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WO2001070381A3 - Procede et dispositif de regulation acoustique de solutions liquides dans des dispositifs microfluidiques - Google Patents

Procede et dispositif de regulation acoustique de solutions liquides dans des dispositifs microfluidiques Download PDF

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Publication number
WO2001070381A3
WO2001070381A3 PCT/US2001/009163 US0109163W WO0170381A3 WO 2001070381 A3 WO2001070381 A3 WO 2001070381A3 US 0109163 W US0109163 W US 0109163W WO 0170381 A3 WO0170381 A3 WO 0170381A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
microfluidic devices
liquid solutions
controlling liquid
acoustic energy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/009163
Other languages
English (en)
Other versions
WO2001070381A2 (fr
Inventor
James A Laugharn Jr
Brevard S Garrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covaris LLC
Original Assignee
Covaris LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covaris LLC filed Critical Covaris LLC
Priority to CA002402985A priority Critical patent/CA2402985A1/fr
Priority to AU2001250929A priority patent/AU2001250929A1/en
Publication of WO2001070381A2 publication Critical patent/WO2001070381A2/fr
Publication of WO2001070381A3 publication Critical patent/WO2001070381A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2202—Controlling the mixing process by feed-back, i.e. a measured parameter of the mixture is measured, compared with the set-value and the feed values are corrected
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0427—Numerical distance values, e.g. separation, position
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/045—Numerical flow-rate values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0477—Numerical time values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00484—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels
    • B01J2219/00486—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels by sonication or ultrasonication
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Selon l'invention, on utilise l'énergie acoustique pour réguler le mouvement d'un fluide. Dans un mode de réalisation, on dirige l'énergie acoustique au niveau d'éléments choisis favorisant une nucléation naturelle, de manière à réguler le mouvement d'un fluide. Dans un autre mode de réalisation, on apporte une énergie acoustique concentrée ou non au niveau d'éléments choisis favorisant une nucléation placée, de manière à réguler le mouvement du fluide. Dans une variante de réalisation, l'invention comprend une source acoustique, un module de commande destiné à commander le fonctionnement de la source acoustique, ainsi qu'un ou plusieurs éléments favorisant la nucléation et situés à proximité du fluide à réguler, ou dans ce fluide.
PCT/US2001/009163 2000-03-21 2001-03-21 Procede et dispositif de regulation acoustique de solutions liquides dans des dispositifs microfluidiques Ceased WO2001070381A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002402985A CA2402985A1 (fr) 2000-03-21 2001-03-21 Procede et dispositif de regulation acoustique de solutions liquides dans des dispositifs microfluidiques
AU2001250929A AU2001250929A1 (en) 2000-03-21 2001-03-21 Method and apparatus for acoustically controlling liquid solutions in microfluidic devices

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19129700P 2000-03-21 2000-03-21
US60/191,297 2000-03-21
US19892300P 2000-04-21 2000-04-21
US60/198,923 2000-04-21
US24383800P 2000-11-08 2000-11-08
US60/243,838 2000-11-08

Publications (2)

Publication Number Publication Date
WO2001070381A2 WO2001070381A2 (fr) 2001-09-27
WO2001070381A3 true WO2001070381A3 (fr) 2002-04-18

Family

ID=27392883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/009163 Ceased WO2001070381A2 (fr) 2000-03-21 2001-03-21 Procede et dispositif de regulation acoustique de solutions liquides dans des dispositifs microfluidiques

Country Status (3)

Country Link
AU (1) AU2001250929A1 (fr)
CA (1) CA2402985A1 (fr)
WO (1) WO2001070381A2 (fr)

Cited By (1)

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US7223363B2 (en) 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays

