc gcccagcgag 7440 atggagctac tcatgtgcag tagtggcaat aaaaagtcat tgacctccag tgtgagtgcc 7500 ggcataacag gtggaccggc aggagcggct ccagccacag ttggctccac cctcagtcca 7560 cactctgctc acaatcaggg cagctcgctg acagttcaga gcgatggtag tgggtacttg 7620

133 gctgctccgg gaactccttg tcctggccga cgaaagttga gcatctcaaa gaccgcctcg 7680 gtggtcacgt gggattcaag tcgtcatcgt cggcggggca gcagttttgg cggagtgcga 7740 acatccctgc tgttgacgcc caccaaaaca gcgaccacct ccaactcatc cacaccgttg 7800 agaagatcgg ccaccttgag gagtcaccag aatatgaact accagggagc gggcgaatgt 7860 ggtggcaaga ccaggacgac aacatcctca ccctgcatgt tgcagcgtca gcagacggtg 7920 cgatctcatc actcgcggaa ctccagcgtg atctccagaa actcctcgcg ccacggcagg 7980 atcatcaggc tggagcagaa ggccaccaag gtgctgggag tggtgttctt tacgttcgta 8040 atcctctggt cgccattctt cgtcctcaat ctcctgccca cggtgtgcgc ggagtgcgag 8100 gaacgaatta gccactgggt cttcgacgtg gtcacctggc tgggctacgc tagctccatg 8160 gtgaacccca tcttctacac catcttcaac aaggtgttcc ggcaggcgtt caagaaggtc 8220 ctgctgtgcc gctattcgag cacgagtgcc tggcgaccga gcagataaca gacgcccgtt 8280 aaaccgggca aactgaagac gaatacccac aagtgcgcca gtgtggattt tcaggattcc 8340 actgctccgg tgcggggcgt tctgaaaaga agtgtggcag tggcaagtga catataaata 8400 cggcaaaggc cggtcatttc gcctgcggtc caccgcacaa cgtgtcgtat acgcaatctc 8460 gaaaggacga taatgcccac ccgcactcca caccacgcac tccgcactgc tcacacgtgt 8520 gtccttgggg cttaaattct tatgtgcctc taattaattt caaattcaat ttgcatgcca 8580 ttgaaaacac atgtcccagg cgtaagaagt ggggccaagt gaattagata ttgaagtgga 8640 gtcggatccc cgcaggattg ccaagggtcg gggattaaac tagccacaga caacagcata 8700 acgagcatgc tactcacccc tggtggttcc ttccatttcc ctcagctctc agcaaacggt 8760 gaagatgcac ttaattgcgg aatgtttgct ttcgagcaac gtaataccgg caaacacatt 8820 tactttatag caacgctctt cagttatcga caaagttctg gctcaccgaa agttcatgtc 8880 aatctgttga tatttgatag cattttccgc gaaattcctt ttagattcac tacgtactcg 8940 aaaataaact tgaaaattca cgtaaattta aagattgtat atataaagtt caacttttga 9000 aattcttaaa aataaagcgc caatgtcgct tcgcaaactt cgatcgataa acgctatttg 9060 gtttggcatt tggcaattat gcattaaatt tatggcaaat tcactgcccg ccaatgcaca 9120 aagaatttca tcggtatcca ttaaagaaac cgacacgtac acaaatccac ggcaatttgt 9180 gacttttgtt gtttgtttgt gtggttggac cggcagattg ctatttttat ttgaaaagtt 9240 cattcatttt gttttatttc tgtggcca 9268

<210> 98 <211> 1251 <212> DNA <213> Drosophila

<400> 98 atgaagaatc ggtttttttt ttcttttaca ggctactttc ctttgggctc ggagcactgc 60 ctcacctgga tctgcctgga tgtactcttc tgcacggcca gcatcatgca cctgtgcacc 120 atctccgtgg acagatattt atcgctacga tacccaatgc gatttggccg gaataaaaca 180 cgtcggcggg tcactctcaa aattgttttc gtttggcttc tgagcatcgc catgagcttg 240 cccttgagct tgatgtactc caagaatcac gcctcggtgc tggtgaatgg aacttgccag 300 ataccggatc cggtgtacaa gctggtcggc tccattgtat gcttctacat tccactgggc 360 gtgatgctgc tgacatattg cctgaccgtc cgacttttgg cccggcagcg ccagaatctg 420 ggtggtggac agcagacggc ggcggccact cccggatggg ccagtggatg gctcggccag 480 gcaccggcct tgggtggacc ggcaggagcg gctccagcca cagttggctc caccctcagt 540 ccacactctg ctcacaatca gggcagctcg ctgacagttc agagcgatgg tagtgggtac 600 ttggctgctc cgggaactcc ttgtcctggc cgacgaaagt tgagcatctc aaagaccgcc 660 tcggtggtca cgtgggattc aagtcgtcat cgtcggcggg gcagcagttt tggcggagtg 720 cgaacatccc tgctgttgac gcccaccaaa acagcgacca cctccaactc atccacaccg 780 ttgagaagat cggccacctt gaggagtcac cagaatatga actaccaggg agcgggcgaa 840 tgtggtggca agaccaggac gacaacatcc tcaccctgca tgttgcagcg tcagcagacg 900 gtgcgatctc atcactcgcg gaactccagc gtgatctcca gaaactcctc gcgccacggc 960 aggatcatca ggctggagca gaaggccacc aaggtgctgg gagtggtgtt ctttacgttc 1020 gtaatcctct ggtcgccatt cttcgtcctc aatctcctgc ccacggtgtg cgcggagtgc 1080 gaggaacgaa ttagccactg ggtcttcgac gtggtcacct ggctgggcta cgctagctcc 1140 atggtgaacc ccatcttcta caccatcttc aacaaggtgt tccggcaggc gttcaagaag 1200 gtcctgctgt gccgctattc gagcacgagt gcctggcgac cgagcagata a 1251

<210> 99

134 <211> 416 <212> PRT <213> Drosophila

<400> 99

Met Lys Asn Arg Phe Phe Phe Ser Phe Thr Gly Tyr Phe Pro Leu Gly

1 5 10 15

Ser Glu His Cys Leu Thr Trp He Cys Leu Asp Val Leu Phe Cys Thr

20 25 30

Ala Ser He Met His Leu Cys Thr He Ser Val Asp Arg Tyr Leu Ser

35 40 45

Leu Arg Tyr Pro Met Arg Phe Gly Arg Asn Lys Thr Arg Arg Arg Val

50 55 60

Thr Leu Lys He Val Phe Val Trp Leu Leu Ser He Ala Met Ser Leu 65 70 75 80

Pro Leu Ser Leu Met Tyr Ser Lys Asn His Ala Ser Val Leu Val Asn

85 90 95

Gly Thr Cys Gin He Pro Asp Pro Val Tyr Lys Leu Val Gly Ser He

100 105 110

Val Cys Phe Tyr He Pro Leu Gly Val Met Leu Leu Thr Tyr Cys Leu

115 120 125

Thr Val Arg Leu Leu Ala Arg Gin Arg Gin Asn Leu Gly Gly Gly Gin

130 135 140

Gin Thr Ala Ala Ala Thr Pro Gly Trp Ala Ser Gly Trp Leu Gly Gin 145 150 155 160

Ala Pro Ala Leu Gly Gly Pro Ala Gly Ala Ala Pro Ala Thr Val Gly

165 170 175

Ser Thr Leu Ser Pro His Ser Ala His Asn Gin Gly Ser Ser Leu Thr

180 185 190

Val Gin Ser Asp Gly Ser Gly Tyr Leu Ala Ala Pro Gly Thr Pro Cys

195 200 205

Pro Gly Arg Arg Lys Leu Ser He Ser Lys Thr Ala Ser Val Val Thr

210 215 220

Trp Asp Ser Ser Arg His Arg Arg Arg Gly Ser Ser Phe Gly Gly Val 225 230 235 240

Arg Thr Ser Leu Leu Leu Thr Pro Thr Lys Thr Ala Thr Thr Ser Asn

245 250 255

Ser Ser Thr Pro Leu Arg Arg Ser Ala Thr Leu Arg Ser His Gin Asn

260 265 270

Met Asn Tyr Gin Gly Ala Gly Glu Cys Gly Gly Lys Thr Arg Thr Thr

275 280 285

Thr Ser Ser Pro Cys Met Leu Gin Arg Gin Gin Thr Val Arg Ser His

290 295 300

His Ser Arg Asn Ser Ser Val He Ser Arg Asn Ser Ser Arg His Gly 305 310 315 320

Arg He He Arg Leu Glu Gin Lys Ala Thr Lys Val Leu Gly Val Val

325 330 335

Phe Phe Thr Phe Val He Leu Trp Ser Pro Phe Phe Val Leu Asn Leu

340 345 350

Leu Pro Thr Val Cys Ala Glu Cys Glu Glu Arg He Ser His Trp Val

355 360 365

Phe Asp Val Val Thr Trp Leu Gly Tyr Ala Ser Ser Met Val Asn Pro

370 375 380

He Phe Tyr Thr He Phe Asn Lys Val Phe Arg Gin Ala Phe Lys Lys 385 390 395 400

Val Leu Leu Cys Arg Tyr Ser Ser Thr Ser Ala Trp Arg Pro Ser Arg 405 410 415

<210> 100

135 <211> 8877

<212> DNA

<213> Drosophila

<400> 100 gacctttaag cagactaagg ggttgaggca atcctttttt cccaactcgt gtcaattaac 60 tcattaaact tcccaccgtt ttgtggagcg tcggacccaa ttagctttca attataccgt 120 ctatgggctg gtttttcata atcaagcaaa atttcaatta attaaaatgt aaccgagcta 180 aaatggaggt gtgagaaaga gcctttatta cgaaggactc tattacacat taaagtttta 240 tggaaagaat gaatattctc agtgagcaag accagataag ctgccaacat attttctcta 300 tcctgtcagc ttcataaaat gttggttttg atgatggaaa cttttgccca tgaaactttt 360 tgttcgcaga ttatcgtgaa agagttttga gctccgtttc gctgtattgt tggcttgcca 420 aactgttgca tacttttagg aagttgcaag gagcggaaca tgtgtttgcc atgtcaactt 480 tttgccatat ttgtagccat aacagctaca catctccgag gaaggtattt taggaatttt 540 ttttgagtac atcaaagccg ataaagaaaa tcccccagac aatggaagct taccgaaaga 600 aaaccgcaat gataattccc cagagaaaaa cgccgatcga gtacactgaa gtaaatagac 660 catttattta gatgctagaa tttcttgttt atacagagaa ttaatccatt tgcacattga 720 gttacattca acagctacag ttggagttca tagcatggag ttggttggat tgttaatggg 780 gctctcagct gctcacatat acgacattta acagtttaaa acgattgacc taacttatgt 840 tgcttgtttg ctccgcttgg tacttggttt cgtcctttca tcgcactcca gcctttaata 900 attagtacta gctaactaat cgcactcgca gatctgcgac acggaagtgg aaagttcaat 960 gaaagttcag tctcttaaga tgcacttgct agggatttgt ctacaccgag ttctcctcga 1020 gtccttgctg gaattcgaga atgattattg gatggtctgt atgagtgaga agagctgaat 1080 tctggttctc accctcatca ggggactaat ggcccggggc attacgctca gagtgctgcc 1140 ggaactcatg gcatttgccg ccaaagtggg catcgtgtgc agggcattgt tggagccccg 1200 gtggagtgaa agtggggcat gctgacccac cagcgtggtg gtggtggccg aacttacgca 1260 cgattcccgc ttgccacgcc catagtagct ggtcaaaggt ctgcaacgga gtggatgtca 1320 agatatcccg tcacttctta gccacgattg ccacataact taccgcatac tctcggctcg 1380 gggggaacca ccgcctttcg agaagctttt cgtggtataa ctgccaagtt tacgaagaaa 1440 tgcgcagaaa aagttagtgt acaatagtga aaatattttt aatagctgcc attcctagta 1500 gcaatctagc attgccacac tttatgatag gtttaacatt aaaggcattt gaggagaaat 1560 atgtacaact tagttgtttc ctatataagt ttgcagtttt ctcttctcga gtagtgtatt 1620 tattcttaag tgtacttaca agcagactta aaagtttgga ctacttaccg tcggttctgg 1680 ttaagctgaa tggtgcgcgt gtcccgccac gtggaaatgt ggtgtctcag tgcatttcgc 1740 acctccgagt tgaggaaaca gtagaacagc gacaccgaga atccctgtgg cacacacaca 1800 aacagatctt tagaaaaaaa gtggctaaga ggattgacaa acgaaaccca cctgagtgct 1860 gagtaatacc gctcgcagga cggcaaacat gtgtcccatt aggccagatt ccgagggacc 1920 agccagcacc accaggtagg tgatgccaaa aagtgggatt agcaccagca gtgccttagc 1980 agctttccta tactgacgag tctccactgt attggccgag cgcagctttg tgattagaac 2040 ctaaaagaga agcaacccga taatctggct cagtattttc ggcaatttac agtcggaaaa 2100 atgtcggatg ataaattgta aattcataca atagctttaa agtgtttcaa gaaactaatt 2160 gggtgattca taaatgtgag tttttgcatc catgttaact tgttcaatct tctctgatgt 2220 tctttttttc gcatatcaat attttttctg tgtaaattcc atacgcaccc acatgatacg 2280 cagcagaaat gtgagattga ttattagcac cgcacagaca ggtccctggt atatccaatc 2340 cacatgggtc tcctgcatcc aggggcagtt gatttcgtac tgtcggatgg gaaacaaaag 2400 gaagactact ctccaggggt ctcttcaaat cccaaaatag acataccttt tcgggggtgc 2460 tgtaggtgac cgtcagactc ttggccacag cccaggtgac aacaaacaag gccgggccac 2520 ctgccagcag gagaaagact taattggctg gcacacacaa tcgggcattc acacttaccc 2580 cagcctatgg aggcgtagat attaaagcgt aaattgtccc cggagaaagt cttaaccacc 2640 agcatgtaca ggtacaaacc ctcgaccagc atccaaaaga agttggtcag ggtgaagaag 2700 tggaacaggg tgatcagagc aatgcagctg cccactccac ttcggatgga gatctgtaga 2760 ttaagtggta gccattagtc ttaagctgtc agcgtctgtt tatagtttcc tttcactttg 2820 gactagcacc cctttcaggc acgagtatga tttaataagc cagcaattgc aattatctgg 2880 cagtctcata atgctcacct ggacggataa caagagtatc cagaacaaag ccgacatgat 2940 gtacgtgaag aacaagttgg cgtggatggt gttgcgcagg caacgcagct ccctggtgaa 3000 caaagacaaa tacaaaggac ggggggtaag tcgggggtta ggcaaaaata aatgccatac 3060 ccagggtatc ggggtcacca gggagggggc tggggtgggt acactcactt gaagtaggcg 3120 aaaacaatca gcgccagcga gagcgatacc aggctgaggg tgtatccaat gtagtagata 3180 atggtgggca gctccacgat gacctcgaac tccggcacgg attctggggc gggcaggtgg 3240 gcgcaggcat cgtagttggt gtacttctcc caagttccat tggcgtggca gaacctcgtt 3300

136 gcattctctg gtcaaataca aaaacgcacg cagcgaaaaa tgcaaacagt ttttaaatag 3360 actagtccta tacacttgga tctatattgg gaatatgcct tctctgtttg gacatcgact 3420 taaaaaattc caatttaaat tcataactta gtgcaaagct aacagttttt ttcaaacgct 3480 tagtttaaat ataagtctaa tgttaaagta taaggtcaaa ggggtactca ctgctgctat 3540 cgtaatgaat tccctgcaac tcgtccatgc actggagcac cgccagggta ccgcgagctg 3600 tcctcggcca gcacaggatc gagtcgaact gggtgaggca gtggccacta tcgttgccat 3660 aggtggatgc ctcgatgtgc tcctgcacca ggcactgcaa ctccacgctc tcaccgatgc 3720 catctaggtt gtgcagatcc aggagcggat cactcccgct ggcgttcacc gaatcgatgt 3780 ggttgtggtc actcattcta caacatcctg gcacttggca tctctggtac tgaaataagt 3840 cagtttaaag ttgaggcaaa gattgtaaaa tacttgaagc agtgggaaaa tttaaaatat 3900 tttagaatca ttatagagtt ttaatacatt tcatttaaga accgtcggac aataacgttt 3960 tagaaaaatg gtaagcttta atcggaaata aaatattata gactgatacg aaaatattgc 4020 tgtcatttcc tgaccatttc cctacgaatt gacaacgttc ataatactcc ccagctgaat 4080 tcgttcaatc agaaagttat aatttcctca attgttaggg gattccccgg cggttggctg 4140 aaactaagct gtcgggcaaa gttcaattgc caacccttct gctcgctcca ccgcagccag 4200 tggcatttcg cctgtgtgcg ttaattgcat tggccatgtt tcaccgacaa cgggccacgc 4260 ccacatcgaa ctcggcttaa agatccatca actcggcggg aagtatgctt taagccaaag 4320 accatttcta gggaaaacag ggtggctaga gataagtaaa tgcacaggcc cagtgccata 4380 aaaattcatt agttttgcca tcaaaggcgg acagaagcgt cagcaaatca gagaagcggc 4440 aggcaacctt ttattctgat atgtgcccat aaaaagcacg tcaaaggacc caagtctggg 4500 gtgatggtga tagaaattag aaaagctaac ttccggccaa agattgtggc ctttgtggcc 4560 tggttctgcc tggttctgcc tcagagacga aatctcgcat ttatgttctg ataataaatg 4620 gcataaatga tgcatcgtta cattaatgca cgacataaaa cggggcggca agtaagacac 4680 acacacaaac aatacatatt aaaaatgtag atgggcctgt ttgtacagtg agctagaaaa 4740 gtaaaagtgc gctctttaaa atttaagcgg aagtggcttt cactttctac ttaacagtga 4800 aataaattag gcaaacaagc cagcttgaat tccaaggaga agccataagc caaggcagga 4860 atttaaatcc actcggagtg aaaatggtta tctcttaagt gatgcccaac ccgaaccaat 4920 tactttctgt ggaatttccg attttctcgg acggcacatt ccccaggcga ttttctaatt 4980 ggcacaggaa tttctaacca caagccatga aatattaaac ccgaagggaa attgaaaatt 5040 ctgccccaag gcttgggtgc tccacttctg gctgccactg tatgctcggc ttcgtatttt 5100 tctttccatt gtttctgctg tttgtttttc tcgtaaatta acgcaatgca tgtacataaa 5160 acaaaggctg gctgattatt actgcacggc acatgcctgc acgtcctttc cggagtttgc 5220 caaggtcctg ggtcctggtt cattagccgc tcgcttactt ataacacata cgccccgttg 5280 ccttcatttt ccagcttcgc acgctcacag caacgcagat gagttaagac agcaatatac 5340 gcgccgcaat tttaagttga aaagcatatt atttgcaaaa aagggaaaga acggcgaagg 5400 accgcctcta attacctcat aaataacgtc gcacgaaatt agctggccta aattatggcc 5460 ataactgcta attgcatatt tgatttcaat tagttcagct gacaggggcc caaaaaccca 5520 agaaggacac atttgaaatc agcgtgcgaa tgcaaatacg ttctgacagc tcgcttggac 5580 aaatctcatt tatggccagc caatttgacg aatgtccgcc cgccggggaa acaggcaaaa 5640 caaattcagc ttggccgaat catcgccggc ataaaaagga cattaccaga aatacataca 5700 tatacggagg cataagaaat ggttggtcct ggacgaagac caacggacaa atcgcacatc 5760 gtcctttctg ctcctctgce tctttgcagc atgctattat agaagattgt atgtaatctc 5820 gtacgattgc acacaatgga tttgccaaag gcgacacaaa aaaaaaaaaa aaaaaaaaaa 5880 taggggattg cgtgggggga gtttgcttgt gggtccttta ctttttttct cccccatgtg 5940 agaggttctg caatttcctg ctgctataat gcttataaat gttcacccgc aatcgccggg 6000 gatttcttta gggaattgaa aacataataa cagtgcgaat agtggcaagc attcgcattt 6060 tccacttatc caactaaata tgcagactaa aaattaaatt ccagtttttt caagccctcg 6120 aaggggattt ttattttacg cccttatatg tgtacctatg caaaaattcc gcaattccgc 6180 gggacaccgg ggaaaagtgc tattttcggt tctcattaat gtagctcatt aaattttata 6240 tgcataagct gccagctgca aacaaaaaat gtaagcattt aaaatttata agcgtgccac 6300 acaagagacc aacagcacat tacgtatacg cagcatggac aaagccagct tggaaagcca 6360 gcacgcaggc ataagcgtat agaaagtttg taattaaatt gctcatttaa gcgtggaaac 6420 aatgaattcg atcgggaata cagggagtgg ggagtgttct gaggaaatat gtaatattca 6480 gcgtgtaatc cgaagaaaat atattactaa ttttattcat ccgccttggg cgcttaaatt 6540 ttattgttcg gacttttgtg gactctcctc ggaggccgat aaggaaaagc cagtctagac 6600 aagccaacat cataatttgc aggcacgcac tgccatttcc atttccgccc aagcttgagc 6660 ctgatctgct ggccactttc catgcttaag tcagcacata tcctttagca ggaagatgga 6720 atgggatggg atggggctga cacttcagcg attgccaaca agtgttgcgt tttattgtct 6780 ggcctttaac agctctcctt tgccatccgc ccattgtgtg tgcggcacgt gcaggcgcct 6840 gcatttggag ctacgtgagg gatctccact cctgtggata gtccgagcat aaaaccataa 6900

137 aaatccgccg caaaaaaaga aacgaacctg gccaccaaat ctgttattta ttggcccaat 6960 aaaaatttgg tttaatgcat tacaagttgc cgaaatgcca cggagattgc cggagattta 7020 cttggcttgc aaagggaagt ccttaaggcc atggcaacaa gtccttcctg gttagcagtt 7080 agtttattag agtggtcaag tgcatggagt ggggggcatt tcggatttcg ggctgaaatt 7140 ttcccaatcg atactgcaaa cacgcaaaac aatgcctctg ctgccaacta atatccatac 7200 tctcggctca ttcagccaca gagttttcgt tttagtaacc gctggcattg ttttcagcag 7260 gtgagcgtgt gtatgcactg gcattttaat taaccacaat ttgtttctgc attccaaacg 7320 ccctgaaaac gcttaccttc tactcctagc caagtttcta tctgcagaat gagattcctt 7380 tcgccactca cactcacaat ttgcgttgga attcttggga ttacttgcgt ttagcactcg 7440 gactacggac cgcaaaagcg ccaggaggcg ggtcctttgt cctttcgacc acctacttga 7500 cccgtcctaa atgcgtttaa cgccttccaa gctgcgaaat gattatgtta aagcggtttt 7560 tgctggagcg gttatttttg ctagttgcct tggttattga cacacgccca tttacgtggg 7620 caaaacttta ttgagttcac atttatatgc gggattattt gttatagcga cccttgaact 7680 tattcgaagc actcaaagcc aacgactaga aaagttattc gacattaatg cgcggcactt 7740 atttgttatt tcttttgcgt ttgctaatta aaattttcat ttttctcttc gcacattatt 7800 taaaaattag tttccacttt aacggctctg aggaggacaa taggttttcg caagttttga 7860 aattccgaaa cgaaccgcac tcgtacacat cccgctgata actgcgggga tacccgaagg 7920 atgtgtctta acaaggctcg ccttcttacc aaaaggcgcc aattctgggt tccacaaagt 7980 gaaaagctcg caaagctgca ttccacaagc tgttgaaaaa gctttccgcc gggcaacagg 8040 tggaacatcc tgacgggagg ttgggtaaaa ggaccccaaa cagaaaccga ttcgattgca 8100 cttctaatgc ctgaaaatct gcctatttga tttatgcaaa tatgtgccgg agtctcatgt 8160 ttgcccagca attcgctggc tgtttgttta gggcatgcgg caaaagggat accccggact 8220 caacaggatt cggcaggatt cgccaggata ttgtttgtga aactccttgc aggccgtctt 8280 tgaagtcgca acctgattta attgtgattt tcggagcccg ttcaaaacac ctctcacgtg 8340 ggcctaatca aattaaactg aagtggcagc gcctcgggtc tgacagttat tgaaatatca 8400 atatggctag gctccgggaa aatggtttcc cggaaaatgt gcgaaattaa attgtagaga 8460 aaacaagggc aacattttta ctcactggca tcttttctca tgcctgccaa attttatatc 8520 acaatgataa acatttagac ggatgtcctg gctgcttgga atgcgtgcga cacatgaggg 8580 ttgcctgtgt ggatttttgg gcgcaaggat atgggcgggg tggtgggggc gatatctcca 8640 accaaactgt ttgattttta aacaaatgct aatgtcaact gccactcaga ggcatttaaa 8700 ttccaattta aaaatgcttt ctctcgatgc caaaagcaaa gacatgttcg ttgtcctgtt 8760 tcgagtccat ccactcgttc tttttctctc agattctccg attctctgac ccgtttctcc 8820 agttttctgc tcgcattaaa gcgttcgtcc tgtctcatgc atatttaatg tcacacg 8877

<210> 101 <211> 2089 <212> DNA <213> Drosophila

<400> 101 cggttcgttt cggaatttca aaacttgcga aaacctattg tcctcctcag agccgttaaa 60 gtggaaacta atttttaaat aatgtgcgaa gagaaaaatg aaaattttaa ttagcaaacg 120 caaaagaaat aacaaataag tgccgcgcat taatgtcgaa taacttttct agtcgttggc 180 tttgagtgct tcgaataagt tcaagggtcg ctataacaaa taatcccgca tataaatgtg 240 aactcaataa agttttgccc acgtaaatgg gcgtgtgtca ataaccaagg caactagcaa 300 aaataaccgc tccagcaaaa accgctttaa cataatcatt tcgcagcttg gaaggcgtta 360 aacgcattta ggacgggtca agtaggtggt cgaaaggaca aaggacccgc ctcctggcgc 420 ttttgcggtc cgtagtccga gtgctaaacg caagtaatcc caagaattcc aacgcaaatt 480 gtgagtgtga gtggcgaaag gaatctcatt ctgcagatag aaacttggct aggagtagaa 540 gtaccagaga tgccaagtgc caggatgttg tagaatgagt gaccacaacc acatcgattc 600 ggtgaacgcc agcgggagtg atccgctcct ggatctgcac aacctagatg gcatcggtga 660 gagcgtggag ttgcagtgcc tggtgcagga gcacatcgag gcatccacct atggcaacga 720 tagtggccac tgcctcaccc agttcgactc gatcctgtgc tggccgagga cagctcgcgg 780 taccctggcg gtgctccagt gcatggacga gttgcaggga attcattacg atagcagcaa 840 gaatgcaacg aggttctgcc acgccaatgg aacttgggag aagtacacca actacgatgc 900 ctgcgcccac ctgcccgccc cagaatccgt gccggagttc gaggtcatcg tggagctgcc 960 caccattatc tactacattg gatacaccct cagcctggta tcgctctcgc tggcgctgat 1020 tgttttcgcc tacttcaagg agctgcgttg cctgcgcaac accatccacg ccaacttgtt 1080

138 cttcacgtac atcatgtcgg ctttgttctg gatactcttg ttatccgtcc agatctccat 1140 ccgaagtgga gtgggcagct gcattgctct gatcaccctg ttccacttct tcaccctgac 1200 caacttcttt tggatgctgg tcgagggttt gtacctgtac atgctggtgg ttaagacttt 1260 ctccggggac aatttacgct ttaatatcta cgcctccata ggctggggtg gcccggcctt 1320 gtttgttgtc acctgggctg tggccaagag tctgacggtc acctacagca cccccgaaaa 1380 gtacgaaatc aactgcccct ggatgcagga gacccatgtg gattggatat accagggacc 1440 tgtctgtgcg gtgctaataa tcaatctcac atttctgctg cgtatcatgt gggttctaat 1500 cacaaagctg cgctcggcca atacagtgga gactcgtcag tataggaaag ctgctaaggc 1560 actgctggtg ctaatcccac tttttggcat cacctacctg gtggtgctgg ctggtccctc 1620 ggaatctggc ctaatgggac acatgtttgc cgtcctgcga gcggtattac tcagcactca 1680 gggattctcg gtgtcgctgt tctactgttt cctcaactcg gaggtgcgaa atgcactgag 1740 acaccacatt tccacgtggc gggacacgcg caccattcag cttaaccaga accgacgtta 1800 taccacgaaa agcttctcga aaggcggtgg ttccccccga gccgagagta tgcgaccttt 1860 gaccagctac tatgggcgtg gcaagcggga atcgtgcgta agttcggcca ccaccaccac 1920 gctggtgggt cagcatgccc cactttcact ccaccggggc tccaacaatg ccctgcacac 1980 gatgcccact ttggcggcaa atgccatgag ttccggcagc actctgagcg taatgccccg 2040 ggccattagt cccctgatga ggcaaggact cgaggagaac tcggtgtag 2089

<210> 102 <211> 504 <212> PRT <213> Drosophila

<400> 102

Met Ser Asp His Asn His He Asp Ser Val Asn Ala Ser Gly Ser Asp

1 5 10 15

Pro Leu Leu Asp Leu His Asn Leu Asp Gly He Gly Glu Ser Val Glu 20 25 30

Leu Gin Cys Leu Val Gin Glu His He Glu Ala Ser Thr Tyr Gly Asn 35 40 45

Asp Ser Gly His Cys Leu Thr Gin Phe Asp Ser He Leu Cys Trp Pro 50 55 60

Arg Thr Ala Arg Gly Thr Leu Ala Val Leu Gin Cys Met Asp Glu Leu

65 70 75 80

Gin Gly He His Tyr Asp Ser Ser Lys Asn Ala Thr Arg Phe Cys His 85 90 95

Ala Asn Gly Thr Trp Glu Lys Tyr Thr Asn Tyr Asp Ala Cys Ala His 100 105 110

Leu Pro Ala Pro Glu Ser Val Pro Glu Phe Glu Val He Val Glu Leu 115 120 125

Pro Thr He He Tyr Tyr He Gly Tyr Thr Leu Ser Leu Val Ser Leu 130 135 140

Ser Leu Ala Leu He Val Phe Ala Tyr Phe Lys Glu Leu Arg Cys Leu

145 150 155 160

Arg Asn Thr He His Ala Asn Leu Phe Phe Thr Tyr He Met Ser Ala 165 170 175

Leu Phe Trp He Leu Leu Leu Ser Val Gin He Ser He Arg Ser Gly

180 185 190

Val Gly Ser Cys He Ala Leu He Thr Leu Phe His Phe Phe Thr Leu 195 200 205

Thr Asn Phe Phe Trp Met Leu Val Glu Gly Leu Tyr Leu Tyr Met Leu 210 215 220

Val Val Lys Thr Phe Ser Gly Asp Asn Leu Arg Phe Asn He Tyr Ala

225 230 235 240

Ser He Gly Trp Gly Gly Pro Ala Leu Phe Val Val Thr Trp Ala Val 245 250 255

Ala Lys Ser Leu Thr Val Thr Tyr Ser Thr Pro Glu Lys Tyr Glu He 260 265 270

Asn Cys Pro Trp Met Gin Glu Thr His Val Asp Trp He Tyr Gin Gly 275 280 285

139 Pro Val Cys Ala Val Leu He He Asn Leu Thr Phe Leu Leu Arg He

290 295 300

Met Trp Val Leu He Thr Lys Leu Arg Ser Ala Asn Thr Val Glu Thr 305 310 315 320

Arg Gin Tyr Arg Lys Ala Ala Lys Ala Leu Leu Val Leu He Pro Leu

325 330 335

Phe Gly He Thr Tyr Leu Val Val Leu Ala Gly Pro Ser Glu Ser Gly

340 345 350

Leu Met Gly His Met Phe Ala Val Leu Arg Ala Val Leu Leu Ser Thr

355 360 365

Gin Gly Phe Ser Val Ser Leu Phe Tyr Cys Phe Leu Asn Ser Glu Val

370 375 380

Arg Asn Ala Leu Arg His His He Ser Thr Trp Arg Asp Thr Arg Thr 385 390 395 400

He Gin Leu Asn Gin Asn Arg Arg Tyr Thr Thr Lys Ser Phe Ser Lys

405 410 415

Gly Gly Gly Ser Pro Arg Ala Glu Ser Met Arg Pro Leu Thr Ser Tyr

420 425 430

Tyr Gly Arg Gly Lys Arg Glu Ser Cys Val Ser Ser Ala Thr Thr Thr

435 440 445

Thr Leu Val Gly Gin His Ala Pro Leu Ser Leu His Arg Gly Ser Asn

450 455 460

Asn Ala Leu His Thr Met Pro Thr Leu Ala Ala Asn Ala Met Ser Ser 465 470 475 480

Gly Ser Thr Leu Ser Val Met Pro Arg Ala He Ser Pro Leu Met Arg

485 490 495

Gin Gly Leu Glu Glu Asn Ser Val 500

<210> 103 <211> 3731 <212> DNA <213> Drosophila

<400> 103 catcgattaa ccactatccc atttattgcc tgcccgtcta cacaaatcgg cacgtgaacg 60 aggactggta tcgactttat aggacctacg acaccgaggg atttgttttc gggcagtttt 120 acgagcgtct ccagcggtac gagttggact gaattaatgc cctttttcag aaagaataag 180 atttagacaa aatctgtgat atcgatactg tggtagcgtt gcagagatcc caatcgcgtg 240 tgtggcgaag gacgcagaca gataacacat tcctccgtgc tgaaaatcaa ttataattag 300 tcgtgggaaa caactaaaag aatataaaaa tggcccgttg gtttataaaa aatataatac 360 tttaatctga tctcttataa tgtaaactat catgcaatac ttagggacga acggatgtgg 420 tctacatgta tgtcgtatac gtatattttt gtgtggtgtt cattcatagt gtccagtggg 480 tataggactt gttgatgtca gtctacaata aacgataaac agaaaaagga aaaccccaat 540 cagaaacata agaaaataag taagaataaa aaggatatct aaagccaacc aaccatgcag 600 aataaacata acattaagaa ctgatgtagg gaaatgcacg gttttaagta gatcacttta 660 gttggcacga gtgtgttagt atatttagag aacgggtgca atttaacttt ggaattattt 720 ggatgggtgg atgtcaaaga agtagaaagc atatacatga gcattgcgta tacgcaccgt 780 agactttcgg ttcgcgatct cagcgagtag tcttttgagg cgcgatgcct gaaatggaaa 840 ttaattggtt aaatgacaac aacaacaaca acaacatcga cgacaatagc gaacaactac 900 aatatcagcc atagccacat caactaggta gtgcaaatag tgaaaagcca atatgtcgac 960 agccagggtt atataaatat aatccaacaa caataatgtg ctagaatgcc aaatgagtgc 1020 agtcgcccct caatgattgg ttagcccacc tgcgattctt gatggaactg ttccgatgga 1080 tattcctgct ctcccgccac cgggtgaatc catgcctcag cgtctggcgc acctctgagt 1140 taaggaaaca gtagaacaga gccacaaaga agccctaaag aatggatttt cgaagatcaa 1200 tgtttatgga aagactgtca cctaatctat atacctgcgt gcttatgaga aaggctctta 1260 tggcctcgaa gagattacga ctgataccct gttccgggcc tgttagcacc aacagatagg 1320 tgatgccaaa gagaggtatc agcaccagca gcgccttcga ggccttgtaa tactgccgcg 1380 tttccagggt atgagcagaa cgtaatttag tgatgagtac ctgtacgata tgatataata 1440

140 gcatgaagct aactcactta agccagaagt taaccggggg actcacccac atgatgcgta 1500 tgaggaatac tagattaacc agcaaagcca gtgatgcagg taccttgaat atccagtcaa 1560 tgtgagattc acgcatccat gcacaatcaa tttccagctt ttgaaaaatc agaagaggtt 1620 agcaagcata tctaggtagg tggcaattgg tatcataccc cattgaagtg ctcgttctcg 1680 agatgcggag caaatgcctt ggcaatggac cacaccaaaa tgcatacggc tggacagccc 1740 cagccgatga gggcgtagat aataaagcta atgttatcac tggagaatgt ttgcaccacc 1800 agcgtgtaca gatagaggcc tataaaaagc aaatgataaa accgaggaaa ttcaattgat 1860 accgcctttg aacccaccct ccacaaacat ccagaaaaag ttggttaggt aaaagtactg 1920 aaacatgatt accaacgtta tgcagccagc ctgactagac tctgtggtta tctaagtgaa 1980 taattaatta gtggagtggg atatatatat tccagcttat cttaccactt gcaggaacag 2040 tgtgagtatc cagaggagtg cggatgtgat gtaggtgagg aacaaattgg catgaatggt 2100 gtttcgcagg caacgaagat ctctgaagag ttttaagcat gaaaatgatg caactcatgt 2160 gtggcattac aactcactta aagctgagga atatgatgag agccaccacc aaggtggcga 2220 agctcaggaa ataaccgccg gcatatatga tggccggcag ttcgacgttg ggtgagaagt 2280 cgggcaccac cggtatggag cccgagttct ggtgacagcg gtcatagtcc gaatagtgat 2340 cccacgttcc gtttggaaag caaaagcggg tggcattgtc tgcaaatata ttgattttat 2400 ttaagatcta aacccaatct ggaataccca cctgtggtgt cgtagtgcac gcccttgaat 2460 tcctcgaaac agggtagtac agccagactg ccggcgtttg tgcgtggcca gcacaggacc 2520 gaatcgaacg agctgggaca ttgtaaaatc tgtaagaaat aacaattgag aatatacaat 2580 gattggcaag gtaaacttcg ttgagcattt actgcagtat aattcgtgtt tcccctctgt 2640 aaacgcaact gacctagccc aaaacccatt aaatcagagt acataagatt catgccccgt 2700 ttctgactcg gtataataat gatgccttca ttgcggatcc tggtcattta tagctctgac 2760 gcatgatttt ctttaatcaa atttagtttc cagactttac acacacacat acgcagcgtg 2820 agccaaatat cgatgtagtc ccaaaaaaaa aataaagaaa gaatcaccag ctaccgcttt 2880 atttatatat ttgcaatggc gtgctaaaca atttcgtgca tacggataca caagttatat 2940 gtacatatat gtatattaac gttaagtata cgacgacccg gcgattgttt acccagttca 3000 gttcgtagcg ccaaattaat cgcgacgcgc tatggtagcg gtgttagaaa cagagcttca 3060 ttgatatttt ttttattgac cttatcaggt gacgccgaga gcgcggagcg gagactcgtc 3120 gaagaattca ccaaattggc aattctttta tggccggtct tcccattact gataagcccg 3180 agaacctttt tgcgacagct aatgcgatcg gacttagcca cgcgacaagt gagctgtcaa 3240 cgagtaagcc aaacactgga gactggaaac tccggcaata tttgtttctt tgctcttctg 3300 attttcactc attagcctcg tcatttggac acagtcatag tacgaataca ttttatgaca 3360 ttttcgagga acaacgccct tgatcgtgca ttcggtataa acaaaaatgg ctaaatgcag 3420 cctcaagtgg atttccttgg gtctagtttt gtttacaggc gagaggaata cataaataaa 3480 tatgtgctgc attttccgga aataaaatgc caaaataatt taatccgaaa gcgatcgaca 3540 gtttacttgc ctggtttttc atcgtatcgt acttaaagtg aaagagattg acgggcggat 3600 ggattgaagc caattatttc ggaacagaag atggatcaat tagcgggtgc gattaattgg 3660 gaaattcctc aatcggcaaa agagatgaat tcattggcca aacaaagggt aattagggaa 3720 tatttattgg c 3731

<210> 104 <211> 1167 <212> DNA ' <213> Drosophila

<400> 104 atgaaggcat cattattata ccgaatttta caatgtccca gctcgttcga ttcggtcctg 60 tgctggccac gcacaaacgc cggcagtctg gctgtactac cctgtttcga ggaattcaag 120 ggcgtgcact acgacaccac agacaatgcc acccgctttt gctttccaaa cggaacgtgg 180 gatcactatt cggactatga ccgctgtcac cagaactcgg gctccatacc ggtggtgccc 240 gacttctcac ccaacgtcga actgccggcc atcatatatg ccggcggtta tttcctgagc 300 ttcgccacct tggtggtggc tctcatcata ttcctcagct ttaaagatct tcgttgcctg 360 cgaaacacca ttcatgccaa tttgttcctc acctacatca catccgcact cctctggata 420 ctcacactgt tcctgcaagt gataaccaca gagtctagtc aggctggctg cataacgttg 480 gtaatcatgt ttcagtactt ttacctaacc aactttttct ggatgtttgt ggagggcctc 540 tatctgtaca cgctggtggt gcaaacattc tccagtgata acattagctt tattatctac 600 gccctcatcg gctggggctg tccagccgta tgcattttgg tgtggtccat tgccaaggca 660 tttgctccgc atctcgagaa cgagcacttc aatgggctgg aaattgattg tgcatggatg 720 cgtgaatctc acattgactg gatattcaag gtacctgcat cactggcttt gctggttaat 780 ctagtattcc tcatacgcat catgtgggta ctcatcacta aattacgttc tgctcatacc 840

141 ctggaaacgc ggcagtatta caaggcctcg aaggcgctgc tggtgctgat acctctcttt 900 ggcatcacct atctgttggt gctaacaggc ccggaacagg gtatcagtcg taatctcttc 960 gaggccataa gagcctttct cataagcacg cagggcttct ttgtggctct gttctactgt 1020 ttccttaact cagaggtgcg ccagacgctg aggcatggat tcacccggtg gcgggagagc 1080 aggaatatcc atcggaacag ttccatcaag aatcgcaggt gggctaacca atcattgagg 1140 ggcgactgca ctcatttggc attctag 1167

<210> 105 <211> 388 <212> PRT <213> Drosophila

<400> 105

Met Lys Ala Ser Leu Leu Tyr Arg He Leu Gin Cys Pro Ser Ser Phe

1 5 10 15

Asp Ser Val Leu Cys Trp Pro Arg Thr Asn Ala Gly Ser Leu Ala Val

20 25 30

Leu Pro Cys Phe Glu Glu Phe Lys Gly Val His Tyr Asp Thr Thr Asp

35 40 45

Asn Ala Thr Arg Phe Cys Phe Pro Asn Gly Thr Trp Asp His Tyr Ser

50 55 60

Asp Tyr Asp Arg Cys His Gin Asn Ser Gly Ser He Pro Val Val Pro 65 70 75 80

Asp Phe Ser Pro Asn Val Glu Leu Pro Ala He He Tyr Ala Gly Gly

85 90 95

Tyr Phe Leu Ser Phe Ala Thr Leu Val Val Ala Leu He He Phe Leu

100 105 110

Ser Phe Lys Asp Leu Arg Cys Leu Arg Asn Thr He His Ala Asn Leu

115 120 125

Phe Leu Thr Tyr He Thr Ser Ala Leu Leu Trp He Leu Thr Leu Phe

130 135 140

Leu Gin Val He Thr Thr Glu Ser Ser Gin Ala Gly Cys He Thr Leu 145 150 155 160

Val He Met Phe Gin Tyr Phe Tyr Leu Thr Asn Phe Phe Trp Met Phe

165 170 175

Val Glu Gly Leu Tyr Leu Tyr Thr Leu Val Val Gin Thr Phe Ser Ser

180 185 190

Asp Asn He Ser Phe He He Tyr Ala Leu He Gly Trp Gly Cys Pro

195 200 205

Ala Val Cys He Leu Val Trp Ser He Ala Lys Ala Phe Ala Pro His

210 215 220

Leu Glu Asn Glu His Phe Asn Gly Leu Glu He Asp Cys Ala Trp Met 225 230 235 240

Arg Glu Ser His He Asp Trp He Phe Lys Val Pro Ala Ser Leu Ala

245 250 255

Leu Leu Val Asn Leu Val Phe Leu He Arg He Met Trp Val Leu He

260 265 270

Thr Lys Leu Arg Ser Ala His Thr Leu Glu Thr Arg Gin Tyr Tyr Lys

275 280 285

Ala Ser Lys Ala Leu Leu Val Leu He Pro Leu Phe Gly He Thr Tyr

290 295 300

Leu Leu Val Leu Thr Gly Pro Glu Gin Gly He Ser Arg Asn Leu Phe 305 310 315 320

Glu Ala He Arg Ala Phe Leu He Ser Thr Gin Gly Phe Phe Val Ala

325 330 335

Leu Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Gin Thr Leu Arg His

340 345 350

Gly Phe Thr Arg Trp Arg Glu Ser Arg Asn He His Arg Asn Ser Ser

355 360 365

He Lys Asn Arg Arg Trp Ala Asn Gin Ser Leu Arg Gly Asp Cys Thr

142 370 375 380

His Leu Ala Phe

385

<210> 106

<211> 7564

<212> DNA

<213> Drosophila

<400> 106 tttccgctgc catctgcagc tgtagctgcc taacaaatgc aattaaaatc tttgcgcaag 60 aaaattgttg cagcaggcac gcagagatac tcgtactgta tgtgctgcaa tagtttggtg 120 gcagcaacgg ggcggcagat aacatattgc ccacgtccgg ctgaaattgt acggacaagg 180 cgaactcaaa aaaaaaaaaa aaaaaaagga atccctcaaa aggagaacca agaaaaatgg 240 gatttatctc tggccaagct ccagccatac aaatctaatt tagaccacac gacggcttca 300 gatattttat attccccact cagttgcggt ccatcctgat ctcctccagc ttgcttgatg 360 agcccagccg ttggccaaat gaaattattt atgggcagtc ctaggtcagt gagaatttgg 420 ttttttaagg gtttgaactt tgcggctcaa caatgcctgt gatttttttt ttttttatta 480 tttttttgca ttgcatccat tagagaaagc actcctttgg cattctactc agctacttgc 540 cacataaata tctacggagg gtagctaact agtccttatc tcaacttccc catttatcct 600 cgccgcaagt gcacttttcc tgctgctaat taagttgcaa ggcagctttc tcagcaggcg 660 ttgcacgaag tagataaaag gaaaagcccc cgatttgcag acactatgct gggaaagata 720 tatatatata tatattttgc cagcattcgc taatcggctt agggcagcca ccatgcgacc 780 acaacaacaa caacaacagc agcagcagtg tgctccatgc aatatttaat cacattagtt 840 gatggggtaa cggccatgta cgcaacaatt tacaacttgc attaattata cgtctagttg 900 gacaatggcg cctctaacta tcccactcta aatgtatctc tatctctatc cttatttgca 960 ggggacaccc gttgataata aattattaat gcatctgctg ggaaggcggc actgcacggc 1020 tgtccttggc agcaaatcca gttgcaacat cggtgagtga cgggcggcaa tcacaaagga 1080 cttgcaacag ttgccgttgc ttctgctatt gctgttgctg ttgctgttgc aacaatggcc 1140 agtggcaaca atgaaactga gccgctctac tgcggcagcg gcatggataa ttttcataca 1200 aggtaagcga ctttcaccaa tgtcacgatc aaggccaagg ggcttttcca ccagacatgg 1260 cgacaacaat accataagcc aacagttggg ggcgtggtcg ggggcggagg cgatggtggc 1320 aacatcatag ccattagctg ctggcgcaag ggaaccgttc aaaaatcgat tatcgcccca 1380 tttcggggga gcttctattt tgatttgccg tacaattttc tcgggcgatt aaacgacgaa 1440 gcagaacgaa aacaaaaaac agatttgtca acagcaaggt caacaattga tggctgaaat 1500 caatttaatt gaccatatcc tacgggccct ccaagtggcc atctgctgca cctataaaaa 1560 agtgaatccg gtctgcgatt atttatatat tcgttgcatg gcaggcggtc gtaaaacctc 1620 gagatgatga ttaaaagcgg ccctaaaaac ttaatggcgg tttaggaaat tcaattcctg 1680 taatttaagc cgagtcacca ttcttcgaag ttcttacatg taagcgataa taaatagtta 1740 agtcaattgg ccaataaacc tattaatatt gtgcatttac cacgattaga ctttgattaa 1800 agtgacaatg ctgatttctg tagaggaaat ctagttctag tcttcccaca aagctattta 1860 gttactcttg aataaatatg ttacttttct tttgccaaaa ccaacagaat tttaaattta 1920 ataatttgga ttttttgcaa taaactgtac tgattaatgg gccacacaaa aatgtctagt 1980 ttattatgga gctcttggtt tcataaatta agaacataat ccaatcggca tataaatcat 2040 tgatagcaat ttattttccg tgatgaaact gtgctccgtg tgaactgcga attactcatt 2100 ctacggttgc aaaaaaagcc accaacggtc aacatttaga ccaggacttt tagttttaat 2160 tagagccagc ctggccaaca gcagtgttaa tgaccacaaa gtggctggcc acaggatcag 2220 catcccagaa tgcgatgccg catttgcttt aattaaaggt agtagctgga gtttgaaaga 2280 tgactgtatg gcaattagat gtgtagccag aacacttggc catttacttt tgtgtcaaag 2340 tcgtgccaaa ttgccagcgg aggcgacact tgacgctgtc acgccccaga cagacgcaga 2400 ccggcccaaa agcacccact cagccgtctc caggcgccac tcaagcggca aaggaacgcc 2460 aaaacactag gacacagaac gccagaagac tcgaaaaaaa agtataaaat tcaaacgcgt 2520 atacaattca atgtgtcaca tcgaagaaga accctttctc tggcggcaac gtgacgtata 2580 cgcaatatta atggcaaagc gaaaagggcc tcaaaagcta acgaaaaacc gcagcataac 2640 acgcacaaaa caagcaatta acataaataa taaagaacgc acaaaggcgt tcggctctcc 2700 gttgccaaag agaaaagcca acgaaaggaa taaaaaacgc caaaaagccc gaaaaaaaaa 2760 ccgaagaccc aaaaaatgtg taaaattgat ttcggaaaat atttaattta ccaaatgcat 2820 gctcgctttt tgcggccgtg tacgccccga acaaataaaa caaataggca cacatcgtct 2880 ggcatttcat gttaaaggct tctcatgctg atggacagga tacagaaaat atatatacga 2940

143 agtgaggtgt gtgtctacgt gccacaaaaa cagcgaaatt gaaacgcttt ccgaatgccg 3000 gcgacacttt ttggcggcac aaccctcgtc ttgtcgacca actcctgggg aatttacaac 3060 tccattcatc aaactcacaa aaactttgcc tggtgtacgg tcttgggttc gtcgtcgcag 3120 gatttcacct ggctaaaaat ccagactccc agccatccct gagtctaatt tatggccttt 3180 gataatccat gttgatgaat ggcggcaacg acaacaacgt cgacgacatg aatgaagtcc 3240 tggaattgtt ttgcaccagg atggcatcgg ggctccaggt gggacgtact ggctcaaagt 3300 tattggccca gaaatcaggc atagttagct gccgaaatga aacccaaata ccgagaaaac 3360 taggcaaaac aaacagtagt acaccggaaa tgcatatcat tgtaaaaact acatcagttt 3420 acctaaaagg cttggctttt aagctttcac atttataaaa tattgaaaat gcatataaaa 3480 gtatgaaatt aattcccttt tgtcaataaa ctttctttct ttctttctgt gtaatatggg 3540 ggataccggt tttttttttt tttcaatgaa atcccttcga aaggtataag ttcagaatcg 3600 agagttttat gccaagttgg gcacagtttt ttttttcccc agctacctaa aataatagag 3660 acattttcct cccactacaa ctgattgcat tgccggtgca gaaagttttt tcagttggtt 3720 cggaaaaatt tggttcgcaa acaaattaat atgaactggc aagcattttt cgggcaaaaa 3780 gctctcatct atgtagattg gaatggaaat tccggctaga attgcataag accacctgca 3840 gtgtgggcta acatgactaa aaagttgtcc acaaatttgg cttagattct ccaataaaac 3900 tgtcgttcgg ccaggaatcc ccttttttgt ttcgagtgaa tggggaattt cgcacgacag 3960 acagcaataa agaatttaac taaagtcctg acaccgacag caccagcagg acgcacacgt 4020 gtcactccat ttggagagct tggagtatat taaacatttt ttccccacca gtcagccgca 4080 ggacttgcat cggtctcgcc tcgcattttc ctatataaat tttatgctaa gtctaatttg 4140 ttggctgcaa cttgcacaaa ggcaaaaaat aaacaagggc gaaatgccga aagccaaaac 4200 ccaaccgaaa ccgttgaggg ctgcctcgct tttttcctgt gccgaattcc ctaaaacttt 4260 gcacataaat ttgagtcctg cgcctgggct tttcctcttc cacctttttt tttagcctca 4320 aagcgctcga cgaaaactaa acaaaagctg gtaaaatgtt tatcccagaa gggggcggtg 4380 tgggcgtggc ttgcttaagc cctagacacc cgagagttta ttgcctcagt gttgcaaacg 4440 ctgctgcttg gcaagtcaac ggaaatggct ttcggatggt tttattgcct acttttgctg 4500 cgagaaagcg gactagacat ggaagtaaca aattggttaa ggctaactag agcataataa 4560 cagaaacatc agaaacataa tttgggaaat gcctgccact caccgacaac atttcgattt 4620 gtgtctttat tacacttctc tgccgtgatg ggttataact tttggatcct tgcagagagt 4680 tgggaaattg cttaaaaata aaatttgttt aatttaattt gaggtggttt ttcaaacaat 4740 tttaatggat taataagttt aggaagttaa gtatatacat ctatctatta taccatcttc 4800 aaatattgtt gaattgaaga gataactcgg agctaatccc atatttttca tttttttcag 4860 ctacaagaac atgcatggct atgtttcgct ggtggtctgc atcctgggca ccatcgcgaa 4920 taccttgaat atcattgtgc taacccgacg ggagatgcgc tcccccacga atgccatact 4980 cacgggtctg gccgtggccg acctggcagt tatgctggag tatataccct acaccataca 5040 cgactacatc ctgacggaca gtttgccgcg ggaggagaag ctcagctaca gctgggcctg 5100 cttcatcaag ttccattcga ttttcgccca ggttctgcac accatttcca tttggctgac 5160 ggtgaccctg gctgtttggc gttatatagc ggtgggttat ccgcaaaaga atcgcgtatg 5220 gtgcggtatg agaaccacca taataacgat aaccaccgct tatgtggtgt gtgttctggt 5280 ggtgtcgccg tcgctctatt tgatcacggc tataaccgaa tatgtcgatc agttggatat 5340 gaatggcaaa gtgataaact ccattcccat gacccagtac gtaatcgatt atcgtaatga 5400 gttactgagt gccaggacgg ctgccctgaa tgccacgccc accagtgcac cactgaacga 5460 aactgtgtgg ttaaatgcga gcaccttgct gacatcgaca accaccgctg caccacccac 5520 gccatcgcca gtggtgcgaa atgttactgt ctataggcta taccacagcg atttggcgtt 5580 gcacaatgcc tcgctgcaaa atgccacatt tctcatatac agtgtagtga ttaagctgat 5640 accatgcata gcactcacca ttctgtcggt tcgattgatc ctggccttac tggaggccaa 5700 gcggcggcgg aagaagctca ccagcaagcc cgccactccg ggtgccagta atggaaccaa 5760 atcaccggcc aatggtaaag cagcggatag gccccggaaa aatagcaaaa ctctggaaaa 5820 ggaaaagcag acggatcgca ccacgagaat gctgctggcg gtgctactcc tctttctcat 5880 cactgaattt ccacaaggga ttatgggtct gctgaatgct gtgctcggag atgtcttcta 5940 tctgcagtgc tacctaagac tgagtaagta aatatgtact atgcataacg ccacagtaaa 6000 ttccacagat tcccatttca ctttaagatg taataaccca atgccttttg ccttttgcca 6060 ccaggtgacc tgatggatat cttggccctg atcaactcca gcatcaactt cattttgtac 6120 tgctccatga gcaagcaatt ccgcaccacg ttcacgctgc tctttcgtcc aaaattcctg 6180 gacaagtggc tgccggtggc gcaggacgaa atggcagctg ctcgagctga acgctctgcg 6240 gtggcaccgg tcctggaaaa gggacgacag cagccgcagg tggtgatggc cagcacgacc 6300 accaacatca cgcaggtgac aaatctgtag cacaggagga gtcgtggtcg ccgaactttg 6360 ctcagtcgcc tgctgagtgt cctgaaacgc ggcagaaggc gctcctccgg cgaaggagga 6420 ggcgtgggag gaggtggtgc gccgttggcc ggcaacgatg cggtggaacc agcgttccag 6480 gccatcgtgg tggtggtgga caaggtgagc ggtgccacgg agaatcagct gtacaccgcc 6540

144 gagcaagctc gtattgtgac gtagtaaccc tgatagtagt acatattata tgcctagtta 6600 tccttgtaaa aagtaaacta gttgtgtaag aatcgcagat aaccacaagt tatgtgcata 6660 ctttggtggg aaatcgtaaa acccgtacag tcataataat aaaatgctgg ttcatcactc 6720 atacgcaccg tttgacttca ctctattcca cattcacagt caagtaggag ctgtaaaaat 6780 gctgtgcata aacgagctcg tatacgctac agctggcgtc acaataatag ttaccattgg 6840 gttggcttca caacatagat caaagtcaaa aaatatatag ttttgtaaaa tgtttcataa 6900 atctatcttc atatttaact aacacaattc agaaactttc gcttgcatgg aaaatgtttt 6960 attttcccca cttgacccaa ttgtgcgcaa ctgttcagct tttcggcatg aatcaaatca 7020 aatatagtaa acttttgcat cttttccact ttgatcccat gcgttttcat gttgatttca 7080 ttcgcataaa gtatgcagca cacgtactca ctcaaaacta cgaattttcg gcaacgattt 7140 gagcagaata tttgccattt gttgtacaga ttatatatac acacacacac acttatgtcc 7200 gtatctttaa taatggcaat taagtcctag aaattttgac ctgatattga tgcaggcatt 7260 ggaaaaataa gtggcagttg cagtgcggtg cgttgataaa tgaaatactt tgcgaattct 7320 attattggaa atcgcaattt gggctgtgaa tgaaattata gttttcttga acgcaattga 7380 gaattcagtt ccgtttcgtg ggttactgaa tttatgggaa ataatttaag gcagtcactg 7440 cagctgaccg aataatccaa tgaaacattg cataaacagt ttgcagtttt tccacacttg 7500 cgaaaattgt aattgcaaat cgcttaagcc ccacgacgaa tgacaaatgg ccagcgaacg 7560 cata 7564

<210> 107 <211> 1757 <212> DNA <213> Drosophila

<400> 107 ggaaggcggc actgcacggc tgtccttggc agcaaatcca gttgcaacat cggtgagtga 60 cgggcggcaa tcacaaagga cttgcaacag ttgccgttgc ttctgctatt gctgttgctg 120 ttgctgttgc aacaatggcc agtggcaaca atgaaactga gccgctctac tgcggcagcg 180 gcatggataa ttttcataca agctacaaga acatgcatgg ctatgtttcg ctggtggtct 240 gcatcctggg caccatcgcg aataccttga atatcattgt gctaacccga cgggagatgc 300 gctcccccac gaatgccata ctcacgggtc tggccgtggc cgacctggca gttatgctgg 360 agtatatacc ctacaccata cacgactaca tcctgacgga cagtttgccg cgggaggaga 420 agctcagcta cagctgggcc tgcttcatca agttccattc gattttcgcc caggttctgc 480 acaccatttc catttggctg acggtgaccc tggctgtttg gcgttatata gcggtgggtt 540 atccgcaaaa gaatcgcgta tggtgcggta tgagaaccac cataataacg ataaccaccg 600 cttatgtggt gtgtgttctg gtggtgtcgc cgtcgctcta tttgatcacg gctataaccg 660 aatatgtcga tcagttggat atgaatggca aagtgataaa ctccattccc atgacccagt 720 acgtaatcga ttatcgtaat gagttactga gtgccaggac ggctgccctg aatgccacgc 780 ccaccagtgc accactgaac gaaactgtgt ggttaaatgc gagcaccttg ctgacatcga 840 caaccaccgc tgcaccaccc acgccatcgc cagtggtgcg aaatgttact gtctataggc 900 tataccacag cgatttggcg ttgcacaatg cctcgctgca aaatgccaca tttctcatat 960 acagtgtagt gattaagctg ataccatgca tagcactcac cattctgtcg gttcgattga 1020 tcctggcctt actggaggcc aagcggcggc ggaagaagct caccagcaag cccgccactc 1080 cgggtgccag taatggaacc aaatcaccgg ccaatggtaa agcagcggat aggccccgga 1140 aaaatagcaa aactctggaa aaggaaaagc agacggatcg caccacgaga atgctgctgg 1200 cggtgctact cctctttctc atcactgaat ttccacaagg gattatgggt ctgctgaatg 1260 ctgtgctcgg agatgtcttc tatctgcagt gctacctaag actgagtgac ctgatggata 1320 tcttggccct gatcaactcc agcatcaact tcattttgta ctgctccatg agcaagcaat 1380 tccgcaccac gttcacgctg ctctttcgtc caaaattcct ggacaagtgg ctgccggtgg 1440 cgcaggacga aatggcagct gctcgagctg aacgctctgc ggtggcaccg gtcctggaaa 1500 agggacgaca gcagccgcag gtgcacagga ggagtcgtgg tcgccgaact ttgctcagtc 1560 gcctgctgag tgtcctgaaa cgcggcagaa ggcgctcctc cggcgaagga ggaggcgtgg 1620 gaggaggtgg tgcgccgttg gccggcaacg atgcggtgga accagcgttc caggccatcg 1680 tggtggtggt ggacaaggtg agcggtgcca cggagaatca gctgtacacc gccgagcaag 1740 ctcgtattgt gacgtag 1757

<210> 108 <211> 540

145 <212> PRT

<213> Drosophila

<400> 108

Met Ala Ser Gly Asn Asn Glu Thr Glu Pro Leu Tyr Cys Gly Ser Gly

1 5 10 15

Met Asp Asn Phe His Thr Ser Tyr Lys Asn Met His Gly Tyr Val Ser

20 25 30

Leu Val Val Cys He Leu Gly Thr He Ala Asn Thr Leu Asn He He

35 40 45

Val Leu Thr Arg Arg Glu Met Arg Ser Pro Thr Asn Ala He Leu Thr

50 55 60

Gly Leu Ala Val Ala Asp Leu Ala Val Met Leu Glu Tyr He Pro Tyr 65 70 75 80

Thr He His Asp Tyr He Leu Thr Asp Ser Leu Pro Arg Glu Glu Lys

85 90 95

Leu Ser Tyr Ser Trp Ala Cys Phe He Lys Phe His Ser He Phe Ala

100 105 110

Gin Val Leu His Thr He Ser He Trp Leu Thr Val Thr Leu Ala Val

115 120 125

Trp Arg Tyr He Ala Val Gly Tyr Pro Gin Lys Asn Arg Val Trp Cys

130 135 140

Gly Met Arg Thr Thr He He Thr He Thr Thr Ala Tyr Val Val Cys 145 150 155 160

Val Leu Val Val Ser Pro Ser Leu Tyr Leu He Thr Ala He Thr Glu

165 170 175

Tyr Val Asp Gin Leu Asp Met Asn Gly Lys Val He Asn Ser He Pro

180 185 190

Met Thr Gin Tyr Val He Asp Tyr Arg Asn Glu Leu Leu Ser Ala Arg

195 200 205

Thr Ala Ala Leu Asn Ala Thr Pro Thr Ser Ala Pro Leu Asn Glu Thr

210 215 220

Val Trp Leu Asn Ala Ser Thr Leu Leu Thr Ser Thr Thr Thr Ala Ala 225 230 235 240

Pro Pro Thr Pro Ser Pro Val Val Arg Asn Val Thr Val Tyr Arg Leu

245 250 255

Tyr His Ser Asp Leu Ala Leu His Asn Ala Ser Leu Gin Asn Ala Thr

260 265 270

Phe Leu He Tyr Ser Val Val He Lys Leu He Pro Cys He Ala Leu

275 280 285

Thr He Leu Ser Val Arg Leu He Leu Ala Leu Leu Glu Ala Lys Arg

290 295 300

Arg Arg Lys Lys Leu Thr Ser Lys Pro Ala Thr Pro Gly Ala Ser Asn 305 310 315 320

Gly Thr Lys Ser Pro Ala Asn Gly Lys Ala Ala Asp Arg Pro Arg Lys

325 330 335

Asn Ser Lys Thr Leu Glu Lys Glu Lys Gin Thr Asp Arg Thr Thr Arg

340 345 350

Met Leu Leu Ala Val Leu Leu Leu Phe Leu He Thr Glu Phe Pro Gin

355 360 365

Gly He Met Gly Leu Leu Asn Ala Val Leu Gly Asp Val Phe Tyr Leu

370 375 380

Gin Cys Tyr Leu Arg Leu Ser Asp Leu Met Asp He Leu Ala Leu He 385 390 395 400

Asn Ser Ser He Asn Phe He Leu Tyr Cys Ser Met Ser Lys Gin Phe

405 410 415

Arg Thr Thr Phe Thr Leu Leu Phe Arg Pro Lys Phe Leu Asp Lys Trp

420 425 430

Leu Pro Val Ala Gin Asp Glu Met Ala Ala Ala Arg Ala Glu Arg Ser 435 440 445

146 Ala Val Ala Pro Val Leu Glu Lys Gly Arg Gin Gin Pro Gin Val His

450 455 460

Arg Arg Ser Arg Gly Arg Arg Thr Leu Leu Ser Arg Leu Leu Ser Val 465 470 475 480

Leu Lys Arg Gly Arg Arg Arg Ser Ser Gly Glu Gly Gly Gly Val Gly

485 490 495

Gly Gly Gly Ala Pro Leu Ala Gly Asn Asp Ala Val Glu Pro Ala Phe

500 505 510

Gin Ala He Val Val Val Val Asp Lys Val Ser Gly Ala Thr Glu Asn

515 520 525

Gin Leu Tyr Thr Ala Glu Gin Ala Arg He Val Thr 530 535 540

<210> 109 <211> 5251 <212> DNA <213> Drosophila

<400> 109 taaccttctt ttgaccttcg taagtcttcc actggcactt gaaaagcttt gggaaaacag 60 ctgtgaattt gcccagcaga gcttccgaaa cgacggcttt tagtacctcc gccgtaacac 120 cacccacagt gggtcggttc tggtccatgg tggggatggt gtggtggttc cgatgatacg 180 ggaatcgctg gagaagcgtt actgatgcaa tgcactggat accgttcctg ttcagatcat 240 tgagtactcc aggcggcatt tctattgtgg ttacaatagt aagtaaggag tagtaaaagt 300 tattctgaaa ttatataaac ggcttgttgg ggttttaaaa atgttgccgg ttttagattt 360 agcagtgact ccaaccatct gatggggaac tttgagcaag tgagctccaa tagttttggc 420 gtcgcttcca aaaagctctg gaaaagcttt tatcaacagg cttgccaaaa tccgctatac 480 tagcatatgt aaaagaaaaa cttgtatacc ctaccaatag gcatacatcg catcaggact 540 tatttaacca acaaaaataa aacacaacat gaatgtacat tctggtttaa tcgctttatt 600 taacttcaac tttgaaattc atgtcgcatg gcttaacttg gttttcacag acgttcaggt 660 atacataagc tgacatatac acagtaaata ctctaacaac attaaacata tgtatgtaca 720 taattaacta gtccgtagaa acgtattatg accatacact caaaataaat gcgcatagct 780 cctaatctct atatttcact accgaactaa ttgatttaga tccgatatag aatttgacaa 840 cgtttccgaa agagagccta agagagctgg aaagtactta acgtaaaagc tttgacttgc 900 gagtatttcc tcaggggtca ccccttaccc ctttcgcatc cttgtgatcc tcttccagtg 960 gactttcctg ctgatcccgc ttcttttccg accgcgaagg tcaactctcc gcgctggtcg 1020 ccagaaggga cggcgaggag gtggtcagac ccactggaac cgattcctcc tgagcctggc 1080 ccatgggcgg tggtgatgga gtgggcgtgg aggccgtgga cgacgccgtc gatgaggtgg 1140 gacgggcggc gtgaggctgg aggaagtgaa acaagttgga atgctgcatg aaactgccca 1200 ccgatctcag cggactaaaa aagttctctg tgggatggtt ggctggctgc ggatgctgtg 1260 gaagtacaga ggactcctga tccctgcaga gattactgct gggctcgtcg tggacccctc 1320 gtcccttagc gatggagcta cagttgcagg atcggctctt cttcagcgaa ctccgagtga 1380 atgccgtgcc ctttcgatac ttaggcttgt gcccatttga gccgggactc gcctcactat 1440 cgatcacaaa gataccggat tgctcctggg gagcaggact cgccgtggat cctggcaggc 1500 agtgagcgct attggagttg ccagcaagca gtttggccct cagaagagcc ggaagtgggc 1560 catttgtggg agatgtttga gtggagagcg gtctctccct ggactgttca tctatgggaa 1620 gatcctgatt gttgcccatt ggcctggagt ccgtgtcatc cgatcgcaat ttctccctca 1680 tgaccaaagc cagggagcga cgcagttcca cgggatctat gccaggctga acgggatttg 1740 gaacagagct ggccggcacg aatacgtcct caaactccag atcatcatca tcttcgtcct 1800 catcctggct gaaactgtag ttgtggttgt cataggaggc ggacggaact gagggcttcg 1860 caggagcagg aggagctggt gggactgtgg aactgctatt tcgttcactg ctgcgctggg 1920 aacccggagc gggggaaggg aactcgtagc tggtttcacc cagctcggcg ccactggagg 1980 cctccactat gttccacatt tctcgctcga gatctgtggt caccgaagcc acggcggcca 2040 ccgtttggtt gatgttgttg aaacagggcg acaccactcc gcacttgggc aggagctggg 2100 agttcttcag ggcctcctgc tgctgcctca accaaatggg tgaatctgca gggaatgtta 2160 cgagagttat agggattttg ccacagttcc aaggagacaa cgcgcactca cactcaccca 2220 catagaggcg cggctgcgtg gagcgcatat tggagtccat ggactgcagg cgatgctgac 2280 tggccaccga gaagcggtgg attgcctccg cctgctgatc aatgtccacg cccatcatct 2340 tcaggagtaa gttcttcagc gcggccctga agtccttgag gtgataggca tacaggaccg 2400

147 gatttaccgc cgagttcaga tgggacagaa tgatgcagaa gagcgtcagc ttgggatgca 2460 catagcagtc gggacagaag gccttgatgc agttgatcgt atagagcggt atccagcaga 2520 tcataaagaa cagcacgata atggacagat tctgggtggc cttgacgtcc cgcttccttg 2580 cggcgcccaa gacccgcagc atggttcccg tgtgtccacc tcttccgggt gtcgtcacct 2640 gcaccacggc cgccgaggag cgacgactga gatcggaggc ggggttcatc gtaacaatct 2700 gacggacctt taaagttcaa ttgaaaacgg atagttaata ttccaaactc tatggaatat 2760 ataaaaaact ttactggcga aaatctatct accactcacc tgtttgatga tgacccggta 2820 gatgtgcgtg tagaaggcca gcatcagcag agccggagtg ataatggtgg caaaatagag 2880 gaagacgagg tagttgtagt ccatcacctc cacgaagaga cactcctggt tgtgattgac 2940 atcggcgtgc cagccgaaaa gcggcaggaa gcccactatc gtcccggcca cccagcacat 3000 ggagatgatg actgcaacgg aagaggaaca ttggtaatca gagtgccctg aactgaagcc 3060 cttgaagtgg agctccccca gacgtcattt gagcagattg caggaatccc tgccgtcttc 3120 gccaccaagc accataaaaa cttttatcga attgcgggaa actaaacaaa actggcaggc 3180 agggtgagtg cacttcccaa atgacgcaaa taattaccaa ttttccggac gtagcatatt 3240 ggaaagtaat cttgccttga gcggccattt ataaagcact atatagtagg tgatatatag 3300 tgcttagaaa attatatatt tatgagatat ttttagctag aggccaatta ttctgattcc 3360 aaacagttgc tataaacatc taatatgaaa attcttagaa tcaatttgaa tctagttagg 3420 ctagtaagac tattatgtta cggattttaa ggatgtttat tactgtgtac tgttctcatt 3480 gcgtccattc gtggtagttc aaatgaggcg tcttttgttt aactcaagtc gcaactcaaa 3540 catggtcgat ggccggaatg aaacacaatg tgctgtatat tagccatcca gagtcattag 3600 tatcacggca acaaaggcac aatactaaac aatggacaac ttaaagtcga aatagtttga 3660 caaatatcct gacaagtagg tgaaaccaga aaactggtcc tttaaagtgg gttttagcat 3720 accattttgt acctactgat tttatacaat acattgtata tacccccata tatacttaca 3780 tatcgccgtg cgggtgcgga cattccttga gtaggccatc ggatatagga tggcccagta 3840 tcgatccacg gacacggcca ccagacagaa gatggagatg gtacacagca ccacgagcag 3900 ggagactgtg aagaggcagg catgaaggtt tctgggtagt cccatggagg ccaggatggc 3960 gaagggaata cccaatgcgc ccactagcaa atcggccatg gccagggata ctatgtagta 4020 gttggtgcgg cgtcgcaact ttctttcccg gcggaagacg atgatcacca gcacgttgcc 4080 gatgatgctg acgatggcca ccaggacctc gaagacggtg tagggtatgt tcagctcgga 4140 actggggctg tccgagtcct tggcatcctt gctcgtggtg gccgcgtgca gcggtagcag 4200 aggtccctcg aaggagaaat cggtgatcga gaagtagcga aacgcggaca tggtgggcgg 4260 tgttgcgggt attttacggg ttccacgggg ttccctgccc cgatcgagta tttaaggcta 4320 gtgccgagct aatgaaaggg cggaacaggt gtgggcttca attacagtgc ccgctggcct 4380 gtgaactccc taattgactt gaggtggccg tggcagtagc agcgatagta atagcacatg 4440 ctgcgcattg cgtatacgcc atgcccgccg cgctgcggtt gctcctttcc cgctttctcg 4500 cttttccgat tcgctttttt cgctctcgct ctttattttc ctttccgttg atgtatttgt 4560 ttttctgctg tcgacgtacc ctattaagct ggaaaaaaaa gggaaaactt aatcatcgtt 4620 cggcacgttt gttacacaca tgcagcaact taattgtagc aattttttag tgtaataaat 4680 tgataaatat ttgccaaaaa atacatgtcc atattgataa cgtgtgcggc gagcaaaaca 4740 acaaaggccg tatcacaact atgcaatacc ctagataatc ggccagtact tgagtatatt 4800 atttgaaagg ggccatcagt tgcaggtctt ccttaaagcc agcagctcaa ggatcacagt 4860 gaaatatgtt ggaacttcga tggcttttac gatgatggtg tttctggttt ggcttatggg 4920 gtatatatac ccgcaactct gcgagtacac actgccacac tatctgattc gcgtgcggca 4980 aatacaaagc tcgaaaagca aacaactccc gactagcaac aaaatcaatt gccagacaat 5040 cgaaccgggc gctgcagaac ataataaaag tgtataaaaa ggacggaaca gcgagaacaa 5100 cgcagaaaca gacgtcccat aaataaaaga gcatcctaca cagagaaaaa agaattaggc 5160 aggggtttac gaaaataatt catattcaat tcaaaagtat tcgctttttt tgtaattatt 5220 aagatagatg atgtattgct cctaaaaact c 5251

<210> 110 <211> 2325 <212> DNA <213> Drosophila

<400> 110 atgtccgcgt ttcgctactt ctcgatcacc gatttctcct tcgagggacc tctgctaccg 60 ctgcacgcgg ccaccacgag caaggatgcc aaggactcgg acagccccag ttccgagctg 120 aacataccct acaccgtctt cgaggtcctg gtggccatcg tcagcatcat cggcaacgtg 180

148 ctggtgatca tcgtcttccg ccgggaaaga aagttgcgac gccgcaccaa ctactacata 240 gtatccctgg ccatggccga tttgctagtg ggcgcattgg gtattccctt cgccatcctg 300 gcctccatgg gactacccag aaaccttcat gcctgcctct tcacagtctc cctgctcgtg 360 gtgctgtgta ccatctccat cttctgtctg gtggccgtgt ccgtggatcg atactgggcc 420 atcctatatc cgatggccta ctcaaggaat gtccgcaccc gcacggcgat attcatcatc 480 tccatgtgct gggtggccgg gacgatagtg ggcttcctgc cgcttttcgg ctggcacgcc 540 gatgtcaatc acaaccagga gtgtctcttc gtggaggtga tggactacaa ctacctcgtc 600 ttcctctatt ttgccaccat tatcactccg gctctgctga tgctggcctt ctacacgcac 660 atctaccggg tcatcatcaa acaggtccgt cagattgtta cgatgaaccc cgcctccgat 720 ctcagtcgtc gctcctcggc ggccgtggtg caggtgacga cacccggaag aggtggacac 780 acgggaacca tgctgcgggt cttgggcgcc gcaaggaagc gggacgtcaa ggccacccag 840 aatctgtcca ttatcgtgct gttctttatg atctgctgga taccgctcta tacgatcaac 900 tgcatcaagg ccttctgtcc cgactgctat gtgcatccca agctgacgct cttctgcatc 960 attctgtccc atctgaactc ggcggtaaat ccggtcctgt atgcctatca cctcaaggac 1020 ttcagggccg cgctgaagaa cttactcctg aagatgatgg gcgtggacat tgatcagcag 1080 gcggaggcaa tccaccgctt ctcggtggcc agtcagcatc gcctgcagtc catggactcc 1140 aatatgcgct ccacgcagcc gcgcctctat gtgggtgagt attcacccat ttggttgagg 1200 cagcagcagg aggccctgaa gaactcccag ctcctgccca agtgcggagt ggtgtcgccc 1260 tgtttcaaca acatcaacca aacggtggcc gccgtggctt cggtgaccac agatctcgag 1320 cgagaaatgt ggaacatagt ggaggcctcc agtggcgccg agctgggtga aaccagctac 1380 gagttccctt cccccgctcc gggttcccag cgcagcagtg aacgaaatag cagttccaca 1440 gtcccaccag ctcctcctgc tcctgcgaag ccctcagttc cgtccgcctc ctatgacaac 1500 cacaactaca gtttcagcca ggatgaggac gaagatgatg atgatctgga gtttgaggac 1560 gtattcgtgc cggccagctc tgttccaaat cccgttcagc ctggcataga tcccgtggaa 1620 ctgcgtcgct ccctggcttt ggtcatgagg gagaaattgc gatcggatga cacggactcc 1680 aggccaatgg gcaacaatca ggatcttccc atagatgaac agtccaggga gagaccgctc 1740 tccactcaaa catctcccac aaatggccca cttccggctc ttctgagggc caaactgctt 1800 gctggcaact ccaatagcgc tcactgcctg ccaggatcca cggcgagtcc tgctccccag 1860 gagcaatccg gtatctttgt gatcgatagt gaggcgagtc ccggctcaaa tgggcacaag 1920 cctaagtatc gaaagggcac ggcattcact cggagttcgc tgaagaagag ccgatcctgc 1980 aactgtagct ccatcgctaa gggacgaggg gtccacgacg agcccagcag taatctctgc 2040 agggatcagg agtcctctgt acttccacag catccgcagc cagccaacca tcccacagag 2100 aactttttta gtccgctgag atcggtgggc agtttcatgc agcattccaa cttgtttcac 2160 ttcctccagc ctcacgccgc ccgtcccacc tcatcgacgg cgtcgtccac ggcctccacg 2220 cccactccat caccaccgcc catgggccag gctcaggagg aatcggttcc agtgggtctg 2280 accacctcct cgccgtccct tctggcgacc agcgcggaga gttga 2325

