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WO2001068842A3 - Regulation of human p2y-like gpcr protein - Google Patents

Regulation of human p2y-like gpcr protein Download PDF

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Publication number
WO2001068842A3
WO2001068842A3 PCT/EP2001/002785 EP0102785W WO0168842A3 WO 2001068842 A3 WO2001068842 A3 WO 2001068842A3 EP 0102785 W EP0102785 W EP 0102785W WO 0168842 A3 WO0168842 A3 WO 0168842A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
asthma
reagents
diseases
gpcr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/002785
Other languages
French (fr)
Other versions
WO2001068842A2 (en
Inventor
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001244205A priority Critical patent/AU2001244205A1/en
Publication of WO2001068842A2 publication Critical patent/WO2001068842A2/en
Publication of WO2001068842A3 publication Critical patent/WO2001068842A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents which regulate human P2Y-like GPCR protein and reagents which bind to human P2Y-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, Parkinson's diseases, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
PCT/EP2001/002785 2000-03-14 2001-03-13 Regulation of human p2y-like gpcr protein Ceased WO2001068842A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001244205A AU2001244205A1 (en) 2000-03-14 2001-03-13 Regulation of human p2y-like gpcr protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18904500P 2000-03-14 2000-03-14
US60/189,045 2000-03-14

Publications (2)

Publication Number Publication Date
WO2001068842A2 WO2001068842A2 (en) 2001-09-20
WO2001068842A3 true WO2001068842A3 (en) 2002-01-24

Family

ID=22695675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/002785 Ceased WO2001068842A2 (en) 2000-03-14 2001-03-13 Regulation of human p2y-like gpcr protein

Country Status (2)

Country Link
AU (1) AU2001244205A1 (en)
WO (1) WO2001068842A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7531310B2 (en) 2000-11-17 2009-05-12 Bristol-Myers Squibb Company Methods of diagnosing Crohn's disease by measuring expression level of RNA encoding human G-protein coupled receptor, HGPRBMY11
WO2005040829A2 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 17 (gpr17)
WO2005103291A1 (en) 2004-04-27 2005-11-03 Takeda Pharmaceutical Company Limited Novel ligand of g-protein-conjugated receptor protein and use thereof
ITMI20042007A1 (en) * 2004-10-21 2005-01-21 Consiglio Nazionale Ricerche "GPR17 RECIPE MODULATORS AND THEIR THERAPEUTIC USES"

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020045A2 (en) * 1995-11-15 1997-06-05 Cor Therapeutics, Inc. P2u2 PURINERGIC RECEPTOR
EP0866126A1 (en) * 1997-03-19 1998-09-23 Smithkline Beecham Corporation CDNA clone HNFDY20 that encodes a novel human 7-transmembrane receptor
EP0878542A2 (en) * 1997-04-22 1998-11-18 Smithkline Beecham Corporation cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor
WO1999002675A1 (en) * 1997-07-09 1999-01-21 Euroscreen S.A. G-coupled receptor showing selective affinity for atp
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020045A2 (en) * 1995-11-15 1997-06-05 Cor Therapeutics, Inc. P2u2 PURINERGIC RECEPTOR
EP0866126A1 (en) * 1997-03-19 1998-09-23 Smithkline Beecham Corporation CDNA clone HNFDY20 that encodes a novel human 7-transmembrane receptor
EP0878542A2 (en) * 1997-04-22 1998-11-18 Smithkline Beecham Corporation cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor
WO1999002675A1 (en) * 1997-07-09 1999-01-21 Euroscreen S.A. G-coupled receptor showing selective affinity for atp
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BOEYNAEMS J-M J-M ET AL: "P2Y receptors: in the middle of the road", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 1, January 2000 (2000-01-01), pages 1 - 3, XP004189127, ISSN: 0165-6147 *
COMMUNI D ET AL: "Receptors responsive to extracellular pyrimidine nucleotides", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 18, no. 3, 1 March 1997 (1997-03-01), pages 83 - 86, XP004058395, ISSN: 0165-6147 *
DATABASE EMBL SEQUENCE DATABASE 22 January 2000 (2000-01-22), DUNN, M.: "Human DNA sequence from clone RP11-108P5 on chromosome 13q14.12-21.1", XP002174876 *
HEISE CHRISTOPHER E ET AL: "Characterization of the human cysteinyl leukotriene 2 receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 39, 29 September 2000 (2000-09-29), pages 30531 - 30536, XP002171473, ISSN: 0021-9258 *
JANSSENS R ET AL: "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 236, 9 July 1997 (1997-07-09), pages 106 - 112, XP002124833, ISSN: 0006-291X *
LEON C ET AL: "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 171, no. 2, 1 June 1996 (1996-06-01), pages 295 - 297, XP004042812, ISSN: 0378-1119 *
STADEL J M ET AL: "Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 18, no. 11, 1 November 1997 (1997-11-01), pages 430 - 437, XP004099345, ISSN: 0165-6147 *
TAKASAKI JUN ET AL: "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 274, no. 2, 2 August 2000 (2000-08-02), pages 316 - 322, XP002933371, ISSN: 0006-291X *

Also Published As

Publication number Publication date
AU2001244205A1 (en) 2001-09-24
WO2001068842A2 (en) 2001-09-20

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