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US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
SE0200860D0 (sv) 2002-03-20 2002-03-20 Monica Almqvist Microfluidic cell and method for sample handling
US6814852B2 (en) 2002-07-15 2004-11-09 Hewlett-Packard Development Company, L.P. Generation of gas in a lab-on-a-chip environment
US8030092B2 (en) 2003-11-07 2011-10-04 Princeton Biochemicals, Inc. Controlled electrophoresis method
JP2007510935A (ja) 2003-11-07 2007-04-26 プリンストン・バイオケミカルズ・インコーポレーテッド 多次元電気泳動装置
NL1026321C2 (nl) * 2004-06-03 2005-12-06 Univ Twente Inrichting en werkwijze voor het teweegbrengen van directioneel transport.
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
EP2041573B1 (fr) 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Procédés et dispositifs destinés à des dosages immunologiques microfluidiques pratiqués au point de service
KR101851117B1 (ko) 2010-01-29 2018-04-23 마이크로닉스 인코포레이티드. 샘플-투-앤서 마이크로유체 카트리지
CN104136123B (zh) 2012-01-09 2017-03-01 精密公司 微流体反应器系统
CN104919035B (zh) 2012-12-21 2017-08-11 精密公司 便携式荧光检测系统和微测定盒
US10065186B2 (en) 2012-12-21 2018-09-04 Micronics, Inc. Fluidic circuits and related manufacturing methods
JP6935167B2 (ja) 2012-12-21 2021-09-15 ペルキネルマー ヘルス サイエンシーズ， インコーポレイテッド マイクロ流体使用のための低弾性フィルム
EP2953710B1 (fr) * 2013-02-11 2023-06-07 Andrew E. Bloch Appareil et procédé de fourniture d'oscillations asymétriques
EP2994532B1 (fr) 2013-05-07 2017-11-15 Micronics, Inc. Procédés de préparation d'échantillons d'acides nucléiques faisant appel à des minéraux argileux et à des solutions alcalines
AU2014262726B2 (en) 2013-05-07 2019-09-19 Revvity Health Sciences, Inc. Device for preparation and analysis of nucleic acids
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
GB201420061D0 (en) 2014-11-11 2014-12-24 Univ Glasgow Nebulisation of liquids
WO2016144931A1 (fr) 2015-03-09 2016-09-15 The Research Foundation For The State University Of New York Systèmes et procédés destinés à favoriser des activités cellulaires assurant l'entretien, la réparation et la régénération des tissus
KR20240117163A (ko) * 2016-12-02 2024-07-31 에토너스 인코포레이티드 유체 처리 시스템 및 이를 사용한 방법
CN109821466B (zh) * 2019-01-09 2021-07-06 武汉智能装备工业技术研究院有限公司 一种多通道液体配料全自动调度系统及方法
RU2767096C2 (ru) * 2020-07-15 2022-03-16 Общество с ограниченной ответственностью "НаноТехЦентр" Способ обработки неоднородных гидросред (жидкостей)
CN112632746B (zh) * 2020-11-23 2022-04-26 浙江大学 一种优化的土壤统计物理导热系数模型构建方法
WO2023039131A2 (fr) * 2021-09-10 2023-03-16 Elephas Biosciences Corporation Système et procédé de coupe de tissu

Citations (10)

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GB1015962A (en) * 1961-10-31 1966-01-05 Sirius Improvements in or relating to methods of and devices for treating substances with sound and ultrasonic waves
US3614069A (en) * 1969-09-22 1971-10-19 Fibra Sonics Multiple frequency ultrasonic method and apparatus for improved cavitation, emulsification and mixing
DE2557668A1 (de) * 1975-12-20 1977-06-30 Innotec Oy Vorrichtung zur behandlung von proben, insbesondere fluessigkeitsproben mit ultraschall
US4571087A (en) * 1983-03-22 1986-02-18 Board Of Regents, University Of Texas System Array sonicator apparatus for automated sample preparation
US5026167A (en) * 1989-10-19 1991-06-25 Heat Systems Incorporated Ultrasonic fluid processing system
EP0643982A1 (fr) * 1993-06-25 1995-03-22 DORNIER MEDICAL SYSTEMS, Inc. Sonde pour ultrasonothermothérapie
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
WO1998058417A1 (fr) * 1997-06-16 1998-12-23 Puskas William L Systemes de traitement ultrasonore d'articles delicats
DE19756874A1 (de) * 1997-12-19 1999-06-24 Basf Ag Vorrichtung zum Herstellen von dispersen Stoffgemischen mittels Ultraschall und Verwendung einer derartigen Vorrichtung
WO2000025125A1 (fr) * 1998-10-28 2000-05-04 Covaris, Inc. Appareil et procedes destines au traitement par controle de l'energie sonique

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1015962A (en) * 1961-10-31 1966-01-05 Sirius Improvements in or relating to methods of and devices for treating substances with sound and ultrasonic waves
US3614069A (en) * 1969-09-22 1971-10-19 Fibra Sonics Multiple frequency ultrasonic method and apparatus for improved cavitation, emulsification and mixing
DE2557668A1 (de) * 1975-12-20 1977-06-30 Innotec Oy Vorrichtung zur behandlung von proben, insbesondere fluessigkeitsproben mit ultraschall
US4571087A (en) * 1983-03-22 1986-02-18 Board Of Regents, University Of Texas System Array sonicator apparatus for automated sample preparation
US5026167A (en) * 1989-10-19 1991-06-25 Heat Systems Incorporated Ultrasonic fluid processing system
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
EP0643982A1 (fr) * 1993-06-25 1995-03-22 DORNIER MEDICAL SYSTEMS, Inc. Sonde pour ultrasonothermothérapie
WO1998058417A1 (fr) * 1997-06-16 1998-12-23 Puskas William L Systemes de traitement ultrasonore d'articles delicats
DE19756874A1 (de) * 1997-12-19 1999-06-24 Basf Ag Vorrichtung zum Herstellen von dispersen Stoffgemischen mittels Ultraschall und Verwendung einer derartigen Vorrichtung
WO2000025125A1 (fr) * 1998-10-28 2000-05-04 Covaris, Inc. Appareil et procedes destines au traitement par controle de l'energie sonique

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223363B2 (en) 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US7235400B2 (en) 2001-03-09 2007-06-26 Biomicro Systems, Inc. Laminated microarray interface device

Also Published As

Publication number Publication date
WO2001070381A2 (fr) 2001-09-27
CA2402985A1 (fr) 2001-09-27
AU2001250929A1 (en) 2001-10-03

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