<210> 111 <211> 774 <212> PRT <213> Drosophila

<400> 111

Met Ser Ala Phe Arg Tyr Phe Ser He Thr Asp Phe Ser Phe Glu Gly

1 5 10 15

Pro Leu Leu Pro Leu His Ala Ala Thr Thr Ser Lys Asp Ala Lys Asp

20 25 30

Ser Asp Ser Pro Ser Ser Glu Leu Asn He Pro Tyr Thr Val Phe Glu

35 40 45

Val Leu Val Ala He Val Ser He He Gly Asn Val Leu Val He He

50 55 60

Val Phe Arg Arg Glu Arg Lys Leu Arg Arg Arg Thr Asn Tyr Tyr He 65 70 75 80

Val Ser Leu Ala Met Ala Asp Leu Leu Val Gly Ala Leu Gly He Pro

85 90 95

Phe Ala He Leu Ala Ser Met Gly Leu Pro Arg Asn Leu His Ala Cys

100 105 110

Leu Phe Thr Val Ser Leu Leu Val Val Leu Cys Thr He Ser He Phe

115 120 125

Cys Leu Val Ala Val Ser Val Asp Arg Tyr Trp Ala He Leu Tyr Pro

149 130 135 140

Met Ala Tyr Ser Arg Asn Val Arg Thr Arg Thr Ala He Phe He He 145 150 155 160

Ser Met Cys Trp Val Ala Gly Thr He Val Gly Phe Leu Pro Leu Phe

165 170 175

Gly Trp His Ala Asp Val Asn His Asn Gin Glu Cys Leu Phe Val Glu

180 185 190

Val Met Asp Tyr Asn Tyr Leu Val Phe Leu Tyr Phe Ala Thr He He

195 200 205

Thr Pro Ala Leu Leu Met Leu Ala Phe Tyr Thr His He Tyr Arg Val

210 215 220

He He Lys Gin Val Arg Gin He Val Thr Met Asn Pro Ala Ser Asp 225 230 235 240

Leu Ser Arg Arg Ser Ser Ala Ala Val Val Gin Val Thr Thr Pro Gly

245 250 255

Arg Gly Gly His Thr Gly Thr Met Leu Arg Val Leu Gly Ala Ala Arg

260 265 270

Lys Arg Asp Val Lys Ala Thr Gin Asn Leu Ser He He Val Leu Phe

275 280 285

Phe Met He Cys Trp He Pro Leu Tyr Thr He Asn Cys He Lys Ala

290 295 300

Phe Cys Pro Asp Cys Tyr Val His Pro Lys Leu Thr Leu Phe Cys He 305 310 315 320

He Leu Ser His Leu Asn Ser Ala Val Asn Pro Val Leu Tyr Ala Tyr

325 330 335

His Leu Lys Asp Phe Arg Ala Ala Leu Lys Asn Leu Leu Leu Lys Met

340 345 350

Met Gly Val Asp He Asp Gin Gin Ala Glu Ala He His Arg Phe Ser

355 360 365

Val Ala Ser Gin His Arg Leu Gin Ser Met Asp Ser Asn Met Arg Ser

370 375 380

Thr Gin Pro Arg Leu Tyr Val Gly Glu Tyr Ser Pro He Trp Leu Arg 385 390 395 400

Gin Gin Gin Glu Ala Leu Lys Asn Ser Gin Leu Leu Pro Lys Cys Gly

405 410 415

Val Val Ser Pro Cys Phe Asn Asn He Asn Gin Thr Val Ala Ala Val

420 425 430

Ala Ser Val Thr Thr Asp Leu Glu Arg Glu Met Trp Asn He Val Glu

435 440 445

Ala Ser Ser Gly Ala Glu Leu Gly Glu Thr Ser Tyr Glu Phe Pro Ser

450 455 460

Pro Ala Pro Gly Ser Gin Arg Ser Ser Glu Arg Asn Ser Ser Ser Thr 465 470 475 480

Val Pro Pro Ala Pro Pro Ala Pro Ala Lys Pro Ser Val Pro Ser Ala

485 490 495

Ser Tyr Asp Asn His Asn Tyr Ser Phe Ser Gin Asp Glu Asp Glu Asp

500 505 510

Asp Asp Asp Leu Glu Phe Glu Asp Val Phe Val Pro Ala Ser Ser Val

515 520 525

Pro Asn Pro Val Gin Pro Gly He Asp Pro Val Glu Leu Arg Arg Ser

530 535 540

Leu Ala Leu Val Met Arg Glu Lys Leu Arg Ser Asp Asp Thr Asp Ser 545 550 555 560

Arg Pro Met Gly Asn Asn Gin Asp Leu Pro He Asp Glu Gin Ser Arg

565 570 575

Glu Arg Pro Leu Ser Thr Gin Thr Ser Pro Thr Asn Gly Pro Leu Pro

580 585 590

Ala Leu Leu Arg Ala Lys Leu Leu Ala Gly Asn Ser Asn Ser Ala His

595 600 605

Cys Leu Pro Gly Ser Thr Ala Ser Pro Ala Pro Gin Glu Gin Ser Gly

150 610 615 620

He Phe Val He Asp Ser Glu Ala Ser Pro Gly Ser Asn Gly His Lys 625 630 635 640

Pro Lys Tyr Arg Lys Gly Thr Ala Phe Thr Arg Ser Ser Leu Lys Lys

645 650 655

Ser Arg Ser Cys Asn Cys Ser Ser He Ala Lys Gly Arg Gly Val His

660 665 670

Asp Glu Pro Ser Ser Asn Leu Cys Arg Asp Gin Glu Ser Ser Val Leu

675 680 685

Pro Gin His Pro Gin Pro Ala Asn His Pro Thr Glu Asn Phe Phe Ser

690 695 700

Pro Leu Arg Ser Val Gly Ser Phe Met Gin His Ser Asn Leu Phe His 705 710 715 720

Phe Leu Gin Pro His Ala Ala Arg Pro Thr Ser Ser Thr Ala Ser Ser

725 730 735

Thr Ala Ser Thr Pro Thr Pro Ser Pro Pro Pro Met Gly Gin Ala Gin

740 745 750

Glu Glu Ser Val Pro Val Gly Leu Thr Thr Ser Ser Pro Ser Leu Leu

755 760 765

Ala Thr Ser Ala Glu Ser 770

<210> 112 <211> 4314 <212> DNA <213> Drosophila

<400> 112 gagccaattc ttttttggct ttacgtgacg ttggcagaac aaatcgtttt tgttttagcc 60 atctgacttg tttgctcctt tatggcccgc tgcgctttgg actttgacgc atttgcgtcg 120 ctttaatgcg attgctggtt gctcattacg gccaatcctt actagtactt gcactttctg 180 tgaattcgtc tggggtttcc atttggctga ttgcattttc ataacaattt ggaggattac 240 taatgcgcca cgttgtccct gcatttgcat gaccttgaac cagtagccac ctcattagaa 300 tttcatttgt agtcaacaag gcgcagacga cagggccaca atcgataaaa acccaaatgt 360 attttatggc caaattacat ttttactaga atgaatccat agaaagatgc ggaaaataag 420 cgggcgcgga atatgctaag ctttatttgc agccatggga ataatcttaa tacagcaaat 480 tcatccttta aggtatctct agaagtaagt ttagtaagcg aactttgtcc gtcatttcca 540 ttgagttgaa tgctacattt tcgaaatctt attttaaatg cgattcaata caatatacag 600 aatctactat gtttaagatc gcaacatttt tttttacact ttcttaacta aacactttaa 660 aagcacatct gtgttacact ttggtatgca tgtgaaacat ttggttaact aaaacatata 720 tctacgcaat ttaaaaggcg atctattaaa tttcaagggg caagcttttc gtttttaaat 780 ttaattccta tatttaaatg gtgggcgttc actagtgatt gatttatgct taccattatc 840 gataatatta ttaagttata tccgcctcag gcttgtttaa gagtaaatcc cccgagctct 900 gaccaaagtt taattttaag agcgccagta tgctgaatag tatgagtcaa aagattgaat 960 attcttagac tgaataattc tgaatacttg aaagactagt ttaggagttt ttccagccgt 1020 tgtccgcagc tgaatgaatg aaaaacttaa tgcttaaggg agagtgtgcg ctcgactgtg 1080 attaactttt aattgccaaa tgcaaatgaa tgcaaaagca gtttaaacaa aacgctttgg 1140 tagcagcagc aatagcaata gacgacaaat aactggctta aacagaattc aaataaatta 1200 gcatcaggaa gccgcacgag agagtgagtt cgagtttatc agttagttga cttggacacc 1260 gatcatggcg tactgagcgg cgactggcgg cttgttcgtc ggattctgga tgtggagtac 1320 acatagagag agagagagag agagagagag ccagttaata tcgaacctat ccattgatta 1380 tagggggcac ttgcctgcat tatcgacggt ttcggctgct ccgccgactc aatggagaag 1440 cgctgcgttt gactggaatt ggttagtgcc ctcctcaggc ggcgcgattc gatgttgttt 1500 cgcgaattca gcgaaccctt cgataccttc ttgccaaaca gaacggccta aaggagtggg 1560 aaatcggtaa ggtaattagt taaatagaaa aattcagaca ttcgaattat taataaatat 1620 attaataaat atatataaat atttataata cagataaatt tgaaatatag tattgcgcat 1680 actataaccc ccacttccgt tttactcacc ttgaatgcct ctcggaactt gtggctcata 1740 atgttatata acagcgggtt gatgcaggtg gacaagtagt agaggacacc ggagacatag 1800 gtcatcaccg tgtagacaaa ctcgtgctga tcccgcagtt tggccccccg tgcaggggcg 1860

151 tagatggcaa tcagtcgctg ggcgtggaag ggggcccagc agaggaagaa gcacaccacc 1920 acggccacta aaggggaggg gggggcggta aaagtcagtg acgtggggat gaaaatggaa 1980 tggcaatgga aatggggaag acacagcgag agtcacagat aaagagtcaa cgattatatt 2040 ttttggtaat cgcaattgtc atcataaatg gagagtgcca aaatgacaaa cgcagtaaat 2100 tggctgcaga cgggttgatt agcccagctt agggcatatg gtcaaacagt tggcatacac 2160 tgagcaaaag ttgaagtaaa gcttctaaaa tggttcttca ttgcatataa agaaagattt 2220 agatatcata tttcagaatt tttaatttgc aagacttttg tgagaagact aaaccttatt 2280 aaaaacggag tcttctactt ttgtttttgt caaaatttct tactaattta atcatctgaa 2340 tactattaag tcatgtttac ttaatggtta gcggtttaga gatctgtcat ttaatttgtg 2400 atacccccgt actattgctg gtatttttcg ccagtgtata tcgtgctata attacctagc 2460 atcctgagta ctcgccgggt gccatagtga ttgagccgac ctctcaccga gctaagttga 2520 gcccccgagc cgcccatcaa gcccgctgtc cctgctccac ttcctccgcc gttgaaactc 2580 atagcggtac cggatccacc atagcgatat aggatcgtat cactgggcac actcttcagc 2640 tgctgccgtc tggcaaccga ggcaggaccc tccaccaaag tggatcgata caggtgcaca 2700 ccgataagta ggtacaacac taggataata gacatcggag ccaggaagaa tatgaacgtg 2760 gacagctgga atgagtgctt cactatgacc cgcactatgc cgcattgctc cactcccgaa 2820 tagtgctcga ttccaaattg ggcagcctgc ggaatggccg taactatggc cataatccaa 2880 accaggacga tgatgcgaat ggcgcgactg agtttactca tggcctggcc cagaaacgga 2940 tggcaaatgg caatataccg ctccaccgtg aaggccgtaa tcgttagcac cgtggcattc 3000 gccgatgtct ccgccaacag accacgtccg atgcagatgt actccccaaa cacgtacggg 3060 tacttggacc agatgtagga cacctcctgc ggaacgcccg acaacaggag caggaaatcc 3120 gagatggcca gcgaaaagag gtagtaattc gtggccgtgt gcattgaacg gttcttctta 3180 atcacaatgc aggtacttat gttgcccact acaccggtta tgaaaatgag ggagtagacc 3240 accgttacgg gtatcacgat ggccagcgga tcgcgtggcg gtccaagatc atggctcata 3300 ttgccagcgg acatggcgcc ggcggcctgg aatttttccc cttttgtttt cacaaaattt 3360 ccactaacag cgctaaattc cactgccgtt taactgctgc ggctccggct gcgactcgat 3420 gtcccctcaa ctatgctaat tataataatt tattggaggc gaccgggcgg aggagggaca 3480 ggtctggact cgcgcttcgc aatgctagat actcgattct aagattcaga tactcgactg 3540 gcacgcaaac gcaccaaatt accgacgagg tcgagatccg tataccgtat tcagtattca 3600 gtattccgta ttcccggctg tttttctagg gggcccgact tctcttcaat aagttatcga 3660 gttaatttga tttcgattcg aattctgatt cccgagagca gcctgcaacc gcactccagc 3720 gcgctccaaa cttatctgat aagccgcggc gacatttcat tcagatttgt atctgtatct 3780 gaaagccagc gacgaagcgt cgctgttttt ccctcacatg aacgcggaag gtgagcgaca 3840 tggttgtaat gaccgagcgt ccagcgaacg tgccggctca attaaatctt gaaaagcggc 3900 gatatcttga tgggactagc cgatgttaga gactaagcac aatggctccg aatacaacgc 3960 aatttttggg taattaaaaa ggctaattaa caaaaacttg taataatgtt tgctttggcc 4020 catttataaa acacttagtt gggaattttg actttgtgat gcacataatc ctaaataaac 4080 cacgataatg taaacaacac atcttggaat taaaagccaa aataagatgc aataatatta 4140 gatgatgcaa taataccaaa tgaccgaagg ccaccgtgcg tatgagtaat gtccagccag 4200 cttacttgtt agcttataag taagaatatt gttctttgtt tatcttacta aagtatattg 4260 aaatgtaaac aaataataat aattacaatt caaatctaat ttagattaat taaa 4314

<210> 113

<211> 1287

<212> DNA

<213> Drosophila

<400> 113 atgtccgctg gcaatatgag ccatgatctt ggaccgccac gcgatccgct ggccatcgtg 60 atacccgtaa cggtggtcta ctccctcatt ttcataaccg gtgtagtggg caacataagt 120 acctgcattg tgattaagaa gaaccgttca atgcacacgg ccacgaatta ctacctcttt 180 tcgctggcca tctcggattt cctgctcctg ttgtcgggcg ttccgcagga ggtgtcctac 240 atctggtcca agtacccgta cgtgtttggg gagtacatct gcatcggacg tggtctgttg 300 gcggagacat cggcgaatgc cacggtgcta acgattacgg ccttcacggt ggagcggtat 360 attgccattt gccatccgtt tctgggccag gccatgagta aactcagtcg cgccattcgc 420 atcatcgtcc tggtttggat tatggccata gttacggcca ttccgcaggc tgcccaattt 480 ggaatcgagc actattcggg agtggagcaa tgcggcatag tgcgggtcat agtgaagcac 540 tcattccagc tgtccacgtt catattcttc ctggctccga tgtctattat cctagtgttg 600 tacctactta tcggtgtgca cctgtatcga tccactttgg tggagggtcc tgcctcggtt 660 gccagacggc agcagctgaa gagtgtgccc agtgatacga tcctatatcg ctatggtgga 720

152 tccggtaccg ctatgagttt caacggcgga ggaagtggag cagggacagc gggcttgatg 780 ggcggctcgg gggctcaact tagctcggtg agaggtcggc tcaatcacta tggcacccgg 840 cgagtactca ggatgctagt ggccgtggtg gtgtgcttct tcctctgctg ggcccccttc 900 cacgcccagc gactgattgc catctacgcc cctgcacggg gggccaaact gcgggatcag 960 cacgagtttg tctacacggt gatgacctat gtctccggtg tcctctacta cttgtccacc 1020 tgcatcaacc cgctgttata taacattatg agccacaagt tccgagaggc attcaaggcc 1080 gttctgtttg gcaagaaggt atcgaagggt tcgctgaatt cgcgaaacaa catcgaatcg 1140 cgccgcctga ggagggcact aaccaattcc agtcaaacgc agcgcttctc cattgagtcg 1200 gcggagcagc cgaaaccgtc gataatgcag gcaagtgccc cctataatca atggatagct 1260 gcggacaacg gctggaaaaa ctcctaa 1287

<210> 114 <211> 428 <212> PRT <213> Drosophila

<400> 114

Met Ser Ala Gly Asn Met Ser His Asp Leu Gly Pro Pro Arg Asp Pro

1 5 10 15

Leu Ala He Val He Pro Val Thr Val Val Tyr Ser Leu He Phe He

20 25 30

Thr Gly Val Val Gly Asn He Ser Thr Cys He Val He Lys Lys Asn

35 40 45

Arg Ser Met His Thr Ala Thr Asn Tyr Tyr Leu Phe Ser Leu Ala He

50 55 60

Ser Asp Phe Leu Leu Leu Leu Ser Gly Val Pro Gin Glu Val Ser Tyr 65 70 75 80

He Trp Ser Lys Tyr Pro Tyr Val Phe Gly Glu Tyr He Cys He Gly

85 90 95

Arg Gly Leu Leu Ala Glu Thr Ser Ala Asn Ala Thr Val Leu Thr He

100 105 110

Thr Ala Phe Thr Val Glu Arg Tyr He Ala He Cys His Pro Phe Leu

115 120 125

Gly Gin Ala Met Ser Lys Leu Ser Arg Ala He Arg He He Val Leu

130 135 140

Val Trp He Met Ala He Val Thr Ala He Pro Gin Ala Ala Gin Phe 145 150 155 160

Gly He Glu His Tyr Ser Gly Val Glu Gin Cys Gly He Val Arg Val

165 170 175

He Val Lys His Ser Phe Gin Leu Ser Thr Phe He Phe Phe Leu Ala

180 185 190

Pro Met Ser He He Leu Val Leu Tyr Leu Leu He Gly Val His Leu

195 200 205

Tyr Arg Ser Thr Leu Val Glu Gly Pro Ala Ser Val Ala Arg Arg Gin

210 215 220

Gin Leu Lys Ser Val Pro Ser Asp Thr He Leu Tyr Arg Tyr Gly Gly 225 230 235 240

Ser Gly Thr Ala Met Ser Phe Asn Gly Gly Gly Ser Gly Ala Gly Thr

245 250 255

Ala Gly Leu Met Gly Gly Ser Gly Ala Gin Leu Ser Ser Val Arg Gly

260 265 270

Arg Leu Asn His Tyr Gly Thr Arg Arg Val Leu Arg Met Leu Val Ala

275 280 285

Val Val Val Cys Phe Phe Leu Cys Trp Ala Pro Phe His Ala Gin Arg

290 295 300

Leu He Ala He Tyr Ala Pro Ala Arg Gly Ala Lys Leu Arg Asp Gin 305 310 315 320

His Glu Phe Val Tyr Thr Val Met Thr Tyr Val Ser Gly Val Leu Tyr 325 330 335

153 Tyr Leu Ser Thr Cys He Asn Pro Leu Leu Tyr Asn He Met Ser His

340 345 350

Lys Phe Arg Glu Ala Phe Lys Ala Val Leu Phe Gly Lys Lys Val Ser

355 360 365

Lys Gly Ser Leu Asn Ser Arg Asn Asn He Glu Ser Arg Arg Leu Arg

370 375 380

Arg Ala Leu Thr Asn Ser Ser Gin Thr Gin Arg Phe Ser He Glu Ser 385 390 395 400

Ala Glu Gin Pro Lys Pro Ser He Met Gin Ala Ser Ala Pro Tyr Asn

405 410 415

Gin Trp He Ala Ala Asp Asn Gly Trp Lys Asn Ser 420 425

<210> 115 <211> 5927 <212> DNA <213> Drosophila

<400> 115 ttaagccaca aaatgattga aaggaaatgt tgtggggtaa aagtaaaatt ctcagatcga 60 tgagtacaat gtactatgta cttccctcgg cagctcctgc tgtgttcctt cagccgtttg 120 tgtctgtttg tccctaaagt aattaaaagt aagtaaagca aagtcacccc ctcgtcggtg 180 ggcgtggctg tccagtgatt tgccacccgc aacgattttt ttttccagta ctttcctttt 240 tttctttttt ttgcgtttat gcaaatggcc gctgaccaaa agaattaatg cgtcccgaaa 300 gtgagttgaa ttggaatgag ccgcaattct cggagtccaa aaactgcggg cagcctgtca 360 gccgtctgtt ttcacttctt ttgcgggcgg gacgaaacat caacgaatgt caatgaattt 420 acaggggaat gctataaaaa gcccgaccaa acaaaaaatg taaagcccgt aattccccat 480 tgtctcagtg cgttgctaat ttggccatat ctttaaatag ccagccgaac ggaaaggaat 540 catttgtaat ttaaagtcca attattgtgc catttgaggg gaaaactgtg gcatgccagg 600 gaatggaatg cctcgtaagc cacatcgctg cacttcatta aattgacgag acaaaagatc 660 tctacacata caataatgga aaatatttgt tccacaataa aaggggttga ggaggcactt 720 tgtgttaatg cccaacagct gcaaatctcg gtctgcggcg gccttaaaaa tagagaaatg 780 aagatggacg gtccgatgat gatccgcttg gctgaaatta ttctgtaaat tctacctatt 840 tatatcgtaa atatagattt tgatgctgat gccgatgctg cgcgagtaaa accaaattcg 900 gcccacgcgg cgtatgcgcg tttttcgcac ttaactcatt aaaacgtttg ccgctggccc 960 attgaaattt aatgggaaaa cacgcgctgt tttttttttt ttagaaattc gcctcaatag 1020 attaagctcg taaattattt aattgcattc ttgatttttg atttgaaatc aaaacattcc 1080 ctcatttaaa aactcattag gaatagcaat ggaaacgtgg ttgagcggat gtttatattg 1140 tagaaaaaaa aaatatatat atatcaaata tatgaaaaag gttttgaagt ttgtcagtca 1200 ataaatcaat ataaagcccc acttaaaatt acgacacaaa agtttccatc aaacgaaatg 1260 caaacgaaaa caatgctctg aaaatatttc atcgatatat tgaccgagca ctcagatgtc 1320 gtcacttgaa ggacccttct cgtccagccc ccgagtgcac caaccccact caccttgtag 1380 aaggccttcc ggaaattctc ggagaggaag gcgtagagca gcggattgat acacgagctg 1440 ctgtaggcca gagtctgggc ggtgacctgg atgactagct tggtgagggt gttcgtctcg 1500 atgacatcca gtgacttgag cagcaggatg agctgttcaa tcaaacgaaa gaatatgttt 1560 gattatttaa aatatatgtg ggtttcatat gtattattgc gtctcacctg gacaggcagc 1620 cagagcgagg cgaaggcgat gaccaccacg acgacgagtc gggtgacccg cttgcgaccg 1680 cgctgcgact ccttggacat gcggacgccg gttccctggc gccagagccg catgatcatg 1740 cgcatgtaga gaccgctgat gatcatcagg ggcagcaggt aggagctgat gaagaaggtg 1800 acctggtagg tgcgcggacc aaggaagtcg ttcgtcgtga aggtgcacat gccgtaggtg 1860 atgttcttct ttgcatcgta atccacctgc ggatatcgat gagaatgtgg ttgtgggaac 1920 tatgaagaaa cgtgtgcggt gtgggaatcg aatattgcgc atacgtcatg ttggcggtga 1980 cagttgcatg gcagccaagc aacgtcaaac ggccaacagc cagacatcgt aaataaaact 2040 aaactgtcat acgaatagtt cggacgtcga caactaactc gcaatctcac tttgtttctc 2100 tgtcgctgac atttggctga caaattgttc agccggagtt ttggatttgg ataaaagcgc 2160 aatgggtatg ggcaatcggg ctttcgaggc ttgttgtttg ggggatggag aatctattgg 2220 tctgttggct agacgagact ggtttgctga cgcttaggag ggtcgtaaac tgcccggtga 2280 atcgtaaaaa tattcgcagc cttttgttta catttttgtt tacaatctcc gccccttcac 2340 cgcgctttca atcgatgaat gcgtgtggaa aattgcattt aaaaaatctt cccattaatg 2400

154 ccggcatgaa ttgcttacaa aaatgtttgt ttatggcccg cccttgtttt cgttacactg 2460 agcgagcgat gttggcccac aaattgagtt cgaactctga atctgcgcag cgtcaagtgg 2520 ccaaggccac agaagtagac aaatcatggc cagaccctcc gctgatttat gggttcattt 2580 cgctggcatg ttctccgcaa aacccaacga cttcatagac ttgacaagcc attaatgccc 2640 tttcctcgtt cgcgagaaat cagccaacag ctgtcaatca atgccatgac ctggagatcg 2700 catatctagt tacgcagtcg gacatatgtg catttatgat tattatttga tatcgatttc 2760 taataaaaag ataatggcac acgctctcac aggctcattt gatatgcata taccaagcat 2820 gtagctgggc aatgtaatat ggaaataatt aatagcaaac tgttaattaa catgttgatc 2880 aaacatgact taattatgcc tttttatcgc ctgttccttt gtatttgcac acgcagacac 2940 cagataacaa agcaaagcac acatatgagc attcaatgtg ggctctattt ttccagctta 3000 atccttagac aaagcaaagc aaacacataa acaaacaata atgccaccca ttggagcact 3060 ctccccaatg cgaacaaaaa ccgaacgaga caaaaataac aatataacga agcgtgaaat 3120 gccatttaat aaaatattag gttacaataa caacaccggg agcaacagtg ggccattgcc 3180 atctcacaga taaaaaaagt tcatcatccg tgtgaagatg agattcgttt aattaaccgc 3240 gactgtcgct tttggccaag gaaaagggga aacacaacgg cacaaacaaa aagttggtca 3300 tgtgtgatgt gggaatcgct ttattggcac tgggaaatca gtggaaaaag cccgcgggcc 3360 atttatgagt atcaacagaa attggaacca atgtccgacc ataattacgt gtagttgata 3420 ctcgcaatga aaaaatatga tagatattca gtattaaata gcactcaaca attgtttgaa 3480 ctgtaccgga aaattgaata ttagttaata atcccagtgt tttcttgcga ataaaaactt 3540 aaggttaaag tctgcaaata caaatacatt gtatatcctc aaaatcgccg gtaaattccc 3600 cttttcattt ttgatatcac ccgctgatct cgagcaaaac aattccgatc ttcgtcgatt 3660 attccgcaat taaattgttt ctcgcacttt tcgcatcgat cataaaagcc taatgtccaa 3720 gatgagcatt tcaaggtcgc cacccgcgaa gacatttatc atacgcagtg tgcgcccaaa 3780 gttcgcaagt gcaaagtttc cataatggcc gcttgttacg acttacgact gcccatgatt 3840 tacgcgcttt tggatcaaca gttgaatttg aaattttgca agccacacgg agaggaggtg 3900 ggcagatatg ggcagatacc gcccagttgg caagtgtttc tcgctggcta tctggtctat 3960 aattaaaaat ttatgaattc aaaatagcaa attagtaaca aaaacaaatc gggcgccgcg 4020 catcgcgaaa ttttcaatat aaacacaaaa cagaaaataa gataaaatgg ggatacttta 4080 ataggggcat atagtaaaaa caaatgagtt gtatcaggat cagtcgattg gacgatcgct 4140 ggtttgtgcg gggtcttcgc tttctggatt acgatctggc agaaggcaga ccatctatct 4200 aggtatctat agctacatta gaaccaggca gtcggcacca ttgacgtgca gcgagaggaa 4260 tctaacgagg tgacgatgat ggaaagcaat aaatttgcct ggcccgtgtt cttcacagca 4320 aattcaggca cagcaggccc acttatagca ttctacccac tcctcccact cttccactcc 4380 cacttaccac cacgtcgtgg gtgaaggcca ctggcaccga aacgaccagc accacgatcc 4440 acagagtcac gatggcaatc agggtaatgt tctccgtcct catcatccgc gagcgaatgg 4500 gatgaaccac cgccaggaac cgatcgatgg acatcagcac cagcgtgtaa atggaggcga 4560 aggcggtcac cacaatcagg tactggacac tgcggcacca gaaccttcca tatggccagt 4620 agtacaccat gtaatcggtg gccgtgaagg gaatgcagag gattacgaac atcagatcag 4680 cggcagccag attgacaatc atcaggttgg tggtggagcg catgttgttg ttgaagacca 4740 ccaccaggat gaccagcagg ttgccgaaga atcccgtgat ggcgatgacg ccgaagaaga 4800 atcccactat ccacggcaaa gtgccattga tggccagcca ctcttcgtcg gtgaagaatg 4860 aggtgatatt ctcctcattt ctggttgcat ttaggctaat attagccagc attgtggtgt 4920 tctccatgtt ttctcagctt tagtgcacaa ctttccggtt cactttgtac tggctattgg 4980 cgatttcgct tgattgtcac gggacatttt caattttggg ctctttttcg ctcacagttc 5040 atcgaacgca aataacaaat ttccaattag gagagtttca caaagcagcc gccacaaaaa 5100 ttcaattatc atgcggaata ctacgaccgt tgagcttcgg agacctcaaa aacgtttcgc 5160 atacgccgtg tggtatcgaa ctcgaccgga attgttcgca acgtggcggg ggcaaaagca 5220 atttggtcct tccacgataa cggtaattgt aggtgggtag cacaggtaag acaacaataa 5280 aggacagcac acaaggatca cggtgaggcg aaaggcaaga gagtgagttt aaaggtgagg 5340 gcacgtgcaa acgacaccga cacagccaaa ctgtgccgag tcacaccctg acgacaagga 5400 caccggggtg tccttaggtt cgaggaccac gttgctgcac ctacaccata aattcaatat 5460 gatgtcttcc tttcgctgcg tttctgttta catttctcgt ttgctttttt attgacaaac 5520 gaacggcata aattttgggg ctataaggct atggccaaaa aaccacgttc ctattgttgc 5580 taccgactgc tgcgccgcgg tacgctatat attttcgatt ttatactgct gcttttggcc 5640 aattcgatag tccacactgc tcgcgtccgt atccagcgcc caactgattg ctggctgagc 5700 ttgttgagga atacttcgat gcctcggcgg cggcaaaacg ccggcagcga cgccagccat 5760 cccagcaaga ataatggcaa caatagcaac aaccagcgca gctggcatct gtgcgtgtga 5820 tggttttggg tggccgccgg agccacctct tcctcctcat cctcctcatc cgatcccaat 5880

155 ccccatcagc tgggctggaa tgtttgctct tgttgctccc accgcta 5927

<210> 116

<211> 990

<212> DNA

<213> Drosophila

<400> 116 atggagaaca ccacaatgct ggctaatatt agcctaaatg caaccagaaa tgaggagaat 60 atcacctcat tcttcaccga cgaagagtgg ctggccatca atggcacttt gccgtggata 120 gtgggattct tcttcggcgt catcgccatc acgggattct tcggcaacct gctggtcatc 180 ctggtggtgg tcttcaacaa caacatgcgc tccaccacca acctgatgat tgtcaatctg 240 gctgccgctg atctgatgtt cgtaatcctc tgcattccct tcacggccac cgattacatg 300 gtgtactact ggccatatgg aaggttctgg tgccgcagtg tccagtacct gattgtggtg 360 accgccttcg cctccattta cacgctggtg ctgatgtcca tcgatcggtt cctggcggtg 420 gttcatccca ttcgctcgcg gatgatgagg acggagaaca ttaccctgat tgccatcgtg 480 actctgtgga tcgtggtgct ggtcgtttcg gtgccagtgg ccttcaccca cgacgtggtg 540 gtggattacg atgcaaagaa gaacatcacc tacggcatgt gcaccttcac gacgaacgac 600 ttccttggtc cgcgcaccta ccaggtcacc ttcttcatca gctcctacct gctgcccctg 660 atgatcatca gcggtctcta catgcgcatg atcatgcggc tctggcgcca gggaaccggc 720 gtccgcatgt ccaaggagtc gcagcgcggt cgcaagcggg tcacccgact cgtcgtcgtg 780 gtggtcatcg ccttcgcctc gctctggctg cctgtccagc tcatcctgct gctcaagtca 840 ctggatgtca tcgagacgaa caccctcacc aagctagtca tccaggtcac cgcccagact 900 ctggcctaca gcagctcgtg tatcaatccg ctgctctacg ccttcctctc cgagaatttc 960 cggaaggcct tctacaaggc gaatttctaa 990

<210> 117 <211> 329 <212> PRT <213> Drosophila

<400> 117

Met Glu Asn Thr Thr Met Leu Ala Asn He Ser Leu Asn Ala Thr Arg

1 5 10 15 Asn Glu Glu Asn He Thr Ser Phe Phe Thr Asp Glu Glu Trp Leu Ala

20 25 30 He Asn Gly Thr Leu Pro Trp He Val Gly Phe Phe Phe Gly Val He

35 40 45 Ala He Thr Gly Phe Phe Gly Asn Leu Leu Val He Leu Val Val Val

50 55 60 Phe Asn Asn Asn Met Arg Ser Thr Thr Asn Leu Met He Val Asn Leu 65 70 75 80 Ala Ala Ala Asp Leu Met Phe Val He Leu Cys He Pro Phe Thr Ala

85 90 95

Thr Asp Tyr Met Val Tyr Tyr Trp Pro Tyr Gly Arg Phe Trp Cys Arg

100 105 110

Ser Val Gin Tyr Leu He Val Val Thr Ala Phe Ala Ser He Tyr Thr

115 120 125 Leu Val Leu Met Ser He Asp Arg Phe Leu Ala Val Val His Pro He

130 135 140 Arg Ser Arg Met Met Arg Thr Glu Asn He Thr Leu He Ala He Val 145 150 155 160 Thr Leu Trp He Val Val Leu Val Val Ser Val Pro Val Ala Phe Thr

165 170 175

His Asp Val Val Val Asp Tyr Asp Ala Lys Lys Asn He Thr Tyr Gly 180 185 190 Met Cys Thr Phe Thr Thr Asn Asp Phe Leu Gly Pro Arg Thr Tyr Gin 195 200 205

156 Val Thr Phe Phe He Ser Ser Tyr Leu Leu Pro Leu Met He He Ser 210 215 220

Gly Leu Tyr Met Arg Met He Met Arg Leu Trp Arg Gin Gly Thr Gly

225 230 235 240

Val Arg Met Ser Lys Glu Ser Gin Arg Gly Arg Lys Arg Val Thr Arg 245 250 255

Leu Val Val Val Val Val He Ala Phe Ala Ser Leu Trp Leu Pro Val 260 265 270

Gin Leu He Leu Leu Leu Lys Ser Leu Asp Val He Glu Thr Asn Thr 275 280 285

Leu Thr Lys Leu Val He Gin Val Thr Ala Gin Thr Leu Ala Tyr Ser 290 295 300

Ser Ser Cys He Asn Pro Leu Leu Tyr Ala Phe Leu Ser Glu Asn Phe

305 310 315 320

Arg Lys Ala Phe Tyr Lys Ala Asn Phe 325

<210> 118 <211> 7383 <212> DNA <213> Drosophila

<400> 118 atcttttaag taaaaagcgc tcaagtcaaa acttttactt tcatttaaaa gtaaattttc 60 ttgatgtttc aaatttatag caaaatgcca taatttcagt tcgtttgaaa caaacgaaat 120 gaagcggaaa ttgcgaaccg aatttattcg tacaatttat gggccacaca tgaacaataa 180 taattcattc ggctgcatgt aattaagaat aataaaaata ctggtatatt ttgtttgttt 240 gcttaatgac tcgaaatgtt tattcgtttt cgtttggtaa ttaaatacaa taataattac 300 attaataagc ctttctgttt tttaatgaca aatattgtac attacatttg cttacatcca 360 gctgtgtgct tgtgtaggat ttaatacata atcggattgt tgttaaaata ctatttaaat 420 aatttaattt aatgctactt aattgatttc aggtgctaat ttaatttgat tcattttttg 480 ttcagctaat aatacatttg atttggtgag ttttggtttg agtttgataa ggtcattaac 540 gaatcgatta tttacaacgt ttggacttcg tgctttaagg atcgcaattt gaagatacca 600 ttattataat actgtacacg gctcacgacc agcattcaca ctcattcaat atatatcctt 660 ctgcgaaaca attatcagca atgggacttg taatcacaat tcattaagac gaaatcacag 720 aggcaaatgg tcatgttcca atgacacatt tagttgcggg atatctaaac actgtaaagg 780 ggttttacta aagccttaca tacaattaca ataaaattta aacatattag tgtagtagct 840 ataccctaat aatagtcatt cactaaaaca ttaacacaca tacgttaaat gaatgagcta 900 tgacagccaa tttactggaa tacacatcat atgtgaatgc cgactggctg cggaatgtgt 960 cattggaaca cggctataac ttagatcgct ctagtttaaa ttaaagtggt tgccacaagg 1020 acttgcccgc atccttgtcc ttcgcctgcg agccgggcag gtggactcgc gacacctcgc 1080 tgagtatgca ggtgccatcg cattcggttt ggctgccaaa ttcctgttcg caaatgcagc 1140 tggagctctc cctgcttagc agggccaact ggactccggc cccggatgcc aactcctcgc 1200 tggggggcgt ggttgatggc agctccatga gtgccacgtc gtcctcgcat tcgattacgt 1260 tcggatgcag aggtttgaag ttgtttcgcc gccacggcgg cattgcaacg ccaacacctg 1320 gtgccgaaac acccggagtg gccgcaaagg taaccacgct ttgatgctga tgatgttggc 1380 cattgacatt gttgttctgc ccactacttc cgttgtaaat gccgctgtta gcaccggatc 1440 catgcacccg cggcatatgc aagcccggct tcccattgtt gacaccacca cgcgccggac 1500 caaagagatt actccggatt cgcatcgagg agttggcgta ggttgacctt atggagctgg 1560 cgcgggtgtg catcgaaaag gtcctttcgt gggcgtccat gctcgtcttg aacttgcaga 1620 aacaggccgc aaatcgcttg ttgaattccc gcttaaattt ttcctgtgca gagaaaaata 1680 gacgacggtt taggttaatc catcccaata acatatcact aaagtaagcg aaagtacttt 1740 tattcactta aatacaaatt aaagtgcatt gcataaatca taaacctctt agcaaagttt 1800 atcatttgca aaaatacatt ttttcgctat caaactttct ggttaattat tatgtgaatt 1860 ggcagaaaat ttttcgtgaa aaagcgaaaa ctgccccggc tacggcatct ttctggctaa 1920 tgaaagtgct ctaggcaaac ctccatcttc gctgacaaat cccatttgtc ttcgctgaca 1980 gtaaaataga atatctgttg acaaagtttt tcacgcacag ccagcagggg aaaaagttta 2040 cgagtttatt cggagatctg gctctcaatc tatcttttac agacaatttg agtgtcaaag 2100 caaacagccg acgggttttt tcccgctttt atcggtttgc cactttggca ttctgaggat 2160

157 ttttgtggat ttcgcttcag ttttgcggtt tcacaatttc tgcggcccag acggtaggtg 2220 tttgcttatt ggctacagtg gagcgctgct ttaattaact ttgacaaagt atttttttgt 2280 gtcagctatt ttaggtgcga ggcgaaaaga aattggaaat tgtttcaaag taaggcagaa 2340 gttatttttg attaaaaaaa aagtgacgcg tatgcttata aatcagcgag aaggaaaatg 2400 ggaaaacatc aacaaagcaa tcgattcgct tacaatgaaa ttaagttaga catatttcat 2460 tcttttttaa gcttctttga tttttgagac catgaaaact tccgtaaaag tttcatttgc 2520 tttgcgtcta tgtttgtgtt tcatttgatg agataataga aaaagctaat tttggaagca 2580 cgtgcaaagg ctttttttct tttaggtcta aaagtacgaa aataatatag aaaaaattac 2640 tttttttact ttaacttcat tattaaaagc aagacgttaa gtatgtagat attttgacga 2700 gacatccaat tgtacgcaag gcaagttttc ccaagatccc ctgtcaataa ctgactcacc 2760 caaacttaag ttccccaaaa ctaacccaag gcgaccttga gtccctcatc aatccccaca 2820 tttccccggc aaatttacca cacatttata gacttatgtc tttttagtgc gtgtgcaaag 2880 aacgtgtccc tgagcacgaa caaacatcca aaggatgtca atcaaatccc agccagacaa 2940 atgcaaattt aacactccgt aaacaaatca tcatcatcat tggagcccac acttacattg 3000 tagatgccat aaataaaggg attgtagcag ctattgctca tggccagcca atcgcagcaa 3060 aaccagacga tgctaatgaa gtggtagtcg ttgatttccg gtatcgtgac atacagaata 3120 ttatagagct gcagtggcag ccagcagagt ccaaagataa tgaccacgat aatcagcatt 3180 ttgatgacct gcaagcgtcg cagaaaaagg aaattaaacc cagtcccgat ttgcatacca 3240 catcaacgtg caaaactcac cttcttcttg tttttcaaca gcgttatgtc ccgtgaatcc 3300 tgtgcgttac caggagcacg tgtgccccac aatcgtaccg ccatctggat gtagacaaag 3360 ctgatgacac agaatggaac cagatactgc acaaaaacca gggtgtagcg aaaggattgc 3420 aattgatcat cggataggtt cttgttcatg cagaatggcc gcgtcacatt gtaggtctca 3480 ttgttctctg ttcaaaggat gaaattcagt taaggtcgct ggcacttaat ccatgcaagt 3540 tgacgtattg acttaccgcg aaatctttcg gtcaactcct ccacacgaaa ggcaatggca 3600 aagggcaccg caaatagcag ggccagcatc caaattccac caattatgaa cttcgatacg 3660 aacttggtgg gacgtgccct gcatgcgtaa gccgattttt aatgattatg attgacgaat 3720 cgaatcgttt cgaatgtggg agcccactct cccccccagc gactcaccta agtggattaa 3780 tgatggccct atgccgatcg attgcaatgg cggtcagcgt gaataccgag acatttacac 3840 tcagggcctg gacgaagggg cagaagctgc acatgaacca cggcaggttc caactctgca 3900 gcagggcagc ctggaactac acggaatgaa aatattgcaa ttattagttt aaagtattgc 3960 agattatcag aaacaacttg actatacaac tatgcctaac ctttagcctg agcatgatgt 4020 ttacaaatca caaataatcc ctttaaaatg ttcactatat atatattcat tttaattaaa 4080 gtgtaaggaa ataggatagc tacaagtgag tcgtccgcct gaggtttgat atgatttaat 4140 caacccaaaa ttgcgactcc attcaagtca cacggcaaac accattaatg aacagtggaa 4200 catgtcgggg gtgttgtatt ttcggccagt ttcaacattt cgtcgacaaa taaacgctcg 4260 aaagcccagc ggtgttgttt tggacactga tttgcgcagg agtgagtgaa aaagtgtgtg 4320 tgtgattact gcggatattt gaagaccgcg ctttctccgt tctccacaca aagtcggccg 4380 caaattgcaa tttctcgccg gcttattgat gacacttact ggcggctgtg acaggaccaa 4440 aaatctattt gattgcggca ttaatataaa ttaagtgccc aaaatgtggc tggctttggg 4500 tcaagttcaa ggttcaacga agtgtacaga ttgagcttta ttagtatgaa ttctgaggta 4560 aaaatcaatt tactattttt atttgaaaca tagaaagatg taaacaattt gtactaccaa 4620 ttaataatta tttcgactat tcagttcgat ggttacattc aatattttac gtctaaaaca 4680 agctaaaatg caattgcggc attctgcgaa acgagctgaa tacaaagtaa cgattcaatt 4740 actttattca aatgtccatt gctcattgat tgaccatttt ccgactaaac agtattttca 4800 aagcaaactg cgttcgcgtt ttgcattcga cgacaccagg gaatcaattg aagataatgg 4860 caattcaatt actcggtatc acatacaaat tccaaagaaa gcccagaaaa ctgttcacat 4920 agcttttagc actctatttt gggtacttta tagaatacaa atcccattaa cacataaacc 4980 gaaaatcaca tttaaatttg atgtaggtaa tattccatta ccacaacttt tttcgacaag 5040 atgcgcgtag gccatggcaa ttttctaatg ccaaacatga gcgctcgttg cccggaaatt 5100 aaattgatgc cggattatgc tgaaattggt gtccctgcgc actgtgggtt tcaaaaactg 5160 ggctggctac ctttctatgg tgaaaataag cgaaaactaa tgctaatgtt gttggcttgt 5220 gtgatttatg cgttaaagtc gatatccatt tactagcgca acagtgcgta tgggcaattt 5280 tgcatgtatg catttcatat ccgcgaaaaa aaaaatctcg gtaattaccc gcattataat 5340 taagcttaac tgttgcaact cacctgaaat ggtatgcaga agaggccaat aatcacatcg 5400 gcaaaagcca aattagcgat atacatattt gtcacggtcc gcatttgcct ggtcgtggcc 5460 accacccaga tgaccaaagt gttgccaatg acggccacga tactgattcc cccatagaaa 5520 atggacaaca gggccacaat ctcagcggga gccgcgtata gacgctctgt gaatgaattg 5580 aaaaatagtt gtgcattaga tttatatcac tcggaaaaag tgcttgcaac attattataa 5640 aactaaatga gatataacaa tctgttttac acaaaaattt aagaatgtat ccaatacata 5700 atgcgctcct actaagttac tgaaatttta gttatttatt acaagaccat gcttttatga 5760

158 gtgaataaat tttgtgtgtg gtgcttagct tcttccaatc cattagtttc agtgttgaac 5820 ttgtgaaaaa tcgcgcttgc tgacagaagc agattaattc aagtgtcagt tgtcagtcaa 5880 ctgatggcag gacagacgac attcacgttc ctgctgactt gtaaacgtca aggaaattga 5940 accgtatttt atagccaaag agggaatttt ataaatgcca ctttggacag tatatacctg 6000 tatatatata tacctatatc caatttaata taaaatattg atagttaaac ccaactttga 6060 tatgaatttc attagcatat ccgaacatca cctgtttcct catatcaaag tcaatgagat 6120 ggttgagccc aagtttggtc tttaaattcg gcacccccca cactcatgaa tgattcaaga 6180 tcaaagaact aacggcgaac tgtcagaaga aaaaaacact tgtcaatgtt tttgattgat 6240 gatacgtcaa gtcaatttaa tccagttgga tgagtcgcgt ccccagttgc ttgaagggat 6300 tagagagtat acttaccaaa ttctgcttcc tcctcggctc cgggcaggaa ttccaggcgg 6360 gactcctgct cgattaagtc cattgccata acactttttc gttttttagt tttagttgtg 6420 tatcctaatg aggatatgat atccttcaaa ccttgtattt tagttcgaat gctgctgctc 6480 tatgtagtgc aatacatctt caggggcttc tgagcttcat tgcaatctaa actggaaaga 6540 tataaattac agcatttgtt catttgtttt ctgaaaattc gcaaaaaagt tatctgccac 6600 aagtccagtg gtcagggaac aacaaaagtg cagacaacaa gagaaacaaa tgatctgaaa 6660 aaaaatcatt gaaaagctat acaagcaata tcagtcttgc cctcaaggaa ctgaccaaat 6720 tcagtgggcg gacatgagtt atggctcagg tggaatcacc tgtcagcttt cacaagtgaa 6780 aagtttgttc tgtataattg aaagtgcacc caaattcagt ttggcgactg agggcactgc 6840 actagaattt cgcttgtatt tcgtttctta tgaaaacagt tcatgttttc atgtttttat 6900 tgaagagtca tgccaacgct caaatgttgc cttagcctta ttgaggtggc tcctaaaaaa 6960 taaacaagaa agtcagcaag ttcattgaat gtttgagaat agaagcctca ctcaggttaa 7020 ttggccattt atcgaactgt taacattgtt gggacttgtt aatttatctt cttcagtgta 7080 aacactgtca agacttgtta atttattggg taactaaatg tttattctat aggcagacgg 7140 aattgttata gattgactta gggatgcttg taggaaatag gctgggaaat tggcgaatgt 7200 cgtgaaaaaa agatgtattt agttttgaat gactgtacta tttcccccag aaagaaacag 7260 gttcacaggc tttaagttta tatggaaatg caaaaatttg tttcgagcat taaattactc 7320 attttattat gctggtcaca agctaaaaga actaaaagga gccaccctaa cgcatgaccc 7380 caa 7383

<210> 119 <211> 1623 <212> DNA <213> Drosophila

<400> 119 atggacttaa tcgagcagga gtcccgcctg gaattcctgc ccggagccga ggaggaagca 60 gaatttgagc gtctatacgc ggctcccgct gagattgtgg ccctgttgtc cattttctat 120 gggggaatca gtatcgtggc cgtcattggc aacactttgg tcatctgggt ggtggccacg 180 accaggcaaa tgcggaccgt gacaaatatg tatatcgcta atttggcttt tgccgatgtg 240 attattggcc tcttctgcat accatttcag ttccaggctg ccctgctgca gagttggaac 300 ctgccgtggt tcatgtgcag cttctgcccc ttcgtccagg ccctgagtgt aaatgtctcg 360 gtattcacgc tgaccgccat tgcaatcgat cggcataggg ccatcattaa tccacttagg 420 gcacgtccca ccaagttcgt atcgaagttc ataattggtg gaatttggat gctggccctg 480 ctatttgcgg tgccctttgc cattgccttt cgtgtggagg agttgaccga aagatttcgc 540 gagaacaatg agacctacaa tgtgacgcgg ccattctgca tgaacaagaa cctatccgat 600 gatcaattgc aatcctttcg ctacaccctg gtttttgtgc agtatctggt tccattctgt 660 gtcatcagct ttgtctacat ccagatggcg gtacgattgt ggggcacacg tgctcctggt 720 aacgcacagg attcacggga cataacgctg ttgaaaaaca agaagaaggt catcaaaatg 780 ctgattatcg tggtcattat ctttggactc tgctggctgc cactgcagct ctataatatt 840 ctgtatgtca cgataccgga aatcaacgac taccacttca ttagcatcgt ctggttttgc 900 tgcgattggc tggccatgag caatagctgc tacaatccct ttatttatgg catctacaat 960 gaaaaattta agcgggaatt caacaagcga tttgcggcct gtttctgcaa gttcaagacg 1020 agcatggacg cccacgaaag gaccttttcg atgcacaccc gcgccagctc cataaggtca 1080 acctacgcca actcctcgat gcgaatccgg agtaatctct ttggtccggc gcgtggtggt 1140 gtcaacaatg ggaagccggg cttgcatatg ccgcgggtgc atggatccgg tgctaacagc 1200 ggcatttaca acggaagtag tgggcagaac aacaatgtca atggccaaca tcatcagcat 1260 caaagcgtgg ttacctttgc ggccactccg ggtgtttcgg caccaggtgt tggcgttgca 1320 atgccgccgt ggcggcgaaa caacttcaaa cctctgcatc cgaacgtaat cgaatgcgag 1380

159 gacgacgtgg cactcatgga gctgccatca accacgcccc ccagcgagga gttggcatcc 1440 ggggccggag tccagttggc cctgctaagc agggagagct ccagctgcat ttgcgaacag 1500 gaatttggca gccaaaccga atgcgatggc acctgcatac tcagcgaggt gtcgcgagtc 1560 cacctgcccg gctcgcaggc gaaggacaag gatgcgggca agtccttgtg gcaaccactt 1620 taa 1623

<210> 120 <211> 540 <212> PRT <213> Drosophila

<400> 120

Met Asp Leu He Glu Gin Glu Ser Arg Leu Glu Phe Leu Pro Gly Ala

1 5 10 15

Glu Glu Glu Ala Glu Phe Glu Arg Leu Tyr Ala Ala Pro Ala Glu He

20 25 30

Val Ala Leu Leu Ser He Phe Tyr Gly Gly He Ser He Val Ala Val

35 40 45

He Gly Asn Thr Leu Val He Trp Val Val Ala Thr Thr Arg Gin Met

50 55 60

Arg Thr Val Thr Asn Met Tyr He Ala Asn Leu Ala Phe Ala Asp Val 65 70 75 80

He He Gly Leu Phe Cys He Pro Phe Gin Phe Gin Ala Ala Leu Leu

85 90 95

Gin Ser Trp Asn Leu Pro Trp Phe Met Cys Ser Phe Cys Pro Phe Val

100 105 110

Gin Ala Leu Ser Val Asn Val Ser Val Phe Thr Leu Thr Ala He Ala

115 120 125

He Asp Arg His Arg Ala He He Asn Pro Leu Arg Ala Arg Pro Thr

130 135 140

Lys Phe Val Ser Lys Phe He He Gly Gly He Trp Met Leu Ala Leu 145 150 155 160

Leu Phe Ala Val Pro Phe Ala He Ala Phe Arg Val Glu Glu Leu Thr

165 170 175

Glu Arg Phe Arg Glu Asn Asn Glu Thr Tyr Asn Val Thr Arg Pro Phe

180 185 190

Cys Met Asn Lys Asn Leu Ser Asp Asp Gin Leu Gin Ser Phe Arg Tyr

195 200 205

Thr Leu Val Phe Val Gin Tyr Leu Val Pro Phe Cys Val He Ser Phe

210 215 220

Val Tyr He Gin Met Ala Val Arg Leu Trp Gly Thr Arg Ala Pro Gly 225 230 235 240

Asn Ala Gin Asp Ser Arg Asp He Thr Leu Leu Lys Asn Lys Lys Lys

245 250 255

Val He Lys Met Leu He He Val Val He He Phe Gly Leu Cys Trp

260 265 270

Leu Pro Leu Gin Leu Tyr Asn He Leu Tyr Val Thr He Pro Glu He

275 280 285

Asn Asp Tyr His Phe He Ser He Val Trp Phe Cys Cys Asp Trp Leu

290 295 300

Ala Met Ser Asn Ser Cys Tyr Asn Pro Phe He Tyr Gly He Tyr Asn 305 310 315 320

Glu Lys Phe Lys Arg Glu Phe Asn Lys Arg Phe Ala Ala Cys Phe Cys

325 330 335

Lys Phe Lys Thr Ser Met Asp Ala His Glu Arg Thr Phe Ser Met His

340 345 350

Thr Arg Ala Ser Ser He Arg Ser Thr Tyr Ala Asn Ser Ser Met Arg

355 360 365

He Arg Ser Asn Leu Phe Gly Pro Ala Arg Gly Gly Val Asn Asn Gly 370 375 380

160 Lys Pro Gly Leu His Met Pro Arg Val His Gly Ser Gly Ala Asn Ser 385 390 395 400

Gly He Tyr Asn Gly Ser Ser Gly Gin Asn Asn Asn Val Asn Gly Gin

405 410 415

His His Gin His Gin Ser Val Val Thr Phe Ala Ala Thr Pro Gly Val

420 425 430

Ser Ala Pro Gly Val Gly Val Ala Met Pro Pro Trp Arg Arg Asn Asn

435 440 445

Phe Lys Pro Leu His Pro Asn Val He Glu Cys Glu Asp Asp Val Ala

450 455 460

Leu Met Glu Leu Pro Ser Thr Thr Pro Pro Ser Glu Glu Leu Ala Ser 465 470 475 480

Gly Ala Gly Val Gin Leu Ala Leu Leu Ser Arg Glu Ser Ser Ser Cys

485 490 495

He Cys Glu Gin Glu Phe Gly Ser Gin Thr Glu Cys Asp Gly Thr Cys

500 505 510

He Leu Ser Glu Val Ser Arg Val His Leu Pro Gly Ser Gin Ala Lys

515 520 525

Asp Lys Asp Ala Gly Lys Ser Leu Trp Gin Pro Leu 530 535 540

<210> 121 <211> 4391 <212> DNA <213> Drosophila

<400> 121 agtggaaatt tcgaaattga aatggaccct ttccgccgaa aaatcgattg attttcaatt 60 tcccctctgc gctttcttgt tttgctaagt ttgaaagtta tttgctttaa ctcatgctga 120 aagaaaatat cagttgacta gccgcttttt aaccttttat tcgaatttta tccttagttg 180 ttgcacaaaa gagtctatgt gcttagttga tgatatcagt cgatatctct ttaattggcc 240 aataactgct gaatatgtgg cagcacaata tagttacgaa agtaatcggc ttaagagccc 300 acactgcgat gtgcatttta gtgcattaaa aggacttgca atgcactact gtctaatcca 360 gattacgacg acagccaatg gctttaagcg caagtatttt aaaactgaat tgtgagccgt 420 gattccagct ggagttaaat aggaaaactg ttgggcttaa agcagctgta gtggcaaata 480 ccaatcgagc atggcttcaa atcacgttca tttcgttcca catgacatga catcatggca 540 atggtatcaa agtgcacact tgtagacaca gaagcctcgg gtttgcttaa atttttatgg 600 cctcaacact taccaggtgc acagcttttc ttgccagcta ctggatgttc agtagcaggg 660 aaatcgacag ctggaagctc gagtatcaag aaaattgaga atgaatggaa aatgggttac 720 cactctcttt gttgcagaca aatttctcct tttaattgaa ggcaaaaagg gatatatatt 780 tttaaatagt tggcttctga cagagactta catgcgaaaa taaaaaattt agtattaatt 840 aaatcgactc gctgggaagt attgtcttat tttatattag aatttttaaa ttttaattta 900 gggacctata cataatggca atcaattagc ataaaatata acgttattaa tacattggtc 960 ctggaccttt gttcgtcggg gaatacgtat tttagtatat ctactgatgt gatctgctgt 1020 tgtagttggt ggatgaggtg gtcatcgact ggagctcagt ggtgcgcttt tggacatcca 1080 gctccatctt ggtggggcaa atcagaccca cccacagccg acggttcgtg gagtccaaga 1140 ggacaaagta aatgaacatc acaaatccct gcatagtggc cgtgatgcag aagaggtatg 1200 aaaaagccac acctgcctgc atgaaggcga atattccaaa gatccaggta agacccagca 1260 aaaagaagag cattatggag agtcggatct gcttaaccac cattttcttt tcgtttttat 1320 ggatgctctg gctcaaagag tgcgagatgc tgtagaaaac atacacgaat atcaccaagt 1380 tgcacacagt aatcaaggtc acagggagca ccaccccaaa aatgagacca tagcccgatg 1440 gatagcagat gccagtgtcc gtggaaagtt gggcagccga ggggacgtac gaatcgggat 1500 ctataagggc caccagcagg gtggggacca agggcagtag ccaggccaca atggcggcct 1560 tcaggatata gcgaggtggt ctctcgattc cgataactgt gacgtaacgc tggaactgca 1620 ggaaggcgat gattagcatc caactgaaga gaaccagaat ggagtactgc atggcagcgc 1680 ccagagccac acagcgaact gtgtttccat tcacaacaag cgcttcggat acatcatctg 1740 tattgagaaa cacgaagagc atcatctgga gacacatagc caggcaaagg tgcagtaaga 1800 ccttcgtgga ggcctgactg cgccagcttt tgaagagtgc ggcagtgagg aatattccca 1860 gtatacccaa aagggaaaga ctgcagccca ctatcgagat aatgtccagc actttctcat 1920

161 taatcggagt aattagaatc tcctcgccaa ggtcgttggc tcgatagctt ccacccacca 1980 ggaatgcaaa ctgtgtgagg tggttagtgt ggcactcgat gatggcatcc ttcaagaggt 2040 ccgaactgct ttcagtgctt actccctcag ttgaccaggt ttcatagttc caatatccgc 2100 atccactccc aatgctaaag gcctttgaat ccggattgcg aagattttca ttacgcagaa 2160 gaaagggcag tggcagagag agataattgc ctatttaatg gaagggtatt caaattagtt 2220 cgagtattcg aaaacaaatt ttcatgcgtt tcttacttct cagtcctggt attgaaatgg 2280 agattacttt gctgcgcggc ttacgagtgc gttgcaatga ggtttccacg aacagagcat 2340 cgtgggcata gactttaaag atgagatagg ttgctcccct gcttttcact tgccgccaga 2400 gattctccgg caaaaatgca gctgtctcca gattagattc ctccttgacc ttagccaagt 2460 cttcggagaa tcgaatgaag cggtaccaga agccactggc ggaagtcttt cgttgatccc 2520 ctggcgcaga gaatatagct aatccagtta tgcgatcgca ttcggggttg gcgaagaaca 2580 cgctgatatt gccggtaatc agagcttgga caccgatatc tgagaagttg tacgtttcca 2640 ctccagtagt ggccgtttct gcttcatcac tggtcggctt ggccaccacc ttgccgcatc 2700 tgtccttggg aaccagttgc tccggaagag catccatgta gctttcgaac tggctgagca 2760 gggaattggt agcgttgagc tgagctgata atctaagaac cttactgtcg caggacatta 2820 tctccttgca gacactgacc aagtccacac tgaccgtggc atccttgtcc tgctgcatca 2880 gggcgccgaa catttgtccg gtcatgtgaa catcggcggg tagaagattc ccacctctct 2940 gtcggaacat gttcctcatt atgccagtca tctcacgacg cccctgggtg tcattggtgc 3000 gcctcctgcc ctcgagaacg tcgtcatgca ggctattcaa gtcaccgctg atcgtgtgct 3060 ccctgaatcg cctcaaacac accacgggat cccagtgttc ggtggactcc cagttggctc 3120 ggttgtcctt cactctgcac tccctggtga ccggcattcc gtttcgcaga aggcaaacat 3180 cgtgcagggt ggcacgttcg ccgattctag cccgtttcca cttgttctgg tgaggtgttt 3240 gatcgtggtt acgcgttatg tagtcgtgct gaaactcctc cggctcgcag aacatggacg 3300 tacagtaaac cagatgtgtt tgcataagtt cgtccgatga attacgttcc tctccatcac 3360 agtactgaaa cgttccgttt ctcaagcaca tttgattttc ctttgggcag gcggaataaa 3420 tcggcgaaac caaggccaag accacaaaga gcccagcaca ccagttgaaa ttcatggcga 3480 tgaatcaggt gccacagctg tttgcagctc tccgaaaatg tttacaaatt ctttggcaga 3540 tagtactttt cacgtccgac gttcttgaaa tatcgcggca cactgagctg tctgtcgatc 3600 gattagattt ctgtagaccc cttcttcatg gtgtttgcta tcagttgcca ccacgagcgc 3660 taatcgaccc ccgttttttg tatatctaca cactactcac aaaaagacct caagtctgcg 3720 gcatttgata caatttacat tgtgattaac acgaccacgg caattgaagg cgaatccgac 3780 ggaacccttt gaggcaggga agtaacacca aacttgtgac gtcgtcttta tttgtgcaaa 3840 tagcgatttc acgccttttt accggtcttg gtacttaaaa tgctctggct gattcatttt 3900 ttacgcgctt gaattgccag ataagaagtt cttaccagga aacacggctg tacatgggct 3960 atttatacat caatgataca aaaataatgt taaaaaaaat ttaaaaactt taaaaactag 4020 ttttatttgc atccgttcaa gaaagagatt ttttttagat ttgtttgatc aattcattgc 4080 tatggcttct aataaatgtg aaatgtgaaa caccttcaca taaaaaagta tttacgcaat 4140 tcactcaagc aaaacagatc ctttgtcctt gaaaaaagtt atgaaatgca aagcacttca 4200 ccttggttgc ataaagtgcg attttcattt tgacaggcta cgcgttttca aagactcagc 4260 cttcgattat aatccacctg tactcacttc attgtaagcc agtttttggg ccaaaaagta 4320 atttttacag ccgacttcgc agcacgtaga ctgcgtgtgc tagcggaaat tgttagcttg 4380 ttgacacgtt t 4391

<210> 122 <211> 2325 <212> DNA <213> Drosophila

<400> 122 atgtgcttga gaaacggaac gtttcagtac tgtgatggag aggaacgtaa ttcatcggac 60 gaacttatgc aaacacatct ggtttactgt acgtccatgt tctgcgagcc ggaggagttt 120 cagcacgact acataacgcg taaccacgat caaacacctc accagaacaa gtggaaacgg 180 gctagaatcg gcgaacgtgc caccctgcac gatgtttgcc ttctgcgaaa cggaatgccg 240 gtcaccaggg agtgcagagt gaaggacaac cgagccaact gggagtccac cgaacactgg 300 gatcccgtgg tgtgtttgag gcgattcagg gagcacacga tcagcggtga cttgaatagc 360 ctgcatgacg acgttctcga gggcaggagg cgcaccaatg acacccaggg gcgtcgtgag 420 atgactggca taatgaggaa catgttccga cagagaggtg ggaatcttct acccgccgat 480 gttcacatga ccggacaaat gttcggcgcc ctgatgcagc aggacaagga tgccacggtc 540 agtgtggact tggtcagtgt ctgcaaggag ataatgtcct gcgacagtaa ggttcttaga 600 ttatcagctc agctcaacgc taccaattcc ctgctcagcc agttcgaaag ctacatggat 660

162 gctcttccgg agcaactggt tcccaaggac agatgcggca aggtggtggc caagccgacc 720 agtgatgaag cagaaacggc cactactgga gtggaaacgt acaacttctc agatatcggt 780 gtccaagctc tgattaccgg caatatcagc gtgttcttcg ccaaccccga atgcgatcgc 840 ataactggat tagctatatt ctctgcgcca ggggatcaac gaaagacttc cgccagtggc 900 ttctggtacc gcttcattcg attctccgaa gacttggcta aggtcaagga ggaatctaat 960 ctggagacag ctgcattttt gccggagaat ctctggcggc aagtgaaaag caggggagca 1020 acctatctca tctttaaagt ctatgcccac gatgctctgt tcgtggaaac ctcattgcaa 1080 cgcactcgta agccgcgcag caaagtaatc tccatttcaa taccaggact gagaagcaat 1140 tatctctctc tgccactgcc ctttcttctg cgtaatgaaa atcttcgcaa tccggattca 1200 aaggccttta gcattgggag tggatgcgga tattggaact atgaaacctg gtcaactgag 1260 ggagtaagca ctgaaagcag ttcggacctc ttgaaggatg ccatcatcga gtgccacact 1320 aaccacctca cacagtttgc attcctggtg ggtggaagct atcgagccaa cgaccttggc 1380 gaggagattc taattactcc gattaatgag aaagtgctgg acattatctc gatagtgggc 1440 tgcagtcttt cccttttggg tatactggga atattcctca ctgccgcact cttcaaaagc 1500 tggcgcagtc aggcctccac gaaggtctta ctgcaccttt gcctggctat gtgtctccag 1560 atgatgctct tcgtgtttct caatacagat gatgtatccg aagcgcttgt tgtgaatgga 1620 aacacagttc gctgtgtggc tctgggcgct gccatgcagt actccattct ggttctcttc 1680 agttggatgc taatcatcgc cttcctgcag ttccagcgtt acgtcacagt tatcggaatc 1740 gagagaccac ctcgctatat cctgaaggcc gccattgtgg cctggctact gcccttggtc 1800 cccaccctgc tggtggccct tatagatccc gattcgtacg tcccctcggc tgcccaactt 1860 tccacggaca ctggcatctg ctatccatcg ggctatggtc tcatttttgg ggtggtgctc 1920 cctgtgacct tgattactgt gtgcaacttg gtgatattcg tgtatgtttt ctacagcatc 1980 tcgcactctt tgagccagag catccataaa aacgaaaaga aaatggtggt taagcagatc 2040 cgactctcca taatgctctt ctttttgctg ggtcttacct ggatctttgg aatattcgcc 2100 ttcatgcagg caggtgtggc tttttcatac ctcttctgca tcacggccac tatgcaggga 2160 tttgtgatgt tcatttactt tgtcctcttg gactccacga accgtcggct gtgggtgggt 2220 ctgatttgcc ccaccaagat ggagctggat gtccaaaagc gcaccactga gctccagtcg 2280 atgaccacct catccaccaa ctacaacagc agatcacatc agtag 2325

<210> 123 <211> 774 <212> PRT <213> Drosophila

<400> 123

Met Cys Leu Arg Asn Gly Thr Phe Gin Tyr Cys Asp Gly Glu Glu Arg 1 5 10 15

Asn Ser Ser Asp Glu Leu Met Gin Thr His Leu Val Tyr Cys Thr Ser 20 25 30

Met Phe Cys Glu Pro Glu Glu Phe Gin His Asp Tyr He Thr Arg Asn 35 40 45

His Asp Gin Thr Pro His Gin Asn Lys Trp Lys Arg Ala Arg He Gly 50 55 60

Glu Arg Ala Thr Leu His Asp Val Cys Leu Leu Arg Asn Gly Met Pro 65 70 75 80

Val Thr Arg Glu Cys Arg Val Lys Asp Asn Arg Ala Asn Trp Glu Ser 85 90 95

Thr Glu His Trp Asp Pro Val Val Cys Leu Arg Arg Phe Arg Glu His 100 105 110

Thr He Ser Gly Asp Leu Asn Ser Leu His Asp Asp Val Leu Glu Gly 115 120 125

Arg Arg Arg Thr Asn Asp Thr Gin Gly Arg Arg Glu Met Thr Gly He 130 135 140

Met Arg Asn Met Phe Arg Gin Arg Gly Gly Asn Leu Leu Pro Ala Asp 145 150 155 160

Val His Met Thr Gly Gin Met Phe Gly Ala Leu Met Gin Gin Asp Lys 165 170 175

Asp Ala Thr Val Ser Val Asp Leu Val Ser Val Cys Lys Glu He Met 180 185 190

Ser Cys Asp Ser Lys Val Leu Arg Leu Ser Ala Gin Leu Asn Ala Thr

163 195 200 205

Asn Ser Leu Leu Ser Gin Phe Glu Ser Tyr Met Asp Ala Leu Pro Glu

210 215 220

Gin Leu Val Pro Lys Asp Arg Cys Gly Lys Val Val Ala Lys Pro Thr 225 230 235 240

Ser Asp Glu Ala Glu Thr Ala Thr Thr Gly Val Glu Thr Tyr Asn Phe

245 250 255

Ser Asp He Gly Val Gin Ala Leu He Thr Gly Asn He Ser Val Phe

260 265 270

Phe Ala Asn Pro Glu Cys Asp Arg He Thr Gly Leu Ala He Phe Ser

275 280 285

Ala Pro Gly Asp Gin Arg Lys Thr Ser Ala Ser Gly Phe Trp Tyr Arg

290 295 300

Phe He Arg Phe Ser Glu Asp Leu Ala Lys Val Lys Glu Glu Ser Asn 305 310 315 320

Leu Glu Thr Ala Ala Phe Leu Pro Glu Asn Leu Trp Arg Gin Val Lys

325 330 335

Ser Arg Gly Ala Thr Tyr Leu He Phe Lys Val Tyr Ala His Asp Ala

340 345 350

Leu Phe Val Glu Thr Ser Leu Gin Arg Thr Arg Lys Pro Arg Ser Lys

355 360 365

Val He Ser He Ser He Pro Gly Leu Arg Ser Asn Tyr Leu Ser Leu

370 375 380

Pro Leu Pro Phe Leu Leu Arg Asn Glu Asn Leu Arg Asn Pro Asp Ser 385 390 395 400

Lys Ala Phe Ser He Gly Ser Gly Cys Gly Tyr Trp Asn Tyr Glu Thr

405 410 415

Trp Ser Thr Glu Gly Val Ser Thr Glu Ser Ser Ser Asp Leu Leu Lys

420 425 430

Asp Ala He He Glu Cys His Thr Asn His Leu Thr Gin Phe Ala Phe

435 440 445

Leu Val Gly Gly Ser Tyr Arg Ala Asn Asp Leu Gly Glu Glu He Leu

450 455 460

He Thr Pro He Asn Glu Lys Val Leu Asp He He Ser He Val Gly 465 470 475 480

Cys Ser Leu Ser Leu Leu Gly He Leu Gly He Phe Leu Thr Ala Ala

485 490 495

Leu Phe Lys Ser Trp Arg Ser Gin Ala Ser Thr Lys Val Leu Leu His

500 505 510

Leu Cys Leu Ala Met Cys Leu Gin Met Met Leu Phe Val Phe Leu Asn

515 520 525

Thr Asp Asp Val Ser Glu Ala Leu Val Val Asn Gly Asn Thr Val Arg

530 535 540

Cys Val Ala Leu Gly Ala Ala Met Gin Tyr Ser He Leu Val Leu Phe 545 550 555 560

Ser Trp Met Leu He He Ala Phe Leu Gin Phe Gin Arg Tyr Val Thr

565 570 575

Val He Gly He Glu Arg Pro Pro Arg Tyr He Leu Lys Ala Ala He

580 585 590

Val Ala Trp Leu Leu Pro Leu Val Pro Thr Leu Leu Val Ala Leu He

595 600 605

Asp Pro Asp Ser Tyr Val Pro Ser Ala Ala Gin Leu Ser Thr Asp Thr

610 615 620

Gly He Cys Tyr Pro Ser Gly Tyr Gly Leu He Phe Gly Val Val Leu 625 630 635 640

Pro Val Thr Leu He Thr Val Cys Asn Leu Val He Phe Val Tyr Val

645 650 655

Phe Tyr Ser He Ser His Ser Leu Ser Gin Ser He His Lys Asn Glu

660 665 670

Lys Lys Met Val Val Lys Gin He Arg Leu Ser He Met Leu Phe Phe

164 675 680 685

Leu Leu Gly Leu Thr Trp He Phe Gly He Phe Ala Phe Met Gin Ala

690 695 700

Gly Val Ala Phe Ser Tyr Leu Phe Cys He Thr Ala Thr Met Gin Gly 705 710 715 720

Phe Val Met Phe He Tyr Phe Val Leu Leu Asp Ser Thr Asn Arg Arg

725 730 735

Leu Trp Val Gly Leu He Cys Pro Thr Lys Met Glu Leu Asp Val Gin

740 745 750

Lys Arg Thr Thr Glu Leu Gin Ser Met Thr Thr Ser Ser Thr Asn Tyr

755 760 765

Asn Ser Arg Ser His Gin 770

<210> 124 <211> 7986 <212> DNA <213> Drosophila

<400> 124 gtgttaatcc ccttggctta tcggtttaat ctatttataa aatcaattca aacataaagc 60 ggcgcatatc tcagcgatgt tgggtaggta accaaaagta aatacactct aattcctatt 120 gatcttgtat aaatacgagt ggatagttag ttagatatca ccattttgca ccgtgcataa 180 acataaagtg agatactcgt tttcgagaga tgcacttctg agtacccgta ttcaaatcgt 240 actctcagta gccaagtact cagtactcaa gctgtttgtc ttacgggtgt ggacgtgcga 300 gcagacactt taggagtggg atagccggag cagaccggct gaagtgtcat ccgatcgaag 360 gtcgcctcaa cagcacagcg atttcgattc cgattccaaa tccgattctt tggccatagg 420 aattcctctg ggaggtggag catgtggctg atttatttat ttcgagcgat ataaacagag 480 caatacgaga atgggcgaat ataagtttgc tcgaacggct ggtccgttcc gagctgaaat 540 tgaattgtaa atggccatat taattgggaa tcatttaaaa tttccaatga ttttttctgt 600 gttttggtgt cggcagtcta tgcatgttcg gtggcataat ttatgggcgc taattactat 660 cgccccattt tgtgtatttc gcgtgctgtc caaggccaat tacgcttact tattgcaatt 720 tatgtggcca cagtccggcc gtaattggaa attgtgtaag gtcgcaggca atttcattat 780 ttgtatgcac ttctggacgc tccggttgcc gggtctagca tttttctagc atttttctaa 840 tgacgccagc gcgtttgggg acgacgttac ctagcccagt tttccctttg cagccatttg 900 attaagtgac ctacgtttcg cccacacaga atcatcaatt tgttcatgtc gccgacggtg 960 cgaataaggt ccaacctaag tgagtgagct atccgccggc atggcggcgt tggaacatcc 1020 ggatgccatg ctgccatact ccaaattgtt gtcaacagcc ctcactgtgg ccagtggtaa 1080 ctcgaactcc tccgatggta ctttgctgct catccagacc agtgcggcac caggtggcga 1140 tgtgatggcc accggagccg gagccggaaa gttgggtgtg ccctcgatga actcgtacct 1200 ggtgagcatg gcgtggccca agtcgctggc agtggccgtc ttcctggtca tcatcctggt 1260 caccgtggtg ggcaacacac tcgtcatcct cgccgttctg accacacgcc gcctgcgcac 1320 cgtaaccaac tgtttcgtga tgaacttggc catcaccgac tggctggtcg gcacctgcgt 1380 gatgcctcca tcggtggtgc tctacataac aggtgagaat ggcagcggag ggcctgtcca 1440 tgcccatcga tggccaaaga tttatggctc tgtgggggct ttacacttcc ggggaaggtg 1500 gaatcggggc aagtgtttac tattcgaagc cctccggtgg aagttcgggt agtaaacatt 1560 tgcccaaatc gatgggggag cacatttggt cgatttcgat ttaaaataat cccacagcga 1620 aaattataaa atttctccgt tggcaaaata tacatatttt tgattgcaaa atatcttgtg 1680 agtggtgtgc gagtgtttta tgggtttcgc tggaaaacct ttgataattt tttctggaat 1740 ctatattttt agcagaattt tgaataaagc ataacaacat tagtggttaa aaattttgta 1800 taatttagta attttaaata aattatgtat ctttaataat taacatctct tatttaacgc 1860 atttcataaa tgtataaaaa gcaatcaaac atgtgatctt ttcgaagcca aatgaatata 1920 caaagtttaa tattccttgt cataacttga acaatacaaa gaagaattta tagtggttta 1980 aattgaagga tctgccagtg taatgcctcc ttaatcccgg ccaggtgcac aaaccgattg 2040 aagcacggcg acaaatattt gttctttgca ggcacttggc gctttggctg gatactgtgc 2100 gacatttgga tctcgctgga catcctgctc tgcagcggct ccatcctcag cctgtgcgcc 2160 atcagtctgg acaggtgagt tggccaacta atttcgtaat ttgccgttga tgtcatagca 2220 atgaccacag tccatagccc gttgtccacg gtcctcggtc cttagataaa gtcatggcaa 2280 ggtgcaaaaa cagtgcaaat aatttatttg ttgacgtttt tattgccgca tgaccgttgt 2340

