WO2001070334A1

WO2001070334A1 - Equipment designed to stimulate and optimise the biomolecular and cellular reorganization

Info

Publication number: WO2001070334A1
Application number: PCT/CH2000/000603
Authority: WO
Inventors: Saverio Giangregorio
Original assignee: ACTIVE MEDICAL DEVICES SA
Current assignee: ACTIVE MEDICAL DEVICES SA
Priority date: 2000-03-24
Filing date: 2000-11-13
Publication date: 2001-09-27
Anticipated expiration: 2002-09-24
Also published as: AU1125001A

Abstract

The appliance in question is designed to stimulate and optimise the biomolecular and cellular reorganization of any kind of organic tissue, in such a way as to rebalance the natural defences that exist in an individual or in any kind of cellular system. The appliance contains components which are able to generate fields of appropriate radio frequencies, with continuous programmed modulation in sequential order, to create treatment energies in accordance with a determined code. These resonate with the natural sub-atomic, atomic, molecular and cellular oscillators of the individual or any kind of cellular system, to rebalance the metabolic and ion interchange functions. In this way, the various elements find themselves in a situation of equilibrium, due to the correct symbiosis that exists between the stimulator element and the organism.

Description

EQUIPMENT DESIGNED TO STIMULATE AND OPTIMISE THE BIOMOLECULAR AND CELLULAR

REORGANI ZATION

Equipment designed to stimulate and optimise the biomolecular and cellular reorganisation of any kind of organic tissue.

This invention is a piece of equipment designed to stimulate the natural defences of any individual or cellular system. It is used to generate radio frequency fields at overlapping levels in a sequential order, with programmed modulations, with a view to recreating the various biochemical elements that exist in a living organism.

The appliance is also used to normalise all the cellular properties, including reproduction, respiration, assimilation, growth excitability and mobility.

The type of energy produced by the appliance forms a group of communication codes with the molecular and cellular systems. This technique of combinations forms an optimum bioelectricai synergism (cell + electrical oscillator) which backs up the cellular functions to bring about a general improvement in all the physiological activities.

Reason for the application

The applicant is unaware of any other patents with the same features, and while there are similar applications they do not operate at the same level. The name itself, Regeneration Therapy, is based exclusively on studies carried out by the applicant.

We will set out and analyse all the areas of application and inherent technical and application reports on the system below.

Introduction

Scientific principle of the PhysioMed

The PhysioMed was created to generate modulations of radio frequencies at overlapping levels and in sequential order, with programmed modulations geared towards creating special treatment energies that stimulate the natural defences existing in a living being to the maximum.

These fields, with the features referred to above, represent linguistic codes for communication with the organised sub-atomic, atomic, molecular and cellular systems, which in the final analysis have to be considered as a group of natural oscillators that obey the same laws as electrical oscillators applied to partial and total blocks, but within the same space and at the same time.

This technique of combinations creates an optimum bioelectrical synergism to back up the cellular functions, in this way obtaining a general improvement and normalisation of all the physiological activities.

Technical and scientific report

Living matter has various levels of organisation and variable dimensions. The first and most simple level of matter is the atom, which forms the basis of all the other levels of organisation. At the level immediately above this, we can see that the atoms of the various elements present in nature tend to aggregate spontaneously in molecules, most of which are simple and made up of a small quantity of associated elements. It is only in living beings that we can see the formation of molecules that are often large and complex, with carbon chains of various lengths as their central point. The carbon molecules of living organisms interact with each other in an ordered manner, to create new and higher levels of organisation. On the basis of this first series of scientifically known concepts, we can go on to state that the appliance in question will make it possible for determined phenomena of biostructural reorganisation in all organic tissues to take place. The principle of communication among the cells develops through the acquisition of all the signals that reach the cell from the outside. These are captured by the "molecular antennae" (the receptors or receptor cells). But, in the same way as with electromagnetic television waves, a transport and conversion system for the signal is necessary if an organisational response is to be obtained (the picture). In this way, the cells have developed a system to convert the signals arriving from the outside. The transport, conversion and amplification of the signal received enable the tissue cell or cells to respond in a suitable way, in accordance with requirements.

We are already aware that there may be signals that are able to penetrate the cell (steroid hormones) where the receptors are located. In this case the acquisition of the cell takes place directly.