165 cctggccatt cccagtgcat atcctttgag tgtgcgacgc cacaatggca aggattgggt 2400 tgggcttgga ttcccattca cccattccct atttccccat ttcctccatt tagccatccc 2460 accgtttgct tttgttggaa gtttcaatta cattttaatg gcatttccaa gttttgtgtt 2520 gtggctcccg agttgagctg atccagctga gccatggagc catggacctg aacctcaacc 2580 aggacaaaca ccgacgccca ctggcgttgt gtgtgccttt tggcctggcc agaaagccgt 2640 ctgcggcttt gcgaacaata tgtccgcttg gcttttgttt ttttccagca tttctctggc 2700 catttccgtt gcgtttattg gcccggcttt tataatttcc tctttttcac cttcgttttt 2760 gttttatatt tcgcaggtat ctcgccgtca cacaaccact gacgtactcc aagaagcgcc 2820 gatccaagcg actggccctc ctcatgattc tcgtcgtgtg gataactgcc ctgtcaatca 2880 catgtccacc ctatttgggc tggtaagtta gcgccagctg cacggagaac aaaatcaacc 2940 ttaacccatg atggatcgcc tattcatctg ttaagaaaac cattcatgtt ataatcattt 3000 aattgaacgc attaaattgg gttgggagta caggcaacat gtgataatga tcagtatcca 3060 aaggaagaaa aataatatat ttaatatcat ataatattat taataatatt atattataaa 3120 tatggccaag ataaatttat ttgtagtgct ctattaagtt tatagatata tatttttttg 3180 aattttgtaa tattattttc actctttccc gtgtaattcg aaatattata tgtaatattt 3240 ttattgagca cccatttttt ttttaccaaa tttgtccttc cggaggcgtg acaatacttt 3300 gtggcttttt gtggctgaaa gtcctgctcg cttttttttt tcttttttga gctaatggct 3360 gtgcggtggc gcagcataga taatgtgcta caaaagggtc tcgaaataca cacgtttatt 3420 tatattatat ttgcgccttt ggctgcgcct aaaaaacatt acgtaattga cgacgggttg 3480 ttgctgttgc tgctggtcgt gcagccatta cattgaagtt ttaatgagtt gttaatgact 3540 ttgtttgccg cggcgcattt gctttgttct cacctacgca cacacactca gcgcgaaagc 3600 cgcacacttg tgtgttgcat acttccaggc gcccaaatta accagcactc actcacacac 3660 actcgcactc actcacacac accacaaagc cagcatgtcc ttaatgccat tggccatggc 3720 ttagttttgg ccccctttgg ctgaaagcga agagcatggc ttaaagggca cattaaaacg 3780 gtctgaggcc gaattacagc cacagctgca ggacattgga aaatttggaa aatttggcgc 3840 tgggggaaaa tcgcaattat aagcgccagc agatggcgcc acttacatat tttcattctt 3900 taagcggact agttttatga aaaaagtttg caaatgcagc ggttgcaaca actgtttgtt 3960 ttactcacaa tctgttattt gttattgcct aatgaatact aaactgattg tgtttgcttg 4020 ctatttaaat ttagatttaa cttttggcta attgatttaa gcattgttta tttagttcat 4080 tttttaattt aactaatgca tagctaatgt attaaattgc cctcaatttc ggattgaata 4140 attaatgtta aacaagaagt ttagtaggaa aatcggctat ttccattcgg gtcttgtaaa 4200 taccaacctt aacaaagttg catttgtaca attatactgt caggttattt tggtatcggg 4260 tagcagtaat taccgtgagt ttttggataa cacatacttg gggtaacaag cagctagttt 4320 agttgaatta caacaccgga aaattccatt gacagtagtg acaatgaggc aataaacttt 4380 ttgaaagaga aacattatag gaaactgtgt atccagtggg cgtgccccaa actttggttg 4440 gcatatttgt aaaaattggc catccaaaaa ataaatcaaa acaactggca atcattttat 4500 aatcgtgtgg gcgtgagtct tttaggcgat tggggggctt tagagtgggc gtggtaatgt 4560 tctgaaataa gcttgttccc gagatttgga ctccggggga caaatggaca taaccgaatc 4620 aaggatatat atacttcatg cttctgtctg ctacatgata ttcagtgaac ctagtattct 4680 aagaatagtg ggtacaataa cccagtatga actggaagaa gctgaatctt gccacctaca 4740 gtggatgtat gtgacaattt gcccattttt tttactcaat tccccacagc acacgggtgt 4800 acctttagtt gacacatttg gtgtacgcca ccacattact ctgttgtctc ggaatcgttt 4860 tcttccgcat attgatttaa agtcagctcc gatttgtact gcctgaatga ccaacacact 4920 gcgatgtgca taagtaaaag gcttacaggt gggactactc tgactggctt aggtttagga 4980 tttgaattcg aatttcgccc ggcttaactc agccagttgt cattccccaa gtcccagttc 5040 cccagccgca atcacaaccg caagagccac caaaccagag caggtaccag gtacctccca 5100 catccaccac atctcacatc cttccaaccc gcaaaccgca tgcaattcga actggaattc 5160 aatttgccat tcacatccac attcgcaggt acgaggtcgg tcggcaccag gcggagttcg 5220 tggactgccg ctacaaccaa aacaagggct acgtggtctt ctcggcgatg ggatcgttct 5280 tcattcccct caccgtgatg ctctacgttt acgtgaagat tggttatgtc ctcacgtcac 5340 ggcgacagcg cattgtgcgc gatgcggtaa gctacatctc cagctccatc actatataag 5400 catatatgta tgtgtccacc actttggtgt cccctgaaat gtgtccggaa atttatcatg 5460 tcacacctaa cacatctaac cagctaacca ggggactaag ttgtcaggca ctggggaaaa 5520 agatccagga gtgcgctcaa cacttcaagt gcagatcttc attaagttgg gatacccact 5580 gggtatccca cttgagtacc agccacttat cgcacagtac tgcaggtgat attttaagtg 5640 ctgagctttg ataacagaag tccaactaat atatctaatc acaaattaaa tttgctgtga 5700 attcttggat gtaaactgaa tgaattatct tttgtttgtt agcatgaaaa atgaacttca 5760 gtgtcaataa atgaaatgaa aatgcaataa gaacactttt tgaatattta aaaagagtgc 5820 atagtagttg ataaatatat tcttttagtt tagtactaat tgaacgtttg ctgccaagag 5880 caagtgaagt aaattgtaga aagtaggtga cgtgaaatgg aacgaagtaa ttacagcaat 5940

166 ccaaatcccg aatctctatg ccctgacatg caatctaaat tattcctcac gtttttgtca 6000 gtgctctgct tacatattcc tcttctatta tgtccttcca acagtactcg gagcgcacgg 6060 cagactacga tgtggatggg gacaacttca tctcggagtc ggagcactat cattgcacgc 6120 caaccaagtg gctgccgaac aggaagtccc gctggaggtt caactccctg cacgacccac 6180 cacccagcgc cgccacgaat gcagcagcga agggacacca gtcgtccgtc aagtgctcca 6240 agtgctccaa gtgctcctct gccactggaa ctgctggagc tggagctgga gctggtgtgg 6300 tagacaaaac gctgacgttc aaacatcagc ccacctttta cgagctggtc gaggtgtcgc 6360 gtctctcgtc gctcattcac tgctcggcaa ttagctgcaa gtatggagga ccctgcatgc 6420 actccacgcc ctcgggcatg cactacgttg gcacggaggc ctccttctcg gacacctgcc 6480 tgggtggcaa tgtgagcaac aacaccacca ccaccaccac caacaccgtc gcactggaaa 6540 ccaacgagaa actggaggcg gaggccaagc aaaagcaaca gcagcaacga tcctccttcg 6600 accaccatca cccgcatgca caccatcatg gctcccatgg ccagcagagc catcacaatc 6660 atcaccatcg catgccgatg cgagtttcga ccacgaaacg tgatagcaag accgccaaga 6720 ccctgactat tgtgatgggc ggcctaattg cttgctggct gcccttcttc gtctattatc 6780 tgctgatacc cttcctgccg cgacccgccg tcctcgagga cctcatgttc ggcttcacct 6840 ggattggctg ggtcaactgc gccatcaacc cgttcatcta cgccttctac aatccggact 6900 ttcgcactgc cttctggcgg ctcacctgtc gccccatttg caagcagaag cgtccgccca 6960 accacctggc catgttccgt ggctagtttc cggatgcaga tgcagttgcg gatgcggatg 7020 cggatccgga accggtttcc gaatcactga gcacttgagt gtgtgtcata gtgccgccat 7080 ctccagtcgc acaatcgacg ctcacttggg tggtggggga aatatctcag gcatatcctt 7140 aacttttcgc cgtgctggtt caccaacttc tatgtaatta gcataaaaaa taagtggaga 7200 aactaccaac tcgcatttcg atctttttga agtacaagtt atgccaatgc aaggacatca 7260 aattgactct agactacagt acagatagta aataaaaaag aatttaagga gtattaacta 7320 caatagataa gctgtttgag aaatgcacta tctcttatat taaatcaatt gaagataatg 7380 aaaatcaaat attagcttaa caaaactgct gaatttaatt caagtttatt tcatgaaaac 7440 aaatatatag aaactagttt aaaatttatc acacatgtcc ctccaaaaat tgtaactaat 7500 attttggcaa acgaagccaa tggagggacc ttttggccaa ctcgtcgcca ctagctcacc 7560 aactaagtat tcatttgcca ggcactataa gctgtttgcc gcactctatc tgcatcgttt 7620 atgccaaacg cagctagtaa aactaagata cttatggtca atattgattg gagcaaagat 7680 tgccttgtta aacccaaaaa atcgactgcc ttttgaagct tcaaaagccg catttcgagc 7740 agcatcttaa aggtcacttt acggtcgcaa tttttttttt ttaagactca ctggacttgg 7800 ccggaagttg agattcttgc ctagaccaga tccaaatcct atatatagta ttttcctgtg 7860 tgtgagcgtt gattgtgcga ggcgagcggc acgaagcgaa acgtaacgaa acaaaagaca 7920 aattatagta tttgcgagtc tttgttgcct gacggcaact gttggccatc gggatgagtg 7980 ggatga 7986

<210> 125 <211> 1704 <212> DNA <213> Drosophila

<400> 125 atggcggcgt tggaacatcc ggatgccatg ctgccatact ccaaattgtt gtcaacagcc 60 ctcactgtgg ccagtggtaa ctcgaactcc tccgatggta ctttgctgct catccagacc 120 agtgcggcac caggtggcga tgtgatggcc accggagccg gagccggaaa gttgggtgtg 180 ccctcgatga actcgtacct ggtgagcatg gcgtggccca agtcgctggc agtggccgtc 240 ttcctggtca tcatcctggt caccgtggtg ggcaacacac tcgtcatcct cgccgttctg 300 accacacgcc gcctgcgcac cgtaaccaac tgtttcgtga tgaacttggc catcaccgac 360 tggctggtcg gcacctgcgt gatgcctcca tcggtggtgc tctacataac aggcacttgg 420 cgctttggct ggatactgtg cgacatttgg atctcgctgg acatcctgct ctgcagcggc 480 tccatcctca gcctgtgcgc catcagtctg gacaggtatc tcgccgtcac acaaccactg 540 acgtactcca agaagcgccg atccaagcga ctggccctcc tcatgattct cgtcgtgtgg 600 ataactgccc tgtcaatcac atgtccaccc tatttgggct ggtacgaggt cggtcggcac 660 caggcggagt tcgtggactg ccgctacaac caaaacaagg gctacgtggt cttctcggcg 720 atgggatcgt tcttcattcc cctcaccgtg atgctctacg tttacgtgaa gattggttat 780 gtcctcacgt cacggcgaca gcgcattgtg cgcgatgcgt actcggagcg cacggcagac 840 tacgatgtgg atggggacaa cttcatctcg gagtcggagc actatcattg cacgccaacc 900 aagtggctgc cgaacaggaa gtcccgctgg aggttcaact ccctgcacga cccaccaccc 960

167 agcgccgcca cgaatgcagc agcgaaggga caccagtcgt ccgtcaagtg ιctccaagtgc 1020 tccaagtgct cctctgccac tggaactgct : ggagctggag ctggagctgg ^■tgtggtagac 1080 aaaacgctga cgttcaaaca tcagcccacc ttttacgagc tggtcgaggt ιgtcgcgtctc 1140 tcgtcgctca ttcactgctc ggcaattagc tgcaagtatg gaggaccctg ιcatgcactcc 1200 acgccctcgg gcatgcacta cgttggcacg gaggcctcct tctcggacac <ctgcctgggt 1260 ggcaataaac tggaggcgga ggccaagcaei aagcaacagc agcaacgatc <ctccttcgac 1320 caccatcacc cgcatgcaca ccatcatggc tcccatggcc agcagagcca '•tcacaatcat 1380 caccatcgca tgccgatgcg agtttcgacc acgaaacgtg atagcaagac <cgccaagacc 1440 ctgactattg tgatgggcgg cctaattgct ; tgctggctgc ccttcttcgt i -tattatctg 1500 ctgataccct tcctgccgcg acccgccgtc ctcgaggacc tcatgttcgg <cttcacctgg 1560 attggctggg tcaactgcgc catcaacccg ttcatctacg ccttctacaa ^■tccggacttt 1620 cgcactgcct tctggcggct cacctgtcgc cccatttgca agcagaagcg ■tccgcccaac 1680 cacctggcca tgttccgtgg ctag 1704

<210> 126

<211> 567

<212> PRT

<213> Drosophila

<400> 126

Met Ala Ala Leu Glu His Pro Asp Ala Met Leu Pro Tyr Ser Lys Leu

1 5 10 15

Leu Ser Thr Ala Leu Thr Val Ala Ser Gly Asn Ser Asn Ser Ser Asp 20 25 30

Gly Thr Leu Leu Leu He Gin Thr Ser Ala Ala Pro Gly Gly Asp Val 35 40 45

Met Ala Thr Gly Ala Gly Ala Gly Lys Leu Gly Val Pro Ser Met Asn

50 55 60

Ser Tyr Leu Val Ser Met Ala Trp Pro Lys Ser Leu Ala Val Ala Val

65 70 75 80

Phe Leu Val He He Leu Val Thr Val Val Gly Asn Thr Leu Val He 85 90 95

Leu Ala Val Leu Thr Thr Arg Arg Leu Arg Thr Val Thr Asn Cys Phe 100 105 110

Val Met Asn Leu Ala He Thr Asp Trp Leu Val Gly Thr Cys Val Met 115 120 125

Pro Pro Ser Val Val Leu Tyr He Thr Gly Thr Trp Arg Phe Gly Trp

130 135 140

He Leu Cys Asp He Trp He Ser Leu Asp He Leu Leu Cys Ser Gly

145 150 155 160

Ser He Leu Ser Leu Cys Ala He Ser Leu Asp Arg Tyr Leu Ala Val 165 170 175

Thr Gin Pro Leu Thr Tyr Ser Lys Lys Arg Arg Ser Lys Arg Leu Ala 180 185 190

Leu Leu Met He Leu Val Val Trp He Thr Ala Leu Ser He Thr Cys 195 200 205

Pro Pro Tyr Leu Gly Trp Tyr Glu Val Gly Arg His Gin Ala Glu Phe

210 215 220

Val Asp Cys Arg Tyr Asn Gin Asn Lys Gly Tyr Val Val Phe Ser Ala

225 230 235 240

Met Gly Ser Phe Phe He Pro Leu Thr Val Met Leu Tyr Val Tyr Val 245 250 255

Lys He Gly Tyr Val Leu Thr Ser Arg Arg Gin Arg He Val Arg Asp 260 265 270

Ala Tyr Ser Glu Arg Thr Ala Asp Tyr Asp Val Asp Gly Asp Asn Phe 275 280 285

He Ser Glu Ser Glu His Tyr His Cys Thr Pro Thr Lys Trp Leu Pro

290 295 300

Asn Arg Lys Ser Arg Trp Arg Phe Asn Ser Leu His Asp Pro Pro Pro

305 310 315 320

168 Ser Ala Ala Thr Asn Ala Ala Ala Lys Gly His Gin Ser Ser Val Lys

325 330 335

Cys Ser Lys Cys Ser Lys Cys Ser Ser Ala Thr Gly Thr Ala Gly Ala

340 345 350

Gly Ala Gly Ala Gly Val Val Asp Lys Thr Leu Thr Phe Lys His Gin

355 360 365

Pro Thr Phe Tyr Glu Leu Val Glu Val Ser Arg Leu Ser Ser Leu He

370 375 380

His Cys Ser Ala He Ser Cys Lys Tyr Gly Gly Pro Cys Met His Ser 385 390 395 400

Thr Pro Ser Gly Met His Tyr Val Gly Thr Glu Ala Ser Phe Ser Asp

405 410 415

Thr Cys Leu Gly Gly Asn Lys Leu Glu Ala Glu Ala Lys Gin Lys Gin

420 425 430

Gin Gin Gin Arg Ser Ser Phe Asp His His His Pro His Ala His His

435 440 445

His Gly Ser His Gly Gin Gin Ser His His Asn His His His Arg Met

450 455 460

Pro Met Arg Val Ser Thr Thr Lys Arg Asp Ser Lys Thr Ala Lys Thr 465 470 475 480

Leu Thr He Val Met Gly Gly Leu He Ala Cys Trp Leu Pro Phe Phe

485 490 495

Val Tyr Tyr Leu Leu He Pro Phe Leu Pro Arg Pro Ala Val Leu Glu

500 505 510

Asp Leu Met Phe Gly Phe Thr Trp He Gly Trp Val Asn Cys Ala He

515 520 525

Asn Pro Phe He Tyr Ala Phe Tyr Asn Pro Asp Phe Arg Thr Ala Phe

530 535 540

Trp Arg Leu Thr Cys Arg Pro He Cys Lys Gin Lys Arg Pro Pro Asn 545 550 555 560

His Leu Ala Met Phe Arg Gly 565

<210> 127

<211> 3681

<212> DNA

<213> Drosophila

<400> 127 tccatgcatt tataattcaa cattcgctcg cggccttatg aaaagctcat ttggttacga 60 gtgtcctggg tccttaagtc ctttctacct cgaaagtgtt aatgagccgg caggctgccg 120 taattatgca aatttttaat gactatgaaa atggtttccg cggagcaaca agtgctcgcg 180 tcttggtcct tggatctcta tacccctcat acccctctaa aaatgccagc taattccatt 240 tgaccccaga ggccccaaag caatccattt gcatggctac caatagctcg tcgcattcgt 300 cgtaccaacc caaccatttt ccatttaatc cctacgatgt gagagctctg tactgagctt 360 actgctggca ttcggtcttt agatttatac agattttgtc aaacaaaaca tgaattcgca 420 cttttacaca catatgtgtg tctgtaaatg actgaaaggg agagcgtcga aagccgattt 480 ggtgccattc agttgaagcc ctttaggtcg tgattcgcat atggtcgagg ccatttaagc 540 tgatatcagg cacattaaat gtagtaaagg aacgtaagta tgataaaggc agcatcacaa 600 aagtgtcaag taaatgcaaa ttaacattaa tttaagactt gaattcgtct gtactgaaac 660 agtacaatta aaatataatt agctatatat ttgtaacttt taagaacgga tacttctggg 720 accaatgttt tttgaacata acagatatct accatatgaa gtgaaataaa tagaattttt 780 cgggaccatt ttgtttccag atttcaaatg aaatgaaacg catatttttg ccagtttttg 840 ataataaata tcaggggact tggccaaatt ttaatacaat ctcatttaga aaaataaaac 900 aattgcatgc cgataaaata ataagtgata ccgaaagaga gcttttgatt agagtgaaat 960 atgctcatgc ggttcagtcg agatccaaag tttgcgcaga atgcttctga atattttagc 1020 tataattctt gtattcgtaa tttcaagcca atcggaggca gttattcctg gatgtgatta 1080 cttcgacacc gtggatatat ctcatatccc aaagctaaat gactcctatg cgtacgagga 1140 gctaatcatt cctgctcatc tcacgggtct atatacattt aggcaactgg cggatggatc 1200

169 acaggagcca gtgaagagtc acttaagagc atgtatctgc aaactaaaac cttgtatccg 1260 attctgctgc ccccgcaaca aaatgatgcc gaatagtcgc tgtagcgatg gactcacaga 1320 gaatctgaag cggatcaatc cctacttgaa gatcacactg gaggatggaa ctataggaaa 1380 atattacctt ctcaccgaca tgatcgtctt aagatatgag tttcggtatt gcgagaaggt 1440 tgtttcggta caggaggatc agtacaagct atatgaggtt aagatttcaa tctttttgaa 1500 gtatctcagt ataatttgat atctatagaa tggcagcttt atgattaaac ccgatgtaaa 1560 ctggacattg agcaagcagt ggtactgcct ccatccccgt ttggaagatc cgaattccat 1620 atggatactg gaacatgtat atataccgaa gtcaatgcca gccgtacctc agggcaagca 1680 cctactatat catctaatct catctcatct aattctctga tttttccagt cggtactatt 1740 tccatggttg gttgtattct cacgattgca gtgtatctct acataaagaa actgcgaaat 1800 ttgcttggaa aatgtttcat ttgctatgta ttttgtaagt ttgtgcagta ccttatctgg 1860 gcaggaggag atttgaactt gtggaataat atttgctccc tagcaggtta gttgaatcca 1920 tattaaagtt tgacttaaaa tatgcgttta ttctaaacag gttacactaa ctatttcttt 1980 gctttggctt ctcacttttg gctctctgtt atgagtcatc aaatatggaa aaacttgagg 2040 ttaatcaatc gggatgaacg tagctatcac tttctcatct acaacatcta cggttggggc 2100 acacctgcta tcatgacggc aattacatat ctggtggatt gggcctggga ggatagacct 2160 gacaaactga attggattcc cggtgttggc ttatatcgat gctggataaa cagtgggttt 2220 tagggtagag tgtttaagcc agtttaagac cagtaattga ttttctttga acagcctatg 2280 actggtctgc tatgatatac ctatatggac cgatgctgat cttgagttta ttcaatgtgg 2340 tcacgtttat cctgacagta aatcacataa tgaagattaa gagtagcgtt aagagttcta 2400 cccaacagca gcgaaagtgt atacagaata atgagtaagc tttaagtatt tataacttac 2460 tatttctaat tccattctct tactatagtt ttctattata cctacgactg tcggtgatga 2520 tgggcgtgac tgggatttct gaggtaataa cttacttcgt caagcggcac aaattttggc 2580 gacaagtcct tcgggtgcca aattttttcc atttgggttc cggtatagtc gtatttgtgc 2640 tatttattct taagcgcagc acatttcaaa tgataatgga gaggtaagag ctttttgctt 2700 aatagatttt aaagttacta tatcaatatc attttagaat cagcggtccg aggagacaac 2760 aacctgcatc ttgatcaacc tactagttta aataaatgca aattatagat aagtgagctc 2820 ttttttttta taagtttagt atagagcagt ccctctatgg tcaataaatg cttataatct 2880 tcttattatt gaaaaattct ttattattga tatttaatca ataatatatt tttatttttt 2940 ttttttttgt tagaacaaaa tgtcaattgt catcaaaaat atgtgtttgt gaataaaatc 3000 aagttccgta ggaaaatatg cacttttatg gaaactcgct ttttcaatta gtccttgcat 3060 acgcgccagg accccaaatc cttccacctt ccccacaatc ctcggctggt gtcagaatgc 3120 aaatgcagat ttttaagcct tgcggcagct tttgcgcaaa cagattgtaa acaaataaat 3180 gccgccggca gacacacaga tactcgaaca ttcggtggtc agtggccaga ttgcagcctg 3240 aaattcattc aatactttat ctcacatgca ttgcacttca cttttgagcc acgttaagtt 3300 cagtctgccg aaaccttttt cgcacttaag tggttaaatt ggctgtgata aattgttgcc 3360 gagtcaaagt tgctgccgct gcggggcacc tcaagtcaca tgtggtgatg gtgcgagtgg 3420 gtggttgggt ggcgtgtgct tttctcctcg gaaaatgcgt gaaaagtcca caagcacaaa 3480 aagtctggga ggctggctct ctctcatctc atcacgttca ttgagtgcct gtcgctgaca 3540 gtaatcataa cgcagtcatc agctcgtaat attacggccg cctgacatat gacatctggg 3600 aaagcggaaa atgggggctc agggaccaag gaaaaggtat gcgtactatt aatatgccag 3660 tgtgtgaagg agctttcatt c 3681

<210> 128

<211> 1503

<212> DNA

<213> Drosophila

<400> 128 atgcttctga atattttagc tataattctt gtattcgtaa tttcaagcca atcggaggca 60 gttattcctg gatgtgatta cttcgacacc gtggatatat ctcatatccc aaagctaaat 120 gactcctatg cgtacgagga gctaatcatt cctgctcatc tcacgggtct atatacattt 180 aggcaactgg cggatggatc acaggagcca gtgaagagtc acttaagagc atgtatctgc 240 aaactaaaac cttgtatccg attctgctgc ccccgcaaca aaatgatgcc gaatagtcgc 300 tgtagcgatg gactcacaga gaatctgaag cggatcaatc cctacttgaa gatcacactg 360 gaggatggaa ctataggaaa atattacctt ctcaccgaca tgatcgtctt aagatatgag 420 tttcggtatt gcgagaaggt tgtttcggta caggaggatc agtacaagct atatgaggtt 480 aagatttcaa tctttttgaa gtatctcagt ataatttgat atctatagaa tggcagcttt 540 atgattaaac ccgatgtaaa ctggacattg agcaagcagt ggtactgcct ccatccccgt 600 ttggaagatc cgaattccat atggatactg gaacattcca tggttggttg tattctcacg 660

170 attgcagtgt atctctacat aaagaaactg cgaaatttgc ttggaaaatg tttcatttgc 720 tatgtatttt gtaagtttgt gcagtacctt atctgggcag gaggagattt gaacttgtgg 780 aataatattt gctccctagc aggttagttg aatccatatt aaagtttgac ttaaaatatg 840 cgtttattct aaacaggtta cactaactat ttctttgctt tggcttctca cttttggctc 900 tctgttatga gtcatcaaat atggaaaaac ttgaggttaa tcaatcggga tgaacgtagc 960 tatcactttc tcatctacaa catctacggt tggggcacac ctgctatcat gacggcaatt 1020 acatatctgg tggattgggc ctgggaggat agacctgaca aactgaattg gattcccggt 1080 gttggcttat atcgatgctg gatatggtct gctatgatat acctatatgg accgatgctg 1140 atcttgagtt tattcaatgt ggtcacgttt atcctgacag taaatcacat aatgaagatt 1200 aagagtagcg ttaagagttc tacccaacag cagcgaaagt gtatacagaa taatgagtaa 1260 gctttaagta tttataactt actatttcta attccattct cttactatag ttttctatta 1320 tacctacgac tgtcggtgat gatgggcgtg actgggattt ctgaggtaat aacttacttc 1380 gtcaagcggc acaaattttg gcgacaagtc cttcgggtgc caaatttttt ccatttgggt 1440 tccggtatag tcgtatttgt gctatttatt cttaagcgca gcacatttca aatgataatg 1500 gag 1503

<210> 129 <211> 172 <212> PRT <213> Drosophila

<400> 129

Met Leu Leu Asn He Leu Ala He He Leu Val Phe Val He Ser Ser

1 5 10 15

Gin Ser Glu Ala Val He Pro Gly Cys Asp Tyr Phe Asp Thr Val Asp 20 25 30

He Ser His He Pro Lys Leu Asn Asp Ser Tyr Ala Tyr Glu Glu Leu 35 40 45

He He Pro Ala His Leu Thr Gly Leu Tyr Thr Phe Arg Gin Leu Ala 50 55 60

Asp Gly Ser Gin Glu Pro Val Lys Ser His Leu Arg Ala Cys He Cys

65 70 75 80

Lys Leu Lys Pro Cys He Arg Phe Cys Cys Pro Arg Asn Lys Met Met 85 90 95

Pro Asn Ser Arg Cys Ser Asp Gly Leu Thr Glu Asn Leu Lys Arg He 100 105 110

Asn Pro Tyr Leu Lys He Thr Leu Glu Asp Gly Thr He Gly Lys Tyr 115 120 125

Tyr Leu Leu Thr Asp Met He Val Leu Arg Tyr Glu Phe Arg Tyr Cys 130 135 140

Glu Lys Val Val Ser Val Gin Glu Asp Gin Tyr Lys Leu Tyr Glu Val

145 150 155 160

Lys He Ser He Phe Leu Lys Tyr Leu Ser He He 165 170

<210> 130 <211> 6552 <212> DNA <213> Drosophila

<400> 130 agtatatacg agtatatcct gtacgactat atatcaaacc gaaagtcgaa ctgaaagtgt 60 cctctaagcg ggactttcat cgaggtcggt gcccctcatt atcgtattca tttgtggggc 120 tcatttgatt cattgtgtct gttcgtgtgt gttggcgtgt tactctgtta agttggatgc 180 aattctgtcg ccgatggttg tggttttgtg tccatggccc atcaatgggg atgctccatc 240 catgtggatg ggcggtcagc caactaactt ggaacattcg tatgtgatgt gtctgtggtg 300 gagggcgccg acctcgaggc ccgctagcta ctgtatccaa ttgaactgtg atttagctaa 360 ctaactctag gtaccgacac ctcgtgtcgg cgtggaacaa tccggcctct aaggatatga 420 atttctttac actcgcttac ctaatcgtac tgtgggaatc ggaaggaagg ttctgtgtgc 480

171 cgtgggtttt ggttttgggt gggaggaaaa gcttgctgct cgtgatatgt gataggttgt 540 gggagcagcc cactttgaag gacactactc tattctggta aagcgaatcg tatccttggc 600 gttttgctta cgtctacttt ggaatcataa tcgcgtgctt gctgtgtgtt gattatatcg 660 ctacttgggg tttgcttaat gtaattgtta aaaattgtac ctagcctaca gcttgcaatc 720 caccgttcat gctccacata gcatatatgt atgtatgtag tttagtggta tgtacagatc 780 tatttacata agtagctagt agaaccttaa agctattggg aaacgcaacg aacgacaaac 840 gaaacgaaac tggagcccaa ttgagatctc tgctgcaacg atggcctcca tttggcacac 900 tttgccatcc tctcccgggc tttaatccat tccacaaggg acccatcatc caattgccta 960 ttgctataac tattgctggt gacgtgctcg ccgttgataa tcaccccatg tgcatgatct 1020 tcttgaaggc cttgcgaaac tcgggattga atattgtgta gataaccggg ttcacaaagc 1080 tgttgatgta gcccagccag gtggtcatca tgtaggcggt gagcccaggt cggcagtctt 1140 tcttgaactt ggcgcacatg gcgtccatga tgttgcagct gaagaacggc agccagcaga 1200 acaggaagac acctgtttga gggtttgaag gttatatata tgatggcata tggattagaa 1260 tatggcagag cgcaaggacg tggtccaaaa cggctggggg aggtggctca acttgaactt 1320 acccaaaaca atggccaatg ttttggtggc cttgcgctcc tttttggccg acgatttttc 1380 gcgtttcttt ttcgaggcct tgtgcacctt gtatatcgtg aatctgtgcg tcacgcgaag 1440 gataataggc catggtgtgg tatatattgc attttccaca ggcaaaaaag gcaaatgatg 1500 aagagaggta gagaaggcga gaaggaaatg gggtggcatt agcatcgact ggccaacaag 1560 agcccaaata actaataact gtaattaggg gcaatggacg gcgttactca ccttgacgcc 1620 tgcgagttct tcttatcctt gcgcgaggac gttttcgatg tagtcgatag cgtcgagtcg 1680 ttgcgtgcca aagtcatggc ctcctgcact ccgtaccgca caaaggacaa tggcttcatg 1740 gcgacgctgc gaacggaagt cggtcggatt cggaatgaga acttaactgc ggcattacgt 1800 actactagtc actatttttg ggcttgccgg attgcctaca ttgccaacat gcggcttcta 1860 ttttgggggt ttcgaggata aagtggcagg tttctcgcta aacactacgt aataggtctg 1920 tgatgaaaac gtgagctctt ttttgctaag caacttaaat caagcgattg tgcaagaatg 1980 ccaccaaata atcaattgat gatttcataa gcctgctgat atgtaaacat gccgacaata 2040 attatgaaaa gtagtggcaa gtggcagaac taatactgca aatcactatt taaatgtgca 2100 attggatttc aatctgtttg aaaaatgtaa tgtgttaaaa aaaaaaaaaa catgtaatag 2160 ttgacaacaa taacccgaca tatttaatta aactttgcca tttgtttacc aattaatatt 2220 tggaagcaaa gatgttgaca tttttgacgc ggtcaaactc tttgtctgtt tttattgaac 2280 gaaaaaagcc atgcgtgtta tacgcattta ttgttttgtt tataaataat gacaattgat 2340 gtgtgcaatt taagcaattt taatatgcta cgtaatctag tgtaagtaga taaaaaaaaa 2400 cattgcgcaa aaagagcact gcctatagct gaaaaaagta ttatattatt caaaaactat 2460 gtacaaaaac ttgaatggga atgctttatt ttgtcgggct gcaaaaacag ttcattaaac 2520 ttttaaactg ttgcgaaaag tttcatttta cctatggtac aatcaaaaag aatgttgttc 2580 aatgatttag taccaatgtg gtacagatat tggacggtat tttgtttttt ttttttttct 2640 aaatattagc aatttctcga atttccgata taattgccgg aactttgatt ttaaaacaat 2700 aacttggatg aggcattatg tttttatccg tgcacgaact tctactacgc ccccaactac 2760 tggggatgct atttctaagg tggcaggctt acggatctga atgccaaata cctggagtta 2820 tcgacaccga ctgacctgag ggcgggttcg ccgcgcttcg gcgagtcgtc gccggtgggg 2880 cgccgctgac tgctgacgct ggatcgctgg agggtggcgc cactgggcag cggactgtcc 2940 ggcggcgagc cgctgctccg cggagcggct gatgtggcag cagaggcgga ggcgggcgcc 3000 acgcctgcaa ggacatcgtc aacgtttgag gctgcataac cagaatcatg attaccattc 3060 ggatcggcga cgaccagctg cggctgtgtg gtgatttggg ccacaacgct gctgcgagtg 3120 cgttatggca atgtggagcg atgtgacggt ggggttatcc aattaatggt gccgcgacca 3180 tatccatcaa tcaatcaatc aatcggcgat agacgacgag tgggcgaaga agcagcagaa 3240 tccggcgttg atgaaggacg aaaagatgga aaatcggggt gcaacgtcaa ttaaaggcaa 3300 ggcaagattg agttttaata aagtgacgca ttaattgaat tattgagaat tatttttctc 3360 tgccattggc tgtgatttct tttggcgggt aaagtttcgc ggtcttgttt gccatccatt 3420 tcagcccatc ggttcggttc ggttcggttc ggatcggatc ccatcccttt gtgcatccag 3480 cctcctgtca ttaatggttt catttcatgt ccttattgga ttaagcaggc catcaggatg 3540 ctaattggct gcgcttaacg ctcgcactta atggcggttt cggccaggaa ttgggagaaa 3600 gattcgaatg ccgtggggcg gggacatccg attgcaagga tgatgggcaa gggatccttt 3660 cggcaggacc tgattgaaag tgcagcacgc ttttatgtcg gcaattgagt gccgctgtgt 3720 ccggacgaag cctgccatta gattgacagt tttccatggg catgcaccgt ctgggggtcc 3780 attgctttgc tggtctgctg gtctggaagg aagtgcagtc gagaccactc agcagaaaca 3840 ggcttatcta ttacgtgttt ggggcacgtg ccagggctgt cagggttgtc aggttgcaag 3900 ttgcaagttg caagcggaca aggatatgga cacggaaacg aaactgctga gctccgaact 3960 tttgcagggc catcggagat agcccccagc caaacattcg ttctccaggc gatggagttt 4020 tctgcgaaat tcgccgaaag tttccgcttt tcataccccg ttcacgtaag atgtaagtgg 4080

172 gtttgcaaat gtacatatat gtccaatccg actccattgg caacgtgttt atattcgtga 4140 agtaacatta gccgccaaaa gaaggtctta cacagccaaa aaaaaacttt gtgaaacgta 4200 tatttccttt ttgtatattc caaatctgat ttaaagctat catgttctac gcatttctac 4260 acagcacatc aaagccccta aatggtatcg taaaatgagt actcacttgc ccgtctcctc 4320 gacaacggtg gccagcatga actcggtgga cttgtcgttc acgatgacgt ggcagtcgtc 4380 gatgtccggc gagatggcgt tctcgtcctc ctcctcgttg gagccgctgg ccgtgttggt 4440 ggcggcctcg tcgggcagaa tcctactggc gtggcgactg ctgtccaggg ccgtctccgc 4500 caggcgccgg gtctgggcaa tgttctcgat gacgctgccg cccgtgagtt ccgataggtg 4560 gggcttgcgg gccgcccgct gcttccgcgc tcgactcctc agcgcctgtg ggtgggtggg 4620 tacgagatgt aaaatacaga aaacagtata ccaaacatgg gacacaggat acagactacg 4680 gacgacggac cacggactac gggctgtggg acacgggatg caggatgcag gatgcaggat 4740 gcagtagaga gcggattagg cactgccatg ctgcgcttgc atcctacgga tattcgcccc 4800 cagtcagcag caaatgtgca caaacagaaa cagaaacagg aagagaaaca gaagcatccc 4860 caagccagca ttgcagatta tggatctgcg ccagcaatat tcattccact cgactcggag 4920 aaatccgatt ttaattgcgg tcttttaata atagtgcttg aaattttttt gcgcaatgga 4980 aagagcgaca gaaagaccaa agcgcggaaa attcgctcta ggaattaatg tttgtgggaa 5040 gcttggagtg ttcaaaggaa ttaacatgtt tggaatatat cgtatatata catatatcgc 5100 tcgctactca ccttgaaaat gttccagtag agaaacacca tgatgatgca gggtatgtag 5160 aagctgctca gcgaggagta gagtataaag tcggcgttgt agaaggcgca tacatcgggt 5220 tcgcggttgg gcgtgttgtt gaggcccaga actatcggcg agccgatggc agccgatatg 5280 gcccacacca gcagtatcgt aaggcaaacg cggcggctat ttttgtgctt ggcgtacttt 5340 attggctgtg tcacagcgat gtatctgtgg gatatatccg tggaatgtgt gcttgggtca 5400 tatgggtctc cgaaataggg gccgctgtga actcacctgt ctatggagat ggcaactaag 5460 ttgaatatcg atgaagtaga gcatatcaca tccatggcta tatagaaatc acaaacgacg 5520 tcaggcaggg cccaggctcc atttacctgc aaaacaaaaa gaaggagggg gggggggcgt 5580 caggtaagaa cgaggatgtg tatgtcgatg cggatgagga gcacacttca tttgttcggc 5640 acttaatcga ctcgggaatg gagctctatt ggaatgccca tcctttgtcg aatattaata 5700 acaatatttt cccatttccc gtgctgctgc cacaaattag ttttagactc tatctcttca 5760 tcgacgtctc cggcagcatc tatgttatgg cccaacccga atgcggactc cataaaaacc 5820 ccaacaaaaa cgtcaggaat ttcccaagcc aaacaatttg tagcacacaa agcacataaa 5880 aaaaggccga gtgggccacc agttcggttg gaacttaatg tggatatgtt tgggtgaaca 5940 cccaacctgt cgtggttgca ctccccatag cccgtgtacg aggtatacat aatgtagcgc 6000 caaccgattc ggtattagaa tggcatcgat agctttttgg atgtgaatac tattagtaag 6060 tagaggtagc tgtcacatag gtatttgttg actgatctgc gggtaagagg tatcgcatag 6120 tcgaatacac tcggcggagc cagtttccca gaatcagtag tttaacattt taagaagtca 6180 atatttgaat aatactacta ctacatatat tgtacttata tgccaccaat gtgtgtgtgc 6240 taactaaaat gcatgtagac ggtatcgaat agtcgaagtt aatcgaccct aacgtactat 6300 cttgtttttc ttcttcaatc ggttttgcgc ctaaattata caaacacatt gaaacttgaa 6360 gcggggctca acgcgtggga agagtgtaaa atattgatac acacgcaacc acaccacacg 6420 aaagtaaaag tgaaagtgaa agtcaagtga aagcagcata gaaatgtgct aaaatagctg 6480 ggcagtcgca gacttggaat ttcttagaac tcggatgaag actccttagc cggagctaag 6540 cgagcataac aa 6552

<210> 131 <211> 1392 <212> DNA <213> Drosophila

<400> 131 ttgcaggtaa atggagcctg ggccctgcct gacgtcgttt gtgatttcta tatagccatg 60 gatgtgatat gctctacttc atcgatattc aacttagttg ccatctccat agacagatac 120 atcgctgtga cacagccaat aaagtacgcc aagcacaaaa atagccgccg cgtttgcctt 180 acgatactgc tggtgtgggc catatcggct gccatcggct cgccgatagt tctgggcctc 240 aacaacacgc ccaaccgcga acccgatgta tgcgccttct acaacgccga ctttatactc 300 tactcctcgc tgagcagctt ctacataccc tgcatcatca tggtgtttct ctactggaac 360 attttcaagg cgctgaggag tcgagcgcgg aagcagcggg cggcccgcaa gccccaccta 420 tcggaactca cgggcggcag cgtcatcgag aacattgccc agacccggcg cctggcggag 480 acggccctgg acagcagtcg ccacgccagt aggattctgc ccgacgaggc cgccaccaac 540 acggccagcg gctccaacga ggaggaggac gagaacgcca tctcgccgga catcgacgac 600 tgccacgtca tcgtgaacga caagtccacc gagttcatgc tggccaccgt tgtcgaggag 660 acgggcaaca gcgttgtggc ccaaatcacc acacagccgc agctggtcgt cgccgatccg 720 aatggtaatc atgattctgg ttatgcagcc tcaaacgttg acgatgtcct tgcaggcgtg 780 gcgcccgcct ccgcctctgc tgccacatca gccgctccgc ggagcagcgg ctcgccgccg 840 gacagtccgc tgcccagtgg cgccaccctc cagcgatcca gcgtcagcag tcagcggcgc 900 cccaccggcg acgactcgcc gaagcgcggc gaacccgccc tcagcgtcgc catgaagcca 960 ttgtcctttg tgcggtacgg agtgcaggag gccatgactt tggcacgcaa cgactcgacg 1020 ctatcgacta catcgaaaac gtcctcgcgc aaggataaga agaactcgca ggcgtcaaga 1080 ttcacgatat acaaggtgca caaggcctcg aaaaagaaac gcgaaaaatc gtcggccaaa 1140 aaggagcgca aggccaccaa aacattggcc attgttttgg gtgtcttcct gttctgctgg 1200 ctgccgttct tcagctgcaa catcatggac gccatgtgcg ccaagttcaa gaaagactgc 1260 cgacctgggc tcaccgccta catgatgacc acctggctgg gctacatcaa cagctttgtg 1320 aacccggtta tctacacaat attcaatccc gagtttcgca aggccttcaa gaagatcatg 1380 cacatggggt ga 1392

<210> 132 <211> 444 <212> PRT <213> Drosophila

<400> 132

Met Asp Val He Cys Ser Thr Ser Ser He Phe Asn Leu Val Ala He

1 5 10 15

Ser He Asp Arg Tyr He Ala Val Thr Gin Pro He Lys Tyr Ala Lys

20 25 30

His Lys Asn Ser Arg Arg Val Cys Leu Thr He Leu Leu Val Trp Ala

35 40 45

He Ser Ala Ala He Gly Ser Pro He Val Leu Gly Leu Asn Asn Thr

50 55 60

Pro Asn Arg Glu Pro Asp Val Cys Ala Phe Tyr Asn Ala Asp Phe He 65 70 75 80

Leu Tyr Ser Ser Leu Ser Ser Phe Tyr He Pro Cys He He Met Val

85 90 95

Phe Leu Tyr Trp Asn He Phe Lys Ala Leu Arg Ser Arg Ala Arg Lys

100 105 110

Gin Arg Ala Ala Arg Lys Pro His Leu Ser Glu Leu Thr Gly Gly Ser

115 120 125

Val He Glu Asn He Ala Gin Thr Arg Arg Leu Ala Glu Thr Ala Leu

130 135 140

Asp Ser Ser Arg His Ala Ser Arg He Leu Pro Asp Glu Ala Ala Thr 145 150 155 160

Asn Thr Ala Ser Gly Ser Asn Glu Glu Glu Asp Glu Asn Ala He Ser

165 170 175

Pro Asp He Asp Asp Cys His Val He Val Asn Asp Lys Ser Thr Glu

180 185 190

Phe Met Leu Ala Thr Val Val Glu Glu Thr Gly Asn Ser Val Val Ala

195 200 205

Gin He Thr Thr Gin Pro Gin Leu Val Val Ala Asp Pro Asn Gly Asn

210 215 220

His Asp Ser Gly Tyr Ala Ala Ser Asn Val Asp Asp Val Leu Ala Gly 225 230 235 240

Val Ala Pro Ala Ser Ala Ser Ala Ala Thr Ser Ala Ala Pro Arg Ser

245 250 255

Ser Gly Ser Pro Pro Asp Ser Pro Leu Pro Ser Gly Ala Thr Leu Gin

260 265 270

Arg Ser Ser Val Ser Ser Gin Arg Arg Pro Thr Gly Asp Asp Ser Pro

275 280 285

Lys Arg Gly Glu Pro Ala Leu Ser Val Ala Met Lys Pro Leu Ser Phe 290 295 300

174 Val Arg Tyr Gly Val Gin Glu Ala Met Thr Leu Ala Arg Asn Asp Ser 305 310 315 320

Thr Leu Ser Thr Thr Ser Lys Thr Ser Ser Arg Lys Asp Lys Lys Asn

325 330 335

Ser Gin Ala Ser Arg Phe Thr He Tyr Lys Val His Lys Ala Ser Lys

340 345 350

Lys Lys Arg Glu Lys Ser Ser Ala Lys Lys Glu Arg Lys Ala Thr Lys

355 360 365

Thr Leu Ala He Val Leu Gly Val Phe Leu Phe Cys Trp Leu Pro Phe

370 375 380

Phe Ser Cys Asn He Met Asp Ala Met Cys Ala Lys Phe Lys Lys Asp 385 390 395 400

Cys Arg Pro Gly Leu Thr Ala Tyr Met Met Thr Thr Trp Leu Gly Tyr

405 410 415

He Asn Ser Phe Val Asn Pro Val He Tyr Thr He Phe Asn Pro Glu

420 425 430

Phe Arg Lys Ala Phe Lys Lys He Met His Met Gly 435 440

<210> 133 <211> 2970 <212> DNA <213> Drosophila

<400> 133 tccatgccag gcctggatgc acatgggccg gatggggatc aggtatatat cgagagcgtc 60 gagagttcgg tttgcgtttt gcccaccaag acgaaaccca aaaaggtcgc cttttacggc 120 agcaatggtc agcgctacac tttcctgttc aagggcatgg aggatctcca tctggacgaa 180 cgcatcatgc agttcctgtc catctcgaat gccattatgg cctgccgcag cgacgcaccc 240 ggcaatggct gctatcgtgc ccaccactat tcggttatac cattgggacc gcaatccgga 300 ctgattagct gggtggacgg ggtcacacca gtctttgcgc tctacaagaa gtggcaacag 360 agacggtccc aagttgctgg gaatgcggga gcaggtgctg tggcaaatgt cccgcgacgt 420 ttcacagact tgttctacaa caaactctcg cccctgttgg ccaagcacaa tatgcaggtg 480 agcgatccac gacgccaatg gccaatatcc gtcctgctcc aggtgctcga cgaattgtca 540 caggaaacac ccaatgatct gcttgcccgc gaactgtggt gccaggcggg aaatgccgcc 600 gagtggcggc aatcggtgcg tcgctttgtc cgctgcatgt cggtcatgtc gatgattggc 660 tatgtcattg gcctgggcga tcgtcatttg gacaacgtgc ttatcaacct gggaagcggc 720 gacatcgtgc atatcgacta caacgtgtgc ttcgagaagg gccgcaccct gcgcatcccc 780 gagaaggtgc ccttccgtct tacccagaat ctagtgcagg ccatgggcat cacaggaatc 840 gaggtaagac tattgctcat cctataccaa tcaattatct caacaaatcg ctgctggggg 900 tgtttaagaa acggtgctcc taaagataat gtccactttt attgctatat ctccatttaa 960 ttctaccaag ttaaagcgtt gggtttccca attccgttga tcactgagtg gccttcggtt 1020 tgatctcctg agatgaggat gtggcctcca tgcggtgctt gctgtccgcc ggcaattgat 1080 cctcgcactg cctcgccgtt cggcagcata atgtttggac aaaggctcgc cgaaagccag 1140 agttcttcca cgagtagata atcggattga gagcagagtt ggcaatggcc agagagaacg 1200 tcgtcttgta gatcatcgag ctgctctggc agatgctaaa tagctgggca atggccacac 1260 agaagtacgg tagccaacag agcgtgaagc agcccatgat gaagaccaca atctggacgc 1320 tcttccagtc tggatggagc agcagatttc gcatggtggt ggcctcgtcc gtgttgtaga 1380 ccaccgactg tcgcaatcgc agcgcctgct tggatgcctc gcgcatgatg cgccagtaga 1440 cgaggaacat acagatccag atgatcacaa aacccggcgt tatcactccg gcaatgtaac 1500 caggcgcgag aacttcgtcg aattcgcacg cctgtgcatc cggccatcga ttccagaaca 1560 ctggcagcag agccaccaat gcacccaagc accaattgaa tatgatgatg ctatatgcca 1620 ctcgacgggt catgtatcta cggtttcaaa gggtttcaca tatgtagcca ttgaattagg 1680 atttatcgcg ttcgcttaat accttacctt ctatagtgca gagcatagac gactgctata 1740 taccgatcca ccgcaatcga gatcagagtc aacatggaca cgcagcaggc gcagatgagc 1800 aggaagaagc gcagcaggca gggacctctc atggcgccaa tgtccgagcc catgtaaaat 1860 accagatgat agggcagtgc cagtcccaca cagaagtcgg agacggccag cgacaggatg 1920 aacagattgg agatgaccga tcgcaggtgg cggcaggtgc gcaccgccac aatggtcaga 1980 atattgccgc ccaggataag gacaaacaag aaggcattga tggctagcca cagcagatgg 2040

175 ccggcaccga aactggtcgc ctggagggtt atttccgttg gcgtttccgt ggcgttctgg 2100 tgctgccaca ggaacgggac gacacccaac gcttccgggg agcttcgata atcccaagcg 2160 ggcgatgagc tgctggtaaa tgccatgagc cacgatggta aacgaagcgc acgcgacgcc 2220 agtggttggc tatctggcaa ccgtgggagc tggagttgtg ctgacttttg gccaggactt 2280 cggctcggct cggatcggat tcagattcaa ttgggtttcg gctcggaccg tgggcgtcgt 2340 ttgtttacgt ttcgctggtg gctttacgac atcgtcatcg cgccagttaa ctgatagcgc 2400 gcccagatcc accgtgagaa ctgcaatccg ttgataagcc ctccactttg gcccaaccac 2460 cattcaccac cctcatacct aaccactcac ccacccatcg agtcaatcca accactccaa 2520 ccagccaaac tatccattgc ccccgagtat ttcgagtgtc cggactcccg ggcccaatgc 2580 atggccaaac agatcgctgg gggttttagc agattagccc agctccgcgg accaaaatag 2640 attgataaaa ggccagggcc agcaactggg atacgtggta aacagataca tcattgatat 2700 tcccaaattt cctcgataca ttgcaagcga agaaactata tgtaaatagt gatatcatca 2760 taattgttat aaatccgaga ccaacagtac aaccagtact attaggattg acatggttat 2820 ccactcttgg ttcttttaga attagaaatc aggagaatat atagtatata taggtacaac 2880 tctctgatct aatcccatat ttgaattatc tttaagatga gatattaaag atttcatgga 2940 tcagaacaga ccaggagttt gctaaggatg 2970

<210> 134 <211> 1116 <212> DNA <213> Drosophila

<400> 134 atggcattta ccagcagctc atcgcccgct tgggattatc gaagctcccc ggaagcgttg 60 ggtgtcgtcc cgttcctgtg gcagcaccag aacgccacgg aaacgccaac ggaaataacc 120 ctccaggcga ccagtttcgg tgccggccat ctgctgtggc tagccatcaa tgccttcttg 180 tttgtcctta tcctgggcgg caatattctg accattgtgg cggtgcgcac ctgccgccac 240 ctgcgatcgg tcatctccaa tctgttcatc ctgtcgctgg ccgtctccga cttctgtgtg 300 ggactggcac tgccctatca tctggtattt tacatgggct cggacattgg cgccatgaga 360 ggtccctgcc tgctgcgctt cttcctgctc atctgcgcct gctgcgtgtc catgttgact 420 ctgatctcga ttgcggtgga tcggtatata gcagtcgtct atgctctgca ctatagaaga 480 tacatgaccc gtcgagtggc atatagcatc atcatattca attggtgctt gggtgcattg 540 gtggctctgc tgccagtgtt ctggaatcga tggccggatg cacaggcgtg cgaattcgac 600 gaagttctcg cgcctggtta cattgccgga gtgataacgc cgggttttgt gatcatctgg 660 atctgtatgt tcctcgtcta ctggcgcatc atgcgcgagg catccaagca ggcgctgcga 720 ttgcgacagt cggtggtcta caacacggac gaggccacca ccatgcgaaa tctgctgctc 780 catccagact ggaagagcgt ccagattgtg gtcttcatca tgggctgctt cacgctctgt 840 tggctaccgt acttctgtgt ggccattgcc cagctattta gcatctgcca gagcagctcg 900 atgatctaca agacgacgtt ctctctggcc attgccaact ctgctctcaa tccgattatc 960 tactcgtgga agaactctgg ctttcggcga gcctttgtcc aaacattatg ctgccgaacg 1020 gcgaggcagt gcgaggatca attgccggcg gacagcaagc accgcatgga ggccacatcc 1080 tcatctcagg agatcaaacc gaaggccact cagtga 1116

<210> 135 <211> 371 <212> PRT <213> Drosophila

<400> 135

Met Ala Phe Thr Ser Ser Ser Ser Pro Ala Trp Asp Tyr Arg Ser Ser

1 5 10 15

Pro Glu Ala Leu Gly Val Val Pro Phe Leu Trp Gin His Gin Asn Ala

20 25 30

Thr Glu Thr Pro Thr Glu He Thr Leu Gin Ala Thr Ser Phe Gly Ala

35 40 45

Gly His Leu Leu Trp Leu Ala He Asn Ala Phe Leu Phe Val Leu He

50 55 60

Leu Gly Gly Asn He Leu Thr He Val Ala Val Arg Thr Cys Arg His 65 70 75 80

Leu Arg Ser Val He Ser Asn Leu Phe He Leu Ser Leu Ala Val Ser

176 85 90 95

Asp Phe Cys Val Gly Leu Ala Leu Pro Tyr His Leu Val Phe Tyr Met

100 105 110

Gly Ser Asp He Gly Ala Met Arg Gly Pro Cys Leu Leu Arg Phe Phe

115 120 125

Leu Leu He Cys Ala Cys Cys Val Ser Met Leu Thr Leu He Ser He

130 135 140

Ala Val Asp Arg Tyr He Ala Val Val Tyr Ala Leu His Tyr Arg Arg 145 150 155 160

Tyr Met Thr Arg Arg Val Ala Tyr Ser He He He Phe Asn Trp Cys

165 170 175

Leu Gly Ala Leu Val Ala Leu Leu Pro Val Phe Trp Asn Arg Trp Pro

180 185 190

Asp Ala Gin Ala Cys Glu Phe Asp Glu Val Leu Ala Pro Gly Tyr He

195 200 205

Ala Gly Val He Thr Pro Gly Phe Val He He Trp He Cys Met Phe

210 215 220

Leu Val Tyr Trp Arg He Met Arg Glu Ala Ser Lys Gin Ala Leu Arg 225 230 235 240

Leu Arg Gin Ser Val Val Tyr Asn Thr Asp Glu Ala Thr Thr Met Arg

245 250 255

Asn Leu Leu Leu His Pro Asp Trp Lys Ser Val Gin He Val Val Phe

260 265 270

He Met Gly Cys Phe Thr Leu Cys Trp Leu Pro Tyr Phe Cys Val Ala

275 280 285

He Ala Gin Leu Phe Ser He Cys Gin Ser Ser Ser Met He Tyr Lys

290 295 300

Thr Thr Phe Ser Leu Ala He Ala Asn Ser Ala Leu Asn Pro He He 305 310 315 320

Tyr Ser Trp Lys Asn Ser Gly Phe Arg Arg Ala Phe Val Gin Thr Leu

325 330 335

Cys Cys Arg Thr Ala Arg Gin Cys Glu Asp Gin Leu Pro Ala Asp Ser

340 345 350

Lys His Arg Met Glu Ala Thr Ser Ser Ser Gin Glu He Lys Pro Lys

355 360 365

Ala Thr Gin 370

<210> 136 <211> 7659 <212> DNA <213> Drosophila

<400> 136 gcctaaacga taagattaga aaatggaaat ggaaatgaag acagccacct gacgcaatct 60 cacatgccag aaatttgtcg tttgccatcc aaggccccga tttccgaaat cgaaaatcct 120 tgatatccaa ctggacatga ccagtttccg gaggaatgca ctccagttac acaactggca 180 caaacatttg tttgctgttt tctgaccaaa aacaagccac acttatgctg gcactttttt 240 gttgacagaa atatgcaagc agacacaagt aaatatttat ttgattattt attttaaaga 300 aatgtgcaag ctcaccgaat aaatattata ttttaaaatc aataagtaga aacctaaaca 360 aatacaagct ggtgaagcga ttgctctgca aattccacat atttaaacta ttaatttaca 420 aaaataaatg tggcggtcaa tttccagctg aacagttctc aacaattaat gaaaataatt 480 gccactgata ataatagttt tttttattat tcgattacat actttaaata tttttttagt 540 ttcccaatta gaaaactttt ttttaacaaa atatttaata ttccgtaaca gtatttatgc 600 ttaattacca gatgacagtt tttatttctt ttgactatac ttacattatt ttgaaaaaat 660 agcaattatt tttagacttc tgccacgaat gcctttaatt aatagctgat gcaatcgctt 720 aaactcaatt aagttacaca cgcaacccac atcttctgtg taaaaaaaaa tcaatgtatt 780 cgaccataaa taattccgct gcaatcagtg caacagtatt cagtcctgga actttaatag 840 cgccaagctg ttggaaaacc aattaaattc cctttcaaat ggagcgtaaa acgcaaaata 900

177 cttacgtatg atgggggcgc cacacactcg cacacgcatt tatgagctcg gcaaaaccca 960 tttgattgac taacgaaact tatttgccac tttatttcag cggacgcagt gcagcagttc 1020 cacgacgacc atgagcgacc agattggcaa ccccaatgca acattcagtg gcagtggcag 1080 tggcagtggc accaacgtcg cctccatcgc cgaaagtgtg gcggagagcg gaccggactt 1140 cgatgcactt cgggccgcct gcgaaacgcg gctaaatgcc agcggtcaac tggcgggtga 1200 gtcgtgcact gcgagaaaat atatcacaca gcacataact attaaagttt atgcagttat 1260 tttatttgat gcagttgtaa aacgctcacc agtaaatttc atttaaattt tagatgtttt 1320 tataaacata aatcaaaata aatttttttg cactgtttta cttacattcc ctttctttat 1380 gccagttatt tgtctttact taagcgaaag aaaaaattca ctctgaaatt gtagcactag 1440 ggaaatataa cagtttttgg tatttcacta catatttttg cccgtgcttc tggctctggc 1500 caactgcaat ttcggcgtcc attatgcacg agtaacttta aattgctgac ctaaccactc 1560 ccctttcctt ttggcccctt ggcaaacagg ctccggagga ccaggcgcag aagcaggaac 1620 ccactgtgcc ggcacctttg atggctggct ttgttggccg gatacggctg tcggcacttc 1680 cgcctacgaa ctctgcccgg acttcatcac gggattcgat ccagcaagta agtgcgccgg 1740 ggcaggagct gaattgttta ttaaattcca caaagctaca tccgtttcgg ggtcagctgg 1800 ggatctgcat atgacacgaa aaaatatata tatatacata catatatcac atgtatgtat 1860 gttacatata ggttaaatag catgccaaag ggaaatgtgt ttgcacgagg caatgcggtt 1920 ggataagttg gttgggttgt ttggtaggtg gagtgtgcca gtctaccctc taattgggct 1980 catccccgag ctcatcgtta tatacacata aatggaacag aaaatacgct ccaagccagg 2040 ccaaatcaat tggaaacttg ttatgtttat gctttgattt cgtgtcgtat ggaaacatca 2100 agtattcaca aaaccacacg ggctaaaggc aaagctcctt ggagctccct gggccactaa 2160 attatccaaa agagctcgac aaaatgctaa aatgtttcgc ctgatttggc acaatttgcc 2220 agagtctaac cgaaatcaaa tgtaaggcag aaaacacggc caaattgatt gaggctgctg 2280 ggcagagtag aagtcaaata tgtgtgtggg tatttaaaga tgctggagca cgaagaaagg 2340 ggatttaaat tttatcatgt ttgtgaattt catatttttt taatcattaa tcagtgttct 2400 tggcaaggtg ttgatgacgg tcataataac ataactgaag aagaaaaccc tttgaatagt 2460 ttcaccaact cattgtcgta tcattaacat atcataaata aaaatatcaa aggtgacttg 2520 aattatttct caactttctg ccacactgcg tgtatttcat tcaattataa atatatatat 2580 atataaatat aaatataaat taatcaactg attggccaaa cgcacaaaga aaactaatta 2640 attatgcttg gcattaaagc aaacgtttaa aaacaaagcg cacgctctag aaaatcgtca 2700 taaatgtgga taaatatttg aaccaattta tggcataaat catgcgctgc atgataattt 2760 gcattaatgg tatacaatat gtagccagcc aacttaaacc tcaacctcgt tttggccatg 2820 accagggcaa cgaaaatagc gagagttgaa tgactttttt tgttatgaca gagcggagaa 2880 aaacaaggcg agcgtcaaga aagtgctact tttgctacat ttagcttgtg gttagcatgg 2940 cgccaccccc tttttcatcc tttttgcatt tttttttttg ccttacgggg tcgccgccag 3000 cttgtacaag attatgtgct ttggcactgc gccgccatta acttttatgg cacttccggt 3060 cgccggatgt cgatgtggtg agctgtggtc gagaactccc tcaccccccg gctacttatc 3120 tgccacacag cgcgtatacg tgattttctc ggtctgcgtg ccaaacggcg ataaatggat 3180 tcttggccaa agatcatcgg tcgaaaaaaa aaagaaaacg gaagagccgg aaaaacgaac 3240 gacctgataa aactcacctt cgaagttcct aacaaaaatt ctccagtaat ttttctacaa 3300 gtgccactcg gtaaattgca ttgcaaactt ggtaatctac aatcgaatcg aatggaaagt 3360 ttttgtcacg aacttcgaat tgattcgact taaacacaca catgacccaa acaacagaat 3420 gattatgcaa ttttcaaatt gatatgcttg caattcgaat gcgaaccgca attcttttgc 3480 ggttaacttg gtggcagatg caataaataa tggttaattc aattgaatgc tcgggccgac 3540 cgcaaaatgt aaatatgagc cggaatattt atgcagtagt caatcatgaa atcacacata 3600 tttagcaagt gtaaatattt gtgtggtgca caggatgtga aaatgtttgc tagaaaaaac 3660 ggtaaagaat taatcgtata tacaatattt attgaggagc tgtaataagc agagtaaaca 3720 gcatggttaa ttatttttta tttatcgcaa actgacattg ctttaattat gcaggatatg 3780 cccacaagga atgcggtctc gatggcgagt ggttcaagca tccgctgacc aataaaacat 3840 ggtccaacta cacaacctgc gtaaatctcg aagacctcaa cgtaagccga tcccatacat 3900 aaatatccta tatatccttt atgtaattaa ttaatcgcaa cactatatat ccagtggagg 3960 cacacagtga atctgatctc cgaggttggc tacggcacct cactgctggc cattctgctg 4020 tcgttggcca tattgggtta tttcaagtga gtatggccaa gggctttgca ctccttcatc 4080 ttggccacaa gttgacagct tcgttgggag atggcaaaaa cacttagggg taatgaggca 4140 cgctggtgac ttatattgcg acttatatta tgacgactgg cgccataagt gaaatttact 4200 gatggcaaac aaatgcgaca gtggcttaat caactgccaa cctggatgct ggatgcccaa 4260 atgctcattg cactcattgc tcatttaatg cggcacaatt gacgccggaa atgggaaaat 4320 acattgtgtc cccatctcct ggtgactcga agcaggatat cgattaattt cccagtgcct 4380 gcagaccaat tagtgctctg ggtttgttta tcgcacattc gaatggaact ggggctcaag 4440 gataaaggat aatggatgtg cggactgagg ggcgagatcc catagacggt tcggccaact 4500

178 gacagaactg ttttaaattg tgtgccaaag gcaaataaaa tgggtccaga tacgtgtggg 4560 aatttggtct gccctaaaaa agtgaataat taaaagttta atgacagagc aatgggcaac 4620 accagccccg gaaaaacgca ttcctcaaac agctgtaatg aaaataccag agttttcatt 4680 caaataaaat ataagagtat aaaggaaatt gagtcgttgt gagcggccaa aaataaataa 4740 agaagtatta ttataaaata taccatcagt atattctcag tcaataattg tattgcttaa 4800 agaaagttta gaagtgaaaa gtagtatata aaataattta tttagacaga agtaaattaa 4860 gtaaagtaga gaagggatta acgaaaacaa tctaacctat tgaattaaat tgctgaaaag 4920 aaatcaaact agattcagtt tggccagatg tcagcaatca atgcaattga gcaaaggaga 4980 aacggaaaat gggaaaatgg acaaatgaac tttgtccttt tggtcgcagg actttttctg 5040 cctctttcgg ccctatccaa gctgcctcac atgcccctgg ccccgaatgc aaatgaagcc 5100 atagacaaac ttgcaaattt ggccataaaa acttgccaca aattgccggc caaagtaatt 5160 cgattcgcat atttgtcttt cgattgaaca gatccctgaa gtgcgcccgc atcacgctgc 5220 acatgaatct gttcgcctcg ttcgctgcca ataactcgtt gtggctggtc tggtacctgc 5280 tggtcatgcc gaattcggag ctactgcatc agagtccggt aagtgtgcac acctggcgaa 5340 tgcgtaatgg tgaatcaacc tcggcttccg atttccatat tccatactcc gtgcgaacac 5400 ccagatgcgc tgcgttgccc tgcacataac gctacactac ttcctcctgt ccaattactc 5460 ctggatgctc tgcgagggat tctatctgca caccgtcctc gtcgccgcat tcatttccga 5520 gaagaggctg gtcaaatggc tcatcgcatt cggctggggc tccccggcca tcgtcatatt 5580 cgtctatagc atggctcgcg gtctgggcgg cacgcccgag gacaatcgtc agtaagtgaa 5640 taatgaatgg gtacagctta caccgaaaga aaatgaggaa tgccaatagt tatcaaaagt 5700 gaccgacaac agacaaggtg taaccatatt gtgttgtcta gaagtatcct agtttaatga 5760 aatcccacag acttgagtat cacagattga tatcaagata tttctgtgta gctaagatat 5820 tcagtctgtc gagctcttga ccaaatgcta atcaaatcaa tcagcaattc acccactgac 5880 tcatctcgca ttccttcgcc aacttgcagc tgctggatga accaaaccaa ctaccaaaac 5940 attcttatgg tgcctgtgtg tatctccatg ttcctgaacc tcctgttcct gtgcaacatt 6000 gtgcgagtgg tccttttgaa actgaatgcc ccggccagta ttcagggcag ctgcggtcca 6060 tcgcgaacgg ttttgcaagc atttcggtaa gttttcccgt ccaaaacaaa agaaaaaaaa 6120 aagaactgtt gggggggaga ttgaaacact tataagcgaa gcagagaact ctcaactggc 6180 ccacggggcg aatgcgtaat tatattttgt ttcccttgta tttagactct ttcccatcgg 6240 ccatcaggtc ttttattgtt tattcgctct gcactctgga agttgggctc attttacatt 6300 ttgaattacg catacgccgc gttgacttgc atgttaatac acagctgaaa aacgaaaaca 6360 aggcattata attcaccctc tcatcctgtt ttagggcaac gctgcttttg gttcctctgc 6420 tcggcctcca gtacatcctt acgccctttc gtcctgcacc caaacatccc tgggagaata 6480 catacgaaat catctcggcg tttacggcct catttcaagt aagtaaaatg ttttcgtttc 6540 gtttctgttc tcgtttcgtt tttttttcgt tttttttttt tgcttttttc tttccggctt 6600 ttgttttgca cgctctcata aaatcacttt acgactccga gctggctaaa aagttatgat 6660 gttagttcgc ctcatggtgc catccaccac tgggaatgca aataagccag cattactgga 6720 ataccgaata ccaaatacca ggactagcag ctcattagat cggggctctt ttcaaatcaa 6780 taatgaaaat acacgccatg tgaaataccc accattggca tttcacttga tctcagttta 6840 ttaaattgct ggccgagatt ggagcgaagt tcccccgttg gaaaaatgta gcaagttgag 6900 catgaaatgc actctcgcac acaggaactc gtaaaagcaa ctcgagcttg tccctcggcc 6960 aactcagtct cgatagacca gcatttacac atggttaaca cacatacata tatttcttgg 7020 ccgcaactta aagacaacga cggcaaactt catccagcta cgttgccttc ttgtttgttg 7080 aatacccaaa gaatctttca gttcatgttt gcagtacaca gataaaataa tttgcatata 7140 ttttcgtgtt tttgtgcacg aaatggtttt tcattacaga ctgttgatat aacagttgcc 7200 atggaggtag aggtgcctaa aagtatgttg cagcttagat ggctttcctt tacaaaattt 7260 caaaagtaat ttctaaggca ccccctagct gttattcgaa aatcttttag ttcgatctaa 7320 aacccaactc aatcggttca aaaaggtagc ccattgaatt cataaacagc cctaaaacaa 7380 caggaaaatc cattatcttg cgagtagaca taaaatcatc ttgggtgcca ctaagctgca 7440 gttgagctct tgactatttt ctataacttg gcaaactgaa cattgtcacc tcggtctgag 7500 ccttttttca tcattgccaa tcgataggtg aaatctttta ttcgactgct aaaagtttaa 7560 agccagtcga cgggtacttt tcctttgcat tttcctcttg tcgtatttat tcactttttt 7620 ttatgtcgct gttttccgtt ggcttatttg ctgcaaaga 7659

<210> 137 <211> 1365 <212> DNA <213> Drosophila

179 <400> 137 cggacgcagt gcagcagttc cacgacgacc atgagcgacc agattggcaa ccccaatgca 60 acattcagtg gcagtggcag tggcagtggc accaacgtcg cctccatcgc cgaaagtgtg 120 gcggagagcg gaccggactt cgatgcactt cgggccgcct gcgaaacgcg gctaaatgcc 180 agcggtcaac tggcgggctc cggaggacca ggcgcagaag caggaaccca ctgtgccggc 240 acctttgatg gctggctttg ttggccggat acggctgtcg gcacttccgc ctacgaactc 300 tgcccggact tcatcacggg attcgatcca gcaagatatg cccacaagga atgcggtctc 360 gatggcgagt ggttcaagca tccgctgacc aataaaacat ggtccaacta cacaacctgc 420 gtaaatctcg aagacctcaa ctggaggcac acagtgaatc tgatctccga ggttggctac 480 ggcacctcac tgctggccat tctgctgtcg ttggccatat tgggttattt caataattcg 540 attcgcatat ttgtctttcg attgaacaga tccctgaagt gcgcccgcat cacgctgcac 600 atgaatctgt tcgcctcgtt cgctgccaat aactcgttgt ggctggtctg gtacctgctg 660 gtcatgccga attcggagct actgcatcag agtccgatgc gctgcgttgc cctgcacata 720 acgctacact acttcctcct gtccaattac tcctggatgc tctgcgaggg attctatctg 780 cacaccgtcc tcgtcgccgc attcatttcc gagaagaggc tggtcaaatg gctcatcgca 840 ttcggctggg gctccccggc catcgtcata ttcgtctata gcatggctcg cggtctgggc 900 ggcacgcccg aggacaatcg tcactgctgg atgaaccaaa ccaactacca aaacattctt 960 atggtgcctg tgtgtatctc catgttcctg aacctcctgt tcctgtgcaa cattgtgcga 1020 gtggtccttt tgaaactgaa tgccccggcc agtattcagg gcagctgcgg tccatcgcga 1080 acggttttgc aagcatttcg ggcaacgctg cttttggttc ctctgctcgg cctccagtac 1140 atccttacgc cctttcgtcc tgcacccaaa catccctggg agaatacata cgaaatcatc 1200 tcggcgttta cggcctcatt tcaagtaagt aaaatgtttt cgtttcgttt ctgttctcgt 1260 ttcgtttttt tttcgttttt tttttttgct tttttctttc cggcttttgt tttgcacgct 1320 ctcataaaat cactttacga ctccgagctg gctaaaaagt tatga 1365

<210> 138 <211> 444 <212> PRT <213> Drosophila

<400> 138

Met Ser Asp Gin He Gly Asn Pro Asn Ala Thr Phe Ser Gly Ser Gly

1 5 10 15

Ser Gly Ser Gly Thr Asn Val Ala Ser He Ala Glu Ser Val Ala Glu

20 25 30

Ser Gly Pro Asp Phe Asp Ala Leu Arg Ala Ala Cys Glu Thr Arg Leu

35 40 45

Asn Ala Ser Gly Gin Leu Ala Gly Ser Gly Gly Pro Gly Ala Glu Ala

50 55 60

Gly Thr His Cys Ala Gly Thr Phe Asp Gly Trp Leu Cys Trp Pro Asp 65 70 75 80

Thr Ala Val Gly Thr Ser Ala Tyr Glu Leu Cys Pro Asp Phe He Thr

85 90 95

Gly Phe Asp Pro Ala Arg Tyr Ala His Lys Glu Cys Gly Leu Asp Gly

100 105 110

Glu Trp Phe Lys His Pro Leu Thr Asn Lys Thr Trp Ser Asn Tyr Thr

115 120 125

Thr Cys Val Asn Leu Glu Asp Leu Asn Trp Arg His Thr Val Asn Leu

130 135 140

He Ser Glu Val Gly Tyr Gly Thr Ser Leu Leu Ala He Leu Leu Ser 145 150 155 160

Leu Ala He Leu Gly Tyr Phe Asn Asn Ser He Arg He Phe Val Phe

165 170 175

Arg Leu Asn Arg Ser Leu Lys Cys Ala Arg He Thr Leu His Met Asn

180 185 190

Leu Phe Ala Ser Phe Ala Ala Asn Asn Ser Leu Trp Leu Val Trp Tyr

195 200 205

Leu Leu Val Met Pro Asn Ser Glu Leu Leu His Gin Ser Pro Met Arg

210 215 220

180 Cys Val Ala Leu His He Thr Leu His Tyr Phe Leu Leu Ser Asn Tyr 225 230 235 240

Ser Trp Met Leu Cys Glu Gly Phe Tyr Leu His Thr Val Leu Val Ala

245 250 255

Ala Phe He Ser Glu Lys Arg Leu Val Lys Trp Leu He Ala Phe Gly

260 265 270

Trp Gly Ser Pro Ala He Val He Phe Val Tyr Ser Met Ala Arg Gly

275 280 285

Leu Gly Gly Thr Pro Glu Asp Asn Arg His Cys Trp Met Asn Gin Thr

290 295 300

Asn Tyr Gin Asn He Leu Met Val Pro Val Cys He Ser Met Phe Leu 305 310 315 320

Asn Leu Leu Phe Leu Cys Asn He Val Arg Val Val Leu Leu Lys Leu

325 330 335

Asn Ala Pro Ala Ser He Gin Gly Ser Cys Gly Pro Ser Arg Thr Val

340 345 350

Leu Gin Ala Phe Arg Ala Thr Leu Leu Leu Val Pro Leu Leu Gly Leu

355 360 365

Gin Tyr He Leu Thr Pro Phe Arg Pro Ala Pro Lys His Pro Trp Glu

370 375 380

Asn Thr Tyr Glu He He Ser Ala Phe Thr Ala Ser Phe Gin Val Ser 385 390 395 400

Lys Met Phe Ser Phe Arg Phe Cys Ser Arg Phe Val Phe Phe Ser Phe

405 410 415

Phe Phe Phe Ala Phe Phe Phe Pro Ala Phe Val Leu His Ala Leu He

420 425 430

Lys Ser Leu Tyr Asp Ser Glu Leu Ala Lys Lys Leu 435 440

<210> 139 <211> 4185 <212> DNA <213> Drosophila

<400> 139 attcgttcgg tattttcgca tttggcatgt ttgtggctaa gatatcatca attcaacaca 60 atgatcaaca atattcaacg acaaacactc gacttgggac cctggatgct tcatcggcgg 120 cgctcgggaa actgaatttg acccactaag ggaactaggc aaaattgcaa cgctctgttg 180 gtaagcccac caaatcgaag cgttcagggg cggccaaaag gaaaatgaat cattctaccg 240 atttgaacaa cgatcgaaac ttcacactag cctatcattt cagtatcata gttgtatgtt 300 gtatggctaa gaactactgg aaatgtcttt ttgggcttat ttgctttttg gattttaaca 360 tatttgctgt gttttatatt cgtttagtgg gccttggttt ttcgtttctt aagcgcaatt 420 cgcaaagcgt gcgaagattg aagattttcc gaattttgaa ttctcatatt tcggcccgtc 480 gtcaagtttg gcaaattgtt taataaacgc tacacgattt cattttgtaa aattctaaat 540 gctacttaat atggactttg aaaaaggttt atacttatgc aatctttaga taataatcct 600 gctgctcgag tagcatatga ttttcgtata ttgtttttgt tgtagcaagt tcgaattgta 660 aaccggaaac ggaaatgttg ctcttgccta gtgaattgtc tcttgtctac gaattagaat 720 tagaattaga tcgctgctac atatgtatat gtatatggct agagttaagt acaagtatat 780 atatacgtgg taagctcata aatacacaat aataatcgtc aatcaattca atcaatcaat 840 cggtgaatca atcataattg gatacgctaa aaactcttag cttagcttag gtctagaaat 900 atgaatatgt ctttcaacgt gtctgtggtt ttggtgtttt tggtgtttct gtgtggtttg 960 ctgtatggtg gctgagtggt tgagtggttg cgtttttagt tttcagtttt tctgtggctg 1020 tgactgtggg gtggtgcttt cattggcatg tcgcgtagcg ccaaacggcc cgtaaatatg 1080 caactatatg gcaaacaggc aagtaagtgt ttatatatat tgagagagag agatatatag 1140 agagttaagg aaatggctca atgcaattac aaccaattat ttacttgcag gactttgtag 1200 ttcttctcaa agggattacg gaggatgggt ttgggagggg gatttttacg gataattatt 1260 gtattttttt ttgaggagaa tgaaaatcta aatctaactc tagtcatctg ggtccaaccc 1320 gattagctct gcttgcaaac ggcccttagt cttacaacaa atggttaagc aaaatactct 1380 caaagcgata cggaattgcg gcgacatact ggtcatgatc agaattttcc aaaacgaatt 1440

181 caatatgccg atccagacga cggcgaagtt gataagagta ctttggataa catcgcccgt 1500 gaccacctcg tacagacgca acagaatcca tggcagccag gacacccaga atgcaaagac 1560 taatgcgaat gacatcatat gactagggtt cgataaattt tcagccagag cagttgcata 1620 ttctttatcg tgtatcggct cgccggacct aatcttacgc atcattacaa agatatagcc 1680 gtagttgtgt acgattgaaa tgaggctggg acctaagact aatatcgcca aggtggcgct 1740 atatgctgcc atattccccc agtccagcat gcaaatgtgc gtcatgttgt tctcgatggg 1800 catcgagtag cccaggattg ggggacagca cagcagggcc gccgatatcc aagtgaacac 1860 catccagcat tggcatctgc acgataaagg tcacaagaga tcaaagatta atccagtttt 1920 aatccagatg aggaggaatt cggggttcca ttggcgctac tcacctcgtt ttcgtctgca 1980 ccgtttcata tctgagtggc ttccgcaccg caagatagcg atccactgat atccacatga 2040 aggtgtatac cgataccgcc cacagagtga cctccagata gccggtgaag cgacacacga 2100 tgtcgccgta catccattct ccggtcaaag cgggatacac ggagaagggc accaccagga 2160 gtccgcagag cagatcggcg atggccaggg acaagaggta gtagttgatc acctctgtgg 2220 gtcctgcgat gacagcaata tcgttagaaa acgaagtaga ggtgtattca aaaataatag 2280 gcaaatgcaa acaataatat ttaaatggat cattcaataa tttgggcgag tctatttgta 2340 cgacattcac tagaactatt tagaaaccta aggttcttaa atttatccaa taacaatcaa 2400 tttataggat aaaagtttag gtacaaaaag gggaaagaaa taatatgctt aagcacaatt 2460 ggtttttgaa ttttttcaaa gcaattaaga caacaagaaa acaacacatt tgaatttttg 2520 gggaggatgc cgtgttactt cattcctttc actttcacat caaaatcatg gatgcatttt 2580 aagtataaac attggactta agtggtcaaa ataaattata ttcaacacat atgtaggtta 2640 cttatgaaaa tattatgctt gaggccaaac ccaaccgcga gattcgagat gttcctgtgg 2700 aaagtgttat gtgagtgtga tattcgtgca acgtaccctt gaagttggca taggtggcga 2760 taatgaggag gttggacagg acgatggcca cgcccagtat cgatatgagc accgccttgg 2820 tgagggcctc caccttggaa ttatcctgta ggtagctcat ttcctgcatt tttacgggct 2880 ggcactgtcg gttgaaatgg gcgctcctgt gctcgttgta tacgctccct tagctccttg 2940 tccgtttccc tcctccttgg ctcctcctgc tttcacctgc tttcgctgct gctttcaccc 3000 gctttctccg caccttcttg gcgggctgat tgttatgcaa aggccagtgg acgtggacgt 3060 gaccgtactt tacttccggt catggcggac gcccatgcaa ttgtcctgtg ccttcggttg 3120 tgtgtgtcgg tgtgtctgtg agtgtctatg tgtgcttagg tgagtgtgtc gatgtgtgag 3180 tgtgtgtgtg tgtctgggtg cgagtgttgg tggcgtcctt tattgtgcaa cgaggcttgc 3240 acacgcgaag gtcgtcggag tccttggcgc tgttttttcg tcctttctcc aacgttggcg 3300 ccaaatttgt ataaattttc tactgcctac ttttatttgg gctgcaactt ctactactgc 3360 ccaccttttg gcgccgagcc aagcatttga ttgttaccct cacaatcctg gcgtcgtggt 3420 taaggttaag gataaggttg tgctggtgtg tgtgtgtcta tgtgtgtgtc tgaagctcgt 3480 ttaaaatgct gcttgggcta aaatcttaca cgtaaaatct agtaattgcg tacaatttgg 3540 tttctatctt agaggatcgt taatgattta aagaattcgt tttgttttgc taaattcaca 3600 acgctctttg ctaagtttta atgaacgtca aaactgttag ttgtatgctt gaataattcg 3660 ctactagttt taatatcgat ttaaaaatgt acacatttca aactcgcaag tggaagaata 3720 atgattatta atttaactat ttaatgtgta ataattacgc ggttttcagg gctctttttc 3780 tttcggggtt agttgaaata tctttcgact ataattaaag cacagcacaa atggttttgt 3840 tgttttgtaa ggcttctgtt gtgctacatt taagtttgtt aaaatagttc gataatagtt 3900 cggttgttaa gtatcggttt tgctatttaa tttcgctgct tggtgattgt gattatcctt 3960 ttgcttgtaa attctggctc ttgttgctgt tgttggtgtt taaactccac gtcctgctgt 4020 cgttttaagc taattgtgcg catctgaaag gacaaaggat agcaattgta tgcctttagc 4080 gcttcataaa tagtttacag aatcttccat cttgagccaa tcaataaatt atcccacata 4140 cggcagcagg cggaaaaagc cttttagctg cacaaacgct ttaca 4185

<210> 140 <211> 1584 <212> DNA <213> Drosophila

<400> 140 acacactcac acatcgacac actcacctaa gcacacatag acactcacag acacaccgac 60 acacacaacc gaaggcacag gacaattgca tgggcgtccg ccatgaccgg aagtaaagta 120 cggtcacgtc cacgtccact ggcctttgca taacaatcag cccgccaaga aggtgcggag 180 aaagcgggtg aaagcagcag cgaaagcagg tgaaagcagg aggagccaag gaggagggaa 240 acggacaagg agctaaggga gcgtatacaa cgagcacagg agcgcccatt tcaaccgaca 300 gtgccagccc gtaaaaatgc aggaaatgag ctacctacag gataattcca aggtggaggc 360 cctcaccaag gcggtgctca tatcgatact gggcgtggcc atcgtcctgt ccaacctcct 420

182 cattatcgcc acctatgcca acttcaaggg acccacagag gtgatcaact actacctctt 480 gtccctggcc atcgccgatc tgctctgcgg actcctggtg gtgcccttct ccgtgtatcc 540 cgctttgacc ggagaatgga tgtacggcga catcgtgtgt cgcttcaccg gctatctgga 600 ggtcactctg tgggcggtat cggtatacac cttcatgtgg atatcagtgg atcgctatct 660 tgcggtgcgg aagccactca gatatgaaac ggtgcagacg aaaacgagat gccaatgctg 720 gatggtgttc acttggatat cggcggccct gctgtgctgt cccccaatcc tgggctactc 780 gatgcccatc gagaacaaca tgacgcacat ttgcatgctg gactggggga atatggcagc 840 atatagcgcc accttggcga tattagtctt aggtcccagc ctcatttcaa tcgtacacaa 900 ctacggctat atctttgtaa tgatgcgtaa gattaggtcc ggcgagccga tacacgataa 960 agaatatgca actgctctgg ctgaaaattt atcgaaccct agtcatatga tgtcattcgc 1020 attagtcttt gcattctggg tgtcctggct gccatggatt ctgttgcgtc tgtacgaggt 1080 ggtcacgggc gatgttatcc aaagtactct tatcaacttc gccgtcgtct ggatcggcat 1140 attgaattcg ttttggaaaa ttctgatcat gaccagtatg tcgccgcaat tccgtatcgc 1200 tttgagagta ttttgcttaa ccatttgttg taagactaag ggccgtttgc aagcagagct 1260 aatcgggttg gacccagatg actagagtta gatttagatt ttcattctcc tcaaaaaaaa 1320 atacaataat tatccgtaaa aatccccctc ccaaacccat cctccgtaat ccctttgaga 1380 agaactacaa agtcctgcaa gtaaataatt ggttgtaatt gcattgagcc atttccttaa 1440 ctctctatat atctctctct ctcaatatat ataaacactt acttgcctgt ttgccatata 1500 gttgcatatt tacgggccgt ttggcgctac gcgacatgcc aatgaaagca ccaccccaca 1560 gtcacagcca cagaaaaact gaaa 1584

<210> 141

<211> 322

<212> PRT

<213> Drosophila

<400> 141 Met Gin Glu Met Ser Tyr Leu Gin Asp Asn Ser Lys Val Glu Ala Leu

1 5 10 15 Thr Lys Ala Val Leu He Ser He Leu Gly Val Ala He Val Leu Ser 20 25 30

Asn Leu Leu He He Ala Thr Tyr Ala Asn Phe Lys Gly Pro Thr Glu

35 40 45 Val He Asn Tyr Tyr Leu Leu Ser Leu Ala He Ala Asp Leu Leu Cys

50 55 60 Gly Leu Leu Val Val Pro Phe Ser Val Tyr Pro Ala Leu Thr Gly Glu 65 70 75 80 Trp Met Tyr Gly Asp He Val Cys Arg Phe Thr Gly Tyr Leu Glu Val

85 90 95

Thr Leu Trp Ala Val Ser Val Tyr Thr Phe Met Trp He Ser Val Asp 100 105 110

Arg Tyr Leu Ala Val Arg Lys Pro Leu Arg Tyr Glu Thr Val Gin Thr

115 120 125

Lys Thr Arg Cys Gin Cys Trp Met Val Phe Thr Trp He Ser Ala Ala

130 135 140 Leu Leu Cys Cys Pro Pro He Leu Gly Tyr Ser Met Pro He Glu Asn 145 150 155 160 Asn Met Thr His He Cys Met Leu Asp Trp Gly Asn Met Ala Ala Tyr

165 170 175

Ser Ala Thr Leu Ala He Leu Val Leu Gly Pro Ser Leu He Ser He 180 185 190

Val His Asn Tyr Gly Tyr He Phe Val Met Met Arg Lys He Arg Ser

195 200 205

Gly Glu Pro He His Asp Lys Glu Tyr Ala Thr Ala Leu Ala Glu Asn

210 215 220 Leu Ser Asn Pro Ser His Met Met Ser Phe Ala Leu Val Phe Ala Phe 225 230 235 240 Trp Val Ser Trp Leu Pro Trp He Leu Leu Arg Leu Tyr Glu Val Val

245 250 255

Thr Gly Asp Val He Gin Ser Thr Leu He Asn Phe Ala Val Val Trp

183 260 265 270

He Gly He Leu Asn Ser Phe Trp Lys He Leu He Met Thr Ser Met

275 280 285

Ser Pro Gin Phe Arg He Ala Leu Arg Val Phe Cys Leu Thr He Cys

290 295 300

Cys Lys Thr Lys Gly Arg Leu Gin Ala Glu Leu He Gly Leu Asp Pro 305 310 315 320

Asp Asp

<210> 142 <211> 4900 <212> DNA <213> Drosophila

<400> 142 taaatatgca tattgaacga ggcaatgcaa tgcgattgag gtccggctgt gcgtttcagt 60 tgcgaaatga gttgcgaaca ggatttatat tcagatttag ccattagcca aatgcaacac 120 cttcgacgac gtgtggacac gtcgactttg attcggccaa ctgagtgatc cggggtagta 180 gtgtcagatg ccaacattac ttatgcactg aaagaaataa ataaaggatt tacatgtgta 240 gtaatgtata attgggctgc atgacatgca tgataatgat caactttcaa gcaataataa 300 ttctatgaca tcacgacatt catacggaca gaaagacgaa catggattta ccattaaaat 360 gtaattataa tataatataa taaagtatct aaagaatttt ttacttggat ctcctagcaa 420 ttttaaccat attctcaaat gcaaaatgtg aagttcttgc aaatagatac acagactaat 480 gggtccgcat ttgccaatta attgcctaca acgcccaggt tgctttgaat cacaggtgga 540 catttggaca ggtttgctca gctcactggc agctccactt tggccattca aaattgttta 600 tcgctttgac gagttgcagt agcaatttcg acaccgtatg cccataatga agaaacggca 660 ttgataataa caaagtaatg ataaattaga tgctgttgac gtctaattca tttttgatga 720 tagtattgat tttatacata aatgacacaa tttccctttt attttgtaaa acattatggc 780 attttcactt taatggtcct gtaaaacaca agttagttgt aaagcacaga aaaactttcc 840 atttcgatga caagaagtcc tttaaaattc aaataaatat ataattctaa ttctaaataa 900 ataattctaa gcaatggttt atgtatttaa actccttaaa ttttgttcca gtttttaact 960 agcacatata catcaaaaga gcggaactag atagtctaca atgatgcaag agaccggcaa 1020 tcaaatggga cagacccata tgcaccagcg ggttcctttc aacgacacgg ttctgaagga 1080 ctatcatctc acgagcaccg atatcgagaa gtttgtaaag ctatggcagg agtaccagat 1140 gaagaacatg acccctcagg tggatgagtg ccagggctat tgccaggggg aaatatacaa 1200 ctggttgcga gcctacaaca gcatccatgg atacgtttcg ctgatggtaa gtaatactcg 1260 tgattacaac tccccctggg cacgaaaccc gcaatgttgg ccaaaacaaa ggaatcggtt 1320 gactaatgat gagcaaggga agccaagacg atacacacag accttcgccg acagaccact 1380 gatgaatgta ggggacttct ttacctttga actcttgcca aagtcgtcct tttttcgaat 1440 taaagttata gcatgcgctc agcttaacca tcaaaatcac aaatgaaatt agtggccggg 1500 aatctcggtc ttttgtttat gtccgggttt cccttttcag ggcttttttg aaaaggatat 1560 aaattatatt agatgtagtt aagccgttga ggcgttaatg tgcttttttc attataattt 1620 tcagtcgtaa gtcattttgc gttgtagcag acggccttta ccacaggaat tgggtcagaa 1680 aataccgaga atccatttcc atcaaggcta gttcatagcc catcttttca aataaatata 1740 caataaatca aatacagttg aaaaatgtaa ctttattgct ttccttcgtt cgcacaaaaa 1800 atagtttacc tcttaaattg aaataaaatt ctgaaccaaa cttcggttac tgtagttcca 1860 tttttttttt tttttgcttg tgtgagcaat gttaagaaat gtaaatacga gaggtcacga 1920 cagttgagtt gctgctcacg agctgaataa ataaaatatt catccacttt ggtgtccaag 1980 gggagtgcat tcagttgaaa gtatgtgagc gctcacagtt tcgatttgac aaaggacgca 2040 ttttatgttg attctttctt gtttctttaa atcacctaga tttgcatttt cgggacaata 2100 gcaaacatct tgaacataat ggtcctgacc agaaaggaaa tggccaagac gcccataaat 2160 aatatactta agtggctggc ggtggccgat atgtttgtga tgctggaata tataccctat 2220 acatcgtatc agtatatata tatggggcca ggtaagcata catttagtaa taatatttaa 2280 taatagtctt ggttatagct ttacttgtta tttatttatt agtgttatca gctagattat 2340 tattataaag gtatactctt gatcaggatc tacacacgtc tgtctgtccg tttctaaggg 2400 tatattttgt taacaatttt gttaacaatt cccatatatc ctttcccctt tgcacttact 2460 tttagttgag taacgagtat gtggtagtcg aggcaatcgg ctatgacctt ctctgtaggt 2520 ttcctttctt ttttaatttt aagccgttta aatttttttg aattatttaa tattctttgt 2580

184 atggctgttg caggtgaaaa agatttgagc tacacctggg cggtttgtct gctggttcac 2640 atgcacttca cccagatcct gcatacgatt tccatcggat tgactgtcac gctggcggtg 2700 tggcggtatg tggctatcag gtgagatgat ccttcggcca gctatgcatg acttattccg 2760 gaattcgccg tcatccatgt agagtttgtc tccggttcac attcatgata atccacatcc 2820 gcaattcgaa cagacatccg gctaatctga ttaccacatc attgtggcaa tgtggcttct 2880 cttctcttcc cccgtctttt gtttatagcc aaatgttacc gtctctattc cacagacatc 2940 cgaacggggg ctgtgccaat ttcctgctag cacattcccg ggaggcgatc ctcctgccct 3000 tcatcctgtc gccgatcctc tgcctgccca cgtactttgt gttccaggtg cgtgagacgt 3060 acgacgtgga caaggtcaac tcggaggcca tgtatcatgt ttatttcgac aaggactcgg 3120 tgctctacag gtgcgcttag ataagaagtc tgatgtcatt tatgcatcct gcgaagaacc 3180 aattgtaaaa tatttcatcg tgaaaatcct taacagattc aacttctgga tacattccgt 3240 gctcatcaaa cttctgccgt gcggcatatt aattgtgatc agtgcagtac ttatgcacgt 3300 tttgtgcgag gcatcgagac gtcgcttgaa gctgagggat tacaacaatc ccgccaaata 3360 tgccatccag cttaatctga atgaaaccaa atccaagaag taagtacgca cttgactcgt 3420 ttagtgctta agaattcgcc tcatttgcag tttgccttgt tagtttcatg atctttgatt 3480 tttctgtttt tgaatggtct cggattttgt caaatctctt cttaggttcc tttttgccat 3540 cttttttata aatttgtctt tttgtttttg tatcttaggc cgcctcgctg tgatcgccgt 3600 aacgatcgga ctaccctttt gctggttgcg gtactggttt tgtttctgat cacggagttt 3660 ccgcagggat tacttggtct gctgtccgga gtgatggaga agtgcttctt cgcccactgc 3720 tatccgccgt ttggagagct gatggatctg ctggcactga tcaacgccgc cgtcggattc 3780 gtgctgtacg gtctgatgtc gaaacagttc cggaccacct tccgatcgct gttcatgaag 3840 cggcactttg gcagcaccga aatgaccaga ttgacccgcg taaccacgac ttgcgtctag 3900 ttgggcacat ctaaagatgt gatcatgggc aggagcaaac actagtgagg gatgaagtag 3960 gtgagggaca tccaagatgt tccggcccgg cattgaattt gaattttcta aagcataaac 4020 tttataaaag tttcgttgac taaacaaagc ctaaatatga gaaactgtga gtgtggaatt 4080 attgtacggg ctgaccagtt gatcagttga tttccacaat ggtttacttt taggtgtagt 4140 cctaaggcgt tgactggtgc atcgatcggt ttagaaattg attctgcttg tgatctggct 4200 gtttcgcaaa gtgccatttc atttccaaat aattacattg attagtttac cagttggtgt 4260 ttcaaattcg tattagtata taagtttcat aggctaagtc agctgtacaa agctgtacaa 4320 atacgagaca tttacttttc cataagatgc agaaaaaaaa acaggaatcc atcatcagca 4380 aaactgtagc catgctaaga ggactgaaga actcactgag ccccgagttg ctctctcttc 4440 ttagctggaa tcacgaaaga attctatttt gattgtatgg cgttaactgg ttttcaacaa 4500 agtgccaatg cattttaaat tggctaattg aataaccata ttttgagtac tttttaagtc 4560 gcttatacta tttataaata aatgtgaaca ctttcaaaaa aaatatgttt gatgtgagtt 4620 gcatacaaat gaaacgttta ttgctttcca ttaccgaaaa atgaacatct aattctgact 4680 gacaacagca ttcacctcca gtggcaattc gtccggcaga agttccgtgg cccgattgtg 4740 tcccaaatca gactcgccca tatccgcgga atccagcagg atgccattgc cctgattcga 4800 gatgcgcagc agggatttca gcttggtggc ttggaatttg tactgcagga taatgagatt 4860 gataaaatct gctctcgagg gagtttcgac cataatgtaa 4900

<210> 143 <211> 1245 <212> DNA <213> Drosophila

<400> 143 atgatgcaag agaccggcaa tcaaatggga cagacccata tgcaccagcg ggttcctttc 60 aacgacacgg ttctgaagga ctatcatctc acgagcaccg atatcgagaa gtttgtaaag 120 ctatggcagg agtaccagat gaagaacatg acccctcagg tggatgagtg ccagggctat 180 tgccaggggg aaatatacaa ctggttgcga gcctacaaca gcatccatgg atacgtttcg 240 ctgatgattt gcattttcgg gacaatagca aacatcttga acataatggt cctgaccaga 300 aaggaaatgg ccaagacgcc cataaataat atacttaagt ggctggcggt ggccgatatg 360 tttgtgatgc tggaatatat accctataca tcgtatcagt atatatatat ggggccaggt 420 gaaaaagatt tgagctacac ctgggcggtt tgtctgctgg ttcacatgca cttcacccag 480 atcctgcata cgatttccat cggattgact gtcacgctgg cggtgtggcg gtatgtggct 540 atcagacatc cgaacggggg ctgtgccaat ttcctgctag cacattcccg ggaggcgatc 600 ctcctgccct tcatcctgtc gccgatcctc tgcctgccca cgtactttgt gttccaggtg 660 cgtgagacgt acgacgtgga caaggtcaac tcggaggcca tgtatcatgt ttatttcgac 720 aaggactcgg tgctctacag attcaacttc tggatacatt ccgtgctcat caaacttctg 780 ccgtgcggca tattaattgt gatcagtgca gtacttatgc acgttttgtg cgaggcatcg 840

185 agacgtcgct tgaagctgag ggattacaac aatcccgcca aatatgccat ccagcttaat 900 ctgaatgaaa ccaaatccaa gaagccgcct cgctgtgatc gccgtaacga tcggactacc 960 cttttgctgg ttgcggtact ggttttgttt ctgatcacgg agtttccgca gggattactt 1020 ggtctgctgt ccggagtgat ggagaagtgc ttcttcgccc actgctatcc gccgtttgga 1080 gagctgatgg atctgctggc actgatcaac gccgccgtcg gattcgtgct gtacggtctg 1140 atgtcgaaac agttccggac caccttccga tcgctgttca tgaagcggca ctttggcagc 1200 accgaaatga ccagattgac ccgcgtaacc acgacttgcg tctag 1245

<210> 144 <211> 414 <212> PRT <213> Drosophila

<400> 144

Met Met Gin Glu Thr Gly Asn Gin Met Gly Gin Thr His Met His Gin

1 5 10 15

Arg Val Pro Phe Asn Asp Thr Val Leu Lys Asp Tyr His Leu Thr Ser

20 25 30

Thr Asp He Glu Lys Phe Val Lys Leu Trp Gin Glu Tyr Gin Met Lys

35 40 45

Asn Met Thr Pro Gin Val Asp Glu Cys Gin Gly Tyr Cys Gin Gly Glu

50 55 60

He Tyr Asn Trp Leu Arg Ala Tyr Asn Ser He His Gly Tyr Val Ser 65 70 75 80

Leu Met He Cys He Phe Gly Thr He Ala Asn He Leu Asn He Met

85 90 95

Val Leu Thr Arg Lys Glu Met Ala Lys Thr Pro He Asn Asn He Leu

100 105 110

Lys Trp Leu Ala Val Ala Asp Met Phe Val Met Leu Glu Tyr He Pro

115 120 125

Tyr Thr Ser Tyr Gin Tyr He Tyr Met Gly Pro Gly Glu Lys Asp Leu

130 135 140

Ser Tyr Thr Trp Ala Val Cys Leu Leu Val His Met His Phe Thr Gin 145 150 155 160

He Leu His Thr He Ser He Gly Leu Thr Val Thr Leu Ala Val Trp

165 170 175

Arg Tyr Val Ala He Arg His Pro Asn Gly Gly Cys Ala Asn Phe Leu

180 185 190

Leu Ala His Ser Arg Glu Ala He Leu Leu Pro Phe He Leu Ser Pro

195 200 205

He Leu Cys Leu Pro Thr Tyr Phe Val Phe Gin Val Arg Glu Thr Tyr

210 215 220

Asp Val Asp Lys Val Asn Ser Glu Ala Met Tyr His Val Tyr Phe Asp 225 230 235 240

Lys Asp Ser Val Leu Tyr Arg Phe Asn Phe Trp He His Ser Val Leu

245 250 255

He Lys Leu Leu Pro Cys Gly He Leu He Val He Ser Ala Val Leu

260 265 270

Met His Val Leu Cys Glu Ala Ser Arg Arg Arg Leu Lys Leu Arg Asp

275 280 285

Tyr Asn Asn Pro Ala Lys Tyr Ala He Gin Leu Asn Leu Asn Glu Thr

290 295 300

Lys Ser Lys Lys Pro Pro Arg Cys Asp Arg Arg Asn Asp Arg Thr Thr 305 310 315 320

Leu Leu Leu Val Ala Val Leu Val Leu Phe Leu He Thr Glu Phe Pro

325 330 335

Gin Gly Leu Leu Gly Leu Leu Ser Gly Val Met Glu Lys Cys Phe Phe

340 345 350

Ala His Cys Tyr Pro Pro Phe Gly Glu Leu Met Asp Leu Leu Ala Leu 355 360 365

186 He Asn Ala Ala Val Gly Phe Val Leu Tyr Gly Leu Met Ser Lys Gin

370 375 380

Phe Arg Thr Thr Phe Arg Ser Leu Phe Met Lys Arg His Phe Gly Ser

385 390 395 400

Thr Glu Met Thr Arg Leu Thr Arg Val Thr Thr Thr Cys Val 405 410

<210> 145 <211> 4116 <212> DNA <213> Drosophila

<400> 145 gttaaatgat ttacaaacaa gccgacatct cgggaaccat taaagagaca tttaaagtca 60 aaaagtggcc aactgaaacc cgttaaaatc cgcttgcgac cgcaacttgg cccgactaag 120 gcaaaaaata acataatcct gtcaagtcat gcagacaggg cgatttacat tataatttta 180 aatggcaatg gattagtcat catcagtacc tgcttatctg gttttcctga tttttaaatc 240 aaatctgtga ctgtatctct tacctttcct cttgtacctc gttattataa aatgcgaaaa 300 ccctctgcca aaggacacta taaaacgaat tttttaaaag acgccaaaca aaatggcact 360 ttttgttgag aagaaaatat gccgataaga acgttttact tgtaagacgc tgcagaaaga 420 ttaggaacga aaactatcga caatgtttac ttgtataatc tgagctttct aaaacacaaa 480 aatagtgtac ttttaccata cgcttaattt cgaaattaat ccgggatata cagttgggga 540 tccagatttt aaattcgtga acacagctgc tggagtaggg catttcctga tcgatctgtt 600 agttttcgga cttttacttt ggttgttgta aacaatatcc gcaagtttct cgcaaagtgg 660 gttgcgttgt gccgtgcctc agtagagcac tacacactac cttcgattga gttcgctggg 720 atttggattt cgttcacagt ccaagtttgg accgtgctag gagaagataa tgatccgatc 780 actcaattaa cttcatgcac ccagtgacgt catcagtgct ttactattcg gtgtctatat 840 agtctatttt gtttaatttc ttacacccta catttcgata cgattcgatt ttcgtttgga 900 aattgtctga aggtaaacaa gcataaattg gacgttcaag cgtaaacaaa tcggttttcg 960 gagcaaaata caaaaatcgt cagttgagaa agtctctcaa atggcgcagt tctgcattct 1020 tggagtcctc ctcattcttt ctggaacaca ctgctcgtgg ggattccatg aagagacaca 1080 ttatccgtgt gcctttatcg atacggcaaa cataacgggg agctacggct tagatggccc 1140 atttgtgcac aactggacgg tgattccccg tcacttcgta gccgtgtacg actttgtcat 1200 cgaaaatggc atccgcatcc ccgcaagcag gcatctcaga gcctgtgtct gtaagaccaa 1260 accctgtgta cggatttgct gtttacgggg agaaatctac gacctggaga agaggcagtg 1320 cttagtccct gtggccgggg tgtccagcct tccctcccat agccatatgg aggtggagtt 1380 gggcaacggc agtctgcgtc tagtgaaact gcaaccccgt tttagcatcc acgtggaaac 1440 accatgtgag cacatgaaag ccgtaaccaa gggctcggaa tacgttcact ggacacttca 1500 tgaggtcggt tgtgaaataa accttccatc acattaatgg ctttacatcg ccttttcaga 1560 acggaaccat cagccaccga ggacacatat tttctaagca ttactgcttc actccgctgc 1620 tccatgggaa ctccacctgg gagtggcagc cattggcctg tgcaccagaa aaactatatt 1680 tcgtcttggg ggtgcgggag tggacatacg ccatatgtaa gtagcaagag gaaacatttt 1740 tccagcaact ttcagcaatt cattatccca aatatgcaca atactgtttt cacaacaata 1800 cataaaagta attgctaaag caccaaaaaa caatcgatga tagcattaat agtttgatag 1860 tcagaattta atttacccag cgtattcact ttccaggtct cttgatagct attctatcaa 1920 tgtttatcgt gctgatggtc taccttatgt gttcggaaat gcgcaacagt ttctacggtg 1980 tggccataaa ggcgtacgcc atttgtatga tcttgggata tgccctactg gcttatctca 2040 cgctccacaa cccagcaaat ctctcaaatg cggcttgtcg tattctacgt aagtggtaaa 2100 tttgagtatt ctgtgatatt taaacattcc cttctttttt ttttttagca agtttggcgt 2160 tgatgaactt ggtgctttcc ttttacattc tgagctttat tgcatttaag ctgtacttga 2220 gcttttatgg cgttgtcttc acaaaactga tgttttggct aatatttact cccatcgtac 2280 tggtagccgt gggctggtct ttctttgtgg gtttcagtta ttacggctct aggctcatct 2340 tcggaggcga tacatgctgg tttgatcgta agcactgcca atccatatat gttttataat 2400 aattaattgg tattccacat cgctagcacg caattggtcc gttatgatat atttttacgc 2460 tcctgttttc gtggcttgcg ccattagcgg tttcttctat gtcctgagcc agatctacat 2520 ccgtgatcag ccagatatcg agacggagaa gagcttcgag tccatagaga agaaccgatt 2580 caaatcattt tggaagtact ttggctacac ggcagtcgta tgggtcgttt gcatatgctc 2640 ctttgccttt aactactact gggagaacag atcccacctt aactacgctg taagcttctg 2700 catggccttc cacgggtttg cggccctcta tgcgctgatt ggaaagaatc agcaaatcca 2760

187 aaattttctg cggcgcatag ataagtaagt tgataactat gaattttaag tactactgtt 2820 aatatatact gttgcagtgg cgaagatacc tgtgaaaact cagttccgct ctcgagtttt 2880 ggttaacttt tcttgttgtg cccactgtag cgttagtgta actggaagca gttgagtgta 2940 tcgacaatat ctgtgcaatg tttttaaaat cacttatcag catagacaaa aaccatgtat 3000 tttaaatgta aaattttgta ggatgtgtgt aaaatatatt tgtaaaattt gaactcgaac 3060 aaaaaagtac acttctaccc tttaaacgaa attacgataa taaagataca aaaaataaat 3120 atatctgaaa aaaaaatcag gtctggaatt tctacaattg ttaaatatga taacaagtcc 3180 caacaatcct ttcagtatag aacaaaacat ggaatatact taagccatgt gaaagaacac 3240 ataacatatt aatattctaa acaatttgag cagttttctt gagtttacgc ctccaacaat 3300 ttatccttca cctttcttga gttccaaatt cctggaccgt gatcaagttt ctccagtctt 3360 atttcaagtc ccgattttac tgtaccctat ccgcatcgcc aagcccggtg ttacttcccc 3420 gatctctcta tattataaat gtgcgccgat tttatttaac atcagaggtc aatggccgca 3480 aaacagacag agagagagag agagaaagtt ggtcagagcc acgagaactg catcccgaca 3540 gggggctgtc aagagcaagg aatcaagtgg aatgttggtg gtgctctttt gaaaaggctt 3600 cgcaaacttt ccccctgtac acccccttgc caaggcctaa tcgcagaaaa cccacccggg 3660 tcggagtccc caattcattt tcatgccgat tatgcttcgg gttttggtcc tgctcttttt 3720 ggctgggcgt acagcagcag gactcggggt acacactaag agaggtctaa gaatatagag 3780 atagacaagg aaagcagatg gatcgataaa acgtagtaaa aatgctcgta gtaatggaag 3840 ctggaaataa catggcacaa acaggcccca aactgcatcg acaacaccat cacaatccag 3900 acgtgcgcac tggaaaatcc cgagaggtag gacatgtttg gcgcgttttt cgactgcatg 3960 tgtgcgagtg ttctgttttg gttagatacg tatgaaaaag tgaaaaagcc tatattgacc 4020 gcgcccggta gatcgcatag gcaatatcga tatgggaaat cattgactaa catttgcaga 4080 catttagttt gggacacatt aaagttaatt tgactc 4116

<210> 146

<211> 1709

<212> DNA

<213> Drosophila

<400> 146 atggcgcagt tctgcattct tggagtcctc ctcattcttt ctggaacaca ctgctcgtgg 60 ggattccatg aagagacaca ttatccgtgt gcctttatcg atacggcaaa cataacgggg 120 agctacggct tagatggccc atttgtgcac aactggacgg tgattccccg tcacttcgta 180 gccgtgtacg actttgtcat cgaaaatggc atccgcatcc ccgcaagcag gcatctcaga 240 gcctgtgtct gtaagaccaa accctgtgta cggatttgct gtttacgggg agaaatctac 300 gacctggaga agaggcagtg cttagtccct gtggccgggg tgtccagcct tccctcccat 360 agccatatgg aggtggagtt gggcaacggc agtctgcgtc tagtgaaact gcaaccccgt 420 tttagcatcc acgtggaaac accatgtgag cacatgaaag ccgtaaccaa gggctcggaa 480 tacgttcact ggacacttca tgagaacgga accatcagcc accgaggaca catattttct 540 aagcattact gcttcactcc gctgctccat gggaactcca cctgggagtg gcagccattg 600 gcctgtgcac cagaaaaact atatttcgtc ttgggggtgc gggagtggac atacgccata 660 tgtctcttga tagctattct atcaatgttt atcgtgctga tggtctacct tatgtgttcg 720 gaaatgcgca acagtttcta cggtgtggcc ataaaggcgt acgccatttg tatgatcttg 780 ggatatgccc tactggctta tctcacgctc cacaacccag caaatctctc aaatgcggct 840 tgtcgtattc taccaagttt ggcgttgatg aacttggtgc tttcctttta cattctgagc 900 tttattgcat ttaagctgta cttgagcttt tatggcgttg tcttcacaaa actgatgttt 960 tggctaatat ttactcccat cgtactggta gccgtgggct ggtctttctt tgtgggtttc 1020 agttattacg gctctaggct catcttcgga ggcgatacat gctggtttga tccacgcaat 1080 tggtccgtta tgatatattt ttacgctcct gttttcgtgg cttgcgccat tagcggtttc 1140 ttctatgtcc tgagccagat ctacatccgt gatcagccag atatcgagac ggagaagagc 1200 ttcgagtcca tagagaagaa ccgattcaaa tcattttgga agtactttgg ctacacggca 1260 gtcgtatggg tcgtttgcat atgctccttt gcctttaact actactggga gaacagatcc 1320 caccttaact acgctgtaag cttctgcatg gccttccacg ggtttgcggc cctctatgcg 1380 ctgattggaa agaatcagca aatccaaaat tttctgcggc gcatagataa tggcgaagat 1440 acctgtgaaa actcagttcc gctctcgagt tttggttaac ttttcttgtt gtgcccactg 1500 tagcgttagt gtaactggaa gcagttgagt gtatcgacaa tatctgtgca atgtttttaa 1560 aatcacttat cagcatagac aaaaaccatg tattttaaat gtaaaatttt gtaggatgtg 1620 tgtaaaatat atttgtaaaa tttgaactcg aacaaaaaag tacacttcta ccctttaaac 1680 gaaattacga taataaagat acaaaaaat 1709

188 <210> 147 <211> 492 <212> PRT <213> Drosophila

<400> 147

Met Ala Gin Phe Cys He Leu Gly Val Leu Leu He Leu Ser Gly Thr

1 5 10 15

His Cys Ser Trp Gly Phe His Glu Glu Thr His Tyr Pro Cys Ala Phe

20 25 30

He Asp Thr Ala Asn He Thr Gly Ser Tyr Gly Leu Asp Gly Pro Phe

35 40 45

Val His Asn Trp Thr Val He Pro Arg His Phe Val Ala Val Tyr Asp

50 55 60

Phe Val He Glu Asn Gly He Arg He Pro Ala Ser Arg His Leu Arg 65 70 75 80

Ala Cys Val Cys Lys Thr Lys Pro Cys Val Arg He Cys Cys Leu Arg

85 90 95

Gly Glu He Tyr Asp Leu Glu Lys Arg Gin Cys Leu Val Pro Val Ala

100 105 110

Gly Val Ser Ser Leu Pro Ser His Ser His Met Glu Val Glu Leu Gly

115 120 125

Asn Gly Ser Leu Arg Leu Val Lys Leu Gin Pro Arg Phe Ser He His

130 135 140

Val Glu Thr Pro Cys Glu His Met Lys Ala Val Thr Lys Gly Ser Glu 145 150 155 160

Tyr Val His Trp Thr Leu His Glu Asn Gly Thr He Ser His Arg Gly

165 170 175

His He Phe Ser Lys His Tyr Cys Phe Thr Pro Leu Leu His Gly Asn

180 185 190

Ser Thr Trp Glu Trp Gin Pro Leu Ala Cys Ala Pro Glu Lys Leu Tyr

195 200 205

Phe Val Leu Gly Val Arg Glu Trp Thr Tyr Ala He Cys Leu Leu He

210 215 220

Ala He Leu Ser Met Phe He Val Leu Met Val Tyr Leu Met Cys Ser 225 230 235 240

Glu Met Arg Asn Ser Phe Tyr Gly Val Ala He Lys Ala Tyr Ala He

245 250 255

Cys Met He Leu Gly Tyr Ala Leu Leu Ala Tyr Leu Thr Leu His Asn

260 265 270

Pro Ala Asn Leu Ser Asn Ala Ala Cys Arg He Leu Pro Ser Leu Ala

275 280 285

Leu Met Asn Leu Val Leu Ser Phe Tyr He Leu Ser Phe He Ala Phe

290 295 300

Lys Leu Tyr Leu Ser Phe Tyr Gly Val Val Phe Thr Lys Leu Met Phe 305 310 315 320

Trp Leu He Phe Thr Pro He Val Leu Val Ala Val Gly Trp Ser Phe

325 330 335

Phe Val Gly Phe Ser Tyr Tyr Gly Ser Arg Leu He Phe Gly Gly Asp

340 345 350

Thr Cys Trp Phe Asp Pro Arg Asn Trp Ser Val Met He Tyr Phe Tyr

355 360 365

Ala Pro Val Phe Val Ala Cys Ala He Ser Gly Phe Phe Tyr Val Leu

370 375 380

Ser Gin He Tyr He Arg Asp Gin Pro Asp He Glu Thr Glu Lys Ser 385 390 395 400

Phe Glu Ser He Glu Lys Asn Arg Phe Lys Ser Phe Trp Lys Tyr Phe

405 410 415

Gly Tyr Thr Ala Val Val Trp Val Val Cys He Cys Ser Phe Ala Phe 420 425 430

189 Asn Tyr Tyr Trp Glu Asn Arg Ser His Leu Asn Tyr Ala Val Ser Phe

435 440 445

Cys Met Ala Phe His Gly Phe Ala Ala Leu Tyr Ala Leu He Gly Lys

450 455 460

Asn Gin Gin He Gin Asn Phe Leu Arg Arg He Asp Asn Gly Glu Asp 465 470 475 480

Thr Cys Glu Asn Ser Val Pro Leu Ser Ser Phe Gly 485 490

<210> 148 <211> 3772 <212> DNA <213> Drosophila

<400> 148 agtcagtgcc tggacggatc gcacgagtcc ttctactaag cgctaccagt ggtggtcgta 60 atcccccaat ccaaacccat acccaaagct tcgctgcatt ttcgaataca aacactgaac 120 tatccgtcgt tgtaaagcta ccttatccac tacgattact acactatcct acaaaaaact 180 atgctggtta aaagactata cacctagctc catatactat atatatatat acaatatcga 240 ggcatgtgtt gtgtgggcga gtgagtgtgt gcgtgtgact tctgattgag ttgccatttg 300 attccaagta ttttcgagtg cttagttttg taatttgtag ctagccgtta atgtttgtat 360 aaactgtttc attggtttcc cactccgctt tattcgataa gctcgttttc tagattttag 420 ctttagcact cttagtttaa tgtttaaagt tagtttcgct gttaagttta caccgtagtc 480 gaggcgtctt gagtagttct tttgtacatt aagcttacac ttagctctac attagatata 540 ccatgtcgaa cctacgagtc tacgaacata cgaacatata tatgtgcgtt gaaagcgttg 600 tattttttga agccgaactt atgcaaccga aaggagacaa taaacaaatg tgctataaag 660 gacgaaagtg tcgcaaataa atgtgagcca ctgctaaaga agaccgattt gcgcaaggtg 720 ttttactcgg cggcggcggc aagaagcgtt tggggcacaa acgacggatg agtgattgcc 780 actcgtacca tcatcatgac gatggcgtgt ggaacgacgt gcgcatagta atgacagcgg 840 atggcaatct gaacgataag cggcacccga taatgaaaca ttaaactaaa ccgtcggtag 900 tcgctggcca taaatctgtc ggcagtctgc tcgcagaagc ttttaggtgc ggaccccttg 960 cgcggcatac tttcgggctt ccgttccgtt ccgttcgcca atggccctgc tccactacac 1020 cttcgaccag ctcgagttgt acctagaatg ggcgttcgcc cagcacggag aggccacgcc 1080 gattccctcg atccagccgt atccgggcgt gttcgtgggc gatctcagcc agctgaaccg 1140 cttcaagcga catgccttct ccgccgtcgt gggcacgctc ttcgtcctcg ccttctgcgg 1200 caacctgagc accctctatg tgaacagccg ccggaagctg cggcccttct tccgggcctg 1260 cctcatctca ctggcctgca gtgaccttgt ctccagcata ttctgcaccg tatcctacat 1320 ggcccagttc caggcgcagt atctgcagct ctgggtgagg cggcagggat tgagcagact 1380 caacacaagc taattacaaa tctccttaga caattggtgg cttcatgtgc aagtttgtgc 1440 cgttcataac caccacgtcg gtgttgtccg gcagcctgac cctggtggcc atcgccttgg 1500 accgctactt ggccgtgatg cgacccgtgc tggggttctg gagtcccgac aaacgcttca 1560 gcactctgag catgctgctc atctgggcat gttcgatagg atcctctggc ccgctgctgg 1620 gcatctacga ctaccgaaag atctatctcc tggatgtgga ggactccagc gaggagagcg 1680 aggaggtcgt gaccgctgtg cccgaggagc tggtggtcac cgagctggaa atggttcaca 1740 tgtgcctggc cggggacgta agtcaacgac tggattatcg cttaatacag ttgacagcga 1800 ttaaggggat ttggacgggg ggatgtcaag ttgttgaatc aatgttccga ttatcttatc 1860 agccgcgtcg aaaacaattt atgcaattct ataaatattc cgttttagca cgacgtcgga 1920 ctctactacg tcatactgtt caccctgatc ttcctgccgt gcattgtgtc cttcctatgg 1980 ctgaatgccg tgattgcgag gcagctctgg ctgcggagac actaccacca ggagcagcag 2040 gagcagcatc aggagcccaa ggagggtcag tttaagacca tggcgaatgg cggggatctc 2100 ttgatgccct ccaccttggt cagtgccatg ggagtggccg ttccctttgc gctggacaac 2160 actcccttgc cgcccaagag taccgtcaac gctcctggca agaagaccac tgctgctgct 2220 ctagccaggg aggccaggca ccgcaagatg gtggtggtgg tgctgctaat gatggcggtt 2280 ttcatatgcc ttcgactgcc cgcctgggtc ttcctgatca tgcggcttta tggatcctac 2340 tccgagccca tcgactggct cctgtacttc agcttcggca tactgaacct tttcagttgc 2400 gccctaaatc ccatcttcta caccttcctc acccagacca ttaggacctt gacgctggtg 2460 aaacacaaaa ttcagggatt tcttggctgt ccgcctggta aagtgccgga tggtatgccc 2520 acggatcaga tggacaaaag cgggtgctgc tgcggcctga ggccacccac cttcacatgg 2580 aggtgccatc ccagccgcga tagggcagca gccaccgtaa tccgggatgt ggaccagcca 2640

190 gatccgccct ccgaccaggt gcaaccggat ccgagtagcc tacggcggtt cctcagctac 2700 aagcaggagg tgttcaccat ttacaagcag tgcggtgact cgtcgagtgc gtcaatcgag 2760 tcctccgcct gataggcggt ggtcataaat cacccgggtg catttgtcgg atacgggggc 2820 caacggttag cagaacccca gaacttgatt gatggatgga tccagccccc attcactctg 2880 tacaggcgca aaaacggttt gtcacggtgg gtatatcacc cacgaataca ctagcacgca 2940 tataagatat aagctcacat attatgtacc tcatcaaatg tgtaaatatg aggaataaac 3000 gaatgggtgt tggcagctaa ctaaccatta acacatggcg caatcgaaat cgggaaggtc 3060 tcagctatta ttgtgacgaa aacctaagac ctttcaagta ccacttaaaa ctatatttag 3120 agaacttaag caaattgtga gattaaaatg caatgcaact cctaaaggtg cgaatatacc 3180 tattcttaaa tatttttact ctagaaatac tgacatcttt atgtgcttag ttttcgttca 3240 gacagactat ctttgttatt tctaagaacg tagtaattag ttaatggaat taattagtaa 3300 ccgaaactta aaattgagtc atgccaaaaa aagagaattg gcctgacaag acacacatta 3360 tagagtcagc agatcgtgga cgagacaatg agcccgcaat gcaatggaac tagattgtat 3420 catatactag atacttccgc ttggaacaat ggttaacaga tctcgtgaga gatggggctg 3480 aaagcagttg ttaattgtca aatgttgagc acgccagtta aatttagcta tgcagcgaaa 3540 gctctctccc atactctctt cccatgaact tttttaagcc gcagagcccg aagctcgact 3600 caaagctgaa ttctgcgttt tctggcattc agtgtcggcg gtttgcggcg agcggttgga 3660 ttcggattct ttggtcggta aaacgcgaaa tcttctgtgc ggcgggtgaa atcttcggca 3720 gaagaaacaa caaagcgaca agtgtggagt gtggagtgca taccgtacca eg 3772

<210> 149

<211> 1566

<212> DNA

<213> Drosophila

<400> 149 atggccctgc tccactacac cttcgaccag ctcgagttgt acctagaatg ggcgttcgcc 60 cagcacggag aggccacgcc gattccctcg atccagccgt atccgggcgt gttcgtgggc 120 gatctcagcc agctgaaccg cttcaagcga catgccttct ccgccgtcgt gggcacgctc 180 ttcgtcctcg ccttctgcgg caacctgagc accctctatg tgaacagccg ccggaagctg 240 cggcccttct tccgggcctg cctcatctca ctggcctgca gtgaccttgt ctccagcata 300 ttctgcaccg tatcctacat ggcccagttc caggcgcagt atctgcagct ctggacaatt 360 ggtggcttca tgtgcaagtt tgtgccgttc ataaccacca cgtcggtgtt gtccggcagc 420 ctgaccctgg tggccatcgc cttggaccgc tacttggccg tgatgcgacc cgtgctgggg 480 ttctggagtc ccgacaaacg cttcagcact ctgagcatgc tgctcatctg ggcatgttcg 540 ataggatcct ctggcccgct gctgggcatc tacgactacc gaaagatcta tctcctggat 600 gtggaggact ccagcgagga gagcgaggag gtcgtgaccg ctgtgcccga ggagctggtg 660 gtcaccgagc tggaaatggt tcacatgtgc ctggccgggg accacgacgt cggactctac 720 tacgtcatac tgttcaccct gatcttcctg ccgtgcattg tgtccttcct atggctgaat 780 gccgtgattg cgaggcagct ctggctgcgg agacactacc accaggagca gcaggagcag 840 catcaggagc ccaaggaggg tcagtttaag accatggcga atggcgggga tctcttgatg 900 ccctccacct tggtcagtgc catgggagtg gccgttccct ttgcgctgga caacactccc 960 ttgccgccca agagtaccgt caacgctcct ggcaagaaga ccactgctgc tgctctagcc 1020 agggaggcca ggcaccgcaa gatggtggtg gtggtgctgc taatgatggc ggttttcata 1080 tgccttcgac tgcccgcctg ggtcttcctg atcatgcggc tttatggatc ctactccgag 1140 cccatcgact ggctcctgta cttcagcttc ggcatactga accttttcag ttgcgcccta 1200 aatcccatct tctacacctt cctcacccag accattagga ccttgacgct ggtgaaacac 1260 aaaattcagg gatttcttgg ctgtccgcct ggtaaagtgc cggatggtat gcccacggat 1320 cagatggaca aaagcgggtg ctgctgcggc ctgaggccac ccaccttcac atggaggtgc 1380 catcccagcc gcgatagggc agcagccacc gtaatccggg atgtggacca gccagatccg 1440 ccctccgacc aggtgcaacc ggatccgagt agcctacggc ggttcctcag ctacaagcag 1500 gaggtgttca ccatttacaa gcagtgcggt gactcgtcga gtgcgtcaat cgagtcctcc 1560 gcctga 1566

<210> 150 <211> 521 <212> PRT <213> Drosophila

<400> 150

191 Met Ala Leu Leu His Tyr Thr Phe Asp Gin Leu Glu Leu Tyr Leu Glu

1 5 10 15

Trp Ala Phe Ala Gin His Gly Glu Ala Thr Pro He Pro Ser He Gin

20 25 30

Pro Tyr Pro Gly Val Phe Val Gly Asp Leu Ser Gin Leu Asn Arg Phe

35 40 45

Lys Arg His Ala Phe Ser Ala Val Val Gly Thr Leu Phe Val Leu Ala

50 55 60

Phe Cys Gly Asn Leu Ser Thr Leu Tyr Val Asn Ser Arg Arg Lys Leu 65 70 75 80

Arg Pro Phe Phe Arg Ala Cys Leu He Ser Leu Ala Cys Ser Asp Leu

85 90 95

Val Ser Ser He Phe Cys Thr Val Ser Tyr Met Ala Gin Phe Gin Ala

100 105 110

Gin Tyr Leu Gin Leu Trp Thr He Gly Gly Phe Met Cys Lys Phe Val

115 120 125

Pro Phe He Thr Thr Thr Ser Val Leu Ser Gly Ser Leu Thr Leu Val

130 135 140

Ala He Ala Leu Asp Arg Tyr Leu Ala Val Met Arg Pro Val Leu Gly 145 150 155 160

Phe Trp Ser Pro Asp Lys Arg Phe Ser Thr Leu Ser Met Leu Leu He

165 170 175

Trp Ala Cys Ser He Gly Ser Ser Gly Pro Leu Leu Gly He Tyr Asp

180 185 190

Tyr Arg Lys He Tyr Leu Leu Asp Val Glu Asp Ser Ser Glu Glu Ser

195 200 205

Glu Glu Val Val Thr Ala Val Pro Glu Glu Leu Val Val Thr Glu Leu

210 215 220

Glu Met Val His Met Cys Leu Ala Gly Asp His Asp Val Gly Leu Tyr 225 230 235 240

Tyr Val He Leu Phe Thr Leu He Phe Leu Pro Cys He Val Ser Phe

245 250 255

Leu Trp Leu Asn Ala Val He Ala Arg Gin Leu Trp Leu Arg Arg His

260 265 270

Tyr His Gin Glu Gin Gin Glu Gin His Gin Glu Pro Lys Glu Gly Gin

275 280 285

Phe Lys Thr Met Ala Asn Gly Gly Asp Leu Leu Met Pro Ser Thr Leu

290 295 300

Val Ser Ala Met Gly Val Ala Val Pro Phe Ala Leu Asp Asn Thr Pro 305 310 315 320

Leu Pro Pro Lys Ser Thr Val Asn Ala Pro Gly Lys Lys Thr Thr Ala

325 330 335

Ala Ala Leu Ala Arg Glu Ala Arg His Arg Lys Met Val Val Val Val

340 345 350

Leu Leu Met Met Ala Val Phe He Cys Leu Arg Leu Pro Ala Trp Val

355 360 365

Phe Leu He Met Arg Leu Tyr Gly Ser Tyr Ser Glu Pro He Asp Trp

370 375 380

Leu Leu Tyr Phe Ser Phe Gly He Leu Asn Leu Phe Ser Cys Ala Leu 385 390 395 400

Asn Pro He Phe Tyr Thr Phe Leu Thr Gin Thr He Arg Thr Leu Thr

405 410 415

Leu Val Lys His Lys He Gin Gly Phe Leu Gly Cys Pro Pro Gly Lys

420 425 430

Val Pro Asp Gly Met Pro Thr Asp Gin Met Asp Lys Ser Gly Cys Cys

435 440 445

Cys Gly Leu Arg Pro Pro Thr Phe Thr Trp Arg Cys His Pro Ser Arg

450 455 460

Asp Arg Ala Ala Ala Thr Val He Arg Asp Val Asp Gin Pro Asp Pro 465 470 475 480

192 Pro Ser Asp Gin Val Gin Pro Asp Pro Ser Ser Leu Arg Arg Phe Leu

485 490 495

Ser Tyr Lys Gin Glu Val Phe Thr He Tyr Lys Gin Cys Gly Asp Ser

500 505 510

Ser Ser Ala Ser He Glu Ser Ser Ala 515 520

<210> 151 <211> 8599 <212> DNA <213> Drosophila

<400> 151 aggacacatt ggcgtactta gtctagacca ctgggtgagc ttaatgtttt gccgttcggt 60 tatatatcat gcggtgattt gtggacttag cataaaacct aactgaacgg cccggcgaca 120 tcccgactct ctggcgactt tggacgggcc acgataaatc aaggcgcaga tccgggagcc 180 cggcatatag tggatatagt atgcgtggcg aaacttaata agagatgcga caacaaacaa 240 atgatacaga tagacagacg gcaggcgaca gtcgcggtgg tgcgagaggt gggtaggtgg 300 gtaggtggga aatgggattg tggaaagcgg aaaaatcttt aaagcaatgc cgctgcacag 360 gacatttttc accgcgccat ccattcgcag acggatcgcc aaagagagac atcaacgtga 420 ctcgcgggga gaacaagtgt tttgatttat cgccagcaat ggcaatggca gggcggacgg 480 ggattgccat ccaattatac tgctaacttt cattatgtca ctgtgctatt tcgggaccgg 540 attcgccgcc atattggccc attgttgcgc cattgtctat gcacagctct ctgtttagca 600 gtgacacact gcggtttcgg tggcaggact catctccatc ctgccgcctg ccttagtcgt 660 cccttgccgc ttcctcggtg gactccgtct gataaatcgt cagcgcggct tccctttcac 720 atgctttgac ttcattatgg cgtaacaaat cgtcggcatt ttgcattcct cgctgcggaa 780 acggaagcgg aagacatccc cgaaagaaac tgcgaactgg gcctttgtgg ccacacgacg 840 aattggtcac gcgccatata gacaattcca tctcagtttt ccacatgttt tgattgctca 900 acgttgtcaa gggactttgt gctgctgtac ttttttcgct tacactttaa tagcttccga 960 agagactcat atccttcata tcctttcttg cagctctgcc atggatctaa agactggctc 1020 tctcctggta gcacccgccg tgaagaactc cagctgctcg catccgcgct actccggcca 1080 caatttcatc gcccacatag ggattgcgga gaccatcgag gcggtgctca tcctggtcct 1140 cacactgggc gtcatcgggg ccaactgcct ggtcatcttc gtcatcaaca accgccgcta 1200 tgcggcctac atacaccaac aggtgggagg ctgagtcact ggcttaacac cttgtacatc 1260 ttatgtctct ccttgtagcc ccgttatctg ctcacctcgc tggccctgaa tgacctgaca 1320 attggtctgc taattacacc attcggtcta atgccggcat tgttccactg ctggccatac 1380 ggagagatct tctgtcagat acaggtgagc gggtcaagag tgggtcaaca ccaggtcaac 1440 aagtggggcg gaagtgcgat aatttgttat ggaacacccg tctcccgttt gcggctgttg 1500 ccactgcggt caattaactc tctcttaaca atgcacagta attactggac ataaatggcg 1560 gtgatggaaa cggacaatcc cgattaacgg gcggaacaat gtgtaatgct agtattaacg 1620 tggtcgagag tgtgtaggat tctgcggtaa gagtcagggt tccgatgcag aaggtgtgac 1680 aagcggaaag ttatcccagc catatggtta ggaagctagt gcacatggaa aaaccattgt 1740 gccattaatt atcatgacgg tggacagggg gcatcgtggt tagggtgtgc aacagaaact 1800 gttagtttat cacttatcaa gtgtcaaaaa gcatgcaacg aaatcaccta gaatccatca 1860 caacaattgt tgcatacatg cttaaaaagg ttgggttttt atgaaaatca gagttgtaaa 1920 cattgtaata aaatccagtt aacactcata caactatttt catgggaacc agactcttgt 1980 tatatatttt atacgatgtc gtttcacaaa atttgaattt tccaactgcc actttagggt 2040 tattggtaaa acatgcacgc attccacgca taactctcac aaatattgaa acacatactg 2100 acgattaata attttattaa aagtttttcg attcgcctcg acaagcgaaa aagtttgccg 2160 aaagcaataa tacaaataat aaacttctaa acgagcacta acgcattttc tggctttttc 2220 gcgttttcca ggccctgctc cgaggggcgc tttcccagca gagcgccgtc atcctggttt 2280 gcatggcagt cgatagatac atgtgtgccc tgcatccgcg ccgctactac cagcactcca 2340 gcaagaaggt aagattccac gtcctatcgc ctcgcatcga tagggaactt ctattttggg 2400 ttgcccggat aaggcacgct cctcggcgat ccttatcctg ttgttcttgc actcgcgctc 2460 gcgctcggaa ggacaataaa caaagctccg gcataatgac gagaaatcac gcgccaataa 2520 aatcgactat aacaatggga agagcaccgc acagcaacta cacaatatgg tcggcgagcc 2580 aattacgcaa gcataaataa ggataatggg ctttaagcag cttgacagtc attaaacagg 2640 caaaaaatgg gtgggcagcg ccaaagagca agtgcaaaac aaagcatcat ggagaatgaa 2700 aaagcaaagt tggcaaaaac caacaaaacc gaaaaaaaaa acaacggggg ccaagtcgaa 2760

193 tagacattcg aaaagtgtat aaaatgtgga taaaaaaaag ggagcaaagt tggcctagag 2820 attttttacg cgcaatgact tcggcacagg gcgacgacca cagcaaagtc cttttccagg 2880 acgcaggcag gcaaatgaag cggcacctcc cacggaaacc gcagccagga ccaaagagca 2940 gcaaacgagc tctcaaccaa ccctatttcc cattcccccc ttcgtaattt atggctcccg 3000 gactgtaaac aaacgaaaac taggaggcca acagtcggct aagaacaccg aagtccgaat 3060 gtccttgtcc caaatgaacg ggactgtttc agctgaaatt ggcgatcaat aaatgtatag 3120 tttagaatcc atttcccgca aaattcaagc taacaaacag attttagctt acatatatga 3180 ttatttaacc tttttgattt acagtcttaa tttctcgctg tttgcttggg gattttgcaa 3240 acagttgtaa ttactaaact aactaaaaaa ggaaaatgcc atcaggccaa ataaaacaat 3300 tggaaaacgg gaaagtacca atagtggaaa ataaatttac ataacaattt tgtatgctcc 3360 gaaaatcggc gccatttcgg ttttttcatg ccatctggac gagtgggcga aattggcgca 3420 ctgccacgcc ccatttgtaa aaatgatggg cgcagtgtcg aaaattaata aatggatgct 3480 gaatgcgaaa tactggggat gctgaaaaac caatgctcgg cggaactcgg taatggtaat 3540 tgggaacttt tgactttcgt ttttgcttac tttcaaaagt gccataaatt caaagccagt 3600 cttggacata tctctttatt tatagtgaat ttaacagctt gactcaaaac tcgtcttgtt 3660 gttcgccact cacaatttgt attaaatgca cttgaaaatt caattatttt gttatctagg 3720 atatttgctg actatcctta caacttcagc agtcgccggg ttgtgctcta cgaaaaactc 3780 ctgcaatcct gcaaaaaaaa aaaataatat ttacatttca aaaattgtac ccaactgttt 3840 gagatcgccc tgctttgttt gtttcgttcg ggaaaagttt taaatgtgat agcgtaaatt 3900 aaattaatca cagccatggt ccgtttcaaa gagacacgga caaaagttga gcttcccttt 3960 tttccatgac tttttggcac ttgggatggg gccattttca ttttttcagg tggacaggtg 4020 gacaacattt tcccattcag gatgtcagaa tgctgcattt agtaactcag ccagtcagtg 4080 cgattgtggc agcacttttc cacttccaaa gagcggaagt atcgctttcc ctctgtggtc 4140 tgcacccttt accaagtgat tttggcataa tcaaaagttt gtaattctat ttttggcctc 4200 ttggactccc ttgttgaatg tcagacgaaa tgtgcagtga agcgagtgga attttagcaa 4260 attagaaagt tgaagaggga atttccgact tatctgcacg ccttagtgtg atataagcca 4320 cttccggcta aataaacact taatatgaat tacccaacct tcattcattt tcaattcagt 4380 attggccata ttggcctgaa atgcagggaa tacgtgcctg aagcccttcg ccagtcataa 4440 atcagaccgc acctggcgga aatgtgctcc actaattgtg tattcatttt gcagggctgc 4500 gtggccatac tgagcttaac ctggattatc agcctgacgg tgtttggctt tctggtgctg 4560 cccaaaggtg agctgcccga gattggcccg acatcaatgt gctctcgaac acgtcaaacc 4620 ataaactata tgcgcaggtt actacttcaa caatacgggt ctaatggcct gcgagccctt 4680 ctacagcaag ccatcctaca ggatactgtc cacgtgcgcc ctctactttc ccacgacgat 4740 ggtgctgatg tactgctacg gctccagctt ccacatgagc cgcttccggc taaacgatcc 4800 gaccatgccc ctcacggcgg ccgcccacca cccccatccg cacccacatc ccaccgccgc 4860 ccagcagctg cagatgcacc agcaccagca acatcaccag caggcgggaa tgcactcgca 4920 cctctaccac ggccactcgc atcaccccag ccaccccagt cacccaaacc accccaacca 4980 ccacggccac ccccaccatc atggaccgcc cgttatgggc catctcagca tggccatgag 5040 catgggactg gccggcatgc cgaacatgac aaacaagatt accaaaaagg tgagccagct 5100 gaaccgggtg aactgaggaa gccaggtggc ctgctggcca aaaggatgaa gatggatgaa 5160 ggaggatgaa agaggatgaa gtgggcgggc tccacaacag tttgctcagg cgggcgattt 5220 ggggattaag ttagcagtaa atagaatttt ctcggcatcg ccaaacaaat tgttgggtct 5280 atcagtatgc actcgcagaa cttaaagaag tgttaacagc ttttagtatt tgtgaacggg 5340 ctattcaata ttggtaccag ctaattcaat taaattccag aactcaggta aactaaacta 5400 aaactcactt aaaaaagaac tcgagttgtg caagttactt tacttacttt ccgtgcataa 5460 aaatatttcc agaagccaat attacatttt agcaaaatag aaagcagcag aagttgcatt 5520 tgaaaatata tagaatactc aactatattg ctaataaaca ggaatagaaa tttcgtttgg 5580 gcagtatcta cacataattg aatcaacaat agtcacttta attcaatcgc cgcaaacatt 5640 cccacagatt gttcccatcc aagagaagaa ctccagcgga tccacctcgc gctcgatggc 5700 cgccatttca ctgggcttca tagtgatggt cactccgtgg acgattcagg aaatagtcac 5760 cgcctgcacg ggatccaagg caagtgtcct gtacaaagga ttattgtgtg accgctttgt 5820 gctccgtaca acgcggcgca tacataatga ggtcacgcgt ggctcatcag ttttgatttt 5880 gtgacattta atgttctatg tccgtccaca gctgccgccg ttcctcgatt tcctggtcac 5940 ctggacggcg ctgagcaata gtctgtggaa cccgttcatg tactggctgc tgaactccga 6000 tttccgccgc atgagtcgcc agctgatgcc gaacaaagtg agtatcgggt atccaacagt 6060 gggaagatga atctcctctt ctggcgctaa tttactgcat ctctgatctg gagcgatgtt 6120 cactgtccgt ttcagcagca aatctgccat aagccctgat tgattgattc gcttatccct 6180 attccaaaca ccacgtgcac actttcattg acctccccga acgccaatcc ccaagcccaa 6240 atatgggtat ttcgcccaag tgcatcctgc agctcgcaaa ttttcctcct gcacagcgca 6300 aagtttgcaa aaacaggagc tacatcctcc cgaaagcccc cataaatccg taaccgaagg 6360

194 tgtaagctcc agaatgctgg cagactgacc cgggcaaagt aaacaatcaa ccgacgcagc 6420 aacaacaata gcaggtcctg caaagtgatt ttgaattatg aaagagcaaa tctaagacgg 6480 catttacatc ctcgtagccc cacaaacccc atcccatagg tcctgattcc attttggtaa 6540 acgcagtcaa gttgcatgat ttacttccgg agagccgggg tcagtctgtg gaatatttat 6600 ggcccaacct tgtgctctgc cagaataaat gcgcatttaa aatccttatt aatttttgtg 6660 cgagtcggaa tttatgatgc ctccctgccg tttcagtgct tcccccacga ggatacgccc 6720 gagcacaaat caggctgttg tcacatcaat gctaacgatt tcgaaatcac aacgcttccg 6780 attcccccgg agccgccatc atcccgtcct ccgggcggag caggaggagg aggtggaggt 6840 ccatccagtg gaggtcccag ctctggcggc ggagtggcca gttccattgg cggctccgtc 6900 cttggaatct gcggccgctc gcgcacaaac agcctcagcc gcagcgcctc ccagtacatc 6960 cgagggacaa tgggcggagg agtccacaat caccaggcca cggaaacctt ctccaccacg 7020 aggcctgaca ttgagggcct ctccgagaag tactggggcg agatcctgga gagaaccgtc 7080 agctcgggca acctgaatgc catgcagaag cacctgccgc cccacctgcc ctacgcccac 7140 cacctggtcc accagatcca ccagccgcag cagcaccacc aacagcagac cacctccttc 7200 agcaaggcca gcgatctgca gctgaacctg aacctcagcc aagcagccac ggctgccgag 7260 ctgggcaagt tctccaactc ggagccgaag ctgtgcgagc acctctttca cgacgtaaac 7320 tgcgccaaga gcaaggccgc caacggggat ggggagtcct ccggcaagct ggcctgcggt 7380 cgcagcattc cggacatcta gtacgccgag gacgtgatcc tggccaagaa ccaactgctg 7440 gccaggcagg ccaagtgctc gcaccatccg ctgcaccagc aggccaagac gcgtctccat 7500 tcccacacgg gcagcctgcg cttcagccgg attcgcgctg cctgccacag tccgccgccg 7560 gagaagtccg cctttccaat ggccgagtat cgcaagtagg atcacagagg gcactgggat 7620 caaggatgcc gggatacggt actccaggat gtccaggata tggtataacc atgcacagaa 7680 tagggagtga gagcgagcga gtatctataa gattccatag gtgtatgtgc gtgtgagtgt 7740 ctatataata ccgcatgatc aaaccataat atgtgtgttt tctattaggc ttaagatcta 7800 ggaggtcctt tggttgggtt ttcaatttaa agtctctgag attcgcaaaa tacccatggc 7860 ctgtagaaag cgccctgaag cctaactaaa agaatatgaa agatagcacc tatcctcaga 7920 tattccactc tttatataaa gtaatctgtg ttggttataa cctgaatgat tgctgtccat 7980 ctgagaactt tcaataccat tagctagact ttctttacta tacatggatc tggggaatcg 8040 gaattagccg agttaagcag aagttaacca tagtaagtgt tcattcaatg tttgtgatac 8100 cctaagtttc ccagcccaac atacatacct accagtaaca tataatataa tcctagttgt 8160 tgtgcgtgcg tcggctaaat taaacgtagg atatatggaa acagagatat cagactttcc 8220 tatcagaacc cgctcgacat tcggaagccc ttcgccaaat tctccaccac ttagggacta 8280 aggatctacg tagactctga tatcggcgga ccttaaagcg ttgtggttaa tcatagttgt 8340 agttccatag ctcgagtcgt atacaccaaa ttactcactg ttcgacgaat caaaatcaaa 8400 tcctaacttt gtgattgtca agaatttaag tcggttgatg tggacattgc tgttaaatta 8460 atttttattt gtagctaagt aattgactag ttaaagccaa ataaatttac cgtttaagta 8520 agtctaactt tagttaaata aacgagcggt gtgtaacaaa tgtatttcat aggcagagga 8580 ttcaaatcga aataaataa 8599

<210> 152 <211> 2121 <212> DNA <213> Drosophila

<400> 152 atggatctaa agactggctc tctcctggta gcacccgccg tgaagaactc cagctgctcg 60 catccgcgct actccggcca caatttcatc gcccacatag ggattgcgga gaccatcgag 120 gcggtgctca tcctggtcct cacactgggc gtcatcgggg ccaactgcct ggtcatcttc 180 gtcatcaaca accgccgcta tgcggcctac atacaccaac agccccgtta tctgctcacc 240 tcgctggccc tgaatgacct gacaattggt ctgctaatta caccattcgg tctaatgccg 300 gcattgttcc actgctggcc atacggagag atcttctgtc agatacaggc cctgctccga 360 ggggcgcttt cccagcagag cgccgtcatc ctggtttgca tggcagtcga tagatacatg 420 tgtgccctgc atccgcgccg ctactaccag cactccagca agaagggctg cgtggccata 480 ctgagcttaa cctggattat cagcctgacg gtgtttggct ttctggtgct gcccaaaggt 540 tactacttca acaatacggg tctaatggcc tgcgagccct tctacagcaa gccatcctac 600 aggatactgt ccacgtgcgc cctctacttt cccacgacga tggtgctgat gtactgctac 660 ggctccagct tccacatgag ccgcttccgg ctaaacgatc cgaccatgcc cctcacggcg 720 gccgcccacc acccccatcc gcacccacat cccaccgccg cccagcagct gcagatgcac 780

195 cagcaccagc aacatcacca gcaggc:ggga atgcactcgc acctctacca cggctDactcg 840 catcacccca gccaccccag tcacccaaac caccccaacc accacggtcca cccccaccat 900 catggaccgc ccgttatggg ccatctcagc atggccatga gcatggg; 3Ct ggcctggcatg 960 ccgaacatga caaacaagat taccaaaaag gtgagccagc tgaaccggat tgttcccatc 1020 caagagaaga actccagcgg atccacctcg cgctcg;atgg ccgccatttc actgggcttc 1080 atagtgatgg tcactccgtg gacgalttcag gaaatacgtca ccgcctgtcac gggatccaag 1140 gcaagtgtcc tgtacaaagg attattgtgt gaccgctttc tgccgcctgtt cctctgatttc 1200 ctggtcacct ggacggcgct gagcaatagt ctgtgg;aacc cgttcattgta ctggctgctg 1260 aactccgatt tccgccgcat gagtccgccag ctgatgc :cga acaaatgctt cccccacgag 1320 gatacgcccg agcacaaatc aggctgttgt cacatcaatg ctaacgalttt cgaaatcaca 1380 acgcttccga ttcccccgga gccgccatca tcccgtcctc cgggcgg;age aggaeggagga 1440 ggtggaggtc catccagtgg aggtcccagc tctggcggcg gagtggccag ttccattggc 1500 ggctccgtcc ttggaatctg cggccgctcg cgcacaaaca gcctcagt :cg cagcgcctcc 1560 cagtacatcc gagggacaat gggcggagga gtccacaatc accaggccac ggaaaccttc 1620 tccaccacga ggcctgacat tgagggcctc tccgagaagt actggggt ;ga gatcctggag 1680 agaaccgtca gctcgggcaa cctgaatgcc atgcagaagc acctgcccgcc ccacctgccc 1740 tacgcccacc acctggtcca ccagatccac cagccgcagc agcaccacca acagt ;agacc 1800 acctccttca gcaaggccag cgatctgcag ctgaacctga acctcagt ;ca agcatgccacg 1860 gctgccgagc tgggcaagtt ctccaactcg gagccgaagc tgtgcgacgca cctctttcac 1920 gactacgccg aggacgtgat cctggcrcaag aaccaac :tgc tggccaggca ggccaagtgc 1980 tcgcaccatc cgctgcacca gcaggccaag acgcgtctcc attcccacac gggcagcctg 2040 cgcttcagcc ggattcgcgc tgcctgccac agtccgccgc cggagaacgtc cgcctttcca 2100 atggccgagt atcgcaagta g 2121