In the case of information that is unable to overcome the barrier of the cellular membrane (water soluble hormones), more complex mechanisms are necessary. The internal signals are transported by a series of small molecules known as "second messengers". In molecular terms, the transmission process for this signal depends on a series of proteins contained in the cellular membrane. Each of these transmits an item of information which induces an alteration in the shape, and consequently in the function, of the adjacent protein. At a certain point, the information reaches small molecules or even the organic ions present in the cytoplasm. These are the second messengers, whose distribution ensures that the signal spreads and amplifies rapidly throughout the cell.

The number of second messengers is limited. This means that the routes inside the cell for the transmission of the signals are universal, and also able to regulate an enormous variety of physiological and biochemical processes. Two main routes for the re-transmission of the signals are known. One of these uses a nucleotide as second messenger, while the other uses a combination of second messengers, including calcium ions (Ca2+) and other substances deriving from the components of the cellular membrane (phospholipids). The two routes have many things in common. In both of them, the initial composition, that is, the receptor molecule present on the cell surface, transmits the information through the plasma membrane and inside the cell itself, by means of a family of proteins that operate as transducers, known as G proteins. In both routes, the G proteins activate an amplifier enzyme which is always found in the cellular membrane. This transforms the precursor molecules into second messengers which spread the signals in the cell. The final stages in the process are also similar. The second messengers induce a number of cellular proteins to modify their structure, producing as a result the activation or inhibition of the function of a determined protein. The second messengers therefore turn on or off the switches that regulate the protein activity, creating different conditions inside the cell. These conditions will determine the type of response that the cell will give to the signal received from the outside. In most cases, the second messenger is linked to a component part of an enzymatic protein, inducing the activif- of the component that brings about the enzyme functions. In some cases, there are receptors that cross the membrane and present part of the protein inside the cell that performs enzymatic activities similar to those described above. In this case, the signal transport and amplification mechanisms are not necessary, while the switch is turned on and off by the signal bond itself. As an alternative to these signal transmission methods, the action of the receptors which have bound the messenger may consist in the selective opening of small pores or specific channels for certain ions (such as calcium) present on the surface of the cellular membrane.

In the case of calcium (Ca2+), the entrance of the cell has the same effect as the presence of the second messengers. Most of the information conveyed by these chains of messengers ends up going to the nucleus of the cell, where it regulates or induces the expression of the genes.

The messages carried by the soluble molecules in the fats (steroid hormones) which are able to cross the membrane also arrive at the nucleus. The receptors for these hormones, as we saw above, are found in the cytoplasm. They are proteins whose shape is modified by the bond with the molecule of the signal. The modified protein enters the nucleus and becomes able to form a bond with the DNA, the large molecule that conserves the genetic information at precise points where it is used to regulate the activation of the genes present in the point where the bond has been created.

This effect is known as the primary response. In other cases, there is a secondary response, that is, the products of the primary response may have as their function the activation of the other genes, by forming a bond with the DNA, by amplifying and varying the response.

The response to the steroid hormones, which is similar to that for all the hormones, depends on the nature of the hormone and that of the target cell. It would appear, in fact, that the same receptors for a determined hormone present in different types of cell give different responses, because they link different points of the DNA in a specific manner. Naturally, to ensure that there is no biological unbalance in the cell and organism that would overflow into physiological conditions, the entire system of signals has to be finely regulated.

One method of regulation is that of the indirect signalling system, in which the negative retroaction mechanisms, which are fields of continuous, controlled frequencies, dampen the primary signals. Another way to regulate the response is to act on the receptors. After the water soluble hormones link up with their receptors on the surface of the target cells, the cells often swallow these up by endocytosis and destroy them, In this iy, as there are no longer any receptors or their number has been reduced, the capacity to respond to the hormone also ceases. In other cases, the receptor is "internalised" by endocytosis and kept in vesicles, for later remounting on the cellular membrane.

At times the receptor remains on the surface of the cell, but modifies its formation in such a way that it is no longer able to bind the hormone, or else it does bind it but without transmitting the signal into the cell.

All these phenomena last for a certain number of hours, whereupon the cell returns to normal conditions and can once again receive signals. Yet another way of regulating the response is to destroy the second messengers and reduce the amplification of the signal. This takes place by means of specific enzymes within the space of a few minutes.

The same may also occur for the primary signals (hormones of a protein nature), which are eliminated by lithic enzymes.

On the basis of the above explanation, we can clearly see how complex and sophisticated the network of signals exchanged among the signals has to be if the organism is to remain in perfect biological balance.