<210> 153

<211> 706

<212> PRT

<213> Drosophila

<400> 153

Met Asp Leut Lys Thr Gly Ser Leu Leu Val Ala Pro Ala Val . Lys Asn

1 5 10 15

Ser Ser Cys ; Ser His Pro Arg Tyr Ser Gly His Asn Phe He : Ala His

20 25 30

He Gly Hei Ala Glu Thr He Glu . Ala Val Leu He Leu Val . Leu Thr

35 40 45

Leu Gly Val . He Gly Ala Asn Cys Leu Val He Phe Val Hei Asn Asn

50 55 60

Arg Arg Tyr ^■ Ala Ala Tyr He His Gin Gin Pro Arg Tyr Leui Leu Thr

65 70 75 80

Ser Leu Alai Leu Asn Asp Leu Thr He Gly Leu Leu He Thr ^■ Pro Phe

85 90 95

Gly Leu Met . Pro Ala Leu Phe His Cys Trp Pro Tyr Gly Glui He Phe

100 105 110

Cys Gin He ! Gin Ala Leu Leu Arg Gly Ala Leu Ser Gin Gini Ser Ala

115 120 125

Val He Leut Val Cys Met Ala Val Asp Arg Tyr Met Cys Ala . Leu His

130 135 140

Pro Arg Arc 1 Tyr Tyr Gin His Ser Ser Lys Lys Gly Cys Val . Ala He

145 150 155 160

Leu Ser Leui Thr Trp He He Ser Leu Thr Val Phe Gly Phei Leu Val

165 170 175

Leu Pro Lys ; Gly Tyr Tyr Phe Asn . Asn Thr Gly Leu Met Ala . Cys Glu

180 185 190

Pro Phe Tyr ^■ Ser Lys Pro Ser Tyr Arg He Leu Ser Thr Cys Ala Leu

195 200 205

Tyr Phe Prei Thr Thr Met Val Leu Met Tyr Cys Tyr Gly Ser ^■ Ser Phe

210 215 220

His Met Ser ^• Arg Phe Arg Leu Asn Asp Pro Thr Met Pro Leui Thr Ala

225 230 235 240

196 Ala Ala His His Pro His Pro His Pro His Pro Thr Ala Ala Gin Gin

245 250 255

Leu Gin Met His Gin His Gin Gin His His Gin Gin Ala Gly Met His

260 265 270

Ser His Leu Tyr His Gly His Ser His His Pro Ser His Pro Ser His

275 280 285

Pro Asn His Pro Asn His His Gly His Pro His H s His Gly Pro Pro

290 295 300

Val Met Gly His Leu Ser Met Ala Met Ser Met Gly Leu Ala Gly Met 305 310 315 320

Pro Asn Met Thr Asn Lys He Thr Lys Lys Val Ser Gin Leu Asn Arg

325 330 335

He Val Pro He Gin Glu Lys Asn Ser Ser Gly Ser Thr Ser Arg Ser

340 345 350

Met Ala Ala He Ser Leu Gly Phe He Val Met Val Thr Pro Trp Thr

355 360 365

He Gin Glu He Val Thr Ala Cys Thr Gly Ser Lys Ala Ser Val Leu

370 375 380

Tyr Lys Gly Leu Leu Cys Asp Arg Phe Leu Pro Pro Phe Leu Asp Phe 385 390 395 400

Leu Val Thr Trp Thr Ala Leu Ser Asn Ser Leu Trp Asn Pro Phe Met

405 410 415

Tyr Trp Leu Leu Asn Ser Asp Phe Arg Arg Met Ser Arg Gin Leu Met

420 425 430

Pro Asn Lys Cys Phe Pro His Glu Asp Thr Pro Glu His Lys Ser Gly

435 440 445

Cys Cys His He Asn Ala Asn Asp Phe Glu He Thr Thr Leu Pro He

450 455 460

Pro Pro Glu Pro Pro Ser Ser Arg Pro Pro Gly Gly Ala Gly Gly Gly 465 470 475 480

Gly Gly Gly Pro Ser Ser Gly Gly Pro Ser Ser Gly Gly Gly Val Ala

485 490 495

Ser Ser He Gly Gly Ser Val Leu Gly He Cys Gly Arg Ser Arg Thr

500 505 510

Asn Ser Leu Ser Arg Ser Ala Ser Gin Tyr He Arg Gly Thr Met Gly

515 520 525

Gly Gly Val His Asn His Gin Ala Thr Glu Thr Phe Ser Thr Thr Arg

530 535 540

Pro Asp He Glu Gly Leu Ser Glu Lys Tyr Trp Gly Glu He Leu Glu 545 550 555 560

Arg Thr Val Ser Ser Gly Asn Leu Asn Ala Met Gin Lys His Leu Pro

565 570 575

Pro His Leu Pro Tyr Ala His His Leu Val His Gin He His Gin Pro

580 585 590

Gin Gin His His Gin Gin Gin Thr Thr Ser Phe Ser Lys Ala Ser Asp

595 600 605

Leu Gin Leu Asn Leu Asn Leu Ser Gin Ala Ala Thr Ala Ala Glu Leu

610 615 620

Gly Lys Phe Ser Asn Ser Glu Pro Lys Leu Cys Glu His Leu Phe His 625 630 635 640

Asp Tyr Ala Glu Asp Val He Leu Ala Lys Asn Gin Leu Leu Ala Arg

645 650 655

Gin Ala Lys Cys Ser His His Pro Leu His Gin Gin Ala Lys Thr Arg

660 665 670

Leu His Ser His Thr Gly Ser Leu Arg Phe Ser Arg He Arg Ala Ala

675 680 685

Cys His Ser Pro Pro Pro Glu Lys Ser Ala Phe Pro Met Ala Glu Tyr

690 695 700

Arg Lys 705

197 <210> 154 <211> 3332 <212> DNA <213> Drosophila

<400> 154 gataaagccc aattacagaa cctaatacat acacctaaaa tgactaattg acatccattg 60 tgcgtattac ataataatga ataatttaag tgatagttgt ttgaacttac agaacacttc 120 ttagtattgc ggactcatcc catccaactg ttgactcatt tcaaattcta tttaattata 180 tttctggtcc tggcacgaac aataaattga gtttatatgt attacgcccc ttcttgtggt 240 ctcactttat gaaaaagtta attgcgtgta gttgttggct ttgctagatg gatttttatt 300 gtgccgcttt actgtctgct tttttcttca ttttccactc gcctttcatt tttcatccgc 360 cggaaagcga atcatttttt cgcacgctga gcagtgcaaa gaaagcaaac acaagcaaac 420 gagcagaatt tcatatagtt gattgcattg tctgcaggaa gatgttcgca cgatgatgca 480 ggacatgcag gactaaggac ttcgaagcga atggtgtggg ctggggcagg gatagtctca 540 tgaaatgctg atagcatgcg ctcaatattg tcagtaaata atacgcgctt gttagagcca 600 actgcatacc aactaaactg aacacagtga gaataaacat aacagaaagt tgaatttgct 660 taatatataa tttcataaat ttgtcacacc aaaattcgga tttaaattaa aagtataatt 720 atattaataa cattatttaa tataattata attatatata aaaatatatt tttatatgta 780 tgtttcattt ggttgctgaa aaccagtaac taactaatct ttgtgggcta tccaaatctc 840 ttcattgcag aaaccgcagc gtgcaacatg tgacgtcaca ggcataaagt atggagagca 900 tattaaaata tttgccattt agctggttta gcatgcattg ttgcattgac tgccacataa 960 caagtggaaa ttagcaggca gctactgtag acgaatcgaa atggaaggtg gatggtggcg 1020 aggaggagga ggaggaggac gtttgggcgg gaaagccatc atggaaggac actcgacacc 1080 aaatggggca gctgcaagcc acagaaacaa cagcacaagg accaatatcg cgaccaacgg 1140 ctgtgcccat tcgggcatcc tgttatttgt gctgacagct atgacactaa cgagcttaat 1200 aacgcccaca gagcagctgg cagtggcgcc aaatggcacc acactgcatc aactggagtc 1260 cgtggagtcc gagtcgtatc catccataaa tggcactcag aatgaaacaa tggtgaccag 1320 tgtgcgaccc cacctggacc acaggaatcg accgacgcag cagaatggca gtcactattt 1380 ggagtacgac gatgatggcc cggactgttc gtacagctac aacttcatcc tgaagctcat 1440 cacgatgatc ctgtacgcac tggtctgcat cattggactc tttggcaaca ccctggtgat 1500 ctatgtggtg atgaggttct ccaagatgca gaccgtaacc aacatataca tactgaatct 1560 ggctatcgcg gatgagtgct tcctgatcgg cattcccttc ctgctctaca caatgcaggt 1620 gggeaactgg cccttcggca actatatgtg eaaggcctae atggtgagea cctegatcac 1680 ctccttcacc tcctcgatct tcctgttgat catgtcggcg gatcgctaca tagccgtttg 1740 ccatcccata tcctcgcctc gctaccgaac gccctttgta tccaagttgg tttcggcctt 1800 cgcctggatg acatccgtgc tgctgatgct gccggttatc ctttttgcca gcaccgtgca 1860 gtcgagcaac ggcaatgtgt cctgcaacat cgagtggcca gacactcaga actcgcacac 1920 cgactccacc ttcattttgt actcgctggt cttgggattc gccactccac tgacttttat 1980 cctggtgttc tactgcctgg tgatcaggaa acttcacacc gtgggaccga agcacaagtc 2040 taaggagaag aagcgctctc acaggaaggt caccaagttg gtgctcacgg taataatata 2100 tgacatttcg attagttgtg gaactaacta ctacctgacc actcttgtgt tcagtttgat 2160 aaatattatt attacattat aaatatatat ttttttttga cattttgaat tcgactataa 2220 attaattgtt ttaaattgat atatagaaag aattttataa tatttattca atacaattta 2280 tggttttttg atttctccac aggtcataag tgcgtacata ttttgttggc ttccacactg 2340 gatttcacag gtaactaatt gtatacatta cagtctaaaa acatttatct ttgtgtactt 2400 taaaaggttt taaaaccata agctatttgc ctactattat ccttttggat tgatttttaa 2460 attattatag ctaaaaeaaa ttacgagatt tgtggaaatt gacatgaact ggacttcttt 2520 ggcagatcat ttgtagattc gctttttatt gactattttc caggtggctt tgatcagctc 2580 cgctcctcaa cgctgtgcat ctcgtctgga gctggccgtc ttcctggcct gcggatgcct 2640 cagctactcc aactcggcca tgaacccaat actgtacgcc tttttgagcg ataacttcaa 2700 gaagagcttc atgaaggcet gcacgtgtgc tgcccgcaag gatgtgaatg cccagttgca 2760 gctggagaac agtttcttcc ccaagtttgg caagggcagg caatcggagc gtcttcttgg 2820 tggcaatgga aaaggtggcg cccagcgtgg ggcattaacc aagaagaagt gcttggcgac 2880 gagaaacaac aatgctccga tggccactac aacgacgacg acaaccacca caacgggcac 2940 ggatgcagtg acctgtctcc agccgccagt acaccaggtg ccagccgaga tccaggtggg 3000 aaatccggcc accgtgctgg tggtcaatgc tgagaccaac aactgtaaac cgcccgtgct 3060 ccacacggac ttataagacc gggctccctc gatgcccctg gaaacggtgg tcttcatcgc 3120

198 gcggaggtga gaccatcagg ttgagctgga cctcgatacg gccatcgatt gccaggeaat 3180 agcgaggeag ccggaatgct tgctataggt cgcctaaaat gatattaaca ttttatacca 3240 atatggeaga gctttgeaaa aacgggtaaa cttaatccca tttttatatg atcgaatcte 3300 agcaagaaga aatttttaaa aacccgaata aa 3332

<210> 155 <211> 1332 <212> DNA <213> Drosophila

<400> 155 atggaaggtg gatggtggcg aggaggagga ggaggaggac gtttgggcgg gaaagccatc 60 atggaaggac actcgacacc aaatggggca gctgcaagcc acagaaacaa cagcacaagg 120 accaatatcg cgaccaacgg ctgtgcccat tcgggcatcc tgttatttgt gctgacagct 180 atgacactaa cgagcttaat aacgcccaca gagcagctgg cagtggcgcc aaatggcacc 240 acactgcatc aactggagtc cgtggagtcc gagtcgtatc catccataaa tggcactcag 300 aatgaaacaa tggtgaccag tgtgcgaccc cacctggacc acaggaatcg accgacgcag 360 cagaatggca gtcactattt ggagtacgac gatgatggcc cggactgttc gtacagctac 420 aacttcatcc tgaagctcat cacgatgatc ctgtacgcac tggtctgcat cattggactc 480 tttggcaaca ccctggtgat ctatgtggtg atgaggttct ccaagatgca gaccgtaacc 540 aacatataca tactgaatct ggctatcgcg gatgagtgct tcctgatcgg cattcccttc 600 ctgctctaca caatgcaggt gggeaactgg cccttcggca actatatgtg eaaggcctae 660 atggtgagea cctegatcac ctccttcacc tcctcgatct tcctgttgat catgtcggcg 720 gatcgctaca tagccgtttg ccatcccata tcctcgcctc gctaccgaac gccctttgta 780 tccaagttgg tttcggcctt cgcctggatg acatccgtgc tgctgatgct gccggttatc 840 ctttttgcca gcaccgtgca gtcgagcaac ggcaatgtgt cctgcaacat cgagtggcca 900 gacactcaga actcgcacac cgactccacc ttcattttgt actcgctggt cttgggattc 960 gccactccac tgacttttat cctggtgttc tactgcctgg tgatcaggaa acttcacacc 1020 gtgggaccga agcacaagtc taaggagaag aagcgctctc acaggaaggt caccaagttg 1080 gtgctcacgg taataatata tgacatttcg attagttgtg gaactaacta ctacctgacc 1140 actcttgtgt tcagtttgat aaatattatt attacattat aaatatatat ttttttttga 1200 cattttgaat tcgactataa attaattgtt ttaaattgat atatagaaag aattttataa 1260 tatttattca atacaattta tggttttttg atttctccac aggtcataag tgcgtacata 1320 ttttgttggc tt 1332

<210> 156 <211> 393 <212> PRT <213> Drosophila

<400> 156

Met Glu Gly Gly Trp Trp Arg Gly Gly Gly Gly Gly Gly Arg Leu Gly

1 5 10 15

Gly Lys Ala He Met Glu Gly His Ser Thr Pro Asn Gly Ala Ala Ala

20 25 30

Ser His Arg Asn Asn Ser Thr Arg Thr Asn He Ala Thr Asn Gly Cys

35 40 45

Ala His Ser Gly He Leu Leu Phe Val Leu Thr Ala Met Thr Leu Thr

50 55 60

Ser Leu He Thr Pro Thr Glu Gin Leu Ala Val Ala Pro Asn Gly Thr 65 70 75 80

Thr Leu His Gin Leu Glu Ser Val Glu Ser Glu Ser Tyr Pro Ser He

85 90 95

Asn Gly Thr Gin Asn Glu Thr Met Val Thr Ser Val Arg Pro His Leu

100 105 110

Asp His Arg Asn Arg Pro Thr Gin Gin Asn Gly Ser His Tyr Leu Glu

115 120 125

Tyr Asp Asp Asp Gly Pro Asp Cys Ser Tyr Ser Tyr Asn Phe He Leu

130 135 140

Lys Leu He Thr Met He Leu Tyr Ala Leu Val Cys He He Gly Leu

199 145 150 155 160

Phe Gly Asn Thr Leu Val He Tyr Val Val Met Arg Phe Ser Lys Met 165 170 175

Gin Thr Val Thr Asn He Tyr He Leu Asn Leu Ala He Ala Asp Glu 180 185 190

Cys Phe Leu He Gly He Pro Phe Leu Leu Tyr Thr Met Gin Val Gly 195 200 205

Asn Trp Pro Phe Gly Asn Tyr Met Cys Lys Ala Tyr Met Val Ser Thr 210 215 220

Ser He Thr Ser Phe Thr Ser Ser He Phe Leu Leu He Met Ser Ala

225 230 235 240

Asp Arg Tyr He Ala Val Cys His Pro He Ser Ser Pro Arg Tyr Arg 245 250 255

Thr Pro Phe Val Ser Lys Leu Val Ser Ala Phe Ala Trp Met Thr Ser 260 265 270

Val Leu Leu Met Leu Pro Val He Leu Phe Ala Ser Thr Val Gin Ser 275 280 285

Ser Asn Gly Asn Val Ser Cys Asn He Glu Trp Pro Asp Thr Gin Asn 290 295 300

Ser His Thr Asp Ser Thr Phe He Leu Tyr Ser Leu Val Leu Gly Phe

305 310 315 320

Ala Thr Pro Leu Thr Phe He Leu Val Phe Tyr Cys Leu Val He Arg 325 330 335

Lys Leu His Thr Val Gly Pro Lys His Lys Ser Lys Glu Lys Lys Arg 340 345 350

Ser His Arg Lys Val Thr Lys Leu Val Leu Thr Val He He Tyr Asp 355 360 365

He Ser He Ser Cys Gly Thr Asn Tyr Tyr Leu Thr Thr Leu Val Phe 370 375 380

Ser Leu He Asn He He He Thr Leu

385 390

<210> 157 <211> 5453 <212> DNA <213> Drosophila

<400> 157 gataaaagca ttacattttc gagtctgcac gatcgtatca tcagttgttt gcaggacctt 60 gagttcttca tacaaagttt tagctgctca tttttaatct gttccttgtg cagagattac 120 acttctccga aaagagccga cacgtaaatt ggaaaagggt tagtgcaact gttgttgcaa 180 ttacaattca tcacatagcc cgtagttcct cttcctgctg cacagaaaga aattggtatg 240 tggcgatcgt tgcaatgcca tgcaattcaa tgcccaattc aaaaatattt gaaatgtgta 300 aacaactcac ttgttttctt ttctgcgtgc atgtggtgct cctggccatt tgccatttcg 360 ccaggcataa tcccgacaat cggtgcgatg tgggtgatac gagtgcgaat gcgaatgcga 420 atgccaatga tatgtgtatt gtatgtatgt gcatacatat ggcgtcgtag cgtgtgggcg 480 tgatgtttgc actccggtgc agcgggacta taaataagcc gggtatttat taggggcaat 540 cataaactgc gttaacgacg ggcactctgc caacgagaat aagatccggt aaacaaaggc 600 accggtcgac gtacgtctca ttgtgcgata agctttcaat taaatctgac ccggataacg 660 gggcgcatgg gtgcgggaaa tcggaaatcg gaaacgaaaa cgaaaacgga agcggaaatc 720 gaaatcgaaa tggaaagaga tcaattttca attgcagcca atgcatgcat gtccatgggt 780 ccaatgctaa tatcgaaaga caaagctccg tgttctggag gtcgtgttcg ccatgcagac 840 tcattggttg gttgggttta actcgtacaa agtttgatgg gtttgggatt gttttttttt 900 tttttttaga acgatataac tcgatataat gctggtgcgt aaataacaac gatgttcatt 960 gttcgctttg cagcacattt actatgcggt cgatggcaaa atgaccctcc tgtcgaacat 1020 tctcgactgc ggaggctgta tttccgccca gcgcttcacc cgcctgctgc gccagtccgg 1080 ctcatcagga ccatccccat ctgcaccgac ggccggaaca tttgaatcaa aatccatgct 1140 ggagccaaca tcctcgcaca gcctggcgac cggacgcgtg ccactactgc acgatttcga 1200 tgcctcgaca acggaatcgc cgggaacgta tgtcctcgac ggtgtcgcca gggtggccca 1260

200 attggccctg gagcccaccg tcatggacgc actgcccgat tcggacacgg aacaggttct 1320 cggtaatctc aacagcagcg cgccctggaa tctaacgctt gcgtcggcag cggccaccaa 1380 tttcgagaac tgctcggcgc tttttgtcaa ttacacccta ccacaaacag gtacctaaag 1440 cctaataact tttaaatcat attgcagtat tttttttttt ttttttgttg ccgggatagg 1500 actctactgc aattggacct gggacacatt gctctgctgg ccacccactc cggctggagt 1560 ccttgcacgg atgaattgtc ctggcggctt tcatggcgta gatacgcgca gtaagtaact 1620 gaaatacact ctaaaaaaaa agcagccgaa aaagaacatg ctgagtacaa ttagcataat 1680 taatcgttga agctgtttag ctgtttagca gccacaagaa gctttatgac ttctgccggc 1740 ttattaggag tcaaaagaca tgtcctacgg tgtttatccc atccacacgg catatctggc 1800 ggtcacaatc atacggatca ttagctggga aacggttcaa gtggtgcacg gcaaacaatt 1860 acttgattcc gtattcatcg aaaggatgtc aatatttaca tgcatgactg ggggcgtcca 1920 atcaaccgca ctcccagtcg gggccgcccc tccttggctt ccatcgccgg gggctgtcca 1980 ggtgtttcat gtgcaccctc gagctccgcc agttgaacag ggtttaaaac accagccaat 2040 cgattgctta attacgatcc taaatgcttg ctctacccct ccgataaatt aaacgttctg 2100 caatggggaa ttgctattta ataaccatgg gcgatataca ctgagcgaaa agattctaag 2160 tagctgactt accacccaat attttacaaa cttaaaatgc tcttccatta tcactagtga 2220 atgtattatc tgcgcttgtg gtgcaaaatc taggcatatc gaactatatc tgttaagaaa 2280 taattattcg agtgcattgt tgagctacgg cctcatttct ccgggccgtg tctagatttt 2340 tagccccaat attttcaact ggacgaggtc ggtcgcccat tcgattggca taattgcact 2400 tgtcagtcag tgtgtcaaag ctcgattact gtcattaatc caacccaacc tccctctttt 2460 tcggttcgca gaattcgcca tccgaaagtg tgagctggat ggtcgatggg gcagcaggcc 2520 aaatgccacg gaggtgaatc cgccgggatg gacggactac gggccgtgtt acaagccgga 2580 gattatccgt ctcatgcagc agatgggcag caaggacttc gatgtgagtt gaattctttc 2640 cacactacat cataatacct gtttcagtta tagttaagag cattgcttaa atgccaacca 2700 aaatcccaaa tcaagggtat ggttttgaaa ttacctaata gggttccaag ttttttagac 2760 accctaaaaa gtgatttcaa aggcctgatt acatttgttg atagtggttt atagtagtag 2820 ttttaattcc atttcttcca actggtttgc gatatccctt aggcctacat agacattgcc 2880 aggaggactc gaaccctgga gatcgtgggc ctctgcctct ccctgttcgc ccttatagtt 2940 tccctgctga tcttctgcac atttcgctcg ctgcgaaaca atcgcaccaa gatccacaag 3000 aatcttttcg tcgccatggt gctgcaggtg atcattcgcc tgaccttgta tctcgaccaa 3060 ttccggcggg gaaacaagga ggcggccacc aacacgagtc tctctgtcat tgagaacacg 3120 gtaggcttaa tattcccgca taaggataag gtataaggct tatgttcgat attatatgtt 3180 atgttctaca gccctatttg tgcgaagcat cctatgtact tctggagtac gctcgtaccg 3240 ccatgttcat gtggatgttc atcgagggcc tttacctgca caacatggtc accgtggccg 3300 ttttccaggg cagctttccc ctcaagttct tctcgcgact cggctggtgt gtgcccattc 3360 tgatgaccac cgtgtgggcg agatgcacgg tcatgtatat ggacacctcg ctgggcgaat 3420 gcttgtggaa ctataatctc acgccctact actggatcct cgaggggcca cgactagcgg 3480 tcatactggt gggtaatatc aactgttgat cgctttaatc acctattcac ccaactgaaa 3540 acatccgcat gcagctaaac ttctgtttcc tggtgaacat tatccgagtg ctggtaatga 3600 agctgcgtca atcgcaggcc agcgatatag aacagactcg caaggcagtt agagcggcta 3660 tagtcctact accacttttg ggtataacca atctcctgca ccagctggct cctctgaaaa 3720 cggccacgaa cttcgcggtc tggtcgtatg gcacccactt tctcacctcg tttcagggat 3780 tttttatagc gctaatttac tgctttctaa atggcgaggt aagacatcaa gtcactcagt 3840 tgtccatttg cctaaaaccc tcactatttc caaccaaaat atatattttt taggttcgtg 3900 ccgtgctact aaagagtctg gccacccagc tgtcggtgcg aggtcatccg gaatgggcgc 3960 cgaaaagggc atctatgtac tcgggtgctt ataacacggc gccggatacg gatgcagtgc 4020 agcctgcagg agatccatcg gccactggaa agcggtaagc atccgctttg tgcacacccc 4080 accttgaaac tccttacatc aatttaaaac tcccagaata tcaccgccga ataaaaggct 4140 gaatggaaga aagccgagca gtgccagcat tgtgatgatt cacgagcctc aacagcgcca 4200 gcgactgatg ccccggctgc aaaacaaggc gcgggaaaag ggcaaggacc gggtggagaa 4260 gacggatgcg gaagcggagc cggatccgac catctcccac attcacagca aggaggcggg 4320 cagcgcgaga tcgcgaactc gcggctccaa gtggataatg ggcatctgct tccggggtca 4380 aaaggtacta agagtaccgt cagcgtcatc cgtgccaccc gagtcagttg tatttgagtt 4440 gtcagagcag tagaccaaaa cctagcctaa ctaatagatg tagccatagc cgtagccaaa 4500 tagccgtaga agtagccaac gccatgtagc ccaccaccac agtagccagc acccacacaa 4560 tcggaccgga aatgatccca aagataaccc agaacccgac tattcctgca tctcccatcg 4620 acccaccaag caagccagct ggaaacagca catatgtaaa ataccccaac aaaatatcgc 4680 agttcttata cccaagatca ttttgaacag aaagtaagct cattgttttg taattcaaat 4740 taaaccaata gacatttaat ttaaatagtt attttcgctt gccttcggtt cttgctccac 4800 tgtacttatg taaatacata cataccttta tttgtgtaag ccatatccaa accctttcca 4860

201 aaatctagaa atctcctatc ctttcgaaat cggctaatcc tacgaaaatt caaatttccc 4920 tacaagtttt acaaaatatt tttgatgaca ataaatttcc aatagcgtca ccttctgttc 4980 tggacacgca aatacattca aaaacactcg cacacggttc ttactcgatg aatttttcag 5040 caaaacttca gcggcatgtt cttttacttc tactattcat atttaaatat tagattgaaa 5100 tatttaagtg aattaacaca aacttgcggt aactgcgcag tgtggccagg ctttgtgagc 5160 cattagaact tattacataa cataattgaa aagtgacatt gtttaaagga actcaccttt 5220 aatcaactgt tgaacttgct gttcatcgga ttccgttatt aagttttaag atttgggttt 5280 acttgtattt acattttctt taccactttg attagcttac actttccgtt cctgagctgg 5340 tcacactgcc agctacaatc gatcacgttc actgcaactg ccttgaattt tgctagctgc 5400 gctttgttgt gcaacaaaaa ctttgccaca atcgatattt aactaatggg gtc 5453

<210> 158 <211> 1902 <212> DNA <213> Drosophila

<400> 158 atgaccctcc tgtcgaacat tctcgactgc ggaggctgta tttccgccca gcgcttcacc 60 cgcctgctgc gccagtccgg ctcatcagga ccatccccat ctgcaccgac ggccggaaca 120 tttgaatcaa aatccatgct ggagccaaca tcctcgcaca gcctggcgac cggacgcgtg 180 ccactactgc acgatttcga tgcctcgaca acggaatcgc cgggaacgta tgtcctcgac 240 ggtgtcgcca gggtggccca attggccctg gagcccaccg tcatggacgc actgcccgat 300 tcggacacgg aacaggttct cggactctac tgcaattgga cctgggacac attgctctgc 360 tggccaccca ctccggctgg agtccttgca cggatgaatt gtcctggcgg ctttcatggc 420 gtagatacgc gcaaattcgc catccgaaag tgtgagctgg atggtcgatg gggcagcagg 480 ccaaatgcca cggaggtgaa tccgccggga tggacggact acgggccgtg ttacaagccg 540 gagattatcc gtctcatgca gcagatgggc agcaaggact tcgatgccta catagacatt 600 gccaggagga ctcgaaccct ggagatcgtg ggcctctgcc tctccctgtt cgcccttata 660 gtttccctgc tgatcttctg cacatttcgc tcgctgcgaa acaatcgcac caagatccac 720 aagaatcttt tcgtcgccat ggtgctgcag gtgatcattc gcctgacctt gtatctcgac 780 caattccggc ggggaaacaa ggaggcggcc accaacacga gtctctctgt cattgagaac 840 acgccctatt tgtgcgaagc atcctatgta cttctggagt acgctcgtac cgccatgttc 900 atgtggatgt tcatcgaggg cctttacctg cacaacatgg tcaccgtggc cgttttccag 960 ggcagctttc ccctcaagtt cttctcgcga ctcggctggt gtgtgcccat tctgatgacc 1020 accgtgtggg cgagatgcac ggtcatgtat atggacacct cgctgggcga atgcttgtgg 1080 aactataatc tcacgcccta ctactggatc ctcgaggggc cacgactagc ggtcatactg 1140 ctaaacttct gtttcctggt gaacattatc cgagtgctgg taatgaagct gcgtcaatcg 1200 caggccagcg atatagaaca gactcgcaag gcagttagag cggctatagt cctactacca 1260 cttttgggta taaccaatct cctgcaccag ctggctcctc tgaaaacggc cacgaacttc 1320 gcggtctggt cgtatggcac ccactttctc acctcgtttc agggattttt tatagcgcta 1380 atttactgct ttctaaatgg cgaggttcgt gccgtgctac taaagagtct ggccacccag 1440 ctgtcggtgc gaggtcatcc ggaatgggcg ccgaaaaggg catctatgta ctcgggtgct 1500 tataacacgg cgccggatac ggatgcagtg cagcctgcag gagatccatc ggccactgga 1560 aagcgaatat caccgccgaa taaaaggctg aatggaagaa agccgagcag tgccagcatt 1620 gtgatgattc acgagcctca acagcgccag cgactgatgc cccggctgca aaacaaggcg 1680 cgggaaaagg gcaaggaccg ggtggagaag acggatgcgg aagcggagcc ggatccgacc 1740 atctcccaca ttcacagcaa ggaggcgggc agcgcgagat cgcgaactcg cggctccaag 1800 tggataatgg gcatctgctt ccggggtcaa aaggtactaa gagtaccgtc agcgtcatcc 1860 gtgccacccg agtcagttgt atttgagttg tcagagcagt ag 1902

<210> 159 <211> 633 <212> PRT <213> Drosophila

<400> 159

Met Thr Leu Leu Ser Asn He Leu Asp Cys Gly Gly Cys He Ser Ala 1 5 10 15

202 Gin Arg Phe Thr Arg Leu Leu Arg Gin Ser Gly Ser Ser Gly Pro Ser

20 25 30

Pro Ser Ala Pro Thr Ala Gly Thr Phe Glu Ser Lys Ser Met Leu Glu

35 40 45

Pro Thr Ser Ser His Ser Leu Ala Thr Gly Arg Val Pro Leu Leu His

50 55 60

Asp Phe Asp Ala Ser Thr Thr Glu Ser Pro Gly Thr Tyr Val Leu Asp 65 70 75 80

Gly Val Ala Arg Val Ala Gin Leu Ala Leu Glu Pro Thr Val Met Asp

85 90 95

Ala Leu Pro Asp Ser Asp Thr Glu Gin Val Leu Gly Leu Tyr Cys Asn

100 105 110

Trp Thr Trp Asp Thr Leu Leu Cys Trp Pro Pro Thr Pro Ala Gly Val

115 120 125

Leu Ala Arg Met Asn Cys Pro Gly Gly Phe His Gly Val Asp Thr Arg

130 135 140

Lys Phe Ala He Arg Lys Cys Glu Leu Asp Gly Arg Trp Gly Ser Arg 145 150 155 160

Pro Asn Ala Thr Glu Val Asn Pro Pro Gly Trp Thr Asp Tyr Gly Pro

165 170 175

Cys Tyr Lys Pro Glu He He Arg Leu Met Gin Gin Met Gly Ser Lys

180 185 190

Asp Phe Asp Ala Tyr He Asp He Ala Arg Arg Thr Arg Thr Leu Glu

195 200 205

He Val Gly Leu Cys Leu Ser Leu Phe Ala Leu He Val Ser Leu Leu

210 215 220

He Phe Cys Thr Phe Arg Ser Leu Arg Asn Asn Arg Thr Lys He His 225 230 235 240

Lys Asn Leu Phe Val Ala Met Val Leu Gin Val He He Arg Leu Thr

245 250 255

Leu Tyr Leu Asp Gin Phe Arg Arg Gly Asn Lys Glu Ala Ala Thr Asn

260 265 270

Thr Ser Leu Ser Val He Glu Asn Thr Pro Tyr Leu Cys Glu Ala Ser

275 280 285

Tyr Val Leu Leu Glu Tyr Ala Arg Thr Ala Met Phe Met Trp Met Phe

290 295 300

He Glu Gly Leu Tyr Leu His Asn Met Val Thr Val Ala Val Phe Gin 305 310 315 320

Gly Ser Phe Pro Leu Lys Phe Phe Ser Arg Leu Gly Trp Cys Val Pro

325 330 335

He Leu Met Thr Thr Val Trp Ala Arg Cys Thr Val Met Tyr Met Asp

340 345 350

Thr Ser Leu Gly Glu Cys Leu Trp Asn Tyr Asn Leu Thr Pro Tyr Tyr

355 360 365

Trp He Leu Glu Gly Pro Arg Leu Ala Val He Leu Leu Asn Phe Cys

370 375 380

Phe Leu Val Asn He He Arg Val Leu Val Met Lys Leu Arg Gin Ser 385 390 395 400

Gin Ala Ser Asp He Glu Gin Thr Arg Lys Ala Val Arg Ala Ala He

405 410 415

Val Leu Leu Pro Leu Leu Gly He Thr Asn Leu Leu His Gin Leu Ala

420 425 430

Pro Leu Lys Thr Ala Thr Asn Phe Ala Val Trp Ser Tyr Gly Thr His

435 440 445

Phe Leu Thr Ser Phe Gin Gly Phe Phe He Ala Leu He Tyr Cys Phe

450 455 460

Leu Asn Gly Glu Val Arg Ala Val Leu Leu Lys Ser Leu Ala Thr Gin 465 470 475 480

Leu Ser Val Arg Gly His Pro Glu Trp Ala Pro Lys Arg Ala Ser Met 485 490 495

203 Tyr Ser Gly Ala Tyr Asn Thr Ala Pro Asp Thr Asp Ala Val Gin Pro

500 505 510

Ala Gly Asp Pro Ser Ala Thr Gly Lys Arg He Ser Pro Pro Asn Lys

515 520 525

Arg Leu Asn Gly Arg Lys Pro Ser Ser Ala Ser He Val Met He His

530 535 540

Glu Pro Gin Gin Arg Gin Arg Leu Met Pro Arg Leu Gin Asn Lys Ala 545 550 555 560

Arg Glu Lys Gly Lys Asp Arg Val Glu Lys Thr Asp Ala Glu Ala Glu

565 570 575

Pro Asp Pro Thr He Ser His He His Ser Lys Glu Ala Gly Ser Ala

580 585 590

Arg Ser Arg Thr Arg Gly Ser Lys Trp He Met Gly He Cys Phe Arg

595 600 605

Gly Gin Lys Val Leu Arg Val Pro Ser Ala Ser Ser Val Pro Pro Glu

610 615 620

Ser Val Val Phe Glu Leu Ser Glu Gin 625 630

<210> 160 <211> 4385 <212> DNA <213> Drosophila

<400> 160 gcttacaaaa ccaaaaacca gattttgtgc ttcaaatcac aaacataacg aaagaaatat 60 gaatggaaaa cagaggattt tatcatcact tgaaggctga caaaacattt ggcacaattt 120 acattgtccg gcgatttatt gccgtctaga gacaaaaaac actccggaaa attgtcactt 180 tgcttgcagt aagaaagtaa cttttaatta gaggttactg cagctatgca gctgctactg 240 cggttgctac taaaagcaaa agtgaagata tatcctttga atctcagcac aaattgcatt 300 ctccgtattt tctcatttgt ctaatggagt tatgtcacca agaaatgcgt gagtgttaca 360 ctcacaaaat atgttctatt cccaagaaat tcttctctgt aagtaagtgt aaaagtgtgt 420 acactaactc tgtttgtatt aaagacaaat gcataagaat gccttaaatt cgtctacgtg 480 taacatgtaa gccagaattt ttgttgcatg ttacacgttt tcccacaaat tgccaaaatc 540 atctgcttct gccggcccac tagtcgtatg cgtattattg attacggaac gaggccttgt 600 tttcttacca tttcggacaa atggtaatga catttcattg ttgattcgtt tgaaatcgta 660 cctttgacct gccctgaact tggacatcgt tctttgcatg tggcatgcaa tgccattgta 720 tttggggaat ttcgaagctt aaattctggt aaaattcaaa ccacaacact gaattcgttt 780 tttattcacc taacgcctga tgtttatttg caggtagcag gtagcacttt cgccacgcag 840 cctgcatatt tgagtgttgg aatttccgaa aagggaattt aaatgaaacg ccagaggagc 900 agcggggcgc actgagttgg cagccggaca ccgcggtcaa tcaaacggag tccttgcagg 960 acatcccacc accgactacc atctggcctt cattgacacc atggtcacga acatgtcgca 1020 gccgcattat tgcggcaccg gcatcgatga tttccacaca aagtgagtag aacgaggacg 1080 tggacttagg cctgggcaca tagcccctgg gtatgtctgc atattaatta gttttttaag 1140 tgtaatttac ataatgattt gccagccggg gggcgcataa tgaaatcatg tgtgtaattg 1200 cctacggccg tggtggcaaa aaggctaacg aagtgtgcct aatgtggatg ggcccctttc 1260 ggattaaact gaacaaatac tcgcataaat ccataaagca gatgttaaag gtcggagatg 1320 aacattttga aaaatatatt gagttcaatc taaccaacca tgttgtttat tcggtttctt 1380 tctctacata agctctaatt actttaagaa tttaatcata cccaattttg tgctcaagtg 1440 aaactggttt taaatattta tcccaatttt ttttgtcttt ctccccaaca gctacaaata 1500 ctttcacggt tacttctcgc tgattgtctg tatcctggga accattgcga ataccctaaa 1560 tatcatagtg ctgacccgac gggagatgcg ctcccccaca aatgccatac tcacgggtct 1620 ggctgtcgcc gatctggctg tgatgctgga atacataccc tatacggtgc acgactatat 1680 cctcagtgta aggctgccgc gagaggagca gctcagctac agctgggcgt gcttcatcaa 1740 gtttcactcg gtatttcccc aggtgctgca caccatctcc atttggctaa cggtgacgct 1800 ggcagtttgg cggtacatag cggtaagcta tccgcaaagg aatcgcatct ggtgtggaat 1860 gcgaactact ctgatcacca tagccacggc ctatgttgtc tgtgtcctgg tagtgtcacc 1920 ttggctgtac ctagtcacag ccattgccaa gttcctagag actttggatg ccaatggcaa 1980 gacgattgcc tcagtgccat tgagtcaata cattctggac tacaatcggc aggatgaggt 2040

204 gaccatgcag gtcatgtcga gtacaacgcc agatgtttcc tgggcgatac caagtgattc 2100 ggccaatgga actgcagtta gcttgctaag tctaaccaca gtgatacccc taaccacatt 2160 aagcactgga gtaaccacat cctcgtcgtt gggtgagcgc aatgtgactg tctataagct 2220 gtatcacagc gcactggcgc tgcgtgatcg gcagttcagg aatgcgacct tccttatata 2280 cagtgtcctg atcaagctga taccctgctt cgcactgacc attctgtctg tgcggctcat 2340 cggtgctctg ttggaggcca aaaggaggag gaagatcctg gcctgtcatg cagccaacga 2400 tatgcagcca attgtcaatg gaaaggtggt gattccgacg caacccaaga gctgtaaact 2460 gctggagaag gagaagcaga ccgatcgcac cacgaggatg cttctggcgg tactgctgct 2520 cttcctggtc accgagtttc cacagggcat tatgggtctg ctgaatgtgc tcctgggcga 2580 tgccttcttt ctgcaatgtt acctaaagct gagtaagtat tttaggatta agacacccac 2640 tcctccgctg tctgtaaccc gtaattgctt tattggctat gataattgac tgaatttatg 2700 gttggtgttt aggtgggccc agtttggcac attcatcaat catacgcacc gttggctgcc 2760 ataattgcac cacaaatttg aggcttcaat gaaggcctgg cattgacgtg ttcaataagt 2820 gtacattttg tttatctcgt acacccaaaa taaagtagtc ttacatttaa aacttcgcag 2880 atactattaa attgagagat ttttttcttt aatttgagta aaagtataaa attgaaaaaa 2940 aaatatttta aacatttaat atgtagtttt tagctagcat atgttttttc aagtgtagga 3000 ggtataaaat ctaatcgccc ttgaacttta tgaaagccct gcccatagat ggcgtgttgg 3060 tggaacccga catttatggc atttcgattt tttcgtttca ggtgacctta tggacatctt 3120 ggcgcttatt aattcgagca tcaacttcat cctgtactgt tcgatgagcc gccagttccg 3180 gagcacgttc gcgctcctct tccgtccgcg ctggctggac aaatggctgc cgctgtcgca 3240 gcacgacggc gaagggaggg tgggcggaag tggcggcctg ggcggctacg gcggatatgg 3300 acggcagcgg ttgctgcaca cggatgccgt tagcaagagc atggccatcg atctcgggct 3360 gacgacccaa gtgacaaatg tgtagcagga gagcagcggc cgggcggcga tgtcagccgc 3420 agccggcgga gcagctgcat cggtggctct ggccctggca gccactgatg ttgatggatg 3480 tccgcctgcc accgatgctg ctgtttccac taacgacatc agcctggtcg agaagctaca 3540 tttgcagccc agtccaaggg ggactgcgat atccagtggc cagcatcgaa ggcggcgcag 3600 tgggagtggc accaagtgca tctggcccac gacggactgg ctgagaaagc tgcgtaacca 3660 gaaggctaga gaaacggagc aatcctccga acaggacata gagctgggca agagctccat 3720 caacaggcgc agcagtgttc ttctaatggt attactaagc agctccgatg aggttaaagc 3780 caaggcggtt ttggtcagtg aacagccgcc gagtccagcg gacgaggatg tggaagacgc 3840 cattgacgcc ctctggctgt gagacgaccc ctcacttcca ttttgtacgc cctgtaaatt 3900 atccaagtac ccactaatat ttaactaccg tgtacagacc aattattgag acaaattgtt 3960 atgcgctgat tccattattt tcccgccagt gttgtcttgg cgaatcgaga gcccctttcg 4020 ctgagacttt gctttgctgg aaaatgagtg gattttcctt gaaaggactc cctggaagca 4080 gcctgcaaca ttttgtgacc acatttgata agtgatatac ttgactaagt ttcccccctt 4140 aatagttgtg taagtgctaa gcgcgtctct agatataaac gaattagtca tagtctaact 4200 attaattaag atatattgat gaaataattc ggaagctaag agattaaatt tctttttata 4260 ttgaataaat gttttttcga agtaaacttg attcaattca cttattgtaa gtgttattgc 4320 gacactttgt tttaattaaa cggaatttat attgaacttt gataaacgaa tgcttttgaa 4380 tgcat 4385

<210> 161 <211> 1389 <212> DNA <213> Drosophila

<400> 161 atggtcacga acatgtcgca gccgcattat tgcggcaccg gcatcgatga tttccacaca 60 aactacaaat actttcacgg ttacttctcg ctgattgtct gtatcctggg aaccattgcg 120 aataccctaa atatcatagt gctgacccga cgggagatgc gctcccccac aaatgccata 180 ctcacgggtc tggctgtcgc cgatctggct gtgatgctgg aatacatacc ctatacggtg 240 cacgactata tcctcagtgt aaggctgccg cgagaggagc agctcagcta cagctgggcg 300 tgcttcatca agtttcactc ggtatttccc caggtgctgc acaccatctc catttggcta 360 acggtgacgc tggcagtttg gcggtacata gcggtaagct atccgcaaag gaatcgcatc 420 tggtgtggaa tgcgaactac tctgatcacc atagccacgg cctatgttgt ctgtgtcctg 480 gtagtgtcac cttggctgta cctagtcaca gccattgcca agttcctaga gactttggat 540 gccaatggca agacgattgc ctcagtgcca ttgagtcaat acattctgga ctacaatcgg 600 caggatgagg tgaccatgca ggtcatgtcg agtacaacgc cagatgtttc ctgggcgata 660 ccaataacca catcctcgtc gttgggtgag cgcaatgtga ctgtctataa gctgtatcac 720 agcgcactgg cgctgcgtga tcggcagttc aggaatgcga ccttccttat atacagtgtc 780

205 ctgatcaagc tgataccctg cttcgcactg accattctgt ctgtgcggct catcggtgct 840 ctgttggagg ccaaaaggag gaggaagatc ctggcctgtc atgcagccaa cgatatgcag 900 ccaattgtca atggaaaggt ggtgattccg acgcaaccca agagctgtaa actgctggag 960 aaggagaagc agaccgatcg caccacgagg atgcttctgg cggtactgct gctcttcctg 1020 gtcaccgagt ttccacaggg cattatgggt ctgctgaatg tgctcctggg cgatgccttc 1080 tttctgcaat gttacctaaa gctgagtgac cttatggaca tcttggcgct tattaattcg 1140 agcatcaact tcatcctgta ctgttcgatg agccgccagt tccggagcac gttcgcgctc 1200 ctcttccgtc cgcgctggct ggacaaatgg ctgccgctgt cgcagcacga cggcgaaggg 1260 agggtgggcg gaagtggcgg cctgggcggc tacggcggat atggacggca gcggttgctg 1320 cacacggatg ccgttagcaa gagcatggcc atcgatctcg ggctgacgac ccaagtgaca 1380 aatgtgtag 1389

<210> 162 <211> 462 <212> PRT <213> Drosophila

<400> 162

Met Val Thr Asn Met Ser Gin Pro His Tyr Cys Gly Thr Gly He Asp

1 5 10 15

Asp Phe His Thr Asn Tyr Lys Tyr Phe His Gly Tyr Phe Ser Leu He

20 25 30

Val Cys He Leu Gly Thr He Ala Asn Thr Leu Asn He He Val Leu

35 40 45

Thr Arg Arg Glu Met Arg Ser Pro Thr Asn Ala He Leu Thr Gly Leu

50 55 60

Ala Val Ala Asp Leu Ala Val Met Leu Glu Tyr He Pro Tyr Thr Val 65 70 75 80

His Asp Tyr He Leu Ser Val Arg Leu Pro Arg Glu Glu Gin Leu Ser

85 90 95

Tyr Ser Trp Ala Cys Phe He Lys Phe His Ser Val Phe Pro Gin Val

100 105 110

Leu His Thr He Ser He Trp Leu Thr Val Thr Leu Ala Val Trp Arg

115 120 125

Tyr He Ala Val Ser Tyr Pro Gin Arg Asn Arg He Trp Cys Gly Met

130 135 140

Arg Thr Thr Leu He Thr He Ala Thr Ala Tyr Val Val Cys Val Leu 145 150 155 160

Val Val Ser Pro Trp Leu Tyr Leu Val Thr Ala He Ala Lys Phe Leu

165 170 175

Glu Thr Leu Asp Ala Asn Gly Lys Thr He Ala Ser Val Pro Leu Ser

180 185 190

Gin Tyr He Leu Asp Tyr Asn Arg Gin Asp Glu Val Thr Met Gin Val

195 200 205

Met Ser Ser Thr Thr Pro Asp Val Ser Trp Ala He Pro He Thr Thr

210 215 220

Ser Ser Ser Leu Gly Glu Arg Asn Val Thr Val Tyr Lys Leu Tyr His 225 230 235 240

Ser Ala Leu Ala Leu Arg Asp Arg Gin Phe Arg Asn Ala Thr Phe Leu

245 250 255

He Tyr Ser Val Leu He Lys Leu He Pro Cys Phe Ala Leu Thr He

260 265 270

Leu Ser Val Arg Leu He Gly Ala Leu Leu Glu Ala Lys Arg Arg Arg

275 280 285

Lys He Leu Ala Cys His Ala Ala Asn Asp Met Gin Pro He Val Asn

290 295 300

Gly Lys Val Val He Pro Thr Gin Pro Lys Ser Cys Lys Leu Leu Glu 305 310 315 320

Lys Glu Lys Gin Thr Asp Arg Thr Thr Arg Met Leu Leu Ala Val Leu 325 330 335

206 Leu Leu Phe Leu Val Thr Glu Phe Pro Gin Gly He Met Gly Leu Leu

340 345 350

Asn Val Leu Leu Gly Asp Ala Phe Phe Leu Gin Cys Tyr Leu Lys Leu

355 360 365

Ser Asp Leu Met Asp He Leu Ala Leu He Asn Ser Ser He Asn Phe

370 375 380

He Leu Tyr Cys Ser Met Ser Arg Gin Phe Arg Ser Thr Phe Ala Leu 385 390 395 400

Leu Phe Arg Pro Arg Trp Leu Asp Lys Trp Leu Pro Leu Ser Gin His

405 410 415

Asp Gly Glu Gly Arg Val Gly Gly Ser Gly Gly Leu Gly Gly Tyr Gly

420 425 430

Gly Tyr Gly Arg Gin Arg Leu Leu His Thr Asp Ala Val Ser Lys Ser

435 440 445

Met Ala He Asp Leu Gly Leu Thr Thr Gin Val Thr Asn Val 450 455 460

<210> 163 <211> 4214 <212> DNA <213> Drosophila

<400> 163 ataattctta tgaaaaatat aaaaatgggc tgattaaaat gattggtatt atggaaatta 60 ttattgaaaa aatatgaaat ttacatttta aaaagtgtta ttcgcgttat tactcagttt 120 gtaaatagcg ggcatcaatt gtgcatagtt tgaaggtaag ttgcccaata aatggcgcaa 180 agctcgtaac cgcgaattat atatgtatgt acatatacga taaaaataaa gtgtggcctt 240 tgcttggata aaaaaatcgt ccgagtcgcc ggatatccat attatcgctt tcagaaaatt 300 cgatatcatc gataggtgtt tccctttcaa aagtcttcgt ccgatttggt ccgtttgact 360 acttttatct ggtgcatacc cgatttgact gcttggacgg agtgggatgt gtgaatgaac 420 actaaaacgc ttgaaacttg agaaattagg gaagtagacg ggtagcgtca gtttgtttga 480 gaagattaac aagcccacaa actgcacaaa acttgcaagg ccattttatt atttgtctat 540 ccattttcga tcgatatggc aacaacattt aagccatgcc cactctaatg cgtcaataaa 600 tgcgactaat ccaggcgggc ccccaagtta acttggccct cctcatcgag tcaagcgctt 660 ccttcgaaga atgatttacc gttgatcata ccgggaagcc ttttttggtc ttcaggggag 720 gtagagacta catgtggtat taagatgaaa aaactaaatg cgtacatcaa atcaaaagta 780 ttcttattaa tccaagtgaa ttataatatt tattttggca ccttgtaaat gtgacaagtg 840 attagaaatg tggttcttct taaagatata aatgtacatc ataatatgct agagtactga 900 ggcactatta tttatatact ctcccgtgtg cgacagacta aatgattcat aatgaatatg 960 aataccagag ttcacagatg agcaataatc tcagttcctg ttaaagtgat gtcactgtcg 1020 gcttgtaggg agagtctgtg aaggaaaata tcaatgttaa aagaagataa attaaagcaa 1080 taagatgaac accaacctga agattttaga tcgcctttct catcgaactt gtatacgcga 1140 gcattaataa tactcagatc tgtctgactt gattccctgt aaaaaaaaaa aatgggcaat 1200 taaaatatta tagcttctat tcgaatattt caacttacac attaatggcc caccaggatt 1260 tgacgtgcaa attcttgcca aggagcagaa taaaaccagc tatggccagg cccagaatgc 1320 aaattccact ccagaagtca atgatgaaga aatgctctct cactctggcc attatataca 1380 cgactatttc tcggatccag accgcaaaca cgcccactat gtaagcgcta aaggcataga 1440 aactgcagga atataaaaga taaataggtc tataataaaa acagctttta ggaaatctta 1500 ctgcgtcttg acgattttca gttgagtgcc caatatgtac tgagtatctg gtggcagttc 1560 gtagatggaa aagtacgcct tgagacagca tacaatgctg aatatcagga ggagtgcaat 1620 gggtccgtag tagtagatca aaatacccca ggtgcgaact gaaaatgcat agataattcg 1680 aaattagact ttgttgtact ttcttattca acctaccatc gaaccagcag taatcttctc 1740 ccatgcctgg cttgaagtgc ttgggcagct tggagtcctg ggctaaggag accaaaaacc 180 ^■00 gaagaccaat caccgccaga actgccagag caagggacaa tcgacggacg gagctcctga 1860 cagccttttg tttaaatttg agcagaaagt caagactgca aatggccaga aagacgaagg 1920 agagcatgat gcagaagtag gccagaaatc cttttgggat gcatagaaca aaataagtta 1980 tccagttgaa gtagacaaaa ttactcaacc tatgtttctg caagccacat gcgagagctt 2040 catgggattc ttcaaggcca agtagaccaa cagggagtaa ccaacgatca tggacagcaa 2100 gtagtagatg attaactggc catagtggct tttacgggca tctctcacag atccaagtag 2160

207 ggagagtatg aaaatgttta taatgatggc tataatactg cctagaaggg aacaagagtt 2220 agaatctctt cgaaagtatt caaacaacac gactcacaaa tggcgtaaat ccaaacccgg 2280 taccccgttt gaaagcgttc gcagttgagc ggagtgagct cccactgctc cggattgtgc 2340 tccaacgggc taaagcaata ctcatccgtt gaccacagac gattgtcccg ccgcagagtt 2400 ccattctcga agaggtccca ttgccagaag ttatcgtgct ttttgtccac gaatttgttc 2460 cggcaaccca gctctgtgcg caccacaaaa cgatcgcgta tgcgtacttg atccacagtc 2520 ctgttagcgt aggtgagctc cacgtgagtg gactcgcgga cttggtgtgg cattgtgcag 2580 ttccagtgct tggcatcaaa gacgaggttc tccggacaac agaaactgat gcagggcttc 2640 agcagacaga cgcagccgcg cagatgtttc ttggcccggt actccactcc atcgatcacc 2700 ttgaaggagt actccgccat cagatgcggt gggaccacta ctccagcgta tgagtaggag 2760 ccatccttca tccgcagtcc atccgtaatg ttgaccgtgt gggcgtaggc acagggatgg 2820 tttatactgg cgatctccac tgactttgcg cccacggaga gccaaataat taaaagaatt 2880 atcaatggcg agaccatggc taactgatcc acgcttgttg gatttttggt cgattcgttc 2940 gtcggcctga cgtcacacgc tgttcagctc gataattaag taaacaaata tgagaagcga 3000 tcgccgttcg ctttgagcaa tgcacgcaca ctcgccgagt cagaaatctg caccaacaac 3060 aatggaaacc caaaattgac aacgaatgtg acgcgggtct aaaaacggct gcgattgcga 3120 caacgacacc gacaacacca aaaagaacaa ccataaacat aaaagtttgg tggagagtct 3180 ctcctagcta gtcgtcttgc ctctctctaa acgacaaacc ggcaaccgca acggagctcc 3240 atgctggcca agaataaaaa acagactaac tgattagccg ttcccaaaac cagacgcgac 3300 cacaagcagc tggcaaaaag agcgattggg aagactcaca acccgtcccg cccctcctcc 3360 tagaaaccgg cgtggaatct caaccagctc ggaacttgca catgcatacc ttaagttgta 3420 agcatataat ccattcgagc catttccaga cttatcttga gatagatata aaagttaaga 3480 atattagatt agattatttc catccatttt ctataattta ttgcctttgc gaccgtaaag 3540 aaaatccaat ttttaaccga caatccaaat ggcccaaacg aatttaccac agctttagtt 3600 tttaaatatt taggtgcatt tccaggctat acaaagtttg tctacatgta ggtgtgtgac 3660 ctggcttgat atcgtttacg gtcttcaaga atattcgaaa agattcgttg atttttgaca 3720 aacagatccg ctgaggaaaa aacgacgttc attttatctt tggctttatt aagcttgaaa 3780 tacaattata attcttgtat tgtgttttac attagttcag agataatgca gatatggaga 3840 atggtacatt tatgcaaaga gggtatacaa tcaacaccaa tctcgttttt aacaaggcac 3900 atctgtatgt tacgtatttt tgctggatgt ttaccttgga cttaggctaa tggagaatta 3960 caaatttgat ctctcagctg ggttcggaga accttacaat tttgcttgca taaacagtag 4020 atatggctct gcataaattt cttatacaac taatcaggtt gttcgtggtc acatggcatt 4080 aaaaaatgaa agagaattgg gcggggtggg gtgggtaagg gttttcgtgg tagttctggg 4140 ggatagggac tttctcttat agtagtgtct ttcataaagt tctatccgta tgtggatgct 4200 acttcgcgaa ttta 4214

<210> 164 <211> 1859 <212> DNA <213> Drosophila

<400> 164 tcgtttagag agaggcaaga cgactagcta ggagagactc tccaccaaac ttttatgttt 60 atggttgttc tttttggtgt tgtcggtgtc gttgtcgcaa tcgcagccgt ttttagaccc 120 gcgtcacatt cgttgtcaat tttgggtttc cattgttgtt ggtgcagatt tctgactcgg 180 cgagtgtgcg tgcattgctc aaagcgaacg gcgatcgctt ctcatatttg tttacttaat 240 tatcgagctg aacagcgtgt gacgtcaggc cgacgaacga atcgaccaaa aatccaacaa 300 gcgtggatca gttagccatg gtctcgccat tgataattct tttaattatt tggctctccg 360 tgggcgcaaa gtcagtggag atcgccagta taaaccatcc ctgtgcctac gcccacacgg 420 tcaacattac ggatggactg cggatgaagg atggctccta ctcatacgct ggagtagtgg 480 tcccaccgca tctgatggcg gagtactcct tcaaggtgat cgatggagtg gagtaccggg 540 ccaagaaaca tctgcgcggc tgcgtctgtc tgctgaagcc ctgcatcagt ttctgttgtc 600 cggagaacct cgtctttgat gccaagcact ggaactgcac aatgccacac caagtccgcg 660 agtccactca cgtggagctc acctacgcta acaggactgt ggatcaagta cgcatacgcg 720 atcgttttgt ggtgcgcaca gagctgggtt gccggaacaa attcgtggac aaaaagcacg 780 ataacttctg gcaatgggac ctcttcgaga atggaactct gcggcgggac aatcgtctgt 840 ggtcaacgga tgagtattgc tttagcccgt tggagcacaa tccggagcag tgggagctca 900 ctccgctcaa ctgcgaacgc tttcaaacgg ggtaccgggt ttggatttac gccatttgca 960 gtattatagc catcattata aacattttca tactctccct acttggatct gtgagagatg 1020 cccgtaaaag ccactatggc cagttaatca tctactactt gctgtccatg atcgttggtt 1080

208 actccctgtt ggtctacttg gccttgaaga atcccatgaa gctctcgcat gtggcttgca 1140 gaaacatagg atttctggcc tacttctgca tcatgctctc cttcgtcttt ctggccattt 1200 gcagtcttga ctttctgctc aaatttaaac aaaaggctgt caggagctcc gtccgtcgat 1260 tgtcccttgc tctggcagtt ctggcggtga ttggtcttcg gtttttggtc tccttagccc 1320 aggactccaa gctgcccaag cacttcaagc caggcatggg agaagattac tgctggttcg 1380 atgttcgcac ctggggtatt ttgatctact actacggacc cattgcactc ctcctgatat 1440 tcagcattgt atgctgtctc aaggcgtact tttccatcta cgaactgcca ccagatactc 1500 agtacatatt gggcactcaa ctgaaaatcg tcaagacgca tttctatgcc tttagcgctt 1560 acatagtggg cgtgtttgcg gtctggatcc gagaaatagt cgtgtatata atggccagag 1620 tgagagagca tttcttcatc attgacttct ggagtggaat ttgcattctg ggcctggcca 1680 tagctggttt tattctgctc cttggcaaga atttgcacgt caaatcctgg tgggccatta 1740 atgtggaatc aagtcagaca gatctgagta ttattaatgc tcgcgtatac aagttcgatg 1800 agaaaggcga tctaaaatct tcagactctc cctacaagcc gacagtgaca tcactttaa 1859

<210> 165 <211> 513 <212> PRT <213> Drosophila

<400> 165

Met Val Ser Pro Leu He He Leu Leu He He Trp Leu Ser Val Gly

1 5 10 15

Ala Lys Ser Val Glu He Ala Ser He Asn His Pro Cys Ala Tyr Ala 20 25 30

His Thr Val Asn He Thr Asp Gly Leu Arg Met Lys Asp Gly Ser Tyr 35 40 45

Ser Tyr Ala Gly Val Val Val Pro Pro His Leu Met Ala Glu Tyr Ser 50 55 60

Phe Lys Val He Asp Gly Val Glu Tyr Arg Ala Lys Lys His Leu Arg

65 70 75 80

Gly Cys Val Cys Leu Leu Lys Pro Cys He Ser Phe Cys Cys Pro Glu 85 90 95

Asn Leu Val Phe Asp Ala Lys His Trp Asn Cys Thr Met Pro His Gin 100 105 110

Val Arg Glu Ser Thr His Val Glu Leu Thr Tyr Ala Asn Arg Thr Val 115 120 125

Asp Gin Val Arg He Arg Asp Arg Phe Val Val Arg Thr Glu Leu Gly 130 135 140

Cys Arg Asn Lys Phe Val Asp Lys Lys His Asp Asn Phe Trp Gin Trp

145 150 155 160

Asp Leu Phe Glu Asn Gly Thr Leu Arg Arg Asp Asn Arg Leu Trp Ser 165 170 175

Thr Asp Glu Tyr Cys Phe Ser Pro Leu Glu His Asn Pro Glu Gin Trp 180 185 190

Glu Leu Thr Pro Leu Asn Cys Glu Arg Phe Gin Thr Gly Tyr Arg Val 195 200 205

Trp He Tyr Ala He Cys Ser He He Ala He He He Asn He Phe 210 215 220

He Leu Ser Leu Leu Gly Ser Val Arg Asp Ala Arg Lys Ser His Tyr

225 230 235 240

Gly Gin Leu He He Tyr Tyr Leu Leu Ser Met He Val Gly Tyr Ser 245 250 255

Leu Leu Val Tyr Leu Ala Leu Lys Asn Pro Met Lys Leu Ser His Val 260 265 270

Ala Cys Arg Asn He Gly Phe Leu Ala Tyr Phe Cys He Met Leu Ser 275 280 285

Phe Val Phe Leu Ala He Cys Ser Leu Asp Phe Leu Leu Lys Phe Lys 290 295 300

Gin Lys Ala Val Arg Ser Ser Val Arg Arg Leu Ser Leu Ala Leu Ala

305 310 315 320

209 Val Leu Ala Val He Gly Leu Arg Phe Leu Val Ser Leu Ala Gin Asp

325 330 335

Ser Lys Leu Pro Lys His Phe Lys Pro Gly Met Gly Glu Asp Tyr Cys

340 345 350

Trp Phe Asp Val Arg Thr Trp Gly He Leu He Tyr Tyr Tyr Gly Pro

355 360 365

He Ala Leu Leu Leu He Phe Ser He Val Cys Cys Leu Lys Ala Tyr

370 375 380

Phe Ser He Tyr Glu Leu Pro Pro Asp Thr Gin Tyr He Leu Gly Thr 385 390 395 400

Gin Leu Lys He Val Lys Thr His Phe Tyr Ala Phe Ser Ala Tyr He

405 410 415

Val Gly Val Phe Ala Val Trp He Arg Glu He Val Val Tyr He Met

420 425 430

Ala Arg Val Arg Glu His Phe Phe He He Asp Phe Trp Ser Gly He

435 440 445

Cys He Leu Gly Leu Ala He Ala Gly Phe He Leu Leu Leu Gly Lys

450 455 460

Asn Leu His Val Lys Ser Trp Trp Ala He Asn Val Glu Ser Ser Gin 465 470 475 480

Thr Asp Leu Ser He He Asn Ala Arg Val Tyr Lys Phe Asp Glu Lys

485 490 495

Gly Asp Leu Lys Ser Ser Asp Ser Pro Tyr Lys Pro Thr Val Thr Ser

500 505 510

Leu

<210> 166

<211> 5208

<212> DNA

<213> Drosophila

<400> 166 cgagccattt ccagacttat cttgagatag atataaaagt taagaatatt agattagatt 60 atttccatcc attttctata atttattgcc tttgcgaccg taaagaaaat ccaattttta 120 accgacaatc caaatggccc aaacgaattt accacagctt tagtttttaa atatttaggt 180 gcatttccag gctatacaaa gtttgtctac atgtaggtgt gtgacctggc ttgatatcgt 240 ttacggtctt caagaatatt cgaaaagatt cgttgatttt tgacaaacag atccgctgag 300 gaaaaaacga cgttcatttt atctttggct ttattaagct tgaaatacaa ttataattct 360 tgtattgtgt tttacattag ttcagagata atgcagatat ggagaatggt acatttatgc 420 aaagagggta tacaatcaac accaatctcg tttttaacaa ggcacatctg tatgttacgt 480 atttttgctg gatgtttacc ttggacttag gctaatggag aattacaaat ttgatctctc 540 agctgggttc ggagaacctt acaattttgc ttgcataaac agtagatatg gctctgcata 600 aatttcttat acaactaatc aggttgttcg tggtcacatg gcattaaaaa atgaaagaga 660 attgggcggg gtggggtggg taagggtttt cgtggtagtt ctgggggata gggactttct 720 cttatagtag tgtctttcat aaagttctat ccgtatgtgg atgctacttc gcgaatttat 780 agatatcgac tttaaatgtt gattacagaa taatctcatg ataggaatat gtagtcctaa 840 aatatgaata agtgatcttt atctacagaa aggaacgcag tgttcgcaat aatgcgagga 900 tccgatcgaa atgaatataa atgcgattag tccttcctga tctgcacgca tcccgaggta 960 ttcaatgctc tgcctatggc ggcaactgcg agtgctgtga tcagcggaag atggtggttt 1020 tctgaggatc cacgctcgag ctgatcacta gcggcttctc caccgatggc ttctcgtgca 1080 gcgacagatt ggccacgctg ctcgacgtgg tcttggtgga gtactggctc tgacgttggt 1140 tgctgccatc gcgaacactc gagcatctgt gtttgtgtga agtggtggag tggttatgac 1200 gtccattgcg tgggcagcgt ggaatagaca atggcggtaa atctgattag aattggttcg 1260 tttgagtgct tggattttaa gttagggaaa agcagacaca ttaagcgatc ctacaggata 1320 taaacaggtt accttcacca agacacaaaa gtggatggtc attatgatta gttttcgagg 1380 ggttagaggt tatcagggtt atctaatggt ttcttccaac tggggttaac tacaatgtca 1440 actacttctc catttccaga ggattacctg tgaccatttt gattagatgg ctatcttcgg 1500 ggtcggactc gggtcggtgg cattgctacc ggccttgtca acagccttaa ggtgcagctt 1560

210 tcttggcagc acattcgcgt cagaagtgat ggaagtcgag gtagtggtcg agctcaggcc 1620 attcgagcgc cttttctcca ggagtcttca atgaatagcg atcgatgatg atcaaattga 1680 tgttgagaca catgcacata tggacacaca tggtggatgc aaacataagt ttgtgtttag 1740 atcagggcaa ttaggaatgg tacttctgtt tagtagctac aaagacgcga ccggactgag 1800 tcaccgagct aggcggctgg agattcagtg ctgtgttggc tgtcagtgtt cggtttagag 1860 ttagtctgca ggcagtgtct gttggtgttg agcttgcttt taagcaatat cgaaagcagt 1920 ctgacaacga aaataagtac aacatataag gtttaaaata atcacagatt gcgcgctgtc 1980 agaactcgaa gtgcatatgt attcccataa tcttcaatgg gtcttccatc ttagtgcaag 2040 agatttaagg aacgtggaat tagacaggaa tcatataacc cgaaattttc aatattcttg 2100 atttaagcgc gggttagcaa aggccacaac aaacgagcaa ccgagctaaa ggagaccttc 2160 ttactgaaat cgacgaaatc gatttagact tcgtgtgaat gaataccact ggtggaccca 2220 ttggcaaatg cgttgcggat caccaccagc ttgcggatct ggttggaggc gtccataaac 2280 cgctgcttca tcgagaacga agtcggtccc atcgttacgc tctcagtctg ccgcagactg 2340 cgcacacgta tcgttctgag aatagtcggg gttacagata tgatggtgga cagagtcaga 2400 gacacgacac acaagaggga gtcacgagtc gtgtgaatgg acaaacgccc agtgggcggg 2460 acaggacata acgtggagtt aagaatagag caacacttac ctgtttgtga tcaagtgctt 2520 gaccttcttc ttcattacaa acaacatgaa aatgagaaag ccctgcatcg cattggccag 2580 atccgagata taaaagagct tagaccatcc cttgtcgctg cccacgaagt acgagataag 2640 ctccgtgagc caggtgatgc ccattatgag aaagaggcgt aagaacaagc cgaatctata 2700 gttggaccaa gcacgataaa aacgtcttta ggggaaggtg gataagaaat actgaaagga 2760 tgacactcac ttgtccttct cggttcgtag gttcttggtg ctgttctcac tcgcaattat 2820 ccgggccatc tcgcgctgca cgccgtgaat cttaatcgcc gtcattatga acatgatggt 2880 gttggcaaca acgatcgcca gaatgggacc gtagaaatag atcatggctg cccagttgct 2940 catatccagc cagcagtata caccatcacc aatacctggc tttaggttcg cgggcaaatt 3000 ggtaagttgc tgggcgcaat aggtgaaggc taggaaaact agggcaatac cccaagagta 3060 cagcgaataa aacaggaagc gtttcttctc ctggaatcgg ttaattcctc tcgtccctcg 3120 gaaattgtgc cacaagtcaa agctaatgac acttagccac atgtaggcac ccataaaaaa 3180 gaaatatgct gtgtatccaa acactttgca tgtaacacca gtggcatcaa cttgatagag 3240 ttgcacgtag cacagcgagg agtaacccac ggagagccct attaaatagc agaccaagct 3300 ctttccgtgc tggttgcgga gctcgggaat caataggtaa acggctatgg taagcatcat 3360 gaagggaatg gagaacatca tggctagtgc aaggaatttc ggtcggatta ataaaatgct 3420 gtttacaaga agtaaaggtg atcgtttcac ttaccatacg aattgataat ctttaccgtg 3480 ctatgatcgt cctgcatgtc acaattggcc ggatgtatgg tgtagaacat gtccgattcg 3540 ttgacgtatg tcggaaccat gcagaactcg ttcttcctga ttagcagttt atcgtccaca 3600 cggagcatgg atccgttctc aaagagtaga taatcatccc aattgttggt ctctggctgc 3660 agagaaaaca tcttggggca gggtctgaag ctttggatag caaactgcgt aaacatgttg 3720 accaatatcg tagactcgtt gcggaaggtt atattgagca taggcggatc tggccacgtt 3780 cggttgtccg agtggtctat tatgcatccg tcaacttcag agttaaagac ctgccgccac 3840 gggcagcaga tattcaggca ggacttgaac ttgcagacgc atcccctaac gtgttcccga 3900 acctctatgc gctccgttag cgagctgtgt atgtagtcgt acgtcccgac caattctgcg 3960 ggaactattg tgccgtagta atcatagctt ccgttgggaa agagcctatg gcccgtcaga 4020 ttcactgtat cgtagaaatt acagggcaca tttggatcgt ctatggtgtg gtagtggtct 4080 ctctcggcca taacgtaagt gccgaaggga atccccggaa tcaaccggaa cacgaccaag 4140 cacaggacgc ccagcaatgt aactccgcag tatagggatc ctccaggctg atgaattttc 4200 ttcggcataa tgaaggttct gaaattcgta aatctttatt aaatattatt acaaatattt 4260 gttattattc tttaacgttt attcttttaa cgtttaaata ttcagtggaa tatagttatt 4320 acagttagtc atcagtcgca acacgcagca attaagcctt agcaagtgaa gtcactaatt 4380 aagacctatt tgccgattag ttagtcgttt aatgtttatc taagtgagtt cactaatttg 4440 ggcaatagag caacatctag ggacccatta gcggggacga gtggtgaatg atctatgcgg 4500 acaacaggtt gtcgaaaaga attaaggagg cgaaacagga tagcgtcaca agcaattagc 4560 agccaacgtg tcccatgggg aggaaccagg ggcggactac ccacgacctg agcgccattc 4620 tccgcgggac atcaatcata aggtcaacca cgcagggagt gcagactgag caaacattta 4680 tggattcgtg ttaaattgat agtaactgcc attgtctgtc aatagaggtg acagtctccc 4740 cgaactccac tccaaaccaa tcccgatctg cccacttttc aagcgctgct aacgagcccg 4800 tccataaatt cattaccagt gcgaaaagtt ataccgctcg ctatcttatc ttgtatcatt 4860 agcctttggg gaccaactaa ttcattgatc cgctgattgt ttgcctttgg gggagaagca 4920 gaagggtaac ctgcggcatt gtcaggagtg tgggccacta aattagtccg aatttatggg 4980 atgcgaacgg gtggagaagg acaaacacat taaactccgc acagttggct aatggggaaa 5040 atgaatactg gcagtgggtg gggaagggag agccagagca cttatcttgc ggtgggaaat 5100 tagcataatt aatcgctgag cacatgcact tgggaaattt cagcggacca aattcaatcg 5160

211 tatatatctg cgcactttaa atgtgcgaat gagtgctgcg gatgtttg 5208

<210> 167 <211> 1914 <212> DNA <213> Drosophila

<400> 167 atgccgaaga aaattcatca gcctggagga tccctatact gcggagttac attgctgggc 60 gtcctgtgct tggtcgtgtt ccggttgatt ccggggattc ccttcggcac ttacgttatg 120 gccgagagag accactacca caccatagac gatccaaatg tgccctgtaa tttctacgat 180 acagtgaatc tgacgggcca taggctcttt cccaacggaa gctatgatta ctacggcaca 240 atagttcccg cagaattggt cgggacgtac gactacatac acagctcgct aacggagcgc 300 atagaggttc gggaacacgt taggggatgc gtctgcaagt tcaagtcctg cctgaatatc 360 tgctgcccgt ggcggcaggt ctttaactct gaagttgacg gatgcataat agaccactcg 420 gacaaccgaa cgtggccaga tccgcctatg ctcaatataa ccttccgcaa cgagtctacg 480 atattggtca acatgtttac gcagtttgct atccaaagct tcagaccctg ccccaagatg 540 ttttctctgc agccagagac caacaattgg gatgattatc tactctttga gaacggatcc 600 atgctccgtg tggacgataa actgctaatc aggaagaacg agttctgcat ggttccgaca 660 tacgtcaacg aatcggacat gttctacacc atacatccgg ccaattgtga catgcaggac 720 gatcatagca cggtaaagat tatcaattcg tatgccgttt acctattgat tcccgagctc 780 cgcaaccagc acggaaagag cttggtctgc tatttaatag ggctctccgt gggttactcc 840 tcgctgtgct acgtgcaact ctatcaagtt gatgccactg gtgttacatg caaagtgttt 900 ggatacacag catatttctt ttttatgggt gcctacatgt ggctaagtgt cattagcttt 960 gacttgtggc acaatttccg agggacgaga ggaattaacc gattccagga gaagaaacgc 1020 ttcctgtttt attcgctgta ctcttggggt attgccctag ttttcctagc cttcacctat 1080 tgcgcccagc aacttaccaa tttgcccgcg aacctaaagc caggtattgg tgatggtgta 1140 tactgctggc tggatatgag caactgggca gccatgatct atttctacgg tcccattctg 1200 gcgatcgttg ttgccaacac catcatgttc ataatgacgg cgattaagat tcacggcgtg 1260 cagcgcgaga tggcccggat aattgcgagt gagaacagca ccaagaacct acgaaccgag 1320 aaggacaaat tcggcttgtt cttacgcctc tttctcataa tgggcatcac ctggctcacg 1380 gagcttatct cgtacttcgt gggcagcgac aagggatggt ctaagctctt ttatatctcg 1440 gatctggcca atgcgatgca gggctttctc attttcatgt tgtttgtaat gaagaagaag 1500 gtcaagcact tgatcacaaa cagaacgata cgtgtgcgca gtctgcggca gactgagagc 1560 gtaacgatgg gaccgacttc gttctcgatg aagcagcggt ttatggacgc ctccaaccag 1620 atccgcaagc tggtggtgat ccgcaacgca tttgccaatg ggtccaccag tgatttaccg 1680 ccattgtcta ttccacgctg cccacgcaat ggacgtcata accactccac cacttcacac 1740 aaacacagat gctcgagtgt tcgcgatggc agcaaccaac gtcagagcca gtactccacc 1800 aagaccacgt cgagcagcgt ggccaatctg tcgctgcacg agaagccatc ggtggagaag 1860 ccgctagtga tcagctcgag cgtggatcct cagaaaacca ccatcttccg ctga 1914

<210> 168 <211> 637 <212> PRT <213> Drosophila

<400> 168

Met Pro Lys Lys He His Gin Pro Gly Gly Ser Leu Tyr Cys Gly Val

1 5 10 15

Thr Leu Leu Gly Val Leu Cys Leu Val Val Phe Arg Leu He Pro Gly

20 25 30

He Pro Phe Gly Thr Tyr Val Met Ala Glu Arg Asp His Tyr His Thr

35 40 45

He Asp Asp Pro Asn Val Pro Cys Asn Phe Tyr Asp Thr Val Asn Leu

50 55 60

Thr Gly His Arg Leu Phe Pro Asn Gly Ser Tyr Asp Tyr Tyr Gly Thr 65 70 75 80

He Val Pro Ala Glu Leu Val Gly Thr Tyr Asp Tyr He His Ser Ser

212 85 90 95

Leu Thr Glu Arg He Glu Val Arg Glu His Val Arg Gly Cys Val Cys

100 • 105 110

Lys Phe Lys Ser Cys Leu Asn He Cys Cys Pro Trp Arg Gin Val Phe

115 120 125

Asn Ser Glu Val Asp Gly Cys He He Asp His Ser Asp Asn Arg Thr

130 135 140

Trp Pro Asp Pro Pro Met Leu Asn He Thr Phe Arg Asn Glu Ser Thr 145 150 155 160

He Leu Val Asn Met Phe Thr Gin Phe Ala He Gin Ser Phe Arg Pro

165 170 175

Cys Pro Lys Met Phe Ser Leu Gin Pro Glu Thr Asn Asn Trp Asp Asp

180 185 190

Tyr Leu Leu Phe Glu Asn Gly Ser Met Leu Arg Val Asp Asp Lys Leu

195 200 205

Leu He Arg Lys Asn Glu Phe Cys Met Val Pro Thr Tyr Val Asn Glu

210 215 220

Ser Asp Met Phe Tyr Thr He His Pro Ala Asn Cys Asp Met Gin Asp 225 230 235 240

Asp His Ser Thr Val Lys He He Asn Ser Tyr Ala Val Tyr Leu Leu

245 250 255

He Pro Glu Leu Arg Asn Gin His Gly Lys Ser Leu Val Cys Tyr Leu

260 265 270

He Gly Leu Ser Val Gly Tyr Ser Ser Leu Cys Tyr Val Gin Leu Tyr

275 280 285

Gin Val Asp Ala Thr Gly Val Thr Cys Lys Val Phe Gly Tyr Thr Ala

290 295 300

Tyr Phe Phe Phe Met Gly Ala Tyr Met Trp Leu Ser Val He Ser Phe 305 310 315 320

Asp Leu Trp His Asn Phe Arg Gly Thr Arg Gly He Asn Arg Phe Gin

325 330 335

Glu Lys Lys Arg Phe Leu Phe Tyr Ser Leu Tyr Ser Trp Gly He Ala

340 345 350

Leu Val Phe Leu Ala Phe Thr Tyr Cys Ala Gin Gin Leu Thr Asn Leu

355 360 365

Pro Ala Asn Leu Lys Pro Gly He Gly Asp Gly Val Tyr Cys Trp Leu

370 375 380

Asp Met Ser Asn Trp Ala Ala Met He Tyr Phe Tyr Gly Pro He Leu 385 390 395 400

Ala He Val Val Ala Asn Thr He Met Phe He Met Thr Ala He Lys

405 410 415

He His Gly Val Gin Arg Glu Met Ala Arg He He Ala Ser Glu Asn

420 425 430

Ser Thr Lys Asn Leu Arg Thr Glu Lys Asp Lys Phe Gly Leu Phe Leu

435 440 445

Arg Leu Phe Leu He Met Gly He Thr Trp Leu Thr Glu Leu He Ser

450 455 460

Tyr Phe Val Gly Ser Asp Lys Gly Trp Ser Lys Leu Phe Tyr He Ser 465 470 475 480

Asp Leu Ala Asn Ala Met Gin Gly Phe Leu He Phe Met Leu Phe Val

485 490 495

Met Lys Lys Lys Val Lys His Leu He Thr Asn Arg Thr He Arg Val

500 505 510

Arg Ser Leu Arg Gin Thr Glu Ser Val Thr Met Gly Pro Thr Ser Phe

515 520 525

Ser Met Lys Gin Arg Phe Met Asp Ala Ser Asn Gin He Arg Lys Leu

530 535 540

Val Val He Arg Asn Ala Phe Ala Asn Gly Ser Thr Ser Asp Leu Pro 545 550 555 560

Pro Leu Ser He Pro Arg Cys Pro Arg Asn Gly Arg His Asn His Ser

213 565 570 575

Thr Thr Ser His Lys His Arg Cys Ser Ser Val Arg Asp Gly Ser Asn

580 585 590

Gin Arg Gin Ser Gin Tyr Ser Thr Lys Thr Thr Ser Ser Ser Val Ala

595 600 605

Asn Leu Ser Leu His Glu Lys Pro Ser Val Glu Lys Pro Leu Val He

610 615 620

Ser Ser Ser Val Asp Pro Gin Lys Thr Thr He Phe Arg 625 630 635

<210> 169 <211> 3957 <212> DNA <213> Drosophila

<400> 169 ccagacatgc ttcctcgatg gggcttaacg tcagcggagc agcgatgtca gtggcagcca 60 tcatctgaac cgaatgacag tggaggtcgc tagaaaaggg gttccatttc cactagttta 120 tactaccgaa ctgatactta aatcaaggca gttaaaaatt taatatgaaa ccggaaatgg 180 cttcaacatc tcgttaacgc tctgcccaat tctacagtca tccgatttta atgaagcaaa 240 atttactgcc atgccatgca agagatatga atcaccgcat gggaatagcc cacaaaggac 300 ccttacccca tgcactctat catgaacacc gcacacactt ttaatctgcg actaattgct 360 gctccgtatt gaattgattt cggttgcccc aaagtgccac attccaaatc tccgttgatt 420 ggggaaatcc ccgaaaaaca ttcgaaccat tcgtccctgg cgagcacaga aacagcgtct 480 ctgattctgg caggaattgg agggcatagg gcggaccttg tggcggtttg tcgagtgcac 540 aaagtgcaag gttgcgtggc cattcatttc gcagccgatg ggtggaagtg ggcagcggtg 600 ggtggcgccc ggaaggaaga gcatcagtaa tctctaagtg cgccttgttc gcattcgtac 660 tcgtgccagc attgcataag tgtcagtgtc aacggggcgg ggatgtggtt gtgcttggtg 720 gttatgtggg tgtttgtgtg gtagtagtgt ccttgttggc agacaaaaag actgatgatg 780 atggcatttt gttactttgc taccttcctt tgtcgcccgt cgcacggcag ctcctttagt 840 atgaaatgag gcgaccaggc aagcgcctcg tcatcgaaga tcacccaaac agagtacgga 900 ccaggacacg gcaactcgca caggcacagg aacaggtgca ggcacaacaa ctggcaggag 960 catcggtgtc ggcaagggat actggcgcgg gatcgaaagc atgaacaggg acaatctgca 1020 gcagtggtgg gagaactcgt atcggcgcca acatccagag cccaccgatg acctcggcct 1080 ggactccgcg gagctgcatc tcgccctcca ggagcccaac cagctgcccg cggactacga 1140 ctatggcaac tttagtctag gcaatccgta tgacgtggac tcagagcact ccatttcccc 1200 gctgacgctg ctcctgctcg ctgttagcta tggcctggtg gttttcggcg gcgtcgtggg 1260 caactccacg ctcgttctga ccctctgctc cgcctcttcg gtgcgtttgc gtaacccgct 1320 gctgctggcc gtctgcattg ccgatctcct ggtcaccggc atctccgctc cggtcacgct 1380 cctcaatctc gcgatgaacc ggaggacgcg atcgctgccc cttgtgctgt gcaaggtcat 1440 acactacgta caggtgagtg ggtcaatcaa acaagcttaa gttagccaag taactaagtt 1500 aaccccacgc tattcaggtc atgcccgttt cggccagcac tatttcgttt ttcatgctct 1560 cccttgaccg ctacgccaca gtaaagcatc cgcgattggc gcagcttcgc cagcggcgct 1620 acttgcacgt ctccctggcg ctgctatcct ggctcgcctc tgccgccatc agcactccct 1680 ttctgtttgc ctacaaaatc atcgccaagt cgatggtggt caagggcggt ggggcggcga 1740 acaccacgcc aaacccggtc agcatcagct gcacctccga cctgggcgcc aacgccatgt 1800 tcatgtcctt catcatcttc cacaccatcg ccgtgttcgt gttgcctggc attggtgtgc 1860 tactcaacca ctacggcgtc cgacgcaagc tctgcgccct gtcgctaacg gctcgagctg 1920 cccatggaga gctgccgctg cccattccca tcctgcgacg ccagacccac atggtcattg 1980 tgacgggctg ccccaacgcc cagcaagcgg cctgtggtgg gggcaccacg gcggacgaca 2040 cctcgaacgg gaacggcacg ggcaccggtg gcggtcccat ggccgtcagt ccgggcgaca 2100 tacagcttca cacactgcag ccgcgccagc caggctctgc cggatcggcc ctcgaaccgg 2160 gctcctaccg ctctagcaat cccatatcac ccaggtaagt cataaatatt gtgaagttat 2220 cagcaaaatc gttgtaaaca ggatgtatgc ttgatgtagt caaaagctat tagtttatgt 2280 taatcatacg ccccgttgac tttggtcaga atatatttca tcgaatggca gtacgtcatt 2340 tggtataagt taactaactt gcaaacccac ttagggccat gagggagatt cgcgcccact 2400 cgcagcgcca gcgcatcaac cgagcaggca ggggaccagc gacacccggc atcccactgc 2460 cccaaacctc cacgctgcgg tcgcgaaggc acctggctaa catgctcatc gcctcggccg 2520 tgatcttcat tgcctgctgg gcaccgcacg tcttctgcat cttctacaag aacttcggca 2580

214 acaatcagca gtgcagccag acctctgttt acttcagcct tctgctaggt aagtctgaat 2640 tggcaatcat tcccaatccg aatccgagtc cgaattggaa ctgactagtt gatcgcgttg 2700 caggctactt ctactcggcc atcagtccgg tgatctactg ggcgctcaac cacaattcgc 2760 ttcgacaatc tccctgcgcg cccatcatcc gcctgcgctc catgcagaac ttcctgaggt 2820 cgcgcttccg gacgcacacc gccccgccgc ctccctcgtc caccaacgag gcggcactgg 2880 gggcattcaa ccccaagctg atcaagctaa caccgaaaca gtatagagct caggcctctt 2940 cgcattatct ctactagtgt gatactaagc taaacttgat atacatatat acacatttat 3000 atacacgcat atatagtata ttttttacct acgaccccac cccccccctg acccgtcgat 3060 gccctcttag taccctctag tatcgaactc cgaacccgaa ctttgaccca accgaacgaa 3120 actatctaga tgtttttcaa aagctctacg caacaattgc ataatacgaa agatacatgc 3180 tacatataca catatataga gtacatacta ccttgcatag cagtgttagt cgacgcttat 3240 ttacacgatg ttgtgcgcct gaagctatgc aataaggaca ccggagtcct gccgcaactc 3300 ttgcctataa cgaggatagc actggtaacg aaagcaagaa aaaaaaaagg aaaaaaaata 3360 caaaaataac gaaacccttc tagtgacttg ttcgaattgt tgtttagtct tttaagctga 3420 aatattgtac tatgttcctt ctcatagata agcaataagt gaacgcttta agccaagtta 3480 aacaaacgga aaacgaatca aactaaacta aaactcgatc taaaactttt aaacgattta 3540 aacgtaaact cgaaagcata cctaacgaaa cattaataat tatatacata cgcgactaca 3600 tacaaataac aactaacaag tgaaaactaa aaacaaaaaa tgaatgtaaa tgtgagcaaa 3660 aaaacaaaag gataacattt agtattgtat acatattctt cgacttaatt ctttatacac 3720 tttttctaac catttttaat atcgttcagt aaactgaaca cggtgtatag ggcaattcaa 3780 gctgctggat atattcgcgt ttcagatgcc agagccaccc aaaggatcgg actctggatc 3840 gggtttcatt tcactccatt cagtggcgac cgtttcctaa tttgccaaac ttttgtacat 3900 gctccgctgc gagcgactct ctccttactc cacctggttt ttcgttcaat ccttgga 3957

<210> 170 <211> 1638 <212> DNA <213> Drosophila

<400> 170 atgaacaggg acaatctgca gcagtggtgg gagaactcgt atcggcgcca acatccagag 60 cccaccgatg acctcggcct ggactccgcg gagctgcatc tcgccctcca ggagcccaac 120 cagctgcccg cggactacga ctatggcaac tttagtctag gcaatccgta tgacgtggac 180 tcagagcact ccatttcccc gctgacgctg ctcctgctcg ctgttagcta tggcctggtg 240 gttttcggcg gcgtcgtggg caactccacg ctcgttctga ccctctgctc cgcctcttcg 300 gtgcgtttgc gtaacccgct gctgctggcc gtctgcattg ccgatctcct ggtcaccggc 360 atctccgctc cggtcacgct cctcaatctc gcgatgaacc ggaggacgcg atcgctgccc 420 cttgtgctgt gcaaggtcat acactacgta caggtcatgc ccgtttcggc cagcactatt 480 tcgtttttca tgctctccct tgaccgctac gccacagtaa agcatccgcg attggcgcag 540 cttcgccagc ggcgctactt gcacgtctcc ctggcgctgc tatcctggct cgcctctgcc 600 gccatcagca ctccctttct gtttgcctac aaaatcatcg ccaagtcgat ggtggtcaag 660 ggcggtgggg cggcgaacac cacgccaaac ccggtcagca tcagctgcac ctccgacctg 720 ggcgccaacg ccatgttcat gtccttcatc atcttccaca ccatcgccgt gttcgtgttg 780 cctggcattg gtgtgctact caaccactac ggcgtccgac gcaagctctg cgccctgtcg 840 ctaacggctc gagctgccca tggagagctg ccgctgccca ttcccatcct gcgacgccag 900 acccacatgg tcattgtgac gggctgcccc aacgcccagc aagcggcctg tggtgggggc 960 accacggcgg acgacacctc gaacgggaac ggcacgggca ccggtggcgg tcccatggcc 1020 gtcagtccgg gcgacataca gcttcacaca ctgcagccgc gccagccagg ctctgccgga 1080 tcggccctcg aaccgggctc ctaccgctct agcaatccca tatcacccag ggccatgagg 1140 gagattcgcg cccactcgca gcgccagcgc atcaaccgag caggcagggg accagcgaca 1200 cccggcatcc cactgcccca aacctccacg ctgcggtcgc gaaggcacct ggctaacatg 1260 ctcatcgcct cggccgtgat cttcattgcc tgctgggcac cgcacgtctt ctgcatcttc 1320 tacaagaact tcggcaacaa tcagcagtgc agccagacct ctgtttactt cagccttctg 1380 ctaggctact tctactcggc catcagtccg gtgatctact gggcgctcaa ccacaattcg 1440 cttcgacaat ctccctgcgc gcccatcatc cgcctgcgct ccatgcagaa cttcctgagg 1500 tcgcgcttcc ggacgcacac cgccccgccg cctccctcgt ccaccaacga ggcggcactg 1560 ggggcattca accccaagct gatcaagcta acaccgaaac agtatagagc tcaggcctct 1620 tcgcattatc tctactag 1638

<210> 171

215 <211> 545 <212> PRT <213> Drosophila

<400> 171

Met Asn Arg Asp Asn Leu Gin Gin Trp Trp Glu Asn Ser Tyr Arg Arg

1 5 10 15

Gin His Pro Glu Pro Thr Asp Asp Leu Gly Leu Asp Ser Ala Glu Leu

20 25 30

His Leu Ala Leu Gin Glu Pro Asn Gin Leu Pro Ala Asp Tyr Asp Tyr

35 40 45

Gly Asn Phe Ser Leu Gly Asn Pro Tyr Asp Val Asp Ser Glu His Ser

50 55 60

He Ser Pro Leu Thr Leu Leu Leu Leu Ala Val Ser Tyr Gly Leu Val 65 70 75 80

Val Phe Gly Gly Val Val Gly Asn Ser Thr Leu Val Leu Thr Leu Cys

85 90 95

Ser Ala Ser Ser Val Arg Leu Arg Asn Pro Leu Leu Leu Ala Val Cys

100 105 110

He Ala Asp Leu Leu Val Thr Gly He Ser Ala Pro Val Thr Leu Leu

115 120 125

Asn Leu Ala Met Asn Arg Arg Thr Arg Ser Leu Pro Leu Val Leu Cys

130 135 140

Lys Val He His Tyr Val Gin Val Met Pro Val Ser Ala Ser Thr He 145 150 155 160

Ser Phe Phe Met Leu Ser Leu Asp Arg Tyr Ala Thr Val Lys His Pro

165 170 175

Arg Leu Ala Gin Leu Arg Gin Arg Arg Tyr Leu His Val Ser Leu Ala

180 185 190

Leu Leu Ser Trp Leu Ala Ser Ala Ala He Ser Thr Pro Phe Leu Phe

195 200 205

Ala Tyr Lys He He Ala Lys Ser Met Val Val Lys Gly Gly Gly Ala

210 215 220

Ala Asn Thr Thr Pro Asn Pro Val Ser He Ser Cys Thr Ser Asp Leu 225 230 235 240

Gly Ala Asn Ala Met Phe Met Ser Phe He He Phe His Thr He Ala

245 250 255

Val Phe Val Leu Pro Gly He Gly Val Leu Leu Asn His Tyr Gly Val

260 265 270

Arg Arg Lys Leu Cys Ala Leu Ser Leu Thr Ala Arg Ala Ala His Gly

275 280 285

Glu Leu Pro Leu Pro He Pro He Leu Arg Arg Gin Thr His Met Val

290 295 300

He Val Thr Gly Cys Pro Asn Ala Gin Gin Ala Ala Cys Gly Gly Gly 305 310 315 320

Thr Thr Ala Asp Asp Thr Ser Asn Gly Asn Gly Thr Gly Thr Gly Gly

325 330 335

Gly Pro Met Ala Val Ser Pro Gly Asp He Gin Leu His Thr Leu Gin

340 345 350

Pro Arg Gin Pro Gly Ser Ala Gly Ser Ala Leu Glu Pro Gly Ser Tyr

355 360 365

Arg Ser Ser Asn Pro He Ser Pro Arg Ala Met Arg Glu He Arg Ala

370 375 380

His Ser Gin Arg Gin Arg He Asn Arg Ala Gly Arg Gly Pro Ala Thr 385 390 395 400

Pro Gly He Pro Leu Pro Gin Thr Ser Thr Leu Arg Ser Arg Arg His

405 410 415

Leu Ala Asn Met Leu He Ala Ser Ala Val He Phe He Ala Cys Trp

420 425 430

Ala Pro His Val Phe Cys He Phe Tyr Lys Asn Phe Gly Asn Asn Gin

216 435 440 445

Gin Cys Ser Gin Thr Ser Val Tyr Phe Ser Leu Leu Leu Gly Tyr Phe

450 455 460

Tyr Ser Ala He Ser Pro Val He Tyr Trp Ala Leu Asn His Asn Ser 465 470 475 480

Leu Arg Gin Ser Pro Cys Ala Pro He He Arg Leu Arg Ser Met Gin

485 490 495

Asn Phe Leu Arg Ser Arg Phe Arg Thr His Thr Ala Pro Pro Pro Pro

500 505 510

Ser Ser Thr Asn Glu Ala Ala Leu Gly Ala Phe Asn Pro Lys Leu He

515 520 525

Lys Leu Thr Pro Lys Gin Tyr Arg Ala Gin Ala Ser Ser His Tyr Leu

530 535 540

Tyr 545

<210> 172 <211> 7112 <212> DNA <213> Drosophila

<400> 172 gaatgataac taattcaata aaactacaga tttcaataac taaagcatac atgtatatgt 60 atctatgtat ctatgactat gtatctcgaa tcctccgctg aaactctaaa ctattcccat 120 gcagtttctt ttccttcgta tcgagtttca gagcacggct tgtagtgttg cacgtttttc 180 gtattttttg gcagctctgg ctggtttttt tcattttcct tttttttttg tactcccatt 240 tcctgtcacc ctgcccggtg taattaaaaa agtttttctc gacatttgct tgccatgtga 300 ggctccagga acaaatgcgt tacattgtgg accatccgat tgtaaaataa attttaagtg 360 caatacgaag tgcaaactca gccgtaacaa taagattttt gcaataatat ttaactttta 420 attgtaactt tggtaaagtc aatgttttct ttttccaagt tggccaataa aaagagcata 480 aagcaaagcg aaaactttag tgcgtacttt tattacaaca ttaacttcat gctatatatt 540 ttatttaaat attttggctt ttctatccat tgtttttcag ttaatatctt aaacaaacaa 600 tttttgatgc actacaaatg ctgttgattt taataaacga tttatagctt acatggatta 660 ttagctatgt acatataatt acgaatattt ttaataaagg gcatacttaa taaattgaaa 720 ttctggaaaa cactcattta tttaacacta gcaaattagc gcacaaataa tgtgcaaagt 780 tcgttaatct ttaaagtgta tttgtgacca cagcacaatt aaacggtggt ccgaaattct 840 atatcttcta attccgcatt gttttttttt ttttgtgaat ttttcaggta acctccttgt 900 tattttggtg gtcacattat cacgacgact gcgctcaata accaactttt tcctcgccaa 960 cttggcgttt gccgacttct gtgttggact cttttgtgtg atgcagaatc tgtccatcta 1020 tctgatagaa aggtgagtga caattggcaa aaacaacatt atttcagtat taaattaacg 1080 tttcatcatg cacgagcgga gctgcaaaat tctcggaaag catatacgaa gaatacgtga 1140 actaacttca ctgtaaagtt gccaatagtt tttaatgtcc gttttcatac gcaaaaaatt 1200 taagtgaagc atttaagtga agcatttata gaaaagtttt tagttatagt aggttaaaaa 1260 ttaacacaaa agttaaagta gcgtttcagc tagtacagat agtagaatgt tatgtggtcg 1320 attaaattta tttatttatc agctgcagaa tgtggctgaa acggtatctg agtgcatacg 1380 tatgtatgca tgtgcctcga aaacaaagcc ccaaaaaaaa gtttcaactt tcaaccgtga 1440 aacatttacg ccggctgtca cataaaggaa actaaaactc cgcaggcgtc actttcactt 1500 caggcttttc aggcttttat ccccacgctc cgctttcact ccaatcatgt ttatttgcat 1560 tgtgtttcct taactttccc aaaaacacgt cgcagtgacg tgttcactta aaataaagcg 1620 tggagtgctg cttgaaaatt caaacaaaaa gaagcctttt tcagatttgc agggcaaatt 1680 aaaaaagtat tttgacaaat gagtttggct tacagtttct ataagttatt taatttaaaa 1740 ttttagtcgc agtgtcagaa ataaataatg cttcattaat ttaaatttgt gaaatgcatg 1800 tgtttaatat gtgtttaatt aaaagctatg ttctatacat ttagaaaaaa aagtaattac 1860 ctatctcatt agaattcttg aaatgaccat ttatttatgc acttaataat aaacagacat 1920 aatgatttat ttgcattccc gatgttaaat cctgaaattg gtttgcatat tttccatttc 1980 attttctaat atgctttttg tggccaaaga actaaattat tgagatgacc catctgtgtt 2040 tggcataatt ttagctaaat tatgcgcaca acttgacgcc caccagaaat catatgcaaa 2100 atgagatgag attacgaaaa atcataattt atgcatttat aatttatatg tgcggcatac 2160 ggctgccagt gacaatttaa tttaatgatt ataaacatca agtcgtttta agaaagtttt 2220

217 tagttcatta tgttaaggaa tgatttgtcc cttttaaaga gagaaattga atcaccaggc 2280 aaatggggaa tctttttaag aaacgcatta tccaaaatct tggcgacaac cttcaggatt 2340 attatgttta ttatagtatt attgggcaca tttaaacgca tgagtgcgaa attacgtggc 2400 attgctaata acgaggcaca aatgcggttt tcgaatgtaa tttcagccga aatagtaata 2460 aaaaggaaaa agctttgcgc ctcataaaat actaaagaca ccttaatgtc gcattagttt 2520 tggcgggcgt gtcataacat tttatgtggc ttgtgctaaa tttggctctg ccaccaatat 2580 tgccaagtat atgctcttta aagagcgaaa cttttgccca taaataatta tttatgtcct 2640 ttcagctggg tctttggcga gttcctctgc cgcatgtacc agtttgtcca ctccctgagc 2700 tacacggcct ccattttcat cctggttgtc atctgtatgg agcgctactt tgccatcgta 2760 caccccatta cctgcaaaca gatcctaact gcggctcgtc tgagggtaag ttctaaccat 2820 aaacctcata ttcacggcca gtaataggca agtatgcatt ttaaatgagg tctatgtgta 2880 tgtgccctgc ttttttcaat tcccattttg atgggtcaaa agcggaggaa atctgtttat 2940 gtattgtatt ttgagacatt ctcgcaactt taataacttc atttgaatac aatttgcaag 3000 ctaatgaaac ttattagacc aagcccggag actcatgcaa attaaccggc agaacagaac 3060 cgactcgaaa ggcttaataa gccgtgggca taactttgtg gccgggaaaa cttttccgca 3120 ctcgaagggt gaagtggagg gagcgcagcc aaagggttga accacatagc ccggttgttt 3180 catcacagcc agacaaaaaa tacgtttcgg taatgacgat tgcactaatt aaactacaag 3240 agacataaag acaacgaaat gggctatcca ttaacatgca aattcagtgt gttcattcgc 3300 aatttaacaa attgtttgcg tgtttggcag ccgagcagac aaaacaaaac gtcaatgcgt 3360 gttttttttt ttgcagatgg tcattgtcac agtttggatt acatcggcag tttactccac 3420 gcccaagttt gttttcagca agaccattaa gaacatccac acgcaggacg ggcaggagga 3480 ggagatatgt gtcctggacc gtgagatgtt caactccaag ttgctggaca tgattaactt 3540 tgtgcttctc tacgttatgc cgctcttggt gatgacggta agtgtaacaa atgatacgta 3600 gcttgaagtt aataattatg tttaaccaat ccttggatag gatgttcata aattcatttt 3660 caatccaaaa gtgtttccta gtcacgttac ctagcattga gcagactata attaataatt 3720 aaatgtattt ttttgaattg cttattaaag tgattaatta tatcaataac aactatctct 3780 ctaatgagat agaatataaa taattttggg tacataataa ataatctatg aaatgatttt 3840 tcttcgtctg ttaaaaaagt gattaatgga agtgtagatt tccctttatt tttttaacga 3900 ctccattttt caatttcttc tgagaaattt gataagaatt gagaagcttt ttgcataaaa 3960 tcgccccttg ttccgcaatg aaatttgaat aatgaattta acgaacccat ttgcattgca 4020 ggtgctgtac agcaaaatcg ccatcgcctt gtggcgcagt tcgcgcggcc tcacgccgca 4080 tgtggtgcag catcagcatc agcagccgca gcagccatcc tgccaggaca ttggcatggg 4140 tatgcacaac agcatgtacc atcaccatcc gcatcatcat caccaccacc accagcatca 4200 ccagctgcaa tcggcggctt cgtcggcagg agtggtggga gtgggtttgg gtggtggtgg 4260 tgggggcggt cctggtccgt cactcgcttc cggcggcagc agcaccacgt ccttgtcccg 4320 caaacagagc agtaaatatg agaagcgcgg cgtcagcatc acggagagcc aggtgagctg 4380 ccaggagaac actgcatcag aaaaatcgcc ggttgagcac ggaggagtag ccttaaaagc 4440 ctaacaatag caataaaccg aaagtggagt cgaacctttg ttccctaatt ggccagaacg 4500 gctttaactt cgattgagtc cgcacgtgct gtgtggtaaa taatgttttt tgaaaatcac 4560 atcgctatcg gagcactaat ttattagata caccatttgt cggcctggcc aagttggcag 4620 tcgtaaaaac tttacccgta gctgttactc ccgcactttc gccgggccaa gtggcacggt 4680 gctcggagca ggtgtcaatt cacattaagg ccatcgcagg accatgccac aagctcggcc 4740 accgatgtga cacctggagt gtggagtggt ggagcgaagt gaccaccggc acagggcgaa 4800 actgcaagtg cgaggccaaa gttatggcaa aagtgttttt ttttttccat tatcggtggc 4860 cggacagcag gttcaattgg tcgggtgcac catggcgtat ttcttatttc ttatttcgag 4920 ctcgacagca gctttgccac acaaactggc acacacatca ttgttcttga tcagcatcag 4980 cagctcactt tgtcaataaa agccggcgga taaaaatcga gaatttgtga cacgatgaca 5040 ttcggaaaag ttgtgcaact gccgcagatt gaaaattggt aaacaccaaa ggcaaggccc 5100 ttgaattttt taatattcct cgaagtatca aatgtcaggg gagcactggt tcgatttcgg 5160 tatgttttcc gttttaaaag tcacaaaaat ggaagtttgg taggaaaaac aatggcggga 5220 acacctttat aaaactttta cataacttta gtttacgctg ttccttaact tatgaccccg 5280 atatacacag ataacaacct aactatcttt ctgttgaact cttttctctc tctctacctt 5340 tcgtttgatc aataaaactc tgtgctctcc ccctctacta actccccaat tataacaaca 5400 accacacaca atcccacacc acaaattagc tcgataattg caaggtaggt tgtaatcgaa 5460 tatcaaaatc gatatgataa tgttcaacaa ctgttgcggc cagcgaccta atgccattac 5520 acctgttaat ccgcacaggt gtccctggag gccgatcgtc ccattgtcag tgcctgccgc 5580 aagacgagct tctaccacca cggccacgcc catcaccagc gggcgggcaa cgcctcagtg 5640 ggcggtggca gcggcggagc cggggccgga gccacccaca tgtcccactc gtccagcaac 5700 gtcctacgcg cccggcgcgg cgttgtccgc atgctgataa tattcgtgct gacattcgcc 5760 ctctgcaatc tgccgtatca tgcccgcaaa atgtggcagt actggtgagt agtcccttcg 5820

218 tccacccacc acccataatc acaatccaat gcgaatcgga atcccaatcc ctatccctat 5880 cccttaccgc aggccattca tcagcccaca cggactgagt gtaaacaata ttttatggta 5940 tattgcaccg gcaatcggcg ggaatttgca tagtcctccg ttggacggga aattaacatc 6000 tgcgagtggg cagataagct ctagatggct tcctgctgga atcgaggcta gtaaacaatt 6060 aagtcatcaa tggacagagc tggagctgca gccagctttg ccgctggcct aaatgatttg 6120 aaagcggtct tccgttttcc aatcccactc ccttcccaaa gacgccagtt tcgctttctt 6180 ctcgcctttc aaaagcggtc gccaagaaaa gtccgtttta gccagccctt tggctatcag 6240 ttccgcttcc ggtggagcac tttcgaatag gtggacggac cgcttagttt gctttgaatt 6300 cgggcaattt ggtttttccg gctggcgggt gtggtgggcg tataacttga taagtgagtg 6360 ggcggtggaa gtgtttttgt ttgctaaatc gaggaggagt taattgctcc ctgggtagaa 6420 ttaaaaacgt gcacttaagc tgctgactgc tgtaaattgg aaataaaata aaagtcacag 6480 aaatgtcctt taagcgaaag tcgaaagaca aacgattgat tgaagatggg aaaagtcatc 6540 aagtgtgaaa atctggagac attggcaatt ttggcacgta agagaaacgt ttttattttg 6600 aacttttcat acagattcta ctaaaccaaa cgtttttgag tcaattgtaa attgtaaagc 6660 attttacatg ccgatgtgca ataaatccaa tttaatgttc ataagttcat gtttttggtg 6720 aataactact gaaataaata tcgatctcta gttctcatta gtgcaaatat tcagtgtaat 6780 tttgtaagaa aatacttcgc tgcagatttg caacgttgca cttttggcaa acgcaacgaa 6840 aacgaaaatg tttttgaatt tttgttcgag cactcaattt gcacaattgt aaaacgaatg 6900 gcggacaaat aaatataaat aatatctggc caaatacaag agaaatggat ttccacatcg 6960 ccacttttcc cgcagtgcca taattgagat ttatgtctag cccggaatgg gcagcgagac 7020 ttgtttactt gtttgaactt tcagctttta tttatttgaa gaattggttg cccccaggga 7080 tattggtatt gttaggtgga attgaaagtg tt 7112

<210> 173 <211> 1437 <212> DNA <213> Drosophila

<400> 173 atgcagaatc tgtccatcta tctgatagaa agctgggtct ttggcgagtt cctctgccgc 60 atgtaccagt ttgtccactc cctgagctac acggcctcca ttttcatcct ggttgtcatc 120 tgtatggagc gctactttgc catcgtacac cccattacct gcaaacagat cctaactgcg 180 gctcgtctga ggatggtcat tgtcacagtt tggattacat cggcagttta ctccacgccc 240 aagtttgttt tcagcaagac cattaagaac atccacacgc aggacgggca ggaggaggag 300 atatgtgtcc tggaccgtga gatgttcaac tccaagttgc tggacatgat taactttgtg 360 cttctctacg ttatgccgct cttggtgatg acggtgctgt acagcaaaat cgccatcgcc 420 ttgtggcgca gttcgcgcgg cctcacgccg catgtggtgc agcatcagca tcagcagccg 480 cagcagccat cctgccagga cattggcatg ggtatgcaca acagcatgta ccatcaccat 540 ccgcatcatc atcaccacca ccaccagcat caccagctgc aatcggcggc ttcgtcggca 600 ggagtggtgg gagtgggttt gggtggtggt ggtgggggcg gtcctggtcc gtcactcgct 660 tccggcggca gcagcaccac gtccttgtcc cgcaaacaga gcagtaaata tgagaagcgc 720 ggcgtcagca tcacggagag ccagttggca gtcgtaaaaa ctttacccgt agctgttact 780 cccgcacttt cgccgggcca agtggcacgg tgctcggagc aggtgtcaat tcacattaag 840 gccatcgcag gaccatgcca caagctcggc caccgatgtg acacctggag tgtggagtgg 900 tggagcgaag tgaccaccgg cacagggcga aactgcaagt gcgaggccaa agtgtccctg 960 gaggccgatc gtcccattgt cagtgcctgc cgcaagacga gcttctacca ccacggccac 1020 gcccatcacc agcgggcggg caacgcctca gtgggcggtg gcagcggcgg agccggggcc 1080 ggagccaccc acatgtccca ctcgtccagc aacgtcctac gcgcccggcg cggcgttgtc 1140 cgcatgctga taatattcgt gctgacattc gccctctgca atctgccgta tcatgcccgc 1200 aaaatgtggc agtactggcc attcatcagc ccacacggac tgagtgtaaa caatatttta 1260 tggtatattg caccggcaat cggcgggaat ttgcatagtc ctccgttgga cgggaaatta 1320 acatctgcga gtgggcagat aagctctaga tggcttcctg ctggaatcga ggctagtaaa 1380 caattaagtc atcaatggac agagctggag ctgcagccag ctttgccgct ggcctaa 1437

<210> 174 <211> 478 <212> PRT <213> Drosophila

219 <400> 174

Met Gin Asn Leu Ser He Tyr Leu He Glu Ser Trp Val Phe Gly Glu

1 5 10 15

Phe Leu Cys Arg Met Tyr Gin Phe Val His Ser Leu Ser Tyr Thr Ala 20 25 30

Ser He Phe He Leu Val Val He Cys Met Glu Arg Tyr Phe Ala He 35 40 45

Val His Pro He Thr Cys Lys Gin He Leu Thr Ala Ala Arg Leu Arg 50 55 60

Met Val He Val Thr Val Trp He Thr Ser Ala Val Tyr Ser Thr Pro

65 70 75 80

Lys Phe Val Phe Ser Lys Thr He Lys Asn He His Thr Gin Asp Gly 85 90 95

Gin Glu Glu Glu He Cys Val Leu Asp Arg Glu Met Phe Asn Ser Lys 100 105 110

Leu Leu Asp Met He Asn Phe Val Leu Leu Tyr Val Met Pro Leu Leu 115 120 125

Val Met Thr Val Leu Tyr Ser Lys He Ala He Ala Leu Trp Arg Ser 130 135 140

Ser Arg Gly Leu Thr Pro His Val Val Gin His Gin His Gin Gin Pro

145 150 155 160

Gin Gin Pro Ser Cys Gin Asp He Gly Met Gly Met His Asn Ser Met 165 170 175

Tyr His His His Pro His His His His His His His Gin His His Gin 180 185 190

Leu Gin Ser Ala Ala Ser Ser Ala Gly Val Val Gly Val Gly Leu Gly 195 200 205

Gly Gly Gly Gly Gly Gly Pro Gly Pro Ser Leu Ala Ser Gly Gly Ser 210 215 220

Ser Thr Thr Ser Leu Ser Arg Lys Gin Ser Ser Lys Tyr Glu Lys Arg

225 230 235 240

Gly Val Ser He Thr Glu Ser Gin Leu Ala Val Val Lys Thr Leu Pro 245 250 255

Val Ala Val Thr Pro Ala Leu Ser Pro Gly Gin Val Ala Arg Cys Ser 260 265 270

Glu Gin Val Ser He His He Lys Ala He Ala Gly Pro Cys His Lys 275 280 285

Leu Gly His Arg Cys Asp Thr Trp Ser Val Glu Trp Trp Ser Glu Val 290 295 300

Thr Thr Gly Thr Gly Arg Asn Cys Lys Cys Glu Ala Lys Val Ser Leu

305 310 315 320

Glu Ala Asp Arg Pro He Val Ser Ala Cys Arg Lys Thr Ser Phe Tyr 325 330 335

His His Gly His Ala His His Gin Arg Ala Gly Asn Ala Ser Val Gly 340 345 350

Gly Gly Ser Gly Gly Ala Gly Ala Gly Ala Thr His Met Ser His Ser 355 360 365

Ser Ser Asn Val Leu Arg Ala Arg Arg Gly Val Val Arg Met Leu He

370 375 380

He Phe Val Leu Thr Phe Ala Leu Cys Asn Leu Pro Tyr His Ala Arg

385 390 395 400

Lys Met Trp Gin Tyr Trp Pro Phe He Ser Pro His Gly Leu Ser Val 405 410 415

Asn Asn He Leu Trp Tyr He Ala Pro Ala He Gly Gly Asn Leu His 420 425 430

Ser Pro Pro Leu Asp Gly Lys Leu Thr Ser Ala Ser Gly Gin He Ser 435 440 445

Ser Arg Trp Leu Pro Ala Gly He Glu Ala Ser Lys Gin Leu Ser His 450 455 460

220 Gin Trp Thr Glu Leu Glu Leu Gin Pro Ala Leu Pro Leu Ala 465 470 475

<210> 175 <211> 17847 <212> DNA <213> Drosophila

<400> 175 ccttcgactt gagcggacag ttgaggttct cgaactaatt gcaaaattgt caatgattta 60 ttcagttggc aattaaggtg ccaactaacg gtgtggctgg cacggctata tcgatttgaa 120 aatattcaat aatcccggag ccttgataag ctcatcaaac atgcacatgg ccatcagcag 180 gggggggcaa gtttgtattt agagccaagt gtgtttggtg aaggggggtt agctgtatat 240 ttcagggttt cccctttttt tgtcgagcgg tttggggggg ggttttgcga ggggacacaa 300 aagtacaagt tgctatggat caagctcaag gcgtggcagt tgggcattag ctctatggtg 360 gagcacggca accaagcgaa caaaggtcaa ctcgacaagt gagttaaatg acaaggacct 420 caccttgcct tccttgggct tcggctttgg ctttggcccg tgcgtgtttg catgtttggc 480 tcgatgaggc gacgcgaccc caaaaatgaa actcaacttt ggctttgact gcggctcggg 540 attgtggcgt gcaagcatta tggcctttcg ctttcaaaac aatgccccca tcctgtttcc 600 cggttggcct agtggcactt gctccttgtt gttggttttt cgcattgccc ttggccaatt 660 gcgagtgaat tttgatgttt tgactggcca ttcctggggc catttgacaa ctctataaaa 720 ccggtgtcct taagcccgcc ctcgtccttg cgcccaaccc ccaattaccg tccaactacc 780 acccacctac accccgctac acccacccac aaagtaaacg taattgcccg gagagtttcg 840 cgactttcga cttggccagc aaactgaaaa agcgaaactt caaaaaaccc gacttgactt 900 ggcaactgga aaagtggaaa agcggaagca cgagctttcc caccgaaaag ctctcgtgct 960 ctaagctttc gtcctggcga ggcgaaaacg taaatgtcag tcatggagtt ccagtcgtcg 1020 gatacatgtg gaacacaacg aacacagcag gagcctctcg cgtctcatcc cccgaataca 1080 atgcgaaaaa gtctgtacaa aaaatagaca aataaggagc aggagcgaaa acaccactct 1140 gtgcataaga tataactccc gcagaactga atacctgcaa aaagaaatac gcgttaaatg 1200 gaattacggt gcgggaattg ataaagtgaa gtgtgttaca gctagaaagc aagtgaaata 1260 aaacgaatac attaataatt catgcccctc atagtcagaa gcttactagt ttgataagga 1320 attcaacgta aatctgatat agtaatgtag aaaagttgta caaagtaata tacatagcat 1380 atagcatata gcacagttac acagaacaca ccgcaaactc aaacaaagtt gacaaaaaaa 1440 aagctcacgc ccctcacatc tcagtttttt ctcgaattat ttgtgaaagt gcaacaaaca 1500 tatataaaaa ataaaaaaga aaagggagga gagagcacag caaaaaaagg cagtgacagc 1560 aggacctgca aaggaattgc catcatttgg ggattacgga attatcggga tccgttctca 1620 ttaaaatgga tttaaggcaa tgccgatgtg ctgagctgca tttgtgcatg ggattatcga 1680 ttgtaatgcg cagtcatcaa attatgtttg aacaacgccg ccgcgacagc gataatagca 1740 acaataacaa caacaacaac aaccaaatca acaacaaaca ctgatttggc ccctgacccc 1800 ctttggcagc accccctcca tccaacaccc cctacgaccc tgcccaagca aaaggagcag 1860 cgaaaaagaa gaagcgtctt atgaaacaat tgaagcaccg gccaaaggag caaaggagca 1920 gacaaagaca gagacaaaaa catcggcaaa ggataaaacg gaggccgaga agaagaggaa 1980 gcagtagtag caaagcagga aacaacaaca acaacaaccg caacatcgca tttttaaacg 2040 gcaatacgca aagtaagtga agtgtaaagt gagcgagatg gcaatagaaa ggtgtagagt 2100 gccgcgaaga gaggcggaga gaatacactt gcaaaaatgt gagcagctaa ttcccaggga 2160 tgttaaaaaa aattaaaccc tcatggttca aagattctag gagatggaca agtgatgaat 2220 ggtcagtgga aatatatgta tgttttaagc caagtgaaat caaaatgatt tgagaagtac 2280 aaataaaaga aagaaaggaa agaatgatat atgatattta ttggttgtag tacaggaaaa 2340 taatagttaa aatgatatcc cggattgatg gtcattacaa tgatcgtacc acaaaactct 2400 ttctaactca aattaaattg ttaaaattat ttttcaatac aaatttgata tatttttgtt 2460 ttttcgccga caagatgcat agatctttca tagaatctga aatctatatc ttttttatat 2520 tgcttttgag aagagtaaac cgatcatcat ctacgatcac tcctttttgt tctgtgtagg 2580 tatgaagaga gcaggtggga aggcagtgaa gtgaagtgaa gcatttgtcg catttgtgca 2640 gaattcccga cgtaattaat gtttaaagtc tgtgtgtgtg tatgtgtgcg aaggtttgta 2700 aactaggtca ctaggaagtt agccccttga cgaccatccc ctctcatcag cgcctcttca 2760 gcggcaactc tacgtcaaag gtgtcaactc gccaaatctg caaccacacc ttagttaagt 2820 gagccacccc gtagccacca aaattatcca cagcaccacc accttttatt cgtccttaac 2880 acaccgccat gattaacgcg cctcagtgcg attaactggc aaacaaattt ggagtgacgc 2940 tgcggcgatg tacatacata catatatgta tgcatgtttg tgctaaaccg acagcatttc 3000

221 cattcaataa cacacgcggc tcgtatgcaa acactgtaaa aaggttttat gctaaaaaag 3060 acgccgtatt tgtgcatgaa aaactgtcat tcatcatcca accaacacaa ataaccggta 3120 atggcatcgc cacattatgg ctttgtattt tttacatcct caaacacaaa aaaactttag 3180 ttgatttctg acttgcatcg cattcatcac ccactaaagt cgagcaatca atcctcaaaa 3240 tacgtatacg cactgttagt tcagttgatt aataggctaa ttatgaagga aactgaaagg 3300 aaacactaaa tcaataaatc ctggcaaatt agcatcagta tatatttgtg ttagtgcaaa 3360 catttaagtt ttctatcaat tttaaataca aatatgttca gaattaagat atatttcaaa 3420 gggaactatg ctttgtttaa ttaagattta aggttttata actataaaag ccttcaaaat 3480 gtgccatcta ttttatattc acttacaagc agatttcaat caagaccact ctttaatatg 3540 atatattatg tctagaacaa ccgagaaggc actcttaaat taaatatttt agtaccgtaa 3600 taaattatga aacgtgctga cggtaaaata tataatacaa ttcatacttt aagttatatt 3660 ttttttttgc cctatatggt tttacgtatc ggtgtgtatg tgagtacctc gcacacgcag 3720 gacatagaga taaaaaggct tctcccacat aaaagttcta ttctgttttt ttttttttat 3780 agaaaaatat tgctggcagg agtttagaac attgccaaag gggatgcgga cagatgaagg 3840 ggcgggggcg tggcgggtaa aagccataaa actcaggcgc cgaagcgcaa aatgcccttg 3900 ccctgaacaa aaagaagaaa ttgaacagca acaaccaaca acaaaaacaa agaagaacaa 3960 gagcaaataa aatacaaact gcttatttat ttatttgttt cgacaaatct caattgaaac 4020 aaagcttaaa agcttcgaaa tcaaaactta aatagaaacc acacagacat ccatccagac 4080 gaataaaacg aaaacgatag agcgcgagac aaagagacaa ttactattaa atccaagttc 4140 aattcggtcc gcaaacaatt gaatttgttg cagatttgat ttggcttcat gtggattgcg 4200 ataactattt tcctgggatt agtatgggat tggattcatt ggcccgaccg cagtttgctt 4260 cctaatgaga tttgcttaat taaaatgaaa ttcaataact ggaattccaa tgaatttaaa 4320 tgttagagaa aaactctaat tcggactttt gtggctagcc attatttgca gcaaggggga 4380 cataaaaagc atttggcttt cgtttggatt agtcagcaag gtcaaatctc gaaactgacc 4440 taagctaatg caaaatgact tttcctgtca atcacaatct atatttaatt caagcgaaat 4500 tctctgccac atttcttgcg ctataaatcg cagtacccat tatagcatat caacaaccaa 4560 attaagacga aagtacaata aaatgcaact aatttcagtt ttaataatgg atttgctggc 4620 ggcttatttt tgtttcaaat ttggttattt tctttagaaa tgtgcgcata cattaagacg 4680 aacacaaaaa ccagctttgg ctcaatctct taaaccttta aaacgttata tgtacgcaca 4740 tatttatgta cgaacaaatg aaggaaaatc tcaagcctaa ttccgcatta agctgcaagg 4800 aaacacataa cccaaaagta tgcaacataa ataaaattta aatcagcacg tttatgaagt 4860 ggattatttg aactgaaatg cttattcaac gttattagat gagatttatg gccaggagag 4920 catttgaatt ggcagattat tcgggccaac caagtaatgg ccactatatc aaacaaatca 4980 gttatccttc aattgcaaaa tacacagtgc agacaaatag tttaaactgt cttagtggta 5040 atcaaaatca actttaatta tcaactaatg tatgtgtatt ttacgaaaca aaagtgcatt 5100 atgcatgaac gaatgatagc aatatttttc aatataaaag cttacgattg ttttcctttt 5160 gttatcaatt atctatcaca ctccacagac atactcctag atcataataa taagttatat 5220 aaatatagca tagattttga aaggttaaaa ggttttctcc ccaccactcc ctctaataat 5280 attgtatata ataaaatata tatacaaatg tatttcataa tttcattgcc atccaattcc 5340 gcatagtatc tggtataccc catctgcaga aagacaccga agtgtataaa ttgcttacgt 5400 ttgcccatgt agtcataaaa attgctttgg cacataaaac gaagcttgac gctcgctttt 5460 ggttttggtt ttggttttgg cctggtctag tctggtttgg tttcatttgg ccccttaccg 5520 ttcttgtttc ctttggtttc catcgctggt gggcttgttt ttttgcgaga gtcctggccg 5580 tgtccttctt atatttctat ttctatttgt atttgtattt gtatttgtat tccccgattt 5640 gtattttgtt cgctcgccaa ttcggtaatc acatttcaag cgttttattc gtcctgattt 5700 catacgattg ctgattcaag tttctgtttg tggtccttgc cttgcaggat atgacaagtg 5760 atggtgctgt tacgttttgg atatttttgc tttgtttaat cgcctcgccg cacctgcaag 5820 ggggcgtggc cgggaggccc gatgaactgc acatcggcgg catctttccg atagccggca 5880 aaggaggatg gcagggcggc caggcgtgta tgcctgccgc aagactggcg ttggatgatg 5940 tcaacaagca gccaaatctg ctgccgggct tcaagctcat cctgcacagc aacgacagtg 6000 aggtgagtag tcagtacact gaaaaaaaaa cgatatatac ctaaggatat tttgaatgta 6060 atgcgatgca atagtcctac agtccaagtt cgatacgaaa atagtttttt atgtttcctc 6120 ttaagctggc tttaataaga ataaacattt attgaagctt ttgaactttc ttataatttt 6180 cataggtaac taatatatac aatatattac attaaatacc caataagtat ccaataaact 6240 tcgaagcaac acagaacttg tttgcaacac gattaatatc actgcaaata atatcctgac 6300 caaaaacccc tcctgatgca ctgagttctg tttaagcctt ctgttcacga agcattttcg 6360 ctcagtgcac tagtaagttg gaaagcgata agccctactt atatgcagcc cctgctgcct 6420 cctctgctgc catgccacat acccttgggt gccacttatt ttgtttcgtt tttgtttctg 6480 ctcactgatg agtagtggag tgctggctga gcgctggcat tcattagcat atttctctag 6540 gggatcaggc tggggctggg gctggagctg ggcactgtta acaaaggaca aacagtttta 6600

222 ttatgccgca ttaaagggta ttgctgcgcg tgtgttccac aaattgaatt cgccgcacaa 6660 tccgccgcat gtccaacaat atttggcaat gcctcggctt aatgactgca cataaattgc 6720 gattgagatt cgactggagc acgttcgaaa cgttaccaac agcaattata ttggctgagt 6780 tcggttaatc gggcttttat gtgcgtgatt cgtaattgat aaagggtatt tagcattaag 6840 aaaaatgtgt gtatatctcg aacaaggtcg cccaataaat gtcgcccggt gttcattaaa 6900 tcataaatgt atttacattt attcgtgtag tgcaacgctg taagtttaat tatttcaatg 6960 cgaaaatctc tcatttccca gaaagtttct atgagatcaa taagtaaaag tttttgctat 7020 aaacttcgaa cttggttttt tgcaatcaaa agttttacgc attttatctt taatgccagc 7080 agcagcacga actgaacttc tgcacaaagc ttttcttgaa taaatcggta taatcaaagt 7140 gaacacagta ttgatcatat tttttttatt gatccttata taaaattgtg aaatttttgc 7200 attttgtagc taacttaaag agcgcggaat atgtttttag ctggcatatt tgttctaaat 7260 ggaaaaaata gagcatgggc acgcaataaa tcaacatttc aatagtatcc agttgtctgg 7320 atgctgtaac ttctgttggc ttttagagaa ccagctatta aacaaatacc cgccctccaa 7380 acggtcatgc atcataataa atggccagta accgatgtag tttccgtttt ccagttccca 7440 accaagttgc gcgctatcaa tgccccttgg cgcgtatctc taatacaata catataaaac 7500 caaaaccaaa actatcttta tacattttca tatttcgcac atattttttg tttttttgtg 7560 aatttcgcat tttaagggtc tgcggtacag ttgttgcggt ttccactact tcggcggctg 7620 ttttgggcct gcctattttt aagcgcgaac ctcattagtt ttaagtgagc gaaagcttaa 7680 ctacttgttt tgagttttga atgaggtcac tttgccccgg ccgagccgta gctcatcatt 7740 tgagttattt ttattcaagg ctgccaggag ggacagtcac tactactaca tacatatatc 7800 ctacgaacat atacgaacat atacacgccc atttacgagc cagatacgga catatagata 7860 ggaacagagc cggagaggta aaccaagtcc tatccctggt catatctgtt cctatctggc 7920 gtggtctggt ctggtctggt ctggttagtt cagttcagtt cagttcgctt cgcttcgctg 7980 gactgagcct gagagccagg cgcgttatgt ttgtggctta ggcaaacagc ttccgttaaa 8040 tgctgcataa ttagttgcca tctccaggtc ccacagccac cttctcctcc ggcacatcca 8100 catccacact tactcccaca acgcaacgca ccaccccatc ccgcccacat ccacgtcact 8160 tggcaagcga caaggggcaa aggtcgcacg caatgtttgc ctttgccgct gccttttgct 8220 tgacctactt tgatgtgtga aatgtcccaa agaattctgc acaaaagcac tgagagttga 8280 acaaaaaaat gtataaacaa ggcaggttgg ttatcctgta ataagcgaaa tccctagtcg 8340 gcttaagtcc aagatcacac agaacaggtg aatacttttg tggcgaattt cgaatcgaac 8400 tttgattttt taatggccaa atataggtgc tgaaaaatcg tattattgca tttgcaaagc 8460 tgccactttc tatcggctaa gtgccttcat gcgaaccact gaaatggctt aaaccggttg 8520 tcaagcttta ggaataagcc ggaaattgat ttaacagcgt tgggataaaa atatgtgctc 8580 ctaaaaggtt tttgcttttt cttttttaat taaagtttaa ttaaatcaca acaaagcatt 8640 caattattta aactcacatt ttcaattgca atacagaaaa ggtaaatata atggctaagg 8700 taatcaaaaa ttatataaat aggcatctac agaatctgcg agttttaatt taaattgaat 8760 attgttttgt acaatgtaat aatattccta aatgtgcttt gtattataga agaacattct 8820 actaataaat catttagcta ttttttggtt aatattaaaa gtactatagt actatgtact 8880 atcagtttta tgctgcttag ttgttctata aaatcagtat gcctctgccc acgaaaaggg 8940 aaactattaa attagagcgg acatcgtggc atgcctcggt acccaaagcc aaagcacaca 9000 cccagatctg aatagatgga gtagtacgaa caggataata cttatgcata aacagggact 9060 ggacatgaga aggaaatgaa aggaaaaaaa aaaccaatta gaatggttgt ttacacgcaa 9120 accaagtaag aaatatgaaa attgtcgtca gaatggggtt tgggccaaag taaaggaaac 9180 gccgaacagg gaaacgagtt tgccatgtaa atgaatgaat gcgagaatga ataactgaat 9240 gaatgaatca tttatgtggc caatgtggat ggatacacgt atgcccacgt atgtatgtat 9300 gtatattcac aacttcggca caagggaaag ggacacacct tcgtgaatta ttcattgtca 9360 tgaatgaatc ttgtttaatt gataaatgct atgacatggg gattaatgaa aagcataatg 9420 gaaaaatatc aaccaggtgg cacataaatt aggcaggact tggaatatgg aaatttaact 9480 agctacataa atattgctac aaattcgtat aataaatcac gctaaatgca acaattaaca 9540 tgcatagttt aaaatttgat tgattataat tttcaatttt ctctgccagc aagtttttaa 9600 ttaagcagct taatttcgta gtttgctatg tcaaatccag cattccatcc agttgattaa 9660 ttttcatttt caattatatt ggcgaaaatt ggacgagatg acgaaaattc cttctgggcc 9720 agttttgtgc attaaattca atttaaaagc catgccaatg tcataaacgc cccgcatgaa 9780 tcacaaagcc aattaatcat atcaataatt atcttccaat gaagacagac acataaataa 9840 caggaaattc gctattaata actcctgaag ggtcgttgct tagcataatc ataatcaata 9900 catcgcgttg gccatcaaac gaaacctaca tatccgccca tgtttatgaa tatttatcga 9960 gcaccgacgg atgagagtat aagtattctt ggcaacttgg ctaattccgc tttccccatc 10020 cccatcccac cattttcatt cacagtgtga gcccggtttg ggcgccagcg tgatgtacaa 10080 tctgctctat aataaaccgc aaaagctgat gctgttggca ggatgcagca cggtctgcac 10140 cactgtagcc gaggctgcca aaatgtggaa tctaattgtg gtaagtgaaa tttgcatagc 10200

223 gccagaatgg ctggaatata tacatacata cttcgaaata ctttacctac atgccactgc 10260 ccctccacag ctctgctacg gggcctcgag tccggctctt tcggatcgca aacgattccc 10320 cactctattc cgcacccatc catcggccac ggtgcacaat ccaacgcgca tcaagctgat 10380 gaagaaattc ggctggtccc gggtggccat tctgcagcag gcggaggagg tctttatatc 10440 ggtaggtaat cggtgctaac taattacatt tccatattaa cttcgaaaac ttttatgaac 10500 agaccgtaga ggatctcgag aatcgatgca tggaggctgg cgttgaaatc gtaactagac 10560 aatcatttct atccgatcca acagacgccg tgcgcaattt gcgacgccag gatgcacgca 10620 tcattgtggg actcttctat gtggtggccg ccaggagggt gctctgcgaa atgtacaaac 10680 agcagctata tggccgagct catgtgtggt tctttattgg taaatacaaa ttatactact 10740 tagataccga tatctcatat gcatagatac tttcacagag tcttcttgta actaaactac 10800 ttttttttta ggctggtacg aggacaactg gtacgaggtg aatctgaaag cagagggcat 10860 cacctgcact gttgaacaga tgcgaatagc tgccgaagga catctgacaa cggaagcgct 10920 catgtggaat cagaacaatc agacaactat atccggaatg actgcagagg aatttcggtt 10980 agtactacta ctctatccat tgctaaagtt tttgcttcaa tgtgccttct ttttgcgcag 11040 acatcgactg aatcaggcgc taatcgagga gggttacgac attaaccacg atcgctatcc 11100 ggagggatat caggaggcgc cactcgccta cgatgcagtg tggagtgtgg ctttggcttt 11160 caacaagacc atggaacgat tgacaaccgg gaagaaatct ctgagggatt ttacctatac 11220 ggacaaggag attgccgatg aaatctacgc tgccatgaac tccacacaat ttctgggtgt 11280 atcggtcagt ttgtgaaact aatttcataa tacttagtta gttacttatt tttttatttg 11340 cagggtgtgg tggcattcag ttctcagggc gatcgtattg ctcttacaca gatcgaacag 11400 atgatagacg gcaagtacga gaagttgggt tactacgata ctcagttgga taacctatcc 11460 tggttgaata ctgaacagtg gattggtggc aaggtaagca aatcagttag cgttgaaaaa 11520 acaatcatat aatcaaaatg tcggacgatg ataaaaatca aaagaagaca aagcatgtaa 11580 cgactgaacc gaataagaac ggaaatccgt ccaaagacga cgttaataca agaggatcat 11640 taacaagctt aagtgagaaa aatgatgaat ccaaaaatcc atcatcatct gcaagtcttc 11700 agcaagctcc taaggtagca ccaaaaccga aaaagttatc aatttcggat gctggtaaag 11760 acacagtaac ccaaaaagtc aaagaaaatg aagagccagg attttctaaa caatttgaaa 11820 aagaatctat tggtgtgcga gcaaatagaa acagcagtgc aacaaaaaag gaaaatgaaa 11880 agctattagt aaagaccgtg cccggaaaat ctcttataaa agaatctaac gatgaaaatg 11940 tggaaccatc tagacgcaca aaaagtcagc cagttggaaa aaaagtttac gaggaatctt 12000 caacgaggcg agttcgtgag ccatttgatt cttttgatag ggaaaagtac ctgtctgata 12060 tgatcgatta tgatcgatcg tccgaggacg tgccggaaaa aaaactatct tgggaaccag 12120 acagtacact tcgacgtcgt tttgtcagca ataatgaata tcattctagt cttgaaggtg 12180 aggaggaaga gatcgattta gattcagttg gatcgtcaac aatgcgaggt agctatcgaa 12240 tgccacagaa tgccgaggat gaacgacctg ttatcctagc tgaaataatc aatatgggaa 12300 agttgaagga gctcaaggag caacgcgaat caactaacgt atttcgtaac aatcgtagag 12360 atgataaaac cattgatgaa gtgaagggtt ccaagatcac aggaaccagc aaacaacatg 12420 ttgaagaagt taaatataat gaaacagcaa gtaatgaaga tgatgacaat gcacaggtaa 12480 aacatatagg tacaatcaca aaaatcttta gcattgcgca aagaatgaaa gagaagaaaa 12540 gctccaaaga aagtgaagaa gacgagaata aggacgagaa taaagatgta aaaaaagatg 12600 aaaataaaga cgatgaacag aaacttcccc cggaaccaga gatcgaattg gaggccaaaa 12660 aagcttggac ttttccgatc gcagagacat cacctgatat ccctggagaa aatcagatcc 12720 tgcaagaata ccaaaaggtt aaaattggca aaagaaacag gaaatacaga tgtataggca 12780 tcaatacgga tataagcaga aaatctaaga ttaaaacatt tatcagcaag tctgcaggtg 12840 atgacttagt agtataccat gatggtggaa gattgcgaga tataggacaa accactgaaa 12900 atcttaagaa tcaacgaaag aatcataaac acaaaaccga accagatgat atacccgttg 12960 atataggaca cagcgatgat cgagtaaggg aaattggagt gaatactaaa aagttaccaa 13020 aaatcataat accaccaatt gccgagatgc atgtgcacaa aaatggcaaa ttaagggaca 13080 ttggaaccag cacagataag ccattttggc caatcgatga cggaactgat gtaatctaca 13140 tgcatcccat taagactgat aggaagaaat taaacaaact gattgtggat ccaccgccgg 13200 ataatggacc ctacaagatg ccaaccaaag aagatagacg aacgtactac aaaggttgtg 13260 aatatcattt tcctggccga acggaatggc gcaggctttt cttcaacaaa atccatggaa 13320 aatacaagct acgccgtcca agtcattggc tctacacact agttttttcc gttttatata 13380 ttttgtttgt cattatcttt tccatggcct ggttcgattt catcaaagat gacgcttcca 13440 gaaaggtacc catgataaag atggcacaac catttattag tttcactccc atcggaccac 13500 gaactaatcc caaggcggta tcctttgatc ctagaaacag cacagaagtc atggaaaagt 13560 acgctggtat aatggctctt ctggaaaaat acggcgacta tggacacaat ccgcgttttg 13620 gaacgtgtac tgcgaatgaa aagtttggct atccaagcgg cgaaccgtgt gtttttctta 13680 aagttaatcg gattattgga tttaagaccg aaccctacat caattccgat gagcttgtca 13740 aagccaagat cgatgaggtt gaatttacgg ccttaaaaag gttattggaa aatacaacaa 13800

224 cagaggaggg tcatttgaat cgcacttgga taacatgccg ttcagataaa gataagaatg 13860 ttttgattga atttcatcca gagccggcga taagaacgga atacaccgat attgaagaga 13920 aaatcgagta tattgcgaac gagggtaaaa agtcattttt cggcccaaac gatgtgaatc 13980 gaatcgtggc tcttaagatc aaaaatctca aagcaaatga acgtgtccat ataaattgca 14040 aaatgtgggc tcagaatata catcatagga aagagggtta tggccaagtt tcgttttttg 14100 tgttattagc tacaaatgaa aaccgcgaga gggtggaaaa attactccga accgactact 14160 cattataaaa tacataaata taactttcta ataaaatgtg ttatatgata tatgtatgta 14220 ttatttataa catctataat ccaggttcct caagatcgca caattgtcac ccatgttcta 14280 cgcaccgtgt ccttgccatt atttgtgtgc atgtgcacaa tatccagttg tggcatattc 14340 gttgccttcg ccttgatcat ctttaatata tggaataagc atagaaggta actatttaat 14400 tggtagtgct cgtgcagaac taactaaggg ttatataatt tctagagtaa tacaatcctc 14460 gcatcccgtt tgcaatacga tcatgttatt tggtgtcatc atctgtctaa tatctgtcat 14520 cttactgggc atcgacggac gctttgtcag ccccgaggaa tatccaaagg tgcgagttac 14580 ttaccttaaa agttctcttc atttttatta aagttaattt gatataaaat tatccattag 14640 atatgtcaag cgcgggcttg gttactatcc accggtttta cactagcata cggtgctatg 14700 ttcagcaagg tctggcgtgt gcatcgtttt acaacaaaag caaaaactga cccaaaggtg 14760 ggtttaaatt aaattaacta caactatata ttagttgcta atcattttgt ggaattgcag 14820 aaaaaagtgg aaccttggaa gctatacacc atggtttcgg ggctattatc aatagattta 14880 gtgatattac tctcatggca gatctttgat ccgctgcagc gttatctcga aacattccca 14940 ctcgaagatc cagtatctac tactgatgat attaaaatac gtccagagct tgagcattgt 15000 gaaagtcaac gcaactccat gtggttgggt atgttgtgat aacgatccat tatattgtat 15060 ataatatatt tatattattt tgcaggtctt gtatacggct tcaaggggct aatcctggtg 15120 tttggcctct ttttggcgta cgagacgcgc tccattaaag tgaaacagat caacgattcg 15180 cgttatgtgg gcatgagcat ctataacgtg gtcgtccttt gcctgataac agctccggtg 15240 ggcatggtca ttgcatcgca acaggacgcg tcctttgcct tcgttgctct agctgtgata 15300 ttctgttgtt tcctaagcat gctgctgata tttgtgccaa aggtcagcca ctacactgaa 15360 ctaaaagaag tagcacattt gtaatgatct ctattcgcac aggtcattga ggttatacgt 15420 catcccaagg ataaggccga atcgaaatac aatcccgatt cagccatatc gaaagaggac 15480 gaagaacgct atcagaaact tgttaccgaa aacgaggaat tgcaacgatt aataacacag 15540 gtatgctgaa ttatggtaga ttatcttaat aaaatcgtat tttatttaat tttgtttaaa 15600 gattaaattc aactgttcgt tgaacgttaa tctaaaagta tttcggtctt atcataattt 15660 gaacaaaagt taaggattgg aatttccagc ggccccagtg aattccattc agcatgccgg 15720 tttcaccttc tctaaaataa agtccattta gcgagctgca atatgaagta ttatcaacct 15780 cttataaatc aaattttaat ttgataatta atttaccttg acaaacatga gtgaaaccac 15840 caaccaccgc catgctcggc tgcacaattt ttactagatt catcattatc acgatcaaaa 15900 gttgagaacc ttttatttat atggtatctt agggagtccc cagctgttcc agaatatttt 15960 cccacccgtt ccagtttgta taattcagtt tcactgtcca cttgaaagtc atcaaagtga 16020 gcgtatactg tagcgccagg accatgcttc aattgaatga aaagttcgtg tggttgttct 16080 ctagtcatta ggtaaagctt ctgaagaccg atgaaaaatt cgccattcgg atcgccaaat 16140 ccatctttgt aactaaacca cgattggtta aaattaacac ttccatctag tcgtctttga 16200 atgacaatcc aatctcttgc cgtcgttttg cactgggtca cttgaaaagg ttcttcttct 16260 ggcaacatta gctggtgaat tccatttgga ctgccactag gacacgtgtg tggtgaactc 16320 tggcccactt cgaacagcaa agtccataaa aatagtacaa aaaagcacga tttcattgta 16380 ctcgacatgc gtactgttag aagatcggtg gcttactgaa gtatctacca tttaaaaggg 16440 gaacattggg acgcagtttt gtggttttgc tacctttgac cgcattgctt gatatgcata 16500 tattctattt aggtcggcat ttaagcaaat ggattccaaa aaagtgaatg gagactattt 16560 aaaagataga actacatttt tattgtttaa atgtttgttt gttttgctta tatttttatt 16620 gttttataaa cattgattta ttaattttcc gcttgcagaa ggaggaaaag attcgagtcc 16680 tgcgacagcg tctggtggag cggggcgacg ccaagggcac agaactgaat ggtgcaacag 16740 gtgtcgcctc cgccgccgtt gcaacaactt cgcagcccgc ttccctcatc aactcatcag 16800 cacatgccac gcccgcagcc acactcgcaa tcacacaagg tgagtagagt acctggtgca 16860 tggaactatg catcccaaat gccccttagc cagttgcatg tggtaatcga tactagttac 16920 gttggtttag cttgacgttc ttaatcgtta tgttctcgat tttaactaga aatcttagct 16980 ctattcgtcg gcattgacac aattgattag gaacaacaat ataaatggag ttcaaaggtt 17040 atttgcttat gctaacgcta tgtaaactcg attttcgcac aaaaaaccaa aggcaattta 17100 tcagtttctg gaatgtctat tgctttgtgt gcatacatat gtatcttaag cacttttgca 17160 gtttttgagc ttatttatat cttcagcact ttagcacttt tttaataaat atcactgctt 17220 ctgcaccctt ttttcacatt ttagcaagat tattcaaaac atactaatac gtaatatatt 17280 tatcttacag atactcatga gcatcgtaca tgaaaaaact tgtcaatttc ctttgcgtga 17340 taggtgaatt atacaaaaga tatgaaatgc aaataatgat gctaacggaa ggatggattt 17400

225 aaacaaacac gtacttaaag aactttgtat caactttaag ctgagctaaa taagtgaatt 17460 ggtagcagca attttgtaga ataatgaaat atgtattgta ccttaaacgt gtttagcatt 17520 aatattgaaa acgaagtaat tttaacttaa aagaaaacaa aacaaaaatt cgacactagc 17580 atctaaacta agcgaattgt taggctttaa agttgcaaca cagaaaccaa aaaaaattct 17640 agcaaatcaa gagaattcat tacgaaaaga tcgtgttaaa gttagtaatt tttaaatgca 17700 ggtagagaag acaaattgtt gattttgtgt ttagtaaata ctgttttttt agttaaacga 17760 attatccttt cgaacctcat ttgctcagcg ctgtctccta gagctctcta gttaattata 17820 tctgcgtaga tgaaaattcc ccaaaag 17847

<210> 176 <211> 5167 <212> DNA <213> Drosophila

<400> 176 tcatggagtt ccagtcgtcg gatacatgtg gaacacaacg aacacagcag gagcctctcg 60 cgtctcatcc cccgaataca atgcgaaaaa aactgaatac ctgcaaaaag aaatacgcgt 120 taaatggaat tacgcacccc ctccatccaa caccccctac gaccctgccc aagcaaaagg 180 agcagcgaaa aagaagaagc gtcttatgaa acaattgaag caccggccaa aggagcaaag 240 gagcagacaa agacagagac aaaaacatcg gcaaaggata aaacggaggc cgagaagaag 300 aggaagcagt agtagcaaag caggaaacaa caacaacaac aaccgcaaca tcgcattttt 360 aaacggcaat acgcaaaaaa aatattgctg gcaggagttt agaacattgc caaaggggat 420 gcggacagat gaaggggcgg gggcgtggcg ggatatgaca agtgatggtg ctgttacgtt 480 ttggatattt ttgctttgtt taatcgcctc gccgcacctg caagggggcg tggccgggag 540 gcccgatgaa ctgcacatcg gcggcatctt tccgatagcc ggcaaaggag gatggcaggg 600 cggccaggcg tgtatgcctg ccgcaagact ggcgttggat gatgtcaaca agcagccaaa 660 tctgctgccg ggcttcaagc tcatcctgca cagcaacgac agtgagtgtg agcccggttt 720 gggcgccagc gtgatgtaca atctgctcta taataaaccg caaaagctga tgctgttggc 780 aggatgcagc acggtctgca ccactgtagc cgaggctgcc aaaatgtgga atctaattgt 840 gctctgctac ggggcctcga gtccggctct ttcggatcgc aaacgattcc ccactctatt 900 ccgcacccat ccatcggcca cggtgcacaa tccaacgcgc atcaagctga tgaagaaatt 960 cggctggtcc cgggtggcca ttctgcagca ggcggaggag gtctttatat cgaccgtaga 1020 ggatctcgag aatcgatgca tggaggctgg cgttgaaatc gtaactagac aatcatttct 1080 atccgatcca acagacgccg tgcgcaattt gcgacgccag gatgcacgca tcattgtggg 1140 actcttctat gtggtggccg ccaggagggt gctctgcgaa atgtacaaac agcagctata 1200 tggccgagct catgtgtggt tctttattgg ctggtacgag gacaactggt acgaggtgaa 1260 tctgaaagca gagggcatca cctgcactgt tgaacagatg cgaatagctg ccgaaggaca 1320 tctgacaacg gaagcgctca tgtggaatca gaacaatcag acaactatat ccggaatgac 1380 tgcagaggaa tttcggttag tactactact ctatccattg ctaaagtttt tgcttcaatg 1440 tgccttcttt ttgcgcagac atcgactgaa tcaggcgcta atcgaggagg gttacgacat 1500 taaccacgat cgctatccgg agggatatca ggaggcgcca ctcgcctacg atgcagtgtg 1560 gagtgtggct ttggctttca acaagaccat ggaacgattg acaaccggga agaaatctct 1620 gagggatttt acctatacgg acaaggagat tgccgatgaa atctacgctg ccatgaactc 1680 cacacaattt ctgggtgtat cgggtgtggt ggcattcagt tctcagggcg atcgtattgc 1740 tcttacacag atcgaacaga tgatagacgg caagtacgag aagttgggtt actacgatac 1800 tcagttggat aacctatcct ggttgaatac tgaacagtgg attggtggca agaagacaaa 1860 gcatgtaacg actgaaccga ataagaacgg aaatccgtcc aaagacgacg ttaatacaag 1920 aggatcatta acaagcttaa gtgagaaaaa tgatgaatcc aaaaatccat catcatctgc 1980 aagtcttcag caagctccta aggtagcacc aaaaccgaaa aagttatcaa tttcggatgc 2040 tggtaaagac acagtaaccc aaaaagtcaa agaaaatgaa gagccaggat tttctaaaca 2100 atttgaaaaa gaatctattg gtgtgcgagc aaatagaaac agcagtgcaa caaaaaagga 2160 aaatgaaaag ctattagtaa agaccgtgcc cggaaaatct cttataaaag aatctaacga 2220 tgaaaatgtg gaaccatcta gacgcacaaa aagtcagcca gttggaaaaa aagtttacga 2280 ggaatcttca acgaggcgag ttcgtgagcc atttgattct tttgataggg aaaagtacct 2340 gtctgatatg atcgattatg atcgatcgtc cgaggacgtg ccggaaaaaa aactatcttg 2400 ggaaccagac agtacacttc gacgtcgttt tgtcagcaat aatgaatatc attctagtct 2460 tgaaggtgag gaggaagaga tcgatttaga ttcagttgga tcgtcaacaa tgcgaggtag 2520 ctatcgaatg ccacagaatg ccgaggatga acgacctgtt atcctagctg aaataatcaa 2580

226 tatgggaaag ttgaaggagc tcaaggagca acgcgaatca actaacgtat ttcgtaacaa 2640 tcgtagagat gataaaacca ttgatgaagt gaagggttcc aagatcacag gaaccagcaa 2700 acaacatgtt gaagaagtta aatataatga aacagcaagt aatgaagatg atgacaatgc 2760 acaggtaaaa catataggta caatcacaaa aatctttagc attgcgcaaa gaatgaaaga 2820 gaagaaaagc tccaaagaaa gtgaagaaga cgagaataag gacgagaata aagatgtaaa 2880 aaaagatgaa aataaagacg atgaacagaa acttcccccg gaaccagaga tcgaattgga 2940 ggccaaaaaa gcttggactt ttccgatcgc agagacatca cctgatatcc ctggagaaaa 3000 tcagatcctg caagaatacc aaaaggttaa aattggcaaa agaaacagga aatacagatg 3060 tataggcatc aatacggata taagcagaaa atctaagatt aaaacattta tcagcaagtc 3120 tgcaggtgat gacttagtag tataccatga tggtggaaga ttgcgagata taggacaaac 3180 cactgaaaat cttaagaatc aacgaaagaa tcataaacac aaaaccgaac cagatgatat 3240 acccgttgat ataggacaca gcgatgatcg agtaagggaa attggagtga atactaaaaa 3300 gttaccaaaa atcataatac caccaattgc cgagatgcat gtgcacaaaa atggcaaatt 3360 aagggacatt ggaaccagca cagataagcc attttggcca atcgatgacg gaactgatgt 3420 aatctacatg catcccatta agactgatag gaagaaatta aacaaactga ttgtggatcc 3480 accgccggat aatggaccct acaagatgcc aaccaaagaa gatagacgaa cgtactacaa 3540 aggttgtgaa tatcattttc ctggccgaac ggaatggcgc aggcttttct tcaacaaaat 3600 ccatggaaaa tacaagctac gccgtccaag tcattggctc tacacactag ttttttccgt 3660 tttatatatt ttgtttgtca ttatcttttc catggcctgg ttcgatttca tcaaagatga 3720 cgcttccaga aaggtaccca tgataaagat ggcacaacca tttattagtt tcactcccat 3780 cggaccacga actaatccca aggcggtatc ctttgatcct agaaacagca cagaagtcat 3840 ggaaaagtac gctggtataa tggctcttct ggaaaaatac ggcgactatg gacacaatcc 3900 gcgttttgga acgtgtactg cgaatgaaaa gtttggctat ccaagcggcg aaccgtgtgt 3960 ttttcttaaa gttaatcgga ttattggatt taagaccgaa ccctacatca attccgatga 4020 gcttgtcaaa gccaagatcg atgaggttga atttacggcc ttaaaaaggt tattggaaaa 4080 tacaacaaca gaggagggtc atttgaatcg cacttggata acatgccgtt cagataaaga 4140 taagaatgtt ttgattgaat ttcatccaga gccggcgata agaacggaat acaccgatat 4200 tgaagagaaa atcgagtata ttgcgaacga gggtaaaaag tcatttttcg gcccaaacga 4260 tgtgaatcga atcgtggctc ttaagatcaa aaatctcaaa gcaaatgaac gtgtccatat 4320 aaattgcaaa atagtaatac aatcctcgca tcccgtttgc aatacgatca tgttatttgg 4380 tgtcatcatc tgtctaatat ctgtcatctt actgggcatc gacggacgct ttgtcagccc 4440 cgaggaatat ccaaagatct ttgatccgct gcagcgttat ctcgaaacat tcccactcga 4500 agatccagta tctactactg atgatattaa aatacgtcca gagcttgagc attgtgaaag 4560 tcaacgcaac tccatgtggt tgggtcttgt atacggcttc aaggggctaa tcctggtgtt 4620 tggcctcttt ttggcgtacg agacgcgctc cattaaagtg aaacagatca acgattcgcg 4680 ttatgtgggc atgagcatct ataacgtggt cgtcctttgc ctgataacag ctccggtggg 4740 catggtcatt gcatcgcaac aggacgcgtc ctttgccttc gttgctctag ctgtgatatt 4800 ctgttgtttc ctaagcatgc tgctgatatt tgtgccaaag gtcattgagg ttatacgtca 4860 tcccaaggat aaggccgaat cgaaatacaa tcccgattca gccatatcga aagaggacga 4920 agaacgctat cagaaacttg ttaccgaaaa cgaggaattg caacgattaa taacacagaa 4980 ggaggaaaag attcgagtcc tgcgacagcg tctggtggag cggggcgacg ccaagggcac 5040 agaactgaat ggtgcaacag gtgtcgcctc cgccgccgtt gcaacaactt cgcagcccgc 5100 ttccctcatc aactcatcag cacatgccac gcccgcagcc acactcgcaa tcacacaagg 5160 tgagtag 5167