If only one of these systems should go out of control, for some reason linked to the regulation, the effects produced are much greater than the initial alteration. The situation is similar to that of a television that, due to a breakdown, can no longer be switched off or adjusted. Something similar could take place in the cell which, due to a second messenger, can no longer be regulated.

Circuit description

Introduction

The purpose of the appliance is to generate a series of radio frequency signals modulated and controlled in breadth, for therapeutic and preventive purposes.

Six independent channels are provided for this purpose, each of which can be set as required in terms of its operating parameters.

The R.F. signal generation starts and stops in an equally independent way.

To obtain the performance levels typical of the appliance, three controllers, each made up of two channels, are provided, consisting of five electronic cards ^used on a main mother board. The mother board also houses the power supplier that provides the power necessary for the operation of the circuits. Functional blocks

The appliance can be divided into four functional blocks:

Mother board

The mother board houses:

the power supplier, which generates the power necessary for the operation of the unit

the channel card connectors

the R.F. output connectors

the connections among the various services inside the appliance

Channels 1 and 2

A group of two channels is made up of the following five cards:

The key and display support card, located behind the front panel

The interface card between the microcontroller and the keys, warning lamps and

display

The control card

The R.F. generation card for channel 1

The R.F. generation card for channel 2

Channels 3 and 4

As for channels 1 and 2

Channels 5 and 6

As for channels 1 and 2

The cards that make up the group of two channels are identical and interchangeable with those of the other groups of two channels. The difference is due only to the physical location of the cards on the mother board. Power supplier

The power supplier generates three stabilised voltages, +5V, +12V and +24V. The alternating voltage from the filtered socket located in the rear panel is connected to three transformers, one for each voltage to be generated.

The diode bridge that rectifies the voltage and the two filter condensers are connected on the secondary. The direct voltage obtained in this way is stabilised by means of an LM78xx linear regulator and an output condenser.

Support card for warning lamps, keys and display (for two channels)

The following are located on the card:

10 warning lamps with power supply resistance

16 keys with the resistant pull-up networks, of the SIL type

6 x 7-segment displays with a height of 8 mm

The card is connected to the interface by a flexible, flat 50-pole cable, with connectors at the ends.

Interface card: keys, warning lamps, display

This card contains:

2 x 74HC573 integrated circuits to drive the warning lamps

2 x 74HC541 integrated circuits for the input from the keys

1 x ICL7218 integrated circuit to drive the displays

All five ports are located on the data bus of the microcontroller and the integrated display driver is also located on the address bus. The port strophes are of the memory mapped type, where the microcontroller sees the ports as memory addresses which reach the card already decoded.

Microcontroller card

The following are located on the card:

1 Hitachi H8/3334 integrated circuit which acts as microcontroller 1 x 74HC14 integrated circuit for the microcontroller reset

1 x GAL 22V10 integrated circuit to decode the address bus

1 x ICL 232 integrated circuit to make up the serial interface

The microcontroller is used to manage the operating parameter settings and receive the parametric data. It also controls the start and stop and the generation of each type of timing necessary for the various emission characteristics.

Two direct microcontroller outputs (not memory mapped) control the modulation of the R.F. generators. The microcontroller also counts the emission time, with the display of the time remaining and the issue of an acoustic warning signal a minute before the end of the application.

The following are located on the card:

1 x 74HC14 integrated circuit, used as interface between the microcontroller and the modulator of the R.F. circuit

1 x CD4001 integrated circuit, used as R.F. detector

2 transistors for the R.F. modulator

1 transistor for the generation of the R.F.

Transistor T3 operates as an oscillator / R.F. generator, and is controlled by the two transistors Tl and T2, which modulate the emission in on/off mode, to obtain the impulse trains required.

The oscillation frequency (carrier) is determined by the constants LI, L2 and C9.The detector circuit for the R.F. produced is obtained from the diodes Dl, D2 and D3 and the condenser C6, which operate as envelope detectors. In addition, the presence of R.F. activates the CD4001, which causes the R.F. emission signalling lamps to flash. CONTENTS

PAGE 1 - PRESENTATION OF THE INVENTION

PAGE 1 - REASON FOR THE APPLICATION

PAGE 2 - INTRODUCTION

PAGE 2 - TECHNICAL AND SCIENTIFIC REPORT

PAGE 5 - CIRCUIT DESCRIPTION

PAGE 9 - CLAIMS

PAGE 11 - SUMMARY

PAGE 12 - CONTENTS

Appendices:

PAGE 13 - Diagram 1 - Terminal for therapy - 600 x 200 mm

PAGE 14 - Diagram 2 - Terminal type A for therapy - 310 x 120 mm

PAGE 15 - Diagram 3 - Terminal type B for therapy - 287 x 90 mm

PAGE 16 - Diagram 4 - Terminal type C for therapy - 285 x 80 mm

PAGE 17 - Diagram 5 - Block diagram of the equipment

PAGE 18 - Diagram HT 811 - Keys - Warning lamps - Display

PAGE 19 - Diagram HT 811 - Keys - Warning lamps - Display

PAGE 20 - Diagram HT 812 - I/O interface

PAGE 21 - Diagram HT 813 - Microcontroller - bus

PAGE 22 - Diagram HT 813 - Microcontroller - reset

PAGE 23 - Diagram HT 814 - R.F. generator

PAGE 24 - Diagram HT 817 - Mother board - power supplie

Claims

1. Appliance designed to stimulate and normalise the natural defences in an individual or in any cellular system, made up of components that generate fields of specific radio frequencies, at overlapping levels and in sequential order, with programmed modulation, to create treatment energies in line with determined codes that resonate with the natural sub-atomic, atomic, molecular and cellular oscillators of the individual or any type of cellular system to rebalance the metabolism.

2. An appliance as described in claim 1 with a multiple generation system at controlled breadth, made up of a microcontroller for the handling of the operating parameters for the entire system, two transistors (T01 and T02) that act as sequential modulators from which the impulse trains required are obtained, a single transistor (T03) that represents the oscillating and R.F. generating part, the integrated circuit (IC02) that operates as the R.F. signal detector, the integrated circuit (ICO 1) used as interface between the microprocessor and the modulating part of the R.F. circuit, an integrated circuit (IC03) that operates as the decoder of the logical and analogue address bus, and a further integrated circuit (IC04) which is used to create the serial interface of the microprocessor with the data received.

3. An appliance as described in claim 2, with an integrated circuit (IC02) located at the microprocessor input (IC01), pin 8, used to reset the microprocessor, and a quartz (XT01), which determines the microprocessor operating clock, connected to pins 9 and 10 of the integrated circuit (IC01).

4. An accessory to the appliance as described in claim 3, essential for the therapy, defined as a terminal or antenna, with the following features: internal dimensions: (pure circuit part) 155 x 545 mm. The distances among the six series of tracks that make up the circuit are 12 mm each. There are 13 parallel tracks, and the distance between one track and another is 0.5 mm, the same as the thickness. The structure consists of two sheets of polyester, with dimensions 600 x 200 mm, inside which a high concentration silver-treated ink circuit develops over the dimensions described in this claim.

5. An accessory to the appliance as described in claim 4, consisting of the connection system between the therapy terminal and the appliance itself, in the form of a coaxial cable terminating in a R.F. connector and, at the other end, two automatic buttons in a die cast non-conducting material, separated by a fork in a diecast material that forms a double deflection.

6. An accessory to the appliance as described in claim 5, consisting of a therapeutic terminal (A) known as a dental mask, with the following features: dimensions of the most distant points 310 x 120 mm, with wraparound shape for the face and an opening for the mouth. The structure consists of two sheets of profiled polyester with a circuit inside that emits the appropriate radio frequencies, traced in ink with a high percentage of silver (70%), with 70 tracks each 3 mm wide, arranged at a distance of 3 mm from each other. The ends of the tracks terminate in two automatic buttons for the connection with the appliance.

7. An accessory to the appliance as described in claim 6, consisting of a therapeutic terminal (B) known as a dental mask, with the following features: dimensions of the most distant points 287 x 90 mm, with wraparound shape for the face and an opening for the mouth. The structure consists of two sheets of profiled polyester with a circuit inside that emits the appropriate radio frequencies, traced in ink with a high percentage of silver (70%), with 56 tracks each 3.5 mm wide, arranged at a distance of 2.5 mm from each other. The ends of the tracks terminate in two automatic buttons for the connection with the appliance.

8. An accessory to the appliance as described in claim 7, consisting of a therapeutic terminal (C) known as a dental mask, with the following features: dimensions of the most distant points 285. x 80 mm, with wraparound shape for the face and an opening for the mouth. The structure consists of two sheets of profiled polyester with a circuit inside that emits the appropriate radio frequencies, traced in ink with a high percentage of silver (70%), with 40 tracks each 4 mm wide, arranged at a distance of 4 mm from each other. The ends of the tracks terminate in two automatic buttons for the connection with the appliance.