<210> 177 <211> 1713 <212> PRT <213> Drosophila

<400> 177

Met Trp Asn Thr Thr Asn Thr Ala Gly Ala Ser Arg Val Ser Ser Pro

1 5 10 15

Glu Tyr Asn Ala Lys Lys Thr Glu Tyr Leu Gin Lys Glu He Arg Val

20 25 30

Lys Trp Asn Tyr Ala Pro Pro Pro Ser Asn Thr Pro Tyr Asp Pro Ala

35 40 45

Gin Ala Lys Gly Ala Ala Lys Lys Lys Lys Arg Leu Met Lys Gin Leu

227 50 55 60

Lys His Arg Pro Lys Glu Gin Arg Ser Arg Gin Arg Gin Arg Gin Lys 65 70 75 80

His Arg Gin Arg He Lys Arg Arg Pro Arg Arg Arg Gly Ser Ser Ser

85 90 95

Ser Lys Ala Gly Asn Asn Asn Asn Asn Asn Arg Asn He Ala Phe Leu

100 105 110

Asn Gly Asn Thr Gin Lys Lys Tyr Cys Trp Gin Glu Phe Arg Thr Leu

115 120 125

Pro Lys Gly Met Arg Thr Asp Glu Gly Ala Gly Ala Trp Arg Asp Met

130 135 140

Thr Ser Asp Gly Ala Val Thr Phe Trp He Phe Leu Leu Cys Leu He 145 150 155 160

Ala Ser Pro His Leu Gin Gly Gly Val Ala Gly Arg Pro Asp Glu Leu

165 170 175

His He Gly Gly He Phe Pro He Ala Gly Lys Gly Gly Trp Gin Gly

180 185 190

Gly Gin Ala Cys Met Pro Ala Ala Arg Leu Ala Leu Asp Asp Val Asn

195 200 205

Lys Gin Pro Asn Leu Leu Pro Gly Phe Lys Leu He Leu His Ser Asn

210 215 220

Asp Ser Glu Cys Glu Pro Gly Leu Gly Ala Ser Val Met Tyr Asn Leu 225 230 235 240

Leu Tyr Asn Lys Pro Gin Lys Leu Met Leu Leu Ala Gly Cys Ser Thr

245 250 255

Val Cys Thr Thr Val Ala Glu Ala Ala Lys Met Trp Asn Leu He Val

260 265 270

Leu Cys Tyr Gly Ala Ser Ser Pro Ala Leu Ser Asp Arg Lys Arg Phe

275 280 285

Pro Thr Leu Phe Arg Thr His Pro Ser Ala Thr Val His Asn Pro Thr

290 295 300

Arg He Lys Leu Met Lys Lys Phe Gly Trp Ser Arg Val Ala He Leu 305 310 315 320

Gin Gin Ala Glu Glu Val Phe He Ser Thr Val Glu Asp Leu Glu Asn

325 330 335

Arg Cys Met Glu Ala Gly Val Glu He Val Thr Arg Gin Ser Phe Leu

340 345 350

Ser Asp Pro Thr Asp Ala Val Arg Asn Leu Arg Arg Gin Asp Ala Arg

355 360 365

He He Val Gly Leu Phe Tyr Val Val Ala Ala Arg Arg Val Leu Cys

370 375 380

Glu Met Tyr Lys Gin Gin Leu Tyr Gly Arg Ala His Val Trp Phe Phe 385 390 395 400

He Gly Trp Tyr Glu Asp Asn Trp Tyr Glu Val Asn Leu Lys Ala Glu

405 410 415

Gly He Thr Cys Thr Val Glu Gin Met Arg He Ala Ala Glu Gly His

420 425 430

Leu Thr Thr Glu Ala Leu Met Trp Asn Gin Asn Asn Gin Thr Thr He

435 440 445

Ser Gly Met Thr Ala Glu Glu Phe Arg Leu Val Leu Leu Leu Tyr Pro

450 455 460

Leu Leu Lys Phe Leu Leu Gin Cys Ala Phe Phe Leu Arg Arg His Arg 465 470 475 480

Leu Asn Gin Ala Leu He Glu Glu Gly Tyr Asp He Asn His Asp Arg

485 490 495

Tyr Pro Glu Gly Tyr Gin Glu Ala Pro Leu Ala Tyr Asp Ala Val Trp

500 505 510

Ser Val Ala Leu Ala Phe Asn Lys Thr Met Glu Arg Leu Thr Thr Gly

515 520 525

Lys Lys Ser Leu Arg Asp Phe Thr Tyr Thr Asp Lys Glu He Ala Asp

228 530 535 540

Glu He Tyr Ala Ala Met Asn Ser Thr Gin Phe Leu Gly Val Ser Gly 545 550 555 560

Val Val Ala Phe Ser Ser Gin Gly Asp Arg He Ala Leu Thr Gin He

565 570 575

Glu Gin Met He Asp Gly Lys Tyr Glu Lys Leu Gly Tyr Tyr Asp Thr

580 585 590

Gin Leu Asp Asn Leu Ser Trp Leu Asn Thr Glu Gin Trp He Gly Gly

595 600 605

Lys Lys Thr Lys His Val Thr Thr Glu Pro Asn Lys Asn Gly Asn Pro

610 615 620

Ser Lys Asp Asp Val Asn Thr Arg Gly Ser Leu Thr Ser Leu Ser Glu 625 630 635 640

Lys Asn Asp Glu Ser Lys Asn Pro Ser Ser Ser Ala Ser Leu Gin Gin

645 650 655

Ala Pro Lys Val Ala Pro Lys Pro Lys Lys Leu Ser He Ser Asp Ala

660 665 670

Gly Lys Asp Thr Val Thr Gin Lys Val Lys Glu Asn Glu Glu Pro Gly

675 680 685

Phe Ser Lys Gin Phe Glu Lys Glu Ser He Gly Val Arg Ala Asn Arg

690 695 700

Asn Ser Ser Ala Thr Lys Lys Glu Asn Glu Lys Leu Leu Val Lys Thr 705 710 715 720

Val Pro Gly Lys Ser Leu He Lys Glu Ser Asn Asp Glu Asn Val Glu

725 730 735

Pro Ser Arg Arg Thr Lys Ser Gin Pro Val Gly Lys Lys Val Tyr Glu

740 745 750

Glu Ser Ser Thr Arg Arg Val Arg Glu Pro Phe Asp Ser Phe Asp Arg

755 760 765

Glu Lys Tyr Leu Ser Asp Met He Asp Tyr Asp Arg Ser Ser Glu Asp

770 775 780

Val Pro Glu Lys Lys Leu Ser Trp Glu Pro Asp Ser Thr Leu Arg Arg 785 790 795 800

Arg Phe Val Ser Asn Asn Glu Tyr His Ser Ser Leu Glu Gly Glu Glu

805 810 815

Glu Glu He Asp Leu Asp Ser Val Gly Ser Ser Thr Met Arg Gly Ser

820 825 830

Tyr Arg Met Pro Gin Asn Ala Glu Asp Glu Arg Pro Val He Leu Ala

835 840 845

Glu He He Asn Met Gly Lys Leu Lys Glu Leu Lys Glu Gin Arg Glu

850 855 860

Ser Thr Asn Val Phe Arg Asn Asn Arg Arg Asp Asp Lys Thr He Asp 865 870 875 880

Glu Val Lys Gly Ser Lys He Thr Gly Thr Ser Lys Gin His Val Glu

885 890 895

Glu Val Lys Tyr Asn Glu Thr Ala Ser Asn Glu Asp Asp Asp Asn Ala

900 905 910

Gin Val Lys His He Gly Thr He Thr Lys He Phe Ser He Ala Gin

915 920 925

Arg Met Lys Glu Lys Lys Ser Ser Lys Glu Ser Glu Glu Asp Glu Asn

930 935 940

Lys Asp Glu Asn Lys Asp Val Lys Lys Asp Glu Asn Lys Asp Asp Glu 945 950 955 960

Gin Lys Leu Pro Pro Glu Pro Glu He Glu Leu Glu Ala Lys Lys Ala

965 970 975

Trp Thr Phe Pro He Ala Glu Thr Ser Pro Asp He Pro Gly Glu Asn

980 985 990

Gin He Leu Gin Glu Tyr Gin Lys Val Lys He Gly Lys Arg Asn Arg

995 1000 1005

Lys Tyr Arg Cys He Gly He Asn Thr Asp He Ser Arg Lys Ser Lys

229 1010 1015 1020

He Lys Thr Phe He Ser Lys Ser Ala Gly Asp Asp Leu Val Val Tyr 1025 1030 1035 1040

His Asp Gly Gly Arg Leu Arg Asp He Gly Gin Thr Thr Glu Asn Leu

1045 1050 1055

Lys Asn Gin Arg Lys Asn His Lys His Lys Thr Glu Pro Asp Asp He

1060 1065 1070

Pro Val Asp He Gly His Ser Asp Asp Arg Val Arg Glu He Gly Val

1075 1080 1085

Asn Thr Lys Lys Leu Pro Lys He He He Pro Pro He Ala Glu Met

1090 1095 1100

His Val His Lys Asn Gly Lys Leu Arg Asp He Gly Thr Ser Thr Asp 1105 1110 1115 1120

Lys Pro Phe Trp Pro He Asp Asp Gly Thr Asp Val He Tyr Met His

1125 1130 1135

Pro He Lys Thr Asp Arg Lys Lys Leu Asn Lys Leu He Val Asp Pro

1140 1145 1150

Pro Pro Asp Asn Gly Pro Tyr Lys Met Pro Thr Lys Glu Asp Arg Arg

1155 1160 1165

Thr Tyr Tyr Lys Gly Cys Glu Tyr His Phe Pro Gly Arg Thr Glu Trp

1170 1175 1180

Arg Arg Leu Phe Phe Asn Lys He His Gly Lys Tyr Lys Leu Arg Arg 1185 1190 1195 1200

Pro Ser His Trp Leu Tyr Thr Leu Val Phe Ser Val Leu Tyr He Leu

1205 1210 1215

Phe Val He He Phe Ser Met Ala Trp Phe Asp Phe He Lys Asp Asp

1220 1225 1230

Ala Ser Arg Lys Val Pro Met He Lys Met Ala Gin Pro Phe He Ser

1235 1240 1245

Phe Thr Pro He Gly Pro Arg Thr Asn Pro Lys Ala Val Ser Phe Asp

1250 1255 1260

Pro Arg Asn Ser Thr Glu Val Met Glu Lys Tyr Ala Gly He Met Ala 1265 1270 1275 1280

Leu Leu Glu Lys Tyr Gly Asp Tyr Gly His Asn Pro Arg Phe Gly Thr

1285 1290 1295

Cys Thr Ala Asn Glu Lys Phe Gly Tyr Pro Ser Gly Glu Pro Cys Val

1300 1305 1310

Phe Leu Lys Val Asn Arg He He Gly Phe Lys Thr Glu Pro Tyr He

1315 1320 1325

Asn Ser Asp Glu Leu Val Lys Ala Lys He Asp Glu Val Glu Phe Thr

1330 1335 1340

Ala Leu Lys Arg Leu Leu Glu Asn Thr Thr Thr Glu Glu Gly His Leu 1345 1350 1355 1360

Asn Arg Thr Trp He Thr Cys Arg Ser Asp Lys Asp Lys Asn Val Leu

1365 1370 1375

He Glu Phe His Pro Glu Pro Ala He Arg Thr Glu Tyr Thr Asp He

1380 1385 1390

Glu Glu Lys He Glu Tyr He Ala Asn Glu Gly Lys Lys Ser Phe Phe

1395 1400 1405

Gly Pro Asn Asp Val Asn Arg He Val Ala Leu Lys He Lys Asn Leu

1410 1415 1420

Lys Ala Asn Glu Arg Val His He Asn Cys Lys He Val He Gin Ser 1425 1430 1435 1440

Ser His Pro Val Cys Asn Thr He Met Leu Phe Gly Val He He Cys

1445 1450 1455

Leu He Ser Val He Leu Leu Gly He Asp Gly Arg Phe Val Ser Pro

1460 1465 1470

Glu Glu Tyr Pro Lys He Phe Asp Pro Leu Gin Arg Tyr Leu Glu Thr

1475 1480 1485

Phe Pro Leu Glu Asp Pro Val Ser Thr Thr Asp Asp He Lys He Arg

230 1490 1495 1500

Pro Glu Leu Glu His Cys Glu Ser Gin Arg Asn Ser Met Trp Leu Gly 1505 1510 1515 1520

Leu Val Tyr Gly Phe Lys Gly Leu He Leu Val Phe Gly Leu Phe Leu

1525 1530 1535

Ala Tyr Glu Thr Arg Ser He Lys Val Lys Gin He Asn Asp Ser Arg

1540 1545 1550

Tyr Val Gly Met Ser He Tyr Asn Val Val Val Leu Cys Leu He Thr

1555 1560 1565

Ala Pro Val Gly Met Val He Ala Ser Gin Gin Asp Ala. Ser Phe Ala

1570 1575 1580

Phe Val Ala Leu Ala Val He Phe Cys Cys Phe Leu Ser Met Leu Leu 1585 1590 1595 1600

He Phe Val Pro Lys Val He Glu Val He Arg His Pro Lys Asp Lys

1605 1610 1615

Ala Glu Ser Lys Tyr Asn Pro Asp Ser Ala He Ser Lys Glu Asp Glu

1620 1625 1630

Glu Arg Tyr Gin Lys Leu Val Thr Glu Asn Glu Glu Leu Gin Arg Leu

1635 1640 1645

He Thr Gin Lys Glu Glu Lys He Arg Val Leu Arg Gin Arg Leu Val

1650 1655 1660

Glu Arg Gly Asp Ala Lys Gly Thr Glu Leu Asn Gly Ala Thr Gly Val 1665 1670 1675 1680

Ala Ser Ala Ala Val Ala Thr Thr Ser Gin Pro Ala Ser Leu He Asn

1685 1690 1695

Ser Ser Ala His Ala Thr Pro Ala Ala Thr Leu Ala He Thr Gin Gly

1700 1705 1710

Glu

<210> 178

<211> 4463

<212> DNA

<213> Drosophila

<400> 178 tgtgggtggt tcgcacgccc gccatttccg gcgcggcctc ggataacgtc ctcgattacg 60 ccctgccgcc caacacgccc actccgaagg actacgcgca caagttcctg cccgagggca 120 aggatgtggt acccggaagc tcttacatac cgctgcggtt gctggtgata aagcgctgaa 180 gctgatatat gaatcttggg cggcggcttg ccttttgttg ttcgaaaaca agttccggcg 240 gaatgccgat acccgacact taatgcccaa ccagtagttg gctaattggc tttaagctta 300 ctggttccta gcgctagtct agcaatagtt tagttgttta tgttaaggcc caagttcgct 360 aatctaaatt aagccaccac atcccggggt ccgtgactaa gacttccgac cttatcgcat 420 ccaataaatc caaaactaag actcagccac atgccgtcgt aatctatgaa atacattcac 480 caaaaactaa gttgtcatct catttacata aattagaagt cataaatttg aagtgagcgg 540 ggaactactt ggctcgaaac ggttagaagc tgaattcaaa accggttaac gtttatctgt 600 cagctgtaat caaaagctta aagcttcgct tgtttggttt agtctttgac taagtttgga 660 aagcaggact aaaagctttt atttgccgaa actaaagctc ggaggtattt atttattcac 720 aagtaaaatg acaaaacttg gaagttcttt ggtaatgtaa tgaacgccaa tatttacatt 780 cgggttttat tgtatttgaa aagtctgatg aatcattatc ttgatgactg gcccctaatt 840 tacttttcat gttctacgca aggggtatga taactggttg acatggatac caagattaga 900 gcttgcagac tttataatca tccaacaaac attatggtgc attgtatacc atttatgtta 960 tgaatgaaag tggttcagat aagttacatt ttattttatc tcacacatct aagtttttgt 1020 attgctgcac aggaaaataa atcaagatta tccacaatag tttaaaagtc aatttatagg 1080 tactatgtag aatttattta cattttgttg tactaatggt aacttaactt aggtttttaa 1140 atactagtac tgtttgttga tgaatggctt aggccttgca aaatcgagtc agtgggcatt 1200 tgtatagttt gctgatttct cttcttgctc gaattgcaac agagacccaa ccaggcccgc 1260 tggttctctt tgttaaatac tataaagtaa aggaataaaa caaatccctg taaagtggct 1320 gtcaggcaga ataaataggc gaagatcctt ccgaaatcga agtatgtaca caatccaaaa 1380

231 atccatgtta ttcccaaaag aaagaagagc aacacaaaca ggccgagttg cttgaagata 1440 aggtcacgtt tgaacagggc tgtatagaca ctccaggaga tgtatcccac caatattgca 1500 ttggccaccg tgataaggcc aatagggagt atgacgccca gacttaaacc atatccagaa 1560 ggatagcaga ggatgggata gtccattgag gaattattgg gtctgtagga accgggctcc 1620 agaaaaacca ccaacaaggt gggtataagt ggcaatgtcc aggccgccac agccgacatt 1680 agtatataat gtcgtgggtg attaactcca atgactctca catatctttg atactgcaga 1740 aatccaatga taaacatcca gctgaagaca accaagagta gatattgcat cacggctcca 1800 accagagtac atcgttccga ctcagattgt tccagctgct ccagcaaatg gctttgactc 1860 aggatcagga agaagagcaa ctgaagaccc agggcagcac acagattcag caatatcttc 1920 gtggaggcta atgtccggaa gctcttaaac acggctgcag ttataaaaat cattaggagg 1980 cccaacagag aaagggtcaa gccgacattg gtgattacat ctaaggagtg atcatcttca 2040 ttggtgtcca gacctgcctg cattttgctc actcccagta gaaatgtaaa ctgggtcaga 2100 tgatccgcat ggcagaggat cactgggtgc gatgaggctt ccaagctgcc accaccgctg 2160 gtggatattc catcgctaag ccaggtctca tagttccagt aaccacatcc tccctcaaat 2220 tgagtttcat tcgcttttgc attacgcaag aaaaatggca actttccagg tagcttggta 2280 tcttacgaaa agattttaga ttaaaacata tatgctataa ttttccctca acccactcac 2340 cattcaatcc tggtattgtt atggatataa cattactagt tggccgtcgt ttgatttcct 2400 cttccgtctc cacaaagagt gaatctcgag tatagacctt aaaaactaag taagaggctc 2460 cctttctctt cagttgggtc catagttttt cgggaataaa gaccgcactt tctagattct 2520 tcatggccct tatatcttcc tcattatccg ataggtgaag catttcgaaa tgcgacatat 2580 tgccaccaga gaagttcact atcccactca catttctcac ttctggatct acaaagaata 2640 ctctgagttc gctcgtcttt agaacaatga cacccatatc aaacaaggga tggaatgtga 2700 actcagtgct gtttgcaaaa atagtggtgt ttaactttaa aattgttgga ctaagctcat 2760 ccaaataatc ctcgaagttg ctaaggagtg cattggttgc attagcgtct gctgaaacac 2820 gaagggtttc attatctgta gacataactt tttggcatat cttcatcaag tcccctacaa 2880 ctgcagcatt tctttccggt tttttgacca gcgaatcgaa tatctccgaa atactgaaga 2940 catcggcggc ggccagtttc tcctgagttt gagtcaggag gttactcagt tggctaatca 3000 tgtccggagg gctcttcaca gcgagaaggt ttatactcga gctgagttcc ggtgccgacc 3060 tacaggtcac gtgatccaag ctctgccaaa ctctattccc attgcgaatt tggcacctcc 3120 gtcggatggg aattccccgt tcgttcaggc atagatccct tagattcgcc ttttgcccaa 3180 ctctcgtttt ctccacgcga ttgattcgct tttccttgcc ttcatccgtt tcgtattcca 3240 gttcaaagtc ctcggccttg cagaatcctc ggttgcagtc cttgtaggga ttgtgcgaca 3300 gctgaccatc tgcatccacg cagaggagga agcgcaagtt cttcaggtgg cagtagtcca 3360 gacaccgggc cacattcggc tgatccaggg cgtacagggg gggatttgta cctccagata 3420 cgagtattat atagccagca atccaccaga gaaacagcag catactgcta tctattttta 3480 actaatttaa gcgcaggctg cgatgtcgca ctcccgaagc tccgcgatcg actgacgagg 3540 cggagataaa atgcgagtgg cgataaaacg agttttcctc tcctcatccc tgtaaatagg 3600 gcctgcaaga attgccactt tcctcactgt tctagctggg tatttgaatt gctggtctac 3660 ttcgagcaga gctcaaggtc aactggttat ctggccgacg ataagaattg cagcatcttc 3720 aaaggtcgaa cggtgcgttc ttttcaaaat atctttgaat ataataagtg aaagtctcga 3780 aaataacacg aacctcttta ataatgggta ttatttatac acagtagttc tgtttacttt 3840 gatcacattt tttatcaagg gaacttccta attaaaaaca aaaaaaaaaa aacgaatagc 3900 ctgataaaga gctaaatggt aattatcaaa attatatata ccatacaccc aacgataatg 3960 ataatttgtt tatcgcagta aagtgagatt ctctgaattg ataaaggtta attgccgttt 4020 ttcaacacca ttgcatgtat cgataaaact aataggaatt acaaataaat taaaaatctg 4080 aattttcttt tttgctctgg gtaacaatgg ctgccatttc tgaatgtttc tgttattctc 4140 tctgatttta aaagtgcaac gatacttaac acgaactttg agttgctagt cgccataagc 4200 atatgaatgc atcaatcggt agctaggggc tgtcaacaac tacaatatgt atgataagca 4260 gccaccttta gatactttcc ttactaacac ctagaaggta gagatagagg tattcaaata 4320 tttgcattca gatataaaat aatgttctct tgttcaagct gtgaaatctt tatctgtaga 4380 gataaagtga gcatttcaat tgaagaacca atttgtatat ttttttagat ttcaccgaac 4440 gcatgaatag aatttgtctg eta 4463

<210> 179

<211> 1938

<212> DNA

<213> Drosophila

<400> 179 atgctgctgt ttctctggtg gattgctggc tatataatac tcgtatctgg aggtacaaat 60

232 ccccccctgt acgccctgga tcagccgaat gtggcccggt gtctggacta ctgccacctg 120 aagaacttgc gcttcctcct ctgcgtggat gcagatggtc agctgtcgca caatccctac 180 aaggactgca accgaggatt ctgcaaggcc gaggactttg aactggaata cgaaacggat 240 gaaggcaagg aaaagcgaat caatcgcgtg gagaaaacga gagttgggca aaaggcgaat 300 ctaagggatc tatgcctgaa cgaacgggga attcccatcc gacggaggtg ccaaattcgc 360 aatgggaata gagtttggca gagcttggat cacgtgacct gtaggtcggc accggaactc 420 agctcgagta taaaccttct cgctgtgaag agccctccgg acatgattag ccaactgagt 480 aacctcctga ctcaaactca ggagaaactg gccgccgccg atgtcttcag tatttcggag 540 atattcgatt cgctggtcaa aaaaccggaa agaaatgctg cagttgtagg ggacttgatg 600 aagatatgcc aaaaagttat gtctacagat aatgaaaccc ttcgtgtttc agcagacgct 660 aatgcaacca atgcactcct tagcaacttc gaggattatt tggatgagct tagtccaaca 720 attttaaagt taaacaccac tatttttgca aacagcactg agttcacatt ccatcccttg 780 tttgatatgg gtgtcattgt tctaaagacg agcgaactca gagtattctt tgtagatcca 840 gaagtgagaa atgtgagtgg gatagtgaac ttctctggtg gcaatatgtc gcatttcgaa 900 atgcttcacc tatcggataa tgaggaagat ataagggcca tgaagaatct agaaagtgcg 960 gtctttattc ccgaaaaact atggacccaa ctgaagagaa agggagcctc ttacttagtt 1020 tttaaggtct atactcgaga ttcactcttt gtggagacgg aagaggaaat caaacgacgg 1080 ccaactagta atgttatatc cataacaata ccaggattga atgataccaa gctacctgga 1140 aagttgccat ttttcttgcg taatgcaaaa gcgaatgaaa ctcaatttga gggaggatgt 1200 ggttactgga actatgagac ctggcttagc gatggaatat ccaccagcgg tggtggcagc 1260 ttggaagcct catcgcaccc agtgatcctc tgccatgcgg atcatctgac ccagtttaca 1320 tttctactgg gagtgagcaa aatgcaggca ggtctggaca ccaatgaaga tgatcactcc 1380 ttagatgtaa tcaccaatgt cggcttgacc ctttctctgt tgggcctcct aatgattttt 1440 ataactgcag ccgtgtttaa gagcttccgg acattagcct ccacgaagat attgctgaat 1500 ctgtgtgctg ccctgggtct tcagttgctc ttcttcctga tcctgagtca aagccatttg 1560 ctggagcagc tggaacaatc tgagtcggaa cgatgtactc tggttggagc cgtgatgcaa 1620 tatctactct tggttgtctt cagctggatg tttatcattg gatttctgca gtatcaaaga 1680 tatgtgagag tcattggagt taatcaccca cgacattata tactaatgtc ggctgtggcg 1740 gcctggacat tgccacttat acccaccttg ttggtggttt ttctggagcc cggttcctac 1800 agacccaata attcctcaat ggactatccc atcctctgct atccttctgg atatggttta 1860 agtctgggcg tcatactccc tattggcctt atcacggtgg ccaatgcaat attgcaatac 1920 aaaaacttag atgtgtga 1938

<210> 180 <211> 645 <212> PRT <213> Drosophila

<400> 180

Met Leu Leu Phe Leu Trp Trp He Ala Gly Tyr He He Leu Val Ser

1 5 10 15

Gly Gly Thr Asn Pro Pro Leu Tyr Ala Leu Asp Gin Pro Asn Val Ala

20 25 30

Arg Cys Leu Asp Tyr Cys His Leu Lys Asn Leu Arg Phe Leu Leu Cys

35 40 45

Val Asp Ala Asp Gly Gin Leu Ser His Asn Pro Tyr Lys Asp Cys Asn

50 55 60

Arg Gly Phe Cys Lys Ala Glu Asp Phe Glu Leu Glu Tyr Glu Thr Asp 65 70 75 80

Glu Gly Lys Glu Lys Arg He Asn Arg Val Glu Lys Thr Arg Val Gly

85 90 95

Gin Lys Ala Asn Leu Arg Asp Leu Cys Leu Asn Glu Arg Gly He Pro

100 105 110

He Arg Arg Arg Cys Gin He Arg Asn Gly Asn Arg Val Trp Gin Ser

115 120 125

Leu Asp His Val Thr Cys Arg Ser Ala Pro Glu Leu Ser Ser Ser He

130 135 140

Asn Leu Leu Ala Val Lys Ser Pro Pro Asp Met He Ser Gin Leu Ser 145 150 155 160

Asn Leu Leu Thr Gin Thr Gin Glu Lys Leu Ala Ala Ala Asp Val Phe

233 165 170 175

Ser He Ser Glu He Phe Asp Ser Leu Val Lys Lys Pro Glu Arg Asn

180 185 190

Ala Ala Val Val Gly Asp Leu Met Lys He Cys Gin Lys Val Met Ser

195 200 205

Thr Asp Asn Glu Thr Leu Arg Val Ser Ala Asp Ala Asn Ala Thr Asn

210 215 220

Ala Leu Leu Ser Asn Phe Glu Asp Tyr Leu Asp Glu Leu Ser Pro Thr 225 230 235 240

He Leu Lys Leu Asn Thr Thr He Phe Ala Asn Ser Thr Glu Phe Thr

245 250 255

Phe His Pro Leu Phe Asp Met Gly Val He Val Leu Lys Thr Ser Glu

260 265 270

Leu Arg Val Phe Phe Val Asp Pro Glu Val Arg Asn Val Ser Gly He

275 280 285

Val Asn Phe Ser Gly Gly Asn Met Ser His Phe Glu Met Leu His Leu

290 295 300

Ser Asp Asn Glu Glu Asp He Arg Ala Met Lys Asn Leu Glu Ser Ala 305 310 315 320

Val Phe He Pro Glu Lys Leu Trp Thr Gin Leu Lys Arg Lys Gly Ala

325 330 335

Ser Tyr Leu Val Phe Lys Val Tyr Thr Arg Asp Ser Leu Phe Val Glu

340 345 350

Thr Glu Glu Glu He Lys Arg Arg Pro Thr Ser Asn Val He Ser He

355 360 365

Thr He Pro Gly Leu Asn Asp Thr Lys Leu Pro Gly Lys Leu Pro Phe

370 375 380

Phe Leu Arg Asn Ala Lys Ala Asn Glu Thr Gin Phe Glu Gly Gly Cys 385 390 395 400

Gly Tyr Trp Asn Tyr Glu Thr Trp Leu Ser Asp Gly He Ser Thr Ser

405 410 415

Gly Gly Gly Ser Leu Glu Ala Ser Ser His Pro Val He Leu Cys His

420 425 430

Ala Asp His Leu Thr Gin Phe Thr Phe Leu Leu Gly Val Ser Lys Met

435 440 445

Gin Ala Gly Leu Asp Thr Asn Glu Asp Asp His Ser Leu Asp Val He

450 455 460

Thr Asn Val Gly Leu Thr Leu Ser Leu Leu Gly Leu Leu Met He Phe 465 470 475 480

He Thr Ala Ala Val Phe Lys Ser Phe Arg Thr Leu Ala Ser Thr Lys

485 490 495

He Leu Leu Asn Leu Cys Ala Ala Leu Gly Leu Gin Leu Leu Phe Phe

500 505 510

Leu He Leu Ser Gin Ser His Leu Leu Glu Gin Leu Glu Gin Ser Glu

515 520 525

Ser Glu Arg Cys Thr Leu Val Gly Ala Val Met Gin Tyr Leu Leu Leu

530 535 540

Val Val Phe Ser Trp Met Phe He He Gly Phe Leu Gin Tyr Gin Arg 545 550 555 560

Tyr Val Arg Val He Gly Val Asn His Pro Arg His Tyr He Leu Met

565 570 575

Ser Ala Val Ala Ala Trp Thr Leu Pro Leu He Pro Thr Leu Leu Val

580 585 590

Val Phe Leu Glu Pro Gly Ser Tyr Arg Pro Asn Asn Ser Ser Met Asp

595 600 605

Tyr Pro He Leu Cys Tyr Pro Ser Gly Tyr Gly Leu Ser Leu Gly Val

610 615 620

He Leu Pro He Gly Leu He Thr Val Ala Asn Ala He Leu Gin Tyr 625 630 635 640

Lys Asn Leu Asp Val

234 645

<210> 181 <211> 6938 <212> DNA <213> Drosophila

<400> 181 cagctagtag tgaataatac ttgagttttt gagtttgttg ggctgggttg aaaaaaaaaa 60 atatgcactt tagcctctat taagcatttt cctatggttt tcactctcgt tcgggaactg 120 tgtgttttga aaatgtaaca atttgcgctt tcgtcctcgt acattgtgtg tatttacaga 180 aagtctagcc catttttaga ttttgtatgg gaatgagtgg aaattacaag tgtataatat 240 ataatacaaa tacactttag ttggtaagat tagcaagacg taagacgtac gatagttaat 300 gaggggggaa ttgctagttt tatgttaatg cctataagct caaatttaca actgattatt 360 cgctgatcga aaatgatctc aagatctcta tcatttgttt agctttagtg tggatagtgt 420 tgaaaggttg acttgaaagc aaatggttag taactaactg tcgaggaact tagaggtaaa 480 cgaaaacgcg tgttttagga atgggtttgt ttttcttagt gtatgtggcc ttgtttttac 540 agttatatcg ttacctacac aggtgggctc tgttttaccg atctaaacgt ttgaacaact 600 ttgatctatc agtgatccta atcaatcgaa atcaatcgaa ctcaagactg acagaaatca 660 acgtaaacta aagtaaaatc gtctaaaaat ttatcaaaac tttataaaac ttcttggctg 720 ctttcaaggt tcctcacttt acgtttcatt gaaaaataaa gtaatatttg ttattgtttg 780 tgtttggtga gtgtttgttg catctccatt tgcatcaatc attttcctgc tggttttttt 840 tttctttctt tgcgaaatta aagtaattct tttattgttt gtgttgttgc gctatataat 900 aactatttct cacatattat ctacacatac caacgtgtat cgtaccgttt aatacctata 960 tacaattctc aaatatccgc catgaaccag caaggactcc ctacttcgaa tgcgagacca 1020 cggagtggga gaccatcgag tgagagagca ttgagtggga cacgccggag atttccgcat 1080 aggtatccgt gggtccttcg gcactgcaca ccgaatcctc gggcgtcctg gaaggttccg 1140 cctcggtgat ctcgatgtcc tgatgatgct tgttgctgcg gtgtttggca cttagagcct 1200 gcgaatttga gatattttag tgggtcacat ggacaactgg tggatatgtg ttttctcgtt 1260 gtagtttcgt gtgcaatctg ttttcgataa gacttatgtg gtgctatcta tgggacggac 1320 acatgcacac acacacacac acacgcacaa gctggtggtt tcgggttcat tggggaactt 1380 tgggtctaag tttatagaca aacgtgcgag aaattctttt gatttagtcg ttttgttttg 1440 gattttagtt tacattcaca acacagatat tttagcaggt taggtttaga ggtttatgct 1500 aaaagcaacc gaaaattctt accttatcct tgctgccctt tttctacatt gaacattggt 1560 ggttattgtt ttgtttggtt tggttgtggt gggtttcgaa tatattgtac atagtcatga 1620 caagaacaat gatatttata gatgtattaa tataagtggc aaacagtact gcgagttcac 1680 attggaggat caagagaagt acagattcat agacggttag agagacgggg gagagagaaa 1740 gatctaggga gcgtggggat gggcagcaaa aggtttggtt tcggattgaa gaataacagc 1800 aatatcgatc tgaggcctac agcccggttc cccattctgg ccacgtcaat gtcatgtaca 1860 gtgagcacta tggctggtgg tggactacgc tgccgttgtg gtgaccccga ctcacctgca 1920 gggagaagcg acggtgaccc gccttgcgtc cgccacgtcg cttactgatg tgcggattgt 1980 cctgccgcag agtcttgttc ttcattatct ccaattgggt atacagtctg gaatcgaaaa 2040 tgtatagaaa atagagataa tagaacatat agatatgctt cgtacctttt gagttcggcg 2100 cgtatgtcct cgggactcat ttcggatatg gtcagctcac caatgtccgg atcgcccaga 2160 cagagcccgg catatcctcc gcccagccgc tggccggcgt cgtgtgacgt acccttgaaa 2220 gcatccacag gtaaacgtat tgatagatca tacgctagcg aacgaacctg caagctatga 2280 agatgcaaca aacaccgcaa accacactca ggaagtcaaa cggaaaatgg agaacggaac 2340 ggaaacggaa atggaaacgg aactcaaagg taagagagag caaaatcgca tggtatagat 2400 ctgtgctgaa gagttatgta tagttatatg tatatagtat gtgtatgggt ggtctgtgct 2460 tattggtcgt gattgtatct ttgggggtgc tggaaatgaa cgaaaagaaa caaatcaaat 2520 taaaaaagta actcaaaagg taaacaagat ggacgatagc tataagaaga ctacttagac 2580 agagaacttc agtttaagat tattcagttg aggcacagaa agacagagaa agttacagtg 2640 aggcagagtc ttggatacac tagtttggaa tttttttttc tggtatgcat attggaaatt 2700 ttgaaaggaa accgattttt gtcatttgtt tgttagtagt tagatgttgt gttttcttgt 2760 taaattcatg caaaaatcaa cactaaacat gcaaattaaa tggcgtgctt attgagttca 2820 agttaaagtg caatacattc aggcataaat aataagagct aaaaacagtc gaacattctc 2880 tgtttaaacg agacacactt gcagcaactt catagcttga ctaaagtttc aattcaatgt 2940 tagcttatta ctaaaattat gttaattttc tcggtgaaaa ccagaacaag aactcaaaat 3000 ataaccataa acaaatgaaa tattcaaatt gtattttaat tagcaaaagc aaccaagctt 3060

235 ttgagtggat gtccacattt taatacttct tgtgttttgg ctagttattt aacaaaaatc 3120 gtttcctcaa ccaatgtcaa taccaagtac gcatttcgat gactataatg acgaccacgc 3180 ccacgacaga cgaaaggcac aaaatgaacg ggtgtgaata ctctaagcat atgaattata 3240 ttcgtttggt gcccgactag gacaaaacac ttcctaatta catcatatat ctcaatgtgt 3300 agaacacaaa agcgtactca aaccaaaaaa aaaaaaaaaa aaaccaaagc aaagtaagta 3360 aatcatatcg tttcgaactc aaatcggtta cctgcttgtg ctggtaccac aactttggca 3420 caaatatcag acccaaggcg aaactattcg tcagctggga gcggatgaac agggccagca 3480 agatggcgct gggactcatt tccggcaggt agacaaagcg cagaaagtag aagctggacg 3540 agaccaggaa ctccagcgtc agtgcggtga ccagaaattg tcgttccttc aatgggacaa 3600 aaggaaatta ccgattaatt catttgactt gacttaaatt ccccttctac ttagttaatc 3660 atctaagcca atctcttgcg cttaattgat aaagaaagat ctgcaatcga tttgactgta 3720 catcttaccc ggaactgggt gttggcattc cgactggcga tggacaggtg cagtccaaag 3780 cacaggatga gcatctcgct ggtctgcgtg accagttccc acttgagcgg atggcaggtg 3840 ttcgtgtccg cctccctgag gctctccagc tgcgcacttt cgagaagatc caacgacgag 3900 gccgtaaagg cggccatgta gcagatgacg gcaaagacca tggtgcccag atacttgagc 3960 aggtccacgt cgcgcagcac ccagcgatgc gctttccggg tgcgaaagtc caccaggtgg 4020 cggtacaact tcagtatgat ggcgccgtag caggtgatga agcccagctc ccgaagccag 4080 ggctccagaa ggcagcgctc ggtggatgcg ggaaagaaat ggacggcaac ctaaagatga 4140 atatgtaaat acacacagaa gttgaaggtg accatcgcca ggagcactca cagatgcata 4200 aagtaaaaca atgcccagca gtatcgtctc cagcacagtc cacataccag acgcaatggc 4260 ctgaaaatga tgaaaggatt actcaaagtt tcccaacttt aggatatgta aactaaatac 4320 cttgcacttt cgctgccgga agacaatcac cccgaggaca atgcagcaca ggatgcaggc 4380 gcccagtacg atggccacca ggaggcgcag acaggcgtcc acattgagca cctcctcctc 4440 ctgaaaggtc agacagacgc cgttgctatc gcagttagtg catccgccgg gacacggaat 4500 gcacgagtag ttgtcgtagc cctcggacag ttccactcga tcgccacgga atccctggag 4560 cgtggaattg ggcaggtagt aggattcccg gcacagacag gtgtacacat cccgggtggc 4620 ggcgggtttg ttctcggtga gcaggcagaa ggtcgtattc cgatcgcaac tacagagata 4680 tggtattata tatattatcc agaactaatg tcacgaatta tcgtataaag tttggccaca 4740 actcacccat gacggcgacc gaaaacttcc tccaggccat cgttgcacac atcctcgtcg 4800 gcggcaatga aggcagccgc cacaactctg aaagcattta gcataaatta caaagttgtg 4860 ccaaccagct gcacatcgat gcgactcact tgatcctgtg ctcgctgaag gatatgcgaa 4920 atggccagag ccagcgacgc gtcaacaggt tgcagtcgcg aaatggagcg ccccactcct 4980 gggtgccgtc cgtgctgttc caggccgcac tgtagtcggg taaaataata catttatggg 5040 caactttcca agattatacg gcttatggtc tattcaaatt aagcgatgca cattatttcg 5100 gcaagctacg gtgcatattg aatttaattg tatttatctt ttagagtaat tagtatttgc 5160 atttcaaagc cataagataa ttgattttaa tttgttgcta attaatgtcg cacacttttt 5220 tgggacacaa ccagtcttcg aaacttaccc caactcccgc caataggaac ccaaatatgc 5280 cttattgtgc acctgatccg gtggtatctg caataagtta aatcgattag cccatggccc 5340 cattatcgct gattagcgag tgcataccgt aacgttatcc ctgaatttaa cgaccaccgt 5400 gtgaatgctg ggcgcggcaa tggcgaatgc cagcagattg tcgtcctcgt tgagggcgta 5460 gctggcgatt ccattggccc ggcgactcac ctccgcacgt gtcggctcat cgatggcaat 5520 cggtgtgttg gcatttggga atttgcccga taaaaattca ataaactggc gtgcggcatc 5580 ctcggcgatg tcggtgtagt cgtaaaactg ttgaattcat aaaaccagat cacaattaat 5640 tgcgttgtgt cataaataat catttcaatg tatatgaaat gggcatataa atatcattta 5700 aatcgaattc gatttaaata cacaaagaaa aagttcaata aaattaacac agcataaatt 5760 tacgctttgc taaactcaat ttatttatac cacactatat aggaaacgga aaacgtgtgc 5820 tttctaattg aagatatttt cggaaattgc gaaaaaatta cgtatatgcc acgtatattg 5880 gtcgccacgt gatttaagtg accatgcggc acggccactt cccccgactt gggaccatta 5940 attattcacc tggcgcacag gacacgtttc acagcaacac cttgcggcaa gagtgcgaaa 6000 agttttgctt cgtttcgact gtgaaataat aggatttaat accctcgccg tgctgtggga 6060 ctgcgggaag ggtttttaat ccaagttcgt tcagctccta accgaccaaa tgtttataca 6120 taatttacac gttacaagaa actctcgaga tctacgcacc aaagtgtagg aaatggtagg 6180 gccactttga tgacatcatt atggctttgg gaaacaaaag taaccacaga agggagcagg 6240 gagggggttg ctggtagcgg ggaaaaagga cacgttgttt gggcgtgagt catgtagttg 6300 ggctggcggc accttttggc ttttaaaaca aatatttccc attagctggg ctttcggtga 6360 tgagcgacca cattgcgtat acgccaccga agccaccaaa taaattgcca acaagtaaca 6420 tcgatataca aacgtttgct ggatgctcct ctaccatgtg tgtgtgagtg tgtttcttca 6480 ttttttttcc tgccaaacgt gagccaaaat ttacacatcg aggcaaaagc aatcagtata 6540 aggcagctgg agaaatggca cgagacctgc tcccagataa agtcattatg tagtgctcct 6600 agcactcgcg cgcagccata atcataaaca tttggtatac tcttgcatgc tagagaaata 6660

236 ttgtagttgg gtaagtgttt tcagatatta aactaagtaa ggaaatattt ctatttttac 6720 accattattc attgtttttt cttcaggagt tatctgaact ttaagtaatc ccaccacagt 6780 tcttggaagc agtagaatgt cttcattacc gccaaatcct tttgatatcc tttttcccaa 6840 atgtccgcaa ttacacacat accctcgcac tagcgcccct cgttttttca gggtataaat 6900 gtatggggaa aacacttgta aatagcggca gcagccac 6938

<210> 182 <211> 2010 <212> DNA <213> Drosophila

<400> 182 atggtcccaa gtcgggggaa gtggccgtgc cgcatgtttt acgactacac cgacatcgcc 60 gaggatgccg cacgccagtt tattgaattt ttatcgggca aattcccaaa tgccaacaca 120 ccgattgcca tcgatgagcc gacacgtgcg gaggtgagtc gccgggccaa tggaatcgcc 180 agctacgccc tcaacgagga cgacaatctg ctggcattcg ccattgccgc gcccagcatt 240 cacacggtgg tcgttaaatt cagggataac gttacgatac caccggatca ggtgcacaat 300 aaggcatatt tgggttccta ttggcgggag ttgggtgcgg cctggaacag cacggacggc 360 acccaggagt ggggcgctcc atttcgcgac tgcaacctgt tgacgcgtcg ctggctctgg 420 ccatttcgca tatccttcag cgagcacagg atcaaagttg tggcggctgc cttcattgcc 480 gccgacgagg atgtgtgcaa cgatggcctg gaggaagttt tcggtcgccg tcatggttgc 540 gatcggaata cgaccttctg cctgctcacc gagaacaaac ccgccgccac ccgggatgtg 600 tacacctgtc tgtgccggga atcctactac ctgcccaatt ccacgctcca gggattccgt 660 ggcgatcgag tggaactgtc cgagggctac gacaactact cgtgcattcc gtgtcccggc 720 ggatgcacta actgcgatag caacggcgtc tgtctgacct ttcaggagga ggaggtgctc 780 aatgtggacg cctgtctgcg cctcctggtg gccatcgtac tgggcgcctg catcctgtgc 840 tgcattgtcc tcggggtgat tgtcttccgg cagcgaaagt gcaaggccat tgcgtctggt 900 atgtggactg tgctggagac gatactgctg ggcattgttt tactttatgc atctgttgcc 960 gtccatttct ttcccgcatc caccgagcgc tgccttctgg agccctggct tcgggagctg 1020 ggcttcatca cctgctacgg cgccatcata ctgaagttgt accgccacct ggtggacttt 1080 cgcacccgga aagcgcatcg ctgggtgctg cgcgacgtgg acctgctcaa gtatctgggc 1140 accatggtct ttgccgtcat ctgctacatg gccgccttta cggcctcgtc gttggatctt 1200 ctcgaaagtg cgcagctgga gagcctcagg gaggcggaca cgaacacctg ccatccgctc 1260 aagtgggaac tggtcacgca gaccagcgag atgctcatcc tgtgctttgg actgcacctg 1320 tccatcgcca gtcggaatgc caacacccag ttccgggaac gacaatttct ggtcaccgca 1380 ctgacgctgg agttcctggt ctcgtccagc ttctactttc tgcgctttgt ctacctgccg 1440 gaaatgagtc ccagcgccat cttgctggcc ctgttcatcc gctcccagct gacgaatagt 1500 ttcgccttgg gtctgatatt tgtgccaaag ttgtggtacc agcacaagca gggtacgtca 1560 cacgacgccg gccagcggct gggcggagga tatgccgggc tctgtctggg cgatccggac 1620 attggtgagc tgaccatatc cgaaatgagt cccgaggaca tacgcgccga actcaaaaga 1680 ctgtataccc aattggagat aatgaagaac aagactctgc ggcaggacaa tccgcacatc 1740 agtaagcgac gtggcggacg caaggcgggt caccgtcgct tctccctgca gaaaaagggc 1800 agcaaggata aggctctaag tgccaaacac cgcagcaaca agcatcatca ggacatcgag 1860 atcaccgagg cggaaccttc caggacgccc gaggattcgg tgtgcagtgc cgaaggaccc 1920 acggatacct atgcggaaat ctccggcgtg tcccactcaa tgctctctca ctcgatggtc 1980 tcccactccg tggtctcgca ttcgaagtag 2010

<210> 183 <211> 669 <212> PRT <213> Drosophila

<400> 183

Met Val Pro Ser Arg Gly Lys Trp Pro Cys Arg Met Phe Tyr Asp Tyr

1 5 10 15

Thr Asp He Ala Glu Asp Ala Ala Arg Gin Phe He Glu Phe Leu Ser

20 25 30

Gly Lys Phe Pro Asn Ala Asn Thr Pro He Ala He Asp Glu Pro Thr

237 35 40 45

Arg Ala Glu Val Ser Arg Arg Ala Asn Gly He Ala Ser Tyr Ala Leu

50 55 60

Asn Glu Asp Asp Asn Leu Leu Ala Phe Ala He Ala Ala Pro Ser He 65 70 75 80

His Thr Val Val Val Lys Phe Arg Asp Asn Val Thr He Pro Pro Asp

85 90 95

Gin Val His Asn Lys Ala Tyr Leu Gly Ser Tyr Trp Arg Glu Leu Gly

100 105 110

Ala Ala Trp Asn Ser Thr Asp Gly Thr Gin Glu Trp Gly Ala Pro Phe

115 120 125

Arg Asp Cys Asn Leu Leu Thr Arg Arg Trp Leu Trp Pro Phe Arg He

130 135 140

Ser Phe Ser Glu His Arg He Lys Val Val Ala Ala Ala Phe He Ala 145 150 155 160

Ala Asp Glu Asp Val Cys Asn Asp Gly Leu Glu Glu Val Phe Gly Arg

165 170 175

Arg His Gly Cys Asp Arg Asn Thr Thr Phe Cys Leu Leu Thr Glu Asn

180 185 190

Lys Pro Ala Ala Thr Arg Asp Val Tyr Thr Cys Leu Cys Arg Glu Ser

195 200 205

Tyr Tyr Leu Pro Asn Ser Thr Leu Gin Gly Phe Arg Gly Asp Arg Val

210 215 220

Glu Leu Ser Glu Gly Tyr Asp Asn Tyr Ser Cys He Pro Cys Pro Gly 225 230 235 240

Gly Cys Thr Asn Cys Asp Ser Asn Gly Val Cys Leu Thr Phe Gin Glu

245 250 255

Glu Glu Val Leu Asn Val Asp Ala Cys Leu Arg Leu Leu Val Ala He

260 265 270

Val Leu Gly Ala Cys He Leu Cys Cys He Val Leu Gly Val He Val

275 280 285

Phe Arg Gin Arg Lys Cys Lys Ala He Ala Ser Gly Met Trp Thr Val

290 295 300

Leu Glu Thr He Leu Leu Gly He Val Leu Leu Tyr Ala Ser Val Ala 305 310 315 320

Val His Phe Phe Pro Ala Ser Thr Glu Arg Cys Leu Leu Glu Pro Trp

325 330 335

Leu Arg Glu Leu Gly Phe He Thr Cys Tyr Gly Ala He He Leu Lys

340 345 350

Leu Tyr Arg His Leu Val Asp Phe Arg Thr Arg Lys Ala His Arg Trp

355 360 365

Val Leu Arg Asp Val Asp Leu Leu Lys Tyr Leu Gly Thr Met Val Phe

370 375 380

Ala Val He Cys Tyr Met Ala Ala Phe Thr Ala Ser Ser Leu Asp Leu 385 390 395 400

Leu Glu Ser Ala Gin Leu Glu Ser Leu Arg Glu Ala Asp Thr Asn Thr

405 410 415

Cys His Pro Leu Lys Trp Glu Leu Val Thr Gin Thr Ser Glu Met Leu

420 425 430

He Leu Cys Phe Gly Leu His Leu Ser He Ala Ser Arg Asn Ala Asn

435 440 445

Thr Gin Phe Arg Glu Arg Gin Phe Leu Val Thr Ala Leu Thr Leu Glu

450 455 460

Phe Leu Val Ser Ser Ser Phe Tyr Phe Leu Arg Phe Val Tyr Leu Pro 465 470 475 480

Glu Met Ser Pro Ser Ala He Leu Leu Ala Leu Phe He Arg Ser Gin

485 490 495

Leu Thr Asn Ser Phe Ala Leu Gly Leu He Phe Val Pro Lys Leu Trp

500 505 510

Tyr Gin His Lys Gin Gly Thr Ser His Asp Ala Gly Gin Arg Leu Gly

238 515 520 525

Gly Gly Tyr Ala Gly Leu Cys Leu Gly Asp Pro Asp He Gly Glu Leu 530 535 540

Thr He Ser Glu Met Ser Pro Glu Asp He Arg Ala Glu Leu Lys Arg

545 550 555 560

Leu Tyr Thr Gin Leu Glu He Met Lys Asn Lys Thr Leu Arg Gin Asp 565 570 575

Asn Pro His He Ser Lys Arg Arg Gly Gly Arg Lys Ala Gly His Arg 580 585 590

Arg Phe Ser Leu Gin Lys Lys Gly Ser Lys Asp Lys Ala Leu Ser Ala 595 600 605

Lys His Arg Ser Asn Lys His His Gin Asp He Glu He Thr Glu Ala 610 615 620

Glu Pro Ser Arg Thr Pro Glu Asp Ser Val Cys Ser Ala Glu Gly Pro

625 630 635 640

Thr Asp Thr Tyr Ala Glu He Ser Gly Val Ser His Ser Met Leu Ser 645 650 655

His Ser Met Val Ser His Ser Val Val Ser His Ser Lys 660 665

<210> 184 <211> 4243 <212> DNA <213> Drosophila

<400> 184 ctcgtgacct ttgaacccga cgctggcact ttgaaacgga aacggaaaca cacactcaca 60 cacacgtaat ttggttagtc tgatatcgat gcactatatg ttggctaatt tagacggact 120 ttggttttga ccaatcgcca gggtcctaca tatatggttt tgactatata ttctcgctat 180 gtttagttga ttatacgatt taggggttta ctttaggtat tttgagcatt ttcaattcat 240 gcgattgtcg ttgaaataac aattgggttt tagctttgct ttagctgccg tgacttttgt 300 ttgtatctct ataaatttat caatattctc cgattctaat tgcgttgggg gtgtggttgt 360 ttattcgcag gacttctcac gtagttgtct ataatttgcg gtctcttaat tggcacagtt 420 ttagttttag ctttagctcg tcgattttgc gaatccctat gtacacgcat agctcagtga 480 gttgcagtga ttgccatttt gaataattta tttgtggtta tttcttttcg tgagcaaaat 540 gctttacggc ttacagattt tcgattggcg tacgtacata catattacat attcatatac 600 atttatcgaa atgagtttac aacctgtgct taatttagtc gtacaaaaat actcagtatt 660 tacaacaaga tataaacgac ataaaatcat aaataaataa gttatcctat acaaagtccc 720 gatctgtgct ccaaggaacc cggcaaactc gaattgagat taaatgtttt aaaaacgaaa 780 acaaaaatga aaaaatgtga agaaaatgaa atggcacgct ccacagattg aataatgtca 840 acattacgag taaatcagcc gacgcatttg ccggcatatt aattttacaa attaatggaa 900 cactttaatt gcattaaatt gattccaccc atccggctgg catcgattga ttcgattcgc 960 atccttacac cagtcgcacc atttgcacca tttgcaccat ttacacatga ctcgaggccg 1020 tcgaggcggc ggcattgttg ttcttgttcc atttgttgat gtactccatg ggtatttcaa 1080 tctggatctc ctgcacatcg tcgcccgcca agcaatcgac attggatttg cccttgcccg 1140 catccttgcc cgtatccttt gcatccttcg actccctgcc atccttggcg gcagctgcca 1200 attgtccgcc caggcgggat ccgcccgccg ccagccgctg ctgctgctgg gcgatggggg 1260 tcagcagcgc ctcatccctg tattataagt tgtccaccat ctgagactgg cggcgatgcg 1320 agggcgttgt cgagttaagg tagctctccg agtagacgct cttcgcccgc tggtcgtagc 1380 gcaggctgga gcgccggatg tcgatgtcca gaggcaggtg gcgatccttc caccaattgc 1440 agaacaggca gagcagcgtg ttgcggaacg cctcccggaa gtcgcggttg aagtacgcgt 1500 agatcagcgg gtttagcgtt gagttgaagt acccgatcca gaagaggatt gagacgacta 1560 tgtccggcac ttggcactcc tcgcaggtca tggagagtgt gtacctaaaa ttaaaacaat 1620 ataattatta gcttacactc attatcttta acttaattta agtcaatttt aaattagttg 1680 cacaggtaat gcaattttat gtactttttt tttcccggca ttgcataata tctatttttt 1740 aataatacaa aagcaaatat aaaagatcaa atgaatattt ttgtttcata aaagttaaac 1800 ctcataaacg atctatattt gaatactttg atcaccattt gaaatctttc tgcatcactt 1860 tttgtctgtg tagcacataa agatgagata tatataccca taaattccag atgcatgagt 1920 gggccagggc tttgcataaa tgagattata ctctgggtgg tgtgaaaaac aacaaccgcc 1980

239 gaaacaatgg cgcacgggcc gtatgagtaa tatttaatta tgcatgcttg acattagata 2040 aattatgcct ggaatcccat gtcagcggga ttggcctcca actctcaacc aaacgttcaa 2100 ccttcgacgg ctggttggta ctcaccacag gaagaaaggc agccagcaga ggatgaaggt 2160 gcccatgatg atgcccagcg tgcgtgcggc cttgtgctcc cgcttcattt tgattaagtg 2220 cttgtcctta gtgggggtgt gctcctgctc gacctcgtgc agcgtcaatg ttttcgacga 2280 cccggatccg ctcagcgcct cgcctgccgt aggagataag atggagattt gataaaagtc 2340 caggctggag atgggccact gaactcaatg cactcgcact gcatcactgt ccaggatgct 2400 tgtagaacaa actagtgatc tttcacgctc actacctgtt tgctattcag aaagtaataa 2460 gactttctgt cctggtaaat ttatattttt gaagtattat ttccacttaa aacccattat 2520 atatattcaa acaaacattt ctttacagcc aaactaggta agccttgttg tttacaaccc 2580 aactttgact ccaaactcac ctgatggctg catggatggt cggtgcatca gcatggcatt 2640 gccgtgccgc atcatcagct gcttctcctg ccgattggct tcccggaaga tggccaggta 2700 ggtgaatatc ataatggtgc agggtatcca gaacgatatg gagctcgaga tgacggcgta 2760 gtacttgttc accacgaacg agcactgcgt cggattctgg atgacgaact gctggtgctg 2820 cggcgtggtg taccagccga tgaagatggg caagaaggag agcagtgccg gcgatatcca 2880 tgtgtttagc agcataatgc cgaccacgcg tttcgtcatg ctaatcggat acttgagggg 2940 cttaacaata gcatagtatc tgtgaagtgg gcaaaacgcc aggttattgg gccctcatat 3000 agctatagtt ctggctgtgg catgcaactt acctatccac agatatgcag cataaatgca 3060 aaatactcgc tgttgagaag tagacatcga ggctgttcca caaatcgcac aggaaggggc 3120 tgaagttcca cctgaaaggg tccaatgaat ggaggcatta gtatcgcgat gcttacccaa 3180 taacgaggca ataaactttg gcctttactt tctaacgtca ttgtatctga ttatcgagtc 3240 catgaatttg cagtatatat ttttgttgac tcatttctgg ttttttgcct cacctaaaat 3300 gccacgcgaa atacttttat gaagtcatcg ctttaaaact gatttcctgg tttttagctg 3360 tgcaaaaaat ttagtttttc acgattaatt ccctttgtga caacacagtt atttacgtac 3420 tctgattaaa atcatttgat tgtgggtaaa attgcgctag ttctaatatt tactaccatt 3480 taaaatacag atatataggc cataaaaact cactagatat gcgcaataag gttgctctaa 3540 atttaaacgg cattttactg ccaattcctg aatgtaggtc tataaaaaac tcaaactgac 3600 tagacacact ctctttttcg cctattttcg ttatcaggcc gcctgattta tgtgtttatc 3660 gatttcatct tagtttcggt tgccaggtga cattgcccct gaactgccat tctggagggc 3720 caaattaaaa gcttagatgc actgtgagac cagaaaatag gccataaggc ccgaggtgaa 3780 aagtggcaag gaaagcggag gcgactctgt tcgctgcatg aaaaactcat taaaacttgc 3840 gtcgtcgctg ttcgcctgtc gcttctgccg tcgcccttgg ttgccactcc gcattttggc 3900 catttcggtg aaggcggata cccggccttt ttggggccag gagccagtgg aatttattat 3960 cgggcgcccc gtttggcatc agtttcaaaa acttttcgac tatccaacga ggctgttttt 4020 gctcgctggt ttttggtgct ttacactaca ttgccatttg gggcgggcgc gccatcggtt 4080 ttgacactta agccatgaaa tggcagttcc tcgtgctgca attatgcaac tggcaactgt 4140 gaaggtaaaa tgtctaatga atgccaagtg gcggcgagtt ggctgttgcc agaaccaaac 4200 cgatgccaat ttatatgcaa ctcgcgcttg gccaaagttt ttc 4243

<210> 185 <211> 1224 <212> DNA <213> Drosophila

<400> 185 atggactcga taatcagata caatgacgtt agaaagtgga acttcagccc cttcctgtgc 60 gatttgtgga acagcctcga tgtctacttc tcaacagcga gtattttgca tttatgctgc 120 atatctgtgg atagatacta tgctattgtt aagcccctca agtatccgat tagcatgacg 180 aaacgcgtgg tcggcattat gctgctaaac acatggatat cgccggcact gctctccttc 240 ttgcccatct tcatcggctg gtacaccacg ccgcagcacc agcagttcgt catccagaat 300 ccgacgcagt gctcgttcgt ggtgaacaag tactacgccg tcatctcgag ctccatatcg 360 ttctggatac cctgcaccat tatgatattc acctacctgg ccatcttccg ggaagccaat 420 cggcaggaga agcagctgat gatgcggcac ggcaatgcca tgctgatgca ccgaccatcc 480 atgcagccat caggcgaggc gctgagcgga tccgggtcgt cgaaaacatt gacgctgcac 540 gaggtcgagc aggagcacac ccccactaag gacaagcact taatcaaaat gaagcgggag 600 cacaaggccg cacgcacgct gggcatcatc atgggcacct tcatcctctg ctggctgcct 660 ttcttcctgt ggtacacact ctccatgacc tgcgaggagt gccaagtgcc ggacatagtc 720 gtctcaatcc tcttctggat cgggtacttc aactcaacgc taaacccgct gatctacgcg 780 tacttcaacc gcgacttccg ggaggcgttc cgcaacacgc tgctctgcct gttctgcaat 840 tggtggaagg atcgccacct gcctctggac atcgacatcc ggcgctccag cctgcgctac 900

240 gaccagcggg cgaagagcgt ctactcggag agctacctta actcgacaac gccctcgcat 960 cgccgccagt ctcagatgca gcagcagcgg ctggcggcgg gcggatcccg cctgggcgga 1020 caattggcag ctgccgccaa ggatggcagg gagtcgaagg atgcaaagga tacgggcaag 1080 gatgcgggca agggcaaatc caatgtcgat tgcttggcgg gcgacgatgt gcaggagatc 1140 cagattgaaa tacccatgga gtacatcaac aaatggaaca agaacaacaa tgccgccgcc 1200 tcgacggcct cgagtcatgt gtaa 1224

<210> 186 <211> 407 <212> PRT <213> Drosophila

<400> 186

Met Asp Ser He He Arg Tyr Asn Asp Val Arg Lys Trp Asn Phe Ser

1 5 10 15

Pro Phe Leu Cys Asp Leu Trp Asn Ser Leu Asp Val Tyr Phe Ser Thr

20 25 30

Ala Ser He Leu His Leu Cys Cys He Ser Val Asp Arg Tyr Tyr Ala

35 40 45

He Val Lys Pro Leu Lys Tyr Pro He Ser Met Thr Lys Arg Val Val

50 55 60

Gly He Met Leu Leu Asn Thr Trp He Ser Pro Ala Leu Leu Ser Phe 65 70 75 80

Leu Pro He Phe He Gly Trp Tyr Thr Thr Pro Gin His Gin Gin Phe

85 90 95

Val He Gin Asn Pro Thr Gin Cys Ser Phe Val Val Asn Lys Tyr Tyr

100 105 110

Ala Val He Ser Ser Ser He Ser Phe Trp He Pro Cys Thr He Met

115 120 125

He Phe Thr Tyr Leu Ala He Phe Arg Glu Ala Asn Arg Gin Glu Lys

130 135 140

Gin Leu Met Met Arg His Gly Asn Ala Met Leu Met His Arg Pro Ser 145 150 155 160

Met Gin Pro Ser Gly Glu Ala Leu Ser Gly Ser Gly Ser Ser Lys Thr

165 170 175

Leu Thr Leu His Glu Val Glu Gin Glu His Thr Pro Thr Lys Asp Lys

180 185 190

His Leu He Lys Met Lys Arg Glu His Lys Ala Ala Arg Thr Leu Gly

195 200 205

He He Met Gly Thr Phe He Leu Cys Trp Leu Pro Phe Phe Leu Trp

210 215 220

Tyr Thr Leu Ser Met Thr Cys Glu Glu Cys Gin Val Pro Asp He Val 225 230 235 240

Val Ser He Leu Phe Trp He Gly Tyr Phe Asn Ser Thr Leu Asn Pro

245 250 255

Leu He Tyr Ala Tyr Phe Asn Arg Asp Phe Arg Glu Ala Phe Arg Asn

260 265 270

Thr Leu Leu Cys Leu Phe Cys Asn Trp Trp Lys Asp Arg His Leu Pro

275 280 285

Leu Asp He Asp He Arg Arg Ser Ser Leu Arg Tyr Asp Gin Arg Ala

290 295 300

Lys Ser Val Tyr Ser Glu Ser Tyr Leu Asn Ser Thr Thr Pro Ser His 305 310 315 320

Arg Arg Gin Ser Gin Met Gin Gin Gin Arg Leu Ala Ala Gly Gly Ser

325 330 335

Arg Leu Gly Gly Gin Leu Ala Ala Ala Ala Lys Asp Gly Arg Glu Ser

340 345 350

Lys Asp Ala Lys Asp Thr Gly Lys Asp Ala Gly Lys Gly Lys Ser Asn

355 360 365

Val Asp Cys Leu Ala Gly Asp Asp Val Gin Glu He Gin He Glu He

241 370 375 380

Pro Met Glu Tyr He Asn Lys Trp Asn Lys Asn Asn Asn Ala Ala Ala 385 390 395 400

Ser Thr Ala Ser Ser His Val 405

<210> 187 <211> 11847 <212> DNA <213> Drosophila

<400> 187 gtgaatcgtt tttgcagcga atggcgaaat ttcctacagc ttgccaattg ttttggttgt 60 tcgcagttca ttctttttac tcattggtaa gattgtcttt ctgcatgaaa attcataacg 120 tcagctacac aattctcttc cattcaatat tttgtccata cataatttcg attgcgtaat 180 ttgtaatttt caataactct gttatgtaga tttggtttgc tagttttcta ggttacatat 240 gtatgatact tagagctaga ggtaacatta tgggattgca ctttttccat gatttaggct 300 agttctatct gtaacaacat taaaaagtgt gtttaatatg aaataaaagc agggagttca 360 ttccgctcag gatttgcaat cctaatatac gatgatgaca catgtgaata atccaatttt 420 ggatcgtatt aatactccaa aaatcgatgg aaaaagtgtt tcgccttcga caagccgaag 480 tggtgtacat aattcttaga tgattcattt gacaacattt cacttgaagt tggaactttt 540 ctacgcaaag agtcgctcga tttctaattg gctttcgctc tgccatatat gtatagttat 600 tacgtatatc ttctgtttag ttggacaaac aacacttata tatggatagt atagttccgg 660 ggcagcattg tccctgcagc cgcggcttgg cgggcttaga acacaacttt aatttaaatt 720 ccctatcgtt gcttaaacga aattgtacac gtatacataa acacacatcg agtattgctt 780 agcttcaagg attatgctag ctatatcctg gcacaaatgc cactggtatg gccgttgctc 840 ttgttacttc tcttcacttc agctggtgtt ttccctcctt gggcacatat acatgtgcga 900 cgattcactc aagtattaaa tatcacttat aggggcattg ttccgcatcc acgagggtgg 960 acgaagcagg aatgtggccg ggatgcagac gctatccggt ctagacgtag taggcgttgt 1020 acggatttcg tttctccaga cagggcagca cacactccag cgtattgcgg aatgcctcgc 1080 gaaaatcgcg attaaagtag gcgtatataa gcggatttag cgtggagttg aagtaaccga 1140 tccagaataa caccaccacg agcacatcgg gacatgggca ggccggaccg cagagcgatg 1200 tgatgacata cctggaagga ggagtgagaa tcacatgaat atgagtcacc agaaaaagaa 1260 gaataagaag gccaacaatg gattacggat ggcggtacca catccgtacg gcctatctac 1320 cgtcactcac cacagaaaga agggcagcca gcagagcaga aagacgccca tgatgatgcc 1380 cagggtgcgg gcggccttgt gttcggcctt ccatcctttg gccggtcgca cggaaccgcc 1440 tgtggggcag atagagagtt tagaagggat atgaaagctg gcaattggct gattaagttc 1500 aattcgaatc gattcgtttc gatccgccag tctgtttttt ttcttttgtt gggtcatagc 1560 aatcgacagt tttctggttc atttctgtct gtctgcgaaa gcactcgaaa aatgggtttc 1620 tttttaagta gtctataata tgcttaatgt ggtatttgtt gtctacctgt tggatgtgtt 1680 tgttttatgg tttattgctt ctaggatgaa attgtttata cagctaatac tggaaagtat 1740 aggtgtttgc ttaagcttta atcggcgata cccttttatg ttaactatgt atgtaaatta 1800 attgaacttc aatcaattaa aatacagaaa atttcaaaca aacaaatttt aaagaggtaa 1860 ctaaactaat cttaaaaatt attaaatatt ttctctgtgt gtaaattgcc aagaaatgcg 1920 gtttatgttc gttttattgt gagagaaaga ttatgccggc atgttgcgta tacgccatgt 1980 gtgtggtatc cttgtttaac tttgacatta gtaatacttt tgctgttata tgttgttggc 2040 tatcgatggc atttcaaacc ccacaccgcc ccgctccctg cgtccacctt gcaagtgact 2100 gtcattaaag tgctggaaag gccaacatgt gtgcagtatc ttggtgctcg ggcgtgtggg 2160 tgtgcgggaa aagcaataaa aacgaggcaa acaattgaaa atatttacac aggacacttg 2220 ttatcacaaa gacatacaat cccccgcatc catccagtcc agtgcgcccg ccccaaacat 2280 aaacataaac atcactggcg gccaggagga aaaacaaatc agacagacaa cagtgagcaa 2340 caggaagcaa cggaccatcg cccttgttca cccattgccc atcgcccatt gcccatgttc 2400 ccccatccag tttgccacct ggatcccttg atggacgcca ctcggtgatg gccacagcca 2460 ggtgaaatca taatgcaaag gctgtgtgga gggaggcgta ataaagcaaa gcaaacgcac 2520 gtgcaaacgg aagcaattat gtacagcatg agagcagcga aaggtgaagg attcggatac 2580 ggattcggag gcagattagg tggaggtgga gacagcatga ggtttcgatg gtgtaacact 2640 ccggattcag ttgcctaagc tggttagctt ggcatccgga taaggaggtg ccaaaaaact 2700 ggcacttctg tgggtatttg ccactaaagc tgggggctac aaaaatttga ggtagttctt 2760 ttcggtttca tttcacggtt gatttaatga tacttaggtt aaccaccgtt gaaatgattg 2820

242 ggattgcaga aattcaggga tatctattct agtatgattt ttggtaagaa cgttaactag 2880 tttcaggtgt attcaaaagc tttcaatttt aaacataata ggtttaaaca tatacggaac 2940 agtaatattg attgtttttt gactgacagg atatttcata tgaaataaat agatttttga 3000 tatgtttggt ctaatgcagt ggcataaaat acgaagtgaa tgggacttga tttgattaag 3060 attttctgat gattatatat gtattgatat agagaaacta taactattgg tgttgtgaaa 3120 ttagtgaatt ctgagtgtga aatgtattat aatataatgc acaagttctg gactgtggga 3180 aatcgaatga ttcagatgga taatgggtag caatgagata ggtgctgaag ctgagacaag 3240 cagaaagaca gagatagaga gagaagcggg agagaaagag cgaaacgtag agactggggg 3300 aggagaggag gggagatacg acaagactca ccggttgcac cacagtgact gcatccggtt 3360 ttgaagcggc gcttccggtt cttgctctgc tgccaacatg ctgtgaccgc cgccgttcgc 3420 ttgtgccaga atcgagtgga actggacgag gaggcgggcc tctggccaag atctggagtt 3480 tgctcgtgaa tactacgttt actactagtg gttactgtgg tgtcgattgt gctgtcggcg 3540 ttggcggttg cggttgcgtt tgcggtggtg ccggtggtgc tgctgatgtc ggcgccgcag 3600 agcggacact tgggcagcgg actgggcacc gcggcgaagg tgatgccgcg gggccgctgc 3660 tcaatgatct ccgcctcctc ctcatccaca aagatgcaga tgccgccgcg tcggatcagc 3720 gaggatttat tggaaaattc gtgctctgct tgcagttgat tgttgcattt tcgtacgatt 3780 tcgattgtca atttggccat ggcatttttg gggttttatt ggttggattt ggttttggag 3840 tagaagtagt ttgtttgttt ggttggacat aatttggtga tttcgattta catatataca 3900 catacaacac acaacgaaat ggcgtggaag agagatagat ataaagagat agagacaagt 3960 agtaaacaat gtacacaggg tatttcacag gatacgaaag gacttcaact tctgagatca 4020 catgcagcca tgcaccggca aacgcaaagg atcgggatcg aaaagggaat ggattcagat 4080 tcattatcgt tggctccctg tctctggaag taggtcgtcc ctttctgtct tcgtttgcag 4140 gtgcaactaa ctaaatgcta tacattatat tatatatata tagtaagcta gttaactaaa 4200 gtttcattcg aagcatttga gtattacttt tccaatgagg gtttataggt tctatacatt 4260 ttaaaacact gtatgatttt tcagaaattc gcaccgcttt tgaaaggaac ttaaatacac 4320 aattcacagt tttcttcaag gtaagaacta tatttaaata tggtaaaagt tcgtatcttt 4380 attttaagat caaaattcta gtaagaccag attccttatg ttaaacccga attcaggcca 4440 attactcctc aaaaaaacaa ggacaaaaga atgtgcgaaa aagttaagtc aaacattgaa 4500 acacttgaac ttttcgtgga aaactgacaa aaacagaacg aatttctctg gggcagatat 4560 aaattgtctt aaaagagcta cttaaatcaa gcacgagcta tacagtctac acaatgacca 4620 aatggatgac tactcacttg cggaactggt ggaaacgcgg cccatcggga tgtagctgcg 4680 actgtcgctg ttctcctgcg agaagttgat gacattcacg tcgtaggtca ccacggacgc 4740 ctgtctcttc cgcacagttt ggatgccatc gtagcctgcc aggatgctgc agcggccttg 4800 gcggccaccc actcctccaa cgccaccagc ccctccattg ccggaaacgc tcacgtccgc 4860 atcgccggcg ctatctttgc gcttgaacag tggcgacgtg acatcccggt gctcatcgcc 4920 gcatccctca accggcgaca gcgtggaatc gagtatgatc tccggcttgg gcgatatgtt 4980 ggactgtgag gccatttggg gatttggctg cggcactgga acgggcatag gcaggctggt 5040 caccacatcc aaggacacag tggatgtgtc actgggcgta taaccaggtg cggcggcatg 5100 cggcggcggc gataggaagt acacattgat ggacgccgac tgcgcgttgg aagaggcgga 5160 agagtccatg gcacctccgt tcggcacgga aatggccggc ggagccggtg tgttcggtgg 5220 ggacatcaga tagttggcgc acacctggtc actgagcgtg ctcaggcgct gtggagcacc 5280 agccggtcgg cccagcggaa agctcagcga gcgaaagatc tcggccagtt ccgagctgct 5340 ggcaatgagc aggccactcg gttctggcaa ttctggcggc gataacgatg gtggcggcgt 5400 ggccggctgc tggggcgact ccccaaagca atcggccagc tgcgccaact cgtcgtcgct 5460 ccgaatcctc tcgggcggtg ttttcagctc actgaagtca atcagctgta ccccgtcgct 5520 gaactgctgg atcacactgg ctccactctg ctcgctgagc acattgatgt ccagcaggat 5580 gtccggcttg ttgggcgtgg agtccgtatc gctgtgctgc cgctggcgtc tctcaagttt 5640 gcgttccttg ccgccaccgc atccgttgta gctgtgcgac aatttccggt tccgggagcg 5700 ccggaagaag ctggatccct cggagttggc ctgatgtcgc ttcttttcca gcgtaaagca 5760 ctcggtgctc gagcgtttcg tcttcgacag cagggacaga atgttgaagc ccttctcctt 5820 cccgggcact ggctgctccg gcaacgcccg cgattcacta atggtgcgca ggaactccga 5880 atcgctggag gcgaatgcct tacgcccaca ggccgctgcg cccgccttca gcctgatgaa 5940 gtccgtttca ctgagggcag cgtactttcc tccgcctggg ccactgataa tggtgccgcc 6000 cgtctggcgc ttaaagtaca gatagttgtc ctctatcagg cgcttcagct ccttgttgtc 6060 ctcggccagc ggcaggtggg tgtcgtacag gtcgttgccc tcgctctcgt cgctgttgag 6120 accaccaaag acccggtacg cagtggactc cggttccggt tcgctgttcc cactgccgct 6180 ggtcaggctg agctgctgtt gcgggccatt gggatgagaa tgctccttat cgagctcctt 6240 cgaagggatc atcttgccct ccgtccatat ctgcggattg aacactggcg ccggtggctg 6300 caactgattg tgggagggct gctgttgctg cagtgccatc atcgagggag cactgtccgt 6360 gtgggtgacc ttctcgtacc gctcctgctc caagtccctc agatcgatgc tgctgcggct 6420

243 gaggcggcgt ggcggcggcg atggcactct cagttcatcg cactcgtccc tatcgtcgtc 6480 ctcgtcggtg gccggctgca gcatgtcctg tgggcaaagg acaatcactc aaagggaagt 6540 catggtggcg catcaattac gcacagccac aagggaaaag gaaaaactct caagcggagt 6600 gcttccctct agcacctaat ctaatcgctc cacatccgtt cattgaggat gggcaaaaag 6660 ctttagagca ggatgtcaat gttgcccgtt tgtatacatg aactgcattg ctttaaagtc 6720 tttgtatatt tatttaggat actatctgga tgtatcagca actttaccaa attttactca 6780 ataaaaaata aataatgttt tattcaacta ctaagagatc ttcagaatgg caagcaaatg 6840 cgagtactaa agcatttatc ggtttaataa aaataaaaca tttttaagta tctctaggta 6900 ttttaggcat ctttggatta atgtgtattt tttcattttg aacatctttg aaatgtttat 6960 tgtttattga atgatttatt gaatttatat caataaaatg cagcaaaata ctcttttggc 7020 tttcaataaa tgacatctgt atcttttcgg ttcagtaaca tttagtaacc ttccaaactc 7080 acctccaagt tactaagcgc actgtgcgtc tcctcccggg cggatgtggc attcagatca 7140 cagtcactgg gatgcagata gctcaggctg gtgggctgct gggtgtggcc catgtggacg 7200 ctgttaagga ggatgttgga gctggtgcgg ctgagggcct tgcgttgacg aatcgcctcc 7260 ctggaaaacc acagagcaca gatcagcaat taagcaaact catccactac gaccagcgac 7320 catcgaccat cgaccatccg ggtaagaact cacttaaaga tgcgccagta catcaccagc 7380 atcacaatgc cgggtatcca gaagctcacc gaactggaga tgagggcgta ggccttgttg 7440 accacaaacg agcactggtc cggatgcagg gaaatctccc gcaggtgctc ctccgtcgtg 7500 taccagccca gaaagatggg cgtgaaggat atgagggcgg gcaggatcca cacattggcg 7560 agcatgaagc agaccgtttt gtgtgtcata ttcaatggat actccagtgg acgcacaatg 7620 gcgtagtatc tgttaaaaag aagagggggt catctttatt aatggaaatg aattgcggac 7680 aggtcctccg cacaaaggtg ccaggtggct ttcagccatt tcctccttct cctcctcctc 7740 cttttggctt actaattgat tatcgctctt tggttggctg aataattgtg tttcggtact 7800 caggttgcca tgcacagaaa tcgatttatt aaccttttaa agatcatgtt gcatttaaat 7860 gaaggataaa tgctcttaac cgaattcatt atcggaatcc gtgaaaataa ggtggtgtat 7920 tctttttaat tatcaatata ttaataaatg caattgaaat gaaataatta ttaatccacg 7980 tatattgtac ctcattattt tatcgaaact taatgctcct tttaaagagt aatgattatg 8040 tttggaacat tacagattta ttagtttagc caaatttccg ttagtggcca tcattaattc 8100 tctaattttg ataggttctg gttgaatttc cctttgtttc ttggtatgtt ttgtggcccg 8160 tcgaaaggtg agtgaaacac aaattaatta aaacagacaa aaggcccatg actccagtgt 8220 ccatcgacca tccctccatt gttgctggtc agcccgaaaa tcgcagctgt tggtgccttc 8280 caagtgggga atggcgccaa ttaacggctt gacaggatgg agaaggttgt gggagttggg 8340 tggaatatgg gtggaatatg ggcaacgccc acgtttcggc cagctgcaaa tcatttgggc 8400 cgcattcatc atacgggcgg gcctaatgtt tgcttttgat gtgcgcgcct ttcatagtaa 8460 ttaattgttt cttcttggca attcgccggg ctttggtatt gaaagtgatt tggttgccag 8520 gcatctgggc aagattaatg gtatttggcc aaactaaacg gctttcttca gtaccatagc 8580 ccagcacaat tgactttaaa ccgcttaata tatagataga gagcgacata aatgggcact 8640 cacctgtcca ctgatatgca gcacaggtgc aatatgctgg ccgtggaaaa gtaaacatcc 8700 aggctgttgt acacgttgca catgaacggt ccgaacatcc actttccgcc ggacagttcc 8760 acggaggcgt tgaatgtcat cgcacagagg gccaccagca tgtcggccat cgccagcgac 8820 acaacaaagt aattggttat caccctgcga acgaaacaaa agcccaggaa tttgtgaata 8880 tggcgtggtt ctgggcggga tttgaccagc ttctccccac atctaaccac ttgtcacagc 8940 gcaaaaccac gccaaacgta atggcatatg gcatgcatca tatgtgcaca tgccgctgta 9000 ctaagcgctt tggttggctc cttccgttgg ccaagcagtg caccactgct ttccatttcc 9060 tgttccggtg ttcaggagtt tggaggcaat aggtcaccgg tatgcagcaa tttccttggc 9120 tgtcataagt cactcgactc accaggcagc tgccaccttc agctgcaagc tactggcttg 9180 tgaagttatc atcttgtctt cggggcgtat gtggtttaag gagctgttta tgcgaagatg 9240 aaagcacttt tgtgcttcca agtcatttat tacatattgc gacatctatt acgttggaaa 9300 gtgtagtttt acaggggctg acaacattgt ctaaaacatg ttattaacgt atattgtaat 9360 attgtagtaa tgaagctcaa ttaaatcaag attattaatc tgtgcattta gaagggctgt 9420 taatttcgaa agatcctttt atgtcaagcc gttttttctt ttatgcactg ctttattttg 9480 taatatctca acgcaattct atatggcgaa cgttctatcg taaggtagta aatgataatc 9540 tgagcacttt aagctccttt agcggtataa taaagacttt aatcaacatc tacccttgct 9600 gcagaaggca taaacgttgc gcaacattaa acggatgtcg tgggtgtacg tgtgggggcg 9660 tggccggggg cgctggcggt ggcagagcgc tcaatggtat gctacactta tttgcactgc 9720 actctggggc gtcctgtcat cgcgacgctg acatggcagc gatgggcttg ggatcggctt 9780 gtgtgccgca tttaacttcg ttttgttctt tattattcca cttgtcgctc atttaaatta 9840_, catttatcgc gatggcgaaa aggattcgcc ctgccgcgtc actgtttgtt tgccatttcc 9900 attgtcctgc gacccttgcg gcaatgaccc tcaattaaac tcagttacag gtggtgaaaa 9960 caaaagtaat tggatataga cttaccgcag ctttcgattg cgctgcactg aaatgatgac 10020

244 caatgcattg ccgaggacag cggccaggat aattgacgag aagatgaatc ctttgagcag 10080 cagcagcgat agatccagcc agctctcctc cagctccgcc tggttatcca ccgcaatgtc 10140 actgccattg gccgttatat ttgggccgac tgtcgagagg agctcaaacg tggaatccga 10200 cgacaagtag gatgaaaagg gcgaggagta ggaggcatct gacgatgtgg ctgttaatga 10260 tagcgaagtc aacgaggcat ccacaaattg cgatgttata ggcaaactgc tcgtcggcgt 10320 cgtcgtagtt ttggctgctg ctgtcgtgga aatgtggcct gttaatgttg caggttgcag 10380 gtggctggcg ttggtggctg atgttgctgc tgcttgtgat gttgctgctc ctgctgcggc 10440 tgttatgggt aatgtcattg tcgtggccag aaggtcagcc acgttaaccc ctgacatctc 10500 gtcgatttcg cagcccaatt gagtcgcagc tcattcaagt tgctccgcca atgctttttc 10560 gctgtacttg tcgtttatct ttttcccggc tgctgtgcgt aatttaaaac tcgagtaatt 10620 gcaatctgca atgcaaacaa ggctgccgaa gtttgccgtc atcctggttg ccaatgttgc 10680 tcctctgcga ttccagtatt tgctcacagc tccgactgaa ggtctctgct ccatttccca 10740 atcctccata ggacgctttt cccgtttgag ttgctggaaa ttggcaaaaa gtcgagactc 10800 gcgcttcgat ttggcactca agcgcgcaac agtcggcgac acgggaactg caaatgaata 10860 aataaataat ttatgaaata atcggcgagt gtgaggctgt gaaactgcat ggcaaaattg 10920 gtaaaatggg aattcgaacg gttgcgccgc ccggggtgtt tttatgtaca tacgcaatat 10980 tcaacagggg gcataaaccc tattgcctat ttatgtgccg cagtaacaca taaatgggat 11040 tcttctgttt ctccagtgcc ccgtcaaatg tccgttcgtt aaaagtgcgc cacttcaact 11100 ttgctacact agattaaaat aacagaaata tattgcgtat acgcagtgtg tgcactcggc 11160 atgcatctgc atttctatat ccccagcgag acagcggtgc tgtcaagtgc tgacacttgt 11220 gcagagtgga atgtggaata tggacaagtt gttgctttaa aagtgagatt aaagcaagat 11280 tatcagtggg aaagttgttt cagtagtgcc tcacgcctgg gcgcagtgaa aactgcaaat 11340 cctttttgtc ccggtacttg taagtaaaac aaaagactct tcataatctg tggtaatctc 11400 gaattttttc ttttttatta ttttaaactt tttgcgactc aatttggccg taaaaatgct 11460 aacacatcat cagggaaaag ctgaaagcgt gcttacactt tactttctcc cccgcaacat 11520 tgaattgaag ctgaatccgt ccttggcact cagacaaatc gctggctaca cgttttcatt 11580 gcacttattc tgtgcactct agatgccctg ccctcattcc aatcttcaga gttttgaatc 11640 taatattttt aaggatttat gtacttatac agataacctt gccgaattga ttgcattgcg 11700 ttgtccttga gctgtcgatt cgacttgttt actcagacca tccggtcaca tcctcctgct 11760 agattggcaa cttaatgttt taatgctcgg acttaaacca catcagtgcg ctctatcatc 11820 cttggcttat acatttcaca agccatt 11847

<210> 188 <211> 2092 <212> DNA <213> Drosophila

<400> 188 ttcccgtgtc gccgactgtt gcgcgcttga gtgccaaatc gaagcgcgag tctcgacttt 60 ttgccaattt ccagcaactc aaacgggaaa agcgtcctat ggaggattgg gaaatggagc 120 agagaccttc agtcggagct gtgagcaaat actggaatcg cagaggagca acattggcaa 180 ccaggatgac ggcaaacttc ggcagccttg tttgcattgc agattgcaat tactcgagtt 240 ttaaattacg cacagcagcc gggaaaaaga taaacgacaa atgtcagggg ttaacgtggc 300 tgaccttctg gccacgacaa tgacattacc cataacagcc gcagcaggag cagcaacatc 360 acaagcagca gcaacatcag ccaccaacgc cagccacctg caacctgcaa cattaacagg 420 ccacatttcc acgacagcag cagccaaaac tacgacgacg ccgacgagca gtttgcctat 480 aacatcgcaa tttgtggatg cctcgttgac ttcgctatca ttaacagcca catcgtcaga 540 tgcctcctac tcctcgccct tttcatccta cttgtcgtcg gattccacgt ttgagctcct 600 ctcgacagtc ggcccaaata taacggccaa tggcagtgac attgcggtgg ataaccaggc 660 ggagctggag gagagctggc tggatctatc gctgctgctg ctcaaaggat tcatcttctc 720 gtcaattatc ctggccgctg tcctcggcaa tgcattggtc atcatttcag tgcagcgcaa 780 tcgaaagctg cgggtgataa ccaattactt tgttgtgtcg ctggcgatgg ccgacatgct 840 ggtggccctc tgtgcgatga cattcaacgc ctccgtggaa ctgtccggcg gaaagtggat 900 gttcggaccg ttcatgtgca acgtgtacaa cagcctggat gtttactttt ccacggccag 960 catattgcac ctgtgctgca tatcagtgga cagatactac gccattgtgc gtccactgga 1020 gtatccattg aatatgacac acaaaacggt ctgcttcatg ctcgccaatg tgtggatcct 1080 gcccgccctc atatccttca cgcccatctt tctgggctgg tacacgacgg aggagcacct 1140 gcgggagatt tccctgcatc cggaccagtg ctcgtttgtg gtcaacaagg cctacgccct 1200

245 catctccagt tcggtgagct tctggatacc cggcattgtg atgctggtga tgtactggcg 1260 catctttaag gaggcgattc gtcaacgcaa ggccctcagc cgcaccagct ccaacatcct 1320 ccttaacagc gtccacatgg gccacaccca gcagcccacc agcctgagct atctgcatcc 1380 cagtgactgt gatctgaatg ccacatccgc ccgggaggag acgcacagtg cgcttagtaa 1440 cttggagcgg ccccgcggca tcaccttcgc cgcggtgccc agtccgctgc ccaagtgtcc 1500 gctctgcggc gccgacatca gcagcaccac cggcaccacc gcaaacgcaa ccgcaaccgc 1560 caacgccgac agcacaatcg acaccacagt aaccactagt agtaaacgta gtattcacga 1620 gcaaactcca gatcttggcc agaggcccgc ctcctcgtcc agttccactc gattctggca 1680 caagcgaacg gcggcggtca cagcatgttg gcagcagagc aagaaccgga agcgccgctt 1740 caaaaccgga tgcagtcact gtggtgcaac cggcggttcc gtgcgaccgg ccaaaggatg 1800 gaaggccgaa cacaaggccg cccgcaccct gggcatcatc atgggcgtct ttctgctctg 1860 ctggctgccc ttctttctgt ggtatgtcat cacatcgctc tgcggtccgg cctgcccatg 1920 tcccgatgtg ctcgtggtgg tgttattctg gatcggttac ttcaactcca cgctaaatcc 1980 gcttatatac gcctacttta atcgcgattt tcgcgaggca ttccgcaata cgctggagtg 2040 tgtgctgccc tgtctggaga aacgaaatcc gtacaacgcc tactacgtct ag 2092

<210> 189 <211> 603 <212> PRT <213> Drosophila

<400> 189

Met Ser Gly Val Asn Val Ala Asp Leu Leu Ala Thr Thr Met Thr Leu

1 5 10 15

Pro He Thr Ala Ala Ala Gly Ala Ala Thr Ser Gin Ala Ala Ala Thr

20 25 30

Ser Ala Thr Asn Ala Ser His Leu Gin Pro Ala Thr Leu Thr Gly His

35 40 45

He Ser Thr Thr Ala Ala Ala Lys Thr Thr Thr Thr Pro Thr Ser Ser

50 55 60

Leu Pro He Thr Ser Gin Phe Val Asp Ala Ser Leu Thr Ser Leu Ser 65 70 75 80

Leu Thr Ala Thr Ser Ser Asp Ala Ser Tyr Ser Ser Pro Phe Ser Ser

85 90 95

Tyr Leu Ser Ser Asp Ser Thr Phe Glu Leu Leu Ser Thr Val Gly Pro

100 105 110

Asn He Thr Ala Asn Gly Ser Asp He Ala Val Asp Asn Gin Ala Glu

115 120 125

Leu Glu Glu Ser Trp Leu Asp Leu Ser Leu Leu Leu Leu Lys Gly Phe

130 135 140

He Phe Ser Ser He He Leu Ala Ala Val Leu Gly Asn Ala Leu Val 145 150 155 160

He He Ser Val Gin Arg Asn Arg Lys Leu Arg Val He Thr Asn Tyr

165 170 175

Phe Val Val Ser Leu Ala Met Ala Asp Met Leu Val Ala Leu Cys Ala

180 185 190

Met Thr Phe Asn Ala Ser Val Glu Leu Ser Gly Gly Lys Trp Met Phe

195 200 205

Gly Pro Phe Met Cys Asn Val Tyr Asn Ser Leu Asp Val Tyr Phe Ser

210 215 220

Thr Ala Ser He Leu His Leu Cys Cys He Ser Val Asp Arg Tyr Tyr 225 230 235 240

Ala He Val Arg Pro Leu Glu Tyr Pro Leu Asn Met Thr His Lys Thr

245 250 255

Val Cys Phe Met Leu Ala Asn Val Trp He Leu Pro Ala Leu He Ser

260 265 270

Phe Thr Pro He Phe Leu Gly Trp Tyr Thr Thr Glu Glu His Leu Arg

275 280 285

Glu He Ser Leu His Pro Asp Gin Cys Ser Phe Val Val Asn Lys Ala 290 295 300

246 Tyr Ala Leu He Ser Ser Ser Val Ser Phe Trp He Pro Gly He Val 305 310 315 320

Met Leu Val Met Tyr Trp Arg He Phe Lys Glu Ala He Arg Gin Arg

325 330 335

Lys Ala Leu Ser Arg Thr Ser Ser Asn He Leu Leu Asn Ser Val His

340 345 350

Met Gly His Thr Gin Gin Pro Thr Ser Leu Ser Tyr Leu His Pro Ser

355 360 365

Asp Cys Asp Leu Asn Ala Thr Ser Ala Arg Glu Glu Thr His Ser Ala

370 375 380

Leu Ser Asn Leu Glu Arg Pro Arg Gly He Thr Phe Ala Ala Val Pro 385 390 395 400

Ser Pro Leu Pro Lys Cys Pro Leu Cys Gly Ala Asp He Ser Ser Thr

405 410 415

Thr Gly Thr Thr Ala Asn Ala Thr Ala Thr Ala Asn Ala Asp Ser Thr

420 425 430

He Asp Thr Thr Val Thr Thr Ser Ser Lys Arg Ser He His Glu Gin

435 440 445

Thr Pro Asp Leu Gly Gin Arg Pro Ala Ser Ser Ser Ser Ser Thr Arg

450 455 460

Phe Trp His Lys Arg Thr Ala Ala Val Thr Ala Cys Trp Gin Gin Ser 465 470 475 480

Lys Asn Arg Lys Arg Arg Phe Lys Thr Gly Cys Ser His Cys Gly Ala

485 490 495

Thr Gly Gly Ser Val Arg Pro Ala Lys Gly Trp Lys Ala Glu His Lys

500 505 510

Ala Ala Arg Thr Leu Gly He He Met Gly Val Phe Leu Leu Cys Trp

515 520 525

Leu Pro Phe Phe Leu Trp Tyr Val He Thr Ser Leu Cys Gly Pro Ala

530 535 540

Cys Pro Cys Pro Asp Val Leu Val Val Val Leu Phe Trp He Gly Tyr 545 550 555 560

Phe Asn Ser Thr Leu Asn Pro Leu He Tyr Ala Tyr Phe Asn Arg Asp

565 570 575

Phe Arg Glu Ala Phe Arg Asn Thr Leu Glu Cys Val Leu Pro Cys Leu

580 585 590

Glu Lys Arg Asn Pro Tyr Asn Ala Tyr Tyr Val 595 600

<210> 190 <211> 6617 <212> DNA <213> Drosophila

<400> 190 gttccgttac ttggtctttg acttcttacc ccagaatatg attcttggca gcaggagaaa 60 ccagtacgac ttgttttggt cgtattatga gtgaaatatt accactcatg tcattttgaa 120 cgtctttaaa gctcacaccc ttatggaccc attataagaa tatggcgtgg caaaatttcc 180 catttttatc gaggctggaa aaacttttcc acacatgcaa tcatgtttcg tttcacttat 240 catggctaaa acctagcaaa tagaaaaagt ttttttttat ccacaaacat atctgtattg 300 agtgccagca atctgtattg ctttagctta agatgtttac tattaataga gccaagtggc 360 aaatgacata cggcttacag agaaaataat ttccaattca attacattta cgtacatata 420 ttccttccta caagcagaca ggattattga tctaaatata aataaatata taataattat 480 tttaataata taatattaaa atgtagatta acagaatata ttttttttgt atgaaagcct 540 ctagggtatt tgtgtgactt ttttctctct gcataagtga agatgtttac tattaataga 600 gccaagaggc aagagaaaag tggcagcaat caagtgcttt tatttcggga ctgcatgtta 660 aaggcgattt cctgatcgaa gactttggat acctgatgcc atccgtctga atgtgacgtc 720 agcctggctg gggattcaat ttaaattcat ccttgagtct aatgactttt aatgttgttt 780 gcttcacagg cgagtgcgca atttttgggc ctgtcgtcga ctgcttatcg gctatgtgcc 840

247 accgcagccg caaaggatac gacagacaat attaataacg cattgatacg agtgggcggc 900 cgatttgctt ttgtttttct ttcccaactt ggcggtggaa aggagtggtg tggcgtggcg 960 tggagtggat agagtccaca attaatcgac gacagctagt atgttgcaag gcgtcgccat 1020 caccatagcc aacgacagca acgatgatgg catcaatcaa tcattcatgg ctcatgtgtc 1080 gcccagtccc aatcagagtc cctccattgg agtgggcatc ggtatcgcct catccacaat 1140 ggcgaatccc agcgagagcc ccgagatgtt gctgctgaag aacgacaaat tcctaacaca 1200 tgtcgcccat ctgctgaaca taacgaccga gaatctttca aatctcctgg gttccacgaa 1260 cggcacaaat gcgagcacaa tggcagcgga ttcgccggtc gacgagtccc tgaccctgcg 1320 aacagccctc accgtttgtt atgcactcat ttttgtggcc ggcgtgctgg gtaatcttat 1380 cacctgcatt gttatatcgc gaaataactt tatgcacacg gccaccaatt tctatttgtt 1440 caacctggcg gtttccgact taatactgtt ggtctcaggt gagatggcat ttttgaggga 1500 caccattgcg tatgcgtaat gcggcaaata tcctgcaggc atcccccagg agctgtacaa 1560 cctttggtat ccggatatgt atcccttcac ggacgccatg tgcatcatgg gcagtgtgct 1620 ctcggaaatg gccgccaatg caacggttct caccatcaca gcattcactg tggagcgata 1680 tatagcaatc tgtcatccat tccggtgagt ttttaacatt taaacgttat atatatttta 1740 aatatttatt tacattatta aacaaatgta taatttcttc agtgttattg cctcgctctc 1800 attaacaaag tggatcatgc ataattagga cagagaatat gaatagataa attaaacttg 1860 ataagcgtca gtcggaaaca ttatgatatg aaacaacaaa agtacctcac aaattatggg 1920 cacaataatt attcataact aaacagtctg gctgtggaat gataaaacaa gttaggcttg 1980 acaaccaaat tcccatcgtt tttaaatata ccaaattcat tagctttcat ttatagacac 2040 taattaaagt caggtccata aatgaaccaa gttcattaca gactatgtaa ttaagttcca 2100 ataaatgcgt tgtaaagata gaaagttagt tagtcaatta attgcttagt accaacatat 2160 ttgcattttt ggaatggtac aacaaaactt ttccttatac aggtatcacc agttccttcc 2220 aaatgttctg accattttgc ggtcaaagaa tacaacagct tccttaagcg aaagcgtctg 2280 gttttcattt acgatgttgc atttccttta gttcagaaac tcttgaatag ctagaagaaa 2340 tgaaacttaa aaaccttaca ttgttgtttt caaacacaat ttccgtttct tagcattttt 2400 cacaaattaa ttgttacgaa tacaatcact tggagtatgt ccttaagaat atgcagacac 2460 aaaagggtgg ttttctataa gaagggattc caagtccgat tacaaagtta aggcaaaaaa 2520 ctttcatgtc tctgaagttg ggattaaata ttgttgtcga aaagagtaaa aggtttctat 2580 gtttgccatt taatagtatt atagttattt tgaaacgaaa ggatattcgg acatgtgctt 2640 agcatgaaaa aggtctgaaa cccattgcag tcactttacc aaaagaagtt aaaagtgatg 2700 tctattaaat ttggtatgaa actgtttgaa ttccttccca tttacaccca cattcaaagt 2760 aaatatttat gttgcactca atatcccaaa ccttaaagag aaagttaaaa agcgtaaaaa 2820 gtgtaggtgg tcactgcgtg tactttacaa ccgtaatatt ttccatctta tatctgccca 2880 cgtttatccg aaacatcgac atcatcttgt ccttaatact taacatataa tgtagcctaa 2940 tctttccgtc atttgtaggc agcacaccat gtcaaaattg tcgcgagcca ttaaatttat 3000 atttgccatt tggctggcgg ccttcctttt ggcccttccg caggccatgc aattttcggt 3060 ggtctaccag aacgaaggat actcgtgcac ggtgggtggg actgaaatgt gaaaaccaac 3120 tgacgcatca tcgagtgtcc ttttcgctgt ttattccctt agatggaaaa cgacttttac 3180 gcccatgtgt tcgccgtttc gggatttatt ttcttcggtg gacccatgac ggcgatttgt 3240 gtactgtacg tgctgatcgg agtgaaactg aagaggagtc gactgctgca atcgctgccg 3300 cgaaggactt tcgatgcgaa tcgcggccta aatgcccagg gacgagtcat cagaatgttg 3360 ggtaggtgag ttaagttggc ggcttgattg attaaagaca gcaatatgcc ccaccgccaa 3420 ccagaaacaa caagaacatc cacggctgtc aaaacttttt ccgccgaaag tcttaaattg 3480 aaaattactg tcaacgtatt tgcgttggcg aacatcaaac agggaattcg tcatagcccc 3540 gccctcattg ccttccgccc acttcatttg cacttgcgtc atgtgggctg aacgtgcttc 3600 tgtttttttc cctcttttcc ctcaacggtg tcgttaattt ttcgcaaaca tcggtgcgta 3660 tgtgtaaagc tcttaaatgg ccatctagcc tatgaagcaa aggtgaagcc aggtgtcacc 3720 tcaaaagtaa tcaagccggg gcacttaaat gaactcaaga ctgctgggtg cacacagcaa 3780 gcttaaatat ttgtaaaaag tgtttcttga atctatagac atatgtccgt taacgtgcca 3840 cgttataagc tgttaaattt taaaggaatt cagcacacat ctcgtgtatt attcacatat 3900 tttatttata taattagaaa ttcttatcaa accatacagt gaataaattt aagtgtaaat 3960 ccaggcccaa ttttagatcc caataagccg ttttttctta cagcctacga aacaacgttt 4020 aatttactgt tgcttttaac tgaaacaccg accattgatt tcgaaattta ccattggccc 4080 tggcctgcca aatggaaatt gatggaccaa ttcagattaa gcccagagcc ttaaccataa 4140 attaatttgg ccagcaagag tggaaaaaaa acacacccgt tctcagggct tagttattca 4200 tagatagtgg gatattattt atcgtttgct aagaggtaat accttggctt ttatcaaaat 4260 gtgatatttt accaaaggcc cgtttgcgca aactattcga tttcggggga tataaaagat 4320 taagaccact ttcagtgtga gagagcccct tttccggtga cctagttgtt caggggtctt 4380 aatacgttgc ttatccttac ttgaccgtat ttgcagtagc tgtagccgtc gccttcttcc 4440

248 tctgctgggc tccattccac gcccagcgac tgatggcagt ttacggactg aatctgatta 4500 atataggcat cagtcgggac gccttcaacg attacttccg gatacttgat tacacgtccg 4560 gggtgctcta ctttctctcc acctgcatca atccgctact gtacaacatc atgagccaca 4620 agttccgcga ggccttcaag gtaagcccat gggatcaacc cttctcagtt aaccacttca 4680 taatagtaat ctattattaa ttgggtcctt cgcatgtttg tgaggacggt cacaaatgca 4740 gatgctttta aagttaaatt taagctttaa ttattcaaaa ttgtttttcg taaattaatg 4800 aattggtaat ctatgtattt tttacacttt taagatcact ctgacgcgac agtttggtct 4860 ggccaggaac caccaccacc agcagagtca gcaccaccag cacaactaca gtgcccttct 4920 ccgccagaat ggatcaatgc gtctgcagcc ggccagttgc agtgtaaaca acaacgcgct 4980 ggagccatat ggatcctacc gagtggttca gtttcgttgc cgggatgcga accaccaatt 5040 gtccctgcag gacagcattc gcaccaccac cacaaccacg acgataaaca gcaacagcat 5100 ggcagccgga aatggagttg gtggtggtgc tggtggcggt ggcggtgggc ggcgtctgcg 5160 gaaacaggag ctctatgggc caggtccggg tacagcagtt ccccatcgaa tgctgcaggc 5220 ccaggtgtct caactctcgt cgctgggcga tgccaattca ctgctggagg cggaggtggt 5280 ggacagacac tacgcatccg ggcgagccaa aagagctctc ttggccacca aaagtggtgc 5340 cctgctggtg acaccacctc aaagtggtga cccatcggaa gtcagtcagc ccgccactcg 5400 tctcaagctg actagggtga taagtagaag ggatgaggtg gccaacacaa gcactccgcc 5460 cttttgtggg agccacagtt tgccggatcc ggagacttgt caatcggcat cggtggctgg 5520 tcgaagctcc cgtaagtttc cgtggcgaaa acgaaggcaa aaaacggagg atcccagcag 5580 cgagggcttg acctatggct cacccaaatc ccagtgattt cagctggctg gtagctagag 5640 ttatacttag ttaggcattg tttagttagc gcaataaact tttctatctg taaataagcc 5700 agaaaaagtc ctgcgatttg aatgcaaatt tcgggtgacc ataaaaaatt taacgaatgg 5760 gcatggtcca gacaatttat gagagtcata aagccgggat aatgaggcta cggcgtatcg 5820 tgacgaatac acgccccaca tcattttgca atggcaaccg catagcactc ataaattaag 5880 tgttaagcta ccagctaaat aatgtgaata aataaaaatt gttctcaata ttacagcaaa 5940 atccttttaa atgcgttttc ctttcacaat gcatgccagt tacattcaag ttcgcctgca 6000 ttccaagttg tccaggatca aagggaaaat caaaaaaaac agtttacatc tcaagttttg 6060 caggtgcagc gtttccaagc aatctgttcc taccttttgc gacatttttc ctgcagattg 6120 cctggcattc tgttgatttc ccacacaaaa actaaaagcg ctgaaaaaaa taaaagaagc 6180 ataaaataaa ataaagtgcc aataaattag cagtcttaat attttcagag cccctcagaa 6240 gcaaatctag gaaggaaaac atgacataaa ttttaaatgg attgctcatc aggatatcgt 6300 gttgcagtag atatatatat tttcgcagtg taagtcacga ctccacttgc acctggcaac 6360 aaagtttcag tttgcacctg gcccattgcc ggaggtccat tagtcaagag ggctttgtag 6420 gctaggaagt ccggattgaa acgaatgtgc agagagtggc acgaatgggc ttatcctgcg 6480 gtgaattggc acgtggagtg catggagagt ggtgtcggtg ccacaaaata aatcaactta 6540 aaagtagcat acaaatttaa ggacccgact gatgttatgt ccaaagggaa ttattaatgg 6600 ttctttaaag gcaggca 6617

<210> 191

<211> 1983

<212> DNA

<213> Drosophila

<400> 191 atgttgcaag gcgtcgccat caccatagcc aacgacagca acgatgatgg catcaatcaa 60 tcattcatgg ctcatgtgtc gcccagtccc aatcagagtc cctccattgg agtgggcatc 120 ggtatcgcct catccacaat ggcgaatccc agcgagagcc ccgagatgtt gctgctgaag 180 aacgacaaat tcctaacaca tgtcgcccat ctgctgaaca taacgaccga gaatctttca 240 aatctcctgg gttccacgaa cggcacaaat gcgagcacaa tggcagcgga ttcgccggtc 300 gacgagtccc tgaccctgcg aacagccctc accgtttgtt atgcactcat ttttgtggcc 360 ggcgtgctgg gtaatcttat cacctgcatt gttatatcgc gaaataactt tatgcacacg 420 gccaccaatt tctatttgtt caacctggcg gtttccgact taatactgtt ggtctcaggc 480 atcccccagg agctgtacaa cctttggtat ccggatatgt atcccttcac ggacgccatg 540 tgcatcatgg gcagtgtgct ctcggaaatg gccgccaatg caacggttct caccatcaca 600 gcattcactg tggagcgata tatagcaatc tgtcatccat tccggcagca caccatgtca 660 aaattgtcgc gagccattaa atttatattt gccatttggc tggcggcctt ccttttggcc 720 cttccgcagg ccatgcaatt ttcggtggtc taccagaacg aaggatactc gtgcacgatg 780 gaaaacgact tttacgccca tgtgttcgcc gtttcgggat ttattttctt cggtggaccc 840

249 atgacggcga tttgtgtact gtacgtgctg atcggagtga aactgaagag gagtcgactg 900 ctgcaatcgc tgccgcgaag gactttcgat gcgaatcgcg gcctaaatgc ccagggacga 960 gtcatcagaa tgttggtagc tgtagccgtc gccttcttcc tctgctgggc tccattccac 1020 gcccagcgac tgatggcagt ttacggactg aatctgatta atataggcat cagtcgggac 1080 gccttcaacg attacttccg gatacttgat tacacgtccg gggtgctcta ctttctctcc 1140 acctgcatca atccgctact gtacaacatc atgagccaca agttccgcga ggccttcaag 1200 atcactctga cgcgacagtt tggtctggcc aggaaccacc accaccagca gagtcagcac 1260 caccagcaca actacagtgc ccttctccgc cagaatggat caatgcgtct gcagccggcc 1320 agttgcagtg taaacaacaa cgcgctggag ccatatggat cctaccgagt ggttcagttt 1380 cgttgccggg atgcgaacca ccaattgtcc ctgcaggaca gcattcgcac caccaccaca 1440 accacgacga taaacagcaa cagcatggca gccggaaatg gagttggtgg tggtgctggt 1500 ggcggtggcg gtgggcggcg tctgcggaaa caggagctct atgggccagg tccgggtaca 1560 gcagttcccc atcgaatgct gcaggcccag gtgtctcaac tctcgtcgct gggcgatgcc 1620 aattcactgc tggaggcgga ggtggtggac agacactacg catccgggcg agccaaaaga 1680 gctctcttgg ccaccaaaag tggtgccctg ctggtgacac cacctcaaag tggtgaccca 1740 tcggaagtca gtcagcccgc cactcgtctc aagctgacta gggtgataag tagaagggat 1800 gaggtggcca acacaagcac tccgcccttt tgtgggagcc acagtttgcc ggatccggag 1860 acttgtcaat cggcatcggt ggctggtcga agctcccgta agtttccgtg gcgaaaacga 1920 aggcaaaaaa cggaggatcc cagcagcgag ggcttgacct atggctcacc caaatcccag 1980 tga 1983

<210> 192 <211> 660 <212> PRT <213> Drosophila

<400> 192

Met Leu Gin Gly Val Ala He Thr He Ala Asn Asp Ser Asn Asp Asp

1 5 10 15

Gly He Asn Gin Ser Phe Met Ala His Val Ser Pro Ser Pro Asn Gin

20 25 30

Ser Pro Ser He Gly Val Gly He Gly He Ala Ser Ser Thr Met Ala

35 40 45

Asn Pro Ser Glu Ser Pro Glu Met Leu Leu Leu Lys Asn Asp Lys Phe

50 55 60

Leu Thr His Val Ala His Leu Leu Asn He Thr Thr Glu Asn Leu Ser 65 70 75 80

Asn Leu Leu Gly Ser Thr Asn Gly Thr Asn Ala Ser Thr Met Ala Ala

85 90 95

Asp Ser Pro Val Asp Glu Ser Leu Thr Leu Arg Thr Ala Leu Thr Val

100 105 110

Cys Tyr Ala Leu He Phe Val Ala Gly Val Leu Gly Asn Leu He Thr

115 120 125

Cys He Val He Ser Arg Asn Asn Phe Met His Thr Ala Thr Asn Phe

130 135 140

Tyr Leu Phe Asn Leu Ala Val Ser Asp Leu He Leu Leu Val Ser Gly 145 150 155 160

He Pro Gin Glu Leu Tyr Asn Leu Trp Tyr Pro Asp Met Tyr Pro Phe

165 170 175

Thr Asp Ala Met Cys He Met Gly Ser Val Leu Ser Glu Met Ala Ala

180 185 190

Asn Ala Thr Val Leu Thr He Thr Ala Phe Thr Val Glu Arg Tyr He

195 200 205

Ala He Cys His Pro Phe Arg Gin His Thr Met Ser Lys Leu Ser Arg

210 215 220

Ala He Lys Phe He Phe Ala He Trp Leu Ala Ala Phe Leu Leu Ala 225 230 235 240

Leu Pro Gin Ala Met Gin Phe Ser Val Val Tyr Gin Asn Glu Gly Tyr

245 250 255

Ser Cys Thr Met Glu Asn Asp Phe Tyr Ala His Val Phe Ala Val Ser

250 260 265 270

Gly Phe He Phe Phe Gly Gly Pro Met Thr Ala He Cys Val Leu Tyr

275 280 285

Val Leu He Gly Val Lys Leu Lys Arg Ser Arg Leu Leu Gin Ser Leu

290 295 300

Pro Arg Arg Thr Phe Asp Ala Asn Arg Gly Leu Asn Ala Gin Gly Arg 305 310 315 320

Val He Arg Met Leu Val Ala Val Ala Val Ala Phe Phe Leu Cys Trp

325 330 335

Ala Pro Phe His Ala Gin Arg Leu Met Ala Val Tyr Gly Leu Asn Leu

340 345 350

He Asn He Gly He Ser Arg Asp Ala Phe Asn Asp Tyr Phe Arg He

355 360 365

Leu Asp Tyr Thr Ser Gly Val Leu Tyr Phe Leu Ser Thr Cys He Asn

370 375 380

Pro Leu Leu Tyr Asn He Met Ser His Lys Phe Arg Glu Ala Phe Lys 385 390 395 400

He Thr Leu Thr Arg Gin Phe Gly Leu Ala Arg Asn His His His Gin

405 410 415

Gin Ser Gin His His Gin His Asn Tyr Ser Ala Leu Leu Arg Gin Asn

420 425 430

Gly Ser Met Arg Leu Gin Pro Ala Ser Cys Ser Val Asn Asn Asn Ala

435 440 445

Leu Glu Pro Tyr Gly Ser Tyr Arg Val Val Gin Phe Arg Cys Arg Asp

450 455 460

Ala Asn His Gin Leu Ser Leu Gin Asp Ser He Arg Thr Thr Thr Thr 465 470 475 480

Thr Thr Thr He Asn Ser Asn Ser Met Ala Ala Gly Asn Gly Val Gly

485 490 495

Gly Gly Ala Gly Gly Gly Gly Gly Gly Arg Arg Leu Arg Lys Gin Glu

500 505 510

Leu Tyr Gly Pro Gly Pro Gly Thr Ala Val Pro His Arg Met Leu Gin

515 520 525

Ala Gin Val Ser Gin Leu Ser Ser Leu Gly Asp Ala Asn Ser Leu Leu

530 535 540

Glu Ala Glu Val Val Asp Arg His Tyr Ala Ser Gly Arg Ala Lys Arg 545 550 555 560

Ala Leu Leu Ala Thr Lys Ser Gly Ala Leu Leu Val Thr Pro Pro Gin

565 570 575

Ser Gly Asp Pro Ser Glu Val Ser Gin Pro Ala Thr Arg Leu Lys Leu

580 585 590

Thr Arg Val He Ser Arg Arg Asp Glu Val Ala Asn Thr Ser Thr Pro

595 600 605

Pro Phe Cys Gly Ser His Ser Leu Pro Asp Pro Glu Thr Cys Gin Ser

610 615 620

Ala Ser Val Ala Gly Arg Ser Ser Arg Lys Phe Pro Trp Arg Lys Arg 625 630 635 640

Arg Gin Lys Thr Glu Asp Pro Ser Ser Glu Gly Leu Thr Tyr Gly Ser

645 650 655

Pro Lys Ser Gin 660

<210> 193 <211> 4902 <212> DNA <213> Drosophila

<400> 193 ttgggcaaat taaggaaact ttttgtggtt tcagttactc gtttaagcca cattttccca 60

251 acatatgctg cactttatga attaaaagtc atttatttta ggctgcacac acgttatgtt 120 tgcctgacaa attgcatttg ctgaaattaa aacaaaatgc actgggacac tgcgttatgg 180 catgctgcta attagtcacc aacagcggct ttcagcgaat gttggccaat cgcgagaatg 240 gctttcatcc actgtctaga ctccagacca aaaagcgaat ttgtgcgcca gataaacatc 300 ttaatggcca gggattatga tgcagtgccc gctttttact gacagtaatt agccagacgc 360 ccattgaacc ctcttcttga taatccccac ttgatccaca ctctttcaaa aaaaaaaaat 420 gtattcatta aatgggaaaa aaatatttac tgcaagagaa atgttattaa tggatattga 480 aaaactgaca ttagataaca gtttctattg gactgctaac aaagtcggtc agctgtttaa 540 aaaactgaga tcgcttttat atttaaattg tataataaaa ccattagggt atcaacctta 600 atatgtattt atatatcact gtactccaaa tactatttac gcttaactat gtagattcat 660 tttattttta tcaaaagtcc attctttttt tattaaactc cactttataa atgaaacaac 720 ggtcgaattt ttgaactgag tacataacta catagtttat tcgattacgt gcactataac 780 tataattcga actatagctt tgggctatat tacggttatt ggtaaggaca accatataat 840 tgaccccaaa cgcggaatat ttgtctaaat taaaacacaa acaagctgga gtggcgcttg 900 ctgctcgtat cacagttgtg tgtgtgtgta atgtacgtag gtggcactgg aatggactac 960 ctcgcttatc gagtacagat agaggatatg ctgaccccct ttaaaaggcg gcccgctctt 1020 cagtgtcgcc tccattcacc gtcgccccct tttcgtgcgg tttgtggctg cctttgcgtc 1080 tggcacgcca attgaatttg gtcctgagac ccttgaacgg gcttgagctc ttgagcactt 1140 tcactttcgc cttgcgcact ttgccactcg actcgtcacc gctcacgccc cccgaccccg 1200 cggcccctgt tgtgctgcct cctgccacgc cccccgtcac acctcctggt gggcgggtga 1260 tgcgcgtaag tttaaggcgt gaccgcgaga tggccaagtc atctgtgagc tcgtcaatgg 1320 agcacatcgt gggctggcgc tgcagtggct ccccgggaaa ctgcaaatcc tcctccaaga 1380 gggaatgggc atcgcccacc gatgacagct gcgatatttg cgtctggagc atgcgacgcg 1440 gattatcgaa gaggtcttgc cggctgcgat tctgaccctg catctggaca ctgtccaagg 1500 acacgcggtt caggcgcacc gactgacccg ttgtcgttcc attgccactg ccattggcag 1560 agccatttag cccagtggtg gtcgtcgcca tggaagtcat tgtggtgcga acgctgtcct 1620 gcaggaggaa atcaaggaat ggagggataa tcagaaaggg aaagtgcagt cgccagacac 1680 gaaaataagt aacgcaataa acatcttata gtggttttaa aaagtctcgt gattcaaatt 1740 tcattttgag aaacaggaca tacactatat taatcctttt cattttcctc ttaaataatg 1800 ccacataata gaatttaagt gcatatatcg aatgataatt atgtaatttt tctcagtgca 1860 ctcaccgttg tgtgcagccg cagtgaaccc gtttgattac gtcgaagagc gctgtaagta 1920 tgaggaagcc cccttccctg atttttgcca ccaagtccaa agtgtctagc caaagttacc 1980 taaaatggga ttaaatacgt tttttaattc tagcttgaag tttaaaatca ctaaattgac 2040 cgttaaagaa tcgattaata aacttgtaac ctgaagctta ttttcaattt cctaacgcaa 2100 gctatagaaa tgaatatccg gcagcgaaac tcaccttaaa agcctcacga aacttgtggc 2160 tcatgatgtt gtagagcagc gggttgatgc aagttgagag gaagtagaga acaccggacg 2220 tatagtcgag gatgctgaac acgtcgttga accactggga ctcaatgccc gaggtggatc 2280 catagaccgc catcagccgc tgggcgtgaa agggggccca gcagatgaag aaggccacgg 2340 ccaccgccac tgggaaagtt ggataagggc gcctgatgca accatgagtt atttcggata 2400 tttcatatcc tgcttaccca gcatccggat gactcgcgtt tgggcgctta tcccccggtt 2460 tacatcgtaa catcgcctgg gaagcgcctg caggagtcgg ctccgtttca acttcacccc 2520 gatgaggaca tagagcacgc agatggccgt catgggtccg ccaaagaaca ggaagcccga 2580 cacagcaaac acatgggcaa aaaagtcgtt tttcatctac agcaggcatt tcacaaaaat 2640 aatatatatg tgtattcgca tgcgatacga tatggttttg gcttacagcc acagccggaa 2700 ggcaatggct gtaaatttga ttgcctaaac tgagtcgaac ctcgtaaggg attgtcgctg 2760 tttttatcat gctcttaaat tttttgtaat tcacaaaggc tctctattcg aactttctat 2820 acggaaaaca cataatgaat caaaggatca aaggaccggt tctacgaatc aattaaccag 2880 gtaactcata actgggggac atacgattaa gggtctcgca tcaatcatac gcaccgtgca 2940 cgatgttccc atgccctgca tcaccacgga gaactgaatg gcttggggca gggccagcaa 3000 aagggcagct atccagatgg caaatatgaa ctttacggcc cgtgacaact tggacatcgt 3060 gtgctgcctg tatcgaaagc agaaccaatt aagcaagttt ggggcaaaat ggaaatgggc 3120 agtggaagga atgaaggttc ccttacctga acggatgaca aatggcaata tatcgttcga 3180 ctgtgaacgc ggtaatggtt agaactgtcg cattggccgc cgtttccgag agaacgctct 3240 ccaatatgca gatgctgtca ctgaaaggat aattatccgg gtgccagagg ttatagaggt 3300 cctgcggcat tcctaagaac ataaatagca aaatagcaaa atatatagtg tgattataaa 3360 tatttaataa tagctgaaat tatagcctat agcctcaaaa tgcaaatcga tttgagcatc 3420 tgccgaatat ctcactctac attttcttgt ttatttacaa attttaattt aatatgcctc 3480 agttccattt attgtttgca ctactgaact gaattaaatt ataattcaaa aaccatgaac 3540 attttagttt tgcactcacc tgagcataac aaaatcatgt cggatatagc gaggttaaac 3600 agataaaagt tggtggccgt gtgcataaag ttgttccgcg aaatgacaat gcatgtgatg 3660

252 aggttgccca aaacgccggc gataaatatg agggcgtagc ccacgcttag ggtggccagc 3720 agtgaaagtg gtgtcatcgg ggtcaccgtg ggcaaaagct cctccggctc caggccctgg 3780 agaaggctgg tcaggttgtc cgcggagatg ttcagcactt gtgtcagatt taagagaaat 3840 ttctcattgt gaaacagttg tagatcggtt gccaggacac cggaactgtt agtgggcagc 3900 attttgactg ccatagggtg tgtgtctttg tgtgtgtgta tacgcactat tattttcgaa 3960 tttctttgga aatttcagac ttctgcgtat gtattctcaa tcgaagcttt cgcttgcaaa 4020 taatgttttc ataacgcccc ttacgggggc tcatcaattt cgacttaggc cagagccact 4080 ccacttgcaa tctgttgtca tgagtgtggg attaaattat gtgtacggat gtgtgtgata 4140 aggtggaccc tatgtgctat ttaaataaaa ctatgttttt caaaatttgt taaaatttaa 4200 ataaaataat acaagacaaa taacgcattt taacgaattt agtaataaaa caaattcaaa 4260 cattaaggct ttttactcca gatttctaaa ttaccataaa ttatacatat acacaatttg 4320 gttggtaagc tgtgcgcttt gtttagcttg ctaaggtcca ccttagagag cccgtcttaa 4380 agcgtgtttg tgtcctgtgt gtttacctgg catcctggga aactggcagg cggcagtcag 4440 gcgtgtccta ggcgaaagac caggatcagg gcgagtggaa gctgaaaatt aatttgaatt 4500 gctaagtggc atttagtcaa aatatttgtg tacactggat gaatttaagg atgttgctac 4560 aaggctgaga aggacaggcc tgccgatccg tctcccaccc aacaccaggt ggcaaacgaa 4620 tgaaacgagc cagaagctca aggtcaggtg gtggataaga cggataagga gacgacgatg 4680 gcaaatggac accgggtgac ttaataacat taacatagtt tcattccatt cagatgatga 4740 gtgttttcgg ctgctgctgt tctgctctgt tctgttcaca ttctggctat acttttcgtt 4800 attgttgctg ctgaccgctg ttgaccgttt ttggacgttt tcattatcat tatcataaaa 4860 aagtttctac aatatatgca caaccaaaag aatgctgtcg aa 4902

<210> 194 <211> 1788 <212> DNA <213> Drosophila

<400> 194 atgctgccca ctaacagttc cggtgtcctg gcaaccgatc tacaactgtt tcacaatgag 60 aaatttctct taaatctgac acaagtgctg aacatctccg cggacaacct gaccagcctt 120 ctccagggcc tggagccgga ggagcttttg cccacggtga ccccgatgac accactttca 180 ctgctggcca ccctaagcgt gggctacgcc ctcatattta tcgccggcgt tttgggcaac 240 ctcatcacat gcattgtcat ttcgcggaac aactttatgc acacggccac caacttttat 300 ctgtttaacc tcgctatatc cgacatgatt ttgttatgct caggaatgcc gcaggacctc 360 tataacctct ggcacccgga taattatcct ttcagtgaca gcatctgcat attggagagc 420 gttctctcgg aaacggcggc caatgcgaca gttctaacca ttaccgcgtt cacagtcgaa 480 cgatatattg ccatttgtca tccgttcagg cagcacacga tgtccaagtt gtcacgggcc 540 gtaaagttca tatttgccat ctggatagct gcccttttgc tggccctgcc ccaagccatt 600 cagttctccg tggtgatgca gggcatggga acatcgtgca cgatgaaaaa cgactttttt 660 gcccatgtgt ttgctgtgtc gggcttcctg ttctttggcg gacccatgac ggccatctgc 720 gtgctctatg tcctcatcgg ggtgaagttg aaacggagcc gactcctgca ggcgcttccc 780 aggcgatgtt acgatgtaaa ccgggggata agcgcccaaa cgcgagtcat ccggatgctg 840 gtggcggtgg ccgtggcctt cttcatctgc tgggccccct ttcacgccca gcggctgatg 900 gcggtctatg gatccacctc gggcattgag tcccagtggt tcaacgacgt gttcagcatc 960 ctcgactata cgtccggtgt tctctacttc ctctcaactt gcatcaaccc gctgctctac 1020 aacatcatga gccacaagtt tcgtgaggct tttaaggtaa ctttggctag acactttgga 1080 cttggtggca aaaatcaggg aagggggctt cctcatactt acagcgctct tcgacgtaat 1140 caaacgggtt cactgcggct gcacacaacg gacagcgttc gcaccacaat gacttccatg 1200 gcgacgacca ccactgggct aaatggctct gccaatggca gtggcaatgg aacgacaacg 1260 ggtcagtcgg tgcgcctgaa ccgcgtgtcc ttggacagtg tccagatgca gggtcagaat 1320 cgcagccggc aagacctctt cgataatccg cgtcgcatgc tccagacgca aatatcgcag 1380 ctgtcatcgg tgggcgatgc ccattccctc ttggaggagg atttgcagtt tcccggggag 1440 ccactgcagc gccagcccac gatgtgctcc attgacgagc tcacagatga cttggccatc 1500 tcgcggtcac gccttaaact tacgcgcatc acccgcccac caggaggtgt gacggggggc 1560 gtggcaggag gcagcacaac aggggccgcg gggtcggggg gcgtgagcgg tgacgagtcg 1620 agtggcaaag tgcgcaaggc gaaagtgaaa gtgctcaaga gctcaagccc gttcaagggt 1680 ctcaggacca aattcaattg gcgtgccaga cgcaaaggca gccacaaacc gcacgaaaag 1740 ggggcgacgg tgaatggagg cgacactgaa gagcgggccg ccttttaa 1788

<210> 195

253 <211> 595 <212> PRT <213> Drosophila

<400> 195

Met Leu Pro Thr Asn Ser Ser Gly Val Leu Ala Thr Asp Leu Gin Leu

1 5 10 15

Phe His Asn Glu Lys Phe Leu Leu Asn Leu Thr Gin Val Leu Asn He

20 25 30

Ser Ala Asp Asn Leu Thr Ser Leu Leu Gin Gly Leu Glu Pro Glu Glu

35 40 45

Leu Leu Pro Thr Val Thr Pro Met Thr Pro Leu Ser Leu Leu Ala Thr

50 55 60

Leu Ser Val Gly Tyr Ala Leu He Phe He Ala Gly Val Leu Gly Asn 65 70 75 80

Leu He Thr Cys He Val He Ser Arg Asn Asn Phe Met His Thr Ala

85 90 95

Thr Asn Phe Tyr Leu Phe Asn Leu Ala He Ser Asp Met He Leu Leu

100 105 110

Cys Ser Gly Met Pro Gin Asp Leu Tyr Asn Leu Trp His Pro Asp Asn

115 120 125

Tyr Pro Phe Ser Asp Ser He Cys He Leu Glu Ser Val Leu Ser Glu

130 135 140

Thr Ala Ala Asn Ala Thr Val Leu Thr He Thr Ala Phe Thr Val Glu 145 150 155 160

Arg Tyr He Ala He Cys His Pro Phe Arg Gin His Thr Met Ser Lys

165 170 175

Leu Ser Arg Ala Val Lys Phe He Phe Ala He Trp He Ala Ala Leu

180 185 190

Leu Leu Ala Leu Pro Gin Ala He Gin Phe Ser Val Val Met Gin Gly

195 200 205

Met Gly Thr Ser Cys Thr Met Lys Asn Asp Phe Phe Ala His Val Phe

210 215 220

Ala Val Ser Gly Phe Leu Phe Phe Gly Gly Pro Met Thr Ala He Cys 225 230 235 240

Val Leu Tyr Val Leu He Gly Val Lys Leu Lys Arg Ser Arg Leu Leu

245 250 255

Gin Ala Leu Pro Arg Arg Cys Tyr Asp Val Asn Arg Gly He Ser Ala

260 265 270

Gin Thr Arg Val He Arg Met Leu Val Ala Val Ala Val Ala Phe Phe

275 280 285

He Cys Trp Ala Pro Phe His Ala Gin Arg Leu Met Ala Val Tyr Gly

290 295 300

Ser Thr Ser Gly He Glu Ser Gin Trp Phe Asn Asp Val Phe Ser He 305 310 315 320

Leu Asp Tyr Thr Ser Gly Val Leu Tyr Phe Leu Ser Thr Cys He Asn

325 330 335

Pro Leu Leu Tyr Asn He Met Ser His Lys Phe Arg Glu Ala Phe Lys

340 345 350

Val Thr Leu Ala Arg His Phe Gly Leu Gly Gly Lys Asn Gin Gly Arg

355 360 365

Gly Leu Pro His Thr Tyr Ser Ala Leu Arg Arg Asn Gin Thr Gly Ser

370 375 380

Leu Arg Leu His Thr Thr Asp Ser Val Arg Thr Thr Met Thr Ser Met 385 390 395 400

Ala Thr Thr Thr Thr Gly Leu Asn Gly Ser Ala Asn Gly Ser Gly Asn

405 410 415

Gly Thr Thr Thr Gly Gin Ser Val Arg Leu Asn Arg Val Ser Leu Asp

420 425 430

Ser Val Gin Met Gin Gly Gin Asn Arg Ser Arg Gin Asp Leu Phe Asp

254 435 440 445

Asn Pro Arg Arg Met Leu Gin Thr Gin He Ser Gin Leu Ser Ser Val 450 455 460

Gly Asp Ala His Ser Leu Leu Glu Glu Asp Leu Gin Phe Pro Gly Glu

465 470 475 480

Pro Leu Gin Arg Gin Pro Thr Met Cys Ser He Asp Glu Leu Thr Asp 485 490 495

Asp Leu Ala He Ser Arg Ser Arg Leu Lys Leu Thr Arg He Thr Arg 500 505 510

Pro Pro Gly Gly Val Thr Gly Gly Val Ala Gly Gly Ser Thr Thr Gly 515 520 525

Ala Ala Gly Ser Gly Gly Val Ser Gly Asp Glu Ser Ser Gly Lys Val 530 535 540

Arg Lys Ala Lys Val Lys Val Leu Lys Ser Ser Ser Pro Phe Lys Gly

545 550 555 560

Leu Arg Thr Lys Phe Asn Trp Arg Ala Arg Arg Lys Gly Ser His Lys 565 570 575

Pro His Glu Lys Gly Ala Thr Val Asn Gly Gly Asp Thr Glu Glu Arg 580 585 590

Ala Ala Phe 595

<210> 196 <211> 9889 <212> DNA <213> Drosophila

<400> 196 taattgctgc cgggtaattg caactgagct caggtcagcg agtttgctaa ccatggcgtc 60 attatactgt tgcactataa aatcattcga cccaagtccg attaacttaa gtgggtctta 120 gaccaaaaga tgtgtatttc gaatacttct caaacgttat ttccttaagt caaatcattt 180 caagaactgg gagagcaaat aaatatgcga tttcctcgac ttatagttac ttgtgtgaaa 240 tttgcgcgct tgtgcaaatt cgaatgtttg caacttaatt ggactgcata atagattggg 300 caaaaggatt ttataacaat tccagtgtcc agcccatcgt actgatgtgg ctaattgttt 360 tgctgacttg cacctaggca aagcaatttc ccttgaaaac aatcaaattc aaaacaatca 420 agtaaacaag acagctgagt gaaagacttt ggcttcatgg gtgaacatat ttgtcggttg 480 aaggttgagt ttttgtttaa gatgattgca catggcacac aggttgattt taatctaaat 540 ttaatttgag catttgagca tttttctgct gaaccgggaa aacccacatt tgcttaccta 600 gaaaaaccgg ttttcagaga aagttgcgag taatacatat ttaatacgat ttcaagtcct 660 gtgtgtacaa cgttttatct aagaaaacca gaaaaccaga agctttttag cttagacagc 720 tttaatattt aattacagtg ttcacaaaaa aaaaaaacga aattcccctt ttctttgctt 780 caaatttaat tagacatgta tctattgttt ttttttttcc acttgcagct tatttatcca 840 acctaagcca actaaatgat gcaatgctgg tgacatataa aacgaaagtg gaaacggagt 900 tcattcctta agtaaccaat ttaagatgtt gtgctcccaa gatccctaaa ccaccgtcca 960 aacccttcga ataacttatt taagccaaga tatagacaaa atggaggacg agtggggctc 1020 ctttgatcgt ctgcccagtg ttccgagtgc ctcgatggat ttggagacgg aaaacgaggt 1080 ggtcagcaat tggtccacac tggccaactt cacgcgactt gtggctggtg ccgctcctga 1140 aatcgtcaac tatacgctca acatgatcga cgtgggtgtg ggcatggcca cggatatatc 1200 caatttgagc gtgagcacca cgcccctgcc cgcctacgca atctccaata gctcctcact 1260 ggcgcacacc aatagtcgcc atgaagcacc accgatggcg gaacaggttc cggagcacgt 1320 gatggatcac gcacctcaac tatcccgatc cgggttgctg aaagtgtatg tcctggcggt 1380 aatggcactg ttctctctgc tgggcaacct gctgaccatc tggaatatct acaaaacccg 1440 catctcaaga agaaactcac ggcacacgtg gagtgctatc tactcactga tgttccatct 1500 gtccatcgcc gatgtcctgg tcacctggtt ctgcattatc ggggaggccg cgtggtgcta 1560 caccgtccag tggctggcca atgagctcac ctgcaagctg gtgaagctct tccagatgtt 1620 tagcctctac ctgagcacct atgtcctggt cctcatcgga gtggaccgct ggatagcggt 1680 caagtatccg atgaagtcgc tcaacatggc caagaggtgt cataggctac ttggcggtac 1740 ttacatcctg tcgctggtgc tcagcttgcc acaggtaagt tttgatacac tgaaaataag 1800 acctttaaag ttcttataaa atcatttgcc tagaacaaac agataagata gttacacaaa 1860

255 taagcaagat tgtaataata taaaagtcat ttttggccta taaatggtct aaaaatattt 1920 gtgggatatg ttagattcaa tctttagata atttaaatga aaaaaagtta aaggtgccct 1980 ttgattagga aatcagtaaa agctttaaga tctcctctta atttatgtac cctttcggaa 2040 aatttctgtt cgacgtaaat gcaaaaagcc ttgagggtac ccgtaaaaac attattctat 2100 ttaaaaagat ttagccaaag ggcaaattta aagcgtctgc atctgaaaaa atggcccttc 2160 cagtgaagtg cgaagaagac acgcttatga aaataatcca gtcacttttg gtggggcgtt 2220 ccattacgct aagttaaagc tgcgacttag ccgtggtaat attcacctgc cactgcccct 2280 gcctgtgccc cctactcctg gcactccatt tgatccttac gctcgcgctg atgaagttga 2340 aataatatgt ttactttata acacgtatac gccccgtggc acagtgcaaa tagtcttgag 2400 taggcgccag aatgtgtgca gacattaaaa atgattgcct ttcgcacaat aagtgtacac 2460 taaatgtggc tttaggccgc tgccacgccc acacacacgc gtgctgatgg gcgtaggaat 2520 gggcataggg ttgggcgtat ggggacaccc aatcgaattc cggtcgtccg accgacaaag 2580 ggtttttttc ttctggtttt tcctctcggc ttttcgcttg gggacgggcg accaaataaa 2640 aaaaaaaaaa ggtccgaaca agtgtgtctt ctgcctgacg acagacatta ttcatattcc 2700 cgatttcggt tctttgtgcg cagataggca cactgggtga tatattcctt tgccctggca 2760 gtcagctggc ggataagcct gaatgggact gcattaatgg gcgtcactcg ctttgttcta 2820 caactctaga acgactcggc ttcagatttc cggcaccctg attgtataat atatgccgcg 2880 tgtctccaca tcccgatttc atactcgatt cgcctggcct ttccttgatt tatggccccg 2940 ggtgaggcac ttcacttctc gaattcagtt aatctttagc tggagtgcta cgagctcctg 3000 ctcgtgtttt tccttaaagt ggaaattcgt ggacacttca gtttagggtg tcactaaggt 3060 aggtaattag cacgaaatct cacttcaaag ttgccaaggg ttagtaatat agttagattg 3120 aaaagtgact gcaaactttc cactgctctt tatgtgaccc gggtcataaa tatcgttcgc 3180 agaatttggt tagccataag tggggacaag tgggtagaaa ggtcaaacct tctgtataaa 3240 aagatttgtc acctgagaga tgccaaaaat agatgaaaaa gaaccaaagg gaaatttcct 3300 cctaagtgga tggtaagtgg atttcccgca cgcaagttat gcaactagca cactttcccc 3360 actgctcgcc cgcaaatgta tgctaaaatg tagctcattt aattagggag cccagcaacc 3420 cgacgccatt tccttttatc tgaataatgt attgcgtgga acaataatta cagacgtacc 3480 gtacaaaaat cgaggcgaga ttatatttgc tcactttggg gcaaaatgtg tgtgtggttt 3540 ttctgggtgc gaaggcatgc gcgagtcagt ttgttaaatc atctgacttg tttaaatgcc 3600 gcaaaaaatc tactgagctt aataacattt tgatgttttt ttccaatcga tgtcaagcgg 3660 aaaatttggc cgttttgttg ctgggaattt gggccgactt ttggtccagc cgacccataa 3720 tggaaaggac ataatgtatt ggttttggat ttttaaaata gaaccagact ttgatgaact 3780 gtccagcttg ggtgtaaata tttgatgacg aacgtcacaa attacgatga tatgacagaa 3840 gtcatttatg gatggccact gacacccaat taaaagaaac tttgcaatca ttaagccaat 3900 ttttatggtc cacttttcga catctcgctg agatcccggg aaactttctt catttcgctt 3960 ctactcgaat atgcgacata aaatttatgc cgcttacaga cgtgacggtc gaaacgttcc 4020 cgccggaaac gtaggaatca tctcaaacaa ttttccggat aactttttcc atgtcacacg 4080 ttcatggtgc aggcaaccaa acagccaacc aaccaaccaa gtggcacatg tattggtaag 4140 gagccacatc gaatccaata tgagacgcgc cgctgaactc gtcggtttca aataaaggag 4200 cgaaatgaaa attcacttcg actgccaata aacaacaaat gttttcaaca gcagcattta 4260 tttggctcca cttctatcga ccccaactcc tccgcgtcct tcgaacccaa ggaaaaaaga 4320 aaaaaagttt agtaccacac gcacacaacc acacagaaga atcctgccac aataactcga 4380 agtgtgagcc caaaaatgtg gcacaatgaa aacaggccgc cataatacag tcaaacacaa 4440 agttatccac aggtcctccg cagagtatta ttgcgaattg aatttcaccc acatatcatc 4500 aaattcagca gccttaggtg gcataattaa aatttcgtag aattgtttac aaattggagg 4560 gaactagtca atattacaag agtcccttgg cgatttcacc ttcagtgtgc gcgggctttt 4620 gataatcgat aggggtcctt aaatgcttag ctttaagtga attaaaattt gaatttagtt 4680 tcagaatatt tacagcagaa tttgaatcaa taattgcaat ttatatgtgc aagcattggc 4740 gaataaagta aataaccgga tttaattatt aggtgacaaa atcgtaacat ttaaatatat 4800 ttacctgaat aacaattgga aataagtgca aaaacagcaa aaagtataat aaagtttaga 4860 taaaaaatga aatccattta atattttaat ttgggctcat ctggattcat attttaggtg 4920 acaaaattaa ttattataat tattaaaaca aatgagcagg taacaagtca gtaagctcta 4980 acaatccttg ttaaatctaa cttaaacgta gctgagtgtc caatttaaat ggtcaattta 5040 atcgtgcctt taagccaaac aaatatgtat attttaacaa tctgatagtt ttacaaacgt 5100 cttaaacgat tgccaagcac ctgaccgatg tgtgaaaact acgaacttga gcaatacaat 5160 ttggttagaa cggaagttct tgaagttgtt ccctcacaat gaatcaatct tgttttattt 5220 tactgtcgca agtttttgtc taaagttttt cgttgcaact tgtctaactt tgccgcaaat 5280 agtgctgaag gcttgcttgt gtgtggcatg gttttagcgt ggagcgccct ttaaactttt 5340 cgagcatttt taatgaatgg caacatggaa ataatgaaca aacacttgaa aagttgaaat 5400 aatttaagaa agaatattga aagccacaat tatccttgct ttcttttact agtcatgacc 5460

256 tataaaaata tatttttcta ctataaaaag ccactggcac tttacttcgg tttcggcgga 5520 aggcaatggc ttggaagtta taggcgaaat taataaaaat caaccattag acgattatcc 5580 gcttctcgtt atttctgcgc ggggggtttt tgtgtagttt ttactacgcc actcggcgga 5640 gcgcggaaag ttttcccatt tcctccattt gggtcagctg ttgacacagc ggccgccaga 5700 aaacccataa aaagcgcaaa taaaaatact tttagcgtat tagttatgcg tagacacatc 5760 catcgttggt gtatttaaga tgctacactt cctttatcag ttatggccac acattttcct 5820 gctcgaaaag ctttttcatg gtacgagaat ttccaccttt ctacgtggca ctctgctaaa 5880 ctcggtaaga cttgaacaat ggagcagtag caactgcaga atgtatacat tttccaaaaa 5940 tgttccatca atttggaaat gatttcagcc aaacaagaaa atcaagcaaa agcacttttc 6000 acccataacc aagccgcttg ccacccacaa tggaaagtag atcaaagcca caacgttttg 6060 agtcagcagt ttgttaccat ggaccgcatg tgggtatttc catgtaaaca tgcctgtact 6120 tagtccttgg tgcaatcagg acatggatgg tttgctaata aaaatcttat tacggcacca 6180 tcttatttac acaacacggt agagatatat ggttttaaaa atttccattt tcctgcttaa 6240 aacaggcaat aaattgatag gaaggtaaat atccttaaga aacacttgta taaagttcaa 6300 gttcaatcca tgtgtcttaa cctttaattg tttactatgt tgcatgttcg ttccagttct 6360 tcatcttcca tgtagcgcgt ggcccattcg tggaggagtt ttaccagtgc gtcacccacg 6420 gattctacac ggcggattgg caggagcaga tgtacgccac cttcacgctg gtcttcacct 6480 tcctgctgcc gctgtgcatc ctgtttggca cctacatgtc caccttccgc accatttcca 6540 gtgagttttc agcgagaagg agtttacatt cccgtactaa cctgataacc tgataatcgt 6600 gcaggcagcg aaaagatgtt ccagggatca aagttggcca actactcaac ggccaaattg 6660 cccacacaga cgaatcgcca gaggctgata cacaaggcca agatgaagtc gcttcgcata 6720 tccgtggtga tcatcatagc gtttctcatc tgctggacgc cctactacgt catgatgatt 6780 atgttcatgt tcctcaatcc ggacaaaagg gtgagtttcc gcccgttccc ctgccgaatt 6840 tgaagctgaa tgacaagcag atatcgattc ctgataccaa aaggctcatc aatcagcagt 6900 cgatttgtca gtttgtagcg cacggtttgg gcgaatcctt tgtcctgttc cctaccatat 6960 ttacgacttg gggtcatggt tgtacgagta aaataaaaac gagaatacga cacgacctag 7020 tcgcagctgg caaatccgtt tggagctata cccactgcca taaaaatgat ttcttatgct 7080 caatttttaa ttaatcgtta cgccacccga ccgaccacac ggtcgcaatt tttccttaac 7140 ggcgtaccca actttgatga cttgccagag atggtccgta aaagctggcc caagttgcaa 7200 gattacggcg aggcaatccg ggcagaagga acacaaggtc gaattgctac aaaccgagca 7260 ttctgtacag taggggaaaa tgaatgagta gcaaaatatt tccaaagttt atttgtttcg 7320 atttaaattt taaaaatgct ataattgaca aaatagaatc atttttgctg tcactatttt 7380 taagtgaatg ggatatttgt ccgccgatta acctgaattt catatcctaa tgaattggat 7440 tgcacattca taatggcatt tccgctgaaa ctctttctcg ctgtggaaat cccagcgatg 7500 gcagtgtgca aaataattaa tttggaagcc aaatttttag cgcagtgtat ccataagcga 7560 cctgagcccc aattcgaccg caggaacgcc cacaatgcgc ccacgcgaat gtagagggga 7620 aaaggtgaaa ggtgtgcgac aagggcaagg aaattaattt gaatttcacg gattgcttgc 7680 agctgggcga cgatctgcag gacgccatct tcttcttcgg catgtcaaac agcctggtca 7740 acccactcat ctacggtgcc ttccacctgt gtcctggcaa agggggcaag tcgagcggcg 7800 ggggcggcaa caacaacgcc tacagcttga acaggtgagt ggtgagccaa cagaataagt 7860 taattctatt aaccaccaca tttcgtactt gtttttgcgc ttttatcgtg tcaaaaaata 7920 gttacttttc actcaagcaa tacactttta agacagccaa gcaagctttt gaagtctgaa 7980 ttgctgcttt tctgatcaaa gagtttttat tcttggtaat atttcacatt taagagtata 8040 aatgatagtg taaatttaaa taaaatagta gaaagttttc cctaaagatc gatgtataac 8100 tattaataca tattttactt aatctagtgt tgctttttaa tgacagtttt tgctgtgctt 8160 aaatttttac aaaataaatc ttaaatcctt gcaaagagtt ttcttttatg caaatggaaa 8220 acattgtttc atcgcttgtt aatatcattt actttattta tttattattc taaacagctg 8280 ccaaagcagc gaactatctc aggatcagat atgatttgct atgattttgt cacacttcct 8340 atgtttgttt tgataacgca aaaagcacac acaccgtgat tggcaataaa ctgataaatt 8400 cttttccgtc tggtttttat cacctcaccg catcgtccat tcccccgtcc actttccatc 8460 cgcaggggcg actcgcagcg cactccatcc atgctaacgg cggtgacgca ggtggacggc 8520 acaggtggca gttcccgcca gatgcgggcc ttccgccagc agagctacta ccgcagctcc 8580 tccaacggca cagccggacc gggtgcagct ccctttaagg agcaggttgg cctgctgcac 8640 gtgggtcccg gcaatgggac gcccggtggc tccgtctcta gcggcgccac gccgcagttg 8700 atccgtaagg gatcggctct gttggcccga caacccagct gtctgaggga gcaggagcac 8760 cagcagcgtt tgctgctgca cgagaagccc tcgaccctgg tgctcagcta cgacagccag 8820 cggggcggag tgggcgtggg cgtggccagc ggtctgctgg acaacaacga gcgagtgtcg 8880 agcgtgtgag agcagctggc gatggcggta gcggcggcgg cggtggcggt ggatgcaccg 8940 gacacagtag aagcagcagc agcaacagca tcagccgatg cggatgcgaa tgtggcgatg 9000 gaggacgcct gctcctgctg ccattgcctg agcagggagc tggtgcggcg gcagttggag 9060

257 ctccaagtgc ttccagtgca gtgaggcgac tgccagtgga tttgatccgg ctggctgagt 9120 ggccggagct ggggattcca gcgattccct cggtcaacgt ggggagtggc gtcgatgatt 9180 agatcaccgg ggcgtgcaac atgtgcttag atagtgctaa tcgagagtta agtcttcaaa 9240 cacaatgggt gtgcttagaa gtagcgtagg attagagcta gtccgtacga agtggttgcc 9300 ctacactggg agaaactcgt ggtcactttg catgttctct gaatgttcta ctaatacttg 9360 acttcaacaa ggatacaaat ataagagata atatctatgt acatcccata aaaccataaa 9420 aaattgcaat taaatctggt tgtgaaaaaa atagatttaa cttctgaatg tttcaaatgt 9480 tgccaattcg ccagcgtgta atccgatata agcaacaata attacaatta taatcaatgt 9540 gcaatcagag tcagttacaa tttacaatta tatgactgaa taattggact atgaatatat 9600 acgacttcaa atgagtttct ctcattagca gggcaacttt gtaatgttaa ttaacagcgt 9660 ttttcagttt ttcattttgt tcccccagcc gagtaactca aaaatcgatt ctataattgt 9720 gtaaaataga aatcatctaa aaacagggta aatctaacta ttgtaaatac atttactcat 9780 tattttgaga agaatattgt aaaaaaaaaa gattgtaaag tttaaaataa atatgagttc 9840 atgttcaacg acacaaggaa ttattttgat taatttaaag tactaaaaa 9889

<210> 197 <211> 1644 <212> DNA <213> Drosophila

<400> 197 atggaggacg agtggggctc ctttgatcgt ctgcccagtg ttccgagtgc ctcgatggat 60 ttggagacgg aaaacgaggt ggtcagcaat tggtccacac tggccaactt cacgcgactt 120 gtggctggtg ccgctcctga aatcgtcaac tatacgctca acatgatcga cgtgggtgtg 180 ggcatggcca cggatatatc caatttgagc gttccggagc acgtgatgga tcacgcacct 240 caactatccc gatccgggtt gctgaaagtg tatgtcctgg cggtaatggc actgttctct 300 ctgctgggca acctgctgac catctggaat atctacaaaa cccgcatctc aagaagaaac 360 tcacggcaca cgtggagtgc tatctactca ctgatgttcc atctgtccat cgccgatgtc 420 ctggtcacct ggttctgcat tatcggggag gccgcgtggt gctacaccgt ccagtggctg 480 gccaatgagc tcacctgcaa gctggtgaag ctcttccaga tgtttagcct ctacctgagc 540 acctatgtcc tggtcctcat cggagtggac cgctggatag cggtcaagta tccgatgaag 600 tcgctcaaca tggccaagag gtgtcatagg ctacttggcg gtacttacat cctgtcgctg 660 gtgctcagct tgccacagtt cttcatcttc catgtagcgc gtggcccatt cgtggaggag 720 ttttaccagt gcgtcaccca cggattctac acggcggatt ggcaggagca gatgtacgcc 780 accttcacgc tggtcttcac cttcctgctg ccgctgtgca tcctgtttgg cacctacatg 840 tccaccttcc gcaccatttc cagcagcgaa aagatgttcc agggatcaaa gttggccaac 900 tactcaacgg ccaaattgcc cacacagacg aatcgccaga ggctgataca caaggccaag 960 atgaagtcgc ttcgcatatc cgtggtgatc atcatagcgt ttctcatctg ctggacgccc 1020 tactacgtca tgatgattat gttcatgttc ctcaatccgg acaaaaggct gggcgacgat 1080 ctgcaggacg ccatcttctt cttcggcatg tcaaacagcc tggtcaaccc actcatctac 1140 ggtgccttcc acctgtgtcc tggcaaaggg ggcaagtcga gcggcggggg cggcaacaac 1200 aacgcctaca gcttgaacag gggcgactcg cagcgcactc catccatgct aacggcggtg 1260 acgcaggtgg acggcacagg tggcagttcc cgccagatgc gggccttccg ccagcagagc 1320 tactaccgca gctcctccaa cggcacagcc ggaccgggtg cagctccctt taaggagcag 1380 gttggcctgc tgcacgtggg tcccggcaat gggacgcccg gtggctccgt ctctagcggc 1440 gccacgccgc agttgatccg taagggatcg gctctgttgg cccgacaacc cagctgtctg 1500 agggagcagg agcaccagca gcgtttgctg ctgcacgaga agccctcgac cctggtgctc 1560 agctacgaca gccagcgggg cggagtgggc gtgggcgtgg ccagcggtct gctggacaac 1620 aacgagcgag tgtcgagcgt gtga 1644

<210> 198 <211> 547 <212> PRT <213> Drosophila

<400> 198

Met Glu Asp Glu Trp Gly Ser Phe Asp Arg Leu Pro Ser Val Pro Ser 1 5 10 15

258 Ala Ser Met Asp Leu Glu Thr Glu Asn Glu Val Val Ser Asn Trp Ser

20 25 30

Thr Leu Ala Asn Phe Thr Arg Leu Val Ala Gly Ala Ala Pro Glu He

35 40 45

Val Asn Tyr Thr Leu Asn Met He Asp Val Gly Val Gly Met Ala Thr

50 55 60

Asp He Ser Asn Leu Ser Val Pro Glu His Val Met Asp His Ala Pro 65 70 75 80

Gin Leu Ser Arg Ser Gly Leu Leu Lys Val Tyr Val Leu Ala Val Met

85 90 95

Ala Leu Phe Ser Leu Leu Gly Asn Leu Leu Thr He Trp Asn He Tyr

100 105 110

Lys Thr Arg He Ser Arg Arg Asn Ser Arg His Thr Trp Ser Ala He

115 120 125

Tyr Ser Leu Met Phe His Leu Ser He Ala Asp Val Leu Val Thr Trp

130 135 140

Phe Cys He He Gly Glu Ala Ala Trp Cys Tyr Thr Val Gin Trp Leu 145 150 155 160

Ala Asn Glu Leu Thr Cys Lys Leu Val Lys Leu Phe Gin Met Phe Ser

165 170 175

Leu Tyr Leu Ser Thr Tyr Val Leu Val Leu He Gly Val Asp Arg Trp

180 185 190

He Ala Val Lys Tyr Pro Met Lys Ser Leu Asn Met Ala Lys Arg Cys

195 200 205

His Arg Leu Leu Gly Gly Thr Tyr He Leu Ser Leu Val Leu Ser Leu

210 215 220

Pro Gin Phe Phe He Phe His Val Ala Arg Gly Pro Phe Val Glu Glu 225 230 235 240

Phe Tyr Gin Cys Val Thr His Gly Phe Tyr Thr Ala Asp Trp Gin Glu

245 250 255

Gin Met Tyr Ala Thr Phe Thr Leu Val Phe Thr Phe Leu Leu Pro Leu

260 265 270

Cys He Leu Phe Gly Thr Tyr Met Ser Thr Phe Arg Thr He Ser Ser

275 280 285

Ser Glu Lys Met Phe Gin Gly Ser Lys Leu Ala Asn Tyr Ser Thr Ala

290 295 300

Lys Leu Pro Thr Gin Thr Asn Arg Gin Arg Leu He His Lys Ala Lys 305 310 315 320

Met Lys Ser Leu Arg He Ser Val Val He He He Ala Phe Leu He

325 330 335

Cys Trp Thr Pro Tyr Tyr Val Met Met He Met Phe Met Phe Leu Asn

340 345 350

Pro Asp Lys Arg Leu Gly Asp Asp Leu Gin Asp Ala He Phe Phe Phe

355 360 365

Gly Met Ser Asn Ser Leu Val Asn Pro Leu He Tyr Gly Ala Phe His

370 375 380

Leu Cys Pro Gly Lys Gly Gly Lys Ser Ser Gly Gly Gly Gly Asn Asn 385 390 395 400

Asn Ala Tyr Ser Leu Asn Arg Gly Asp Ser Gin Arg Thr Pro Ser Met

405 410 415

Leu Thr Ala Val Thr Gin Val Asp Gly Thr Gly Gly Ser Ser Arg Gin

420 425 430

Met Arg Ala Phe Arg Gin Gin Ser Tyr Tyr Arg Ser Ser Ser Asn Gly

435 440 445

Thr Ala Gly Pro Gly Ala Ala Pro Phe Lys Glu Gin Val Gly Leu Leu

450 455 460

His Val Gly Pro Gly Asn Gly Thr Pro Gly Gly Ser Val Ser Ser Gly 465 470 475 480

Ala Thr Pro Gin Leu He Arg Lys Gly Ser Ala Leu Leu Ala Arg Gin 485 490 495

259 Pro Ser Cys Leu Arg Glu Gin Glu His Gin Gin Arg Leu Leu Leu His

500 505 510

Glu Lys Pro Ser Thr Leu Val Leu Ser Tyr Asp Ser Gin Arg Gly Gly

515 520 525

Val Gly Val Gly Val Ala Ser Gly Leu Leu Asp Asn Asn Glu Arg Val

530 535 540

Ser Ser Val 545

260